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https://www.readbyqxmd.com/read/28818080/standardized-systemic-phenotypic-analysis-reveals-kidney-dysfunction-as-main-alteration-of-kctd1-i27n-mutant-mice
#1
Sudhir Kumar, Birgit Rathkolb, Sibylle Sabrautzki, Stefan Krebs, Elisabeth Kemter, Lore Becker, Johannes Beckers, Raffi Bekeredjian, Robert Brommage, Julia Calzada-Wack, Lillian Garrett, Sabine M Hölter, Marion Horsch, Martin Klingenspor, Thomas Klopstock, Kristin Moreth, Frauke Neff, Jan Rozman, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabe de Angelis, Eckhard Wolf, Bernhard Aigner
BACKGROUND: Increased levels of blood plasma urea were used as phenotypic parameter for establishing novel mouse models for kidney diseases on the genetic background of C3H inbred mice in the phenotype-driven Munich ENU mouse mutagenesis project. The phenotypically dominant mutant line HST014 was established and further analyzed. METHODS: Analysis of the causative mutation as well as the standardized, systemic phenotypic analysis of the mutant line was carried out...
August 17, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28811838/ethical-religion-in-primary-care
#2
Malcolm Torry
Religion is increasingly significant in UK society, and is highly significant for many patients and primary care practitioners. An important task for the practitioner is to ensure that the place of religion in the patient/practitioner relationship is treated with the same ethical seriousness as every other aspect of that relationship. The article finds the 'four principles of biomedical ethics' to be applicable, and recent GMC guidelines to be consistent with the four principles. The article applies the four principles to the particular case of practitioners wearing religious symbolism...
July 2017: London Journal of Primary Care
https://www.readbyqxmd.com/read/28808110/moving-point-of-gmc-registration-is-out-of-remit-of-training-review-body
#3
Abi Rimmer
No abstract text is available yet for this article.
August 14, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28803502/immunogenicity-antibody-persistence-and-safety-of-the-60%C3%A2-%C3%AE-g-hepatitis-b-vaccine-in-hemodialysis-patients-a-multicenter-randomized-double-blind-parallel-controlled-trial
#4
Yongliang Feng, Xiaohong Shi, Jing Shi, Linying Gao, Guangming Liu, Yanpeng Cheng, Minghu Pan, Chunxia Li, Jun Wang, Xuxia Guo, Yawei Zhang, Xiaofeng Liang, Suping Wang
BACKGROUND: To evaluate the immunogenicity, antibody persistence, and safety of the 60 µg hepatitis B vaccine in hemodialysis patients in China. METHODS: We conducted a multicenter, randomized, double-blind, parallel-controlled trial including 352 hemodialysis patients who were centrally randomized in a ratio of 1:1 to receive a 20 µg (IM20 group) or 60 µg (IM60 group) recombinant hepatitis B vaccine at months 0, 1, and 6. RESULTS: The vaccine-elicited antibody responses peaked at month 7, and declined at month 12...
August 21, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28801343/trainee-gp-who-was-warned-over-falsifying-timesheets-to-get-new-sanction-after-gmc-appeal
#5
Clare Dyer
No abstract text is available yet for this article.
August 11, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28791415/impacts-of-the-serum-containing-total-flavonoids-of-ajuga-on-rat-glomerular-mesangial-cells
#6
Lihong Nan, Mei Huang, Wenfang Lai, Ru Jia, Yanfang Zheng, Lan Yang, Qingqing Xie, Weihua Peng
The aim of the current study was to investigate the impacts and possible mechanisms of total flavonoids of Ajuga (TFA) on glomerular mesangial cells (GMC) through in vitro observations of the impacts of TFA‑containing serum on GMC proliferation and extracellular matrix (ECM) secretion in lipopolysaccharides (LPS)‑induced rats. Rat GMC was cultured in vitro, using LPS to stimulate the proliferation of GMC and the secretion of ECM; meanwhile, TFA‑containing serum (TFA‑S) was used for the intervention...
August 8, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28759077/a-highly-conductive-carbon-sulfur-film-with-interconnected-mesopores-as-an-advanced-cathode-for-lithium-sulfur-batteries
#7
Mingkai Liu, Yuqing Liu, Yan Yan, Fengsheng Wang, Jiahui Liu, Tianxi Liu
A highly conductive graphene sheet-mesoporous carbon (MC) sphere/active sulfur (GMC-S) film, with MC-sulfur spheres as "active islands" and graphene sheets as "trapping nets", exhibits good cycling stability (500 cycles, with a capacity retention of 85%) with a high specific capacity of 1322 mA h g(-1) at 0.1C.
July 31, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28739798/patient-care-is-at-risk-from-inadequate-handovers-gmc-finds
#8
Abi Rimmer
No abstract text is available yet for this article.
July 24, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28721119/educational-challenges-faced-by-international-medical-graduates-in-the-uk
#9
Ahmed Hashim
INTRODUCTION: International medical graduates (IMGs) in the UK constitute approximately one-quarter of the total number of doctors registered in the General Medical Council (GMC). The transition of IMGs into the health care system in the UK is accompanied by significant sociocultural and educational challenges. This study aims to explore the views of IMGs in medical training on the educational challenges they face. METHODS: This study was conducted in the Kent, Surrey and Sussex region in 2015...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/28704204/psychometric-analysis-of-the-swedish-version-of-the-general-medical-council-s-multi-source-feedback-questionnaires
#10
Jan-Eric Olsson, Fan Yang Wallentin, Eva Toth-Pal, Solvig Ekblad, Bo Christer Bertilson
Objectives: To determine the internal consistency and the underlying components of our translated and adapted Swedish version of the General Medical Council's multisource feedback questionnaires (GMC questionnaires) for physicians and to confirm which aspects of good medical practice the latent variable structure reflected. Methods: From October 2015 to March 2016, residents in family medicine in Sweden were invited to participate in the study and to use the Swedish version to perform self-evaluations and acquire feedback from both their patients and colleagues...
July 10, 2017: International Journal of Medical Education
https://www.readbyqxmd.com/read/28693082/-study-of-mumps-immunity-after-administrating-measles-mumps-rubella-vaccine-among-children-aged-2-7-years-old-in-jiangsu-province-in-2015
#11
Y B Liu, Y Hu, X Y Deng, Z G Wang, X Sun, P S Lu, H X Guo, F Y Tang, M H Zhou
Objective: To investigate the immunity to mumps after administrating measles-mumps-rubella vaccine (MMR) among children aged 2-7 years old in Jiangsu province in 2015. Methods: A total of 4 190 healthy children aged 2-7 years old, living in local places for at least 3 months, and having been vaccinated at least 1 dose MMR were recruited to the study from Wujin district of Changzhou city, Gaogang district of Taizhou city and Ganyu district of Lianyungang city by using stratified cluster random sampling method between September and November, 2015...
July 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28693011/comparaci%C3%A3-n-de-la-efectividad-de-ranibizumab-intrav%C3%A3-treo-para-el-tratamiento-del-edema-macular-diab%C3%A3-tico-en-ojos-vitrectomizados-y-no-vitrectomizados
#12
Yoshito Koyanagi, Shigeo Yoshida, Yoshiyuki Kobayashi, Yuki Kubo, Muneo Yamaguchi, Takahito Nakama, Shintaro Nakao, Yasuhiro Ikeda, Yuji Ohshima, Tatsuro Ishibashi, Kohhei Sonoda
Objetivo: Comparar la efectividad de ranibizumab intravítreo (RIV) para el tratamiento del edema macular diabético (EMD) en ojos con y sin vitrectomía previa. Procedimientos: Evaluamos de manera prospectiva la mejor agudeza visual corregida (MAVC) y el grosor macular central (GMC) tras el tratamiento con RIV durante 6 meses. Resultados: No se observaron diferencias significativas en la MAVC o GMC inicial en ninguno de los dos grupos. En el grupo no vitrectomizado (n = 15), los cambios medios en la MAVC y GMC hasta el sexto mes de tratamiento con respecto al valor inicial resultaron significativos (p < 0,01)...
July 11, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28681172/whither-surgical-quality-assurance-of-breast-cancer-surgery-surgical-margins-and-local-recurrence-after-paterson
#13
EDITORIAL
N J Bundred, J Thomas, J M J Dixon
The Kennedy report into the actions of the disgraced Breast Surgeon, Paterson focussed on issues of informed consent for mastectomy, management of surgical margins and raised concerns about local recurrence rates and the increasing emphasis on cosmesis after mastectomy for breast cancer. This article assesses whether Kennedy's recommendations apply to the UK as a whole and how to address these issues. New GMC advice on consent and newer nonevidenced innovations in immediate reconstruction have altered the level of informed consent required...
July 5, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28676559/a-third-of-junior-doctors-say-rota-gaps-have-worsened-their-training-gmc-finds
#14
Abi Rimmer
No abstract text is available yet for this article.
July 4, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28668953/iga-enhances-igf-1-mitogenic-activity-via-receptor-modulation-in-glomerular-mesangial-cells-implications-for-iga-induced-nephropathy
#15
Amal Al-Eisa, Gursev S Dhaunsi
BACKGROUND/AIM: Glomerulonephritis due to mesangial proliferation is responsible for renal dysfunction in IgA nephropathy (IgAN), however molecular mechanisms of pathogenesis are not well known. We examined the effect of IgA on Insulin-like Growth Factor-1 (IGF-1) activity, a potent mitogen with vital role in growth and development of children, and IGF-1 receptor (IGF-1R) in cultures of glomerular mesangial cells (GMC). METHODS: GMC were isolated from rat kidneys using sieving and enzymatic digestion of tissue homogenates, and cultured in RPMI 1640 medium...
June 27, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28659030/tongxinluo-inhibits-renal-fibrosis-in-diabetic-nephropathy-involvement-of-the-suppression-of-intercellular-transfer-of-tgf-formula-see-text-1-containing-exosomes-from-gecs-to-gmcs
#16
Xiao-Ming Wu, Yan-Bin Gao, Li-Ping Xu, Da-Wei Zou, Zhi-Yao Zhu, Xiao-Lei Wang, Wei-Jie Yao, Liang-Tao Luo, Yu Tong, Nian-Xiu Tian, Zhe-Ji Han, Wan-Yu Dang
Glomerular mesangial cells (GMCs) activation is implicated in the pathogenesis of diabetic nephropathy (DN). Our previous study revealed that high glucose (HG)-treated glomerular endothelial cells (GECs) produce an increased number of TGF-β1-containing exosomes to activate GMCs through the TGF-β1/Smad3 signaling pathway. We also identified that Tongxinluo (TXL), a traditional Chinese medicine, has beneficial effects on the treatment of DN in DN patients and type 2 diabetic mice. However, it remained elusive whether TXL could ameliorate renal structure and function through suppression of intercellular transfer of TGF-β1-containing exosomes from GECs to GMCs...
June 28, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28652392/bma-annual-meeting-gmc-must-recognise-that-a-lack-of-resources-puts-doctors-at-risk-of-mistakes-says-the-bma
#17
Abi Rimmer
No abstract text is available yet for this article.
June 26, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28651839/post-vaccination-serologic-testing-of-infants-born-to-hepatitis-b-surface-antigen-positive-mothers-in-4-provinces-of-china
#18
Fuzhen Wang, Guomin Zhang, Hui Zheng, Ning Miao, Liping Shen, Feng Wang, Pumei Dong, Fei Du, Chao Chen, Xiaoshu Zhang, Fuqiang Cui
OBJECTIVE: To evaluate prenatal maternal hepatitis B virus (HBV) screening and post-vaccination hepatitis B surface antigen (HBsAg) and antibody to hepatitis B surface antigen (anti-HBs) status and titers of babies born to HBsAg positive mothers, and to provide evidence for development of standard postvaccination serologic testing (PVST) strategies for babies born to HBsAg positive mothers in China. METHODS: In 2014, we conducted a baseline survey of HBV mother to child transmission (MTCT) interruption strategy implementation and PVST for babies born to HBsAg positive mothers after received 3 doses of hepatitis B vaccine (HepB) in 8 counties in 4 Provinces...
July 24, 2017: Vaccine
https://www.readbyqxmd.com/read/28651399/-immune-response-to-one-booster-dose-of-inactivated-hepatitis-a-vaccine-in-college-students
#19
Z Liao, X W Feng, X E Liu, Y S Zhou, H R Wen, S H Peng, Y X Zhang, B Xu, H Zhuang, H Y Chen
Objective: To evaluate the safety and immunogenicity of one booster dose of inactivated hepatitis A vaccine in young adults. Methods: The subjects were selected from participants in the clinical trial of immunogenicity of inactivated and attenuated live hepatitis A vaccine in young adults. Eligible subjects were those who had received one dose of inactivated or attenuated hepatitis A vaccine, could be contacted and were sero-negative before primary vaccination. All qualified subjects were immunized with one booster dose of inactivated hepatitis A vaccine...
May 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28627566/theoretical-study-of-one-electron-oxidized-salen-complexes-of-group-7-mn-iii-tc-iii-and-re-iii-and-group-10-metals-ni-ii-pd-ii-and-pt-ii-with-the-3d-rism-gmc-qdpt-method-localized-vs-delocalized-ground-and-excited-states-in-solution
#20
Shinji Aono, Masayuki Nakagaki, Shigeyoshi Sakaki
One-electron oxidized salen complexes of Mn(iii) and Ni(ii) were recently reported to be unique mixed-valence compounds. Their electronic structures are sensitive to the salen ligand and solvation. We systematically investigated a series of one-electron oxidized salen complexes of group 7 metals (Mn(iii), Tc(iii), and Re(iii)) and their group 10 analogues (Ni(ii), Pd(ii), and Pt(ii)) using the general multi-configuration reference quasi-degenerate perturbation theory (GMC-QDPT) which was combined with the three-dimensional reference interaction site model self-consistent field theory (3D-RISM-SCF) to incorporate the solvation effect...
June 28, 2017: Physical Chemistry Chemical Physics: PCCP
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