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https://www.readbyqxmd.com/read/28922588/persistent-negative-symptoms-in-first-episode-psychosis-early-cognitive-and-social-functioning-correlates-and-differences-between-early-and-adult-onset
#1
Olga Puig, Immaculada Baeza, Elena de la Serna, Bibiana Cabrera, Gisela Mezquida, Miquel Bioque, Antonio Lobo, Ana González-Pinto, Mara Parellada, Iluminada Corripio, Eduard Vieta, Julio Bobes, Judith Usall, Fernando Contreras, Manuel J Cuesta, Miquel Bernardo, Josefina Castro-Fornieles, The PEPs Group
OBJECTIVE: To characterize the early cognitive and social functioning characteristics of a sample of first-episode psychosis patients with and without persistent negative symptoms (PNS) and to examine the prevalence and cognitive and functional correlates of PNS in patients with early-onset versus adult-onset first-episode psychosis. METHODS: Participants were 235 patients with first-episode psychosis (51 early-onset, 184 adult-onset) and 240 healthy controls from a multicenter longitudinal study (recruited between 2009 and 2011)...
September 12, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28920570/brain-relevant-antibodies-in-first-episode-psychosis-a-matched-case-control-study
#2
Fiona Gaughran, John Lally, Katherine Beck, Ruaidhri McCormack, Poonam Gardner-Sood, Ester Coutinho, Leslie Jacobson, Bethan Lang, Ricardo Sainz-Fuertes, Evangelos Papanastasiou, Marta Di Forti, Tim Nicholson, Angela Vincent, Robin M Murray
BACKGROUND: There has been much recent excitement about the possibility that some cases of psychosis may be wholly due to brain-reactive antibodies, with antibodies to N-methyl-D-aspartate receptor (NMDAR) and the voltage-gated potassium channel (VGKC)-complex reported in a few patients with first-episode psychosis (FEP). METHODS: Participants were recruited from psychiatric services in South London, UK, from 2009 to 2011 as part of the Genetics and Psychosis study...
September 18, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28919130/the-nuts-and-bolts-of-cognitive-remediation-exploring-how-different-training-components-relate-to-cognitive-and-functional-gains
#3
Matteo Cella, Til Wykes
BACKGROUND: Cognitive Remediation (CR) is an evidence based treatment targeting cognitive and functional difficulties in people with psychosis. Despite the large number of effectiveness studies, only limited evidence exists for the active ingredients of this therapy. This study begins to fill this gap by exploring the relationship between CR ingredients, including alliance with a therapist, and therapy outcomes. METHOD: This is a secondary analysis based on data from a published randomised controlled trial comparing CR+treatment-as-usual (TAU) to TAU alone...
September 14, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28919129/dissecting-the-catatonia-phenotype-in-psychotic-and-mood-disorders-on-the-basis-of-familial-genetic-factors
#4
Victor Peralta, Lourdes Fañanás, Migdyrai Martín-Reyes, Manuel J Cuesta
BACKGROUND: This study examines the familial aggregation (familiality) of different phenotypic definitions of catatonia in a sample of multiplex families with psychotic and mood disorders. METHODS: Participants were probands with a lifetime diagnosis of a DSM-IV functional psychotic disorder, their parents and at least one first-degree relative with a psychotic disorder. The study sample included 441 families comprising 2703 subjects, of whom 1094 were affected and 1609 unaffected...
September 14, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28918863/more-haste-less-speed-a-meta-analysis-of-thinking-latencies-during-planning-in-people-with-psychosis
#5
REVIEW
Andrew J Watson, Eileen M Joyce, Andrew J B Fugard, Verity C Leeson, Thomas R E Barnes, Vyv Huddy
Cognitive impairment is a core feature of psychosis, with slowed processing speed thought to be a prominent impairment in schizophrenia and first-episode psychosis. However, findings from the Stockings of Cambridge (SOC) planning task suggest changes in processing speed associated with the illness may include faster responses in early stages of planning, though findings are inconsistent. This review uses meta-analytic methods to assess thinking times in psychosis across the available literature. Studies were identified by searching PubMed, Web of Science and Google Scholar...
September 5, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28918861/exercise-self-efficacy-correlates-in-people-with-psychosis
#6
Davy Vancampfort, Paul Gorczynski, Marc De Hert, Michel Probst, Annetie Naisiga, David Basangwa, James Mugisha
Despite the recognition of the importance of exercise self-efficacy in exercise adoption and maintenance, previous investigations on exercise self-efficacy in people with psychosis is scarce. The present study aimed to (1) explore if exercise self-efficacy differed between stages of behavior change in Ugandan outpatients with psychosis, and (2) assess sociodemographic, clinical and motivational correlates of exercise self-efficacy. In total, 48 patients (24 women) completed the Exercise Self-Efficacy Scale (ESES), the Patient-centered Assessment and Counseling for Exercise questionnaire, the Brief Symptoms Inventory-18 (BSI-18), and questions pertaining to intrinsic motivation in the Behavioral Regulation in Exercise Questionnaire-2...
September 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28918440/interpersonal-sensitivity-and-persistent-attenuated-psychotic-symptoms-in-adolescence
#7
Alice Masillo, M Brandizzi, L R Valmaggia, R Saba, N Lo Cascio, J F Lindau, L Telesforo, P Venturini, D Montanaro, D Di Pietro, M D'Alema, P Girardi, P Fiori Nastro
Interpersonal sensitivity defines feelings of inner-fragility in the presence of others due to the expectation of criticism or rejection. Interpersonal sensitivity was found to be related to attenuated positive psychotic symptom during the prodromal phase of psychosis. The aims of this study were to examine if high level of interpersonal sensitivity at baseline are associated with the persistence of attenuated positive psychotic symptoms and general psychopathology at 18-month follow-up. A sample of 85 help-seeking individuals (mean age = 16...
September 16, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28917190/posttraumatic-stress-symptoms-and-dissociation-between-childhood-trauma-and-two-different-types-of-psychosis-like-experience
#8
Ji Young Choi
This study examined the roles of posttraumatic stress (PTS) symptoms and dissociation in the relationship between childhood trauma and two different types of psychosis-like experience, including persecutory ideation and aberrant experience, in non-psychotic psychiatric patients. From August 2015 to August 2016, among psychiatric out patients seeking treatment at the Department of Psychiatry at a major teaching medical hospital in Seoul, Korea, 169 patients who had never been diagnosed with a psychotic disorder, including schizophrenia spectrum disorder, bipolar disorder, and/or depressive disorder with psychotic features, completed the Korean Childhood Trauma Questionnaire, the Korean version of the Impact of Event Scale-Revised, the modified Korean version of the Peritraumatic Dissociation Experiences Questionnaire, and the Korean Minnesota Multiphasic Personality Inventory-2 (MMPI-2)...
September 13, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28914403/self-transformation-at-the-boundary-of-religious-conversion-and-psychosis
#9
Szabolcs Kéri
The relationship between religious conversion, as a form of spiritual emergency, and psychosis is one of the fundamental issues at the meeting point of theology and clinical psychology. In the present study, we assessed 53 individuals referred to a psychiatry center with the initial diagnosis of a psychotic episode by focusing on the clinical diagnosis (psychosis vs. spiritual emergency), subjective experiences (basic symptoms), and neuropsychological functions. Twenty-nine individuals meet the diagnosis of schizophrenia-spectrum disorders, but 24 persons experienced only religious and spiritual problems (religious conversion)...
September 15, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28914382/clinical-high-risk-for-psychosis-in-children-and-adolescents-a-systematic-review
#10
REVIEW
Jordina Tor, Montserrat Dolz, Anna Sintes, Daniel Muñoz, Marta Pardo, Elena de la Serna, Olga Puig, Gisela Sugranyes, Inmaculada Baeza
The concept of being at risk for psychosis has been introduced both for adults and children and adolescents, but fewer studies have been conducted in the latter population. The aim of this study is to systematically review the articles associated with clinical description, interventions, outcome and other areas in children and adolescents at risk for psychosis. We searched in MEDLINE/PubMed and PsycINFO databases for articles published up to 30/06/16. Reviewed articles were prospective studies; written in English; original articles with Clinical High Risk (CHR) for psychosis samples; and mean age of samples younger than 18 years...
September 15, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28913001/methamphetamine-use-and-emergency-department-utilization-20-years-later
#11
John R Richards, Sheiva Hamidi, Connor D Grant, Colin G Wang, Nabil Tabish, Samuel D Turnipseed, Robert W Derlet
BACKGROUND: Methamphetamine (MAP) users present to the emergency department (ED) for myriad reasons, including trauma, chest pain, and psychosis. The purpose of this study is to determine how their prevalence, demographics, and resource utilization have changed. METHODS: Retrospective review of MAP patients over 3 months in 2016. Demographics, mode of arrival, presenting complaints, disposition, and concomitant cocaine/ethanol use were compared to a 1996 study at the same ED...
2017: Journal of Addiction
https://www.readbyqxmd.com/read/28911915/risk-factors-of-compliance-with-self-harm-command-hallucinations-in-individuals-with-affective-and-non-affective-psychosis
#12
Jules R Dugré, Jean-Pierre Guay, Alexandre Dumais
Clinicians are often left with the difficult task of assessing and managing the risk of violent behaviors in individuals having command hallucinations, which may result in substantial rates of false positive or false negative. Moreover, findings on the association between command hallucinations and suicidal behaviors are limited. In an attempt to better understand compliance to this hallucinatory phenomenon, our objective was to identify the risk factors of compliance with self-harm command hallucinations. Secondary analyses from the MacArthur Study were performed on 82 participants with psychosis reporting such commands...
September 11, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28911048/what-can-different-motor-circuits-tell-us-about-psychosis-an-rdoc-perspective
#13
Vijay A Mittal, Jessica A Bernard, Georg Northoff
Signs of motor dysfunction are evidenced across a range of psychiatric disorders including schizophrenia. Historically, these features have been neglected but emerging theoretical and methodological advancements have shed new light on the utility of considering movement abnormalities. Indeed, the National Institute of Mental Health Research Domain Criteria initiative has recently met to develop a Motor Systems Domain. This reflects a growing appreciation for the enhanced reliability and validity that can come along with evaluating disturbances relevant to psychiatric illnesses from multiple levels of analysis, and conceptualizing these domains with respect to the complexity of their role in a broader integrated system (ie, weighing contributions and interactions between the cognitive, affective, and motor domains)...
September 1, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28910597/predictors-of-change-in-social-networks-support-and-satisfaction-following-a-first-episode-psychosis-a-cohort-study
#14
Laoise Renwick, Liz Owens, John Lyne, Brian O'Donoghue, Eric Roche, Jonathan Drennan, Ann Sheridan, Mark Pilling, Eadbhard O'Callaghan, Mary Clarke
BACKGROUND: Diminished social networks are common in psychosis but few studies have measured these comprehensively and prospectively to determine how networks and support evolve during the early phase. There is little information regarding perceived support in the early phase of illness. The aim of this study was to describe social support, networks and perceived satisfaction, explore the clinical correlates of these outcomes and examine whether phases of untreated psychosis are linked with social network variables to determine potential opportunities for intervention...
August 30, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28906054/neuropathological-comorbidity-associated-with-argyrophilic-grain-disease
#15
REVIEW
Osamu Yokota, Tomoko Miki, Chikako Ikeda, Shigeto Nagao, Shintaro Takenoshita, Hideki Ishizu, Takashi Haraguchi, Shigetoshi Kuroda, Seishi Terada, Norihito Yamada
Argyrophilic grain disease (AGD) is a common four-repeat tauopathy in elderly people. While dementia is a major clinical picture of AGD, recent studies support the possibility that AGD may be a pathological base in some patients with mild cognitive impairment, late-onset psychosis, bipolar disorder and depression. AGD often coexists with various other degenerative changes. The frequency of AGD in progressive supranuclear palsy (PSP) cases was reported to range from 18.8% to 80%. The frequency of AGD in corticobasal degeneration (CBD) cases tends to be higher than that in PSP cases, ranging from 41...
September 14, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28904730/-tuberculous-meningoencephalitis-revealed-by-psychiatric-disorders-about-a-case
#16
Khalid Mouhadi, Tarik Boulahri, Abdelhadi Rouimi
Tuberculous meningoencephalitis is fairly frequent in endemic countries and it is the most severe form of tuberculosis. Therapeutic failure is common because of diagnostic delay. This delay is primarily due to a wide clinical polymorphism and, in particular, to misleading forms. We here report a rare clinical case of tuberculous meningitis in a patient in prodromal phase of psychosis.
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28904513/autoimmune-thyroiditis-presenting-as-psychosis
#17
Soumitra DAS, Nimisha Doval, Vikas Moun
Hashimoto's thyroiditis is a rare condition associated mainly with neurological symptoms. It contains an abundant amount of auto-antibodies in the blood. Only a few cases of behavioral symptoms without significant neurological disturbances have been recorded in the literature. In this view, our case is unique as it was not associated with overt hypothyroid manifestations.
June 25, 2017: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/28903120/opening-the-black-box-of-cognitive-behavioural-case-management-in-clients-with-ultra-high-risk-for-psychosis
#18
Jessica A Hartmann, Patrick D McGorry, Stefanie J Schmidt, G Paul Amminger, Hok Pan Yuen, Connie Markulev, Gregor E Berger, Eric Y H Chen, Lieuwe de Haan, Ian B Hickie, Suzie Lavoie, Meredith J McHugh, Nilufar Mossaheb, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Rössler, Miriam R Schäfer, Monika Schlögelhofer, Stefan Smesny, Andrew Thompson, Swapna Kamal Verma, Alison R Yung, Barnaby Nelson
BACKGROUND: Cognitive-behavioural therapy (CBT) is the first-choice treatment in clients with ultra-high risk (UHR) for psychosis. However, CBT is an umbrella term for a plethora of different strategies, and little is known about the association between the intensity and content of CBT and the severity of symptomatic outcome. METHODS: A sample of 268 UHR participants received 6 months of CBT with case management (CBCM) in the context of the multi-centre NEURAPRO trial with monthly assessments of attenuated psychotic symptoms (APS)...
September 14, 2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28903079/escalating-patterns-of-emergency-health-care-prior-to-first-admission-with-amphetamine-psychosis-a-window-of-opportunity
#19
Grant Sara, Julia Lappin, Timothy Dobbins, Adrian J Dunlop, Louisa Degenhardt
AIM: To describe health service contact in the two years prior to a first hospital admission with amphetamine-related psychosis, and to identify possible opportunities for early intervention. METHOD: Routine health data collections were used to identify 6130 persons aged 16-65 who had a first hospital admission with amphetamine-related psychosis in New South Wales (NSW), Australia, between 2005 and 2016. Health service contacts in the two years prior to first admission were identified, using public hospital, emergency department and community mental health data...
September 6, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28901686/shifting-the-focus-toward-rare-variants-in-schizophrenia-to-close-the-gap-from-genotype-to-phenotype
#20
REVIEW
M Leonor Bustamante, Luisa Herrera, Pablo A Gaspar, Rodrigo Nieto, Alejandro Maturana, María José Villar, Valeria Salinas, Hernán Silva
Schizophrenia (SZ) is a disorder with a high heritability and a complex architecture. Several dozen genetic variants have been identified as risk factors through genome-wide association studies including large population-based samples. However, the bulk of the risk cannot be accounted for by the genes associated to date. Rare mutations have been historically seen as relevant only for some infrequent, Mendelian forms of psychosis. Recent findings, however, show that the subset of patients that present a mutation with major effect is larger than expected...
October 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
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