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https://www.readbyqxmd.com/read/29792994/lumbar-spinal-stenosis-comparison-of-surgical-practice-variation-and-clinical-outcome-in-three-national-spine-registries
#1
Greger Lønne, Peter Fritzell, Olle Hägg, Dennis Nordvall, Paul Gerdhem, Tobias Lagerbäck, Mikkel Andersen, Søren Eiskjaer, Martin Gehrchen, Wilco Jacobs, Miranda L van Hooff, Tore K Solberg
BACKGROUND: Decompression surgery for lumbar spinal stenosis (LSS) is the most common spinal procedure in the elderly. To avoid persisting low back pain, adding arthrodesis has been recommended, especially if there is a coexisting degenerative spondylolisthesis. However, this strategy remains controversial, resulting in practice-based variation. PURPOSE: To evaluate in a pragmatic study if surgical selection criteria and variation in use of arthrodesis in three Scandinavian countries can be linked to variation in treatment effectiveness...
May 21, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29792993/responsiveness-of-the-japanese-orthopaedic-association-back-pain-evaluation-questionnaire-in-lumbar-surgery-and-its-threshold-for-indicating-clinically-important-differences
#2
Takahito Fujimori, Toshitada Miwa, Takenori Oda
BACKGROUND CONTEXT: Introduced in 2007, the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ) has been widely used, but its psychometric properties have not been well studied. PURPOSE: To assess the responsiveness and the clinically important differences of JOABPEQ for lumbar surgery. STUDY DESIGN: Prospective study. PATIENT SAMPLE: Two hundreds and three consecutive patients underwent lumbar surgeries between July 2013 and November 2015 in a single hospital...
May 21, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29792080/stakeholders-resistance-to-telemedicine-with-focus-on-physicians-utilizing-the-delphi-technique
#3
Woo Seok Choi, Joowoong Park, Jin Young Brian Choi, Jae-Suk Yang
Introduction Sufficient infrastructure for information and communications technology (ICT) and a well-established policy are necessary factors for smooth implementation of telemedicine. However, despite these necessary conditions being met, there are situations where telemedicine still fails to be accepted as a system due to the low receptivity of stakeholders. In this study, we analyse stakeholders' resistance to an organization's implementation of telemedicine. Focusing on the physicians' interests, we propose a strategy to minimize conflicts and improve acceptance...
January 1, 2018: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/29791757/organ-donation-after-euthanasia-morally-acceptable-under-strict-procedural-safeguards
#4
Gert van Dijk, Rozemarijn van Bruchem-Visser, Inez de Beaufort
In this paper, we will present a case of organ donation after active euthanasia (ODE) in The Netherlands from a patient who had his life ended at his explicit and voluntary request. The form of ODE we describe here concerns patients who are not unconscious and on life support, but who are conscious and want to have their life ended because of their hopeless and unbearable suffering, for instance due to a terminal illness such as Amyotrophic Lateral Sclerosis (ALS) or Multiple Sclerosis (MS). This form of ODE is of course only possible in jurisdictions where euthanasia is allowed...
May 23, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29789652/small-hypoxia-primed-mesenchymal-stem-cells-attenuate-graft-versus-host-disease
#5
YongHwan Kim, Hye Jin Jin, Jinbeom Heo, Hyein Ju, Hye-Yeon Lee, Sujin Kim, Seungun Lee, Jisun Lim, Sang Young Jeong, JiHye Kwon, Miyeon Kim, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Hyun Ho Hwang, Hwan Yeul Yu, Chae-Min Ryu, Hong Bae Jeon, Dong-Myung Shin
Mesenchymal stem cells (MSCs) are of particular interest for the treatment of immune-related diseases due to their immunosuppressive capacity. Here, we show that Small MSCs primed with Hypoxia and Calcium ions (SHC-MSCs) exhibit enhanced stemness and immunomodulatory functions for treating allogeneic conflicts. Compared with naïve cultured human umbilical cord blood-derived MSCs, SHC-MSCs were resistant to passage-dependent senescence mediated via the monocyte chemoattractant protein-1 and p53/p21 cascade and secreted large amounts of pro-angiogenic and immunomodulatory factors, resulting in suppression of T-cell proliferation...
May 22, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29788389/pregnancy-after-vasectomy-surgical-reversal-or-assisted-reproduction
#6
U Valerie, S De Brucker, M De Brucker, V Vloeberghs, P Drakopoulos, S Santos-Ribeiro, H Tournaye
STUDY QUESTION: Should we opt for surgical vasovasostomy or IVF/ICSI after a vasectomy? SUMMARY ANSWER: Both options reveal acceptable pregnancy rates though the time to pregnancy was significantly lower in the immediate IVF/ICSI group. WHAT IS KNOWN ALREADY: About 7.4% of men regret their vasectomy and express a renewed child wish. The choice between surgical vasectomy reversal or ICSI remains difficult for patients and their fertility specialist...
May 17, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29788136/an-experimental-evaluation-of-the-benefits-and-costs-of-providing-fertility-information-to-adolescents-and-emerging-adults
#7
J Boivin, E Koert, T Harris, L O'Shea, A Perryman, K Parker, C Harrison
STUDY QUESTION: Does the provision of fertility (compared to control) information affect fertility-related knowledge, perceived threat of infertility, anxiety, physical stress and fertility plans in adolescents and emerging adults? SUMMARY ANSWER: The provision of fertility information was associated with increased fertility knowledge (emerging adults) and greater infertility threat (adolescents and emerging adults). WHAT IS KNOWN ALREADY: According to fertility education research, adolescents and emerging adults know less than they should know about fertility topics...
May 17, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29787408/organ-donation-after-circulatory-death-ethical-issues-and-international-practices
#8
Barbara G Jericho
Donation after circulatory death (DCD) is an increasingly utilized practice that can contribute to reducing the difference between the supply of organs and the demand for organs for transplantation. As the number of transplanted organs from DCD donors continues to increase, there is an essential need to address the ethical aspects of DCD in institutional DCD protocols and clinical practice. Ethical issues of respecting the end-of-life wishes of a potential donor, respecting a recipient's wishes, and addressing potential conflicts of interest are important considerations in developing policies and procedures for DCD programs...
May 21, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29785289/what-is-the-role-of-wedge-resection-for-t1a-lung-cancer
#9
Sebron Harrison, Brendon Stiles, Nasser Altorki
Since 1995, lobar resection became the standard of care for medically fit patients with early stage lung cancer. This was based on the results of a single randomized trial comparing lobectomy and sublobar resection (SLR) in stage I lung cancer conducted by the lung cancer study group between 1982 and 1988. The conclusions of the study included a statistically significant tripling in loco-regional recurrence (LR) after limited resection but no difference between the two arms of the trial in systemic recurrence...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29782586/reflective-practices-at-the-security-council-children-and-armed-conflict-and-the-three-united-nations
#10
Ingvild Bode
The United Nations Security Council passed its first resolution on children in armed conflict in 1999, making it one of the oldest examples of Security Council engagement with a thematic mandate and leading to the creation of a dedicated working group in 2005. Existing theoretical accounts of the Security Council cannot account for the developing substance of the children and armed conflict agenda as they are macro-oriented and focus exclusively on states. I argue that Security Council decision-making on thematic mandates is a productive process whose outcomes are created by and through practices of actors across the three United Nations: member states (the first United Nations), United Nations officials (the second United Nations) and non-governmental organizations (the third United Nations)...
June 2018: European journal of international relations
https://www.readbyqxmd.com/read/29779808/is-multi-level-marketing-of-nutrition-supplements-a-legal-and-an-ethical-practice
#11
Diana Cardenas, Vanessa Fuchs-Tarlovsky
BACKGROUND: Multi-level marketing (MLM) of nutrition products has experienced dramatic growth in recent decades. 'Wellness' is the second most popular niche in the MLM industry and represents 35% of sales among all the products in 2016. This category includes dietary supplements, weight management and sports nutrition products. The aim of this paper is to analyse whether this practice is legal and ethical. METHODS: An analysis of available documentary information about the legal aspects of Multi-level marketing business was performed...
June 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29776690/misconduct-as-the-main-cause-for-retraction-a-descriptive-study-of-retracted-publications-and-their-authors
#12
Isabel Campos-Varela, Alberto Ruano-Raviña
OBJECTIVE: To analyze the causes of retracted publications and the main characteristics of their authors. METHOD: A descriptive cross-sectional study was designed including all retracted publications from January 1st, 2013-December 31st, 2016 indexed in PubMed. The causes of retraction were classified as: data management, authorship issues, plagiarism, unethical research, journal issues, review process, conflict of interest, other causes, and unknown reasons. Then, misbehaviour was classified as misconduct, suspicion of misconduct or no misconduct suspicion...
May 15, 2018: Gaceta Sanitaria
https://www.readbyqxmd.com/read/29776538/rapid-detection-of-calr-type-1-and-type-2-mutations-using-pna-lna-clamping-loop-mediated-isothermal-amplification-on-a-cd-like-microfluidic-chip
#13
Guojun Cao, Jilie Kong, Zhifang Xing, Yigui Tang, Xinju Zhang, Xiao Xu, Zhihua Kang, Xueen Fang, Ming Guan
Bleeding and thrombosis represent common complications in myeloproliferative neoplasms (MPN) and significantly contribute to morbidity and mortality. Molecular markers, including CALR mutations, were considered not only as diagnostic markers, but also as risk factors for bleeding and thrombosis associated with MPN, especially for patients in remote primary hospitals. We sought to develop an easy-to-use assay for the rapid detection of CALR type 1 (CALR-1) and type 2 (CALR-2) mutations in Philadelphia chromosome-negative MPN patients...
September 18, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29775468/conflicts-of-interest-of-editors-of-medical-journals
#14
Waqas Haque, Abu Minhajuddin, Arjun Gupta, Deepak Agrawal
BACKGROUND: Almost all medical journals now require authors to publicly disclose conflicts of interests (COI). The same standard and scrutiny is rarely employed for the editors of the journals although COI may affect editorial decisions. METHODS: We conducted a retrospective observational study to determine the prevalence and magnitude of financial relationships among editors of 60 influential US medical journals (10 each for internal medicine and five subspecialties: cardiology, gastroenterology, neurology, dermatology and allergy & immunology)...
2018: PloS One
https://www.readbyqxmd.com/read/29773889/searching-for-a-compromise-between-biological-and-economic-demands-to-protect-vulnerable-habitats
#15
M Grazia Pennino, Marie-Christine Rufener, Mario J F Thomé-Souza, Adriana R Carvalho, Priscila F M Lopes, U Rashid Sumaila
Identifying vulnerable habitats is necessary to designing and prioritizing efficient marine protected areas (MPAs) to sustain the renewal of living marine resources. However, vulnerable habitats rarely become MPAs due to conflicting interests such as fishing. We propose a spatial framework to help researchers and managers determine optimal conservation areas in a multi-species fishery, while also considering the economic relevance these species may have in a given society, even in data poor situations. We first set different ecological criteria (i...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29764522/treatment-resistant-depression-and-peripheral-c-reactive-protein
#16
Samuel R Chamberlain, Jonathan Cavanagh, Peter de Boer, Valeria Mondelli, Declan N C Jones, Wayne C Drevets, Philip J Cowen, Neil A Harrison, Linda Pointon, Carmine M Pariante, Edward T Bullmore
BACKGROUND: C-reactive protein (CRP) is a candidate biomarker for major depressive disorder (MDD), but it is unclear how peripheral CRP levels relate to the heterogeneous clinical phenotypes of the disorder.AimTo explore CRP in MDD and its phenotypic associations. METHOD: We recruited 102 treatment-resistant patients with MDD currently experiencing depression, 48 treatment-responsive patients with MDD not currently experiencing depression, 48 patients with depression who were not receiving medication and 54 healthy volunteers...
May 16, 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29760768/mechanisms-of-change-for-interventions-aimed-at-improving-the-wellbeing-mental-health-and-resilience-of-children-and-adolescents-affected-by-war-and-armed-conflict-a-systematic-review-of-reviews
#17
REVIEW
Tania Josiane Bosqui, Bassam Marshoud
Despite increasing research and clinical interest in delivering psychosocial interventions for children affected by war, little research has been conducted on the underlying mechanisms of change associated with these interventions. This review aimed to identify these processes in order to inform existing interventions and highlight research gaps. A systematic review of reviews was conducted drawing from academic databases (PubMed, PILOTS, Cochrane Library for Systematic Reviews) and field resources (e.g. Médecins Sans Frontières and the Psychosocial Centre of the International Federation of Red Cross and Red Crescent Societies), with extracted data analysed using Thematic Content Analysis...
2018: Conflict and Health
https://www.readbyqxmd.com/read/29760253/deprescribing-benzodiazepine-receptor-agonists-evidence-based-clinical-practice-guideline
#18
Kevin Pottie, Wade Thompson, Simon Davies, Jean Grenier, Cheryl A Sadowski, Vivian Welch, Anne Holbrook, Cynthia Boyd, Robert Swenson, Andy Ma, Barbara Farrell
OBJECTIVE: To develop an evidence-based guideline to help clinicians make decisions about when and how to safely taper and stop benzodiazepine receptor agonists (BZRAs); to focus on the highest level of evidence available and seek input from primary care professionals in the guideline development, review, and endorsement processes. METHODS: The overall team comprised 8 clinicians (1 family physician, 2 psychiatrists, 1 clinical psychologist, 1 clinical pharmacologist, 2 clinical pharmacists, and 1 geriatrician) and a methodologist; members disclosed conflicts of interest...
May 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29759077/regulating-pharmaceutical-companies-financial-largesse
#19
REVIEW
Ronen Avraham, Charles Silver
Nissanholtz-Gannot and Yenkellevich (NGY) explore the impact of a 2010 amendment to the Israeli National Health Insurance Law that requires annual reporting of payments from pharmaceutical companies (PCs) to doctors and healthcare organizations. The amendment was adopted to ensure transparency and to facilitate appropriate regulation of interest conflicts. To learn whether the amendment was having the desired effects, NGY interviewed multiple representatives of an assortment of stakeholders. They found broad agreement among the respondents that financial relationships between PCs and physicians should be transparent...
May 14, 2018: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/29757751/expression-of-editorial-concern-correction-of-conflict-of-interest-and-affiliation
#20
Jmir Editorial Office
[This corrects the article DOI: 10.2196/resprot.7993.].
May 14, 2018: JMIR Research Protocols
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