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https://www.readbyqxmd.com/read/29782593/-18-f-fdg-pet-ct-joint-assessment-of-early-therapeutic-response-in-rheumatoid-arthritis-patients-treated-with-rituximab
#1
Pacôme Fosse, Marie-Joelle Kaiser, Gauthier Namur, Dominique de Seny, Michel G Malaise, Roland Hustinx
Background: 18 F-FDG PET/CT has been proposed in the evaluation of the disease activity in rheumatoid arthritis (RA). The goals of this study were to evaluate the reproducibility of the technique, to compare metabolic parameters to clinical, biological and ultrasonographic parameters before and after treatment and to evaluate whether the early metabolic response was related to the outcome. 18 F- FDG PET/CT of the hands, wrists and knees was obtained in 15 patients with anti-TNFα refractory RA, at baseline and 16 weeks after treatment with rituximab...
2018: Eur J Hybrid Imaging
https://www.readbyqxmd.com/read/29781725/the-effects-of-an-expanded-cognitive-stimulation-therapy-model-on-the-improvement-of-cognitive-ability-of-elderly-with-mild-stage-dementia-living-in-a-community-a-randomized-waitlist-controlled-trial
#2
Daniel Kim-Wan Young, Petrus Yat-Nam Ng, Timothy Kwok, Florence Ho, Daphne Cheng, Vivan Mak, Andrew Lau
OBJECTIVE: This research study aims to evaluate the effectiveness of an expanded cognitive stimulation therapy (CST) model that combines a CST group and tai chi on improving the cognitive ability of community-dwelling Chinese elderly with mild stage dementia (EwMD). METHOD: A randomized waitlist controlled trial design was adopted in this study. The treatment group participated in a structured CST group followed by tai chi twice a week, with a total of 14 sessions throughout the study period...
May 21, 2018: Aging & Mental Health
https://www.readbyqxmd.com/read/29774655/ctc1-stn1-coordinates-g-and-c-strand-synthesis-to-regulate-telomere-length
#3
Peili Gu, Shuting Jia, Taylor Takasugi, Eric Smith, Jayakrishnan Nandakumar, Eric Hendrickson, Sandy Chang
Coats plus (CP) is a rare autosomal recessive disorder caused by mutations in CTC1, a component of the CST (CTC1, STN1, and TEN1) complex important for telomere length maintenance. The molecular basis of how CP mutations impact upon telomere length remains unclear. The CP CTC1L1142H mutation has been previously shown to disrupt telomere maintenance. In this study, we used CRISPR/Cas9 to engineer this mutation into both alleles of HCT116 and RPE cells to demonstrate that CTC1:STN1 interaction is required to repress telomerase activity...
May 17, 2018: Aging Cell
https://www.readbyqxmd.com/read/29774234/the-fission-yeast-stn1-ten1-complex-limits-telomerase-activity-via-its-sumo-interacting-motif-and-promotes-telomeres-replication
#4
Samah Matmati, Mélina Vaurs, José M Escandell, Laetitia Maestroni, Toru M Nakamura, Miguel G Ferreira, Vincent Géli, Stéphane Coulon
Mammalian CST (CTC1-STN1-TEN1) complex fulfills numerous functions including rescue of the stalled replication forks and termination of telomerase action. In fission yeast lacking the CTC1 ortholog, the Stn1-Ten1 complex restricts telomerase action via its sumoylation-mediated interaction with Tpz1TPP1 . We identify a small ubiquitin-like modifier (SUMO)-interacting motif (SIM) in the carboxyl-terminal part of Stn1 and show that this domain is crucial for SUMO and Tpz1-SUMO interactions. Point mutations in the SIM (Stn1-226) lead to telomere elongation, impair Stn1-Ten1 recruitment to telomeres, and enhance telomerase binding, revealing that Stn1 SIM domain contributes to the inhibition of telomerase activity at chromosome ends...
May 2018: Science Advances
https://www.readbyqxmd.com/read/29768208/the-cst-complex-mediates-end-protection-at-double-strand-breaks-and-promotes-parp-inhibitor-sensitivity-in-brca1-deficient-cells
#5
Marco Barazas, Stefano Annunziato, Stephen J Pettitt, Inge de Krijger, Hind Ghezraoui, Stefan J Roobol, Catrin Lutz, Jessica Frankum, Fei Fei Song, Rachel Brough, Bastiaan Evers, Ewa Gogola, Jinhyuk Bhin, Marieke van de Ven, Dik C van Gent, Jacqueline J L Jacobs, Ross Chapman, Christopher J Lord, Jos Jonkers, Sven Rottenberg
Selective elimination of BRCA1-deficient cells by inhibitors of poly(ADP-ribose) polymerase (PARP) is a prime example of the concept of synthetic lethality in cancer therapy. This interaction is counteracted by the restoration of BRCA1-independent homologous recombination through loss of factors such as 53BP1, RIF1, and REV7/MAD2L2, which inhibit end resection of DNA double-strand breaks (DSBs). To identify additional factors involved in this process, we performed CRISPR/SpCas9-based loss-of-function screens and selected for factors that confer PARP inhibitor (PARPi) resistance in BRCA1-deficient cells...
May 15, 2018: Cell Reports
https://www.readbyqxmd.com/read/29766933/corticospinal-tract-changes-in-acute-brainstem-ischemic-stroke-patients-a-diffusion-kurtosis-imaging-study
#6
Huiyou Chen, Liang Jiang, Hong Zhang, Ying-Dong Zhang, Wen Geng, Yuan Feng, Qian Chen, Yu-Chen Chen, Xindao Yin
Purpose: The present study aimed to investigate the corticospinal tract (CST) changes in patients with brainstem ischemic stroke by using the diffusion kurtosis imaging (DKI) approach.. Materials and Methods: Twenty-one patients with brainstem stroke and 21 group-matched healthy controls underwent brain DKI with 3.0 T magnetic resonance imaging (MRI). The DKI was obtained by using three b values of 0, 1,000, 2,000 s/mm2 with 15 diffusion directions. Regions of interest (ROIs) were placed at four levels: the pons, posterior limb of the internal capsule (PLIC), corona radiata, and precentral gyrus...
May 2018: Neurology India
https://www.readbyqxmd.com/read/29752001/efficacy-of-ranibizumab-in-eyes-with-diabetic-macular-edema-and-macular-nonperfusion-in-ride-and-rise
#7
Rahul K Reddy, Dante J Pieramici, Shamika Gune, Avanti Ghanekar, Na Lu, Carlos Quezada-Ruiz, Caroline R Baumal
PURPOSE: To determine whether there are baseline characteristics that distinguish patients with diabetic macular edema (DME) with coexisting macular nonperfusion (MNP) at baseline and assess these patients' potential to achieve favorable visual acuity (VA), anatomic, and diabetic retinopathy (DR) outcomes over 24 months. DESIGN: Post hoc analysis of RIDE/RISE, 2 phase 3, parallel, randomized, multicenter, double-masked trials (ClinicalTrials.gov: NCT00473382; NCT00473330)...
May 8, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29736847/changes-in-sensorimotor-related-thalamic-diffusion-properties-and-cerebrospinal-fluid-hydrodynamics-predict-gait-responses-to-tap-test-in-idiopathic-normal-pressure-hydrocephalus
#8
Ping-Huei Tsai, Yung-Chieh Chen, Shih-Wei Chiang, Teng-Yi Huang, Ming-Chung Chou, Hua-Shan Liu, Hsiao-Wen Chung, Giia-Sheun Peng, Hsin-I Ma, Hung-Wen Kao, Cheng-Yu Chen
OBJECTIVES: To compare diffusion tensor (DT)-derived indices from the thalamic nuclei and cerebrospinal fluid (CSF) hydrodynamic parameters for the prediction of gait responsiveness to the CSF tap test in early iNPH patients. METHODS: In this study, 22 patients with iNPH and 16 normal controls were enrolled with the approval of an institutional review board. DT imaging and phase-contrast magnetic resonance imaging were performed in patients and controls to determine DT-related indices of the sensorimotor-related thalamic nuclei and CSF hydrodynamics...
May 7, 2018: European Radiology
https://www.readbyqxmd.com/read/29734997/consumer-sleep-technology-an-american-academy-of-sleep-medicine-position-statement
#9
Seema Khosla, Maryann C Deak, Dominic Gault, Cathy A Goldstein, Dennis Hwang, Younghoon Kwon, Daniel O'Hearn, Sharon Schutte-Rodin, Michael Yurcheshen, Ilene M Rosen, Douglas B Kirsch, Ronald D Chervin, Kelly A Carden, Kannan Ramar, R Nisha Aurora, David A Kristo, Raman K Malhotra, Jennifer L Martin, Eric J Olson, Carol L Rosen, James A Rowley
Consumer sleep technologies (CSTs) are widespread applications and devices that purport to measure and even improve sleep. Sleep clinicians may frequently encounter CST in practice and, despite lack of validation against gold standard polysomnography, familiarity with these devices has become a patient expectation. This American Academy of Sleep Medicine position statement details the disadvantages and potential benefits of CSTs and provides guidance when approaching patient-generated health data from CSTs in a clinical setting...
May 15, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29733992/neuronavigation-guided-corticospinal-tract-mapping-in-brainstem-tumor-surgery-better-preservation-of-motor-function
#10
Zhibao Li, Mingran Wang, Liwei Zhang, Xing Fan, Xiaorong Tao, Lei Qi, Miao Ling, Xiong Xiao, Yuliang Wu, Dongze Guo, Hui Qiao
BACKGROUND: A new method in brainstem surgery, neuronavigation (NN)-guided corticospinal tract (CST) mapping, was used in a retrospective study of patients undergoing brainstem tumor surgery. METHODS: We studied 40 patients with a brainstem tumor who were enrolled in this study. Patients whose worst preoperative muscle strength of the four limbs was greater than three levels from normal on the Lovett scale were divided into two groups: a treatment group of 21 patients that included NN-guided CST mapping and routine intraoperative neurophysiology monitoring (IONM), and a control group of 19 patients that included routine NN and routine IONM...
May 4, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29730892/activation-of-p70s6-kinase-1-in-mesenchymal-stem-cells-is-essential-to-lung-tissue-repair
#11
Katsuyuki Takeda, Fangkun Ning, Joanne Domenico, Masakazu Okamoto, Shigeru Ashino, Sang-Ha Kim, Yi Yeong Jeong, Yoshiki Shiraishi, Naohiro Terada, Everett Rand Sutherland, Erwin W Gelfand
All-trans retinoic acid (ATRA) or mesenchymal stem cells (MSCs) have been shown to promote lung tissue regeneration in animal models of emphysema. However, the reparative effects of the combination of the two and the role of p70S6 kinase-1 (p70S6k1) activation in the repair process have not been defined. Twenty-one days after intratracheal instillation of porcine pancreatic elastase (PPE), MSC and/or 10 days of ATRA treatment was initiated. Thirty-two days later, static lung compliance (Cst), mean linear intercepts (MLIs), and alveolar surface area (S) were measured...
May 5, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29730822/shall-we-stay-or-shall-we-switch-continued-anti-vegf-therapy-versus-early-switch-to-dexamethasone-implant-in-refractory-diabetic-macular-edema
#12
Catharina Busch, Dinah Zur, Samantha Fraser-Bell, Inês Laíns, Ana Rita Santos, Marco Lupidi, Carlo Cagini, Pierre-Henry Gabrielle, Aude Couturier, Valérie Mané-Tauty, Ermete Giancipoli, Giuseppe D'Amico Ricci, Zafer Cebeci, Patricio J Rodríguez-Valdés, Voraporn Chaikitmongkol, Atchara Amphornphruet, Isaac Hindi, Kushal Agrawal, Jay Chhablani, Anat Loewenstein, Matias Iglicki, Matus Rehak
AIMS: To compare functional and anatomical outcomes of continued anti-vascular endothelial growth factor (VEGF) therapy versus dexamethasone (DEX) implant in eyes with refractory diabetic macular edema (DME) after three initial anti-VEGF injections in a real-world setting. METHODS: To be included in this retrospective multicenter, case-control study, eyes were required: (1) to present with early refractory DME, as defined by visual acuity (VA) gain ≤ 5 letters or reduction in central subfield thickness (CST) ≤ 20%, after a loading phase of anti-VEGF therapy (three monthly injections) and (2) to treat further with (a) anti-VEGF therapy or (b) DEX implant...
May 5, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29729248/stimulation-dependent-remodeling-of-the-corticospinal-tract-requires-reactivation-of-growth-promoting-developmental-signaling-pathways
#13
Neela Zareen, Shahid Dodson, Kristine Armada, Rahma Awad, Nadia Sultana, Erina Hara, Heather Alexander, John H Martin
The corticospinal tract (CST) can become damaged after spinal cord injury or stroke, resulting in weakness or paralysis. Repair of the damaged CST is limited because mature CST axons fail to regenerate, which is partly because the intrinsic axon growth capacity is downregulated in maturity. Whereas CST axons sprout after injury, this is insufficient to recover lost functions. Chronic motor cortex (MCX) electrical stimulation is a neuromodulatory strategy to promote CST axon sprouting, leading to functional recovery after CST lesion...
May 2, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29725708/outcomes-of-stress-urinary-incontinence-in-women-undergoing-tot-versus-burch-colposuspension-with-abdominal-sacrocolpopexy
#14
George Lazarou, Evelyn Minis, Bogdan Grigorescu
INTRODUCTION AND HYPOTHESIS: To compare postoperative rates of stress urinary incontinence (SUI) in patients with pelvic organ prolapse and SUI undergoing abdominal sacrocolpopexy (ASC) with Burch colposuspension or a transobturator tape (TOT) sling. METHODS: In this retrospective cohort study, medical records of 117 patients who underwent ASC with Burch (n = 60) or TOT (n = 57) between 2008 and 2010 at NYU Winthrop Hospital were assessed. Preoperative evaluation included history, physical examination, cough stress test (CST), and multichannel urodynamic studies (MUDS)...
May 3, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29719853/reconstruction-of-white-matter-fibre-tracts-using-diffusion-kurtosis-tensor-imaging-at-1-5t-pre-surgical-planning-in-patients-with-gliomas
#15
Joao Leote, Rita G Nunes, Luis Cerqueira, Ricardo Loução, Hugo A Ferreira
Tractography studies for pre-surgical planning of primary brain tumors is typically done using diffusion tensor imaging (DTI), which cannot resolve crossing, kissing or highly angulated fibres. Tractography based on the estimation of the diffusion kurtosis (DK) tensor was recently demonstrated to enable tackling these limitations. However, its use in the clinical context at low 1.5T field has not yet been reported. Purpose: To evaluate if the estimation of whole-brain tractography using the DK tensor is feasible for pre-surgical investigation of patients with brain tumors at 1...
2018: European Journal of Radiology Open
https://www.readbyqxmd.com/read/29717527/cultural-adaptation-of-cognitive-stimulation-therapy-cst-for-chinese-people-with-dementia-multicentre-pilot-study
#16
Gloria H Y Wong, Olive P L Yek, Anna Y Zhang, Terry Y S Lum, Aimee Spector
OBJECTIVE: Ageing of the Chinese population will drive a continued surge in dementia prevalence. Empirically tested non-pharmacological interventions developed in western cultures may be implemented in Chinese. Cognitive Stimulation Therapy (CST) that originated in the UK has proven benefits on cognition and quality of life in people with dementia. We investigated the feasibility and cultural appropriateness of CST in Hong Kong Chinese (CST-HK). METHODS: Mixed methods research was conducted following the formative method for adapting psychotherapy...
June 2018: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29716863/analysis-of-the-main-constituents-of-changshu-tablet-and-its-spasmolysis-effect-against-contraction-induced-by-acetylcholine-in-the-rat-isolated-intestinal-smooth-muscle
#17
Ying An, Guangming Song, Dailin Liu, Tianyi Mao, Yanmin Zhao, Wenli Xie
The Changshu tablet (CST), one kind of Chinese patent medicine with astringent to the intestine and relieving diarrhea, was made by the root of Rose odorata Sweet var. gigantean (Coll.et Hemsl.) Rehd.et Wils. Although CST has a long history of clinical application, but the research of its chemical composition is less. So the objective of this study was to investigate the main constituents and preliminarily research its effect of the contraction of isolated intestine in vitro. The contents of total polyphenols (126...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29713221/altered-white-matter-integrity-in-human-immunodeficiency-virus-associated-neurocognitive-disorder-a-tract-based-spatial-statistics-study
#18
Se Won Oh, Na-Young Shin, Jun Yong Choi, Seung-Koo Lee, Mi Rim Bang
Objective: Human immunodeficiency virus (HIV) infection has been known to damage the microstructural integrity of white matter (WM). However, only a few studies have assessed the brain regions in HIV-associated neurocognitive disorders (HAND) with diffusion tensor imaging (DTI). Therefore, we sought to compare the DTI data between HIV patients with and without HAND using tract-based spatial statistics (TBSS). Materials and Methods: Twenty-two HIV-infected patients (10 with HAND and 12 without HAND) and 11 healthy controls (HC) were enrolled in this study...
May 2018: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/29712564/effectiveness-of-a-new-model-of-primary-care-management-on-knee-pain-and-function-in-patients-with-knee-osteoarthritis-protocol-for-the-partner-study
#19
David J Hunter, Rana S Hinman, Jocelyn L Bowden, Thorlene Egerton, Andrew M Briggs, Stephen J Bunker, Jessica Kasza, Andrew B Forbes, Simon D French, Marie Pirotta, Deborah J Schofield, Nicholas A Zwar, Kim L Bennell
BACKGROUND: To increase the uptake of key clinical recommendations for non-surgical management of knee osteoarthritis (OA) and improve patient outcomes, we developed a new model of service delivery (PARTNER model) and an intervention to implement the model in the Australian primary care setting. We will evaluate the effectiveness and cost-effectiveness of this model compared to usual general practice care. METHODS: We will conduct a mixed-methods study, including a two-arm, cluster randomised controlled trial, with quantitative, qualitative and economic evaluations...
April 30, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29712426/hydrogen-sulfide-sensing-through-reactive-sulfur-species-rss-and-nitroxyl-hno-in-enterococcus-faecalis
#20
Jiangchuan Shen, Brenna J C Walsh, Ana Lidia Flores-Mireles, Hui Peng, Yifan Zhang, Yixiang Zhang, Jonathan C Trinidad, Scott J Hultgren, David P Giedroc
Recent studies of hydrogen sulfide (H2S) signaling implicate low molecular weight (LMW) thiol persulfides and other reactive sulfur species (RSS) as signaling effectors. Here, we show that a CstR protein from the human pathogen Enterococcus faecalis ( E. faecalis), previously identified in Staphylococcus aureus ( S. aureus), is an RSS-sensing repressor that transcriptionally regulates a cst-like operon in response to both exogenous sulfide stress and Angeli's salt, a precursor of nitroxyl (HNO). E. faecalis CstR reacts with coenzyme A persulfide (CoASSH) to form interprotomer disulfide and trisulfide bridges between C32 and C61' which negatively regulate DNA binding to a consensus CstR DNA operator...
April 30, 2018: ACS Chemical Biology
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