keyword
MENU ▼
Read by QxMD icon Read
search

GMC

keyword
https://www.readbyqxmd.com/read/27914009/serum-response-factor-srf-ablation-interferes-with-acute-stress-associated-immediate-and-long-term-coping-mechanisms
#1
Annemarie Zimprich, Gabi Mroz, Christopher Meyer Zu Reckendorf, Sofia Anastasiadou, Philip Förstner, Lillian Garrett, Sabine M Hölter, Lore Becker, Jan Rozman, Cornelia Prehn, Birgit Rathkolb, Kristin Moreth, Wolfgang Wurst, Thomas Klopstock, Martin Klingenspor, Jerzy Adamski, Eckhard Wolf, Raffi Bekeredjian, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis, Bernd Knöll
Stress experience modulates behavior, metabolism, and energy expenditure of organisms. One molecular hallmark of an acute stress response is a rapid induction of immediate early genes (IEGs) such as c-Fos and Egr family members. IEG transcription in neurons is mediated by the neuronal activity-driven gene regulator serum response factor (SRF). We show a first role of SRF in immediate and long-lasting acute restraint stress (AS) responses. For this, we employed a standardized mouse phenotyping protocol at the German Mouse Clinic (GMC) including behavioral, metabolic, and cardiologic tests as well as gene expression profiling to analyze the consequences of forebrain-specific SRF deletion in mice exposed to AS...
December 2, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27908901/workloads-threaten-to-undermine-doctors-training-gmc-finds
#2
Abi Rimmer
No abstract text is available yet for this article.
December 1, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27900442/arthroscopic-revision-release-of-gluteal-muscle-contracture-after-failed-primary-open-surgery
#3
Xintao Zhang, Xiaocheng Jiang, Feilin He, Zuru Liang, Tian You, Dadi Jin, Wentao Zhang
PURPOSE: The treatment of gluteal muscle contracture (GMC) after failed primary open release surgery has rarely been reported in the literature. GMC is a troublesome health problem in some developing countries, and it can result in the limitation of patients' hip function, leading to the development of inferiority complexes. The aim of this study is to evaluate the effect of arthroscopic revision surgery after failed primary open release on patients with GMC. METHODS: A total of 278 hips of 140 patients who underwent arthroscopic revision procedures after failed primary open surgeries were gathered from the department files...
November 29, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27894717/hepatitis-b-vaccine-alone-may-be-enough-for-preventing-hepatitis-b-virus-transmission-in-neonates-of-hbsag-hbeag-mothers
#4
Ying Lu, Xiao-Feng Liang, Fu-Zhen Wang, Ling Yan, Rong-Cheng Li, Yan-Ping Li, Feng-Cai Zhu, Xiang-Jun Zhai, Jie Li, Hui Zhuang
BACKGROUND AND AIM: To prospectively evaluate the efficacy of vaccine alone compared with vaccine plus HBIG for preventing HBV transmission in neonates of HBsAg (+)/HBeAg (-) mothers. METHODS: Combined immunization is currently recommended for neonates of HBsAg (+) mothers in China. As a result, a randomized design is infeasible due to ethical reasons. In practice, Guangxi Zhuang Autonomous Region and Jiangsu Province implement vaccine alone and vaccine plus HBIG strategies for neonates born to HBsAg (+)/HBeAg (-) mothers, respectively...
November 25, 2016: Vaccine
https://www.readbyqxmd.com/read/27891433/the-clinical-presentation-and-outcome-of-the-institutionalized-wandering-mentally-ill-in-india
#5
Gaurav Singh, Nilima Shah, Ritambhara Mehta
INTRODUCTION: There are estimated 400,000 wandering mentally ill persons in India, found in poor physical state wandering on streets and railway stations; mainly treated either by government run Hospitals for Mental Health (HMH) or Psychiatry units of a Government Medical College (GMC). They require psychosocial rehabilitation along with treatment. AIM: To study the presentation, clinical profile and rehabilitative outcome of wandering mentally ill admitted in government psychiatric care facilities...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27884146/demographic-and-clinical-profiles-of-plasmodium-falciparum-and-plasmodium-vivax-patients-at-a-tertiary-care-centre-in-southwestern-india
#6
Laura Chery, Jennifer N Maki, Anjali Mascarenhas, Jayashri T Walke, Pooja Gawas, Anvily Almeida, Mezia Fernandes, Marina Vaz, Rakesh Ramanan, Diksha Shirodkar, Maria Bernabeu, Suresh Kumar Manoharan, Ligia Pereira, Rashmi Dash, Ambika Sharma, Riaz Basha Shaik, Rimi Chakrabarti, Prasad Babar, John White, Devaraja G Mudeppa, Shiva Kumar, Wenyun Zuo, Kristen M Skillman, Usheer Kanjee, Caeul Lim, Kathryn Shaw-Saliba, Ashwani Kumar, Neena Valecha, V N Jindal, Anar Khandeparkar, Pradeep Naik, Sunanda Amonkar, Manoj T Duraisingh, Shripad Tuljapurkar, Joseph D Smith, Nagesh Dubhashi, Roque G W Pinto, Maria Silveria, Edwin Gomes, Pradipsinh K Rathod
BACKGROUND: Malaria remains an important cause of morbidity and mortality in India. Though many comprehensive studies have been carried out in Africa and Southeast Asia to characterize and examine determinants of Plasmodium falciparum and Plasmodium vivax malaria pathogenesis, fewer have been conducted in India. METHODS: A prospective study of malaria-positive individuals was conducted at Goa Medical College and Hospital (GMC) from 2012 to 2015 to identify demographic, diagnostic and clinical indicators associated with P...
November 25, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27879555/safety-and-immunogenicity-of-dtap5-ipv-compared-with-dtap5-plus-ipv-as-the-fifth-dose-in-children-4-to-6-years-of-age
#7
Michael J Smith, Emilia Jordanov, Xiaohua Sheng, Peter H Tsang
BACKGROUND: Immunogenicity and safety of stand-alone diphtheria, tetanus toxoid, 5-component acellular pertussis vaccine adsorbed, inactivated poliovirus (IPV) combination vaccine (DTaP5-IPV) was compared with separate DTaP5 plus IPV vaccines as fifth dose in children 4-6 years of age. METHODS: In this phase III, controlled, multicenter, randomized, open-label study participants were randomized to DTaP5-IPV plus measles/mumps/rubella (MMR) and varicella virus (VZV) vaccines (Group 1; N=324), DTaP5+IPV with MMR and VZV (Group 2; N=327), DTaP5-IPV with/without MMR/VZV (Group 3; N=2419), or DTaP5+IPV with/without MMR/VZV (Group 4; N=302)...
November 22, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27874311/long-term-persistence-in-protection-and-response-to-a-hepatitis-b-vaccine-booster-among-adolescents-immunized-in-infancy-in-the-western-region-of-china
#8
Zhen-Zi Wang, Yu-Hua Gao, Wei Lu, Cun-Duo Jin, Ying Zeng, Ling Yan, Feng Ding, Tong Li, Xue-En Liu, Hui Zhuang
OBJECTIVES: To evaluate the persistence of protection from hepatitis B (HB) vaccination among adolescents immunized with a primary series of HB vaccine as infants, and the immune response to booster doses. METHODS: Healthy adolescents aged 15-17 years vaccinated with HB vaccine only at birth were enrolled. Baseline serum hepatitis B surface antigen (HBsAg), antibody against hepatitis B surface antigen (anti-HBs) and antibody against hepatitis B core antigen (anti-HBc) were detected by Enzyme-Linked Immunosorbent Assay (ELISA) and anti-HBs level was measured using Chemiluminescent Microparticle Immunoassay (CMIA)...
November 22, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27857051/elevation-of-the-acth-cortisol-ratio-in-female-opioid-dependent-patients-a-biomarker-of-aging-and-correlate-of-metabolic-and-immune-activation
#9
(no author information available yet)
BACKGROUND: Whilst the hypothalamic-pituitary-adrenal (HPA) Axis is a major stress axis, and is necessarily perturbed in opioid dependency, and stress is a major contributor to aging mechanisms, the HPA axis has not been studied in opioid dependency in an age-dependent manner. OBJECTIVE: Hypothesis - Differences in age dependent levels of HPA components. DESIGN: Cross-sectional comparison of general medical and opioid dependent patients (ODP, GMP)...
September 18, 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/27848436/who-speaks-for-nurses
#10
David Harding-Price
The General Medical Council (GMC) has publicly stated doctors are under growing pressure. I wonder why the Nursing and Midwifery Council (NMC) has not spoken up for nurses in the same vein?
November 9, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27846058/lot-to-lot-consistency-safety-tolerability-and-immunogenicity-of-an-investigational-hexavalent-vaccine-in-us-infants
#11
Stanley L Block, Nicola P Klein, Kwabena Sarpong, Stephen Russell, John Fling, Maria Petrecz, Sheryl Flores, Jin Xu, Guanghan Liu, Jon E Stek, Ginamarie Foglia, Andrew W Lee
BACKGROUND: This multicenter Phase III study (NCT01340937) evaluated the consistency of immune responses to 3 separate lots of DTaP5-IPV-Hib-HepB, an investigational hexavalent vaccine (HV). METHODS: Healthy infants were randomized (2:2:2:1) to receive HV or Pentacel (Control). Groups 1, 2, and 3 received HV at 2, 4, and 6 months, and Control at 15 months. Group 4 received Control at 2, 4, 6, and 15 months, plus Recombivax HB (HepB) at 2 and 6 months. Concomitant Prevnar 13 (PCV13) was given to all groups at 2, 4, 6, and 15 months; pentavalent rotavirus vaccine (RV5) was given to all groups at 2, 4, and 6 months...
November 11, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27821388/who-refers-29m-oxford-research-project-to-gmc-for-misconduct
#12
Nigel Hawkes
No abstract text is available yet for this article.
November 7, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27819116/safety-and-immunogenicity-of-pneumococcal-conjugate-vaccine-in-preterm-infants-a-meta-analysis
#13
Kai Duan, Jin Guo, Ping Lei
OBJECTIVE: To assess the safety and immunogenicity of pneumococcal conjugate vaccine (PCVs) in preterm infants. METHODS: In accordance with the PRISM (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement (as of May 2015), a meta-analysis was conducted to evaluate the safety and immunogenicity of PCVs in preterm infants. RESULTS: Ten thousand nine hundred sixty full-term infants and 2131 preterm infants with 344 preterm infants of <2500 g birth weight [low-birth weight (LBW)] were included, and all the subjects were immunized with either PCV-7, PCV-10 or PCV-13 in this random-effects meta-analysis...
November 7, 2016: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/27815347/the-first-scube3-mutant-mouse-line-with-pleiotropic-phenotypic-alterations
#14
Helmut Fuchs, Sibylle Sabrautzki, Gerhard K H Przemeck, Stefanie Leuchtenberger, Bettina Lorenz-Depiereux, Lore Becker, Birgit Rathkolb, Marion Horsch, Lillian Garrett, Manuela A Östereicher, Wolfgang Hans, Koichiro Abe, Nobuho Sagawa, Jan Rozman, Ingrid L Vargas-Panesso, Michael Sandholzer, Thomas S Lisse, Thure Adler, Juan Antonio Aguilar-Pimentel, Julia Calzada-Wack, Nicole Ehrhard, Ralf Elvert, Christine Gau, Sabine M Hölter, Katja Micklich, Kristin Moreth, Cornelia Prehn, Oliver Puk, Ildiko Racz, Claudia Stoeger, Alexandra Vernaleken, Dian Michel, Susanne Diener, Thomas Wieland, Jerzy Adamski, Raffi Bekeredjian, Dirk H Busch, John Favor, Jochen Graw, Martin Klingenspor, Christoph Lengger, Holger Maier, Frauke Neff, Markus Ollert, Tobias Stoeger, Ali Önder Yildirim, Tim M Strom, Andreas Zimmer, Eckhard Wolf, Wolfgang Wurst, Thomas Klopstock, Johannes Beckers, Valerie Gailus-Durner, Martin Hrabě de Angelis
The vertebrate Scube (Signal peptide, CUB and EGF-like domain-containing protein) family consists of three independent members Scube1-3, which encode secreted cell surface-associated membrane glycoproteins. Limited information about the general function of this gene family is available, and their roles during adulthood. Here, we present the first Scube3 mutant mouse line (Scube3(N294K/N294K)) that clearly shows phenotypic alterations by carrying a missense mutation in exon 8, and thus contributes to understand SCUBE3 functions...
November 4, 2016: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/27806956/gmc-independence-is-a-great-british-compromise
#15
Abi Rimmer
No abstract text is available yet for this article.
November 2, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27790849/role-of-a-medical-student-patient-perspectives
#16
David Evans, Stephanie Owen, John Green
BACKGROUND: Medical students form an important part of the medical team; however, patients may not be fully aware of their role. Identifying students in the clinical setting is difficult because of their similar attire to other health care professionals. This parity may introduce unethical scenarios where patients may be speaking and consenting to individuals whom they do not recognise as students. METHODS: A single-sided questionnaire was given to hospital in-patients during a 12-week period...
October 28, 2016: Clinical Teacher
https://www.readbyqxmd.com/read/27789467/gmc-warns-of-state-of-unease-in-medical-profession
#17
Abi Rimmer
No abstract text is available yet for this article.
October 27, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27780630/effect-of-tdap-when-administered-before-with-or-after-the-13-valent-pneumococcal-conjugate-vaccine-coadministered-with-the-quadrivalent-meningococcal-conjugate-vaccine-in-adults-a-randomised-controlled-trial
#18
M Tashani, M Alfelali, O Barasheed, A S Alqahtani, L Heron, M Wong, H Rashid, R Booy
Sequential or co-administration of vaccines has potential to alter the immune response to any of the antigens. Existing literature suggests that prior immunisation of tetanus/diphtheria-containing vaccines can either enhance or suppress immune response to conjugate pneumococcal or meningococcal vaccines. We examined this interaction among adult Australian travellers before attending the Hajj pilgrimage 2014. We also investigated tolerability of these vaccines separately and concomitantly. We randomly assigned each participant to one of three vaccination schedules...
October 22, 2016: Vaccine
https://www.readbyqxmd.com/read/27762133/replacement-of-2-deoxycytidine-by-2-deoxycytidine-analogues-in-the-e-coli-genome
#19
Angad P Mehta, Han Li, Sean A Reed, Lubica Supekova, Tsotne Javahishvili, Peter G Schultz
Several modified bases have been observed in the genomic DNA of bacteriophages, prokaryotes, and eukaryotes that play a role in restriction systems and/or epigenetic regulation. In our efforts to understand the consequences of replacing a large fraction of a canonical nucleoside with a modified nucleoside, we previously replaced around 75% of thymidine (T) with 5'-hydroxymethyl-2'-deoxyuridine (5hmU) in the Escherichia coli genome. In this study, we engineered the pyrimidine nucleotide biosynthetic pathway using T4 bacteriophage genes to achieve approximately 63% replacement of 2'-deoxycytidine (dC) with 5-hydroxymethyl-2'-deoxycytidine (5hmC) in the E...
November 2, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27761153/involvement-of-fenton-chemistry-in-rice-straw-degradation-by-the-lignocellulolytic-bacterium-pantoea-ananatis-sd-1
#20
Jiangshan Ma, Keke Zhang, Mei Huang, Stanton B Hector, Bin Liu, Chunyi Tong, Qian Liu, Jiarui Zeng, Yan Gao, Ting Xu, Ying Liu, Xuanming Liu, Yonghua Zhu
BACKGROUND: Lignocellulolytic bacteria have revealed to be a promising source for biofuel production, yet the underlying mechanisms are still worth exploring. Our previous study inferred that the highly efficient lignocellulose degradation by bacterium Pantoea ananatis Sd-1 might involve Fenton chemistry (Fe(2+) + H2O2 + H(+) → Fe(3+) + OH· + H2O), similar to that of white-rot and brown-rot fungi. The aim of this work is to investigate the existence of this Fenton-based oxidation mechanism in the rice straw degradation process of P...
2016: Biotechnology for Biofuels
keyword
keyword
20688
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"