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Thyroid eye disease

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https://www.readbyqxmd.com/read/28513113/retina-and-nerve-fiber-layer-thickness-in-eyes-with-thyroid-associated-ophthalmopathy
#1
Sharon Blum Meirovitch, Igal Leibovitch, Anat Kesler, David Varssano, Amir Rosenblatt, Meira Neuderfer
BACKGROUND: Thyroid-associated ophthalmopathy (TAO) is an inflammatory disease that affects the thyroid gland and the eye orbit. Of patients with TAO, 3%-5% have severe sight-threatening disease due to optic neuropathy Optical coherence tomography (OCT), the non-invasive imaging technology that yields high-resolution cross-sectional images of the retina, provides qualitative and quantitative data on the retina. OBJECTIVES: To apply this technique to quantitatively assess retinal nerve fiber layer (RNFL) and macular ring thicknesses in healthy subjects and in patients with TAO to determine their relationship to the severity of the orbital disease...
May 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28492870/radiologic-parameters-of-orbital-bone-remodeling-in-thyroid-eye-disease
#2
Nicholas Y Q Tan, Yuan-Yuh Leong, Stephanie S Lang, Zin M Htoon, Stephanie M Young, Gangadhara Sundar
Purpose: To radiologically examine for the presence of bony remodeling of the orbit in thyroid eye disease (TED). Methods: Computed tomography (CT) scans of 248 orbits of 124 patients with TED and 185 orbits of 138 controls were retrospectively reviewed, and the following parameters measured: the angle of the inferomedial orbital strut (AIOS), the angle of the medial wall (AMW), and the diameters of the extraocular muscles. The association of TED with the AIOS or AMW was analyzed with linear regression models, and the correlations between the AMW or AIOS measurements with the extraocular muscle measurements were determined...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28491471/a-novel-three-dimensional-vector-analysis-of-axial-globe-position-in-thyroid-eye-disease
#3
Jie Guo, Jiang Qian, Yifei Yuan, Rui Zhang, Wenhu Huang
Purpose. To define a three-dimensional (3D) vector method to describe the axial globe position in thyroid eye disease (TED). Methods. CT data from 59 patients with TED were collected and 3D images were reconstructed. A reference coordinate system was established, and the coordinates of the corneal apex and the eyeball center were calculated to obtain the globe vector [Formula: see text]. The measurement reliability was evaluated. The parameters of [Formula: see text] were analyzed and compared with the results of two-dimensional (2D) CT measurement, Hertel exophthalmometry, and strabismus tests...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28485799/decreased-microrna-146a-in-cd4-t-cells-promote-ocular-inflammation-in-thyroid-associated-ophthalmopathy-by-targeting-numb
#4
Z-J Hu, J-F He, K-J Li, J Chen, X-R Xie
OBJECTIVE: The aim of the study was to explore the functional role of miR-146a in CD4+T cells of active thyroid-associated ophthalmopathy (TAO) patients and to identify the possible molecular mechanism for the modulation of miR-146a in TAO. PATIENTS AND METHODS: The experimental group collected six cases of peripheral venous blood of patients with active TAO. The healthy control group collected six cases of normal peripheral venous blood. All specimens excluded other eye diseases and autoimmune diseases, tumors, asthma, chronic inflammation, Human Immunodeficiency Virus (HIV), recent history of trauma, infection, and showed normal thyroid function...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28467880/teprotumumab-for-thyroid-associated-ophthalmopathy
#5
RANDOMIZED CONTROLLED TRIAL
Terry J Smith, George J Kahaly, Daniel G Ezra, James C Fleming, Roger A Dailey, Rosa A Tang, Gerald J Harris, Alessandro Antonelli, Mario Salvi, Robert A Goldberg, James W Gigantelli, Steven M Couch, Erin M Shriver, Brent R Hayek, Eric M Hink, Richard M Woodward, Kathleen Gabriel, Guido Magni, Raymond S Douglas
BACKGROUND: Thyroid-associated ophthalmopathy, a condition commonly associated with Graves' disease, remains inadequately treated. Current medical therapies, which primarily consist of glucocorticoids, have limited efficacy and present safety concerns. Inhibition of the insulin-like growth factor I receptor (IGF-IR) is a new therapeutic strategy to attenuate the underlying autoimmune pathogenesis of ophthalmopathy. METHODS: We conducted a multicenter, double-masked, randomized, placebo-controlled trial to determine the efficacy and safety of teprotumumab, a human monoclonal antibody inhibitor of IGF-IR, in patients with active, moderate-to-severe ophthalmopathy...
May 4, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28463526/long-term-surgical-outcomes-for-vertical-deviations-in-thyroid-eye-disease
#6
Lucy Barker, Kelly Mackenzie, Gill Gw Adams, Joanne Hancox
INTRODUCTION: Vertical deviations in thyroid eye disease (TED) can present a surgical challenge due to the difficulty and unpredictability of surgery and the high risk of postoperative drift towards overcorrection. This study reports the postoperative outcomes of patients who underwent adjustable vertical strabismus surgery with Vicryl sutures for thyroid eye disease. METHODS: We reviewed the records of patients seen for vertical TED strabismus surgery from January 2005 through December 2009...
May 2, 2017: Strabismus
https://www.readbyqxmd.com/read/28458939/isotretinoin-as-a-possible-environmental-trigger-to-autoimmunity-in-genetically-susceptible-patients
#7
Jocelyn Nugroho, Bahareh Schweiger
Introduction. Isotretinoin is commonly used to treat cystic acne. Definitive mechanisms of action for isotretinoin are not known though despite many side effects having been documented. Various case reports have noted autoimmune diseases succeeding isotretinoin treatment. Case Report. A 16-year-old female presents with symptoms of tremors, lack of focus, sleeplessness, emotional liability, bulging eyes, loose stools, heat intolerance, and missed menstrual periods. Symptoms manifested shortly after the patient finished a course of oral isotretinoin treatment for acne...
2017: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/28453366/patterns-of-visual-field-changes-in-thyroid-eye-disease
#8
Catherine J Choi, Susel Oropesa, Alison B Callahan, Lora R Glass, Livia Teo, Dean M Cestari, Michael Kazim, Suzanne K Freitag
This article provides a systematic description of visual field changes in thyroid eye disease-compressive optic neuropathy (TED-CON). A retrospective, non-comparative chart review of patients with TED-CON and documented Humphrey Visual Field 24-2 or 30-2 testing was conducted with IRB approval. Ninety-six visual fields in 68 patients were classified into 7 broad categories (superior, inferior, diffuse, temporal, nasal, central/paracentral, enlarged blind spot) and 17 mutually exclusive patterns from the Ocular Hypertension Treatment Study (OHTS) or "other...
April 28, 2017: Orbit
https://www.readbyqxmd.com/read/28450690/a-case-of-chronic-sarcoid-myopathy-with-basedow-s-disease-and-sjogren-s-syndrome-a-case-series-of-sarcoid-myopathy
#9
Takashi Isobe, Madoka Mori-Yoshimura, Yasushi Oya, Yuko Saito, Miho Murata, Ichizo Nishino, Yuji Takahashi
We report a 62-year-old woman with a history of Basedow's disease and Sjogren's syndrome who presented with slowly progressive limb muscle weakness over the course of ten years. On physical examination, she had dry eye and mouth, but was otherwise normal. Neurological examination revealed symmetrical proximal dominant muscle weakness. Polymyositis was suspected at initial diagnosis due to her clinical course, physical examination, and autoimmune disease. However, the final diagnosis based on a muscle biopsy was the chronic myopathic type of sarcoid myopathy...
April 27, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/28442380/incidence-and-risk-factors-of-symptomatic-dry-eye-disease-in-asian-malays-from-the-singapore-malay-eye-study
#10
Ryan E K Man, Anuradha R Veerappan, Shu-Pei Tan, Eva K Fenwick, Charumathi Sabanayagam, Jacqueline Chua, Yuan-Yuh Leong, Tien Yin Wong, Ecosse L Lamoureux, Ching-Yu Cheng, Louis Tong
PURPOSE: To evaluate the incidence of symptomatic dry eye disease (SDED) and associated risk factors in a well-characterized cohort of ethnic Malays in Singapore. METHODS: We included 1682 participants (mean age [SD]: 57 [10]years; 55.4% female) without SDED from the Singapore Malay Eye Study (SiMES), a population-based longitudinal study with baseline examination (SiMES-1) conducted between 2004 and 2006, and follow-up examination (SiMES-2) conducted between 2010 and 2013...
April 22, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28388348/geriatric-patients-are-predisposed-to-strabismus-following-thyroid-related-orbital-decompression-surgery-a-multivariate-analysis
#11
Chris Y Wu, Alon Kahana
Geriatric patients (age ≥ 65) are prone to complications after surgery and are at risk for severe thyroid eye disease (TED). In this study, we aim to identify preoperative demographic and TED patterns associated with geriatric patients who underwent decompression surgery, to examine the effect of age on postoperative strabismus rates, and to identify factors that may contribute to postoperative strabismus in the geriatric subgroup. We retrospectively reviewed patients who underwent thyroid-related orbital decompression surgery at the Kellogg Eye Center, University of Michigan, between 1999 and 2014...
April 2017: Orbit
https://www.readbyqxmd.com/read/28387769/-99-tc-m-octreotide-scintigraphy-and-serum-eye-muscle-antibodies-in-evaluation-of-active-thyroid-associated-ophthalmopathy
#12
B Sun, Z Zhang, C Dong, Y Zhang, C Yan, S Li
PurposeAs an autoimmune inflammatory disorder, active thyroid-associated ophthalmopathy (TAO) is managed optimally by immunosuppression. In this study, we aimed to evaluate octreotide scintigraphy and the level of serum extraocular muscle antibodies in TAO activity.Patients and methodsThis prospective study comprised 304 patients with active TAO (the clinical activity score; CAS≥3), 73 with inactive TAO (CAS<3), 128 with Graves' disease (GD) without ophthalmopathy, and 100 healthy subjects. Moderate-to-severe active TAO patients (CAS≥5) received intravenous injection of methylprednisolone; mild active patients (3≤CAS≤4) received periocular injection of triamcinolone acetonide...
May 2017: Eye
https://www.readbyqxmd.com/read/28369019/in-vivo-effects-of-retrobulbar-bimatoprost-injection-on-orbital-fat
#13
Kian Eftekhari, M Reza Vagefi, Vivian Lee, James Z Hui, Menglong Zhu, Kimberly Dine, Richard L Anderson, Brigitte Koeberlein, Reas Sulaimankutty, Kenneth S Shindler
PURPOSE: Recent publications have reported the adverse effects of prostaglandin analogues on the periocular tissues. These medications may cause periorbital lipodystrophy, enophthalmos, and deepening of the superior sulcus deformity. While these effects may have adverse consequences for some patients, the atrophy of the periorbital fat may have a useful role in diseases that lead to orbital and periorbital fat hypertrophy such as thyroid eye disease. In this pilot study, the authors investigated the effects of retrobulbar bimatoprost injection on the intraocular pressure and orbital fat in a rat animal model...
March 31, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28360983/association-between-serum-25-hydroxyvitamin-d-levels-and-dry-eye-in-korean-adults-a-study-based-on-korean-national-health-and-nutrition-examination-survey-2010-2011
#14
Min Ji Kim, Hye Rim Hwang, Yun-Jin Kim, Sang-Yeoup Lee, Jeong-Gyu Lee, Dong-Wook Jeong, Yun Hee Kim
BACKGROUND: Dry eye is a common disease. Many patients continue to experience residual symptoms despite optimal treatment. Thus, new treatment options are required. The purpose of this study was to evaluate the association between serum 25-hydroxyvitamin D [25(OH)D] levels and dry eye. METHODS: This study was performed using data from the fifth Korean National Health and Nutrition Examination Survey, which is a cross-sectional study of the Korean population that was conducted from 2010 to 2011...
March 2017: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/28343872/orbital-decompression-for-thyroid-eye-disease
#15
Daniel B Rootman
The literature regarding orbital decompression for thyroid eye disease is vast, spanning multiple specialty areas including neurosurgery, head and neck, maxillofacial and ophthalmic plastic surgery. Although techniques have advanced considerably over the more than 100 years during which this procedure has been performed, the four major approaches remain: transorbital, transcranial, transantral and transnasal. The explosion in literature related to orbital decompression has mostly involved minor technical variations on broader surgical themes...
March 23, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28328557/lateral-rectus-muscle-expands-more-than-medial-rectus-following-maximal-deep-balanced-orbital-decompression
#16
Adit Gupta, Alex Nobori, Yi Wang, Daniel Rootman, Robert Goldberg
PURPOSE: It has been reported that extraocular muscles can enlarge following orbital decompression in thyroid eye disease. In this article, the authors studied the changes in extraocular muscles size following maximal deep lateral and medial balanced decompression in a large sample of thyroid eye disease patients. METHODS: Imaging data were reviewed preoperatively and postoperatively. Radiologic proptosis was assessed. Maximal axial muscle width of the medial and lateral recti was measured...
March 21, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28319174/simultaneous-induction-of-graves-hyperthyroidism-and-graves-ophthalmopathy-by-tshr-genetic-immunization-in-balb-c-mice
#17
Nan Xia, Xiaozhen Ye, Xiaohao Hu, Shiyu Song, Hui Xu, Mengyuan Niu, Hongwei Wang, Jian Wang
BACKGROUND: Graves' disease is the most common form of autoimmune thyroid disorder, characterized by hyperthyroidism due to circulating autoantibodies. To address the pathological features and establish a therapeutic approach of this disease, an animal model carrying the phenotype of Graves' disease (GD) in concert with Graves' Ophthalmopathy (GO) will be very important. However, there are no ideal animal models that are currently available. The aim of the present study is to establish an animal model of GD and GO disease, and its pathological features were further characterized...
2017: PloS One
https://www.readbyqxmd.com/read/28303065/bilateral-lacrimal-caruncle-lesions
#18
Yuta Okumura, Yoshiko Takai, Shunsuke Yasuda, Hiroko Terasaki
A 65-year-old man was referred to our hospital for the treatment of a lesion on the medial lacrimal canthus of both eyes. He had a history of perinuclear anti-neutrophil cytoplasmic antibodies, i.e., pANCA-positive interstitial pneumonia. Orbital magnetic resonance imaging excluded space occupying lesions, and laboratory testing excluded thyroid-related diseases. The masses were excised, and histopathological examinations showed sebaceous gland hyperplasia and inflammatory changes around the gland. In addition, the specimen from the left eye showed a retention cyst possibly caused by an infection...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28296512/management-of-thyroid-eye-disease-in-the-united-kingdom-a-multi-centre-thyroid-eye-disease-audit
#19
F E Mellington, C M Dayan, A J Dickinson, J L Hickey, C J MacEwen, J McLaren, P Perros, G E Rose, J Uddin, B Vaidya, P Foley, J H Lazarus, A Mitchell, D G Ezra
This article aims to provide baseline data and highlight any major deficiencies in the current level of care provided for adult patients with thyroid eye disease (TED). We undertook a prospective, nonrandomized cross-sectional multicenter observational study. During a 3-month period June-August 2014, consecutive adult patients with TED who presented to nominated specialist eye clinics in the United Kingdom, completed a standardized questionnaire. Main outcome measures were: demographics, time from diagnosis to referral to tertiary centre, time from referral to review in specialist eye clinic, management of thyroid dysfunction, radioiodine and provision of steroid prophylaxis, smoking, and TED classification...
March 15, 2017: Orbit
https://www.readbyqxmd.com/read/28291193/-surgical-rehabilitation-of-patients-with-thyroid-eye-disease-systematic-approach
#20
S E Avetisov, Ya O Grusha, D S Ismailova, P A Kochetkov, S S Danilov, N Yu Sviridenko
AIM: to analyze the results of surgical treatment of patients with thyroid eye disease (TED), including the type of surgery, indications, and outcomes. MATERIAL AND METHODS: Hundred thirty-nine patients with TED (112 females, 27 males) aged 45.8±13.6 years. RESULTS: Bony orbital decompression was performed in 91 patients (128 orbits). After the surgery, visual acuity increased from 0.84±0.47 up to 0.94±0.32 (р<0.05), exophthalmos got reduced by the average of 3...
2017: Vestnik Oftalmologii
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