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https://www.readbyqxmd.com/read/28239078/clinical-outcomes-of-dilation-therapy-for-anastomotic-esophageal-stricture
#1
Cheol Woong Choi, Dae Hwan Kang, Hyung Wook Kim, Su Bum Park, Su Jin Kim, Hyeong Seok Nam, Dae Gon Ryu
Background/Aims: Benign esophageal stricture after esophagectomy is not an infrequent complication. Anastomotic esophageal stricture requires frequent multiple dilations. We aimed to evaluate the clinical outcomes of dilation therapies using an endoscopic balloon or bougie dilator and analyzed the risk factors associated with refractory stricture. Methods: Between January 2009 and May 2016, the medical records of 21 patients treated with endoscopic balloon dilation or bougie dilation for esophageal anastomotic strictures were retrospectively reviewed...
February 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28238953/cost-effectiveness-of-screening-patients-with-gastroesophageal-reflux-disease-for-barrett-s-esophagus-with-a-minimally-invasive-cell-sampling-device
#2
Curtis R Heberle, Amir-Houshang Omidvari, Ayman Ali, Sonja Kroep, Chung Yin Kong, John M Inadomi, Joel H Rubenstein, Angela C Tramontano, Emily C Dowling, William D Hazelton, E Georg Luebeck, Iris Lansdorp-Vogelaar, Chin Hur
BACKGROUND & AIMS: It is important to identify patients with Barrett's esophagus (BE), the precursor to esophageal adenocarcinoma (EAC). Patients with BE are usually identified by endoscopy, which is expensive. The cytosponge, which collects tissue from the esophagus non-invasively, could be a cost-effective tool for screening individuals with gastroesophageal reflux disease (GERD), who are at increased risk for BE. We developed a model to analyze the cost effectiveness of using cytosponge in first-line screening of patients with GERD for BE with endoscopic confirmation, compared to endoscopy screening only, METHODS: We incorporated data from a large clinical trial of cytosponge performance into 2 validated microsimulation models of EAC progression (the esophageal adenocarcinoma model from the Massachusetts General Hospital and the microsimulation screening analysis model from Erasmus University Medical Center)...
February 23, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28238770/association-between-screen-detected-gallstone-disease-and-cancer-in-a-cohort-study
#3
Daniel Mønsted Shabanzadeh, Lars Tue Sørensen, Torben Jørgensen
BACKGROUND & AIMS: Knowledge of temporal associations between screen-detected gallstone disease and specific cancers is limited. The objective of this study was to determine if screen-detected gallstones or cholecystectomy is associated with occurrence of gastrointestinal and non-gastrointestinal cancers. METHODS: We performed a cohort study of 3 randomly selected groups from the general population of Copenhagen. Participants (n=5928) were examined from 1982 through 1992 and underwent abdominal ultrasound examination to detect gallstone disease, but were not informed of their gallstone status...
February 23, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28238716/bullous-pemphigoid-extensive-esophageal-involvement
#4
R Gaspar, P Moutinho-Ribeiro, G Macedo
No abstract text is available yet for this article.
February 23, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28238078/phase-i-study-of-pazopanib-plus-th-302-in-advanced-solid-tumors
#5
Richard F Riedel, Kellen L Meadows, Paula H Lee, Michael A Morse, Hope E Uronis, Gerard C Blobe, Daniel J George, Jeffrey Crawford, Donna Niedzwiecki, Christel N Rushing, Christy C Arrowood, Herbert I Hurwitz
PURPOSE: To define the maximum tolerated dose (MTD), recommended phase II dose (RPTD), and assess safety and tolerability for the combination of pazopanib plus TH-302, an investigational hypoxia-activated prodrug (HAP), in adult patients with advanced solid tumors. METHODS: This was an open-label, non-randomized, single-center, phase I trial consisting 2 stages. Stage 1 was a standard "3 + 3" dose escalation design to determine safety and the RPTD for TH-302 plus pazopanib combination...
February 25, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28237393/angiolipoma-a-rare-esophageal-submucosal-tumor
#6
Xiaoyu Tang, Yuyong Tan, Deliang Liu
No abstract text is available yet for this article.
February 22, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28237379/readmission-after-gastrointestinal-bleeding-in-children-a-retrospective-cohort-study
#7
Thomas M Attard, Mikaela Miller, Chaitanya Pant, Mike Thomson
INTRODUCTION: To compare the demographic, clinical, and therapeutic characteristics in a cohort of patients discharged following acute gastrointestinal bleeding, representing to the emergency department (ED) and readmitted within 30 days of discharge with the characteristics of non-readmitted patients. STUDY DESIGN: Hospitalization data was obtained from the Pediatric Hospital Information System including 49 tertiary children's hospitals in the US. Children 1-21 years of age diagnosed with acute gastrointestinal bleeding, admitted between January 2007 and September 2015 were included...
February 23, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28237293/method-of-predicting-the-mean-lung-dose-based-on-a-patient-s-anatomy-and-dose-volume-histograms
#8
Anna Zawadzka, Marta Nesteruk, Beata Brzozowska, Paweł F Kukołowicz
The aim of this study was to propose a method to predict the minimum achievable mean lung dose (MLD) and corresponding dosimetric parameters for organs-at-risk (OAR) based on individual patient anatomy. For each patient, the dose for 36 equidistant individual multileaf collimator shaped fields in the treatment planning system (TPS) was calculated. Based on these dose matrices, the MLD for each patient was predicted by the homemade DosePredictor software in which the solution of linear equations was implemented...
April 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28236016/fully-covered-stents-are-similar-to-semi-covered-stents-with-regard-to-migration-in-palliative-treatment-of-malignant-strictures-of-the-esophagus-and-gastric-cardia-results-of-a-randomized-controlled-trial
#9
Jan Persson, Ulrika Smedh, Åse Johnsson, Bo Ohlin, Magnus Sundbom, Magnus Nilsson, Lars Lundell, Berit Sund, Erik Johnsson
INTRODUCTION: Stent migration is a significant clinical problem in palliation of malignant strictures in the esophagus and gastro-esophageal junction (GEJ). We have compared a newer design of a fully-covered stent to a widely used semi-covered stent using migration >20 mm as the primary outcome variable. Effects on dysphagia, quality of life (QoL) and re-intervention frequency were also investigated. METHODS: Patients with dysphagia due to non-curable esophagus/GEJ cancer were randomized to receive either a more recent design of a fully-covered stent (n = 48) or a conventional semi-covered stent (n = 47)...
February 24, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28235713/gastroesophageal-reflux-is-not-associated-with-short-term-variability-of-parasympathetic-activity-in-children
#10
Jan Krzysztof Nowak, Agata Łaźniak, Aleksandra Lisowska, Zdzisława Kycler, Waldemar Bobkowski, Jarosław Walkowiak
PURPOSE: A lower parasympathetic activity was described in patients with the gastroesophageal reflux disease. We aimed to determine whether gastroesophageal reflux (GER) episodes are associated with a short-term parasympathetic tone variability in children. METHODS: In order to address this question we performed simultaneous 24-h esophageal multichannel intraluminal impedance-pH and electrocardiographic monitoring in 16 children (age range 6-18 years), including 8 with asthma and 2 with gastroesophageal reflux disease...
February 21, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28235650/esophageal-adenocarcinoma-five-years-after-laparoscopic-sleeve-gastrectomy-a-case-report
#11
Fernando Gabriel Wright, Agustin Duro, Juan Rodolfo Medici, Santiago Lenzi, Axel Federico Beskow, Demetrio Cavadas
INTRODUCTION: Laparoscopic sleeve gastrectomy has become the most popular bariatric procedure worldwide. However, postoperative gastroesophageal reflux disease appearance is a matter of concern. Only two cases of esophageal adenocarcinoma after gastric sleeve have been described, none of them with preoperative endoscopic evaluation. PRESENTATION OF CASE: We report a case of a 48-year-old male with morbid obesity and normal preoperative endoscopy and esophagram who underwent a laparoscopic sleeve gastrectomy and developed an esophageal adenocarcinoma five years later...
February 11, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28235596/outcomes-after-liquid-nitrogen-spray-cryotherapy-in-barrett-s-esophagus-associated-high-grade-dysplasia-and-intramucosal-adenocarcinoma-5-year-follow-up
#12
Fariha H Ramay, Qingping Cui, Bruce D Greenwald
BACKGROUND: Liquid nitrogen spray cryotherapy (LNSCT) has been shown to be a safe, well-tolerated, and effective therapy for Barrett's esophagus (BE)-associated high grade dysplasia (BE-HGD) and intramucosal adenocarcinoma (IMC). Long-term follow-up is lacking. AIMS: The authors' aim was to assess the efficacy, durability, and rate of neoplastic progression after LNSCT in BE-HGD/IMC at 3 and 5 years. METHODS: In this single-center, retrospective study drawn from a prospective database, patients with BE-HGD/IMC of any length treated with LNSCT were followed with surveillance endoscopy with biopsy for 3 to 5 years...
February 21, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28235595/an-international-multicenter-study-evaluating-the-clinical-efficacy-and-safety-of-per-oral-endoscopic-myotomy-in-octogenarians
#13
Yen-I Chen, Haruhiro Inoue, Michael Ujiki, Peter V Draganov, Paul Colavita, Francois Mion, John Romanelli, Philip Chiu, Valerio Balassone, Lava Patel, Ali Abbas, Dennis Yang, Christy Dunst, Mathieu Pioche, Sabine Roman, Jérôme Rivory, Thierry Ponchon, David Desilets, Roberta Maselli, Manabu Onimaru, Jun Nakamura, Yoshitaka Hata, Gulara Hajiyeva, Amr Ismail, Saowanee Ngamruengphong, Majidah Bukhari, Yamile Haito Chavez, Vivek Kumbhari, Alessandro Repici, Mouen A Khashab
BACKGROUND AND AIMS: Per-oral endoscopic myotomy (POEM) for achalasia is particularly appealing in the elderly due to its minimally invasiveness; however, data in patients age ≥ 80 years are scarce. The aim of this study was to assess the clinical outcome of POEM in octogenarians. METHODS: Multicenter retrospective study at 8 centers. Consecutive octogenarians with achalasia who underwent POEM between 2010 and 2016 were included. Rates of technical success (completion of myotomy), clinical response (Eckardt score ≤3), and adverse events (AEs) (severity graded as per American Society for Gastrointestinal Endoscopy [ASGE] lexicon) were assessed...
February 21, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28235133/a-case-of-diffuse-esophageal-leiomyomatosis-diagnosed-by-endoscopic-ultrasonography-and-endoscopic-mucosal-cutting-biopsy
#14
Akira Harada, Yuji Maehata, Motohiro Esaki
A 79-year-old man was referred to our hospital for scrutiny of multiple submucosal tumors (SMTs) in the esophagus. He had neither previous history nor suggestive symptoms of Alport syndrome. Esophagogastroduodenoscopy found multiple protrusions covered by normal mucosa in the middle esophagus (Fig. 1a). Endoscopic ultrasonography (EUS) revealed multiple hypoechoic lesions, up to 19mm in diameter, derived from the proper muscular layer. This article is protected by copyright. All rights reserved.
February 24, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28234134/a-defined-esophagectomy-perioperative-clinical-care-process-can-improve-outcomes-and-costs
#15
David T Cooke, Royce F Calhoun, Valerie Kuderer, Elizabeth A David
Esophagectomy (EG) is a high-risk therapy for esophageal cancer and end-stage benign disease. This study compares the results of EG before and after implementation of a perioperative clinical care process including a health provider education program (EP) and institutional uncomplicated postoperative clinical pathway (POP) for purpose quality improvement. This is a single institution retrospective cohort study. The EP was provided to critical care and telemetry unit nurses and the POP was imbedded in the electronic health record...
January 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28234131/a-multi-institutional-study-comparing-the-use-of-the-american-joint-committee-on-cancer-7th-edition-esophageal-versus-gastric-staging-system-for-gastroesophageal-junction-cancer-in-a-western-population
#16
Folashade A Adeshuko, Malcolm H Squires, George Poultsides, Timothy M Pawlik, Sharon M Weber, Carl Schmidt, Konstantinos Votanopoulos, Ryan C Fields, Shishir K Maithel, Kenneth Cardona
Controversy exists over the staging of gastroesophageal junction (GEJ) adenocarcinomas. The aim of our study was to assess the adequacy of the American Joint Committee on Cancer 7th edition esophageal (E7) and gastric (G7) staging systems for GEJ tumors in a western population. All patients with GEJ adenocarcinoma who underwent curative resection from 2000 to 2012 were identified from the United States Gastric Cancer Collaborative database and assessed according to the E7 and G7 systems. Fifty-one patients were identified...
January 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28233441/long-term-risk-of-portal-hypertension-and-related-complications-in-children-treated-with-6-thioguanine-for-acute-lymphoblastic-leukemia-a-single-center-experience
#17
Nirmalya Roy Moulik, Mary M Taj
Long-term follow-up of 11 children with 6-thioguanine-induced hepatoportal toxicity is described. Features of persistent portal hypertension in eight patients after 9.7 ± 3.4 years (mean ± SD) of treatment were more common in late presenters. Splenomegaly, thrombocytopenia and altered hepatic echotexture were seen in six, eight and seven patients, respectively. One of the thrombocytopenic patients had heavy menstrual bleeding and pregnancy loss. Five of six patients who underwent upper gastrointestinal endoscopy had esophageal varices and four underwent banding...
February 24, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28233302/suppressor-of-cytokine-signaling-1-gene-therapy-induces-potent-antitumor-effect-in-patient-derived-esophageal-squamous-cell-carcinoma-xenograft-mice
#18
Takahito Sugase, Tsuyoshi Takahashi, Satoshi Serada, Rie Nakatsuka, Minoru Fujimoto, Tomoharu Ohkawara, Hisashi Hara, Takahiko Nishigaki, Koji Tanaka, Yasuhiro Miyazaki, Tomoki Makino, Yukinori Kurokawa, Makoto Yamasaki, Kiyokazu Nakajima, Shuji Takiguchi, Tadamitsu Kishimoto, Masaki Mori, Yuichiro Doki, Tetsuji Naka
Chronic inflammation is involved in cancer growth in esophageal squamous cell carcinoma (ESCC), which is a highly refractory cancer with poor prognosis. This study investigated the antitumor effect and mechanisms of SOCS1 gene therapy for ESCC. Patients with ESCC showed epigenetics silencing of SOCS1 gene by methylation in the CpG islands. We infected ten ESCC cells with an adenovirus-expressing SOCS1 (AdSOCS1) to examine the antitumor effect and mechanism of SOCS1 overexpression. SOCS1 overexpression markedly decreased the proliferation of all ESCC cell lines and induced apoptosis...
February 24, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28233274/the-safety-of-appropriate-use-of-over-the-counter-proton-pump-inhibitors-an-evidence-based-review-and-delphi-consensus
#19
REVIEW
David A Johnson, Philip O Katz, David Armstrong, Henry Cohen, Brendan C Delaney, Colin W Howden, Peter Katelaris, Radu I Tutuian, Donald O Castell
The availability of over-the-counter (OTC) proton pump inhibitors (PPIs) for the short-term (2 weeks) management of frequent heartburn (≥2 days/week) has increased markedly, yet evidence-based recommendations have not been developed. A panel of nine international experts in gastroesophageal reflux disease developed consensus statements regarding the risks and benefits of OTC PPIs using a modified Delphi process. Consensus (based on ≥80% approval) was reached through multiple rounds of remote voting and a final round of live voting...
February 23, 2017: Drugs
https://www.readbyqxmd.com/read/28233093/systematic-review-and-meta-analysis-of-controlled-and-prospective-cohort-efficacy-studies-of-endoscopic-radiofrequency-for-treatment-of-gastroesophageal-reflux-disease
#20
Ronnie Fass, Frederick Cahn, Dennis J Scotti, David A Gregory
BACKGROUND: The endoscopic radiofrequency procedure (Stretta) has been used for more than a decade to treat patients with gastroesophageal reflux disease (GERD). However, the efficacy of the procedure in improving objective and subjective clinical endpoints needs to be further established. AIM: To determine the efficacy of the Stretta procedure in treating patients with GERD, using a systematic review and meta-analysis of controlled and cohort studies. METHODS: We conducted a systematic search of the PubMed and Cochrane databases for English language clinical studies of the Stretta procedure, published from inception until May 2016...
February 23, 2017: Surgical Endoscopy
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