keyword
https://read.qxmd.com/read/38536534/serial-daily-lactate-levels-association-with-30-day-outcome-in-cardiogenic-shock-patients-treated-with-va-ecmo-a-post-hoc-analysis-of-the-hypo-ecmo-study
#1
JOURNAL ARTICLE
Bruno Levy, Nicolas Girerd, Guillaume Baudry, Kevin Duarte, Samuel Cuau, Jan Bakker, Antoine Kimmoun
BACKGROUND: Reliable predictors of outcomes in venoarterial extracorporeal membrane oxygenation (VA-ECMO) therapy are limited. While elevated lactate levels over time have been linked to outcomes in cardiogenic shock (CS), their significance in VA-ECMO-treated patients remains inconclusive. METHODS: We conducted a post hoc analysis of data from the HYPO-ECMO trial, which compared normothermia to moderate hypothermia in CS patients supported by VA-ECMO. We examined daily lactate levels collected over a week to assess their correlation with 30-day mortality...
March 27, 2024: Annals of Intensive Care
https://read.qxmd.com/read/38534490/deep-learning-for-generalized-eeg-seizure-detection-after-hypoxia-ischemia-preclinical-validation
#2
JOURNAL ARTICLE
Hamid Abbasi, Joanne O Davidson, Simerdeep K Dhillon, Kelly Q Zhou, Guido Wassink, Alistair J Gunn, Laura Bennet
Brain maturity and many clinical treatments such as therapeutic hypothermia (TH) can significantly influence the morphology of neonatal EEG seizures after hypoxia-ischemia (HI), and so there is a need for generalized automatic seizure identification. This study validates efficacy of advanced deep-learning pattern classifiers based on a convolutional neural network (CNN) for seizure detection after HI in fetal sheep and determines the effects of maturation and brain cooling on their accuracy. The cohorts included HI-normothermia term ( n = 7), HI-hypothermia term ( n = 14), sham-normothermia term ( n = 5), and HI-normothermia preterm ( n = 14) groups, with a total of >17,300 h of recordings...
February 24, 2024: Bioengineering
https://read.qxmd.com/read/38531575/survival-and-neurological-function-in-patients-treated-with-extracorporeal-membrane-oxygenation-and-therapeutic-hypothermia-a-protocol-for-updating-a-systematic-review
#3
JOURNAL ARTICLE
Pengfei Cheng, Haizhen Wang, Luyao Guo, Meiling Wang, He Xu, Peipei Gu, Jinjing Wu, Minfei Yang
INTRODUCTION: The widespread application of extracorporeal membrane oxygenation (ECMO) has enhanced clinical outcomes for patients experiencing cardiac arrest. However, its effectiveness is still limited and falls short of the desired level. Therapeutic hypothermia, which maintains body temperatures between 32°C and 36°C in cardiac arrest patients treated with ECMO, has been proposed as a potential means of neuroprotection and increased survival rates. Nevertheless, it remains controversial, and its impact on patient complications has yet to be fully understood...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38529441/prehospital-cervical-spine-c-spine-stabilization-and-airway-management-in-a-trauma-patient-a-review
#4
REVIEW
Utkarsh M Waghmare, Akhilesh Singh
Severe traumatic damage to the brain-to-body signaling bundle that results in bruising and a partial or total tear of the spinal cord is known as a spinal cord injury (SCI). SCI may develop at the time of an event or after. It can also develop while handling the patient and can worsen during the transportation of the patient. So prehospital care is crucial to prevent or minimize SCI. Prehospital care involves examining the patient, immobilizing the cervical spine (C-spine), providing cardiovascular support (keeping the mean arterial blood pressure over 85 mmHg), and carefully managing the airway (possibly intubating the patient using manual in-line stabilization (MILS))...
February 2024: Curēus
https://read.qxmd.com/read/38528868/a-real-time-biphasic-kalman-filter-based-model-for-estimating-human-core-temperature-from-heart-rate-measurements-for-application-in-the-occupational-field
#5
JOURNAL ARTICLE
Tiziana Falcone, Simona Del Ferraro, Vincenzo Molinaro, Loredana Zollo, Paolo Lenzuni
INTRODUCTION: Early identification of hypothermia or hyperthermia is of vital importance, and real-time monitoring of core temperature ( CT ) of the workers exposed to thermal environments is an extremely valuable tool. From the existing literature studies, the model developed by Buller et al. in their study of 2013 that generates real-time estimates of CT from heart rate ( HR ) measurements using the Kalman filter (KF) shows good potential for occupational application. However, some aspects could be improved to reliably handle the existing very wide range of workers and work activities...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38526704/effect-of-chronic-cold-stress-on-gut-microbial-diversity-intestinal-inflammation-and-pyroptosis-in-mice
#6
JOURNAL ARTICLE
Hongming Lv, Shijie Xia, Yuxi He, Chunyu Qiao, Jiahe Liu, Jingru Guo, Shize Li
Hypothermia is an essential environmental factor in gastrointestinal diseases, but the main molecular mechanisms of pathogenesis remain unclear. The current study sought to better understand how chronic cold stress affects gut damage and its underlying mechanisms. In this work, to establish chronic cold stress (CS)-induced intestinal injury model, mice were subjected to continuous cold exposure (4 °C) for 3 h per day for 3 weeks. Our results indicated that CS led to gut injury via inducing changes of heat shock proteins 70 (HSP70) and apoptosis-related (caspases-3, Bax and Bcl-2) proteins; enhancing expression of intestinal tight-related (ZO-1 and occludin) proteins; promoting releases of inducible nitric oxide synthase (iNOS), tumor necrosis factor-α (TNF-α), cyclooxygenase-2 (COX-2), high mobility group box 1 (HMGB1), interleukin1β (IL-1β), IL-18 and IL-6 inflammatory mediators in the ileum; and altering gut microbial diversity...
March 25, 2024: Journal of Physiology and Biochemistry
https://read.qxmd.com/read/38526135/sirt3-mediates-the-cardioprotective-effect-of-therapeutic-hypothermia-after-cardiac-arrest-and-resuscitation-by-restoring-autophagic-flux-via-the-pi3k-akt-mtor-pathway
#7
JOURNAL ARTICLE
Hui Wang, Wenwen Wang, Zhiwei Xue, Huiping Gong
BACKGROUND: Postresuscitation cardiac dysfunction is a significant contributor to early death following cardiopulmonary resuscitation (CPR). Therapeutic hypothermia (TH) mitigates myocardial dysfunction due to cardiac arrest (CA); however, the underlying mechanism remains unclear. Sirtuin 3 (Sirt3) was found to affect autophagic activity in recent research, motivating us to investigate its role in the cardioprotective effects of TH in the treatment of CA. METHODS: Sprague-Dawley rats were used to establish an in vivo CA/CPR model and treated with a selective Sirt3 inhibitor or vehicle...
March 25, 2024: Shock
https://read.qxmd.com/read/38524686/effect-of-aggressive-warming-versus-routine-thermal-management-on-the-incidence-of-perioperative-hypothermia-in-patients-undergoing-thyroid-surgery-a-prospective-randomized-double-blind-controlled-trial
#8
JOURNAL ARTICLE
Yue Zhang, Yafan Bai, Yi Zhang, Yingjie Du, Min Liu, Jiayu Zhu, Guyan Wang
PURPOSE: Despite the implementation of various insulation measures, the incidence of hypothermia during thyroid surgery remains high. This randomized controlled study aimed to evaluate the effects of aggressive thermal management combined with resistive heating mattresses to prevent perioperative hypothermia in patients undergoing thyroid surgery. PATIENTS AND METHODS: 142 consecutive patients scheduled for elective thyroid surgery were enrolled in the study. They were randomly and equally allocated to the aggressive warming or routine care groups (n = 71)...
2024: Therapeutics and Clinical Risk Management
https://read.qxmd.com/read/38523796/mild-hypothermia-promotes-neuronal-differentiation-of-human-neural-stem-cells-via-rbm3-sox11-signaling-pathway
#9
JOURNAL ARTICLE
Yuxiao Ma, Zhenghui He, Jiangchang Wang, Ping Zheng, Zixuan Ma, Qian Liang, Qiao Zhang, Xiongfei Zhao, Jialin Huang, Weiji Weng, Jiyao Jiang, Junfeng Feng
Both therapeutic hypothermia and neural stem cells (NSCs) transplantation have shown promise in neuroprotection and neural repair after brain injury. However, the effects of therapeutic hypothermia on neuronal differentiation of NSCs are not elucidated. In this study, we aimed to investigate whether mild hypothermia promoted neuronal differentiation in cultured and transplanted human NSCs (hNSCs). A significant increase in neuronal differentiation rate of hNSCs was found when exposed to 35°C, from 33% to 45% in vitro and from 7% to 15% in vivo ...
April 19, 2024: IScience
https://read.qxmd.com/read/38522663/protective-effects-of-different-lyoprotectants-on-survival-of-clinical-bacterial-isolates-in-a-hospital-biobank
#10
JOURNAL ARTICLE
Masoud Alebouyeh, Nasim Almasian Tehrani, Fatemeh Fallah, Leila Azimi, Mehrzad Sadredinamin, Neda Yousefi, Ghazale Ghandchi, Mostafa Haji Molla Hoseini
Nowadays the significant role of biobanks in medical, diagnostic, industrial, and environmental research is well known. Bacterial biobanks could be used as a good resource for designing new treatments, biomedical and industrial researches, and laboratory diagnostics. To have a collection of bacteria from clinical samples and maintain their long-term viability, their preservation needs appropriate protective agents, like cryoprotectants and lyoprotectants. In this study, we collected and characterized Gram-negative and Gram-positive bacteria carrying important antibiotic resistance markers from different clinical samples of hospitalized children...
March 22, 2024: Cryobiology
https://read.qxmd.com/read/38522417/association-between-portal-vein-thrombosis-after-umbilical-vein-catheterization-and-neonatal-asphyxia
#11
JOURNAL ARTICLE
Marina Colella, Anna Zanin, Artemis Toumazi, Aurélie Bourmaud, Priscilla Boizeau, Sophie Guilmin-Crepon, Noémie Leick, Sophea Khat, Marianne Alison, Olivier Baud, Valerie Biran
INTRODUCTION: Neonatal portal vein thrombosis (PVT) is frequently related to umbilical venous catheterization (UVC), but risk factors remain unclear. This study aims to analyze the variables associated to PVT in near- to full-term newborns with UVC, with a focus on newborns exposed to controlled therapeutic hypothermia (CTH) for hypoxic ischemic encephalopathy (HIE). METHODS: This is retrospective cohort study of infants delivered at or after 36 weeks and with a birthweight over 1,500 g...
March 22, 2024: Neonatology
https://read.qxmd.com/read/38520469/perioperative-health-care-professionals-knowledge-of-evidence-based-inadvertent-perioperative-hypothermia-management
#12
JOURNAL ARTICLE
Tugba N Oden, Nihal Celikturk Doruker, Fatma Demir Korkmaz
PURPOSE: To evaluate the perioperative health care professionals' knowledge of evidence-based inadvertent perioperative hypothermia management. DESIGN: A descriptive, cross-sectional study. METHODS: The research sample consisted of 219 perioperative nurses and anesthesia technicians working in the university hospital and participating in perioperative care. Data were collected by the researchers using a questionnaire that included descriptive characteristics of health care professionals and inadvertent perioperative hypothermia management between March and April 2021...
March 21, 2024: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://read.qxmd.com/read/38518773/biofilm-exopolysaccharides-alter-sensory-neuron-mediated-sickness-during-lung-infection
#13
JOURNAL ARTICLE
Elise Granton, Luke Brown, Manon Defaye, Parisa Moazen, Henrik Almblad, Trevor E Randall, Jacquelyn D Rich, Andrew Geppert, Nasser S Abdullah, Mortaza F Hassanabad, Carlos H Hiroki, Raquel Farias, Angela P Nguyen, Courtney Schubert, Yuefei Lou, Graciela Andonegui, Mircea Iftinca, Deepa Raju, Mario A Vargas, P Lynne Howell, Tamás Füzesi, Jaideep Bains, Deborah Kurrasch, Joe Jonathan Harrison, Christophe Altier, Bryan G Yipp
Infections of the lung cause observable sickness thought to be secondary to inflammation. Signs of sickness are crucial to alert others via behavioral-immune responses to limit contact with contagious individuals. Gram-negative bacteria produce exopolysaccharide (EPS) that provides microbial protection; however, the impact of EPS on sickness remains uncertain. Using genome-engineered Pseudomonas aeruginosa (P. aeruginosa) strains, we compared EPS-producers versus non-producers and a virulent Escherichia coli (E...
March 13, 2024: Cell
https://read.qxmd.com/read/38518416/post-exercise-management-of-exertional-hyperthermia-in-dogs-participating-in-dog-sport-canicross-events-in-the-uk
#14
JOURNAL ARTICLE
Anne J Carter, Emily J Hall, Jude Bradbury, Sian Beard, Sophie Gilbert, Dominic Barfield, Dan G O'Neill
Exercise is a common trigger of heat-related illness (HRI) events in dogs, accounting for 74% of canine HRI cases treated under primary veterinary care in the United Kingdom. However, few empirical studies have evaluated the effectiveness of differing cooling methods for dogs with exertional hyperthermia or HRI. This study aimed to prospectively evaluate effects of ambient conditions and post-exercise management practices (cooling methods and vehicular confinement) on the post-exercise temperature change of dogs participating in UK canicross events...
March 11, 2024: Journal of Thermal Biology
https://read.qxmd.com/read/38514793/early-induction-of-cytokine-release-syndrome-by-rapidly-generated-car-t-cells-in-preclinical-models
#15
JOURNAL ARTICLE
Arezoo Jamali, Naphang Ho, Angela Braun, Elham Adabi, Frederic B Thalheimer, Christian J Buchholz
Cytokine release syndrome (CRS) is a significant side-effect of conventional chimeric antigen receptor (CAR) T-cell therapy. To facilitate patient accessibility, short-term (st) CAR T cells, which are administered to patients only 24 h after vector exposure, are in focus of current investigations. Their impact on the incidence and severity of CRS has been poorly explored. Here, we evaluated CD19-specific stCAR T cells in preclinical models. In co-culture with tumor cells and monocytes, stCAR T cells exhibited anti-tumoral activity and potent release of CRS-related cytokines (IL-6, IFN-γ, TNF-α, GM-CSF, IL-2, IL-10)...
March 21, 2024: EMBO Molecular Medicine
https://read.qxmd.com/read/38514524/characterizing-the-impact-of-thermoregulation-in-patients-after-cardiac-arrest-a-retrospective-cohort-study
#16
JOURNAL ARTICLE
Annie Li, Ahmed F Hegazy, Luis E Mendoza Vasquez, Lisa Liu, Alexandra M Durocher, Andrea Vucetic, Arjun Patel, Courtney Fleming, Jason Chui
PURPOSE: Core body temperature has been extensively investigated as a thereuptic target in care after cardiac arrest. Nevertheless, the integrity of thermoregulation in patients after cardiac arrest has not been well studied. We sought to evaluate whether low spontaneous body temperature after cardiac arrest is associated with increased death and a worse neurologic outcome, and whether patients with low spontaneous body temperature exhibit features suggestive of impaired thermoregulation...
March 21, 2024: Canadian Journal of Anaesthesia
https://read.qxmd.com/read/38513998/cryopreserved-leukapheresis-material-can-be-transferred-from-controlled-rate-freezers-to-ultracold-storage-at-warmer-temperatures-without-affecting-downstream-car-t-cell-culture-performance-and-in-vitro-functionality
#17
JOURNAL ARTICLE
Jiaming Wei, Katherine Chaney, Woo Jin Shim, Heyu Chen, Grace Leonard, Sean O'Brien, Ziyan Liu, Jinlin Jiang, Robert Ulrey
Chimeric antigen receptor (CAR) T-cell therapies are increasingly adopted as a commercially available treatment for hematologic and solid tumor cancers. As CAR-T therapies reach more patients globally, the cryopreservation and banking of patients' leukapheresis materials is becoming imperative to accommodate intra/inter-national shipping logistical delays and provide greater manufacturing flexibility. This study aims to determine the optimal temperature range for transferring cryopreserved leukapheresis materials from two distinct types of controlled rate freezing systems, Liquid Nitrogen (LN2)-based and LN2-free Conduction Cooling-based, to the ultracold LN2 storage freezer (≤-135 °C), and its impact on CAR T-cell production and functionality...
March 19, 2024: Cryobiology
https://read.qxmd.com/read/38513997/computer-aided-exploration-of-multiobjective-optimal-temperature-profiles-in-slow-freezing-for-human-induced-pluripotent-stem-cells
#18
JOURNAL ARTICLE
Yusuke Hayashi, Yuki Uno, Masahiro Kino-Oka, Hirokazu Sugiyama
Human induced pluripotent stem (hiPS) cells have demonstrated promising potential in regenerative medical therapeutics. After successful clinical trials, the demand for hiPS cells has steadily increased. Therefore, the optimization of hiPS cell freezing processes for storage and transportation is essential. Here, we presented a computer-aided exploration of multiobjective optimal temperature profiles in slow freezing for hiPS cells. This study was based on a model that calculates cell survival rates after thawing, and the model was extended to evaluate cell potentials until 24 h after seeding...
March 19, 2024: Cryobiology
https://read.qxmd.com/read/38512134/correlation-study-on-the-prognostic-value-of-mir-21-and-s-100b-protein-levels-in-neonatal-hypoxic-ischemic-encephalopathy-undergoing-hypothermia-therapy
#19
JOURNAL ARTICLE
Yan Liu, Nuo-Xuan Liu
OBJECTIVE: To evaluate the variations in serum levels of microRNA-21 (miR-21) and S-100B protein in neonates with hypoxic-ischemic encephalopathy (HIE) after receiving hypothermia therapy and explore the correlation of these biomarkers with the neurodevelopmental prognosis of the infants. METHODS: This retrospective analysis included 90 neonatal HIE patients diagnosed and treated between January 2019 and December 2022. Real-time quantitative PCR and enzyme-linked immunosorbent assay (ELISA) methods were used to measure miR-21 and S-100B protein levels...
March 21, 2024: International Journal of Neuroscience
https://read.qxmd.com/read/38511236/a-quality-improvement-initiative-to-increase-skin-to-skin-care-duration-in-preterm-neonates
#20
JOURNAL ARTICLE
Palanikumar Balasundaram, Melissa Frascone, Samantha Wnukowski, Alana G Murphy, Jillian Connors
BACKGROUND: Skin-to-skin (STS) care effectively improves neonatal outcomes, particularly for preterm neonates. However, utilization of STS remains suboptimal for the most vulnerable preterm neonates in the first 4 weeks of life. This quality improvement (QI) project aimed to increase STS duration for neonates under 35 weeks gestation. METHODS: The QI initiative was conducted in a 35-bed level IV NICU within a teaching hospital in New York City from July 2021 to January 2023...
April 1, 2024: Hospital Pediatrics
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