Lizette Utomo, Susanne M Eijgenraam, Duncan E Meuffels, Sita M A Bierma-Zeinstra, Yvonne M Bastiaansen-Jenniskens, Gerjo J V M van Osch
Meniscal damage is, despite its major role in knee osteoarthritis (OA), often neglected in OA animal models. We evaluated structural meniscal degeneration during the course of OA in the murine collagenase-induced OA (CIOA) model. To investigate this, OA was induced in the knee joints of 33 male C57BL/6 mice by an intra-articular injection of 10U collagenase. The mice were sacrificed after 1, 3, 7, 14, 28, and 56 days, and the knees were harvested and processed for histological analysis. As control, 6 knees were obtained from 16-week-old mice in which no OA was induced...
April 6, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society