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https://www.readbyqxmd.com/read/27921244/towards-green-oviposition-deterrents-effectiveness-of-syzygium-lanceolatum-myrtaceae-essential-oil-against-six-mosquito-vectors-and-impact-on-four-aquatic-biological-control-agents
#1
Giovanni Benelli, Mohan Rajeswary, Marimuthu Govindarajan
Essential oils (EOs) from plants may be alternative sources of molecules toxic against mosquito vectors of public health relevance. Most of researches in this field focused on EOs as larvicides or ovicides, while limited efforts focused on the exploitation of EOs as oviposition deterrents. In the present study, the larvicidal and oviposition deterrent activity of Syzygium lanceolatum leaf EO was evaluated against six mosquito species, Anopheles stephensi, An. subpictus, Aedes aegypti, Ae. albopictus, Culex quinquefasciatus, and Cx...
December 5, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27919222/capsaicin-8-patch-repeat-treatment-plus-standard-of-care-soc-versus-soc-alone-in-painful-diabetic-peripheral-neuropathy-a-randomised-52-week-open-label-safety-study
#2
Aaron I Vinik, Serge Perrot, Etta J Vinik, Ladislav Pazdera, Hélène Jacobs, Malcolm Stoker, Stephen K Long, Robert J Snijder, Marjolijne van der Stoep, Enrique Ortega, Nathaniel Katz
BACKGROUND: This 52-week study evaluated the long-term safety and tolerability of capsaicin 8% w/w (179 mg) patch repeat treatment plus standard of care (SOC) versus SOC alone in painful diabetic peripheral neuropathy (PDPN). METHODS: Phase 3, multinational, open-label, randomised, controlled, 52-week safety study, conducted in Europe. Patients were randomised to capsaicin 8% patch repeat treatment (30 or 60 min; 1-7 treatments with ≥ 8-week intervals) to painful areas of the feet plus SOC, or SOC alone...
December 6, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27907137/voltage-gated-na-channel-isoforms-and-their-mrna-expression-levels-and-protein-abundance-in-three-electric-organs-and-the-skeletal-muscle-of-the-electric-eel-electrophorus-electricus
#3
Biyun Ching, Jia M Woo, Kum C Hiong, Mel V Boo, Wai P Wong, Shit F Chew, Yuen K Ip
This study aimed to obtain the coding cDNA sequences of voltage-gated Na+ channel (scn) α-subunit (scna) and β-subunit (scnb) isoforms from, and to quantify their transcript levels in, the main electric organ (EO), Hunter's EO, Sach's EO and the skeletal muscle (SM) of the electric eel, Electrophorus electricus, which can generate both high and low voltage electric organ discharges (EODs). The full coding sequences of two scna (scn4aa and scn4ab) and three scnb (scn1b, scn2b and scn4b) were identified for the first time (except scn4aa) in E...
2016: PloS One
https://www.readbyqxmd.com/read/27905512/plant-phenolic-volatiles-inhibit-quorum-sensing-in-pectobacteria-and-reduce-their-virulence-by-potential-binding-to-expi-and-expr-proteins
#4
Janak Raj Joshi, Netaly Khazanov, Hanoch Senderowitz, Saul Burdman, Alexander Lipsky, Iris Yedidia
Quorum sensing (QS) is a population density-dependent regulatory system in bacteria that couples gene expression to cell density through accumulation of diffusible signaling molecules. Pectobacteria are causal agents of soft rot disease in a range of economically important crops. They rely on QS to coordinate their main virulence factor, production of plant cell wall degrading enzymes (PCWDEs). Plants have evolved an array of antimicrobial compounds to anticipate and cope with pathogens, of which essential oils (EOs) are widely recognized...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905068/inhibition-of-mevalonate-pathway-and-synthesis-of-the-storage-lipids-in-human-liver-derived-and-non-liver-cell-lines-by-lippia-alba-essential-oils
#5
Sandra Montero-Villegas, Mónica Polo, Marianela Galle, Boris Rodenak-Kladniew, María Castro, Ana Ves-Losada, Rosana Crespo, Margarita García de Bravo
The essential oils (EOs) of Lippia alba, an herb extensively used as a folk medicine in Latin America, are today promoted as an effective means of eliminating problems caused by hyperlipemia. We hypothesized that L.alba EOs inhibited cholesterol and triacylglycerols synthesis and decreased the intracellular depots of those lipids (lipid droplets), mechanisms involving the induction of a hypolipidemic response. Our aim was, therefore, to evaluate the hypolipogenic capability of the EOs of four L. alba chemotypes on liver-derived (HepG2) and non-liver (A549) human cell lines and to identify the potential biochemical targets of those chemotypes, particularly within the mevalonate pathway (MP)...
November 30, 2016: Lipids
https://www.readbyqxmd.com/read/27894288/bactericidal-and-antioxidant-properties-of-essential-oils-from-the-fruits-dennettia-tripetala-g-baker
#6
Sunday O Okoh, Benson C Iweriegbor, Omobola O Okoh, Uchechukwu U Nwodo, Anthony I Okoh
BACKGROUND: The antibacterial and antioxidant properties of the essential oils (EOs) of unripe and ripe fruits of Dennettia tripetala and their potential for the management of infectious and oxidative-stress diseases were investigated in-vitro in this study. METHOD: Essential oil obtained from the fruit in Clevenger modified apparatus, was characterized by high resolution GC-MS, while antioxidant and antibacterial properties were tested by spectrophotometric and agar diffusion methods respectively...
November 28, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27894050/successful-application-of-a-neutral-organic-base-1-8-bis-tetramethylguanidino-naphthalene-tmgn-for-the-radiosynthesis-of-11-c-raclopride
#7
Jihye Lee, Il-Koo Cheong, Sang-Yoon Lee
[(11)C]Raclopride is one of the most popular PET tracers used in Parkinson's disease studies. We previously prepared [(11)C]raclopride with reasonable yields using NaOH as an inorganic base, but the reaction patterns fluctuated. In this study, we describe the successful application of a commercially available 'super basic' proton sponge, TMGN, as a base for the [(11)C]methylation step using [(11)C]CH3OTf. This novel TMGN method produced better radiochemical yields, as well as enhanced reproducibility and a reduction in side products...
October 11, 2016: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/27889574/budesonide-oral-suspension-improves-symptomatic-endoscopic-and-histologic-parameters-compared-with-placebo-in-patients-with-eosinophilic-esophagitis
#8
Evan S Dellon, David A Katzka, Margaret H Collins, Mohamed Hamdani, Sandeep K Gupta, Ikuo Hirano
BACKGROUND & AIMS: Pharmacologic treatment of eosinophilic esophagitis (EoE) is limited to off-label use of corticosteroids not optimized for esophageal delivery. We performed a randomized, controlled phase 2 trial to assess the ability of budesonide oral suspension (BOS), a novel muco-adherent topical steroid formulation, to reduce symptoms and esophageal eosinophilia in adolescents and adults with EoE. METHODS: In this multicenter, randomized, double-blind, placebo-controlled, parallel-group trial, 93 EoE patients between the ages of 11 and 40 years with dysphagia and active esophageal eosinophilia were randomized to receive either BOS 2 mg or placebo twice daily for 12 weeks...
November 23, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27885827/a-mathematical-modeling-approach-to-understanding-the-effect-of-anti-interleukin-therapy-on-eosinophils
#9
T Karelina, V Voronova, O Demin, G Colice, B M Agoram
Emerging T-helper type 2 (Th2 ) cytokine-based asthma therapies, such as tralokinumab, lebrikizumab (anti-interleukin (IL)-13), and mepolizumab (anti-IL-5), have shown differences in their blood eosinophil (EOS) response. To better understand these effects, we developed a mathematical model of EOS dynamics. For the anti-IL-13 therapies, lebrikizumab and tralokinumab, the model predicted an increase of 30% and 10% in total and activated EOS in the blood, respectively, and a decrease in the total and activated EOS in the airways...
November 2016: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/27884782/is-the-plant-associated-microbiota-of-thymus-spp-adapted-to-plant-essential-oil
#10
Alice Checcucci, Isabel Maida, Giovanni Bacci, Cristina Ninno, Anna Rita Bilia, Sauro Biffi, Fabio Firenzuoli, Guido Flamini, Renato Fani, Alessio Mengoni
We examined whether the microbiota of two related aromatic thyme species, Thymus vulgaris and Thymus citriodorus, differs in relation to the composition of the respective essential oil (EO). A total of 576 bacterial isolates were obtained from three districts (leaves, roots and rhizospheric soil). They were taxonomically characterized and inspected for tolerance to the EO from the two thyme species. A district-related taxonomic pattern was found. In particular, high taxonomic diversity among the isolates from leaves was detected...
November 21, 2016: Research in Microbiology
https://www.readbyqxmd.com/read/27883297/patients-perception-of-parkinson-s-disease-associated-pain-following-initiation-of-rotigotine-a-multicenter-non-interventional-study
#11
Lars Timmermann, Christian Oehlwein, Gerhard Ransmayr, Holger Fröhlich, Edgar Will, Hanna Schroeder, Thomas Lauterbach, Lars Bauer, Jan Kassubek
OBJECTIVES: To evaluate Parkinson's disease (PD)-associated pain as perceived by the patients (subjective characterization), and how this may change following initiation of rotigotine transdermal patch. METHODS: SP1058 was a non-interventional study conducted in routine clinical practice in Germany and Austria in patients experiencing PD-associated pain (per the physician's assessment). Data were collected at baseline (ie, before rotigotine initiation) and at a routine visit after ≥25 days (-3 days allowed) of treatment on a maintenance dose of rotigotine (end of study [EoS])...
November 24, 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27881135/cat-s-whiskers-orthosiphon-stamineus-tea-modulates-arthritis-pathogenesis-via-the-angiogenesis-and-inflammatory-cascade
#12
Yasser M Tabana, Fouad Saleih R Al-Suede, Mohamed B Khadeer Ahamed, Saad S Dahham, Loiy E Ahmed Hassan, Saba Khalilpour, Mohamad Taleb-Agha, Doblin Sandai, Aman S Abdul Majid, Amin Malik Shah Abdul Majid
BACKGROUND: Orthosiphon stamineus is used traditionally to treat gout, arthritis, and inflammatory related conditions. The in vitro anti-inflammatory effects of the plant have been scientifically investigated. The goal of the present study was to evaluate the potential of the 50% ethanol extract of O. stamineus (EOS) to treat rheumatoid arthritis. METHODS: Anti-arthritic activity was assessed using the in vitro heat denaturation test and the (FCA)-induced arthritis model...
November 24, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27875686/early-onset-neonatal-sepsis-and-the-implementation-of-group-b-streptococcus-prophylaxis-in-a-brazilian-maternity-hospital-a-descriptive-study
#13
Felipe Teixeira de Mello Freitas, Gustavo Adolfo Sierra Romero
OBJECTIVES: To describe early-onset neonatal sepsis (EOS) epidemiology in a public maternity hospital in Brasilia, Brazil. METHODS: We defined EOS as a positive blood culture result obtained from infants aged ≤72h plus treatment with antibiotic therapy for ≥5 days. Incidence was calculated based on the number of cases and total live births (LB). This is a descriptive study comparing the period of 2012-2013 with the period of 2014-September 2015, before and after implementation of antibiotic prophylaxis during labor for group B streptococcus (GBS) prevention, respectively...
November 19, 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27872823/serial-physical-examinations-a-simple-and-reliable-tool-for-managing-neonates-at-risk-for-early-onset-sepsis
#14
Alberto Berardi, Anna Maria Buffagni, Cecilia Rossi, Eleonora Vaccina, Chiara Cattelani, Lucia Gambini, Federica Baccilieri, Francesca Varioli, Fabrizio Ferrari
AIM: To investigate whether serial physical examinations (SPEs) are a safe tool for managing neonates at risk for early-onset sepsis (EOS). METHODS: This is a retrospective cohort study of neonates (≥ 34 wks' gestation) delivered in three high-volume level IIIbirthing centres in Emilia-Romagna (Italy) during a 4-mo period (from September 1 to December 31, 2015). Neonates at risk for EOS were managed according to the SPEs strategy, these were carried out in turn by bedside nursing staff and physicians...
November 8, 2016: World Journal of Clinical Pediatrics
https://www.readbyqxmd.com/read/27869257/scaling-relationships-for-nonadiabatic-energy-relaxation-times-in-warm-dense-matter-toward-understanding-the-equation-of-state
#15
Ekadashi Pradhan, Rudolph J Magyar, Alexey V Akimov
Understanding the dynamics of electron-ion energy transfer in warm dense (WD) matter is important to the measurement of equation of state (EOS) properties and for understanding the energy balance in dynamic simulations. In this work, we present a comprehensive investigation of nonadiabatic electron relaxation and thermal excitation dynamics in aluminum under high pressure and temperature. Using quantum-classical trajectory surface hopping approaches, we examine the role of nonadiabatic couplings and electronic decoherence in electron-nuclear energy transfer in WD aluminum...
November 30, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27866540/-the-study-of-the-eosinophil-cd34-progenitor-cells-differentiation-mechanism-of-model-rats-with-occupational-asthma-and-the-intervention-of-warm-and-tonifying-kidney-yang-decoction
#16
Z Y Hu, Y M Jia, S J Wang, J Y Han, T Yu
Objective: To investigate the mechanism of CD34(+) progenitor cell differentiation in rat by observing the change relations between the eosinophils (EOS) and the content of Eotaxin and IL-5 in blood and the CD34(+)/CCR3(+), CD34(+)/IL-5Rα+ in bone marrow after occupational asthma (OA) model rats are simulated, and to observe the effect of WTKYD Trraitional Chinese Medicine intervention. Methods: A total of 40 healthy male SD model rats (200~250 g weight) were randomly divided into model contrast Group, prednisone acetate intervention Group, WTKYD+1/2 prednisone acetate intervention Group and WTKYD intervention Group, 10 in each group, and set a Group for blank contrast...
September 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27858868/serum-bile-acids-in-term-and-preterm-neonates-a-case-control-study-determining-reference-values-and-the-influence-of-early-onset-sepsis
#17
Evelyn Zöhrer, Bernhard Resch, Hubert Scharnagl, Axel Schlagenhauf, Günter Fauler, Tatjana Stojakovic, Nora Hofer, Uwe Lang, Jörg Jahnel
Serum bile acids (BA) reference values are lacking for neonates. Therefore, this study aimed to determine serum BA reference values in term and preterm neonates. Furthermore, as serum BA concentrations are well-known to rise in septic adults, BA values were determined in early-onset neonatal sepsis (EOS), a common and serious disease in neonates.Using high-performance liquid chromatography-high-resolution mass spectrometry (HPLC-HRMS), we profiled serum BA in 236 infants, including healthy term neonates (n = 84), premature infants (n = 101), and both term infants (n = 35) and preterm infants (n = 16) with EOS...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27854109/effect-of-mono-or-bisegmental-lordosizing-fusion-on-short-term-global-and-index-sagittal-balance-a-radiographic-study
#18
Enrico Tessitore, Ilaria Melloni, Oliver P Gautschi, Gianluigi Zona, Karl Schaller, Pedro Berjano
BACKGROUND: Sagittal balance is widely recognized as an important outcome factor in reconstructive spinal surgery for lumbar degenerative conditions. However, its role in short segmental fixation is unknown. The aim of this study is to evaluate the preoperative and short-term postoperative spino-pelvic balance after short (1 or 2 levels) lordosizing lumbar fusion for degenerative disc disease (DDD). MATERIALS AND METHODS: Twenty-six consecutive patients (13 males and 13 females) undergoing mono- or bisegmental lordosizing lumbar fusion (XLIF/TLIF) for lumbar DDD were included in the study...
November 17, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27853710/thymus-vulgaris-red-thyme-and-caryophyllus-aromaticus-clove-essential-oils-to-control-spoilage-microorganisms-in-pork-under-modified-atmosphere
#19
Serena D'Amato, Giovanni Mazzarrino, Chiara Rossi, Annalisa Serio, Clemencia Chaves López, Gaetano Vitale Celano, Antonello Paparella
In recent years, it has been confirmed that essential oils (EOs) exert antimicrobial activity as they are able to inhibit cell growth and inactivate microbial cells. The application of biopreservation strategies by means of EOs opens up interesting perspectives in the food industry, including meat production. The paper aims to evaluate the effects of Thymus vulgaris (red thyme) and Caryophyllus aromaticus (cloves) EOs on the development of the spoilage population of fresh pork packaged under modified atmosphere (MAP)...
June 3, 2016: Italian Journal of Food Safety
https://www.readbyqxmd.com/read/27853024/extraskeletal-osteosarcoma-of-the-orbit-a-clinicopathologic-case-report-and-review-of-literature
#20
V M D S de Maeyer, P A F A Kestelyn, Akash D Shah, C M Van Den Broecke, H G N Denys, C E Decock
Primary extraskeletal osteosarcoma (EOS) is an extremely rare malignancy. In this report, the clinical course of a 32-year-old man presenting with proptoses is described. Medical history included Hirschsprung disease (HD), horseshoe kidney, azoospermia, and vertebral anomalies. Imaging of the orbit showed an oval, well-defined heterogeneous mass adjacent to the lateral wall of the orbit. The patient underwent a lateral orbitotomy and complete excision of the mass. The mass was not attached to the bone. Histopathologic and immunohistochemical examination confirmed the diagnosis of an EOS...
September 2016: Indian Journal of Ophthalmology
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