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Thyroid eye disease

Zdeněk Fryšák, David Karásek, Milan Halenka
Endocrine orbitopathy (EO) must be understood mainly as a result of oxidative stress. The pathological process finally affects both the appearance and vision of the patient. In the case of inappropriate or late treatment or lack of patient cooperation, it significantly influences the quality of life of those affected. In spite of the sophisticated dia-gnostic algorithms, in some cases it is difficult to confirm the diagnosis of EO. The range of laboratory methods, the essential part of the diagnostic process, has only recently been extended by the possibility of quantification of specific, stimulating immunoglobulins (TSI)...
2016: Vnitr̆ní Lékar̆ství
S L Hsu, P Y Lee, C H Chang, C H Chen
Thyroid orbitopathy (TO) is an autoimmune disease that is complicated by ocular surface disorders, leading to discomfort. Dry eye is very prevalent in patients with TO. Recent studies on the pathogenesis of dry eye have focused on the inflammatory process, and some supporting evidence has been discovered. Because TO is a disorder of autoimmune origin, we assumed that the association between TO and dry eye is related to inflammation. Inflammation of the ocular surface in TO-related dry eye has not been well studied...
August 30, 2016: Genetics and Molecular Research: GMR
Danielle L Weiler
Thyroid eye disease is a multifactorial autoimmune disease with a spectrum of signs and symptoms. Oftentimes, the diagnosis of thyroid eye disease is straightforward, based upon history and physical examination. The purpose of this review is to assist the eye-care practitioner in staging the severity of thyroid eye disease (mild, moderate-to-severe and sight-threatening) and correlating available treatment modalities. Eye-care practitioners play an important role in the multidisciplinary team by assessing functional vision while also managing ocular health...
October 4, 2016: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
Justyna Szczapa-Jagustyn, Anna Gotz-Więckowska, Jarosław Kocięcki
BACKGROUND: Risk of developing thyroid-associated ophthalmopathy (TAO) in children and adolescents is similar or may be even slightly higher than in adults. The aim of this article is to review and summarize current knowledge regarding diagnostic and therapeutic measures in pediatric TAO. CONTENT: MEDLINE and EMBASE papers were searched using the terms 'pediatric Graves' ophthalmopathy' 'pediatric Graves' orbitopathy', 'thyroid-associated ophthalmopathy in childhood and adolescence' from the year 1970 to December 2015...
October 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
Elisabeth M Messmer, Victoria von Lindenfels, Alexandra Garbe, Anselm Kampik
PURPOSE: To measure matrix metalloproteinase 9 (MMP-9) in the tear film of patients with dry eye disease (DED) compared with controls and to correlate clinical findings. DESIGN: In a prospective study, 101 patients and controls underwent MMP-9 testing of the tear film. Thereafter, they were evaluated for symptoms and signs of DED. PARTICIPANTS: Included patients were those who showed 3 of the following 4 dry eye criteria: ocular surface disease index (OSDI) score of more than 12, tear film break-up time (TBUT) of 10 seconds or less, Schirmer test results without anesthesia of less than 10 mm/5 minutes, and corneal staining results of 1 or more...
September 21, 2016: Ophthalmology
P Anagnostis, K Boboridis, F Adamidou, M Kita
BACKGROUND/AIMS: The natural course of Graves' orbitopathy (GO) has been poorly documented. The aim of this review is to provide current knowledge regarding the natural course of mild GO, trying to address the issue of whether and to what extent it constitutes a chronic remitting or transient disease. METHODS: We systematically searched PubMed for English language publications until August 2016 under the following terms: "Graves' orbitopathy" OR "Graves' ophthalmopathy" OR "thyroid eye disease" AND "natural course" OR "natural history"...
September 23, 2016: Journal of Endocrinological Investigation
Jasleen Singh, Catherine S Choi, Reecha Bahl, Steven M Archer
PURPOSE: To evaluate the effectiveness of the partial tendon recession procedure in correcting small-angle vertical deviations. METHODS: The medical records of patients who underwent partial tendon recession (one pole) were reviewed retrospectively. Orthophoria was the primary outcome success criterion; residual deviation, torsion, and the dose-response relationship were also evaluated. A secondary analysis was performed on subsets of patients with thyroid eye disease (TED) and those with procedures on a muscle that had previous surgery...
September 16, 2016: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Christopher C Gillis, Eun Hae Chang, Khalid Al-Kharazi, Tom Pickles
AIM: To describe the first case of a secondary meningioma in a patient after radiation treatment for thyroid eye disease (TED). Secondarily to identify any additional cases of secondary malignancy resulting from radiotherapy for thyroid eye disease from our institutional experience. BACKGROUND: Thyroid eye disease (TED) is a self-limiting auto-immune disorder causing expansion of orbital soft tissue from deposition of glycosaminoglycans and collagen, leading to significant cosmetic and functional morbidity...
May 2016: Reports of Practical Oncology and Radiotherapy
Ya O Grusha, D S Ismailova, P A Kochetkov, S S Danilov
UNLABELLED: Precise instrument localization is of great importance in orbital decompression surgery. Different navigation systems were designed to fulfill this task and gained wide acceptance. AIM: to describe principal features and determine advantages of intraoperatively navigated orbital bony decompression. MATERIAL AND METHODS: Data on orbital decompression surgery performed with or without intraoperative image guidance is presented. Each time two surgeons were involved - an ophthalmologist (lateral wall decompression) and otolaryngologist (medial wall decompression)...
July 2016: Vestnik Oftalmologii
Tessa Fayers, Peter M Fayers, Peter J Dolman
We tested the sensitivity and responsiveness of the TED-QOL to rehabilitative surgery in thyroid eye disease (TED). The 3-item TED-QOL and 16-item GO-QOL, which assess quality of life (QoL) in TED, were administered to consecutive patients undergoing rehabilitative surgery. The questionnaires were completed pre-and post-operatively to assess sensitivity (ability to discriminate between different surgical groups) and responsiveness (ability to detect within patient changes over time).56 patients underwent 69 procedures for TED (29 orbital decompressions, 15 strabismus operations, 25 eyelid procedures)...
September 6, 2016: Orbit
Mehryar Ray Taban
BACKGROUND: Internal eyelid spacer graft is routinely placed during lower eyelid retraction surgery, which may be unnecessary. OBJECTIVES: To evaluate the efficacy of lower eyelid retraction surgery without internal graft in select cases. METHODS: Retrospective analysis of patients undergoing reconstructive lower eyelid retraction surgery without internal graft, by one surgeon from 2013 to 2015. Surgical technique included transconjunctival lower eyelid retractor lysis, canthoplasty, and temporary tarsorrhaphy, with or without subperiosteal midface-sub oribularis oculi fat (SOOF) lifting and scar lysis...
September 2, 2016: Aesthetic Surgery Journal
Shani Golan, Dan B Rootman, Robert A Goldberg
Although reoperation rates for upper lid retraction surgery for thyroid eye disease (TED) typically range between 8% and 23%, there is little literature describing the outcomes of these second operations. In this retrospective observational cohort study, all patients that underwent surgery for upper eyelid retraction over a 14-year period at a single institution were included. Cases were included if a second eyelid retraction surgery was performed during the study period. Success of surgery was defined as a marginal reflex distance (MRD1) of 2...
August 25, 2016: Orbit
Flavia Magri, Francesca Zerbini, Margherita Gaiti, Valentina Capelli, Alberto Ragni, Mario Rotondi, Luca Chiovato
: Objective The outcome of anti-thyroid drugs (ATD) treatment for Graves' disease (GD) is difficult to be predicted. In this study we investigated whether male gender, besides other factors usually associated with a poor outcome of ATD treatment, may affect disease presentation and predict the response to medical treatment in subjects with GD. METHODS: We studied 294 patients with a first diagnosis of GD. In all patients, ATD treatment was started. Clinical features, thyroid volume and eye involvement were recorded at baseline...
August 19, 2016: Endocrine Practice
A Sadeghi-Tari, M Jamshidian-Tehrani, A Nabavi, S Sharif-Kashani, E Elhami, N Hassanpour, K Ameli Zamani
PurposeTo evaluate the effect of smoking on retrobulbar blood flow parameters by color Doppler imaging in patients with thyroid eye disease.Patients and methodsIn this observational case series, blood flow parameters in the ophthalmic artery, superior ophthalmic vein, central retinal artery, and vein were determined by color Doppler imaging in patients with thyroid eye disease. Patients were grouped as smokers and non-smokers. Never smokers and those who had stopped smoking for at least 1 year before onset of ophthalmopathy were considered as non-smokers...
August 19, 2016: Eye
Mahmoud F El-Sahn, David B Granet, Amir Marvasti, Adele Roa, Michael Kinori
PURPOSE: To describe the epidemiology of adult strabismus, its etiology, and treatment methods in patients 60 years and older presenting to a tertiary care center. METHODS: This retrospective chart review study of patients with strabismus was performed at the Ratner Eye Center, University of California-San Diego. Data collected included demographics, etiology of misalignment, alignment in the primary position, binocularity, previous surgical intervention, and treatment methods...
August 18, 2016: Journal of Pediatric Ophthalmology and Strabismus
Jessica Hookham, Emma E Collins, Amit Allahabadia, Sabapathy P Balasubramanian
BACKGROUND: Graves' disease can be treated with antithyroid drugs (ATDs), radioiodine or surgery. Use of definitive treatments (radioiodine or surgery) varies widely across centres. Specific clinical circumstances, local facilities, patient and clinician preferences and perceptions will affect the choice of treatment. Detailed understanding of UK clinicians' views and their rationale for different treatments is lacking. AIMS: To study the preferences and perceptions of UK clinicians on the role of surgery and radioiodine in the management of Graves' disease...
August 16, 2016: Postgraduate Medical Journal
Sarah C Xu, Angela C Gauthier, Ji Liu
Glaucoma is one of the leading causes of blindness worldwide. Recent studies suggest that intraocular pressure (IOP) fluctuations, peaks, and rhythm are important factors in disease advancement. Yet, current glaucoma management remains hinged on single IOP measurements during clinic hours. To overcome this limitation, 24-hour IOP monitoring devices have been employed and include self-tonometry, permanent IOP, and temporary IOP monitoring. This review discusses each IOP measuring strategy and focuses on the recently FDA-approved contact lens sensor (CLS)...
2016: Journal of Ophthalmology
Michelle E Wilson, Charles Kim, Jacqueline Carrasco
A 48-year-old smoker with a history of hyperthyroidism treated 10 years prior to presentation with radioactive iodine ablation of the thyroid gland presented to his ophthalmologist with a 2-week history of transient loss of vision in the right eye occurring for 1 to 2 hours each morning. He denied ocular pain, diplopia or change in the prominence of one or both eyes. Examination revealed 2 mm of relative proptosis on the right, bilateral temporal flare and lower lid retraction. There was minimal upper lid retraction and no evidence of lid lag...
October 2016: Orbit
Yasuhiro Takahashi, Yoshiyuki Kitaguchi, Shunsuke Nakakura, Hidenori Mito, Akiko Kimura, Hirohiko Kakizaki
PURPOSE: To examine the characteristics of excyclotropia correction through surgery on the inferior rectus muscle in patients with thyroid eye disease. METHODS: This was a retrospective, observational study at a single institution. We reviewed 36 patients who had undergone unilateral inferior rectus muscle recession, with or without nasal inferior rectus muscle transposition. The following factors were investigated as possibly influencing excyclotropia correction: inferior rectus muscle thickness, degree of adipose change in the inferior rectus muscle, smoking status, history of orbital radiotherapy, and the amount of inferior rectus muscle recession...
2016: PloS One
Lindsay L Wong, Nahyoung Grace Lee, Dhanesh Amarnani, Catherine J Choi, Diane R Bielenberg, Suzanne K Freitag, Patricia A D'Amore, Leo A Kim
PURPOSE: The human orbit is an environment that is vulnerable to inflammation and edema in the setting of autoimmune thyroid disease. Our study investigated the tenet that orbital adipose tissue lacks lymphatic vessels and analyzed the clinicopathologic differences between patients with acute and chronic thyroid eye disease (TED). The underlying molecular mediators of blood and lymphatic vessel formation within the orbital fat also were evaluated. DESIGN: Retrospective cohort study...
September 2016: Ophthalmology
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