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Knee meniscus

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https://www.readbyqxmd.com/read/27911285/the-relation-between-chondromalacia-patella-and-meniscal-tear-and-the-sulcus-angle-trochlear-depth-ratio-as-a-powerful-predictor
#1
Hatice Resorlu, Coskun Zateri, Gurdal Nusran, Ferdi Goksel, Nilufer Aylanc
PURPOSE: To investigate the relation between chondromalacia patella and the sulcus angle/trochlear depth ratio as a marker of trochlear morphology. In addition, we also planned to show the relationship between meniscus damage, subcutaneous adipose tissue thickness as a marker of obesity, patellar tilt angle and chondromalacia patella. METHODS: Patients with trauma, rheumatologic disease, a history of knee surgery and patellar variations such as patella alba and patella baja were excluded...
November 25, 2016: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/27909660/osteochondral-proximal-tibial-and-lateral-meniscal-allograft-transplant
#2
Guillem Gonzalez-Lomas, Andrew P Dold, Daniel J Kaplan, David J Fralinger, Laith Jazrawi
Knee pain in young, active patients with meniscus-deficient knees and articular cartilage damage can present a challenge to treatment. Meniscal allograft transplantation (MAT) has shown good clinical results as treatment for meniscus deficiency; however, worse outcomes have been observed in patients with significant chondral damage. The development of chondral restorative techniques such as osteochondral allograft transplantation (OCA) has expanded the population of patients who may benefit from MAT. We present a case of proximal tibial osteochondral and lateral meniscal allograft transplant...
October 2016: Arthroscopy Techniques
https://www.readbyqxmd.com/read/27904597/where-does-magnetic-resonance-imaging-stand-in-the-diagnosis-of-knee-injuries
#3
Shirvan Rastegar, Mahdi Motififard, Amin Nemati, Naeime-Sadat Hosseini, Mohammad Ali Tahririan, Sayyed Alireza Rozati, Mahdi Sepiani, Mehdi Moezi
BACKGROUND: The aim of this study was to determine the diagnostic value of magnetic resonance imaging (MRI) in the diagnosis of knee injuries. MATERIALS AND METHODS: Ninety-eight consecutive patients were enrolled in the study. In all patients, MRI and arthroscopy were performed and the results were compared. RESULTS: MRI was most sensitive in the detection of medial meniscus injuries, and the highest specificity and negative predictive value (NPV) were found in the detection of posterior cruciate ligament injuries...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27897156/quantitative-evaluation-of-the-mechanical-risks-caused-by-focal-cartilage-defects-in-the-knee
#4
Mikko S Venäläinen, Mika E Mononen, Jari Salo, Lasse P Räsänen, Jukka S Jurvelin, Juha Töyräs, Tuomas Virén, Rami K Korhonen
Focal cartilage lesions can proceed to severe osteoarthritis or remain unaltered even for years. A method to identify high risk defects would be of utmost importance to guide clinical decision making and to identify the patients that are at the highest risk for the onset and progression of osteoarthritis. Based on cone beam computed tomography arthrography, we present a novel computational model for evaluating changes in local mechanical responses around cartilage defects. Our model, based on data obtained from a human knee in vivo, demonstrated that the most substantial alterations around the defect, as compared to the intact tissue, were observed in minimum principal (compressive) strains and shear strains...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27895039/region-specific-effect-of-the-decellularized-meniscus-extracellular-matrix-on-mesenchymal-stem-cell-based-meniscus-tissue-engineering
#5
Kazunori Shimomura, Benjamin B Rothrauff, Rocky S Tuan
BACKGROUND: The meniscus is the most commonly injured knee structure, and surgical repair is often ineffective. Tissue engineering-based repair or regeneration may provide a needed solution. Decellularized, tissue-derived extracellular matrices (ECMs) have received attention for their potential use as tissue-engineered scaffolds. In considering meniscus-derived ECMs (mECMs) for meniscus tissue engineering, it is noteworthy that the inner and outer regions of the meniscus have different structural and biochemical features, potentially directing the differentiation of cells toward region-specific phenotypes...
November 28, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27887880/anamnestic-prediction-of-bucket-handle-compared-to-other-tear-patterns-of-the-medial-meniscus-in-stable-knees
#6
Barak Haviv, Shlomo Bronak, Yona Kosashvili, Rafael Thein
OBJECTIVE: The aim of this study was to analyze and compare the preoperative anamnestic details between patients with an arthroscopic diagnosis of bucket handle and other tear patterns of the medial meniscus in stable knees. METHODS: A total of 204 patients (mean age 49.3 ± 13 years) were included in the study. The mean age was 49.3 ± 13 years. The study group included 65 patients (63 males, 2 females) with an arthroscopic diagnosis of bucket handle tear and the control group included 139 patients (90 males, 49 females) with non-bucket handle tear patterns...
November 23, 2016: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/27885289/assessment-of-knee-joint-injuries-with-low-field-strength-magnetic-resonance-imaging
#7
O B Panta, N P Neupane, S Songmen, G Gurung
BACKGROUND: Magnetic Resonance Imaging is an appropriate screening tool before therapeutic arthroscopy, making diagnostic arthroscopy unnecessary in most patients. This study aims to evaluate the MRI findings in knee injuries and diagnostic value of low Strength MRI for assessing Meniscal and cruciate ligament tear. METHODS: A cross sectional study was conducted on patients undergoing "Magnetic Resonance Imaging of the Knee" for injuries of the knee and excluded patients undergoing MRI for other causes, poor diagnostic quality MRI and post operative MRI...
May 2016: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/27880969/the-prevalence-of-cruciate-ligament-and-meniscus-knee-injury-in-young-adults-and-associations-with-gender-body-mass-index-and-height-a-large-cross-sectional-study
#8
Ran Thein, Oded Hershkovich, Barak Gordon, Gideon Burstein, Shay Tenebaum, Estela Derazne, Dorit Tzur, Ari Shamis, Arnon Afek, Yitshak Kreiss
Anterior cruciate ligament and meniscal injuries are associated with secondary osteoarthrosis which may lead to functional impairment and economic burden. The prevalence of knee injury has not been studied in depth. Our purpose was to report the prevalence of knee ligament and meniscal injuries and their associations with gender, body mass index (BMI), and height in young adults and to characterize individuals with meniscal injuries who gained full recovery. A cross-sectional, population-based study was conducted...
November 23, 2016: Journal of Knee Surgery
https://www.readbyqxmd.com/read/27878340/anatomical-risk-evaluation-of-iatrogenic-injury-to-the-infrapatellar-branch-of-the-saphenous-nerve-during-medial-meniscus-arthroscopic-surgery
#9
Guillaume Koch, Agathe Kling, Nitin Ramamurthy, Faramarz Edalat, Roberto Luigi Cazzato, Jean-Luc Kahn, Julien Garnon, Philippe Clavert
PURPOSE: To determine the relationship of the medial meniscus with the infrapatellar branches of the saphenous nerve, the primary goal is to define and characterize different risk areas for these nerves during medial meniscus surgery. METHODS: After dissecting 20 embalmed cadaver knees, we defined 7 readily identifiable anatomical landmarks. For each knee, we recorded 2 morphological criteria and 16 measurements. RESULTS: The most common anatomical course is a main trunk that is 8 mm anterior to the tuberculum adductorium and 60 mm posterior to the midpoint of the medial patellar margin...
November 22, 2016: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/27876676/anatomical-region-dependent-enhancement-of-3-dimensional-chondrogenic-differentiation-of-human-mesenchymal-stem-cells-by-soluble-meniscus-extracellular-matrix
#10
Benjamin B Rothrauff, Kazunori Shimomura, Riccardo Gottardi, Peter G Alexander, Rocky S Tuan
: Extracellular matrix (ECM) derived from decellularized tissues has been found to promote tissue neogenesis, most likely mediated by specific biochemical and physical signaling motifs that promote tissue-specific differentiation of progenitor cells. Decellularized ECM has been suggested to be efficacious for the repair of tissue injuries. However, decellularized meniscus contains a dense collagenous structure, which impedes cell seeding and infiltration and is not readily applicable for meniscus repair...
November 19, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27869622/acl-deficiency-increases-forces-on-the-medial-femoral-condyle-and-the-lateral-meniscus-with-applied-rotatory-loads
#11
Lucas S McDonald, James Boorman-Padgett, Robert Kent, Kyle Stone, Thomas L Wickiewicz, Andrew D Pearle, Carl W Imhauser
BACKGROUND: The articular surfaces and menisci act with the anterior cruciate ligament (ACL) to stabilize the knee joint. Their role in resisting applied rotatory loads characteristic of instability events is unclear despite commonly observed damage to these intra-articular structures in the acute and chronic ACL injury settings. METHODS: Ten fresh-frozen human cadaveric knees were mounted to a robotic manipulator. Combined valgus and internal rotation torques were applied in the presence and absence of a 300-N compressive load...
October 19, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27849504/return-to-duty-rates-following-meniscal-repair-surgery-in-an-active-duty-military-population
#12
Joseph W Galvin, Chase A Dukes, Jason A Grassbaugh, Bryant G Marchant, Edward D Arrington
Meniscal injury is a common knee injury in a young athletic population. Maintaining the integrity of the meniscus is critical to reducing contact pressures on the tibiofemoral articulation. The purpose of this study is to analyze the outcomes of meniscal repair in a young military population. We conducted a retrospective review of all meniscal repairs performed on active duty Army personnel at a Military Medical Center from January 2002 to December 2012. One hundred seventy-eight active duty patients, mean age 28 (19-48) years underwent 178 meniscal repairs...
November 2016: Military Medicine
https://www.readbyqxmd.com/read/27847860/morphology-of-anterolateral-ligament-of-the-knee-a-cadaveric-observation-with-clinical-insight
#13
Bhagath Kumar Potu, Abdel Halim Salem, Marwan F Abu-Hijleh
Background. The morphology and function of anterolateral ligament (ALL) of the knee are not clearly understood even today with all the sophisticated techniques available. There have been differing descriptions of the ALL of the knee in literature, and not all of them have been named or described clearly. Aim. The present study was undertaken to provide a clear structure/relationship description on ALL. Materials and Methods. We used 24 formalin-fixed cadaveric limbs. Knee regions of the all the limbs were neatly dissected and the ALL was exposed...
2016: Advances in Medicine
https://www.readbyqxmd.com/read/27836674/chondroprotective-activity-of-n-acetyl-phenylalanine-glucosamine-derivative-on-knee-joint-structure-and-inflammation-in-a-murine-model-of-osteoarthritis
#14
F Veronesi, G Giavaresi, M Maglio, A Scotto d'Abusco, L Politi, R Scandurra, E Olivotto, B Grigolo, R M Borzì, M Fini
OBJECTIVE: Osteoarthritis (OA), the most common chronic degenerative joint disease, is characterized by joint structure changes and inflammation, both mediated by the IκB kinase (IKK) signalosome complex. The ability of N-acetyl phenylalanine derivative (NAPA) to increase cartilage matrix components and to reduce inflammatory cytokines, inhibiting IKKα kinase activity, has been observed in vitro. The present study aims to further clarify the effect of NAPA in counteracting OA progression, in an in vivo mouse model after destabilization of the medial meniscus (DMM)...
November 9, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27824675/-fat-brook-in-the-popliteal-fossa-cadaveric-and-clinical-investigation-with-magnetic-resonance-imaging
#15
Yoonah Song, Seunghun Lee, Doo-Jin Paik, Jiyoon Bae
OBJECTIVE: This study aimed to describe the "fat brook" (FB) in the popliteal fossa of a cadaver and to evaluate its clinical significance. METHODS: Ten fresh cadaveric knees underwent magnetic resonance imaging and histologic analyses. In addition, magnetic resonance imaging images from 321 patients (108 men, 213 women; mean age, 49.8 years; age range, 5-92 years) were retrospectively reviewed. Two radiologists independently determined the presence/absence of the FB and internal derangement of the knee...
November 7, 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27824492/evolution-of-intrameniscal-signal-intensity-alterations-detected-on-mri-over-24-months-in-patients-with-traumatic-anterior-cruciate-ligament-tear
#16
Julio Brandao Guimaraes, Luca Facchetti, Benedikt J Schwaiger, Alexandra S Gersing, Sharmila Majumdar, Benjamin C Ma, Xiaojuan Li, Thomas M Link
OBJECTIVE: The objective of our study was to assess the prevalence and evolution of intrameniscal signal-intensity alteration in subjects with an anterior cruciate ligament (ACL) tear over 24 months and compare clinical outcome and changes of cartilage between subjects with and those without this meniscal abnormality. MATERIALS AND METHODS: Fifty-seven subjects with an ACL tear were screened for intrameniscal signal-intensity alteration. Morphologic and compositional MRI was performed before ACL reconstruction and 12 and 24 months after ACL reconstruction...
November 8, 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27816090/can-we-trust-knee-meniscus-studies-one-way-crossover-confounds-intent-to-treat-statistical-methods
#17
EDITORIAL
James H Lubowitz, Ralph B D'Agostino, Matthew T Provencher, Michael J Rossi, Jefferson C Brand
Randomized controlled studies have a high level of evidence. However, some patients are not treated in the manner to which they were randomized and actually switch to the alternative treatment (crossover). In such cases, "intent-to-treat" statistical methods require that such a switch be ignored, resulting in bias. Thus, the study conclusions could be wrong. This bias is a common problem in the knee meniscus literature.
November 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27813662/matrix-metalloproteinase-activity-and-prostaglandin-e2-are-elevated-in-the-synovial-fluid-of-meniscus-tear-patients
#18
Betty Liu, Adam P Goode, Teralyn E Carter, Gangadhar M Utturkar, Janet L Huebner, Dean C Taylor, Claude T Moorman Iii, William E Garrett, Virginia B Kraus, Farshid Guilak, Louis E DeFrate, Amy L McNulty
PURPOSE: Meniscus tears are a common knee injury and are associated with the development of post-traumatic osteoarthritis (OA). The purpose of this study was to evaluate potential OA mediators in the synovial fluid and serum of meniscus tear subjects compared to those in the synovial fluid of radiographic non-OA control knees. MATERIALS AND METHODS: Sixteen subjects with an isolated unilateral meniscus injury and six subjects who served as reference controls (knee Kellgren-Lawrence grade 0-1) were recruited...
November 4, 2016: Connective Tissue Research
https://www.readbyqxmd.com/read/27813166/characteristics-of-meniscus-progenitor-cells-migrated-from-injured-meniscus
#19
Dongrim Seol, Cheng Zhou, Marc J Brouillette, Ino Song, Yin Yu, Hyeong Hun Choe, Abigail D Lehman, Kee W Jang, Douglas C Fredericks, Barbara J Laughlin, James A Martin
Serious meniscus injuries seldom heal and increase the risk for knee osteoarthritis; thus, there is a need to develop new reparative therapies. In that regard, stimulating tissue regeneration by autologous stem/progenitor cells has emerged as a promising new strategy. We showed previously that migratory chondrogenic progenitor cells (CPCs) were recruited to injured cartilage, where they showed a capability in situ tissue repair. Here, we tested the hypothesis that the meniscus contains a similar population of regenerative cells...
November 3, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27808352/suppression-of-cartilage-degeneration-by-intra-articular-injection-of-heparan-sulfate-6-o-endosulfatase-in-a-mouse-osteoarthritis-model
#20
Shuhei Otsuki, Tomohiko Murakami, Yoshinori Okamoto, Yoshiaki Hoshiyama, Shuhei Oda, Masashi Neo
We previously reported that heparan sulfate 6-O endosulfatases (Sulfs) were expressed in articular cartilage, and that the Sulf-1 knockout mouse developed severe knee osteoarthritis. In this study, we hypothesised that intra-articular injection of Sulf-1 would prevent cartilage degeneration. After confirming that 1 mg/ml Sulf-1 did not induce ATDC5 cell death in vitro, gene expression of type II collagen and matrix metalloproteinase (MMP)-13 in the presence of Sulf-1 (1 100 ng/ml) were determined by quantitative real-time polymerase chain reaction...
November 3, 2016: Histology and Histopathology
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