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https://www.readbyqxmd.com/read/28345457/special-at-rich-sequence-binding-protein-1-promotes-tumor-growth-and-metastasis-of-esophageal-squamous-cell-carcinoma
#1
Jun Ma, Kaiming Wu, Zhenxian Zhao, Rong Miao, Zhe Xu
Esophageal squamous cell carcinoma is one of the most aggressive malignancies worldwide. Special AT-rich sequence binding protein 1 is a nuclear matrix attachment region binding protein which participates in higher order chromatin organization and tissue-specific gene expression. However, the role of special AT-rich sequence binding protein 1 in esophageal squamous cell carcinoma remains unknown. In this study, western blot and quantitative real-time polymerase chain reaction analysis were performed to identify differentially expressed special AT-rich sequence binding protein 1 in a series of esophageal squamous cell carcinoma tissue samples...
March 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28345328/esophageal-cancer-and-associated-factors-among-uzbek-turkmen-and-other-ethnic-groups-in-the-northern-part-of-afghanistan
#2
Mohammad Hassan Hamrah, Mohammad Shoaib Hamrah, Mitsuro Kanda, Junichi Sakamoto, Mohammad Hussain Hamrah, Asif Hami, Ahmad Edris Hamrah, Ahmad Elias Dahi, Mohammad Hashem Hamrah
Background: A high incidence rate of esophageal cancer has been observed in the Northern part of Afghanistan, particularly among those of Uzbek-Turkmen ethnicity. However, there is a paucity of published data from which to compare the prevalence of environmental risk factors for esophageal cancer between Uzbek-Turkmen and other ethnic groups. Thus, we investigated the prevalence of environmental risk factors associated with esophageal cancer in the Northern part of Afghanistan, focusing on ethnicity differences...
February 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28344746/cpg-island-methylator-phenotype-in-adenocarcinomas-from-the-digestive-tract-methods-conclusions-and-controversies
#3
EDITORIAL
Francisco Sánchez-Vega, Valer Gotea, Yun-Ching Chen, Laura Elnitski
Over the last two decades, cancer-related alterations in DNA methylation that regulate transcription have been reported for a variety of tumors of the gastrointestinal tract. Due to its relevance for translational research, great emphasis has been placed on the analysis and molecular characterization of the CpG island methylator phenotype (CIMP), defined as widespread hypermethylation of CpG islands in clinically distinct subsets of cancer patients. Here, we present an overview of previous work in this field and also explore some open questions using cross-platform data for esophageal, gastric, and colorectal adenocarcinomas from The Cancer Genome Atlas...
March 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28344602/safety-and-outcome-of-external-beam-radiation-and-neutron-brachytherapy-in-elderly-patients-with-esophageal-squamous-cell-cancer
#4
Tao Li, Wei Zhang, Jiahua Lv, Huiming Liu, Qifeng Wang, Xitang Jia, Bo Liu, Jinyi Lang
PURPOSE: The aim of this study was to retrospectively observe and analyze the long-term treatment outcomes of 191 elderly patients with esophageal squamous cell cancer (ESCC) who were treated with californium-252 ((252)Cf) neutron brachytherapy (NBT) in combination with external beam radiotherapy (EBRT). MATERIAL AND METHODS: From January 2002 to November 2012, 191 patients with ESCC underwent NBT in combination with EBRT. The total radiation dose to the reference point via NBT was 8-25 Gy-eq in two to five fractions with one fraction per week...
February 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28344601/high-dose-rate-intraluminal-brachytherapy-prior-to-external-radiochemotherapy-in-locally-advanced-esophageal-cancer-preliminary-results
#5
Afsaneh Maddah Safaei, Reza Ghalehtaki, Nezhat Khanjani, Borna Farazmand, Mohammad Babaei, Ebrahim Esmati
PURPOSE: Dysphagia is a common initial presentation in locally advanced esophageal cancer and negatively impacts patient quality of life and treatment compliance. To induce fast relief of dysphagia in patients with potentially operable esophageal cancer high-dose-rate (HDR) brachytherapy was applied prior to definitive radiochemotherapy. MATERIAL AND METHODS: In this single arm phase II clinical trial between 2013 to 2014 twenty patients with locally advanced esophageal cancer (17 squamous cell and 3 adenocarcinoma) were treated with upfront 10 Gy HDR brachytherapy, followed by 50...
February 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28344046/long-term-outcomes-of-induction-carboplatin-and-gemcitabine-followed-by-concurrent-radiotherapy-with-low-dose-paclitaxel-and-gemcitabine-for-stage-iii-non-small-cell-lung%C3%A2-cancer
#6
Catherine Guilbault, Aurelie Garant, Sergio Faria, Scott Owen, Linda Ofiara, Marie Duclos, Vera Hirsh, Neil Kopek
BACKGROUND: Standard treatment for unresectable stage III non-small-cell lung cancer (NSCLC) is concurrent chemo-radiation (CRT). A regimen of induction carboplatin and gemcitabine followed by CRT was developed at the McGill University Health Centre to prevent delays in treatment initiation. We report the long-term outcomes with this regimen based on a pooled analysis of both protocol patients from a phase II study and nonprotocol patients. METHODS AND MATERIALS: Outcomes and toxicity data were retrieved for 142 patients with stage III NSCLC: 43 patients treated on protocol between January 2003 and November 2004, and 101 patients treated off-protocol between December 2004 and August 2013...
March 1, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28343837/gastrointestinal-cancers-screening-and-early-detection
#7
REVIEW
Joyce P Griffin-Sobel
OBJECTIVE: To present an overview of current practices in the screening and early detection of gastrointestinal cancers. DATA SOURCES: Literature reviews. CONCLUSION: Screening for gastrointestinal cancers is less than desirable, particularly in underserved populations. There are inadequate methods of screening for early detection of esophageal and gastric cancers. IMPLICATIONS FOR NURSING PRACTICE: Education of patients is needed to reinforce the importance of screening for gastrointestinal cancers...
March 23, 2017: Seminars in Oncology Nursing
https://www.readbyqxmd.com/read/28343653/swallow-induced-syncope-and-carotid-sinus-hypersensitivity-coincident-or-associated-conditions
#8
Eed Abu Zaid, Moti Haim, Hilmi Alnsasra, Yuval Konstantino
Swallow induced syncope is a rare clinical condition which is thought to result from an abnormal vagal reflex leading to bradycardia and cerebral hypoperfusion. It mostly occurs in patients with organic or functional disorders of the esophagus, and often requires permanent pacemaker implantation, along with treatment of the underlying esophageal pathology. In the following case, we report of a 71-year-old male with achalasia post per oral endoscopic myectomy, who presented with syncope and documented AV-block while eating solid food...
March 14, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28343609/very-late-onset-dabigatran-induced-esophageal-injury
#9
Ko Fujikawa, Nobuhiro Takasugi, Tadao Goto, Shinya Minatoguchi
An 87-year-old man with persistent atrial fibrillation experienced heartburn and dysphagia at 2 years 9 months after initiation of dabigatran. An esophagogastroduodenoscopy demonstrated multiple longitudinal white plaques with ulcers in the narrowed midesophagus compressed between the left atrium and the tortuous aorta. We speculate that the esophageal stenosis contributed to stasis of dabigatran within the esophagus, resulting in prolonged mucosal contact with the caustic contents of the drug. Progressive enlargement of the left atrium may have led to the late onset of the potentially serious complication...
April 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28343226/the-effect-of-ineffective-esophageal-motility-on-gastroesophageal-reflux-disease
#10
Shingo Kasamatsu, Tomoaki Matsumura, Yuki Ohta, Shinsaku Hamanaka, Hideaki Ishigami, Takashi Taida, Kenichiro Okimoto, Keiko Saito, Daisuke Maruoka, Tomoo Nakagawa, Tatsuro Katsuno, Mai Fujie, Atsuko Kikuchi, Makoto Arai
BACKGROUND/AIMS: Ineffective esophageal motility (IEM) is the most common gastrointestinal motility disorder. Studies have reported that IEM is related to gastroesophageal reflux disease (GERD). However, the relationship between IEM and GERD remains uncertain. This study aims to clarify this relationship retrospectively. METHODS: We analyzed 195 subjects who underwent high-resolution manometry between January 2011 and September 2016. Of these subjects, 72 had normal esophageal motility (NEM) and 26 had IEM...
March 25, 2017: Digestion
https://www.readbyqxmd.com/read/28343076/repression-of-dok7-mediated-by-dnmt3a-promotes-the-proliferation-and-invasion-of-kyse410-and-te-12-escc-cells
#11
Shou-Mei Yang, Su-Yi Li, Hao-Bin Yu, Jie-Ru Li, Lei-Lei Sun
Increasing evidence shows that aberrant epigenetic regulation of tumor suppressor genes is a contributing factor to their altered expression in esophageal squamous cell carcinoma (ESCC). In the current study, we investigate the role of DOK7 in ESCC cells. We found that enforced expression of DOK7 inhibited the proliferation and invasion of ESCC cells. We also found that treatment of ESCC cells with the DNA methylation inhibitor, 5-aza-2-deoxycytidine (5-azadC), induced the demethylation of DOK7 in promoter and DOK7 expression...
March 23, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28342955/white-paper-aga-eosinophilic-esophagitis
#12
Ikuo Hirano, Stuart Spechler, Glenn Furuta, Evan S Dellon
No abstract text is available yet for this article.
March 22, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28342951/a-model-to-identify-individuals-at-high-risk-for-esophageal-squamous-cell-carcinoma-and-precancerous-lesions-in-regions-of-high-prevalence-in-china
#13
Mengfei Liu, Zhen Liu, Hong Cai, Chuanhai Guo, Xiang Li, Chaoting Zhang, Hui Wang, Dong Hang, Fangfang Liu, Qiuju Deng, Xin Yang, Wenqing Yuan, Yaqi Pan, Jingjing Li, Chanyuan Zhang, Na Shen, Zhonghu He, Yang Ke
BACKGROUND & AIMS: We aimed to develop a population-based model to identify individuals at high-risk for esophageal squamous cell carcinoma (ESCC) in regions of China with a high prevalence of this cancer. METHODS: We collected findings from 15,073 permanent residents (45-69 years old) of 334 randomly selected villages in Hua County, Henan Province, China who underwent endoscopic screening (with iodine staining) for ESCC from January 2012 through September 2015...
March 22, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28342894/endoscopic-treatment-of-cervical-esophageal-transluminal-bridge
#14
Sinkeet Rankeeti, Michael Mwachiro, Mark Topazian, Stephen Burgert
No abstract text is available yet for this article.
March 22, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28342863/disturbed-tryptophan-metabolism-correlating-to-progression-and-metastasis-of-esophageal-squamous-cell-carcinoma
#15
Jing Cheng, Hai Jin, Xiaobei Hou, Jie Lv, Xianfu Gao, Guangyong Zheng
Esophageal squamous cell carcinoma (ESCC) is one of the most frequent malignancies worldwide. Lymph node metastasis is the leading cause of death in ESCC patients. To identify early diagnostic and prognostic biomarkers of ESCC and elucidate underlying pathogenesis of the disease, a targeted metabolomics strategy based on liquid chromatography combined with tandem mass spectrometry was applied to explore tryptophan metabolism between ESCC patients, metastatic ESCC patients (mESCC), and healthy controls. Statistical analysis on metabolite expression abundance and compound concentration ratio was conducted to discriminate patients from healthy controls...
March 23, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28342128/efficacy-and-safety-of-endoscopic-submucosal-dissection-in-elderly-patients-with-esophageal-squamous-cell-carcinoma
#16
Byeong Geun Song, Yang Won Min, Jun Haeng Lee, Hyuk Lee, Byung-Hoon Min, Poong-Lyul Rhee, Jae J Kim
BACKGROUND: Endoscopic submucosal dissection (ESD) has been widely applied in superficial esophageal squamous cell carcinoma (SESCC) as a minimally invasive treatment, which has advantages over surgery, especially in the elderly who have high risk of surgery. This study elucidated the efficacy and safety of ESD for SESCC in the elderly. METHODS: Between April 2007 and June 2016, a total of 176 patients with SESCC treated with ESD were analyzed. Clinical outcomes including En bloc, complete, and curative resection rates, procedure-related complication rates, and cumulative recurrence rates were compared between the elderly (n = 46, ≥70 years of age) and the non-elderly groups (n = 130, <70 years of age)...
March 24, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28341911/nutlin-3-an-antagonist-of-mdm2-enhances-the-radiosensitivity-of-esophageal-squamous-cancer-with-wild-type-p53
#17
Tianli He, Jiayou Guo, Hongmei Song, Hongcheng Zhu, Xiaoke Di, Hua Min, Yuandong Wang, Guangzong Chen, Wangshu Dai, Jianhua Ma, Xinchen Sun, Jianxin Ma
Murine double minute 2 (MDM2) negatively regulates the activity of the p53 protein and plays a vital role in cell cycle arrest, apoptosis, and senescence mediated by p53. Nutlin-3, an antagonist of MDM2, is frequently used in anti-cancer studies. In many human tumors, nutlin-3 stabilizes p53 status and enhances p53 expression in cells with wild-type p53. However, the effect of nutlin-3 combined with radiotherapy on esophageal squamous cancer (ESCC) has not been reported. In this study, we examined whether nutlin-3 increases the radiosensitivity of ESCC in vitro and in vivo...
March 24, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28341225/improved-outcomes-with-modern-lung-sparing-trimodality-therapy-in-patients-with-malignant-pleural-mesothelioma
#18
Fauzia Shaikh, Marjorie G Zauderer, Donata von Reibnitz, Abraham J Wu, Ellen D Yorke, Amanda Foster, Weiji Shi, Zhigang Zhang, Prasad S Adusumilli, Kenneth E Rosenzweig, Lee M Krug, Valerie W Rusch, Andreas Rimner
INTRODUCTION: Higher target conformity and better sparing of organs at risk with modern radiotherapy (RT) may result in higher tumor control and less toxicities. In this study, we compare our institutional multimodality therapy experience of adjuvant chemotherapy and hemithoracic intensity-modulated pleural RT (IMPRINT) to previously used adjuvant conventional RT (CONV) in patients with malignant pleural mesothelioma (MPM) treated with lung-sparing pleurectomy/decortication (P/D). METHODS: We analyzed 209 patients who underwent P/D and adjuvant RT (n[CONV]=131, n[IMPRINT]=78) for MPM between 1974 and 2015...
March 21, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28340493/conservative-treatment-with-octreotide-to-provide-early-recovery-of-children-with-esophageal-perforation
#19
Ramazan Karabulut, Zafer Turkyilmaz, Kaan Sonmez, Abdullah Can Basaklar
Background The effectiveness of nonoperative treatment of esophageal perforation (EP) in children with octreotide is highlighted. Methods Records of nine patients (seven boys and two girls with an average age of 5.83 ± 5.35 years) with EP were reviewed. Results EP developed in six patients during dilation of esophageal stenosis (five of six caused by caustic burns). In the other three patients, EP developed after nasogastric placement, after endotracheal intubation, and during endoscopy for foreign body...
March 24, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28339468/pbmda-a-novel-and-effective-path-based-computational-model-for-mirna-disease-association-prediction
#20
Zhu-Hong You, Zhi-An Huang, Zexuan Zhu, Gui-Ying Yan, Zheng-Wei Li, Zhenkun Wen, Xing Chen
In the recent few years, an increasing number of studies have shown that microRNAs (miRNAs) play critical roles in many fundamental and important biological processes. As one of pathogenetic factors, the molecular mechanisms underlying human complex diseases still have not been completely understood from the perspective of miRNA. Predicting potential miRNA-disease associations makes important contributions to understanding the pathogenesis of diseases, developing new drugs, and formulating individualized diagnosis and treatment for diverse human complex diseases...
March 24, 2017: PLoS Computational Biology
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