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https://www.readbyqxmd.com/read/28934486/stn1-pola2-interaction-provides-a-basis-for-primase-pol-%C3%AE-stimulation-by-human-stn1
#1
Swapna Ganduri, Neal F Lue
The CST (CTC1-STN1-TEN1) complex mediates critical functions in maintaining telomere DNA and overcoming genome-wide replication stress. A conserved biochemical function of the CST complex is its primase-Pol α (PP) stimulatory activity. In this report, we demonstrate the ability of purified human STN1 alone to promote PP activity in vitro. We show that this regulation is mediated primarily by the N-terminal OB fold of STN1, but does not require the DNA-binding activity of this domain. Rather, we observed a strong correlation between the PP-stimulatory activity of STN1 variants and their abilities to bind POLA2...
September 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28934437/group-b-streptococcus-and-the-vaginal-microbiota
#2
Geoffrey H Rosen, Tara M Randis, Purnahamsi V Desai, Katherine J Sapra, Bing Ma, Pawel Gajer, Michael S Humphrys, Jacques Ravel, Shari E Gelber, Adam J Ratner
Background: Streptococcus agalactiae (group B Streptococcus [GBS]) is an important neonatal pathogen and emerging cause of disease in adults. The major risk factor for neonatal disease is maternal vaginal colonization. However, little is known about the relationship between GBS and vaginal microbiota. Methods: Vaginal lavage samples from nonpregnant women were tested for GBS, and amplicon-based sequencing targeting the 16S ribosomal RNA V3-V4 region was performed...
September 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28926131/region-specific-impairment-of-the-cervical-spinal-cord-sc-in-amyotrophic-lateral-sclerosis-a-preliminary-study-using-sc-templates-and-quantitative-mri-diffusion-tensor-imaging-inhomogeneous-magnetization-transfer
#3
Henitsoa Rasoanandrianina, Aude-Marie Grapperon, Manuel Taso, Olivier M Girard, Guillaume Duhamel, Maxime Guye, Jean-Philippe Ranjeva, Shahram Attarian, Annie Verschueren, Virginie Callot
In this preliminary study, our objective was to investigate the potential of high-resolution anatomical imaging, diffusion tensor imaging (DTI) and conventional/inhomogeneous magnetization transfer imaging [magnetization transfer (MT)/inhomogeneous magnetization transfer (ihMT)] at 3 T, analyzed with template-extracted regions of interest, to measure the atrophy and structural changes of white (WM) and gray (GM) matter spinal cord (SC) occurring in patients with amyotrophic lateral sclerosis (ALS). Ten patients with ALS and 20 age-matched healthy controls were recruited...
September 19, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28922177/project-career-an-individualized-postsecondary-approach-to-promoting-independence-functioning-and-employment-success-among-students-with-traumatic-brain-injuries
#4
Deborah Minton, Eileen Elias, Phillip Rumrill, Deborah J Hendricks, Karen Jacobs, Anne Leopold, Amanda Nardone, Elaine Sampson, Marcia Scherer, Aundrea Gee Cormier, Aiyana Taylor, Caitlin DeLatte
BACKGROUND: Project Career is a five-year interdisciplinary demonstration project funded by NIDILRR. It provides technology-driven supports, merging Cognitive Support Technology (CST) evidence-based practices and rehabilitation counseling, to improve postsecondary and employment outcomes for veteran and civilian undergraduate students with traumatic brain injury (TBI). GOAL: Provide a technology-driven individualized support program to improve career and employment outcomes for students with TBI...
September 14, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28918571/the-effect-of-communication-skills-training-on-patient-pharmacist-communication-in-pharmacy-education-a-meta-analysis
#5
REVIEW
Hye Kyung Jin, Jae Hee Choi, Ji Eun Kang, Sandy Jeong Rhie
Communication skills in pharmacy education and practice are increasingly regarded as a crucial component. However, thus far, estimating of the overall communication skills training (CST) effects in a variety of outcomes is lacking. The aim of this study was to synthesize the effects of CST in pharmacy education by performing a meta-analysis of CST studies. We searched MEDLINE, EMBASE, ERIC, CINAHL, PsycINFO, Cochrane Library, Web of Science, Communication and Mass Media Complete (CMMC), key journals, and bibliographic databases...
September 16, 2017: Advances in Health Sciences Education: Theory and Practice
https://www.readbyqxmd.com/read/28904231/interactions-between-the-corticospinal-tract-and-premotor-motor-pathways-for-residual-motor-output-after-stroke
#6
Robert Schulz, Eunhee Park, Jungsoo Lee, Won Hyuk Chang, Ahee Lee, Yun-Hee Kim, Friedhelm C Hummel
BACKGROUND AND PURPOSE: Brain imaging has continuously enhanced our understanding how different brain networks contribute to motor recovery after stroke. However, the present models are still incomplete and do not fit for every patient. The interaction between the degree of damage of the corticospinal tract (CST) and of corticocortical motor connections, that is, the influence of the microstructural state of one connection on the importance of another has been largely neglected. METHODS: Applying diffusion-weighted imaging and probabilistic tractography, we investigated cross-network interactions between the integrity of ipsilesional CST and ipsilesional corticocortical motor pathways for variance in residual motor outcome in 53 patients with subacute stroke...
September 13, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28903767/treatment-of-biofilms-in-bacterial-vaginosis-by-an-amphoteric-tenside-pessary-clinical-study-and-microbiota-analysis
#7
Cornelia Gottschick, Zhi-Luo Deng, Marius Vital, Clarissa Masur, Christoph Abels, Dietmar H Pieper, Manfred Rohde, Werner Mendling, Irene Wagner-Döbler
BACKGROUND: Bacterial vaginosis (BV) is the most common vaginal syndrome among women in their reproductive years. It is associated with an increased risk of acquiring sexually transmitted infections and complications like preterm labor. BV is characterized by a high recurrence rate for which biofilms frequently found on vaginal epithelial cells may be a reason. RESULTS: Here, we report a controlled randomized clinical trial that tested the safety and effectiveness of a newly developed pessary containing an amphoteric tenside (WO3191) to disrupt biofilms after metronidazole treatment of BV...
September 13, 2017: Microbiome
https://www.readbyqxmd.com/read/28889032/non-destructive-study-of-wood-using-the-compton-scattering-technique
#8
Akash Tondon, Mohinder Singh, B S Sandhu, Bhajan Singh
A simple nondestructive method is presented in this study to characterize woods having different densities, thus estimating the size and depth of inhomogeneities in given wood samples using the Compton scattering technique (CST). This technique uses a collimated beam of 662-keV energy from (137)Cs radioactive source, and the scattered flux is detected by an NaI(Tl) detector. To characterize different wood samples on the basis of their densities, both scattering and transmission experiments were performed. The presence of inhomogeneities such as knots in wood was simulated by drilling cylindrical voids of diameter 9mm in the samples and then filling them with a high-density material (aluminum)...
August 31, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28887469/analysis-of-mutual-couplings-in-a-concentric-circular-ring-plasmonic-optical-antenna-array
#9
Guiru Gu, Lin Li, Yingjie Zhang, Thitikorn Kemsri, Xuejun Lu
In this paper, we report the analysis of a concentric circular ring plasmonic optical antenna (POA) array using a simple lumped coupled circuit (LCC) model. The currents in the circular rings of the POA array and their mutual couplings are analyzed using the LCC model. The results agree well with the numerical simulation using CST's Microwave Studio®. The LCC model reveals the mutual couplings between the antenna rings. It is found that the mutual couplings are not only between the adjacent antenna rings, but also involve their second (2(nd)) nearest or farther neighbors...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28884027/aav-klf7-promotes-descending-propriospinal-neuron-axonal-plasticity-after-spinal-cord-injury
#10
Wen-Yuan Li, Ying Wang, Feng-Guo Zhai, Ping Sun, Yong-Xia Cheng, Ling-Xiao Deng, Zhen-Yu Wang
DPSN axons mediate and maintain a variety of normal spinal functions. Unsurprisingly, DPSN tracts have been shown to mediate functional recovery following SCI. KLF7 could contribute to CST axon plasticity after spinal cord injury. In the present study, we assessed whether KLF7 could effectively promote DPSN axon regeneration and synapse formation following SCI. An AAV-KLF7 construct was used to overexpress KLF7. In vitro, KLF7 and target proteins were successfully elevated and axonal outgrowth was enhanced...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28881430/distinctive-effects-between-cognitive-stimulation-and-reminiscence-therapy-on-cognitive-function-and-quality-of-life-for-different-types-of-behavioural-problems-in-dementia
#11
Hsiu-Ching Lin, Ya-Ping Yang, Wen-Yun Cheng, Jing-Jy Wang
BACKGROUND: Among the various complementary therapies for patients with dementia (PwD), cognitive stimulation therapy (CST) and reminiscence therapy (RT) are frequently used to improve cognitive function and quality of life. However, no studies have examined the use of complementary therapies applied to different types of behavioural and psychological symptoms of dementia in PwD. AIMS: The purpose of this study was to investigate the distinctive effects of CST and RT on cognitive function and quality of life for PwD with three types of behavioural problems - the dispute, return and dissociate types...
September 7, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28878691/spontaneous-preterm-birth-is-associated-with-differential-expression-of-vaginal-metabolites-by-lactobacilli-dominated-microflora
#12
Graham P Stafford, Jennifer L Parker, Emmanuel Amabebe, James Kistler, Steven Reynolds, Victoria Stern, Martyn Paley, Dilly O C Anumba
A major challenge in preventing preterm birth (PTB) is identifying women at greatest risk. This pilot study prospectively examined the differences in vaginal microbiota and metabolite profiles of women who delivered prematurely compared to their term counterparts in a cohort of asymptomatic (studied at 20-22, n = 80; and 26-28 weeks, n = 41) and symptomatic women (studied at 24-36 weeks, n = 37). Using 16S rRNA sequencing, the vaginal microbiota from cervicovaginal fluid samples was characterized into five Community State Types (CST) dominated by Lactobacillus spp...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28874926/craniosacral-therapy-and-visceral-manipulation-a-new-treatment-intervention-for-concussion-recovery
#13
Gail Wetzler, Melinda Roland, Sally Fryer-Dietz, Dee Dettmann-Ahern
Background: Military service members and veterans face health issues related to traumatic brain injury (TBI), especially during combat, use of heavy equipment, and exposures to environmental hazards and explosives. There were 400,000 TBIs reported in deployed U.S. troops in 2012. Athletes are also subject to TBI. Studies have indicated that some manual therapies could be helpful for treating patients who have post-concussive syndrome. Objective: This case series report describes the effects of CranioSacral Therapy (CST), Visceral Manipulation (VM), and Neural Manipulation (NM) modalities for treating patients who have post-concussion syndrome...
August 1, 2017: Medical Acupuncture
https://www.readbyqxmd.com/read/28872898/effects-of-a-telephone-and-web-based-coping-skills-training-program-compared-to-an-education-program-for-survivors-of-critical-illness-and-their-family-members-a-randomized-clinical-trial
#14
Christopher E Cox, Catherine L Hough, Shannon S Carson, Douglas B White, Jeremy M Kahn, Maren K Olsen, Derek M Jones, Tamara J Somers, Sarah A Kelleher, Laura S Porter
RATIONALE: Many survivors of critical illness and their family members experience significant psychological distress after discharge. OBJECTIVES: To compare effects of a coping skills training (CST) program with an education program on patient and family psychological distress. METHODS: In this 5-center clinical trial, adult patients who received mechanical ventilation >48 hours and one family member of each patient were randomized to six weekly CST telephone sessions plus access to a study website or a critical illness education program...
September 5, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28866955/cross-country-analysis-of-faecal-sludge-dewatering
#15
Moritz Gold, Hidenori Harada, Jean-David Therrien, Takahiro Nishida, Michael Cunningham, Swaib Semiyaga, Shigeo Fujii, Caetano Dorea, Viet-Anh Nguyen, Linda Strande
Dewatering of faecal sludge (FS) is indispensable for adequate FS management. However, comprehensive knowledge is lacking on FS dewatering performance. This study compared the dewatering performance of FS from different countries and onsite sanitation technologies, to assess influential characteristics on dewatering, and to compare dewatering performance of FS with wastewater sludge. We collected 73 FS samples from septic tanks, lined pit latrines, unlined pit latrines, and johkasou tanks in Uganda, Vietnam and Japan, and 18 samples of wastewater sludge in Switzerland...
September 4, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28865185/developmental-morphology-and-topography-of-the-components-of-the-cervical-sympathetic-trunk-in-sheep-ovis-aries-during-the-fetal-period
#16
Jamal Nourinezhad, Saleh Bamohabat, Yazdan Mazaheri
The objective of this study was to clarify the typical architecture and morphological variations of cervical sympathetic trunk (CST) in sheep during fetal period. Components of CST were examined on both sides of 40 male and female sheep fetuses aged from 60-140 days under a stereomicroscope. Skeletotopy and frequency of presence of cranial cervical ganglion (CCG), syntopy of cervical ganglia, and composition and topography of vagosympathetic trunk were consistent among specimens whereas the shape of cervical ganglia, the skeletotopy and number of three middle cervical ganglia (MG), and the frequency of communicating branches of CCG to the first cervical spinal nerve exhibited differences during fetal period...
September 2, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28860902/optimal-factors-of-diffusion-tensor-imaging-predicting-corticospinal-tract-injury-in-patients-with-brain-tumors
#17
Zhi-Gang Min, Chen Niu, Qiu-Li Zhang, Ming Zhang, Yu-Cheng Qian
OBJECTIVE: To identify the optimal factors in diffusion tensor imaging for predicting corticospinal tract (CST) injury caused by brain tumors. MATERIALS AND METHODS: This prospective study included 33 patients with motor weakness and 64 patients with normal motor function. The movement of the CST, minimum distance between the CST and the tumor, and relative fractional anisotropy (rFA) of the CST on diffusion tensor imaging, were compared between patients with motor weakness and normal function...
September 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/28860468/characterization-of-cervico-vaginal-microbiota-in-women-developing-persistent-high-risk-human-papillomavirus-infection
#18
Monica Di Paola, Cristina Sani, Ann Maria Clemente, Anna Iossa, Eloisa Perissi, Giuseppe Castronovo, Michele Tanturli, Damariz Rivero, Federico Cozzolino, Duccio Cavalieri, Francesca Carozzi, Carlotta De Filippo, Maria Gabriella Torcia
Changes in cervico-vaginal microbiota with Lactobacillus depletion and increased microbial diversity facilitate human papillomavirus (HPV) infection and might be involved in viral persistence and cancer development. To define the microbial Community State Types (CSTs) associated with high-risk HPV-persistence, we analysed 55 cervico-vaginal samples from HPV positive (HPV+) women out of 1029 screened women and performed pyrosequencing of 16S rDNA. A total of 17 samples from age-matched HPV negative (HPV-) women were used as control...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28857581/bridging-the-gap-between-conventional-and-standardized-competency-to-stand-trial-cst-assessments-an-examination-of-defendant-answers-to-conventional-cst-questions
#19
Anthony M Tarescavage, Lynn Luna Jones, Tayla T C Lee
Despite research suggesting that use of forensic assessment instruments of competency to stand trial (CST) can improve the integrity of forensic conceptualizations (Rogers & Johansson-Love, 2009), the majority of evaluators do not use these measures in CST evaluations (Nicholson & Norwood, 2000). The purpose of this study is to bridge the gap between competency evaluations based on a conventional interview and those conducted with the aid of a standardized forensic assessment instrument. To this end, we utilized an archival sample of 704 criminal defendants (543 males, 161 females) ordered to undergo evaluations of CST...
August 31, 2017: Law and Human Behavior
https://www.readbyqxmd.com/read/28852030/the-association-between-substance-p-and-white-matter-integrity-in-medication-naive-patients-with-major-depressive-disorder
#20
Eunsoo Won, June Kang, Sunyoung Choi, Aram Kim, Kyu-Man Han, Ho-Kyoung Yoon, Su-Hee Cho, Woo-Suk Tae, Min-Soo Lee, Sook-Haeng Joe, Yong-Ku Kim, Byung-Joo Ham
Substance P (SP) has been implicated in major depressive disorder (MDD), with SP antagonists being studied as potential antidepressants. Although impaired neural plasticity is considered a key mechanism in MDD pathophysiology, the association between SP and brain structural changes in depression has not been investigated. We investigated the correlations between SP levels and white matter (WM) integrity in 42 medication-naive patients with MDD and 57 healthy controls (HCs). Plasma levels of SP were determined, and diffusion tensor imaging (DTI) was performed to investigate microstructural changes in WM tracts...
August 29, 2017: Scientific Reports
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