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https://www.readbyqxmd.com/read/29913374/fluctuation-of-the-left-ventricular-ejection-fraction-in-patients-with-her2-positive-early-breast-cancer-treated-by-12-months-of-adjuvant-trastuzumab
#1
Quentin Jacquinot, Sophie Paget-Bailly, Pierre Fumoleau, Gilles Romieu, Jean Yves Pierga, Marc Espié, Alain Lortholary, Jean Marc Nabholtz, Celine Faure Mercier, Iris Pauporté, Julie Henriques, Xavier Pivot
BACKGROUND: Cardiac toxicity with a decrease of the left ventricular ejection fraction (LVEF) is the main side effect induced by trastuzumab. This study reports the fluctuation of LVEF over the 12 months of adjuvant trastuzumab in PHARE trial (NCT00381901). METHODS: LVEF assessment was performed every 3 months while patients received trastuzumab and after completion of treatment over the first 2 years and then every 6 months afterwards. The fluctuations of LVEF over time were described and a logistic regression model was performed investigating associated factors to LVEF perfect recovery at baseline value...
June 15, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29912269/medication-management-performance-and-associated-cognitive-correlates-in-healthy-older-adults-and-older-adults-with-amci
#2
Catherine A Sumida, Thao T Vo, Emily J Van Etten, Maureen Schmitter-Edgecombe
Objective: Difficulties managing medications, particularly among older adults experiencing cognitive deficits, is an important contributing factor to medication nonadherence that may have significant negative financial and health outcomes. The current study examined the performance of healthy older adults' (HOA) and individuals with amnestic mild cognitive impairment (aMCI) on the medication management abilities assessment's (MMAA, a performance-based measure of medication management) original scoring criteria and derived error process measures, assessing medication overtaking and undertaking magnitude...
April 18, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29912247/-the-challenge-in-colistin-dosing-updating-available-recommendations
#3
Ruth Rosales, Loreto Rojas, Francisco Zamora, Giannina Izquierdo, Claudia Benavides, Claudio González
Polymyxins have been available since the 1960s, however, because of their adverse effects, their use has been reserved for the treatment of infections caused by multiresistant bacteria. The increase in the clinical experience acquired in recent years and the published medical literature have raised doubts about the information provided by the product, indicating the need to update dosage recommendations, pharmacokinetics and pharmacokinetic/pharmacodynamic information (PK/PD). In addition, differences in concentration and dose between the different products of colistin may lead to errors of indication/administration and pose a risk to patients...
April 2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29912034/vestibular-rehabilitation-is-associated-with-visuovestibular-improvement-in-pediatric-concussion
#4
Eileen P Storey, Douglas J Wiebe, Bernadette A DʼAlonzo, Kim Nixon-Cave, Janet Jackson-Coty, Arlene M Goodman, Matthew F Grady, Christina L Master
BACKGROUND AND PURPOSE: Vision and vestibular-related deficits are common after concussion and are associated with prolonged recovery times, substantially impacting the quality of life for children. The utility of targeted vestibular rehabilitation for these deficits in children after concussion is unknown. The purpose of this study was to determine whether active vestibular rehabilitation is associated with an improvement in visuovestibular signs and symptoms in children with concussion...
July 2018: Journal of Neurologic Physical Therapy: JNPT
https://www.readbyqxmd.com/read/29912025/using-lean-to-enhance-heart-failure-patient-identification-processes-and-increase-core-measure-scores
#5
Jennifer R Hunt, Kelli Jo Ouellette, Michelle Reece
BACKGROUND: Heart failure (HF) is the leading cause of hospitalization among older adults in the United States. Health systems target readmission rates for quality improvement and cost reduction. LOCAL PROBLEM: Heart failure core measure (CM) scores at our medical center were lower than the national average, and methods for capturing the appropriate documentation on HF patients to ensure CM compliance were not clear. METHODS: An interdisciplinary team determined barriers to increasing CM scores, gathered baseline data, and identified gaps in the existing process...
June 14, 2018: Journal of Nursing Care Quality
https://www.readbyqxmd.com/read/29911647/reliability-of-pressure-pain-threshold-testing-in-healthy-pain-free-young-adults
#6
Robert Waller, Leon Straker, Peter O'Sullivan, Michele Sterling, Anne Smith
Background and aims Investigation of the multidimensional correlates of pressure pain threshold (PPT) requires the study of large cohorts, and thus the use of multiple raters, for sufficient statistical power. Although PPT testing has previously been shown to be reliable, the reliability of multiple raters and investigation for systematic bias between raters has not been reported. The aim of this study was to evaluate the intrarater and interrater reliability of PPT measurement by handheld algometer at the wrist, leg, cervical spine and lumbar spine...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911435/systemic-analysis-of-medication-administration-omission-errors-in-a-tertiary-care-hospital-in-quebec
#7
Thomas G Poder, Serge Maltais
OBJECTIVE: Medication administration omission errors (MAOEs) occur frequently in hospitals and can significantly affect patient health. An interdisciplinary committee was formed in summer 2012 to analyse incident/accident reports (AH-223-1 forms) of MAOEs for the 2011-2012 fiscal year in order to identify contributing factors and to propose preventive solutions. Special attention was paid to events with consequences for patients. METHOD: An aggregate data analysis involving four major steps was conducted: sampling, categorisation, identification of contributing factors, and seeking preventive solutions...
January 1, 2018: Health Information Management: Journal of the Health Information Management Association of Australia
https://www.readbyqxmd.com/read/29911176/differences-in-hearing-acuity-among-normal-hearing-young-adults-modulate-the-neural-basis-for-speech-comprehension
#8
Yune S Lee, Arthur Wingfield, Nam-Eun Min, Ethan Kotloff, Murray Grossman, Jonathan E Peelle
In this paper, we investigate how subtle differences in hearing acuity affect the neural systems supporting speech processing in young adults. Auditory sentence comprehension requires perceiving a complex acoustic signal and performing linguistic operations to extract the correct meaning. We used functional MRI to monitor human brain activity while adults aged 18-41 years listened to spoken sentences. The sentences varied in their level of syntactic processing demands, containing either a subject-relative or object-relative center-embedded clause...
May 2018: ENeuro
https://www.readbyqxmd.com/read/29911039/determinants-of-vitamin-d-status-in-indian-school-children
#9
Rubina Mandlik, Neha Kajale, Veena Ekbote, Vivek Patwardhan, Vaman Khadilkar, Shashi Chiplonkar, Anuradha Khadilkar
Introduction: Due to the high prevalence of Vitamin D deficiency in spite of abundant sunshine and scarcity of studies investigating Vitamin D status in Indian children from rural and semirural areas, the objectives of this cross-sectional study were to: (1) assess the Vitamin D status of school-children in a semi-rural setting and (2) identify the determinants of Vitamin D status in these children. Materials and Methods: Data collected included anthropometric measurements (height and weight), body composition, three-one-day dietary recall method, demographic data, and sunlight exposure...
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29910835/supportive-care-needs-of-multicultural-patients-with-cancer-in-the-united-arab-emirates
#10
Satish Chandrasekhar Nair, Hassan Jaafar, Mohamed Jaloudi, Khaled Qawasmeh, Afra AlMarar, Halah Ibrahim
Despite the high prevalence of cancer in the Middle East, there is limited published data reporting the needs of cancer patients in this region of the world. The purpose of this study is to assess the unmet supportive care needs of oncology patients in the United Arab Emirates (UAE). From December 2014 to December 2016, a cross-sectional survey of cancer patients was conducted at a large tertiary care hospital and an oncology referral centre in the UAE, using a validated Arabic translation of the supportive care needs survey--short form (SCNS-SF34-A), assessing cancer-specific perceived needs across five domains: psychological, health system information, patient care and support, physical and daily living and sexuality...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29909577/population-pharmacokinetic-model-for-tumescent-lidocaine-in-women-undergoing-breast-cancer-surgery
#11
Camille Riff, Aurélie Bourgoin, Amelie Marsot, Laurent Allanioux, Marc Leone, Olivier Blin, Romain Guilhaumou
PURPOSE: Tumescent lidocaine anesthesia (TLA) is an opportunity to perform mastectomy for breast cancer without general anesthesia in elderly women. Few reports are available on the pharmacokinetics of lidocaine in a context of TLA during a unilateral mastectomy. The aim of this study was to describe lidocaine pharmacokinetics in elderly women undergoing breast cancer surgery after TLA and to explore the risk of the toxicity of this technique. METHODS: A prospective study was conducted to examine the pharmacokinetics of lidocaine in women undergoing TLA...
June 16, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29909507/what-is-the-relationship-between-eosinophilic-esophagitis-eoe-and-aeroallergens-implications-for-allergen-immunotherapy
#12
REVIEW
Maureen Egan, Dan Atkins
PURPOSE OF REVIEW: Observations suggesting that aeroallergens trigger eosinophilic esophagitis (EoE) in a subset of patients raise questions about the implications this finding has on the evaluation and management of patients with EoE, including a potential role for allergen immunotherapy. RECENT FINDINGS: The majority of studies evaluating the potential role of aeroallergens as provocateurs of EoE have addressed this issue by assessing the seasonal variation in EoE diagnosis and/or symptom onset or worsening, with mixed results...
June 16, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29909459/electrochemical-nonenzymatic-sensor-for-cholesterol-determination-in-food
#13
Ksenia Derina, Elena Korotkova, Yekaterina Taishibekova, Lyazat Salkeeva, Bohumil Kratochvil, Jiri Barek
The treatment of some inborn metabolism errors requires cholesterol substitution therapy. Cholesterol plays a vital role in the human body. Therefore, the majority of cholesterol determination techniques are targeted to blood and blood serum. Nevertheless, cholesterol determination in food is important as well. In this paper, cholesterol determination using differential pulse voltammetry (DPV) in dairy products (e.g., milk, clotted cream, yogurt, butter, etc.) is reported with a novel nonenzymatic sensor based on diphosphonic acid of 1,4-diacetylglycoluril (DPADGU) as an electrode surface modifier...
June 16, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29908699/key-parameters-controlling-the-development-of-constant-pattern-isotachic-trains-of-two-rare-earth-elements-in-ligand-assisted-displacement-chromatography
#14
Hoon Choi, David Harvey, Yi Ding, Nien-Hwa Linda Wang
Ligand-assisted displacement chromatography (LAD) has been developed for separating rare earth elements since the 1950's. Isotachic displacement trains, which are similar to those in conventional displacement chromatography, were reported previously. However, there has been no general theory delineating the conditions required to form constant-pattern displacement trains for non-ideal systems (or systems with significant mass transfer resistance). The constant-pattern state is critical for obtaining pure products with high yield and high productivity...
May 30, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29907888/reengineering-workflow-for-curation-of-dicom-datasets
#15
William Bennett, Kirk Smith, Quasar Jarosz, Tracy Nolan, Walter Bosch
Reusable, publicly available data is a pillar of open science and rapid advancement of cancer imaging research. Sharing data from completed research studies not only saves research dollars required to collect data, but also helps insure that studies are both replicable and reproducible. The Cancer Imaging Archive (TCIA) is a global shared repository for imaging data related to cancer. Insuring the consistency, scientific utility, and anonymity of data stored in TCIA is of utmost importance. As the rate of submission to TCIA has been increasing, both in volume and complexity of DICOM objects stored, the process of curation of collections has become a bottleneck in acquisition of data...
June 15, 2018: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29907648/the-spectrum-of-replication-errors-in-the-absence-of-error-correction-assayed-across-the-whole-genome-of-escherichia-coli
#16
Brittany A Niccum, Heewook Lee, Wazim MohammedIsmail, Haixu Tang, Patricia L Foster
When the DNA polymerase that replicates the Escherichia coli chromosome, DNA Pol III, makes an error, there are two primary defenses against mutation: proofreading by the epsilon subunit of the holoenzyme and mismatch repair. In proofreading deficient strains, mismatch repair is partially saturated and the cell's response to DNA damage, the SOS response, may be partially induced. To investigate the nature of replication errors, we used mutation accumulation experiments and whole genome sequencing to determine mutation rates and mutational spectra across the entire chromosome of strains deficient in proofreading, mismatch repair, and the SOS response...
June 15, 2018: Genetics
https://www.readbyqxmd.com/read/29907629/cataract-surgery-refractive-outcomes-representative-standards-in-a-national-health-service-setting
#17
Kerr Brogan, Charles J M Diaper, Alan P Rotchford
BACKGROUND/AIMS: To report refractive outcomes from an National Health Service (NHS) cataract surgery service and assess if results meet suggested benchmark standard. METHODS: Details of all patients undergoing cataract surgery in the Southern General and New Victoria hospitals in Glasgow, UK, between November 2006 and December 2016 were prospectively entered into an electronic database. Patients were reviewed 4 weeks postoperatively in the eye clinic and underwent refraction at their local optometrist prior to this appointment...
June 15, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29907057/absolute-proton-hydration-free-energy-surface-potential-of-water-and-redox-potential-of-the-hydrogen-electrode-from-first-principles-qm-mm-md-free-energy-simulations-of-sodium-and-potassium-hydration
#18
Thomas S Hofer, Philippe H Hünenberger
The absolute intrinsic hydration free energy GH+ ,wat ◦ of the proton, the surface electric potential jump χwat ◦ upon entering bulk water, and the absolute redox potential VH+ ,wat ◦ of the reference hydrogen electrode are cornerstone quantities for formulating single-ion thermodynamics on absolute scales. They can be easily calculated from each other but remain fundamentally elusive, i.e., they cannot be determined experimentally without invoking some extra-thermodynamic assumption (ETA). The Born model provides a natural framework to formulate such an assumption (Born ETA), as it automatically factors out the contribution of crossing the water surface from the hydration free energy...
June 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29906414/guide-rna-selection-for-crispr-cas9-transfections-in-plasmodium-falciparum
#19
Jose M Ribeiro, Meera Garriga, Nicole Potchen, Anna K Crater, Ankit Gupta, Daisuke Ito, Sanjay A Desai
CRISPR-Cas9 mediated genome editing is addressing key limitations in the transfection of malaria parasites. While this method has already simplified the needed molecular cloning and reduced the time required to generate mutants in the human pathogen Plasmodium falciparum, optimal selection of required guide RNAs and guidelines for successful transfections have not been well characterized, leading workers to use time-consuming trial and error approaches. We used a genome-wide computational approach to create a comprehensive and publicly accessible database of possible guide RNA sequences in the P...
June 12, 2018: International Journal for Parasitology
https://www.readbyqxmd.com/read/29906305/pilot-evaluation-of-home-delivery-programme-in-haemophilia
#20
J E Megías-Vericat, E Monte-Boquet, M Martín-Cerezuela, M J Cuéllar-Monreal, M V Tarazona-Casany, P Pérez-Huertas, S Bonanad, J L Poveda-Andrés
WHAT IS KNOWN AND OBJECTIVES: Most of the clotting factor (CF) dispensations to haemophiliac patients are centralized in a few haemophilia treatment centres, necessitating frequent visits and long travel distances. The aim was to evaluate the home delivery programme developed by the Outpatient Pharmaceutical Care Unit (OPCU) through the association of patients (ASHECOVA). METHODS: A specific software programme was designed to communicate the individual CF requirements...
June 15, 2018: Journal of Clinical Pharmacy and Therapeutics
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