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https://www.readbyqxmd.com/read/29475208/resistance-training-threshold-for-elevating-bone-mineral-density-in-growing-female-rats
#1
Azriel D Dror, Katie Virk, Kassandra Lee, Aaron Gerston, Anuradha Prakash, Marcia J Abbott, S Victoria Jaque, Ken D Sumida
The purpose of this study was to determine the minimum amount of resistance exercise that would stimulate bone formation yielding an elevation in bone mineral density (BMD) during the growth period in female rats. Female rats were randomly divided into: Control (Con, n=8), 3 ladder climb resistance-trained group (3LC, n=8), 4 ladder climb resistance-trained group (4LC, n=8), 5 ladder climb resistance-trained group (5LC, n=8), and 6 ladder climb resistance-trained group (6LC, n=8). All exercised groups were conditioned to climb a vertical ladder with weights appended to their tail 3 days/wk for a total of 6 wks...
February 23, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29475206/association-between-forefoot-bone-length-and-performance-in-male-endurance-runners
#2
Hiromasa Ueno, Tadashi Suga, Kenji Takao, Takahiro Tanaka, Jun Misaki, Yuto Miyake, Akinori Nagano, Tadao Isaka
Recently, we reported that the forefoot bones were longer in sprinters than in non-sprinters, and that longer forefoot bones correlated with higher sprint performance in sprinters. To further understand the superiority of long forefoot bones in athletic performance, we examined whether forefoot bone length was associated with running performance in endurance runners. The length of the forefoot bones of the big and second toes were measured using magnetic resonance imaging in 45 male well-trained endurance runners and 45 male untrained subjects...
February 23, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29475170/a-case-report-of-anterior-cruciate-ligament-and-posterolateral-corner-reconstruction-using-tendon-graft-preserved-in-situ
#3
Bosco Mpatswenumugabo, Emmanuel Bukara, Muhammed Semakula, Albert Nzayisenga, Rene Mukezamfura, Lambert Dusingizimana, Basile Habumugisha, Salvador Kamarampaka, Leon Mutesa, Alex Butera
INTRODUCTION: Combined anterior cruciate ligament (ACL) and posterolateral corner (PLC) reconstruction are a rare clinical entity in orthopedic literature, whose management requires different types of tendon grafts. Missed PLC injury leads to the failure of ACL repair due to the joint instability. PRESENTATION OF CASE: We are presenting a case of posttraumatic right ACL, PLC and lateral meniscus injury. The patient was taken to theatre for arthroscopic meniscectomy, ACL and PLC reconstruction...
February 17, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29475151/ct-angiography-of-the-aorta-in-patients-with-marfan-disease-high-pitch-mdct-at-different-levels-of-tube-voltage-combined-with-sinogram-affirmed-iterative-reconstruction
#4
P Freyhardt, N Solowjowa, G Böning, J Kahn, B Aufmesser, P Haage, F Streitparth
OBJECTIVES: Aim of the study was the comparison of high-pitch dual-source CTA of the aorta acquired with different tube currents and methods of image reconstruction in patients with Marfan Disease (MFS). BACKGROUND: Patients with MFS receive repeatedly CT examinations of the entire aorta what leads to high cumulative lifetime radiation doses. Routine clinical use of low-kV-protocols in combination with iterative reconstruction for imaging of the aorta is still limited although this approach may be of great benefit for patients in need of serial follow-up scans...
February 15, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29475111/pth-1-34-and-growth-hormone-in-prevention-of-disuse-osteopenia-and-sarcopenia-in-rats
#5
Mikkel Bo Brent, Annemarie Brüel, Jesper Skovhus Thomsen
Osteopenia and sarcopenia develops rapidly during disuse. The study investigated whether intermittent parathyroid hormone (1-34) (PTH) and growth hormone (GH) administered alone or in combination could prevent or mitigate disuse osteopenia and sarcopenia in rats. Disuse was achieved by injecting 4 IU botulinum toxin A (BTX) into the right hindlimb musculature of 12-14-week-old female Wistar rats. Seventy-two rats were divided into six groups: 1. Baseline; 2. Ctrl; 3. BTX; 4. BTX + GH; 5. BTX + PTH; 6...
February 20, 2018: Bone
https://www.readbyqxmd.com/read/29475110/pathological-fracture-risk-assessment-in-patients-with-femoral-metastases-using-ct-based-finite-element-methods-a-retrospective-clinical-study
#6
Amir Sternheim, Ornit Giladi, Yair Gortzak, MIchael Drexler, Moshe Salai, Nir Trabelsi, Charles Milgrom, Zohar Yosibash
Physician recommendation for prophylactic surgical fixation of a femur with metastatic bone disease (MBD) is usually based on Mirels' criteria and clinical experience, both of which suffer from poor specificity. This may result in a significant number of these health compromised patients undergoing unnecessary surgery. CT-based finite element analyses (CTFEA) have been shown to accurately predict strength in femurs with metastatic tumors in an ex-vivo study. In order to assess the utility of CTFEA as a clinical tool to determine the need for fixation of patients with MBD of the femur, an ad hoc CTFEA was performed on a retrospective cohort of fifty patients...
February 20, 2018: Bone
https://www.readbyqxmd.com/read/29475092/the-impact-of-donor-characteristics-on-the-invariant-natural-killer-t-cells-of-granulocyte-colony-stimulating-factor-mobilized-marrow-grafts-and-peripheral-blood-grafts
#7
Hong Yan, Zhao Xiangyu, Yu Xingxing, Bian Zhilei, Chang Yingjun, Yu Wang, Zhang Xiaohui, Xu Lanping, Huang Xiaojun, Zhao Xiaosu
INTRODUCTION: Invariant natural killer T cells (iNKTs) are a rare but vital subset of immunomodulatory T cells and play an important role in allogeneic hematopoietic stem cell trans-plantation (HSCT). The association of donor characteristics with the number and frequency of the iNKTs subsets in allografts remains poorly understood. In this paper, we prospectively investigate the association of donor characteristics with iNKTs dose and frequency in granulocyte-colony-stimulating factor (G-CSF) mobilized marrow and peripheral blood harvests...
February 20, 2018: Transplant Immunology
https://www.readbyqxmd.com/read/29475082/a-rare-case-of-oral-metastasis-of-colon-adenocarcinoma
#8
I Romanet, R Lan, U Ordioni, A F Albertini, F Campana
INTRODUCTION: Metastatic carcinoma of the colon is frequently encountered. In the literature, metastasis of malignant tumors in the buccal cavity are rare. They represent less than 1% of oral malignant lesions. OBSERVATION: We present a case of oral metastasis of colon adenocarcinoma in the mandible of a 62-year-old patient. The physical examination revealed a swelling in the mandibular symphysis associated with dental displacement. The panoramic X-ray showed significant bone lysis of the symphysis...
February 20, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29475080/partial-maxillectomy-for-ameloblastoma-of-the-maxilla-with-infratemporal-fossa-involvement-a-combined-endoscopic-endonasal-and-transoral-approach
#9
Anasuya Guha, Libor Hart, Helena Polachova, Martin Chovanec, Petr Schalek
BACKGROUND: Ameloblastoma represents the most common epithelial odontogenic tumor. Because of the proximity of the maxillary tumors to the orbit and skull base, it should be managed as radically as possible. Maxillectomy mainly via the transfacial or transoral approach represents the most common type of surgical procedure. Drawback of these approaches is limited control of the superiomedial extent of the tumour in the paranasal area. We report the use of a combined endoscopic endonasal and transoral approach to manage maxillary plexiform ameloblastoma in a 48 year old male patient...
February 20, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29475068/acute-subchronic-oral-toxicity-toxicokinetics-and-genotoxicity-studies-of-dfc-2-an-antitubercular-drug-candidate
#10
Hoonhee Seo, Hafij Al Mahmud, Sukyung Kim, Md Imtiazul Islam, Kee-In Lee, Young Sig Gil, Ho-Yeon Song
The infectious disease tuberculosis remains a serious global health issue and is responsible for nearly 1.8 million deaths every year. In our previous study, DFC-2 was confirmed to show anti-tubercular activity against drug-susceptible and drug-resistant strains of Mycobacterium tuberculosis. To support the safety-in-use of DFC-2 as an anti-tubercular drug, DFC-2 was tested via single- and 28-day repeated-dose oral toxicity study and mutagenicity assays. In the oral toxicity study, a single oral dose of DFC-2 at 2000 mg/kg did not produce deaths or abnormal lesions in the internal organs of rats...
February 20, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29474996/considerations-for-exercise-prescription-in-patients-with-bone-metastases-a-comprehensive-narrative-review
#11
REVIEW
Gráinne Sheill, Emer M Guinan, Nicola Peat, Juliette Hussey
Metastatic disease is a frequent complication of advanced cancer, with bone representing one of the most common sites of metastatic occurrence. Patients with bone metastases receive long-term systemic treatments which have a significant attritional impact on muscle strength, fatigue and physical functioning. Physical rehabilitation involving exercise and physical activity prescription has a considerable role in counteracting these changes however exercise is often perceived as a contraindication in the presence of bone metastases due to concerns about aggravating skeletal related events...
February 20, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29474984/chimerism-analysis-in-the-pediatric-setting-direct-pcr-from-bone-marrow-whole-blood-and-cell-fractions
#12
Susanne Kricke, Lana Mhaldien, Rozendo Fernandes, Charizel Villanueva, Alistair Shaw, Paul Veys, Stuart Adams
Certain blood components and anticoagulants interfere with the PCR process and subsequent analysis. Here we demonstrate that reliable test results can be obtained for chimerism analysis despite omitting a DNA extraction step and performing PCR and fragment analysis directly on bone marrow, whole-blood, and individual cell fractions. For chimerism analysis, this is possible with the use of a robust commercially available PCR mix containing a DNA polymerase capable of DNA amplification directly from the sample without the need for pre-treatment...
February 20, 2018: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/29474948/assessment-of-a-press-fit-proximal-femoral-modular-reconstruction-implant-pfmr%C3%A2-at-14-5-years-a-48-case-series-with-a-disturbing-rate-of-implant-fracture
#13
Q Dumoulin, S Sabau, T Goetzmann, A Jacquot, F Sirveaux, D Mole, O Roche
INTRODUCTION: The PFMR® proximal femoral modular reconstruction implant (Protek, Sulzer Orthopedics, Switzerland) is a straight modular stem in sanded titanium with press-fit anchorage, intended to achieve spontaneous bone reconstruction following Wagner's principle. The aim of the present study was to analyze long-term clinical and radiological outcome. MATERIAL AND METHOD: A single-center retrospective study included 48 PFMR stems implanted in 47 patients between 1998 and 2002...
February 20, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29474800/validity-of-the-4-compartment-model-using-dual-energy-x-ray-absorptiometry-derived-body-volume-in-overweight-individuals
#14
Malia N M Blue, Katie R Hirsch, Eric T Trexler, Abbie E Smith-Ryan
The purpose of the present study was to assess the validity of dual-energy X-ray absorptiometry (DXA) to estimate body volume (BV) for use in a four-compartment (4C) body composition model in an overweight/obese population. Body composition of 61 overweight/obese adults (Age: 37.3 ± 10.0 yrs; Height: 170.2 ± 9.5 cm; Body mass: 97.1 ± 17.4 kg) was measured by two methods: a criterion 4C model and a DXA-derived BV 4C model. For both models, bioelectrical impedance spectroscopy was used to estimate total body water; total body bone mineral content was measured by a full body DXA scan...
February 23, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29474789/tissue-and-organ-3d-bioprinting
#15
Min Zeng, Sha Jin, Kaiming Ye
Three-dimensional (3D) bioprinting enables the creation of tissue constructs with heterogeneous compositions and complex architectures. It was initially used for preparing scaffolds for bone tissue engineering. It has recently been adopted to create living tissues, such as cartilage, skin, and heart valve. To facilitate vascularization, hollow channels have been created in the hydrogels by 3D bioprinting. This review discusses the state of the art of the technology, along with a broad range of biomaterials used for 3D bioprinting...
February 1, 2018: SLAS Technology
https://www.readbyqxmd.com/read/29474746/a-systematic-review-of-the-evidence-and-analysis-of-the-consequences
#16
REVIEW
J-Matthias Löhr, Nikola Panic, Miroslav Vujasinovic, Caroline S Verbeke
Senior people constitute the fastest growing segment of the population. The elderly are at risk for malnutrition, thought to be caused by reduced food intake or involution of the physiological capacity of the GI tract. Age-related changes are well known in other secretory organs such as liver, kidney, and intestine. The pancreas, representing a metabolically active organ with uptake and breakdown of essential nutritional components, changes its morphology and function with age. During childhood, the volume of the pancreas increases, reaching a plateau between 20-60 years, and declines thereafter...
February 23, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29474739/mst1-2-kinases-modulate-glucose-uptake-for-osteoblast-differentiation-and-bone-formation
#17
Wenling Li, Yujie Deng, Bo Feng, Kingston King-Lun Mak
Bone formation and bone homeostasis are energy-expensive processes. How they are being regulated by energy needs are not completely understood. This is of high clinical importance as diabetic-induced bone loss is common where the underlying mechanisms are unclear. Here, we show that Mst1/2 are important regulators for glucose uptake during osteoblast differentiation. Genetically removal of both Mst1/2 kinases simultaneously in mice in early and mature osteoblasts respectively inhibits bone formation and bone remodeling...
February 23, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29474577/primary-lymphoma-of-bone
#18
Ravikanth Reddy
No abstract text is available yet for this article.
February 21, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29474543/three-dimensional-evaluation-on-digital-casts-of-maxillary-palatal-size-and-morphology-in-patients-with-functional-posterior-crossbite
#19
Rosalia Leonardi, Antonino Lo Giudice, Michele Rugeri, Simone Muraglie, Giancarlo Cordasco, Ersilia Barbato
Background and objectives: Some authors have recently postulated the possibility of a unilateral contraction of the palate in patients with crossbite. This study aimed to investigate palatal dimension size and morphology in subjects with functional posterior crossbite and to localize location of the contraction through a 3D analysis procedure. Materials and methods: A study sample (SS) of 35 subjects (mean age 9.2 ± 0.8 years), diagnosed with functional crossbite, and a control sample (CS) of 35 subjects (mean age 9...
February 21, 2018: European Journal of Orthodontics
https://www.readbyqxmd.com/read/29474408/molecular-adaptations-to-phosphorus-deprivation-and-comparison-with-nitrogen-deprivation-responses-in-the-diatom-phaeodactylum-tricornutum
#20
Leila Alipanah, Per Winge, Jens Rohloff, Javad Najafi, Tore Brembu, Atle M Bones
Phosphorus, an essential element for all living organisms, is a limiting nutrient in many regions of the ocean due to its fast recycling. Changes in phosphate (Pi) availability in aquatic systems affect diatom growth and productivity. We investigated the early adaptive mechanisms in the marine diatom Phaeodactylum tricornutum to P deprivation using a combination of transcriptomics, metabolomics, physiological and biochemical experiments. Our analysis revealed strong induction of gene expression for proteins involved in phosphate acquisition and scavenging, and down-regulation of processes such as photosynthesis, nitrogen assimilation and nucleic acid and ribosome biosynthesis...
2018: PloS One
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