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Spondyloarthropaties

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https://www.readbyqxmd.com/read/27267330/quality-of-life-in-spondyloarthritis-analysis-of-a-large-brazilian-cohort
#1
Sandra L E Ribeiro, Elisa N Albuquerque, Adriana B Bortoluzzo, Célio R Gonçalves, José Antonio Braga da Silva, Antonio Carlos Ximenes, Manoel B Bértolo, Mauro Keiserman, Rita Menin, Thelma L Skare, Sueli Carneiro, Valderílio F Azevedo, Walber P Vieira, Washington A Bianchi, Rubens Bonfiglioli, Cristiano Campanholo, Hellen M S Carvalho, Izaias P Costa, Angela L B Pinto Duarte, Charles L Kohem, Nocy H Leite, Sonia A L Lima, Eduardo S Meirelles, Ivânio A Pereira, Marcelo M Pinheiro, Elizandra Polito, Gustavo G Resende, Francisco Airton C Rocha, Mittermayer B Santiago, Maria de Fátima L C Sauma, Valéria Valim, Percival D Sampaio-Barros
OBJECTIVE: To analyze quality of life and demographic and clinical variables associated to its impairment in a large Brazilian cohort of patients with spondyloarthritis (SpA). METHODS: A common protocol of investigation was applied to 1465 Brazilian patients classified as SpA according to the European Spondyloarthropaties Study Group (ESSG) criteria, attended at 29 reference centers for Rheumatology in Brazil. Clinical and demographic variables were recorded. Quality of life was analyzed through the Ankylosing Spondylitis Quality of Life (ASQoL) questionnaire...
January 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/26239601/-quality-of-life-in-spondyloarthritis-analysis-of-a-large-brazilian-cohort
#2
Sandra L E Ribeiro, Elisa N Albuquerque, Adriana B Bortoluzzo, Célio R Gonçalves, José Antonio Braga da Silva, Antonio Carlos Ximenes, Manoel B Bértolo, Mauro Keiserman, Rita Menin, Thelma L Skare, Sueli Carneiro, Valderílio F Azevedo, Walber P Vieira, Washington A Bianchi, Rubens Bonfiglioli, Cristiano Campanholo, Hellen M S Carvalho, Izaias P Costa, Angela L B Pinto Duarte, Charles L Kohem, Nocy H Leite, Sonia A L Lima, Eduardo S Meirelles, Ivânio A Pereira, Marcelo M Pinheiro, Elizandra Polito, Gustavo G Resende, Francisco Airton C Rocha, Mittermayer B Santiago, Maria de Fátima L C Sauma, Valéria Valim, Percival D Sampaio-Barros
OBJECTIVE: To analyze quality of life and demographic and clinical variables associated to its impairment in a large Brazilian cohort of patients with spondyloarthritis (SpA). METHODS: A common protocol of investigation was applied to 1465 Brazilian patients classified as SpA according to the European Spondyloarthropaties Study Group (ESSG) criteria, attended at 29 reference centers for Rheumatology in Brazil. Clinical and demographic variables were recorded. Quality of life was analyzed through the Ankylosing Spondylitis Quality of Life (ASQoL) questionnaire...
July 17, 2015: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/24365312/rheumatoid-arthritis-spondyloarthropathies-and-relapsing-polychondritis
#3
REVIEW
Rochella A Ostrowski, Troy Takagishi, John Robinson
The neurologic complications of rheumatic disease are highly variable and their manifestations are linked to the pathogenesis and clinical phenotype of the specific rheumatologic syndrome. In active rheumatoid arthritis (RA), the peripheral nervous system is most commonly involved and mononeuritis multiplex, nerve entrapment and vascultitic sensorimotor neuropathy are not uncommon. Central nervous system complications such as pachymeningitis and cerebral vasculitis are rare. TNF blockade therapy of RA is rarely associated with demyelinating syndromes...
2014: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/24338532/autoimmune-diseases-their-pharmacological-treatment-and-the-cardiovascular-system
#4
REVIEW
Marta Jastrzębska, Michael E Czok, Przemysław Guzik
Cardiovascular system involvement is a frequent complication of autoimmune diseases (AD) such as systemic lupus erythematosus, scleroderma, rheumatoid arthritis, spondyloarthropaties or psoriatic arthritis. The most common forms of such involvement are pericarditis, myocarditis, accelerated atherosclerosis resulting in myocardial infarction or stroke, arrhythmias, conduction abnormalities or congestive heart failure. Some of these manifestations may be dramatic in their course and ultimately fatal. The treatment of AD may further affect the cardiovascular system and result in a lower quality of life, higher mortality and increased cost of healthcare...
2013: Cardiology Journal
https://www.readbyqxmd.com/read/22673743/endothelial-dysfunction-in-rheumatic-autoimmune-diseases
#5
REVIEW
Giuseppe Murdaca, Barbara Maria Colombo, Paola Cagnati, Rossella Gulli, Francesca Spanò, Francesco Puppo
Rheumatic autoimmune diseases have been associated with accelerated atherosclerosis and various types of vasculopathies. Atherosclerosis is an inflammatory condition which starts as a "response to injury" favoring endothelial dysfunction which is associated with increased expression of adhesion molecules, pro-inflammatory cytokines, pro-thrombotic factors, oxidative stress upregulation and abnormal vascular tone modulation. Endothelial dysfunction in rheumatic autoimmune diseases involves innate immune responses, including macrophages and dendritic cells expression of scavenger and toll-like receptors for modified or native LDL as well as neutrophil and complement activation, and dysregulation of adaptive immune responses, including proliferation of autoreactive T-helper-1 lymphocytes and defective function of dendritic and regulatory T cells...
October 2012: Atherosclerosis
https://www.readbyqxmd.com/read/22465418/characteristics-of-patients-with-spondyloarthritis-followed-in-rheumatology-units-in-spain-emar-ii-study
#6
José Luis Casals-Sánchez, María Jesús García De Yébenes Prous, Miguel Ángel Descalzo Gallego, Juan Manuel Barrio Olmos, Loreto Carmona Ortells, Cesar Hernández García
OBJECTIVE: To describe the main demographic and clinical features of patients with spondyloarthropaties in Spain. PATIENTS AND METHODS: Review of randomized clinical charts of patients with spondyloarthropaties with at least one visit to the rheumatologist in the previous two years. Information was collected on demographic and clinical data (duration of illness, diagnostic category, disease activity, extrarticular manifestations, comorbidity and work disability)...
May 2012: Reumatología Clinica
https://www.readbyqxmd.com/read/22203094/gender-characterization-in-a-large-series-of-brazilian-patients-with-spondyloarthritis
#7
Hellen M S de Carvalho, Adriana B Bortoluzzo, Célio R Gonçalves, José Antonio Braga da Silva, Antonio Carlos Ximenes, Manoel B Bértolo, Sandra L E Ribeiro, Mauro Keiserman, Rita Menin, Thelma L Skare, Sueli Carneiro, Valderílio F Azevedo, Walber P Vieira, Elisa N Albuquerque, Washington A Bianchi, Rubens Bonfiglioli, Cristiano Campanholo, Izaias P Costa, Angela P Duarte, Maria Bernadete O Gavi, Charles L Kohem, Nocy H Leite, Sonia A L Lima, Eduardo S Meirelles, Ivânio A Pereira, Marcelo M Pinheiro, Elizandra Polito, Gustavo G Resende, Francisco Airton C Rocha, Mittermayer B Santiago, Maria de Fátima L C Sauma, Percival D Sampaio-Barros
An increasing number of women have been diagnosed with spondyloarthritis (SpA) in recent decades. While a few studies have analyzed gender as a prognostic factor of the disease, no studies have addressed this matter with a large number of patients in South America, which is a peculiar region due to its genetic heterogeneity. The aim of the present study was to analyze the influence of gender on disease patterns in a large cohort of Brazilian patients with SpA. A prospective study was carried out involving 1,505 patients [1,090 males (72...
April 2012: Clinical Rheumatology
https://www.readbyqxmd.com/read/21365937/-juvenile-spondyloarthropaties
#8
REVIEW
Lidia Rutkowska-Sak, Iwona Słowińska, Zbigniew Zuber
Epidemiologic, clinical, and genetic studies provide grounds for differentiation of juvenile spondyloarthropathies from other rheumatic diseases. The prevalence of spondyloarthropathies among whites is estimated at 0.7 to 1.2% and the female-to-male ratio is 1:2.5. The current classification of clinically defined and undefined forms of juvenile spondyloarthropathies is presented together with their diagnostic criteria and treatment.
2010: Annales Academiae Medicae Stetinensis
https://www.readbyqxmd.com/read/20015205/evidence-for-the-prevention-of-enthesitis-in-hla-b27-h%C3%AE-2-m-transgenic-rats-treated-with-a-monoclonal-antibody-against-tnf-%C3%AE
#9
Anna Franca Milia, Lidia Ibba-Manneschi, Mirko Manetti, Gemma Benelli, Sergio Generini, Luca Messerini, Marco Matucci-Cerinic
Transgenic rats with high expression of HLA-B27 and human β(2) -microglobulin (B27TR) develop a multisystem inflammatory disease resembling human inflammatory bowel disease (IBD) and spondyloarthropaties (SpA). Tumour necrosis factor α (TNF-α) has a crucial role in sustaining chronic inflammation in the gut and joints. The aim of this work was to evaluate whether TNF-α blockade could prevent or reduce the inflammation of peripheral joints in B27TR. A first group of 9-week-old B27TR received an anti-TNF-α monoclonal antibody (mAb) or an isotypic IgG2a,k up to the age of 18 weeks...
February 2011: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/19604431/imaging-of-sternocostoclavicular-joint-in-spondyloarthropaties-and-other-rheumatic-conditions
#10
G Guglielmi, A Cascavilla, G Scalzo, F Salaffi, W Grassi
OBJECTIVE: To retrospectively evaluate the role of the various imaging techniques in the study of the sternocostoclavicular joint, in patients with spondyloarthropathies and other rheumatic conditions and to assess potential pitfalls in the radiological diagnosis. SUBJECTS AND METHODS: Thirty patients, 11 male and 19 female, mean age 45 years, with involvement of the sternocostoclavicular joint as part of rheumatologic disorders (psoriatic arthritis, ankylosing spondylitis, Tietze syndrome, SAPHO syndrome, and condensing osteitis of the clavicle) were studied...
May 2009: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/19169297/-articular-diseases-and-uveitis
#11
REVIEW
J M Benítez Del Castillo, D Díaz-Valle, E Pato, C López-Abad, N Alejandre
Ocular inflammation is a common clinical manifestation related to several autoimmune systemic disorders, specially spondyloarthropaties. In this group, there are different clinical diseases that are related to special uveitic patterns. Several discriminative patterns have been defined that closely link uveitis with certain systemic or ophthalmic diseases. Unilateral recurrent anterior acute uveitis is the most frequent form of uveitis related to spondyloarthropaties, and is sometimes the initial manifestation of an undiagnosed spondyloarthropaty...
2008: Anales del Sistema Sanitario de Navarra
https://www.readbyqxmd.com/read/18468425/-antibodies-to-klebsiella-o-antigens-in-patients-with-seronegative-spondyloarthropaties
#12
Beata Nowak, Marcin Kowalski, Beata Maczyrńska, Jacek Szechiński, Anna Przondo-Mordarska
OBJECTIVES: The pathogenesis of seronegative spondyloarthropathies is still unknown. A microbial etiology has been suggested. The aim of the study was to analyze the antibodies against Klebsiella O-antigens in serum of patients with seronegative spondyloarthropathies. METHODS: 30 patients with seronegative spondyloarthropathies, 20 with rheumatoid arthritis and 20 healthy volunteers were included in the study. The serum antibodies against Klebsiella O1 and O3 antigens were analyzed by enzyme-linked immunosorbent assay (ELISA)...
March 2006: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/17785321/performance-of-antinuclear-antibody-connective-tissue-disease-screen
#13
Marcos López-Hoyos, Vicente Rodríguez-Valverde, Victor Martinez-Taboada
Antinuclear antibodies (ANAs) have become routine laboratory parameters in clinical hospitals. However, ANA testing by indirect immunofluorescence (IIF) assays is not an automated laboratory test. Efforts are being made to develop easy and semi- or automated methods to screen for ANAs. We evaluated the clinical performance of a new ELISA developed to screen for connective tissue disease related ANAs. The presence of serum ANA was studied with a commercial ELISA (Varelisa ANA CTD Screen) in 472 patients (202 SLE, 41 Sjögren syndrome, 11 CREST, 59 rheumatoid arthritis, 30 seronegative spondyloarthropaties, 77 inflammatory bowel disease, 13 reactive arthritis, 11 giant cell arteritis, 28 ankylosing spondilitis)...
August 2007: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/17207391/molecular-mechanisms-in-normal-pregnancy-and-rheumatic-diseases
#14
REVIEW
M Vázquez-Del Mercado, B T Martín-Márquez, M H Petri, E A Martínez-García, J F Muñoz-Valle
Pregnancy is a phenomenon that is not totally understood, based on the complex molecular interactions between the mother and the embrio. Once the fecundation is completed the fetus starts to fight for survival. The first challenge is the implantation process and the second one is the interaction with the maternal immune system. This review discusses how the fetus avoids the immune system rejection, and the mechanisms that the maternal immune system adapts in order to be fit for a successful pregnancy. Also, we focus in this paper on the effects of pregnancy in rheumatic diseases, because the myriad clinical outcomes of the disease itself and the obstetric complications dependent of the disease implicated, as for example in rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), spondyloarthropaties and antiphospholipid syndrome (APS)...
November 2006: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/15554374/-spondyloarthropathies-clinical-evaluation-and-physical-therapy
#15
REVIEW
Tonko Vlak
Spondyloarthropathy is a group of chronic autoimmune disorders including ankylosing spondylitis, reactive arthritis, psoriatic arthritis, arthritis associated with inflammatory bowel disease, acute anterior uveitis and undifferentiated spondyloarthropathies. The spondyloarthropathies share common clinical, radiological, and genetic features that are clearly distinct from other inflammatory rheumatic diseases. The major goal in the management of patients with rheumatic disorders is to control or cure the disease and to preserve and control function and health status...
2004: Reumatizam
https://www.readbyqxmd.com/read/15554371/-early-diagnosis-of-axial-spondyloarthropaties
#16
REVIEW
Bozidar Curković
Spondyloarthropaties are the group of seronegative inflammatory rheumatic diseases affecting axial and perpendicular skelet. Most of the patients belong to the work active population and the longterm prognosis and outcome is poor. The diagnosis of ankylosing spondylitis is delayed over years, sometimes decades. Our perception of spondyloarthropaties todays is changing. Early diagnosis and agressive treatment could influence to prognosis and outcome. For these purposes we have new diagnostic techniques and new potent drugs...
2004: Reumatizam
https://www.readbyqxmd.com/read/12794368/-mycoplasmal-infection-in-patients-with-reactive-arthritis-and-seronegative-spondyloarthropaties
#17
COMPARATIVE STUDY
Irena Butrimiene, Jelena Ranceva, Algimantas Griskevicius
After investigation of 150 patients with reactive arthritis and undifferentiated spondyloarthropathies, inflammation signs of urogenital tract (uretritis in men and endocervicitis in women) were found in about 2/3 of patients. In those patients with reactive arthritis and undifferentiated spondyloarthropathies Ureaplazma urealyticum was found in more than 1/4 of patients, Mycoplasma hominis - in 1/10 of patients, and both microbes appeared in 1/10 of patients. Micoplasmal infection occurred in equal frequency in patients with reactive arthritis and undifferentiated spondyloarthropathies with a tendency to appear more in women than in men...
2003: Medicina
https://www.readbyqxmd.com/read/11723501/-clinical-features-of-spondyloarthropaties-in-childhood-analysis-of-26-patients
#18
P C Faustino, M T Terreri, C T Andrade, C Len, M O Hilário
OBJECTIVE: To evaluate retrospectively the clinical features of children and adolescents with spondiloarthropathies (Sps). METHODS: The charts of all Sps patients followed up in the outpatient Pediatric Rheumatology unit of UNIFESP-EPM, were analyzed from June 1982 to April 2000. The following demographic data were evaluated: age of onset, disease duration, clinical features, laboratory data, radiological findings, treatment and outcome. RESULTS: 10 out of 26 patients (38...
July 2001: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/9045906/susceptibility-to-ankylosing-spondylitis-correlates-with-the-c-terminal-residue-of-peptides-presented-by-various-hla-b27-subtypes
#19
M T Fiorillo, L Meadows, M D'Amato, J Shabanowitz, D F Hunt, E Appella, R Sorrentino
Susceptibility to spondyloarthropaties is strongly associated with some HLA-B27 alleles. Evidence suggests a direct pathogenic role for the B27 molecules which possibly present an arthritogenic peptide to the T cells. If this hypothesis is true, B27 subtypes that differ structurally but are disease-associated ought to be capable of presenting such peptide(s), while non-disease-associated ones would not. We have recently described a B27 subtype, B*2709, and shown its absence in ankylosing spondylitis (AS) patients...
February 1997: European Journal of Immunology
https://www.readbyqxmd.com/read/8544721/-echocardiography-in-the-evaluation-of-cardiac-involvement-in-seronegative-spondylo-arthropathies
#20
F A de Almeida, F M Albanesi Filho, E M de Albuquerque, E C Magalhaes, M E de Menezes
To evaluate the involvement of the heart in patients with seronegative spondyloarthropathies by echodopplercardiography, 35 patients including 20 with ankylosing spondylitis, 10 with Reiter's syndrome and 5 with psoriatic arthritis (21 men and 14 women, with ages ranging from 17-68 years and averaging 38.5) were studied. Most were asymptomatic with respect to the cardiovascular system (65.71%) and 12 oligosymptomatic with palpitations as their main complaint. Each patient had an echocardiogram and electrocardiogram...
1995: Medicina
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