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Graves ophthalmopathy

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https://www.readbyqxmd.com/read/27893583/retinal-vessel-oxygen-saturation-and-vessel-diameter-in-inactive-graves-ophthalmopathy
#1
Xiaonan Yang, Danping Huang, Siming Ai, Xuanwei Liang, Jing Zhao, Lei Fang
PURPOSE: To investigate whether inactive thyroid-associated ophthalmopathy (TAO) affects retinal oxygen saturation and/or vessel diameter. METHODS: Via an observational case-control study, retinal circulation was measured in patients with inactive TAO (mild, moderate, and severe) and normal subjects by retinal oximetry. Complete ophthalmologic examination, including noncontact tonometry and Hertel exophthalmometry, was performed; history of smoking and dysthyroid disease were recorded...
November 23, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27872448/cigarette-smoking-number-one-enemy-for-graves-ophthalmopathy
#2
Luigi Bartalena, Eliana Piantanida
No abstract text is available yet for this article.
October 28, 2016: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/27863789/comparative-analysis-of-radioactive-iodine-versus-thyroidectomy-for-definitive-treatment-of-graves-disease
#3
Vincent T Wu, Allison W Lorenzen, Anna C Beck, Vincent J Reid, Sonia L Sugg, James R Howe, Janet H Pollard, Geeta Lal, Ronald J Weigel
BACKGROUND: Management of Graves disease includes antithyroid drugs, (131)I therapy, or thyroidectomy. Our aim was to review our institutional experience with definitive treatments for Graves disease. METHODS: This was a retrospective review of patients undergoing (131)I therapy (n = 295) or thyroidectomy (n = 103) for Graves disease (2003-2015). Demographic, clinical, pathology, and outcome data were collected from institutional databases. RESULTS: (131)I therapy patients were older (39...
November 15, 2016: Surgery
https://www.readbyqxmd.com/read/27855396/imbalance-of-th17-treg-in-different-subtypes-of-autoimmune-thyroid-diseases
#4
Cui Li, Jianghong Yuan, Yuan-Feng Zhu, Xiang-Ju Yang, Qiong Wang, Jian Xu, Shuang-Tao He, Jin-An Zhang
AIMS: To clarify the imbalance of Th17/Treg in different subtypes of autoimmune thyroid diseases (AITDs) including Graves' disease(GD), Hashimoto's thyroiditis(HT) and Graves' ophthalmopathy (GO). METHODS: 47 patients with AITD (including 16 GD, 15 HT, and 16 GO) and 12 healthy controls were enrolled in this study. The percentages of Th17 and Treg cells, the ratio of Th17/Treg, as well as their related transcription factors RORγt and Foxp3 mRNA in peripheral blood mononuclear cells (PBMCs) were measured by flow cytometry and real-time quantitative PCR Results: Compared with those in control group, the percentage of CD4+IL-17+T cell(Th17) and the mRNA expression of its transcription factor RORγt were higher in PBMCs of AITDs (P<0...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27853049/comparison-of-two-different-regimens-of-intravenous-methylprednisolone-for-patients-with-moderate-to-severe-and-active-graves-ophthalmopathy-a-prospective-randomized-controlled-trial
#5
Yebing He, Ketao Mu, Rong Liu, Jing Zhang, Nan Xiang
The intravenous methylprednisolone (iv MP) strategy for Graves' ophthalmopathy (GO) and evaluation of its activity against the disease warrants further exploration. A prospective randomized controlled trial for 3 months was performed in a tertiary referral teaching hospital to compare the efficacy and safety of two different regimens of iv MP, and determine the value of clinical activity score (CAS) and T2 relaxation time (T2RTs) and areas of extraocular muscles (EOMs) by magnetic resonance imaging for diagnosis of active GO...
November 16, 2016: Endocrine Journal
https://www.readbyqxmd.com/read/27829681/gender-dependent-and-age-of-onset-specific-association-of-the-rs11675434-single-nucleotide-polymorphism-near-tpo-with-susceptibility-to-graves-ophthalmopathy
#6
Aleksander Kuś, Konrad Szymański, Beata Jurecka-Lubieniecka, Edyta Pawlak-Adamska, Dorota Kula, Piotr Miśkiewicz, Marek Bolanowski, Rafał Płoski, Artur Bossowski, Jacek Daroszewski, Barbara Jarząb, Tomasz Bednarczuk
The role of TPO gene polymorphism in the susceptibility to Graves' disease (GD) remains unclear. However, single-nucleotide polymorphisms (SNPs) near TPO have been recently associated with serum levels of thyroid peroxidase (TPO) antibody in two independent genome-wide association studies. Moreover, we have observed a strong association between the rs11675434 SNP located near TPO and the presence of clinically evident Graves' ophthalmopathy (GO). The aim of the current study was to reevaluate and dissect this association in an extended group of 1231 well-characterized patients with GD (1043 adults and 188 children) and 1130 healthy controls from the Polish Caucasian population, considering possible gender-dependent and age-of-onset-specific effects of the studied SNP...
November 10, 2016: Journal of Human Genetics
https://www.readbyqxmd.com/read/27819113/serum-immunoglobulin-g4-levels-and-graves-disease-phenotype
#7
Carmen Sorina Martin, Anca Elena Sirbu, Minodora Andreea Betivoiu, Suzana Florea, Carmen Gabriela Barbu, Simona Vasilica Fica
PURPOSE: We investigated, at diagnosis, the relationship between serum immunoglobulin G4 levels and the main characteristics of Graves' disease: hyperthyroidism severity, goiter size, presence of active Graves' ophthalmopathy, antithyroid antibodies status, and titer. METHODS: This prospective study included 80 newly diagnosed Graves' disease patients. The main parameters measured at diagnosis: thyroid-stimulating hormone, free thyroxine, free triiodothyronine, total triiodothyronine, thyroglobulin, antithyroid peroxidase antibodies, anti-thyroglobulin antibodies, thyroid-stimulating hormone receptor antibodies, immunoglobulin G4...
November 7, 2016: Endocrine
https://www.readbyqxmd.com/read/27771241/botulinum-toxin-for-treatment-of-restrictive-strabismus
#8
Pilar S Merino, Rebeca E Vera, Laura G Mariñas, Pilar S Gómez de Liaño, Jose V Escribano
PURPOSE: To study the types of acquired restrictive strabismus treated in a tertiary hospital and the outcome of treatment with botulinum toxin. METHODS: We performed a 10-year retrospective study of patients with restrictive strabismus aged ≥18 years who were treated with botulinum toxin. Treatment was considered successful if the final vertical deviation was ≤5 PD, horizontal deviation ≤10 PD, with no head turn or diplopia. RESULTS: We included 27 cases (mean age, 61...
October 19, 2016: Journal of Optometry
https://www.readbyqxmd.com/read/27768856/elevated-serum-tetrac-in-graves-disease-potential-pathogenic-role-in-thyroid-associated-ophthalmopathy
#9
Roshini Fernando, Ekaterina Placzek, Edmund A Reese, Andrew T Placzek, Samantha Schwartz, Aaron Trierweiler, Leslie M Niziol, Stephen Atkins, Thomas S Scanlan, Terry J Smith
CONTEXT: The sources and biological impact of 3,3',5,5' tetraiodothyroacetic acid (TA4) are uncertain. CD34(+) fibrocytes express several proteins involved in the production of thyroid hormones. They infiltrate the orbit in Graves' disease (GD), an autoimmune process known as thyroid-associated ophthalmopathy. It appears that the thyrotropin receptor (TSHR) plays an important role in the pathogenesis of TAO. OBJECTIVE: To quantify levels of TA4 in healthy subjects and those with Graves' disease...
October 21, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27730666/pre-tibial-mixedema-a-case-report-with-scanning-electron-microscopy
#10
R R da Cunha Filho, H L de Almeida, J D Basei, R H Camina, L A S de Castro
Pretibial myxedema (PTM) results from the accumulation of hyaluronic acid in the dermis and subcutis and is commonly associated with Graves' disease (GD). It occurs in up to 5% of patients with GD and in 13% of patients with GD and ophthalmopathy. PTM occasionally occurs in thyrotoxicosis but is much less frequently in patients with Hashimoto thyroiditis, primary hypothyroidism and euthyroidism. This article is protected by copyright. All rights reserved.
October 12, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27682712/an-update-on-thyroid-associated-ophthalmopathy-in-children-and-adolescents
#11
Justyna Szczapa-Jagustyn, Anna Gotz-Więckowska, Jarosław Kocięcki
BACKGROUND: Risk of developing thyroid-associated ophthalmopathy (TAO) in children and adolescents is similar or may be even slightly higher than in adults. The aim of this article is to review and summarize current knowledge regarding diagnostic and therapeutic measures in pediatric TAO. CONTENT: MEDLINE and EMBASE papers were searched using the terms 'pediatric Graves' ophthalmopathy' 'pediatric Graves' orbitopathy', 'thyroid-associated ophthalmopathy in childhood and adolescence' from the year 1970 to December 2015...
October 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27674870/the-role-of-external-radiation-therapy-in-patients-with-steroid-refractory-intolerant-symptomatic-graves-ophthalmopathy
#12
A Haydaroglu, B Akbelen, S Alanyali, T Kabalak, E D Biler, O Uretmen, S Kamer
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27664101/natural-course-of-mild-graves-orbitopathy-is-it-a-chronic-remitting-or-a-transient-disease
#13
P Anagnostis, K Boboridis, F Adamidou, M Kita
BACKGROUND/AIMS: The natural course of Graves' orbitopathy (GO) has been poorly documented. The aim of this review is to provide current knowledge regarding the natural course of mild GO, trying to address the issue of whether and to what extent it constitutes a chronic remitting or transient disease. METHODS: We systematically searched PubMed for English language publications until August 2016 under the following terms: "Graves' orbitopathy" OR "Graves' ophthalmopathy" OR "thyroid eye disease" AND "natural course" OR "natural history"...
September 23, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27612658/thyrotropin-and-cd40l-stimulate-interleukin-12-expression-in-fibrocytes-implications-for-pathogenesis-of-thyroid-associated-ophthalmopathy
#14
Tong Wu, Tünde Mester, Shivani Gupta, Fengyuan Sun, Terry J Smith, Raymond S Douglas
BACKGROUND: Increased numbers of bone marrow-derived progenitor cells, known as fibrocytes, populate the peripheral circulation, orbit, and thyroid of patients with Graves' disease (GD). These cells have been implicated in the development of thyroid-associated ophthalmopathy. They can differentiate into myofibroblasts or adipocytes, produce inflammatory cytokines, and remodel tissue. This study sought to determine whether thyrotropin (TSH) and CD40 ligand (CD40L), implicated in the pathogenesis of GD, induce interleukin-12 (IL-12) in human fibrocytes...
October 18, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27610652/hypoxia-dependent-hif-1-activation-impacts-on-tissue-remodeling-in-graves-ophthalmopathy-implications-for-smoking
#15
Gina-Eva Görtz, Mareike Horstmann, Barbara Aniol, Buena Delos Reyes, Joachim Fandrey, Anja Eckstein, Utta Berchner-Pfannschmidt
CONTEXT: In Graves' ophthalmopathy (GO) inflammation with tissue expansion in a closed compartment like the bony orbit and smoking may cause tissue hypoxia. OBJECTIVES: In this study we investigated whether Hypoxia-inducible factor-1 (HIF-1) action impacts on tissue remodeling in GO with the aim to identify possible new therapeutic targets. DESIGN/SETTING/PARTICIPANTS: Orbital fibroblast (OF) were derived from GO patients and control persons (Ctrl)...
September 9, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27568184/ophthalmic-clues-to-the-endocrine-disorders
#16
Z Liu, Y Chen, Z Lin, X Shi
PURPOSE: Eye is a vital sense organ and reflects the physical and mental wellbeing of a person. Detailed examination of the eye is an essential part in the clinical evaluation of patients with any systemic disorder. The interaction between ophthalmologists and endocrinologists is often limited to Graves' ophthalmopathy and diabetic retinopathy. However, there are many ophthalmic manifestations, which are characteristically seen in endocrine disorders. In this review, we shall discuss the ocular manifestations of the endocrine syndromes excluding the Graves' ophthalmopathy and diabetic retinopathy...
August 27, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27566533/steroid-induced-thyrotoxic-periodic-paralysis-during-graves-ophthalmopathy-treatment
#17
Z A Sayiner, A Eraydın, E Akarsu
No abstract text is available yet for this article.
August 26, 2016: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/27543288/expression-and-clinical-significance-of-connective-tissue-growth-factor-ctgf-in-graves-ophthalmopathy
#18
Yi-Ming Huang, Pei-Chen Chang, Shi-Bei Wu, Hui-Chuan Kau, Chieh-Chih Tsai, Catherine Jui-Ling Liu, Yau-Huei Wei
AIMS: To examine the expression of connective tissue growth factor (CTGF) in human cultured orbital fibroblasts from patients with Graves' ophthalmopathy (GO) and investigate whether a correlation exists between the presence of CTGF protein and clinical parameters of the disease. METHODS: The protein expression levels of CTGF were analysed by western blots in cultured orbital fibroblasts from 10 patients with GO and 7 age-matched normal controls. Associations between the protein expression of CTGF and the clinical factors of GO, including clinical demographics, thyroid function, clinical activity score (CAS) and ophthalmopathy index (OI), was evaluated...
August 19, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27534827/efficacy-and-safety-of-radioiodine-therapy-for-mild-graves-ophthalmopathy-in-dependence-on-cigarette-consumption-a-half-year-of-follow-up
#19
Agata Czarnywojtek, Krzesisława Komar-Rychlicka, Małgorzata Zgorzalewicz-Stachowiak, Nadia Sawicka-Gutaj, Kosma Woliński, Paweł Gut, Maria Płazinska, Barbara Torlińska, Ewa Florek, Joanna Waligórska-Stachura, Marek Ruchała
INTRODUCTION    Graves' Orbitopathy (GO) is an autoimmune disease associated with Graves' disease. Therapy is largely dependent on the severity and activity of ocular changes. Particular attention should be given to radioiodine therapy (RIT). Although its application is a valuable method of the treatment of hyperthyroidism, it may be followed by worsening of GO. OBJECTIVES    The aim of the present article is to indicate how the severity of nicotine addiction influences the response for RAI treatment in GO patients...
August 18, 2016: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/27489513/volumetric-modulated-arc-therapy-vmat-make-a-difference-in-retro-orbital-irradiation-treatment-of-patients-with-bilateral-graves-ophthalmopathy-comparative-analysis-of-dosimetric-parameters-from-different-radiation-techniques
#20
Iñigo San-Miguel, Ruth Carmona, Luis Luque, Raquel Cabrera, Marta Lloret, Francisco Rutllan, Pedro Carlos Lara
BACKGROUND: Graves' ophthalmopathy is the commonest extrathyroidal manifestation of Graves' disease. Treatment options include steroid therapy, corrective/decompressive surgery, radiation therapy or combination of these approaches. AIM: Our purpose was to investigate if retro-orbital irradiation with Volumetric Modulated Arc Therapy (VMAT) yielded better target coverage and dose sparing to adjacent normal structures compared to 3-Dimensional Conformal Radiotherapy (3DCRT) and Lateral Opposing Conformed Fields (LOCF)...
September 2016: Reports of Practical Oncology and Radiotherapy
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