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Thyroid eye disease

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https://www.readbyqxmd.com/read/28975236/gene-expression-profiling-and-heterogeneity-of-nonspecific-orbital-inflammation-affecting-the-lacrimal-gland
#1
James T Rosenbaum, Dongseok Choi, Christina A Harrington, David J Wilson, Hans E Grossniklaus, Cailin H Sibley, Sherveen S Salek, John D Ng, Roger A Dailey, Eric A Steele, Brent Hayek, Caroline M Craven, Deepak P Edward, Azza M Y Maktabi, Hailah Al Hussain, Valerie A White, Peter J Dolman, Craig N Czyz, Jill A Foster, Gerald J Harris, Youn-Shen Bee, David T Tse, Chrisfouad R Alabiad, Sander R Dubovy, Michael Kazim, Dinesh Selva, R Patrick Yeatts, Bobby S Korn, Don O Kikkawa, Rona Z Silkiss, Jennifer A Sivak-Callcott, Patrick Stauffer, Stephen R Planck
Importance: Although a variety of well-characterized diseases, such as sarcoidosis and granulomatosis with polyangiitis, affect the lacrimal gland, many patients with dacryoadenitis are diagnosed as having nonspecific orbital inflammation (NSOI) on the basis of histology and systemic disease evaluation. The ability to further classify the disease in these patients should facilitate selection of effective therapies. Objective: To test the a priori hypothesis that gene expression profiles would complement clinical and histopathologic evaluations in identifying well-characterized diseases and in subdividing NSOI into clinically relevant groups...
September 21, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28945293/correlation-among-ocular-surface-disease-xerostomia-and-nasal-symptoms-in-patients-with-differentiated-thyroid-carcinoma-subjected-to-radioiodine-therapy-a-prospective-comparative-study
#2
Fabricio Lopes da Fonseca, Patricia Kazue Yamanaka, Luciana Mazoti, Lica Arakawa-Sugueno, Juliana Mika Kato, Suzana Matayoshi
BACKGROUND: Some complications of radioiodine therapy have been reported, but the involvement of the eyes and adnexa is rarely discussed. The purpose of this study was to determine the correlation among ocular surface changes, xerostomia, and changes in the nasal mucosa associated with radioiodine therapy. METHODS: Patients subjected to radioiodine therapy (group 1) or not subjected (group 2) were prospectively evaluated by examinations of the ocular surface and tear film, saliva production, and nasal endoscopy...
September 25, 2017: Head & Neck
https://www.readbyqxmd.com/read/28944477/long-term-impact-of-endoscopic-orbital-decompression-on-sinonasal-specific-quality-of-life
#3
Sarina K Mueller, Marcel M Miyake, Daniel R Lefebvre, Suzanne K Freitag, Benjamin S Bleier
OBJECTIVE: Endoscopic orbital decompression (EOD) is the workhorse surgical intervention for severe thyroid eye disease in Graves disease. Although EOD is a safe and effective procedure. The objective of this study is to determine the impact of orbital decompression on long-term sinonasal-specific quality of life. METHODS: Retrospective study of 27 patients who underwent EOD by a single surgeon. The primary endpoint was change in preoperative 22-item Sinonasal Outcomes Test (SNOT-22) score at a minimum of 1 year...
September 25, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28944001/recurrent-graves-hyperthyroidism-after-prolonged-radioiodine-induced-hypothyroidism
#4
REVIEW
Fariha Salman, Hooman Oktaei, Solomon Solomon, Ebenezer Nyenwe
BACKGROUND: Radioactive iodine (RAI) is the most cost effective therapy for Graves' disease (GD). Patients with GD who have become hypothyroid after therapeutic RAI, rarely develop recurrence of disease. Herein we describe a case of recurrence of thyrotoxicosis after 2 years of hypothyroidism. METHODS: We present the clinical features, laboratory findings, imaging and management of an unusual case of recurrent hyperthyroidism. RESULTS: A 48-year-old male presented to the emergency room with a 2-day history of palpitation, chest discomfort and 30 pounds of weight loss...
July 2017: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28937496/characterizing-intraorbital-optic-nerve-changes-on-diffusion-tensor-imaging-in-thyroid-eye-disease-before-dysthyroid-optic-neuropathy
#5
Hwa Lee, Young Hen Lee, Sang-Il Suh, Eun-Kee Jeong, Sehyun Baek, Hyung Suk Seo
OBJECTIVE: The aim of this study was to determine whether the optic nerve is affected by thyroid eye disease (TED) before the development of dysthyroid optic neuropathy with diffusion-tensor imaging (DTI). METHODS: Twenty TED patients and 20 controls were included. The mean, axial, and radial diffusivities and fractional anisotropy (FA) value were measured at the optic nerves in DTI. Extraocular muscle diameters were measured on computed tomography. The diffusivities and FA of the optic nerves were compared between TED and controls and between active and inactive stages of TED...
September 20, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28936049/prevalence-and-risk-factors-of-dry-eye-symptoms-in-a-saudi-arabian-population
#6
Abdulaziz A Alshamrani, Abdulwahab S Almousa, Abdulrahman A Almulhim, Abdullah A Alafaleq, Mohammed B Alosaimi, Abdulrahman M Alqahtani, Ammar M Almulhem, Mohammed A Alshamrani, Ahmad H Alhallafi, Ismail Z Alqahtani, Abdullah A Alshehri
BACKGROUND: The information about dry eye epidemiology in Saudi Arabia is few in literature. PURPOSE: To estimate the prevalence and identify determinants of dry eye symptoms (DES) in Al-Ahsa, Saudi Arabia. METHODS: Using a multi-stage proportionate sampling technique, Saudis of both genders from 6 urban and 4 rural Primary Health Care centers in Al-Ahsa were enrolled. They were interviewed to gather data on sociodemography, symptoms of dry eye, factors potentially related to dry eye, and chronic comorbidities...
April 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28887209/thyroid-associated-orbitopathy-and-tears-a-proteomics-study
#7
Edina Kishazi, Marianne Dor, Simone Eperon, Aurélie Oberic, Mehrad Hamedani, Natacha Turck
To date, Thyroid-Associated Orbitopathy (TAO), an autoimmune inflammatory disease affecting the eye, remains poorly characterised and its diagnosis challenging. The aim of this study was to investigate the tears of the TAO patients in order to identify potential biomarkers. Two independent quantitative Tandem Mass Tag™ 6-plex experiments were done. After in-solution digestion and isoelectric fractionation, the 12 fractions were analysed with a LTQ Orbitrap Velos coupled to a liquid chromatography. Raw files were searched against Swiss-Prot-AC database using Proteome Discoverer software, with a false discovery rate of 1% at peptide and protein levels...
September 5, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28871668/retina-and-nerve-fiber-layer-thickness-in-eyes-with-thyroid-associated-ophthalmopathy
#8
Sharon Blum Meirovitch, Igal Leibovitch, Anat Kesler, David Varssano, Amir Rosenblatt, Meira Neudorfer
BACKGROUND: Thyroid-associated ophthalmopathy (TAO) is an inflammatory disease that affects the thyroid gland and the eye orbit. Of patients with TAO, 3%-5% have severe sight-threatening disease due to optic neuropathy Optical coherence tomography (OCT), the non-invasive imaging technology that yields high-resolution cross-sectional images of the retina, provides qualitative and quantitative data on the retina. OBJECTIVES: To apply this technique to quantitatively assess retinal nerve fiber layer (RNFL) and macular ring thicknesses in healthy subjects and in patients with TAO to determine their relationship to the severity of the orbital disease...
May 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28822031/advances-in-the-management-of-thyroid-eye-diseases-an-overview
#9
REVIEW
Rashmi Kumari, Bhawesh Chandra Saha
INTRODUCTION: Thyroid eye disease (TED) remains a notorious ailment for both patients and the treating ophthalmologists. Recent years have witnessed considerable research in the immunopathogenic mechanism of TED that has resulted in an expansion and modification of the available management options. AIM: Purpose of this review is to summarise the advances in the management of thyroid ophthalmopathy. MATERIAL AND METHOD: A thorough literature search and of the past 10 years web search with words Thyroid ophthalmopathy, recent, advances...
August 18, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28812921/a-case-of-concurrent-silent-sinus-syndrome-thyroid-eye-disease-idiopathic-orbital-inflammatory-syndrome-and-dacryoadenitis
#10
Wen-Shi Shieh, Alison B Huggins, Mindy R Rabinowitz, Marc R Rosen, Michael P Rabinowitz
This is a retrospective case description of a single female patient found to have concomitant bilateral silent sinus syndrome, bilateral thyroid eye disease, unilateral dacryoadenitis, and idiopathic orbital inflammation that presented as progressive unilateral right-sided proptosis. The spectrum of inflammatory orbital diseases can make discerning between different entities challenging, but more unique in this case was the simultaneous presentation with bilateral silent sinus syndrome, a rare entity in its own right...
August 16, 2017: Orbit
https://www.readbyqxmd.com/read/28794075/non-surgical-treatment-for-eyelid-retraction-in-thyroid-eye-disease-ted
#11
REVIEW
Ana Beatriz Diniz Grisolia, Ricardo Christopher Couso, Suzana Matayoshi, Raymond S Douglas, César Augusto Briceño
Thyroid eye disease (TED) is an autoimmune condition with an unpredictable course that may lead to permanent facial disfigurement. Eyelid retraction is one of the most common findings, and frequently demands attention due to ocular exposure and impaired cosmesis. Surgical treatment remains the most effective option, but there is a role for temporary corrections during the active phase of the disease, as well as in patients who are poor surgical candidates. The aim of this review is to describe the non-surgical modalities currently available for treatment of eyelid malposition in TED...
August 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28770897/typical-graves-ophthalmopathy-in-primary-hypothyroidism
#12
Zareen Kiran, Owais Rashid, Najmul Islam
Graves ophthalmopathy (GO) usually occurs in a close temporal relationship with hyperthyroidism. It is rare in patients with normal thyroid function (euthyroid GO) and in patients with hypothyroid forms of thyroid autoimmune diseases (hypothyroid GO). We report a 52-years old man presenting in our endocrine clinic with diagnosed primary hypothyroidism 3 months back during evaluation for glaucoma. He was later referred by an ophthalmologist to exclude Grave's eye disease, where he had presented with chief complaints of bilateral prominent eyes...
July 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28750432/hyperthyroidism-in-patients-with-graves-ophthalmopathy-and-thyroidal-skeletal-and-eye-muscle-specific-type-2-deiodinase-enzyme-activities
#13
Ildikó Molnár, József A Szentmiklósi, Éva Somogyiné-Vári
Graves' ophthalmopathy is characterized by hyperthyroidism, which is associated with higher serum T3 levels than T4 due to deiodinase enzymes.The effect of Graves' patient's sera (n=52) with elevated thyroid hormone and TSH receptor or thyroid peroxidase antibody (anti-TPO) levels was investigated on thyroidal, skeletal and eye muscle type 2 deiodinase enzyme (DII) activities. DII activities were measured with (125)I-T4 substrate, while thyroid hormone and antibody levels with immunoassays.In Graves' ophthalmopathy, sera with elevated FT4 or FT3 levels reduced DII activites remarkably in all tissue fractions...
September 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28748990/-clinical-features-of-patients-with-basedow-graves-disease-seen-at-a-university-hospital
#14
Alejandra Lanas, Patricia Díaz, Daniela Eugenin, Franco González, Pía Cid, Francisco Cordero, Verónica Araya, Claudio Liberman, Marcela Barberan, Patricio Gac, Neil Saldías, Pedro Pineda
BACKGROUND: Basedow Graves disease (BGD) is the leading cause of hyperthyroidism. The characteristics of patients seen at a university hospital may differ from those described in the general population. AIM: To describe the clinical features of patients with BGD seen at a university hospital. MATERIAL AND METHODS: Review of medical records of all patients seen at our hospital between 2009 and 2014 with the diagnosis of thyrotoxicosis, hyperthyroidism or BGD...
April 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28738723/patients-expectations-for-the-functional-and-psychosocial-outcomes-of-orbital-decompression-surgery-for-thyroid-eye-disease-a-qualitative-study
#15
Sadie Wickwar, Hayley McBain, Matthew R Edmunds, Daniel G Ezra, Geoffrey E Rose, Stanton P Newman
Patients with appearance-altering conditions may be dissatisfied with the outcomes of reconstructive surgery due to unmet expectations. This study explored patients' expectations of orbital decompression surgery for thyroid eye disease (TED) and whether these were met. Semi-structured interviews were conducted at two times: (1) in the weeks after patients were listed for decompression surgery and before surgery; (2) up to 12 months after surgery. Thematic analysis was performed for each time point, to identify themes within the data...
July 25, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28736474/phenotype-analysis-of-early-risk-factors-from-electronic-medical-records-improves-image-derived-diagnostic-classifiers-for-optic-nerve-pathology
#16
Shikha Chaganti, Kunal P Nabar, Katrina M Nelson, Louise A Mawn, Bennett A Landman
We examine imaging and electronic medical records (EMR) of 588 subjects over five major disease groups that affect optic nerve function. An objective evaluation of the role of imaging and EMR data in diagnosis of these conditions would improve understanding of these diseases and help in early intervention. We developed an automated image-processing pipeline that identifies the orbital structures within the human eyes from computed tomography (CT) scans, calculates structural size, and performs volume measurements...
February 11, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28736470/structural-functional-relationships-between-eye-orbital-imaging-biomarkers-and-clinical-visual-assessments
#17
Xiuya Yao, Shikha Chaganti, Kunal P Nabar, Katrina Nelson, Andrew Plassard, Rob L Harrigan, Louise A Mawn, Bennett A Landman
Eye diseases and visual impairment affect millions of Americans and induce billions of dollars in annual economic burdens. Expounding upon existing knowledge of eye diseases could lead to improved treatment and disease prevention. This research investigated the relationship between structural metrics of the eye orbit and visual function measurements in a cohort of 470 patients from a retrospective study of ophthalmology records for patients (with thyroid eye disease, orbital inflammation, optic nerve edema, glaucoma, intrinsic optic nerve disease), clinical imaging, and visual function assessments...
February 11, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28727542/single-session-high-intensity-focused-ultrasound-treatment-for-persistent-or-relapsed-graves-disease-preliminary-experience-in-a-prospective-study
#18
Brian Hung-Hin Lang, Yu-Cho Woo, Ian Yat-Hin Wong, Keith Wan-Hang Chiu
Purpose To evaluate the safety and efficacy of ultrasonography (US)-guided high-intensity focused ultrasound (HIFU) ablation as a treatment for medically refractory Graves disease (GD). Materials and Methods After ethics approval, a prospective trial (NCT02685514) was performed from November 2015 to February 2016. Thirty patients underwent ablation of the entire right and left thyroid lobes, with areas near the tracheal-esophageal groove and common carotid artery left unablated. Serum thyroid-stimulating hormone (TSH), free T4 (FT4), antithyroid autoantibodies, and TSH receptor (TSHR) antibody levels were evaluated afterward, and US color Doppler, US volumetry, and eye assessment were performed...
July 20, 2017: Radiology
https://www.readbyqxmd.com/read/28711580/lateral-rectus-muscle-resection-following-maximal-recession-of-the-medial-rectus-muscle-in-thyroid-eye-disease
#19
Eric Weldy, Natalie C Kerr
BACKGROUND: Rectus muscle restriction is a common finding in thyroid eye disease (TED). Typically, restricted muscles are recessed to address strabismus and diplopia. However, some patients have residual strabismus following maximal recession of a restricted muscle. The purpose of this study was to report outcomes following resection of the lateral rectus muscle after maximal recession of the medial rectus muscle in patients with TED. METHODS: The medical records of patients with TED who underwent lateral rectus resection between 1998 and 2015 were reviewed retrospectively...
July 12, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28700384/update-on-graves-disease-advances-in-treatment-of-mild-moderate-and-severe-thyroid-eye-disease
#20
REVIEW
Diego Strianese
PURPOSE OF REVIEW: To report the most recent therapeutic advances of thyroid eye disease (TED) and offer general recommendations for management of TED. RECENT FINDINGS: Treatment of Graves ophthalmopathy is traditionally based on the use of high doses of corticosteroids and/or radiotherapy (RT) to decrease the activity of the disease, with the subsequent proptosis, strabismus and eyelid deformites treated with different surgical procedures. In recent years, the evidence that oxidative stress plays a relevant role in exacerbating TED severity has encouraged the use of antioxydative agents such as selenium, which has shown a capacity in limiting the disease progression...
September 2017: Current Opinion in Ophthalmology
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