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Thyroid eye disease

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https://www.readbyqxmd.com/read/28328557/lateral-rectus-muscle-expands-more-than-medial-rectus-following-maximal-deep-balanced-orbital-decompression
#1
Adit Gupta, Alex Nobori, Yi Wang, Daniel Rootman, Robert Goldberg
PURPOSE: It has been reported that extraocular muscles can enlarge following orbital decompression in thyroid eye disease. In this article, the authors studied the changes in extraocular muscles size following maximal deep lateral and medial balanced decompression in a large sample of thyroid eye disease patients. METHODS: Imaging data were reviewed preoperatively and postoperatively. Radiologic proptosis was assessed. Maximal axial muscle width of the medial and lateral recti was measured...
March 21, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28319174/simultaneous-induction-of-graves-hyperthyroidism-and-graves-ophthalmopathy-by-tshr-genetic-immunization-in-balb-c-mice
#2
Nan Xia, Xiaozhen Ye, Xiaohao Hu, Shiyu Song, Hui Xu, Mengyuan Niu, Hongwei Wang, Jian Wang
BACKGROUND: Graves' disease is the most common form of autoimmune thyroid disorder, characterized by hyperthyroidism due to circulating autoantibodies. To address the pathological features and establish a therapeutic approach of this disease, an animal model carrying the phenotype of Graves' disease (GD) in concert with Graves' Ophthalmopathy (GO) will be very important. However, there are no ideal animal models that are currently available. The aim of the present study is to establish an animal model of GD and GO disease, and its pathological features were further characterized...
2017: PloS One
https://www.readbyqxmd.com/read/28303065/bilateral-lacrimal-caruncle-lesions
#3
Yuta Okumura, Yoshiko Takai, Shunsuke Yasuda, Hiroko Terasaki
A 65-year-old man was referred to our hospital for the treatment of a lesion on the medial lacrimal canthus of both eyes. He had a history of perinuclear anti-neutrophil cytoplasmic antibodies, i.e., pANCA-positive interstitial pneumonia. Orbital magnetic resonance imaging excluded space occupying lesions, and laboratory testing excluded thyroid-related diseases. The masses were excised, and histopathological examinations showed sebaceous gland hyperplasia and inflammatory changes around the gland. In addition, the specimen from the left eye showed a retention cyst possibly caused by an infection...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28296512/management-of-thyroid-eye-disease-in-the-united-kingdom-a-multi-centre-thyroid-eye-disease-audit
#4
F E Mellington, C M Dayan, A J Dickinson, J L Hickey, C J MacEwen, J McLaren, P Perros, G E Rose, J Uddin, B Vaidya, P Foley, J H Lazarus, A Mitchell, D G Ezra
This article aims to provide baseline data and highlight any major deficiencies in the current level of care provided for adult patients with thyroid eye disease (TED). We undertook a prospective, nonrandomized cross-sectional multicenter observational study. During a 3-month period June-August 2014, consecutive adult patients with TED who presented to nominated specialist eye clinics in the United Kingdom, completed a standardized questionnaire. Main outcome measures were: demographics, time from diagnosis to referral to tertiary centre, time from referral to review in specialist eye clinic, management of thyroid dysfunction, radioiodine and provision of steroid prophylaxis, smoking, and TED classification...
March 15, 2017: Orbit
https://www.readbyqxmd.com/read/28291193/-surgical-rehabilitation-of-patients-with-thyroid-eye-disease-systematic-approach
#5
S E Avetisov, Ya O Grusha, D S Ismailova, P A Kochetkov, S S Danilov, N Yu Sviridenko
AIM: to analyze the results of surgical treatment of patients with thyroid eye disease (TED), including the type of surgery, indications, and outcomes. MATERIAL AND METHODS: Hundred thirty-nine patients with TED (112 females, 27 males) aged 45.8±13.6 years. RESULTS: Bony orbital decompression was performed in 91 patients (128 orbits). After the surgery, visual acuity increased from 0.84±0.47 up to 0.94±0.32 (р<0.05), exophthalmos got reduced by the average of 3...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28288723/clinical-features-and-management-of-non-gastrointestinal-non-ocular-extranodal-mucosa-associated-lymphoid-tissue-enmalt-marginal-zone-lymphomas
#6
REVIEW
Estella Matutes, Carlos Montalban
Extranodal mucosa associated lymphoid tissue (ENMALT) marginal zone lymphomas may arise at any site of the body. The most frequent localizations other than gastrointestinal and eye are salivary gland, skin, lung and thyroid. These lymphomas usually arise in a setting of inflammation due to a persistent infection or autoimmune diseases such as Sjogren syndrome in salivary MALT lymphomas and Hashimoto's thryroiditis in thyroid lymphomas. They affect middle-aged patients with a female predominance when lymphoma arises in certain locations...
March 2017: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/28260364/-multi-wall-orbital-decompression-for-disfiguring-proptosis-in-patients-with-mild-or-moderate-thyroid-eye-disease
#7
Y Wang, N Yang, Y Y Li, L H Xiao
Objective: To evaluate the efficacy of orbital decompression by transconjunctival medial and inferior wall combined transpalpebral lateral wall for disfiguring proptosis with mild or moderate thyroid eye disease (TED). Methods: It is a retrospective case series study. The clinical data of 18 TED cases (28 orbits) between Dec 2013 and Dec 2015 at the Institute of Orbital Diseases of the General Hospital of the Armed Police were reviewed. All the patients underwent mulit-wall orbital decompression to relieve remarkable proptosis, widen eyelid fissure, and swollen eyelid...
February 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28255299/selenium-and-thyroid-disease-from-pathophysiology-to-treatment
#8
REVIEW
Mara Ventura, Miguel Melo, Francisco Carrilho
Introduction. Selenium is a micronutrient embedded in several proteins. In adults, the thyroid is the organ with the highest amount of selenium per gram of tissue. Selenium levels in the body depend on the characteristics of the population and its diet, geographic area, and soil composition. In the thyroid, selenium is required for the antioxidant function and for the metabolism of thyroid hormones. Methods. We performed a review of the literature on selenium's role in thyroid function using PubMed/MEDLINE...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28255288/orbital-decompression-for-thyroid-eye-disease
#9
REVIEW
Tara L Braun, Mohin A Bhadkamkar, Kevin T Jubbal, Adam C Weber, Douglas P Marx
Although most cases of thyroid eye disease (TED) can be managed medically, some refractory or severe cases are treated surgically with orbital decompression. Due to a lack of randomized controlled trials comparing surgical techniques for orbital decompression, none have been deemed superior. Thus, each case of TED is managed based on patient characteristics and surgeon experience. Surgical considerations include the extent of bony wall removal, the surgical approach, the choice of incision, and the use of fat decompression...
February 2017: Seminars in Plastic Surgery
https://www.readbyqxmd.com/read/28181061/changing-trend-in-referral-to-secondary-care-specialist-thyroid-eye-disease-clinic-following-the-amsterdam-declaration
#10
Annika S Quinn, Leticia R Dujardin, Bridget Knight, James Benzimra, Anthony G Quinn, Bijay Vaidya
INTRODUCTION: Early diagnosis and treatment of thyroid eye disease (TED) improves outcomes. Previous studies have highlighted delays in diagnosis and referral to specialist centres. The Amsterdam declaration (2009) aimed to halve the time from presentation to diagnosis and from diagnosis to referral to a specialist centre in five years. A recent study from the European group on Graves' orbitopathy tertiary centres showed a trend for earlier referral of patients to the centres. It is unknown whether similar improvements are occurring in secondary care hospitals in the UK...
February 8, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28168320/intraoperative-identification-of-the-parathyroid-gland-with-a-fluorescence-detection-system
#11
Yoshiaki Shinden, Akihiro Nakajo, Hideo Arima, Kiyonori Tanoue, Munetsugu Hirata, Yuko Kijima, Kosei Maemura, Shoji Natsugoe
BACKGROUND: Intraoperative identification of the difficult-to-spot parathyroid gland is critical during surgery for thyroid and parathyroid disease. Recently, intrinsic fluorescence of the parathyroid gland was identified, and a new method was developed for intraoperative detection of the parathyroid with an original fluorescent detection apparatus. Here, we describe a method for intraoperative detection of the parathyroid using a ready-made photodynamic eye (PDE) system without any fluorescent dye or contrast agents...
February 6, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28149156/patient-radiation-biological-risk-in-computed-tomography-angiography-procedure
#12
M Alkhorayef, E Babikir, A Alrushoud, H Al-Mohammed, A Sulieman
Computed tomography angiography (CTA) has become the most valuable imaging modality for the diagnosis of blood vessel diseases; however, patients are exposed to high radiation doses and the probability of cancer and other biological effects is increased. The objectives of this study were to measure the patient radiation dose during a CTA procedure and to estimate the radiation dose and biological effects. The study was conducted in two radiology departments equipped with 64-slice CT machines (Aquilion) calibrated according to international protocols...
February 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28139160/the-relation-between-sleep-disruption-and-cataract-in-a-large-population-based-study
#13
Yanjun Chen, David M Nondahl, Carla R Schubert, Barbara E K Klein, Ronald Klein, Karen J Cruickshanks
PURPOSE: To investigate the relation between sleep disruption and nuclear cataract, as well as the impact of cataract removal on sleep, in two discrete population-based cohorts. METHODS: This is a cross-sectional study of 5070 participants from three large longitudinal epidemiologic studies of age-related eye disease, hearing, olfaction, and cognition. Slit-lamp photos of the lens were obtained to grade nuclear cataract using a standardized protocol. The quality of sleep was assessed using a modified Wisconsin Sleep Cohort Study questionnaire...
April 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28135877/disparities-in-health-supervision-for-children-with-down-syndrome
#14
Katie Williams, David Wargowski, Jens Eickhoff, Ellen Wald
Increasing evidence suggests children with Down syndrome do not receive recommended health care services. We retrospectively assessed adherence to the 2001 American Academy of Pediatrics health supervision guidelines for 124 children with Down syndrome. Cervical spine radiographs were completed for 94% of children, often preoperatively. Adherence to complete blood count recommendations was 55% (95% CI 44% to 66%); lower for males ( P = .01) and children with private medical insurance ( P = .04). Adherence to thyroid function recommendations was 61% (95% CI 54% to 67%); higher for children seen by a pediatrician ( P = ...
January 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28133945/objective-and-subjective-outcomes-of-strabismus-surgery-in-graves-orbitopathy-a-prospective-multicentre-study
#15
Hinke Marijke Jellema, Peerooz Saeed, Ilse Mombaerts, Peter J Dolman, Jim Garrity, Mike Kazim, Elona Dhrami-Gavazi, Christopher Lyons, Pythia Nieuwkerk, Maarten P Mourits
PURPOSE: To assess the change and interrelationship of the field of binocular single vision (BSV) and the quality of life (QoL), tested with two different tools, after one or two strabismus surgeries in patients with Graves' orbitopathy (GO). METHODS: Prospectively, consecutive patients with GO who were scheduled for their first strabismus surgery were recruited from five centres specialized in the treatment of GO. One week preoperatively and 3 months after the last operation, a full ophthalmic and orthoptic examination was performed...
January 30, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28130690/the-role-of-patient-s-systemic-characteristics-and-plateletcrit-in-developing-toxic-anterior-segment-syndrome-after-uneventful-phaco-surgery-a-case-control-study
#16
Serpil Yazgan, Ugur Celik, Orhan Ayar, Suat Hayri Ugurbas, Burcu Celik, Mehmet Orçun Akdemir, Silay Canturk Ugurbas, Atilla Alpay
PURPOSE: To compare the systemic and ocular characteristics and laboratory findings of patients developing toxic anterior segment syndrome (TASS) after uneventful phaco surgery with unaffected subjects undergoing the same surgery in the same session. DESIGN: A retrospective case-control study. METHODS: The study group consisted of 26 eyes of 26 patients who underwent uneventful phaco surgery and who went on to develop TASS, while the control group included 39 subjects who had routine phaco surgery in the same session by the same surgeon...
January 27, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28092393/surgical-treatment-of-adult-onset-esotropia-characteristics-and-outcomes
#17
Sara F Grace, Kara M Cavuoto, Wei Shi, Hilda Capo
PURPOSE: To describe the characteristics of the strabismus, surgical management, and outcomes of patients who underwent surgery for adult-onset esotropia. METHODS: This was a retrospective case study of patients at an academic tertiary referral center who underwent surgical treatment of esotropia acquired at or after age 18 years. Primary outcome measures were resolution of diplopia in primary position and a deviation of 10 prism diopters or less in primary gaze...
January 13, 2017: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28089937/surgical-outcomes-of-unilateral-recession-resection-for-vertical-strabismus-in-patients-with-thyroid-eye-disease
#18
Ju-Yeun Lee, Kyung-Ah Park, Kyung In Woo, Yoon-Duck Kim, Sei Yeul Oh
PURPOSE: To present the surgical outcomes of vertical muscle resection in patients with thyroid eye disease (TED). METHODS: The medical records of 6 patients who underwent unilateral vertical muscle recession-resection to correct vertical strabismus in TED were reviewed retrospectively for postoperative angle of vertical deviation on days 1 and 7 and at months 1, 3, 6, and 12. Surgery was considered successful if the vertical deviation was ≤4(Δ). Reoperation rates and complications were also noted...
February 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28078992/smoking-and-eye-pathologies-a-systemic-review-part-ii-retina-diseases-uveitis-optic-neuropathies-thyroid-associated-orbitopathy
#19
Małgorzata Nita, Andrzej Grzybowski
BACKGROUND: Tobacco smoking has detrimental influence on human health. AIM: The analysis of influence of tobacco smoking on retina diseases, uveitis, optic neuropathies, and thyroidassociated orbitopathy in adults and children. METHODS: A comprehensive review of the literature performed through MEDLINE and PubMed searches, covering the years 2000-2016. RESULTS: In adults, tobacco smoking is a strong risk factor for age-related macular degeneration, polypoidal choroidal vasculopathy, uveitis and inflamed cystoid macular edema as well as Grave`s ophthalmopathy...
2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28077500/distinct-inflammatory-gene-expression-in-extraocular-muscle-and-fat-from-patients-with-graves-orbitopathy
#20
Ivana Lopes Romero-Kusabara, José Vital Filho, Nilza Maria Scalissi, Keli Cardoso Melo, Giovanni Demartino, Carlos Alberto Longui, Murilo Rezende Melo, Adriano Namo Cury
OBJECTIVE: This study sought to compare patients with thyroid eye disease (TED) and normal controls with respect to the expression of the NR3C1, CHUK, IKBKB, FOS, NFKB and HSD11B1 genes in orbital fat (OF) and extraocular muscle (EOM). DESIGN AND METHODS: A prospective study design was used to evaluate 34 TED patients and 38 healthy controls. OF was harvested from 33 TED patients and 27 controls. EOM biopsies were obtained from 32 TED patients and 18 controls. Samples were examined by real-time PCR and evaluated using appropriate statistical analyses with a significance cut-off of P < 0...
April 2017: European Journal of Endocrinology
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