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https://www.readbyqxmd.com/read/28092416/persistence-of-antibody-to-hepatitis-a-virus-20-years-after-receipt-of-hepatitis-a-vaccine-in-alaska
#1
Ian D Plumb, Lisa R Bulkow, Michael G Bruce, Thomas W Hennessy, Julie Morris, Karen Rudolph, Philip Spradling, Mary Snowball, Brian J McMahon
Hepatitis A vaccine is recommended for children ≥1 year old to prevent hepatitis A virus (HAV) infection. However the duration of vaccine-induced immunity is unknown. We evaluated a cohort of Alaska Native persons 20 years after HAV vaccination. Children aged 3-6 years had been previously randomized to receive 3 doses of HAV vaccine (360 ELISA units/dose) at: A) 0,1,2 months; B) 0,1,6 months; and C) 0,1,12 months. We measured anti-HAV antibody concentrations every 2-3 years; described geometric mean concentrations (GMC) and the proportion with protective antibody (≥20 mIU mL-1) over time; and modelled change in GMC using fractional polynomial regression...
January 16, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28087501/employers-should-not-add-management-objectives-to-revalidation-process-gmc-says
#2
Abi Rimmer
No abstract text is available yet for this article.
January 13, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28073776/managers-must-respond-to-doctors-patient-safety-concerns-gmc-says
#3
Tom Moberly
No abstract text is available yet for this article.
January 10, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28063006/therapeutic-value-of-nerve-growth-factor-in-promoting-neural-stem-cell-survival-and-differentiation-and-protecting-against-neuronal-hearing-loss
#4
Zhao Han, Cong-Pin Wang, Ning Cong, Yu-Yan Gu, Rui Ma, Fang-Lu Chi
Nerve growth factor (NGF) is a neurotrophic factor that modulates survival and differentiation of neural stem cells (NSCs). We investigated the function of NGF in promoting growth and neuronal differentiation of NSCs isolated from mouse cochlear tissue, as well as its protective properties against gentamicin (GMC) ototoxicity. NSCs were isolated from the cochlea of mice and cultured in vitro. Effect of NGF on survival, neurosphere formation, and differentiation of the NSCs, as well as neurite outgrowth and neural excitability in the subsequent in vitro neuronal network, was examined...
January 7, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28060048/a-randomized-controlled-trial-to-evaluate-a-potential-hepatitis-b-booster-vaccination-strategy-using-combined-hepatitis-a-and-b-vaccine
#5
Fangjun Li, Yuansheng Hu, Youming Zhou, Lixin Chen, Wei Xia, Yufei Song, Zhengliang Tan, Lidong Gao, Zhong Yang, Gang Zeng, Xing Han
BACKGROUND: Booster doses could play a major role in those no responders or low responders to primary hepatitis B vaccine. Planed time point for hepatitis A vaccination in China provides a good opportunity to carry out hepatitis B booster dose by using combined hepatitis A and B vaccine. METHOD: A randomized, double blinded clinical trial was conducted to compare the immunogenicity and safety of toddlers 18-24 months of age receiving three different vaccination regimens: either two doses of inactivated hepatitis A vaccine (group 1), or one dose inactivated hepatitis A vaccine plus one dose combined hepatitis A and B vaccine (group 2), or two doses of combined hepatitis A and B vaccine (group 3) respectively...
January 3, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28059055/gluteal-muscle-contracture-diagnosis-and-management-options
#6
Saroj Rai, Chunqing Meng, Xiaohong Wang, Nabin Chaudhary, Shengyang Jin, Shuhua Yang, Hong Wang
Gluteal muscle contracture (GMC), a debilitating disease, exists all over the globe but it is much more prevalent in China. Patients typically present with abduction and external rotation of the hip and are unable to bring both the knees together while squatting. Multiple etiologies have been postulated, the commonest being repeated intramuscular injection into the buttocks. The disease is diagnosed primarily by clinical features but radiological features are necessary for the exclusion of other pathological conditions...
2017: SICOT-J
https://www.readbyqxmd.com/read/28052572/an-undergraduate-otolaryngology-curriculum-comparison-in-the-united-kingdom-using-a-curriculum-evaluation-framework
#7
R A Steven, G J Mires, S K W Lloyd, S McAleer
OBJECTIVE: 1.To compare undergraduate Otolaryngology curricula in the United Kingdom. 2.To develop a tool which would allow undergraduate specialty curricula to be compared. DESIGN: Development of a Curriculum Evaluation Framework and survey. SETTING: UK medical schools. PARTICIPANTS: Otolaryngology curricula were requested from all 32 UK medical schools who award a primary medical qualification. 19 curricula were received and examined...
January 4, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28048688/su-f-t-155-validation-of-a-commercial-monte-carlo-dose-calculation-algorithm-for-proton-therapy
#8
J Saini, S St James, E Traneus, T Wong, R Stewart, C Bloch
PURPOSE: Compare proton pencil beam scanning dose measurements to GATE/GEANT4 (GMC) and RayStation™ Monte Carlo (RMC) simulations. METHODS: Proton pencil beam models of the IBA gantry at the Seattle Proton Therapy Center were developed in the GMC code system and a research build of the RMC. For RMC, a preliminary beam model that does not account for upstream halo was used. Depth dose and lateral profiles are compared for the RMC, GMC and a RayStation™ pencil beam dose (RPB) model for three spread out Bragg peaks (SOBPs) in homogenous water phantom...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045585/immunogenicity-and-safety-of-purified-vero-cell-rabies-vaccine-pvrv-under-zagreb-2-1-1-or-5-dose-essen-regimen-in-chinese-adults-aged-50-and-above
#9
Jing Wang, FengJi Luo, ZiJian Feng, Li Li, YunHua Bai, Xing Ai, JianXin Ma, Zheng Zhang, NianMin Shi
BACKGROUND: Two kinds of regimens (2-1-1 and 1-1-1-1-1) can be selected after Zagreb regimen(2-1-1)of PVRV was officially approved in Beijing in January 2015. Up to now, the subjects for most studies about the comparison between Zagreb and Essen regimen are under 50 years old, rarely at and above. Aging of the immune system may result in decreasing efficacy of vaccination, especially for adults aged above 65-70 years. This study compared the safety and immunogenicity of the Zagreb and Essen regimen in Chinese adults aged 50 and above with the goal to provide a supplemental data for this age group...
January 3, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28040688/prevalence-of-pertussis-antibodies-in-maternal-blood-cord-serum-and-infants-from-mothers-with-and-those-without-tdap-booster-vaccination-during-pregnancy-in-argentina
#10
Aurelia A Fallo, Silvina E Neyro, Gabriela V Manonelles, Claudia Lara, Daniela Hozbor, Jonathan Zintgraff, Silvina Mazzeo, Héctor E Davison, Susana González, Estella Zapulla, Oscar Canle, Miguel Huespe, Marcelo Galas, Eduardo L López
BACKGROUND: Morbidity and mortality rates for pertussis in infants are high because disease often occurs before the onset of routine immunization or in those who do not complete a primary immunization series. Pertussis immunization is recommended during pregnancy to achieve antibody levels sufficient to protect young infants. To our knowledge, no previous reports of maternal pertussis immunization results in Latin America exist in the literature. METHODS: This study compared pertussis antibody levels in newborns from mothers who received or did not receive a tetanus-diphtheria-acellular pertussis vaccination (TdapV) during pregnancy...
December 30, 2016: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28039298/sublytic-c5b-9-induces-glomerular-mesangial-cell-apoptosis-through-the-cascade-pathway-of-mekk2-p38-mapk-irf-1-tradd-caspase-8-in-rat-thy-1-nephritis
#11
Ganqian Zhu, Wen Qiu, Yongting Li, Chenhui Zhao, Fengxia He, Mengya Zhou, Lulu Wang, Dan Zhao, Yanlai Lu, Jing Zhang, Yu Liu, Tianyi Yu, Yingwei Wang
The apoptosis of glomerular mesangial cells (GMCs) in the early phase of rat Thy-1 nephritis (Thy-1N), a model of human mesangioproliferative glomerulonephritis (MsPGN), is primarily triggered by sublytic C5b-9. However, the mechanism of GMC apoptosis induced by sublytic C5b-9 remains unclear. In this study, we demonstrate that expressions of TNFR1-associated death domain-containing protein (TRADD) and IFN regulatory factor-1 (IRF-1) were simultaneously upregulated in the renal tissue of Thy-1N rats (in vivo) and in GMCs under sublytic C5b-9 stimulation (in vitro)...
December 30, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28039292/to-condition-or-not-condition-analysing-change-in-longitudinal-randomised-controlled-trials
#12
Cynthia J Coffman, David Edelman, Robert F Woolson
OBJECTIVE: The statistical analysis for a 2-arm randomised controlled trial (RCT) with a baseline outcome followed by a few assessments at fixed follow-up times typically invokes traditional analytic methods (eg, analysis of covariance (ANCOVA), longitudinal data analysis (LDA)). 'Constrained' longitudinal data analysis (cLDA) is a well-established unconditional technique that constrains means of baseline to be equal between arms. We use an analysis of fasting lipid profiles from the Group Medical Clinics (GMC) longitudinal RCT on patients with diabetes to illustrate applications of ANCOVA, LDA and cLDA to demonstrate theoretical concepts of these methods including the impact of missing data...
December 30, 2016: BMJ Open
https://www.readbyqxmd.com/read/28026149/arctigenin-protects-against-neuronal-hearing-loss-by-promoting-neural-stem-cell-survival-and-differentiation
#13
Xinghua Huang, Mo Chen, Yan Ding, Qin Wang
Neuronal hearing loss has become a prevalent health problem. This study focused on the function of arctigenin (ARC) in promoting survival and neuronal differentiation of mouse cochlear neural stem cells (NSCs), and its protection against gentamicin (GMC) induced neuronal hearing loss. Mouse cochlea was utilized to isolate NSCs, which were subsequently cultured in vitro. The effects of ARC on NSC survival, neurosphere formation, differentiation of NSCs, neurite outgrowth and neural excitability in neuronal network in vitro were examined...
December 27, 2016: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/28025229/malpractice-criminality-and-medical-regulation-reforming-the-role-of-the-gmc-in-fitness-to-practise-panels
#14
John Martyn Chamberlain
A recent Law Commission Review emphasised that medical fitness to practise panels (also called medical practitioners tribunals) are an important legal mechanism for ensuring that public trust in medical regulation is maintained when a complaint is made against a doctor. This article examines trends over time in panel outcomes to identify their effectiveness in ensuring public protection. Although a rise in complaints, and a change from the criminal to civil standard of proof, has not led to more doctors being struck off the medical register, increasingly action is being taken to provide advice, issue warnings, and agree rehabilitative forms of action with doctors...
December 26, 2016: Medical Law Review
https://www.readbyqxmd.com/read/28024571/ocular-biocompatibility-of-gelatin-microcarriers-functionalized-with-oxidized-hyaluronic-acid
#15
Jui-Yang Lai, David Hui-Kang Ma
Given that the presence of aldehyde groups on the oxidized sugar residues may pose toxicity concerns, it is necessary to examine the safety of gelatin microcarriers (GMC) functionalized with oxidized hyaluronic acid (oHA) for potential ophthalmic applications. In this study, the ocular biocompatibility of biopolymer microcarriers was investigated in vitro using primary rabbit corneal cell cultures and in vivo using the anterior chamber of the rabbit eye model. Our results showed that different types of corneal cells including epithelial, stromal, and endothelial cells remain viable and actively proliferate following 2 and 4days of exposure to test materials...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28011916/immune-responses-after-two-versus-three-doses-of-hpv-vaccination-up-to-4%C3%A2-years-post-vaccination-an-observational-study-among-dutch-routinely-vaccinated-girls-hpv2d
#16
Robine Donken, Tessa M Schurink-van 't Klooster, Rutger M Schepp, Fiona R M van der Klis, Mirjam J Knol, Chris J L M Meijer, Hester E de Melker
BACKGROUND: In 2014 the Netherlands switched from three- to two-doses for routine vaccination with the prophylactic bivalent human papillomavirus (HPV)-vaccine. This study explored whether antibody responses are non-inferior after two- compared to three-doses in girls. METHODS: Girls vaccinated at twelve years of age with two-(0,6 months) or three-doses (0,1,6 months) of the bivalent HPV vaccine were identified in the vaccination registration system. Type-specific antibody concentrations and avidity against HPV16/18/31/33/45/52/58 were assessed...
December 23, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28010246/safety-and-immunogenicity-of-a-recombinant-staphylococcus-aureus-%C3%AE-toxoid-and-a-recombinant-panton-valentine-leukocidin-subunit-in-healthy-adults
#17
Michael L Landrum, Tahaniyat Lalani, Minoo Niknian, Jason D Maguire, Duane R Hospenthal, Ali Fattom, Kimberly Taylor, Jamie Fraser, Kenneth Wilkins, Michael W Ellis, Paul D Kessler, Rafaat E F Fahim, David R Tribble
We conducted a randomized, double-blind, placebo-controlled dose-escalation study in healthy adults to evaluate the safety and immunogenicity of recombinant Staphylococcus aureus candidate vaccine antigens, recombinant α-toxoid (rAT) and a sub-unit of Panton-Valentine leukocidin (rLukS-PV). 176 subjects were enrolled and randomized within 1 of 11 treatment cohorts: monovalent rAT or rLukS-PV dosages of 10, 25, 50, and 100 μg; bivalent rAT:rLukS dosages of 10:10, 25:25, and 50:50 μg; and alum or saline placebo...
December 23, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27995309/characterization-of-three-pyranose-dehydrogenase-isoforms-from-the-litter-decomposing-basidiomycete-leucoagaricus-meleagris-syn-agaricus-meleagris
#18
Michael M H Graf, Sandra Weber, Daniel Kracher, Roman Kittl, Christoph Sygmund, Roland Ludwig, Clemens Peterbauer, Dietmar Haltrich
Multigenicity is commonly found in fungal enzyme systems, with the purpose of functional compensation upon deficiency of one of its members or leading to enzyme isoforms with new functionalities through gene diversification. Three genes of the flavin-dependent glucose-methanol-choline (GMC) oxidoreductase pyranose dehydrogenase (AmPDH) were previously identified in the litter-degrading fungus Agaricus (Leucoagaricus) meleagris, of which only AmPDH1 was successfully expressed and characterized. The aim of this work was to study the biophysical and biochemical properties of AmPDH2 and AmPDH3 and compare them with those of AmPDH1...
December 19, 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27986508/screening-breast-mri-outcomes-in-routine-clinical-practice-comparison-to-bi-rads-benchmarks
#19
Roberta M Strigel, Jennifer Rollenhagen, Elizabeth S Burnside, Mai Elezaby, Amy M Fowler, Frederick Kelcz, Lonie Salkowski, Wendy B DeMartini
RATIONALE AND OBJECTIVES: The BI-RADS Atlas 5th Edition includes screening breast magnetic resonance imaging (MRI) outcome benchmarks. However, the metrics are from expert practices and clinical trials of women with hereditary breast cancer predispositions, and it is unknown if they are appropriate for routine practice. We evaluated screening breast MRI audit outcomes in routine practice across a spectrum of elevated risk patients. MATERIALS AND METHODS: This Institutional Review Board-approved, Health Insurance Portability and Accountability Act-compliant retrospective study included all consecutive screening breast MRI examinations from July 1, 2010 to June 30, 2013...
December 13, 2016: Academic Radiology
https://www.readbyqxmd.com/read/27927993/suppression-of-extracellular-invertase-inhibitor-gene-expression-improves-seed-weight-in-soybean-glycine-max
#20
Xiaofei Tang, Tao Su, Mei Han, Lai Wei, Weiwei Wang, Zhiyuan Yu, Yongguo Xue, Hongbin Wei, Yejie Du, Steffen Greiner, Thomas Rausch, Lijun Liu
Cell wall invertase (CWI) and vacuolar invertase (VI) play multiple functions in plant growth. As well as depending on transcriptional and post-transcriptional regulation, there is growing evidence that CWI and VI are also subject to post-translational control by small inhibitory proteins. Despite the significance of this, genes encoding inhibitors, their molecular and biochemical properties, and their potential roles in regulating seed production have not been well documented in soybean (Glycine max). In this study, two invertase inhibitor isoforms, GmCIF1 and GmC/VIF2, were characterized to possess inhibitory activities in vitro via heterologous expression...
December 7, 2016: Journal of Experimental Botany
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