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https://www.readbyqxmd.com/read/28429407/spinal-cord-injury-induces-widespread-chronic-changes-in-cerebral-white-matter
#1
Tero Ilvesmäki, Eerika Koskinen, Antti Brander, Teemu Luoto, Juha Öhman, Hannu Eskola
Traumatic spinal cord injuries (SCIs) lead to axonal damage at the trauma site, as well as disconnections within the central nervous system. While the exact mechanisms of the long-term pathophysiological consequences of SCIs are not fully understood, it is known that neuronal damage and degeneration are not limited to the direct proximity of the trauma. Instead, the effects can be detected even in the cerebrum. We examined SCI-induced chronic brain changes with a case-control design using 32 patients and 70 control subjects...
April 21, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28427370/child-sex-tourism-prevalence-of-and-risk-factors-for-its-use-in-a-german-community-sample
#2
Thula Koops, Daniel Turner, Janina Neutze, Peer Briken
BACKGROUND: To investigate the prevalence of child sex tourism (CST) in a large German community sample, and to compare those who made use of CST with other child sexual abusers regarding established characteristics and risk factors for child sexual abuse. METHODS: Adult German men were recruited through a German market research panel and questioned by means of an anonymous online survey. Group assignment was accomplished based on information on previous sexual contacts with children and previous use of CST...
April 20, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28427070/practical-lessons-from-protocol-t-for-the-management-of-diabetic-macular-edema
#3
Lekha Mukkamala, Neelakshi Bhagat, Marco Zarbin
PURPOSE: To review the results of Diabetic Retinopathy Clinical Research Network Protocol T, as applied to clinical practice. METHODS: Review of major publications reporting the results of Protocol T, a randomized single-masked (in year-1 only), multicenter clinical trial comparing aflibercept, bevacizumab, and ranibizumab as treatment option for center-involving diabetic macular edema (DME). The main outcome measures were change in visual acuity (VA), central subfield thickness (CST) on optical coherence tomography, cost effectiveness, burden of care, and safety...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28427057/long-term-anatomical-and-functional-outcomes-in-patients-with-ischemic-central-retinal-vein-occlusion-treated-with-anti-vascular-endothelial-growth-factor-agents
#4
Irini Chatziralli, George Theodossiadis, Efstratios Parikakis, Panagiotis G Mitropoulos, Panagiotis Theodossiadis
PURPOSE: To evaluate the anatomical and functional outcomes in patients with ischemic central retinal vein occlusion (CRVO) treated with intravitreal anti-vascular endothelial growth factor (VEGF) agents. METHODS: This retrospective study included 15 treatment-naive patients with ischemic CRVO and macular edema who were treated with intravitreal ranibizumab or aflibercept. The main outcomes were the evolution of retinal ischemia over time, as well as the change in best corrected visual acuity (BCVA) and in central subfield thickness (CST) at month 24...
April 21, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28422895/diffusion-tensor-tractography-for-detection-of-concomitant-traumatic-brain-injury-in-patients-with-traumatic-spinal-cord-injury
#5
Sung Ho Jang, Sang Ho Ahn, Yun Woo Cho, Ji Woon Lim, Ik Tae Cho
OBJECTIVES: We investigated concomitant traumatic brain injury in patients with traumatic spinal cord injury (TSCI) who had head trauma history, using diffusion tensor tractography (DTT). DESIGN: Retrospective survey. PARTICIPANTS: We recruited 14 consecutive patients with TSCI and coexisting head trauma history at the time of TSCI and 30 control subjects. METHODS: The corticospinal tract (CST), corticoreticulospinal tract (CRT), cingulum, and fornix were reconstructed using DTT, and DTT parameters (fractional anisotropy and fiber volume) and configuration were estimated...
January 18, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28409672/making-a-difference-a-study-of-cognitive-stimulation-therapy-cst-for-persons-with-dementia
#6
Daniel B Stewart, Marla Berg-Weger, Susan Tebb, Michele Sakamoto, Kristina Roselle, Laura Downing, Janice Lundy, Deborah Hayden
Affecting nearly 5.4 million older adults in the U.S. and 35.6 million individuals worldwide, dementia is one of the greatest public health crises of our time. As a result, helping professionals, clients, and care partners seek effective and affordable treatment. Developed in the United Kingdom by Spector and colleagues, Cognitive Stimulation Therapy (CST) is a non-pharmacologic psychosocial group intervention for persons with dementia. To expand upon and fill the gaps within existing research, the authors developed a descriptive study to assess the impact of CST on cognition, quality of life, and depression, among six CST groups (n = 40)...
April 14, 2017: Journal of Gerontological Social Work
https://www.readbyqxmd.com/read/28406325/akinetic-mutism-in-a-patient-with-mild-traumatic-brain-injury-a-diffusion-tensor-tractography-study
#7
Sung Ho Jang, Hyeok Gyu Kwon
OBJECTIVES: Akinetic mutism (AM) is characterized by a complete absence of spontaneous behaviour and speech. We report on a patient with AM associated with injury of the prefronto-caudate tract and prefronto-thalamic tract following mild traumatic brain injury (TBI), diffusion tensor tractography (DTT). CASE PRESENTATION: A 20-year-old man suffered from TBI resulting from a pedestrian car accident. Following the TBI, he developed abulia (decreased activity and speech) that worsened over approximately a year...
April 13, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28405409/effects-of-communication-skill-training-cst-based-on-spikes-for-insurance-covered-pharmacy-pharmacists-to-interact-with-simulated-cancer-patients
#8
Manako Hanya, Yoshitake Kanno, Junko Akasaki, Keiko Abe, Kazuhiko Fujisaki, Hiroyuki Kamei
BACKGROUND: With the development of pharmacotherapy and radiotherapy, cancer treatment is being shifted from surgical to outpatient services, consequently increasing insurance-covered pharmacies' frequency of dealing with cancer patients. As the psychology of these patients is complex, it is necessary for pharmacists to educate them in consideration of their cognitive/medical and psychosocial aspects. This study analyzed cancer patient management by pharmacists working in such pharmacies and their communication skills before and after communication skill training based on SPIKES, a six-step protocol for delivering bad news, to confirm the usefulness of such training...
2017: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/28404670/intravitreal-dexamethasone-implant-in-radiation-induced-macular-oedema
#9
Luisa Frizziero, Raffaele Parrozzani, Sara Trainiti, Elisabetta Pilotto, Giacomo Miglionico, Serena Pulze, Edoardo Midena
AIMS: To evaluate the efficacy and duration of activity of a single intravitreal dexamethasone implant in patients affected by radiation maculopathy. METHODS: Thirteen consecutive eyes of 13 patients affected by radiation maculopathy secondary to eye irradiation for a primary uveal melanoma (Iodine-125 brachytherapy) and treated with a single intravitreal 0.7 mg dexamethasone implant were retrospectively evaluated. Each patient underwent full ophthalmological examination, including fluorescein angiography and spectral domain optical coherence tomography (SD-OCT), even in en-face modality...
April 12, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28403837/effect-of-individualized-communication-skills-training-on-physicians-discussion-of-clinical-trials-in-oncology-results-from-a-randomized-controlled-trial
#10
Alexander Wuensch, Tanja Goelz, Gabriele Ihorst, Darcey D Terris, Hartmut Bertz, Juergen Bengel, Michael Wirsching, Kurt Fritzsche
BACKGROUND: Discussing randomized clinical trials (RCTs) with cancer patients is one of the most challenging communication tasks a physician faces. Only two prior Communication Skills Trainings (CSTs) focused on RCTs in oncology have been reported. Their results demonstrated the need for further improvement. We developed and evaluated an enhanced, individually-tailored CST focused on improving physicians' communication during discussions of RCTs. METHODS: The CST focused on personal learning goals derived from video pre-assessment that were addressed in a 1...
April 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28394195/composite-mri-measures-and-short-term-disability-in-patients-with-clinically-isolated-syndrome-suggestive-of-ms
#11
Giulia Bommarito, Alessandro Bellini, Matteo Pardini, Claudio Solaro, Luca Roccatagliata, Alice Laroni, Elisabetta Capello, Giovanni Luigi Mancardi, Antonio Uccelli, Matilde Inglese
BACKGROUND: The use of composite magnetic resonance imaging (MRI) measures has been suggested to better explain disability in patients with multiple sclerosis (MS). However, little is known about the utility of composite scores at the earliest stages of the disease. OBJECTIVE: To investigate whether, in patients with clinically isolated syndrome (CIS), a composite MRI measure, rather than the single metrics, would explain conversion to MS and would better correlate with disability at baseline and at 1 year of follow-up...
April 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28392595/the-principles-of-catholic-social-teaching-a-guide-for-decision-making-from-daily-clinical-encounters-to-national-policy-making
#12
Karen Shields Wright
Catholic social teaching (CST), a branch of moral theology, addresses contemporary issues within the political, economic, and cultural structures of society. The threefold cornerstone of CST contains the principles of human dignity, solidarity, and subsidiarity. It is the foundation on which to form our conscience in order to evaluate the framework of society and is the Catholic criteria for prudential judgment and direction in developing current policy-making. With knowledge of these social principles, in combination with our faith, we will be more armed and informed as to articulate the Catholic vision of reality, the truthful nature of the human person and society, to apply and integrate the social teachings in our everyday administrative and clinical encounters, and through the virtue of charity take action within the social, political, and economic spheres in which we have influence...
February 2017: Linacre Quarterly
https://www.readbyqxmd.com/read/28392176/increased-frequency-of-topical-steroids-provides-benefit-in-patients-with-recalcitrant-postsurgical-macular-edema
#13
Peter A Campochiaro, Yong S Han, Tahreem A Mir, Saleema Kherani, Gulnar Hafiz, Claudia Krispel, T Y Alvin Liu, Jiangxia Wang, Adrienne W Scott, Ingrid Zimmer-Galler
PURPOSE: To compare standard and frequent topical steroids for postsurgical macular edema (ME) DESIGN: Randomized clinical trial METHODS: Subjects with postsurgical ME stratified into post-cataract surgery ME (PCSME) and post-other surgery ME (POSME) were randomized to ketorolac four times a day (qid) + 1% prednisolone acetate (PA) every hour while awake (q1hWA, group 1) or qid (group 2). Mean change from baseline best corrected visual acuity (BCVA) was determined at week 12 after which group 2 subjects with persistent edema were crossed over to PA q1hWA...
April 6, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28386368/diffusional-kurtosis-imaging-in-evaluating-the-secondary-change-of-corticospinal-tract-after-unilateral-cerebral-infarction
#14
Shun Zhang, Wenjie Zhu, Yan Zhang, Yihao Yao, Jingjing Shi, Cong-Yi Wang, Wenzhen Zhu
We investigated to evaluate whether diffusional kurtosis imaging (DKI) can early detect the microstructure change of corticospinal tract (CST) after unilateral cerebral infarction solely in middle cerebral artery (MCA) territory. Seventy-seven patients with MCA territory infarct consisting of 10 subjects of hyperacute phase, 22 subjects of acute phase, 28 subjects of subacute phase and 17 subjects of chronic phase were enrolled in this study. ROI method was performed to measure the mean value of the infarcted area and the areas which belongs to CST [including the posterior limb of internal capsule (PLIC), cerebral peduncle (CP), pons, and medulla] in both ipsilateral and contralateral mirror side in all the DKI-derived parametric maps...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28378252/intravitreal-dexamethasone-implant-for-recalcitrant-cystoid-macular-edema-secondary-to-retinitis-pigmentosa-a-pilot-study
#15
Aditya Sudhalkar, Laurent Kodjikian, Nishikant Borse
BACKGROUND: To determine the utility of the intravitreal dexamethasone implant as therapy for cystoid macular edema (CME) secondary to retinitis pigmentosa (RP) recalcitrant to carbonic anhydrase inhibitor therapy over 2 years as a pilot study. METHODS: This was a prospective case series. Patients who showed either an incomplete or no response to topical dorzolamide for at least 1 month and oral acetazolamide therapy for at least 15 days were recruited for the study with informed consent...
April 4, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28375788/real-world-experience-with-half-time-versus-half-dose-photodynamic-therapy-in-chronic-central-serous-chorioretinopathy
#16
Shu-Yen Peng, Chi-Chun Lai, Nan-Kai Wang, Wei-Chi Wu, Yih-Shiou Hwang, Kuan-Jen Chen, Lee-Jen Chen, Shawn Tsai, Wei-Chun Chan, Laura Liu, Ling Yeung
PURPOSE: To evaluate the real-world experience with half-time photodynamic therapy (PDT) versus half-dose PDT for chronic central serous chorioretinopathy (CSC). METHODS: This multicenter retrospective study enrolled patients who received half-time PDT (with irradiation time shortened to 42 s) or half-dose PDT (with the dosage of verteporfin reduced to 3 mg/m(2)) for chronic CSC and who were followed up for ≧12 months. The success rate, central subfield retinal thickness (CST), and best-corrected visual acuity (BCVA) were documented in each group of patients...
April 4, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28371068/clara-immerwahr-award-for-sandra-luber-alwin-mittasch-prize-for-xinhe-bao-and-david%C3%A2-j-cole-hamilton-jochen-block-prize-for-maricruz-sanchez-sanchez-barbara-albert-elected-to-the-berlin-brandenburg-academy-of-sciences-and-humanities-wiley-cst-green-chemistry
#17
https://www.readbyqxmd.com/read/28367509/the-stability-of-insulin-solutions-in-syringes-is-improved-by-ensuring-lower-molecular-weight-silicone-lubricants-are-absent
#18
Lamees Nayef, Madiha F Khan, Michael A Brook
Protein drugs such as insulin are almost universally delivered via glass syringes lubricated with silicone oil. It is not uncommon for prefilled syringes (PFS) to become cloudy, which may affect bioavailability or total drug dose. To examine the role, if any, of the silicone oil lubricant in this process, a systematic evaluation of the degree of insulin denaturation and aggregation as a function of silicone oils of different molecular weights was undertaken. The former was measured using fluorescence changes of aqueous insulin/silicone dispersions, while the latter examined changes in turbidity as a function of mixing and silicone oil type; the results were confirmed at two different insulin concentrations and agitation speeds...
March 2017: Heliyon
https://www.readbyqxmd.com/read/28366536/the-human-ctc1-stn1-ten1-complex-regulates-telomere-maintenance-in-alt-cancer-cells
#19
Chenhui Huang, Pingping Jia, Megan Chastain, Olga Shiva, Weihang Chai
Maintaining functional telomeres is important for long-term proliferation of cells. About 15% of cancer cells are telomerase-negative and activate the alternative-lengthening of telomeres (ALT) pathway to maintain their telomeres. Recent studies have shown that the human CTC1/STN1/TEN1 complex (CST) plays a multi-faceted role in telomere maintenance in telomerase-expressing cancer cells. However, the role of CST in telomere maintenance in ALT cells is unclear. Here, we report that human CST forms a functional complex localizing in the ALT-associated PML bodies (APBs) in ALT cells throughout the cell cycle...
March 30, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28362239/associations-between-clinical-outcome-and-navigated-transcranial-magnetic-stimulation-characteristics-in-patients-with-motor-eloquent-brain-lesions-a-combined-navigated-transcranial-magnetic-stimulation-diffusion-tensor-imaging-fiber-tracking-approach
#20
Nico Sollmann, Noémie Wildschuetz, Anna Kelm, Neal Conway, Tobias Moser, Lucia Bulubas, Jan S Kirschke, Bernhard Meyer, Sandro M Krieg
OBJECTIVE Navigated transcranial magnetic stimulation (nTMS) and diffusion tensor imaging fiber tracking (DTI FT) based on nTMS data are increasingly used for preoperative planning and resection guidance in patients suffering from motor-eloquent brain tumors. The present study explores whether nTMS-based DTI FT can also be used for individual preoperative risk assessment regarding surgery-related motor impairment. METHODS Data derived from preoperative nTMS motor mapping and subsequent nTMS-based tractography in 86 patients were analyzed...
March 31, 2017: Journal of Neurosurgery
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