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Thyroid eye disease

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https://www.readbyqxmd.com/read/29426788/approach-to-a-patient-with-diplopia-in-the-emergency-department
#1
Edward Margolin, Cindy T Y Lam
BACKGROUND: Diplopia can be the result of benign or life-threatening etiologies. It is imperative for the emergency physician to be proficient at assessing diplopia and recognize when urgent referral or neuroimaging is required. OBJECTIVE: The first part of this review highlights a simple framework to arrive at the appropriate disposition of diplopic patients presenting to the emergency department (ED). The second part of this review provides more detail and further management strategies...
February 6, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29422752/epidemiology-and-clinical-features-of-thyroid-associated-orbitopathy-in-accra
#2
Edith Mawunyo Ackuaku-Dogbe, Josephine Akpalu, Benjamin Abaidoo
PURPOSE: Thyroid-associated orbitopathy (TAO), a clinical manifestation of Graves' disease, is an autoimmune disorder of the orbital and periorbital tissue. Data on the epidemiology and clinical presentation of TAO in Africa are generally scarce and unavailable in Ghana. We investigated the epidemiology and clinical features of TAO among patients with thyroid disorders attending the Korle Bu Teaching Hospital, Accra. SUBJECTS AND METHODS: This was a descriptive cross-sectional study of patients diagnosed with thyroid disorders which was conducted at the endocrine and orbital clinics of the Korle Bu Teaching Hospital...
October 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/29421653/modulation-of-hyaluronan-polymer-size-regulates-proliferation-of-perimysial-fibroblasts-in-thyroid-eye-disease
#3
Ruiqi Ma, Qian Li, Zhongfeng Wang, Yifei Yuan, Lu Gan, Jiang Qian
In active thyroid eye disease (TED), the extraocular muscles feature excessive hyaluronan (HA) accumulation and increased fibroblast proliferation. To investigate the effects of HA on proliferation, we cultured perimysial fibroblasts from extraocular muscles of active TED patients, and adopted IGF-1 and PH20 as modulators for HA concentration and HA polymer size. Based on the results, IGF-1 increased HA concentration, promoted high molecular weight HA (HMW-HA) proportion and stimulated fibroblast proliferation...
February 19, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29409479/orbital-radiotherapy-plus-three-wall-orbital-decompression-in-a-patient-with-rare-ocular-manifestations-of-thyroid-eye-disease-case-report
#4
Shuo Zhang, Yang Wang, Sisi Zhong, Xingtong Liu, Yazhuo Huang, Sijie Fang, Ai Zhuang, Yinwei Li, Jing Sun, Huifang Zhou, Xianqun Fan
BACKGROUND: Thyroid eye disease (TED) is a debilitating autoimmune orbital disease that is often a result of Graves' disease. Dysthyroid optic neuropathy (DON) is a rare but sight-threatening manifestation of TED with therapeutic challenges that can potentially lead to visual loss. CASE PRESENTATION: A 74-year-old man experienced active TED with extremely severe redness and swelling of the conjunctiva, loss of visual acuity and exacerbation of disfiguring proptosis...
February 6, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29407441/thyroid-hormone-signaling-in-retinal-development-survival-and-disease
#5
Fan Yang, Hongwei Ma, Xi-Qin Ding
Thyroid hormone (TH) is essential in numerous physiological functions and developmental processes. It acts through TH receptors (TRs) to regulate gene expression. The retina is the light-sensitive tissue lining the back of the eye and functions as the first step of the visual process. Rod and cone photoreceptors are specialized sensory neurons in the retina that initiate phototransduction. Rods are responsible for dim light vision, whereas cones are responsible for daytime vision, color vision, and visual acuity...
2018: Vitamins and Hormones
https://www.readbyqxmd.com/read/29396245/combined-immunosuppression-and-radiotherapy-in-thyroid-eye-disease-cirted-a-multicentre-2%C3%A2-%C3%A3-%C3%A2-2-factorial-double-blind-randomised-controlled-trial
#6
Rathie Rajendram, Peter N Taylor, Victoria J Wilson, Nicola Harris, Olivia C Morris, Marjorie Tomlinson, Sue Yarrow, Helen Garrott, Helen M Herbert, Andrew D Dick, Anne Cook, Rao Gattamaneni, Rajni Jain, Jane Olver, Steven J Hurel, Fion Bremner, Suzannah R Drummond, Ewan Kemp, Diana M Ritchie, Nichola Rumsey, Daniel Morris, Carol Lane, Nachi Palaniappan, Chunhei Li, Julie Pell, Robert Hills, Daniel G Ezra, Mike J Potts, Sue Jackson, Geoffrey E Rose, Nicholas Plowman, Catey Bunce, Jimmy M Uddin, Richard W J Lee, Colin M Dayan
BACKGROUND: Standard treatment for thyroid eye disease is with systemic corticosteroids. We aimed to establish whether orbital radiotherapy or antiproliferative immunosuppression would confer any additional benefit. METHODS: CIRTED was a multicentre, double-blind, randomised controlled trial with a 2 × 2 factorial design done at six centres in the UK. Adults with active moderate-to-severe thyroid eye disease associated with proptosis or ocular motility restriction were recruited to the trial...
January 30, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29377729/computed-tomography-measurements-as-a-standard-of-exophthalmos-two-dimensional-versus-three-dimensional-techniques
#7
Jie Guo, Jiang Qian, Yifei Yuan
PURPOSE: To compare measurements of exophthalmos using two-dimensional (2D) and three-dimensional (3D) computed tomography (CT) methods. METHODS: The CT data of 50 patients with thyroid eye disease were collected. The exophthalmos measurements were performed using both 2D and 3D methods. The protrusion of the globe center, the deviation angle of the ocular axis, and the distance between the globe center and the corneal apex were also recorded. The agreements between Hertel exophthalmometry and different CT measurements were analyzed, and the geometrical relationship between the protrusion of the corneal apex and globe center were analyzed...
January 29, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29373659/simultaneous-aesthetic-eyelid-surgery-and-orbital-decompression-for-rehabilitation-of-thyroid-eye-disease-the-one-stage-approach
#8
Francesco P Bernardini, Brent Skippen, Alessandra Zambelli, Benjamin Riesco, Martin H Devoto
Background: Aesthetic rehabilitation of thyroid orbitopathy includes orbital decompression, correction of eyelid retraction and aesthetic blepharoplasty, performed traditionally in separate stages. Objectives: To report the results of orbital decompression surgery associated with aesthetic eyelid surgery in one stage for aesthetic rehabilitation of patients affected by thyroid eye disease. Methods: Retrospective, multi centric study including 40 consecutive patients, who underwent orbital decompression surgery associated with aesthetic eyelid surgery in two centers: Genova (Group 1) + Buenos Aires (Group 2)...
January 24, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29373405/bony-regrowth-after-deep-lateral-orbital-decompression
#9
Sathyadeepak Ramesh, Knut Eichhorn, Steven Leibowitz, Robert Goldberg
PURPOSE: To report on 2 cases of late bony regrowth with clinically apparent proptosis after deep lateral orbital decompression for thyroid orbitopathy. METHODS: A retrospective review of 2 cases identified by the authors as having late bony regrowth. The authors review the clinical, historical, radiologic, and anatomical findings and discuss the significance thereof. RESULTS: Bony regrowth with bowing toward the middle cranial fossa is observed at postoperative month 8 in the first case...
January 25, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29372654/functional-tsh-receptor-antibodies-in-children-with-autoimmune-thyroid-diseases
#10
Karolina Stożek, Artur Bossowski, Katarzyna Ziora, Anna Bossowska, Małgorzata Mrugacz, Anna Noczyńska, Mieczysław Walczak, Elżbieta Petriczko, Beata Pyrżak, Anna Kucharska, Mieczysław Szalecki, Tanja Diana, George J Kahaly
INTRODUCTION: The diagnostic value of the level of TSH receptor antibodies (TSHR-Ab) in the population of children with autoimmune thyroid diseases (AITDs) is still unknown. The aim of this cross-sectional study was to investigate the prevalence of TSHR-Ab in a paediatric cohort with AITD and healthy controls. MATERIALS AND METHODS: A total of 240 serum samples were obtained from 205 patients with AITD, type 1 diabetes (T1D), juvenile arthritis (JA), and healthy controls (C)...
January 26, 2018: Autoimmunity
https://www.readbyqxmd.com/read/29356717/retrospective-analysis-of-physician-based-surveys-published-in-oprs
#11
Mark A Prendes, Roxana Fu, Isaac W Lamb, William R Nunery, Alon Kahana, H B Harold Lee
PURPOSE: To review physician-based clinical surveys published in Ophthalmic Plastic and Reconstructive Surgery. METHODS: Complementary Ovid and PubMed searches of Ophthalmic Plastic and Reconstructive Surgery journal content were performed for the term "survey." Results were narrowed to studies that specifically addressed physicians' clinical practices. This search resulted in 162 articles, and after dual-investigator independent screening, 13 surveys met inclusion criteria...
January 19, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29329570/exophthalmos-in-a-young-woman-with-no-graves-disease-a-case-report-of-igg4-related-orbitopathy
#12
Annamaria Erdei, Zita Steiber, Csaba Molnar, Ervin Berenyi, Endre V Nagy
BACKGROUND: Immunoglobulin G4-related disease (IgG4-rd) is characterized by lymphoplasmacytic infiltration and tissue fibrosis. Orbital manifestations of IgG4-rd may include unilateral or bilateral proptosis, cicatricial extraocular muscle myopathy, orbital inflammation and pain which may mimic ophthalmic Graves' disease. CASE PRESENTATION: A 25-year-old woman has been referred to the endocrinology clinic, 4 months after delivery, with suspected Graves' orbitopathy...
January 12, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29307273/kikuchi-fujimoto-disease-triggered-by-salmonella-enteritidis-in-a-child-with-concurrent-auto-immune-thyroiditis-and-papilloedema
#13
Esma Altinel Açoğlu, Eyup Sari, Gürses Şahin, Melahat Melek Oğuz, Meltem Akçaboy, Pelin Zorlu, Saliha Senel
Kikuchi-Fujimoto disease (KFD) is a histiocytic necrotising lymphadenitis characterised by painful cervical lymphadenopathy, fever, malaise and weight loss. Infections, auto-immune pathogenesis and a genetic association have been implicated. A 12-year-old boy presented with a 1-month history of fever, abdominal pain, constipation and weight loss, and a painful lymph node was detected in the right axilla. Chest CT demonstrated multiple lymph nodes, especially in the left mediastinum. Salmonella enteritidis group D was detected in a blood culture and he was treated with ceftriaxone, followed by meropenem...
January 8, 2018: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/29288834/exotropia-and-hypotropia-as-the-initial-presentation-sign-of-thyroid-eye-disease-in-an-18-year-old-man
#14
Won Jae Kim, Jun Sung Moon, Myung Mi Kim
Exotropia is rarely reported in thyroid eye disease (TED). We report the case of an 18-year-old patient with TED who developed exotropia and hypotropia as an initial presentation of TED.
December 27, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29273685/igf-i-receptor-and-thyroid-associated-ophthalmopathy
#15
Michelle Mohyi, Terry J Smith
Thyroid-associated ophthalmopathy (TAO) is a vexing and poorly understood autoimmune process involving the upper face and tissues surrounding the eyes. In TAO, the orbit can become inflamed and undergo substantial remodeling that is disfiguring and can lead to loss of vision. These are currently no approved medical therapies for TAO, the consequence of its uncertain pathogenic nature. It usually presents as a component of the syndrome known as Graves' disease where loss of immune tolerance to the thyrotropin receptor (TSHR) results in the generation of activating antibodies against that protein and hyperthyroidism...
December 22, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29260317/effects-of-long-term-cysteamine-treatment-in-patients-with-cystinosis
#16
REVIEW
Gema Ariceta, Vincenzo Giordano, Fernando Santos
Cystinosis is a rare autosomal-recessive lysosomal storage disease with high morbidity and mortality. It is caused by mutations in the CTNS gene that encodes the cystine transporter, cystinosin, which leads to lysosomal cystine accumulation. Patients with infantile nephropathic cystinosis, the most common and most severe clinical form of cystinosis, commonly present with renal Fanconi syndrome by 6-12 months of age, and without specific treatment, almost all will develop end-stage renal disease (ESRD) by 10-12 years of age...
December 19, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29243735/orbital-decompression-for-thyroid-eye-disease-methods-outcomes-and-complications
#17
J M Jefferis, R K Jones, Z I Currie, J H Tan, S M Salvi
PurposeTo determine the safety and effectiveness of orbital decompression for thyroid eye disease (TED) in our unit. To put this in the context of previously published literature.Patients and methodsA retrospective case review of all patients undergoing orbital decompression for TED under the care of one orbital surgeon (SMS) between January 2009 and December 2015. A systematic literature review of orbital decompression for TED.ResultsWithin the reviewed period, 93 orbits of 55 patients underwent decompression surgery for TED...
December 15, 2017: Eye
https://www.readbyqxmd.com/read/29184810/ophthalmic-manifestations-of-endocrine-disorders-endocrinology-and-the-eye
#18
REVIEW
Alisha Kamboj, Michael Lause, Priyanka Kumar
Disorders of the endocrine system usually manifest in a multi-organ fashion. More specifically, many endocrinopathies become apparent in the eye first through a variety of distinct pathophysiologic disturbances. The eye provides physicians with valuable clues for the recognition and management of numerous systemic diseases, including many disorders of the endocrine pathway. Recognizing ophthalmic manifestations of endocrine disorders is critical not only for rapid diagnosis and treatment, but also to prevent significant morbidity and mortality...
October 2017: Translational pediatrics
https://www.readbyqxmd.com/read/29182030/biomarkers-of-ocular-surface-disease-using-impression-cytology
#19
REVIEW
Suzanne Hagan
Impression cytology (IC) is a technique which permits the retrieval of the outermost layer of ocular surface cells via the use of various types of filters. It is a minimally invasive method of evaluating human conjunctival epithelial cell morphology in the diagnosis of dry eye disease, a common and distressing disorder associated with ageing, contact lens wear, autoimmune disorders and refractive (LASIK) surgery. IC may also be utilized in the diagnosis of other ocular diseases, such as keratoconus and thyroid orbitopathy...
December 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29163360/vitiligo-and-autoimmune-thyroid-disorders
#20
REVIEW
Enke Baldini, Teresa Odorisio, Salvatore Sorrenti, Antonio Catania, Francesco Tartaglia, Giovanni Carbotta, Daniele Pironi, Roberta Rendina, Eleonora D'Armiento, Severino Persechino, Salvatore Ulisse
Vitiligo represents the most common cause of acquired skin, hair, and oral depigmentation, affecting 0.5-1% of the population worldwide. It is clinically characterized by the appearance of disfiguring circumscribed skin macules following melanocyte destruction by autoreactive cytotoxic T lymphocytes. Patients affected by vitiligo usually show a poorer quality of life and are more likely to suffer from depressive symptoms, particularly evident in dark-skinned individuals. Although vitiligo is a non-fatal disease, exposure of affected skin to UV light increases the chance of skin irritation and predisposes to skin cancer...
2017: Frontiers in Endocrinology
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