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Thyroid eye disease

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https://www.readbyqxmd.com/read/29649988/the-function-and-morphology-of-meibomian-glands-in-patients-with-thyroid-eye-disease-a-preliminary-study
#1
Chia-Yu Wang, Ren-Wen Ho, Po-Chiung Fang, Hun-Ju Yu, Chun-Chih Chien, Chang-Chun Hsiao, Ming-Tse Kuo
BACKGROUND: To investigate function and morphology of the meibomian gland (MG) in patients with thyroid eye disease (TED). METHODS: In this prospective case series study, patients with unilateral or bilateral TED were consecutively enrolled. The diagnosis of TED was based on the typical orbital findings and/or radiographic evidence. The disease activity of TED was classified according to the clinical activity score (CAS). Degrees of lagophthalmos and exophthalmos, blinking rates, and results of the Schirmer test 1 were also recorded...
April 12, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29594055/occurrence-of-graves-orbitopathy-and-graves-hyperthyroidism-after-a-trauma-to-the-eye
#2
Elena Sabini, Ilaria Ionni, Roberto Rocchi, Paolo Vitti, Claudio Marcocci, Michele Marinò
Background: Graves' orbitopathy (GO) is believed to be the consequence of autoimmunity against antigens that are present both in the thyroid and orbital tissues. Massive release of thyroid antigens causes the appearance or deterioration of GO in patients with Graves' hyperthyroidism (GH), as it occurs following radioiodine treatment. In theory, a similar release of autoantigens may occur at the eye level, for example due to an orbital trauma or surgical manipulation. To our knowledge, this is the first report of a case of de novo appearance of GO and then GH after an eye trauma, possibly reflecting spreading of autoantigens and activation of the immune system against shared orbital and thyroid antigens...
January 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29574428/thyrotoxic-crisis-as-an-acute-clinical-presentation-in-a-child
#3
Adam Bonfield, Savitha Shenoy
A previously well, 4-year-old girl presented with a 4-6 weeks' history of increased appetite, weight loss, tiredness, sleep difficulty, excessive sweating, swelling in the neck and new-onset 'prominent, protruding eyes.' Family history revealed paternal grandmother receiving treatment for hyperthyroidism. Clinical assessment demonstrated features of thyrotoxicosis (tachycardia, warm peripheries, small smooth goitre with no nodules, exophthalmos). TFT (Free T4=101 pmol/L, thyroid-stimulating hormone <0...
March 23, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29546048/changes-of-nicotinamide-phosphoribosyltransferase-expressions-in-thyroid-glands-of-patients-with-different-thyroid-pathologies
#4
Nadia Sawicka-Gutaj, Mirosław Andrusiewicz, Agata Czarnywojtek, Joanna Waligórska-Stachura, Maciej Biczysko, Jerzy Skrobisz, Jerzy Sowiński, Marek Ruchała
Purpose: Our aim was to analyze NAMPT expression in thyroid tissue derived from patients with Graves' disease with (GD) and without (GO) orbitopathy, patients with toxic nodular goiters (TNG) and thyroid cancers (TC), and healthy controls. Methods: 153 thyroid tissue samples of consecutive patients who underwent thyroidectomy were collected. Previous therapy with steroids was an exclusion criterion. We collected clinicopathological data of all subjects and we assessed NAMPT expression using qPCR...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29517594/orbital-radiotherapy-combined-with-corticosteroid-treatment-for-thyroid-eye-disease-compressive-optic-neuropathy
#5
Katherine G Gold, Stacy Scofield, Steven R Isaacson, Michael W Stewart, Michael Kazim
PURPOSE: To evaluate the effectiveness of orbital radiotherapy (ORT) in the treatment of thyroid eye disease (TED)-compressive optic neuropathy. METHODS: A retrospective review of patients with corticosteroid-responsive compressive optic neuropathy due to TED treated with ORT. Study was conducted in compliance with Health Insurance Portability and Accountability Act. One hundred four patients (163 orbits) with a mean age of 61.7 years met inclusion criteria. Seventy-four percent (77/104) were female, and 32...
March 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29505466/measurement-of-medial-wall-bowing-and-clinical-associations-in-thyroid-eye-disease
#6
Christine L Bokman, Shoaib Ugradar, Daniel B Rootman
PURPOSE: To propose and validate a measure of medial wall bowing in thyroid eye disease (TED) and to assess the clinical correlates of bowing in TED. METHODS: In this cross-sectional cohort study, all patients affected with TED seen by a single specialist over a 2-year period were screened for study entry. Eligible participants were adults with clinical evidence of TED and either CT or MRI of the orbits. Exclusion criteria included prior history of decompression surgery and/or medical or other ophthalmic conditions that could alter the orbital anatomy...
March 2, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29489658/positron-emission-tomography-computed-tomography-scan-of-vogt-koyanagi-harada-syndrome-with-associated-autoimmune-thyroid-disease-a-case-report-and-literature-review
#7
Ke-Hao Huang, Ming-Cheng Tai, Lung-Chi Lee, Tzu-Heng Weng, Yi-Hao Chen, Li-Fan Lin, Jiann-Torng Chen, Da-Wen Lu, Ching-Long Chen
RATIONALE: Vogt-Koyanagi-Harada (VKH) syndrome is a rare disease and could be associated with autoimmune thyroid disease (AITD). This report was aimed to investigate the utility of F-fludeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) for the diagnosis of VKH syndrome with AITD and to perform a literature review on the association between the 2 diseases. PATIENT CONCERNS: A 55-year-old woman without the history of ocular trauma suffered from chronic headache...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29485308/rectus-muscle-resection-for-vertical-strabismus-in-thyroid-eye-disease
#8
Filofteia Tacea, Edward Loane, Andre Grixti, Ian B Marsh, Kimia Ziahosseini
PURPOSE: Rectus muscle resection in thyroid eye disease (TED) is generally avoided due to the risk of worsening restriction or reactivating inflammation. However, for some patients with large-angle strabismus or diplopia in primary gaze despite maximum recession surgery, rectus muscle resection may be beneficial. We report our surgical experience with rectus muscle resection in the management of vertical strabismus associated with TED. METHODS: Retrospective review of eight patients with TED and vertical diplopia who underwent vertical rectus muscle resection by a single surgeon (IBM) at a tertiary referral centre in Liverpool, UK, from 2001 to 2013...
February 27, 2018: Strabismus
https://www.readbyqxmd.com/read/29482520/extraocular-muscle-repositioning-as-the-last-therapeutic-option-for-a-patient-with-a-severe-course-of-graves-ophthalmopathy-a-case-report
#9
Andrea Rau, Matthias Klopfer, Niklas Rommel, Mechthild Rau-Fornefeld, Andreas Kolk
BACKGROUND: Graves' disease is a common autoimmune inflammatory condition of the thyroid. About one in four of affected patients also develop orbital symptoms like exophthalmos, proptosis and diplopia - called Graves' Ophthalmopathy. Not all patients respond well to the standard therapy of systemic glucocorticoid administration. The inflammatory swelling of the intraorbital muscles can lead to pressure-induced damage of the optic nerve. Orbital decompression surgery is a therapeutic option for these patients with varying success...
February 27, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29465483/case-series-noninflammatory-thyroid-eye-disease
#10
Shoaib Ugradar, Daniel B Rootman
PURPOSE: Patients presenting with thyroid eye disease (TED) usually follow a well-defined self-remitting course characterized by an active inflammatory phase followed by an inactive fibrotic phase. We present 3 cases where patients presented primarily with signs of progressive fibrosis and no signs of prior active inflammation. METHODS: We reviewed the clinical notes and investigations of 3 patients who presented to our center between January 2015 and August 2017...
February 16, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29465482/soft-tissue-metrics-in-thyroid-eye-disease-an-international-thyroid-eye-disease-society-reliability-study
#11
Louise A Mawn, Peter J Dolman, Michael Kazim, Diego Strianese, Ignacio Genol, Kelvin K L Chong, Timothy J Sullivan, Bobby S Korn, Milind Naik, Jonathan Dutton, Augusto Velasco E Cruz, Chun Li
PURPOSE: To determine the reliability of 3 scales for assessing soft tissue inflammatory and congestive signs associated with thyroid eye disease. METHODS: This was a multicentered prospective observational study, recruiting 55 adults with thyroid eye disease from 9 international centers. Six thyroid eye disease soft tissue features were measured; each sign graded using 3 scales (presence/absence [0-1], 3-point scale [0-2], and percentage [0-100]). Each eye was graded twice by 2 independent raters...
February 16, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29426788/approach-to-a-patient-with-diplopia-in-the-emergency-department
#12
Edward Margolin, Cindy T Y Lam
BACKGROUND: Diplopia can be the result of benign or life-threatening etiologies. It is imperative for the emergency physician to be proficient at assessing diplopia and recognize when urgent referral or neuroimaging is required. OBJECTIVE: The first part of this review highlights a simple framework to arrive at the appropriate disposition of diplopic patients presenting to the emergency department (ED). The second part of this review provides more detail and further management strategies...
February 6, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29422752/epidemiology-and-clinical-features-of-thyroid-associated-orbitopathy-in-accra
#13
Edith Mawunyo Ackuaku-Dogbe, Josephine Akpalu, Benjamin Abaidoo
PURPOSE: Thyroid-associated orbitopathy (TAO), a clinical manifestation of Graves' disease, is an autoimmune disorder of the orbital and periorbital tissue. Data on the epidemiology and clinical presentation of TAO in Africa are generally scarce and unavailable in Ghana. We investigated the epidemiology and clinical features of TAO among patients with thyroid disorders attending the Korle Bu Teaching Hospital, Accra. SUBJECTS AND METHODS: This was a descriptive cross-sectional study of patients diagnosed with thyroid disorders which was conducted at the endocrine and orbital clinics of the Korle Bu Teaching Hospital...
October 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/29421653/modulation-of-hyaluronan-polymer-size-regulates-proliferation-of-perimysial-fibroblasts-in-thyroid-eye-disease
#14
Ruiqi Ma, Qian Li, Zhongfeng Wang, Yifei Yuan, Lu Gan, Jiang Qian
In active thyroid eye disease (TED), the extraocular muscles feature excessive hyaluronan (HA) accumulation and increased fibroblast proliferation. To investigate the effects of HA on proliferation, we cultured perimysial fibroblasts from extraocular muscles of active TED patients, and adopted IGF-1 and PH20 as modulators for HA concentration and HA polymer size. Based on the results, IGF-1 increased HA concentration, promoted high molecular weight HA (HMW-HA) proportion and stimulated fibroblast proliferation...
February 19, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29409479/orbital-radiotherapy-plus-three-wall-orbital-decompression-in-a-patient-with-rare-ocular-manifestations-of-thyroid-eye-disease-case-report
#15
Shuo Zhang, Yang Wang, Sisi Zhong, Xingtong Liu, Yazhuo Huang, Sijie Fang, Ai Zhuang, Yinwei Li, Jing Sun, Huifang Zhou, Xianqun Fan
BACKGROUND: Thyroid eye disease (TED) is a debilitating autoimmune orbital disease that is often a result of Graves' disease. Dysthyroid optic neuropathy (DON) is a rare but sight-threatening manifestation of TED with therapeutic challenges that can potentially lead to visual loss. CASE PRESENTATION: A 74-year-old man experienced active TED with extremely severe redness and swelling of the conjunctiva, loss of visual acuity and exacerbation of disfiguring proptosis...
February 6, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29407441/thyroid-hormone-signaling-in-retinal-development-survival-and-disease
#16
Fan Yang, Hongwei Ma, Xi-Qin Ding
Thyroid hormone (TH) is essential in numerous physiological functions and developmental processes. It acts through TH receptors (TRs) to regulate gene expression. The retina is the light-sensitive tissue lining the back of the eye and functions as the first step of the visual process. Rod and cone photoreceptors are specialized sensory neurons in the retina that initiate phototransduction. Rods are responsible for dim light vision, whereas cones are responsible for daytime vision, color vision, and visual acuity...
2018: Vitamins and Hormones
https://www.readbyqxmd.com/read/29396245/combined-immunosuppression-and-radiotherapy-in-thyroid-eye-disease-cirted-a-multicentre-2-%C3%A3-2-factorial-double-blind-randomised-controlled-trial
#17
Rathie Rajendram, Peter N Taylor, Victoria J Wilson, Nicola Harris, Olivia C Morris, Marjorie Tomlinson, Sue Yarrow, Helen Garrott, Helen M Herbert, Andrew D Dick, Anne Cook, Rao Gattamaneni, Rajni Jain, Jane Olver, Steven J Hurel, Fion Bremner, Suzannah R Drummond, Ewan Kemp, Diana M Ritchie, Nichola Rumsey, Daniel Morris, Carol Lane, Nachi Palaniappan, Chunhei Li, Julie Pell, Robert Hills, Daniel G Ezra, Mike J Potts, Sue Jackson, Geoffrey E Rose, Nicholas Plowman, Catey Bunce, Jimmy M Uddin, Richard W J Lee, Colin M Dayan
BACKGROUND: Standard treatment for thyroid eye disease is with systemic corticosteroids. We aimed to establish whether orbital radiotherapy or antiproliferative immunosuppression would confer any additional benefit. METHODS: CIRTED was a multicentre, double-blind, randomised controlled trial with a 2 × 2 factorial design done at six centres in the UK. Adults with active moderate-to-severe thyroid eye disease associated with proptosis or ocular motility restriction were recruited to the trial...
April 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29377729/computed-tomography-measurements-as-a-standard-of-exophthalmos-two-dimensional-versus-three-dimensional-techniques
#18
Jie Guo, Jiang Qian, Yifei Yuan
PURPOSE: To compare measurements of exophthalmos using two-dimensional (2D) and three-dimensional (3D) computed tomography (CT) methods. METHODS: The CT data of 50 patients with thyroid eye disease were collected. The exophthalmos measurements were performed using both 2D and 3D methods. The protrusion of the globe center, the deviation angle of the ocular axis, and the distance between the globe center and the corneal apex were also recorded. The agreements between Hertel exophthalmometry and different CT measurements were analyzed, and the geometrical relationship between the protrusion of the corneal apex and globe center were analyzed...
January 29, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29373659/simultaneous-aesthetic-eyelid-surgery-and-orbital-decompression-for-rehabilitation-of-thyroid-eye-disease-the-one-stage-approach
#19
Francesco P Bernardini, Brent Skippen, Alessandra Zambelli, Benjamin Riesco, Martin H Devoto
Background: Aesthetic rehabilitation of thyroid orbitopathy includes orbital decompression, correction of eyelid retraction and aesthetic blepharoplasty, performed traditionally in separate stages. Objectives: To report the results of orbital decompression surgery associated with aesthetic eyelid surgery in one stage for aesthetic rehabilitation of patients affected by thyroid eye disease. Methods: Retrospective, multi centric study including 40 consecutive patients, who underwent orbital decompression surgery associated with aesthetic eyelid surgery in two centers: Genova (Group 1) + Buenos Aires (Group 2)...
January 24, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29373405/bony-regrowth-after-deep-lateral-orbital-decompression
#20
Sathyadeepak Ramesh, Knut Eichhorn, Steven Leibowitz, Robert Goldberg
PURPOSE: To report on 2 cases of late bony regrowth with clinically apparent proptosis after deep lateral orbital decompression for thyroid orbitopathy. METHODS: A retrospective review of 2 cases identified by the authors as having late bony regrowth. The authors review the clinical, historical, radiologic, and anatomical findings and discuss the significance thereof. RESULTS: Bony regrowth with bowing toward the middle cranial fossa is observed at postoperative month 8 in the first case...
January 25, 2018: Ophthalmic Plastic and Reconstructive Surgery
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