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"Conflict of interest"

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https://www.readbyqxmd.com/read/28212133/potential-uselessness-and-futility-of-left-atrial-appendage-occlusion-and-patent-foramen-ovale-closure-in-cardioembolic-stroke
#1
Gian L Nicolosi
International guidelines indicate that interventional closure of left atrial appendage and patent foramen ovale may be considered in selected patients for stroke prevention. These procedures appear, however, from the published literature, at high risk of uselessness and futility in the single case, if not even capable to induce harm and adverse events. In fact, all reported systematic reviews and meta-analyses have not shown in a convincing manner the superiority of these procedures in stroke prevention, taking into account the occurrence of possible complications also, as compared with alternative medical treatment...
February 16, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28203385/appraising-the-methodological-quality-of-the-clinical-practice-guideline-for-diabetes-mellitus-using-the-agree-ii-instrument-a-methodological-evaluation
#2
Mahmoud Radwan, Ali Akbari Sari, Arash Rashidian, Amirhossein Takian, Sanaa Abou-Dagga, Aymen Elsous
OBJECTIVES: To evaluate the methodological quality of the Palestinian Clinical Practice Guideline for Diabetes Mellitus using the Translated Arabic Version of the AGREE II. DESIGN: Methodological evaluation. A cross-cultural adaptation framework was followed to translate and develop a standardised Translated Arabic Version of the AGREE II. SETTING: Palestinian Primary Healthcare Centres. PARTICIPANTS: Sixteen appraisers independently evaluated the Clinical Practice Guideline for Diabetes Mellitus using the Translated Arabic Version of the AGREE II...
February 2017: JRSM Open
https://www.readbyqxmd.com/read/28202934/the-food-industry-and-conflicts-of-interest-in-nutrition-research-a-latin-american-perspective
#3
Joaquin Barnoya, Marion Nestle
Conflicts of interest arise when corporations marketing harmful products establish financial relationships with research institutions, researchers, or public health organizations. As obesity becomes a worldwide epidemic, such relationships threaten to jeopardize the integrity of scientific research. Latin America, a region undergoing rapid development, is particularly vulnerable to such conflicts. Here, we provide examples of how food and beverage companies are funding nutrition-focused research and institutions in Latin America, putting their credibility at risk...
December 2016: Journal of Public Health Policy
https://www.readbyqxmd.com/read/28196191/clarification-of-conflict-of-interest-disclosure
#4
(no author information available yet)
No abstract text is available yet for this article.
February 9, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28192600/systematic-reviews-and-meta-analyses-on-psoriasis-role-of-funding-sources-conflict-of-interest-and-bibliometric-indices-as-predictors-of-methodological-quality
#5
F Gómez-García, J Ruano, M Aguilar-Luque, J Gay-Mimbrera, B Maestre-Lopez, J L Sanz-Cabanillas, P J Carmona-Fernández, M González-Padilla, A Vélez García-Nieto, B Isla-Tejera
BACKGROUND: The quality of systematic reviews (SRs) and meta-analyses about psoriasis, a chronic inflammatory skin disease that severely impairs quality of life and is associated with high costs, remains unknown. OBJECTIVES: To assess the methodological quality of SRs published on psoriasis. METHODS: After a comprehensive search in MEDLINE, EMBASE, and the Cochrane Database (PROSPERO:CDR4201604161), the quality was assessed by two raters using Assessment of Multiple Systematic Reviews (AMSTAR) tool...
February 13, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28185466/-analytical-interference-leading-to-a-diagnosis-of-lymphoproliferative-disorder
#6
I Kurfürstová, T Šálek, E Kadlčková, M Pšenčík
BACKGROUND: Monoclonal immunoglobulins (paraproteins) are produced by B lymphocytes in lymphoproliferative disorders. A single monoclonal immunoglobulin is homogeneous in terms of its structure, and it can occur in human serum at high concentration and cause significant interference in laboratory assays. CASE: We present a case of an 84-year-old man who was admitted to the hospital for progression of dyspnea. Basic laboratory tests showed a serum concentration of conjugated bilirubin, measured using the diazo spectrophotometric method, which was much higher than that of total bilirubin...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28185463/-lymphoedema-following-regional-lymph-node-surgery-for-breast-cancer
#7
P Vrtělová, O Coufal, V Fait, L Gabrielová, O Zapletal
BACKGROUND: The treatment of breast cancer is based on the multimodal principle and surgery of regional lymph nodes is an inseparable part of this. Indication criteria are changing constantly folowing advances in other modalities. It is necessary to consider not only the diagnostic or therapeutic benefit but also to take into account adverse effects. Previous studies have demonstrated that axillary dissection (ALND) is burdened by a high frequency of chronic lymphoedema of the arm or chest wall; however, a considerable percentage of patients may also suffer from lymphoedema after sentinel lymph node biopsy (SLNB)...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28185462/-options-of-chemotherapy-in-the-treatment-of-prostate-cancer
#8
I Richter, J Dvořák, J Bartoš
BACKGROUND: Prostate cancer is one of the most common malignancies in men. Chemotherapy has an important role in the management of prostate cancer, especially for the treatment of castrate resistant prostate cancer (mCRPC). According to recently published studies, chemotherapy can also be used to treat advanced hormone sensitive disease. AIM: The aim of this report is to review the currently available options for chemotherapy of prostate cancer. RESULTS: Docetaxel is a chemotherapeutic agent used for standard treatment of mCRPC as 1st line therapy...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28185461/-epithelial-mesenchymal-transition-in-tumor-tissue-and-its-role-for-metastatic-spread-of-cancer
#9
V M Matějka, J Fínek, M Králíčková
BACKGROUND: Metastasis, recurrence, and resistance to chemotherapy are leading causes of the majority of cancer-related mortality worldwide. The process of metastasis can be artificially divided into a series of sequential, highly organized, and organ-specific steps. The underlying mechanisms are still poorly understood, but are believed to be mediated by epithelial-mesenchymal transition (EMT). First described in embryogenesis, EMT is a cellular reprogramming process in which epithelial cells acquire a mesenchymal phenotype...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28185460/-daratumumab-hope-for-myeloma-patients-a-challenge-for-clinical-laboratories
#10
T Jelínek, M Kořístka, Z Čermáková, R Hájek
Monoclonal antibodies represent a standard part in the treatment of oncologic patients, but their efficacy in multiple myeloma used to be unsatisfactory. Daratumumab monotherapy was approved by the American FDA in 2015, after unprecedented results were obtained in a heavily pre-treated group of patients. In 2016 daratumumab was approved in combination with lenalidomide and dexamethasone, or bortezomib and dexamethasone, for the treatment of myeloma patients who have received at least one prior therapy.The toxicity of the drug is low, and is dominated by infusion-related reactions in more or less half of patients...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28178695/german-guidelines-on-screening-diagnosis-and-treatment-of-alcohol-use-disorders
#11
Karl Mann, Anil Batra, Mira Fauth-Bühler, Eva Hoch
Evidence-based strategies for screening, diagnosing and treating alcohol use disorders (AUD) are instrumental in the early and better management of individuals at risk for or suffering from AUD. However, existing guidelines vary and may be biased by conflicts of interests. Unbiased recommendations can be achieved only if sufficient detail is provided on the composition and representativeness of author groups, methodological rigor, handling of potential conflicts of interest and financing. This paper presents the first evidence-based guidelines for AUD from German-speaking countries...
February 9, 2017: European Addiction Research
https://www.readbyqxmd.com/read/28167249/how-are-adjacent-spinal-levels-affected-by-vertebral-fracture-and-by-vertebroplasty-a-biomechanical-study-on-cadaveric-spines
#12
Jin Luo, Deborah J Annesley-Williams, Michael A Adams, Patricia Dolan
BACKGROUND CONTEXT: Spinal injuries and surgery may have important effects at neighbouring spinal levels, but previous investigations of adjacent-level biomechanics have produced conflicting results. We use 'stress profilometry' and non-contact strain measurements to investigate thoroughly this long-standing problem. PURPOSE: To determine how vertebral fracture and vertebroplasty affect compressive load-sharing and vertebral deformations at adjacent spinal levels...
February 3, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28167228/comparison-of-conflict-of-interest-among-published-hernia-researchers-self-reported-to-the-centers-of-medicare-and-medicaid-services-open-payments-database
#13
Oscar A Olavarria, Julie L Holihan, Deepa Cherla, Cristina A Perez, Lillian S Kao, Tien C Ko, Mike K Liang
INTRODUCTION: Many healthcare providers have financial interests and relationships with healthcare companies. In order to maintain transparency, investigators are expected to disclose their conflicts of interest (COI). Recently, the Centers of Medicare and Medicaid Services (CMS) developed an open payment database of COI reported by industry. We hypothesize there is discordance between industry-reported and physician self-reported COI among ventral hernia publications. METHODS: PubMed was searched for ventral hernia studies accepted for publication between June 2013 and October 2015 and published by authors from the United States...
February 3, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28164085/public-private-partnerships-in-cloud-computing-services-in-the-context-of-genomic-research
#14
REVIEW
Palmira Granados Moreno, Yann Joly, Bartha Maria Knoppers
Public-private partnerships (PPPs) have been increasingly used to spur and facilitate innovation in a number of fields. In healthcare, the purpose of using a PPP is commonly to develop and/or provide vaccines and drugs against communicable diseases, mainly in developing or underdeveloped countries. With the advancement of technology and of the area of genomics, these partnerships also focus on large-scale genomic research projects that aim to advance the understanding of diseases that have a genetic component and to develop personalized treatments...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28163210/are-people-with-chronic-low-back-pain-meeting-the-physical-activity-guidelines-a-co-twin-control-study
#15
Joshua Robert Zadro, Debra Shirley, Anita Amorim, Francisco Pérez-Riquelme, Juan R Ordoñana, Paulo H Ferreira
BACKGROUND: Despite a large amount of research investigating physical activity (PA) levels in people with chronic low back pain (LBP), no study has investigated whether people with chronic LBP are meeting the World Health Organization (WHO) PA guidelines. Furthermore, with genetics and the early shared environment substantially influencing the presence of LBP and PA engagement, these factors could confound the association between LBP and PA and need to be controlled for. PURPOSE: This study aimed to investigate the association between chronic LBP and meeting the PA guidelines, while controlling for the effects of genetics and early shared environment...
February 2, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28158281/is-investigator-background-related-to-outcome-in-head-to-head-trials-of-psychotherapy-and-pharmacotherapy-for-adult-depression-a-systematic-review-and-meta-analysis
#16
Ioana A Cristea, Claudio Gentili, Pietro Pietrini, Pim Cuijpers
BACKGROUND: The influence of factors related to the background of investigators conducting trials comparing psychotherapy and pharmacotherapy has remained largely unstudied. Specializations emphasizing biological determinants of mental disorders, like psychiatry, might favor pharmacotherapy, while others stressing psychosocial factors, like psychology, could promote psychotherapy. Yet financial conflict of interest (COI) could be a confounding factor as authors with a medical specialization might receive more sponsoring from the pharmaceutical industry...
2017: PloS One
https://www.readbyqxmd.com/read/28157409/external-factors-that-influence-the-practice-of-radiology-proceedings-of-the-international-society-for-strategic-studies-in-radiology-meeting
#17
Geoffrey D Rubin, Barbara J McNeil, András Palkó, James H Thrall, Gabriel P Krestin, Ada Muellner, Herbert Y Kressel
In both the United States and Europe, efforts to reduce soaring health care costs have led to intense scrutiny of both standard and innovative uses of imaging. Given that the United States spends a larger share of its gross domestic product on health care than any other nation and also has the most varied health care financing and delivery systems in the world, it has become an especially fertile environment for developing and testing approaches to controlling health care costs and value. This report focuses on recent reforms that have had a dampening effect on imaging use in the United States and provides a glimpse of obstacles that imaging practices may soon face or are already facing in other countries...
February 4, 2017: Radiology
https://www.readbyqxmd.com/read/28153620/potential-and-limitations-of-neural-decompression-in-extreme-lateral-interbody-fusion-a-systematic-review
#18
REVIEW
Gernot Lang, Moritz Perrech, Rodrigo Navarro-Ramirez, Ibrahim Hussain, Brenton Pennicooke, Farah Maryam, Mauricio J Avila, Roger Hartl
BACKGROUND: Extreme lateral interbody fusion (ELIF) is a powerful tool for interbody fusion and coronal deformity correction. However, evidence regarding the success of ELIF in decompressing foraminal, lateral recesses and central canal stenosis is lacking. The purpose of this study was to systematically review current literature on the potential and limitations of ELIF to indirectly decompress neural elements. METHODS: A systematic literature search in the PubMed, Cochrane and ScienceDirect databases was performed according to PRISM criteria...
January 30, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28152155/bullying-in-senior-living-facilities-perspectives-of-long-term-care-staff
#19
Felicia J Andresen, Jeffrey A Buchanan
HOW TO OBTAIN CONTACT HOURS BY READING THIS ARTICLE INSTRUCTIONS XX contact hours will be awarded by Villanova University College of Nursing upon successful completion of this activity. A contact hour is a unit of measurement that denotes 60 minutes of an organized learning activity. This is a learner-based activity. Villanova University College of Nursing does not require submission of your answers to the quiz. A contact hour certificate will be awarded once you register, pay the registration fee, and complete the evaluation form online at http://goo...
February 2, 2017: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/28152153/aspects-of-self-and-identity-in-narrations-about-recent-events-communication-with-individuals-with-alzheimer-s-disease-enabled-by-a-digital-photograph-diary
#20
Eva Karlsson, Karin Zingmark, Karin Axelsson, Stefan Sävenstedt
HOW TO OBTAIN CONTACT HOURS BY READING THIS ARTICLE INSTRUCTIONS XX contact hours will be awarded by Villanova University College of Nursing upon successful completion of this activity. A contact hour is a unit of measurement that denotes 60 minutes of an organized learning activity. This is a learner-based activity. Villanova University College of Nursing does not require submission of your answers to the quiz. A contact hour certificate will be awarded once you register, pay the registration fee, and complete the evaluation form online at http://goo...
February 2, 2017: Journal of Gerontological Nursing
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