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https://www.readbyqxmd.com/read/29684943/the-diagnostic-implications-of-two-cases-of-known-rheumatoid-arthritis-from-the-cal-milano-cemetery-skeletal-collection
#1
Lucie Biehler-Gomez, Cristina Cattaneo
Rheumatoid arthritis (RA) is the most common erosive arthropathy and is of particular interest to forensic sciences. However, its diagnosis on bones remains challenging. We examined two skeletons from the CAL Milano Cemetery Skeletal Collection diagnosed with the pathology during life, to test the validity of the diagnostic criteria on bones. The first showed typical lesions of RA described in the literature. The second exhibited secondary osteoarthrosis, suggesting long-standing RA. A differential diagnosis including all four seronegative spondyloarthropathies, erosive osteoarthritis, gout and neuropathic arthropathy was also considered...
April 23, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29684942/reanalysis-of-the-trotter-tibia-quandary-and-its-continued-effect-on-stature-estimation-of-past-conflict-service-members
#2
Jeffrey James Lynch, Carrie Brown, Andrea Palmiotto, Heli Maijanen, Franklin Damann
Forensic casework from past-conflicts relies on the corrected historical Trotter data for stature estimation in Fordisc. For roughly 10 years', stature estimation using this data has produced point estimates for the tibia that are on average 1.25 inches less than the other long bones. This issue was identified after applying the equations derived from Fordisc to the USS Oklahoma commingled assemblage. Reevaluation of Fordisc revealed that a correction factor of 20 mm, instead of 10 mm, was mistakenly applied to the Trotter tibia data...
April 23, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29684935/facial-asymmetry-based-age-group-estimation-role-in-recognizing-age-separated-face-images
#3
Muhammad Sajid, Imtiaz Ahmad Taj, Usama Ijaz Bajwa, Naeem Iqbal Ratyal
Face recognition aims to establish the identity of a person based on facial characteristics. On the other hand, age group estimation is the automatic calculation of an individual's age range based on facial features. Recognizing age-separated face images is still a challenging research problem due to complex aging processes involving different types of facial tissues, skin, fat, muscles, and bones. Certain holistic and local facial features are used to recognize age-separated face images. However, most of the existing methods recognize face images without incorporating the knowledge learned from age group estimation...
April 23, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29684921/clinical-efficacy-of-bone-reconstruction-surgery-with-frozen-cortical-bone-allografts-for-nonunion-of-radial-and-ulnar-fractures-in-toy-breed-dogs
#4
Shuntaro Munakata, Yukari Nagahiro, Daichi Katori, Norihiro Muroi, Hiroyuki Akagi, Nobuo Kanno, Yasuji Harada, Shinya Yamaguchi, Kei Hayashi, Yasushi Hara
OBJECTIVE:  To evaluate the effectiveness of frozen cortical bone allografts (FCBA) in the treatment of severe radial and ulnar atrophic nonunion fractures. ANIMALS:  Toy breed dogs with nonunion of radial and ulnar fractures ( n  = 15). METHODS:  Severe atrophic nonunion fractures were treated with FCBA (eight infected and seven non-infected fractures). Radiographs obtained immediately after surgery, and 1, 2, 3, 6 and 12 months later were evaluated and scored for the periosteal reaction at the bone regeneration sites, the healing process in the bone connection areas at both the proximal and distal sites, and the bone remodelling process within the allografts...
April 23, 2018: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/29684919/clinical-outcomes-and-complications-after-open-reduction-and-internal-fixation-utilizing-conventional-plates-in-65-distal-radial-and-ulnar-fractures-of-miniature-and-toy-breed-dogs
#5
Takeshi Aikawa, Yuta Miyazaki, Taichi Shimatsu, Kyoko Iizuka, Masaaki Nishimura
OBJECTIVE:  This article aims to evaluate clinical outcomes and complications of distal radial and ulnar fractures in miniature- and toy-breed dogs treated with conventional bone plate fixation. METHODS:  Medical records (2001-2010) of miniature- and toy-breed dogs with distal radial and ulnar fractures repaired with open reduction and internal fixation utilizing conventional plates were reviewed. The inclusion criteria were body weight of <7 kg, fracture located in the distal antebrachium (distal-to-total radial length ratio < 0...
April 23, 2018: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/29684872/developmental-toxicity-of-dibutyl-phthalate-and-citrate-ester-plasticizers-in-xenopus-laevis-embryos
#6
Yang Xu, Myung Chan Gye
Citrate esters have been considered as alternatives to phthalate plasticizers. Being considered to have low toxicity in mammals, their toxicological information for aquatic animals remains poorly understood. We examined the developmental toxicity of citrate esters including tributyl O-acetylcitrate (ATBC), triethyl 2-acetylcitrate (ATEC), and trihexyl O-acetylcitrate (ATHC) together with dibutyl phthalate (DBP) based on the frog embryo teratogenesis assay-Xenopus (FETAX). ATBC has the lowest 96 h LC50 and 96 h EC50 values...
April 15, 2018: Chemosphere
https://www.readbyqxmd.com/read/29684814/transcriptional-and-translational-abundance-of-bone-morphogenetic-protein-bmp-2-4-6-7-and-their-receptors-bmpr1a-1b-and-bmpr2-in-buffalo-ovarian-follicle-and-the-role-of-bmp4-and-bmp7-on-estrogen-production-and-survival-of-cultured-granulosa-cells
#7
G Rajesh, S R Mishra, A Paul, M Punetha, G M Vidyalakshmi, K Narayanan, S Bag, S K Bhure, V Singh Chouhan, V P Maurya, G Singh, Mihir Sarkar
BMPs and their receptors modulate the granulosa cell (GC) function in the follicle of domestic animals. Since little is known on BMPs in the buffalo, the present study was aimed to investigate the expression of BMP2, 4, 6, 7 and their receptors BMPR1A, BMPR1B, BMPR2 in the GC and theca cells (TC) of ovarian follicles and the role of BMP4 and BMP7 on buffalo GC. Follicles were classified into four groups based on size and E2 level in the follicular fluid as follows: (i) Group1(4-6 mm; <0.5 ng/mL) (ii) Group 2 (7-9 mm; 0...
April 16, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29684776/cyclic-uniaxial-compression-of-human-stem-cells-seeded-on-a-bone-biomimetic-nanocomposite-decreases-anti-osteogenic-commitment-evoked-by-shear-stress
#8
Walter Baumgartner, Isabelle Schneider, Samuel C Hess, Wendelin J Stark, Sonja Märsmann, Marzia Brunelli, Maurizio Calcagni, Paolo Cinelli, Johanna Buschmann
OBJECTIVE: Chemical supplementation of culture media to induce differentiation of adult stem cells seeded on a scaffold may mask other differentiation triggers such as scaffold stiffness, chemical composition or mechanical stimulation. However, stem cells can be differentiated towards osteoblasts without any supplementation given an appropriate osteogenic scaffold and an adequate mechanical stimulation. MATERIALS AND METHODS: Electrospun meshes of poly-lactic-co-glycolic acid and amorphous calcium phosphate nanoparticles (PLGA/aCaP) in a weight ratio of 60:40 were seeded with human adipose-derived stem cells (ASCs) and cultured in DMEM...
April 5, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29684720/cicer-arietinum-extract-ameliorate-%C3%AE-irradiation-disorders-via-modulation-of-oxidative-antioxidative-pathway
#9
Amany A Sayed, Osama A Abbas, Mona A Saad, Mohamed-Assem S Marie
Ionized radiations trigger thoughtful adverse hazards through multiple organ dysfunctions. Recently, antioxidant-based biodrugs are used to prevent and treat ionizing radiation hazards. The present study aimed to investigate the prospective ameliorative effect of Cicer arietinum extract (CAE) against γ-irradiation and the pathway of this amelioration in male albino rats. Twenty four rats were allocated into four groups; (i) control group, (ii) CAE group in which rats treated with a dosage of 500 mg CAE/kg b...
April 14, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29684676/fabrication-of-nanofibrous-microcarriers-mimicking-extracellular-matrix-for-functional-microtissue-formation-and-cartilage-regeneration
#10
Yansen Wang, Xueling Yuan, Kun Yu, Haoye Meng, Yudong Zheng, Jiang Peng, Shibi Lu, Xiaotong Liu, Yajie Xie, Kun Qiao
Cartilage has rather limited capacities for self-repair and regeneration. To repair complexly shaped cartilage tissue defects, we propose the application of microtissues fabricated from bone marrow-derived mesenchymal stem cells (BMSCs) cultured in natural bionic nanofibrous microcarriers (NF-MCs). The NF-MCs were structurally and functionally designed to mimic natural extracellular matrix (ECM) by crosslinking dialdehyde bacterial cellulose (DBC) with DL-allo-hydroxylysine (DHYL) and complexing chitosan (CS) with DHYL through electrostatic interactions...
April 16, 2018: Biomaterials
https://www.readbyqxmd.com/read/29684652/generosity-and-compliance-recruitment-work-and-the-pathways-to-participation-in-bone-marrow-donation
#11
Kushan Dasgupta
This study examines challenges involved in recruiting bone marrow donors. Data comes from participant observation with a recruitment organization in the United States. Findings reveal that recruiters try to express bone marrow donation with common "gift of life" messaging, which emphasizes a singular event involving generosity. Potential recruits, however, respond by focusing on pain and time commitments. These concerns draw attention to the many stages and requirements involved in bone marrow donation and make issues of compliance salient...
April 12, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29684637/reconstruction-of-condyles-by-transport-distraction-osteogenesis-3-case-report-with-complication-management
#12
Dogan Dolanmaz, Kayhan Ozturk, Mehmet Bahadir Llik, Murat Celik
OBJECTIVE: The aim of this case report is to evaluate the clinical outcomes that including minor postoperative complications of the transport distraction osteogenesis (TDO) for reconstruction of the ramus-condyle unit. STUDY DESIGN: We present 3 cases of the ramus condyle unit reconstruction after the resection of bone tumors. All three bone tumors were excised intraoperatively and the histologic assessment confirmed the clinical diagnosis of osteochondroma, condylar hyperplasia and osteoma...
April 20, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29684621/setd7-and-its-contribution-to-boron-induced-bone-regeneration-in-b-mbg-scaffolds
#13
Chengcheng Yin, Xiaoshi Jia, Richard J Miron, Qiaoyun Long, Hudi Xu, Yan Wei, Min Wu, Yufeng Zhang, Zubing Li
Boron (B), a trace element found in the human body, plays an important role for health of bone by promoting the proliferation and differentiation of osteoblasts. Our research group previously fabricated B-mesoporous bioactive glass (MBG) scaffolds, which successfully promoted osteogenic differentiation of osteoblasts when compared to pure MBG scaffolds without boron. However, the mechanisms of the positive effect of B-MBG scaffolds on osteogenesis remains unknown. Therefore, we performed in-vivo experiments in an OVX rat models with pure MBG scaffolds and compared them to B-MBG scaffold...
April 20, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29684620/in-vivo-quantification-of-hydrogen-gas-concentration-in-bone-marrow-surrounding-magnesium-fracture-fixation-hardware-using-an-electrochemical-hydrogen-gas-sensor
#14
Daoli Zhao, Andrew Brown, Tingting Wang, Sayuri Yoshizawa, Charles Sfeir, William R Heineman
Magnesium (Mg) medical devices are currently being marketed for orthopedic applications and have a complex degradation process which includes the evolution of hydrogen gas (H2 ). The effect of H2 exposure on relevant cell types has not been studied; and the concentration surrounding degrading Mg devices has not been quantified to enable such mechanistic studies. A simple and effective method to measure the concentration of H2 in varying microenvironments surrounding Mg implants is the first step to understanding the biological impact of H2 on these cells...
April 20, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29684562/bmt-following-non-myeloablative-treosulfan-conditioning-is-curative-in-a-murine-model-of-sickle-cell-disease
#15
Divya Devadasan, Chiao-Wang Sun, Erik R Westin, Li-Chen Wu, Kevin M Pawlik, Tim M Townes, Frederick D Goldman
Allogeneic hematopoietic stem cell transplantation (HSCT) can be curative for patients with sickle cell disease (SCD). However, morbidity associated with myeloablative conditioning and graft versus host disease has limited its utility. To this end, autologous HSCT for SCD using lentiviral gene-modified bone marrow (BM) or peripheral blood stem cells has been undertaken, though toxicities of fully ablative conditioning with busulfan and incomplete engraftment have been encountered. Treosulfan, a busulfan analog with a low extra-medullary toxicity profile, has been employed successfully as part of a myeloablative conditioning regimen in the allogeneic setting in SCD...
April 20, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29684521/the-hypoxic-peri-arteriolar-glioma-stem-cell-niche-an-integrated-concept-of-five-types-of-niches-in-human-glioblastoma
#16
REVIEW
Diana A Aderetti, Vashendriya V V Hira, Remco J Molenaar, Cornelis J F van Noorden
Glioblastoma is the most lethal primary brain tumor and poor survival of glioblastoma patients is attributed to the presence of glioma stem cells (GSCs). These therapy-resistant, quiescent and pluripotent cells reside in GSC niches, which are specific microenvironments that protect GSCs against radiotherapy and chemotherapy. We previously showed the existence of hypoxic peri-arteriolar GSC niches in glioblastoma tumor samples. However, other studies have described peri-vascular niches, peri-hypoxic niches, peri-immune niches and extracellular matrix niches of GSCs...
April 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29684481/trabecular-bone-texture-detected-by-plain-radiography-is-associated-with-mri-defined-osteophytes-in-finger-joints-of-women-without-radiographic-osteoarthritis
#17
M Wolski, P Podsiadlo, G W Stachowiak, M Englund, I K Haugen
OBJECTIVE: To examine associations between trabecular bone (TB) texture and MRI-defined osteophytes in finger joints without radiographic osteoarthritis (OA) using an augmented variance orientation transform (AVOT) method. DESIGN: In a cross-sectional study, associations of the TB texture and osteophytes were examined in 21 women with mean (standard deviation) age of 69.9 (5.3) from the Oslo Hand OA cohort. The AVOT was applied to distal and proximal TB regions selected on hand radiographs of the subjects...
April 20, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29684456/radioprotective-effect-of-orally-administered-beta-d-glucan-derived-from-saccharomyces-cerevisiae
#18
Fang Liu, Zhuanzi Wang, Jia Liu, Wenjian Li
The present study was to evaluate the in vivo radioprotective effect of oral administration of Saccharomyces cerevisiae-derived-beta-d-glucan (S. cerevisiae-BG) and to investigate the protective mechanism. The results demonstrated that oral pretreatment with 350 mg/kg S. cerevisiae-BG once daily for 14 consecutive days significantly increased the survival rate of mice from 6 Gy X-rays irradiation. At the 30th day after irradiation, cellularity and the percentage of hematopoietic stem/progenitor cells in bone marrow (BM) of surviving mice were increased by S...
April 20, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29684444/studies-into-slo1-k-channels-and-their-ligand-docosahexaenoic-acid-in-murine-sepsis-to-delineate-off-target-effects-of-immunonutrition
#19
Bianka Wissuwa, Stefan H Heinemann, Michael Bauer, Sina M Coldewey
AIMS: Studies on omega-3 fatty acids, including docosahexaenoic acid (DHA), reveal diverging results: Their intake is recommended in cardiovascular disease and major surgery, while evidence argues against use in septic patients. DHA mediates its blood-pressure-lowering effect through Slo1 channels that are expressed on cardiovascular and immune cells. We hypothesised that conflicting effects of immunonutrition could be explained by the influence of omega-3 fatty acids on systemic blood pressure or immune effector cells through Slo1...
April 20, 2018: Life Sciences
https://www.readbyqxmd.com/read/29684411/hla-a-c-b-drb1-dqb1-and-dpb1-allele-and-haplotype-frequencies-in-4514-healthy-norwegians
#20
Asgeir Lande, Irene Andersen, Torstein Egeland, Benedicte A Lie, Marte K Viken
We report HLA-A, -C, -B, -DRB1, -DQB1 and -DPB1 allele frequencies and estimated haplotype frequencies from 4514 healthy Norwegians who volunteered to participate in the Norwegian Bone Marrow Donor Registry. HLA genotyping was conducted on a Next Generation Sequencing platform. Data were analyzed using Arlequin and Pypop software. No significant deviations from Hardy-Weinberg Equilibrium were noted at any of the loci studied. We discuss the representability for the Norwegian population and argue that the presented HLA data could serve as a Norwegian reference panel...
April 20, 2018: Human Immunology
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