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Thyroid eye disease

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https://www.readbyqxmd.com/read/28606272/-progression-of-the-pathogenesis-of-thyroid-associated-ophthalmopathy
#1
L Wang, J M Ma
Thyroid associated ophthalmopathy (TAO) is a common complication of Graves' disease (GD). The clinical manifestations are mainly swelling and retracted eyelid, protopsis and limited eye movements, and optic neuropathy can be seen in severe cases. The mechanism of TAO is not yet clear. A large number of studies have found that the disorders of autoimmunity play an important role in TAO, while genetic factors, oxidative stress, and environmental factors such as smoking participate in it. Therefore, we consult a large number of studies and expound the pathogenesis from the aspects of genetic susceptibility, immune mechanism, oxidative stress, and the effects of smoking to provide referrences for clinical associated studies...
June 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28606262/-therapeutic-outcomes-and-influence-factors-of-maximal-orbital-decompression-in-the-treatment-of-severe-dysthyroid-optic-neuropathy
#2
Y Wang, Y Y Li, N Yang, R Ma, L H Xiao
Objective: To evaluate the effectiveness of maximal orbital decompression in treatment for severe dysthyroid optic neuropathy (DON) of thyroid associated ophthalmopathy (TAO) and predictive factors of this therapy. Methods: The group consisted of 21 patients (30 eyes) with DON. The diagnosis was based on the following criteria: Deterioration of best corrected visual acuity (VA≤0.1), enlargement of extraocular muscles and sign of apical crowding in CT imaging, loss of colour vision. EXCLUSION CRITERIA: VA of DON>0...
June 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28606260/-the-stepwise-establishment-of-standardized-treatment-for-the-thyroid-eye-disease
#3
J Qian
Thyroid associated ophthalmopathy is a complex autoimmune disease characterized by inflammation of the orbital tissue, hyaluronan deposition and tissue remodeling due to a skewed production of preadipocytic fibroblasts and increased adipogenesis in the late stage. Its progression is strongly related to the functional status of thyroid. So far, there is no consensus on staging, grading and treatment worldwide owning to the complexity of its clinical manifestations and therapies. However, it is of great importance to accurately judge its status and make individualized therapeutic regimen...
June 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28598870/molecularly-targeted-agents-in-oculoplastic-surgery
#4
Richard C Allen
PURPOSE OF REVIEW: Significant advances have been made in oncology and rheumatology with the introduction of molecularly targeted agents (MTAs). MTAs consist of monoclonal antibodies and small molecule inhibitors. The purpose of this manuscript is to review the recent applications of MTAs to orbital, lacrimal, and eyelid disease. RECENT FINDINGS: The use of monoclonal antibodies has been described in the treatment of orbital vascular lesions, lymphoma, and squamous cell carcinoma...
June 8, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28584858/a-longitudinal-population-study-of-the-impact-of-cataract-extraction-on-sleep-quality
#5
Yanjun Chen, David M Nondahl, Carla R Schubert, Dayna S Dalton, Adam J Paulsen, Barbara E K Klein, Ronald Klein, Karen J Cruickshanks
PURPOSE: To investigate the longitudinal effects of cataract extraction on sleep quality in two discrete population cohorts. METHODS: 301 participants who had senile cataract in both eyes at the baseline examination were selected from two large longitudinal epidemiologic studies of age-related eye disease, hearing, olfaction, and cognition. The participants were divided into two groups: one had cataract surgery (CS) in both eyes, and the other had no cataract surgery (NCS) in either eye by the follow up examination...
2017: Cogent Medicine
https://www.readbyqxmd.com/read/28576206/association-of-orbital-decompression-and-the-characteristics-of-subsequent-strabismus-surgery-in-thyroid-eye-disease
#6
Ofira Zloto, Guy Ben Simon, Ido Didi Fabian, Oded Sagiv, Ruth Huna-Baron, Itay Ben Zion, Tamara Wygnanski-Jaffe
OBJECTIVE: To examine the association of orbital decompression and the characteristics and outcome of subsequent strabismus surgery in patients with thyroid eye disease (TED). METHODS: Data on patients with TED who underwent orbital decompression at the Goldschleger Eye Institute, Sheba Medical Center, Israel, between January 1990 to December 2011 were extracted. The characteristics of decompression and strabismus surgeries were recorded. The outcomes and association of both surgical procedures were analyzed...
June 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28574497/stepping-into-the-virtual-unknown-feasibility-study-of-a-virtual-reality-based-test-of-ocular-misalignment
#7
N Nesaratnam, P Thomas, A Vivian
IntroductionDissociated tests of strabismus provide valuable information for diagnosis and monitoring of ocular misalignment in patients with normal retinal correspondence. However, they are vulnerable to operator error and rely on a fixed head position. Virtual reality headsets obviate the need for head fixation, while providing other clear theoretical advantages, including complete control over the illumination and targets presented for the patient's interaction.PurposeWe compared the performance of a virtual reality-based test of ocular misalignment to that of the traditional Lees screen, to establish the feasibility of using virtual reality technology in ophthalmic settings in the future...
June 2, 2017: Eye
https://www.readbyqxmd.com/read/28559720/magnitude-of-diabetes-and-hypertension-among-patients-with-dry-eye-syndrome-at-a-tertiary-hospital-of-riyadh-saudi-arabia-a-case-series
#8
Abdullah Omar Al Houssien, Rana Omar Al Houssien, Abdulaziz Al-Hawass
PURPOSE: To study the magnitude of chronic diseases among patients suffering from Dry Eye Syndrome (DES) and compare them with published findings in the literature. METHODS: Patients diagnosed in 2016 suffering from DES based on presenting symptoms and findings of ocular examination were included in this study. The demographic information included age and gender. Chronic diseases among them were identified through case records, assessment and ongoing medications...
April 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28553598/visual-evoked-potentials-in-overt-hypothyroid-patients-before-and-after-achievement-of-euthyroidism
#9
Aprajita, Geetanjali Sharma, Sameer Aggarwal
BACKGROUND: Visual evoked potential (VEP) measures the time taken for visual stimulus to travel from the eye to the occipital cortex. Hypothyroidism affects the central nervous system (CNS) through its role in gene expression, myelin production, axonal transportation, and neurotransmitters. Delay in the conduction of impulses results in abnormal VEP. OBJECTIVE: Correlate the electrophysiological findings of VEP in newly diagnosed treatment-naive hypothyroid patients before and after 3 months of treatment and to find the correlation with serum thyroid-stimulating hormone (TSH) levels...
May 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28513113/retina-and-nerve-fiber-layer-thickness-in-eyes-with-thyroid-associated-ophthalmopathy
#10
Sharon Blum Meirovitch, Igal Leibovitch, Anat Kesler, David Varssano, Amir Rosenblatt, Meira Neuderfer
BACKGROUND: Thyroid-associated ophthalmopathy (TAO) is an inflammatory disease that affects the thyroid gland and the eye orbit. Of patients with TAO, 3%-5% have severe sight-threatening disease due to optic neuropathy Optical coherence tomography (OCT), the non-invasive imaging technology that yields high-resolution cross-sectional images of the retina, provides qualitative and quantitative data on the retina. OBJECTIVES: To apply this technique to quantitatively assess retinal nerve fiber layer (RNFL) and macular ring thicknesses in healthy subjects and in patients with TAO to determine their relationship to the severity of the orbital disease...
May 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28492870/radiologic-parameters-of-orbital-bone-remodeling-in-thyroid-eye-disease
#11
Nicholas Y Q Tan, Yuan-Yuh Leong, Stephanie S Lang, Zin M Htoon, Stephanie M Young, Gangadhara Sundar
Purpose: To radiologically examine for the presence of bony remodeling of the orbit in thyroid eye disease (TED). Methods: Computed tomography (CT) scans of 248 orbits of 124 patients with TED and 185 orbits of 138 controls were retrospectively reviewed, and the following parameters measured: the angle of the inferomedial orbital strut (AIOS), the angle of the medial wall (AMW), and the diameters of the extraocular muscles. The association of TED with the AIOS or AMW was analyzed with linear regression models, and the correlations between the AMW or AIOS measurements with the extraocular muscle measurements were determined...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28491471/a-novel-three-dimensional-vector-analysis-of-axial-globe-position-in-thyroid-eye-disease
#12
Jie Guo, Jiang Qian, Yifei Yuan, Rui Zhang, Wenhu Huang
Purpose. To define a three-dimensional (3D) vector method to describe the axial globe position in thyroid eye disease (TED). Methods. CT data from 59 patients with TED were collected and 3D images were reconstructed. A reference coordinate system was established, and the coordinates of the corneal apex and the eyeball center were calculated to obtain the globe vector [Formula: see text]. The measurement reliability was evaluated. The parameters of [Formula: see text] were analyzed and compared with the results of two-dimensional (2D) CT measurement, Hertel exophthalmometry, and strabismus tests...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28485799/decreased-microrna-146a-in-cd4-t-cells-promote-ocular-inflammation-in-thyroid-associated-ophthalmopathy-by-targeting-numb
#13
Z-J Hu, J-F He, K-J Li, J Chen, X-R Xie
OBJECTIVE: The aim of the study was to explore the functional role of miR-146a in CD4+T cells of active thyroid-associated ophthalmopathy (TAO) patients and to identify the possible molecular mechanism for the modulation of miR-146a in TAO. PATIENTS AND METHODS: The experimental group collected six cases of peripheral venous blood of patients with active TAO. The healthy control group collected six cases of normal peripheral venous blood. All specimens excluded other eye diseases and autoimmune diseases, tumors, asthma, chronic inflammation, Human Immunodeficiency Virus (HIV), recent history of trauma, infection, and showed normal thyroid function...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28467880/teprotumumab-for-thyroid-associated-ophthalmopathy
#14
RANDOMIZED CONTROLLED TRIAL
Terry J Smith, George J Kahaly, Daniel G Ezra, James C Fleming, Roger A Dailey, Rosa A Tang, Gerald J Harris, Alessandro Antonelli, Mario Salvi, Robert A Goldberg, James W Gigantelli, Steven M Couch, Erin M Shriver, Brent R Hayek, Eric M Hink, Richard M Woodward, Kathleen Gabriel, Guido Magni, Raymond S Douglas
BACKGROUND: Thyroid-associated ophthalmopathy, a condition commonly associated with Graves' disease, remains inadequately treated. Current medical therapies, which primarily consist of glucocorticoids, have limited efficacy and present safety concerns. Inhibition of the insulin-like growth factor I receptor (IGF-IR) is a new therapeutic strategy to attenuate the underlying autoimmune pathogenesis of ophthalmopathy. METHODS: We conducted a multicenter, double-masked, randomized, placebo-controlled trial to determine the efficacy and safety of teprotumumab, a human monoclonal antibody inhibitor of IGF-IR, in patients with active, moderate-to-severe ophthalmopathy...
May 4, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28463526/long-term-surgical-outcomes-for-vertical-deviations-in-thyroid-eye-disease
#15
Lucy Barker, Kelly Mackenzie, Gill Gw Adams, Joanne Hancox
INTRODUCTION: Vertical deviations in thyroid eye disease (TED) can present a surgical challenge due to the difficulty and unpredictability of surgery and the high risk of postoperative drift towards overcorrection. This study reports the postoperative outcomes of patients who underwent adjustable vertical strabismus surgery with Vicryl sutures for thyroid eye disease. METHODS: We reviewed the records of patients seen for vertical TED strabismus surgery from January 2005 through December 2009...
May 2, 2017: Strabismus
https://www.readbyqxmd.com/read/28458939/isotretinoin-as-a-possible-environmental-trigger-to-autoimmunity-in-genetically-susceptible-patients
#16
Jocelyn Nugroho, Bahareh Schweiger
Introduction. Isotretinoin is commonly used to treat cystic acne. Definitive mechanisms of action for isotretinoin are not known though despite many side effects having been documented. Various case reports have noted autoimmune diseases succeeding isotretinoin treatment. Case Report. A 16-year-old female presents with symptoms of tremors, lack of focus, sleeplessness, emotional liability, bulging eyes, loose stools, heat intolerance, and missed menstrual periods. Symptoms manifested shortly after the patient finished a course of oral isotretinoin treatment for acne...
2017: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/28453366/patterns-of-visual-field-changes-in-thyroid-eye-disease
#17
Catherine J Choi, Susel Oropesa, Alison B Callahan, Lora R Glass, Livia Teo, Dean M Cestari, Michael Kazim, Suzanne K Freitag
This article provides a systematic description of visual field changes in thyroid eye disease-compressive optic neuropathy (TED-CON). A retrospective, non-comparative chart review of patients with TED-CON and documented Humphrey Visual Field 24-2 or 30-2 testing was conducted with IRB approval. Ninety-six visual fields in 68 patients were classified into 7 broad categories (superior, inferior, diffuse, temporal, nasal, central/paracentral, enlarged blind spot) and 17 mutually exclusive patterns from the Ocular Hypertension Treatment Study (OHTS) or "other...
April 28, 2017: Orbit
https://www.readbyqxmd.com/read/28450690/a-case-of-chronic-sarcoid-myopathy-with-basedow-s-disease-and-sjogren-s-syndrome-a-case-series-of-sarcoid-myopathy
#18
Takashi Isobe, Madoka Mori-Yoshimura, Yasushi Oya, Yuko Saito, Miho Murata, Ichizo Nishino, Yuji Takahashi
We report a 62-year-old woman with a history of Basedow's disease and Sjogren's syndrome who presented with slowly progressive limb muscle weakness over the course of ten years. On physical examination, she had dry eye and mouth, but was otherwise normal. Neurological examination revealed symmetrical proximal dominant muscle weakness. Polymyositis was suspected at initial diagnosis due to her clinical course, physical examination, and autoimmune disease. However, the final diagnosis based on a muscle biopsy was the chronic myopathic type of sarcoid myopathy...
April 27, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/28442380/incidence-and-risk-factors-of-symptomatic-dry-eye-disease-in-asian-malays-from-the-singapore-malay-eye-study
#19
Ryan E K Man, Anuradha R Veerappan, Shu-Pei Tan, Eva K Fenwick, Charumathi Sabanayagam, Jacqueline Chua, Yuan-Yuh Leong, Tien Yin Wong, Ecosse L Lamoureux, Ching-Yu Cheng, Louis Tong
PURPOSE: To evaluate the incidence of symptomatic dry eye disease (SDED) and associated risk factors in a well-characterized cohort of ethnic Malays in Singapore. METHODS: We included 1682 participants (mean age [SD]: 57 [10]years; 55.4% female) without SDED from the Singapore Malay Eye Study (SiMES), a population-based longitudinal study with baseline examination (SiMES-1) conducted between 2004 and 2006, and follow-up examination (SiMES-2) conducted between 2010 and 2013...
April 22, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28388348/geriatric-patients-are-predisposed-to-strabismus-following-thyroid-related-orbital-decompression-surgery-a-multivariate-analysis
#20
Chris Y Wu, Alon Kahana
Geriatric patients (age ≥ 65) are prone to complications after surgery and are at risk for severe thyroid eye disease (TED). In this study, we aim to identify preoperative demographic and TED patterns associated with geriatric patients who underwent decompression surgery, to examine the effect of age on postoperative strabismus rates, and to identify factors that may contribute to postoperative strabismus in the geriatric subgroup. We retrospectively reviewed patients who underwent thyroid-related orbital decompression surgery at the Kellogg Eye Center, University of Michigan, between 1999 and 2014...
April 2017: Orbit
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