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https://www.readbyqxmd.com/read/29054729/hib-antibody-responses-in-infants-following-diphtheria-tetanus-acellular-pertussis-and-conjugated-haemophilus-influenzae-type-b-hib-combination-vaccines-with-decreasing-amounts-of-tetanus-toxoid
#1
Henry H Bernstein, Elisabeth R Seyferth
BACKGROUND: While combination vaccines have contributed to improved vaccine uptake rates in children, studies have documented varied immunogenicity to specific vaccine components. We studied whether varying the amount of tetanus toxoid (TT) in a DTaP and Hib combination vaccine would result in immunogenicity comparable with separate, concurrent administration. METHODS: We evaluated the immunogenicity of Massachusetts Biologic Laboratories (MBL) diphtheria, tetanus, and acellular pertussis (mDTaP) vaccine combined with tetanus-conjugated MBL Haemophilus influenzae type b vaccine (mHib) in a single injection (DTaPH)...
October 17, 2017: Vaccine
https://www.readbyqxmd.com/read/29048697/comparison-of-arthroscopic-versus-open-surgery-on-external-snapping-hip-caused-by-gluteal-muscle-contracture
#2
Zhu Dai, Zhiwei Chen, Ying Liao, Zhengwu Tang, Juncheng Cui
PURPOSE: To compare the outcomes of contracture release by arthroscopic versus open surgical approach in patients with external snapping hip (ESH) caused by gluteal muscle contracture (GMC). METHODS: Medical records of patients with ESH due to GMC who underwent open surgery (n = 44) or arthroscopic surgery (n = 48) between October 2008 and October 2014 were reviewed. Patients were followed up at 1, 3, 12, and 24 months postoperatively. Operation time, incision length, postoperative pain, postoperative complication rate, and recurrence rate were compared between the 2 groups...
October 16, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29029122/immunogenicity-and-safety-of-the-hz-su-adjuvanted-herpes-zoster-subunit-vaccine-in-adults-previously-vaccinated-with-a-live-attenuated-herpes-zoster-vaccine
#3
Katrijn Grupping, Laura Campora, Martine Douha, Thomas C Heineman, Nicola P Klein, Himal Lal, James Peterson, Ilse Vastiau, Lidia Oostvogels
Background: Protection against herpes zoster (HZ) induced by the live-attenuated zoster vaccine Zostavax (ZVL) wanes within 3-7 years. Re-vaccination may renew protection. We assessed whether (re)-vaccination with the adjuvanted HZ subunit vaccine candidate (HZ/su) induced comparable immune responses in previous ZVL-recipients and ZVL-naïve individuals (HZ-NonVac). Methods: In an open-label, multicenter study (NCT02581410), adults ≥65 years of age, vaccinated with ZVL ≥5 years previously (HZ-PreVac), were matched to HZ-NonVac adults...
September 26, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29020321/comparison-of-a-novel-human-rabies-monoclonal-antibody-to-human-rabies-immunoglobulin-for-post-exposure-prophylaxis-a-phase-2-3-randomized-single-blind-non-inferiority-controlled-study
#4
Nithya J Gogtay, Renuka Munshi, D H Ashwathnarayan, B J Mahendra, Vikas Kshirsagar, Bhagwat Gunale, Susan Moore, Peter Cheslock, Saket Thaker, Siddharth Deshpande, Sunil Karande, Dipti Kumbhar, Ravish H S, B R Harish, Sambhaji S Pisal, Rajeev Dhere, Varsha Parulekar, William C Blackwelder, Deborah C Molrine, Prasad S Kulkarni
Background: Lack of access to rabies immunoglobulin (RIG) contributes to the high rabies mortality. A recombinant human monoclonal antibody (SII RMAb) was tested in a post-exposure prophylaxis (PEP) regimen in comparison to a human RIG (HRIG)-containing PEP regimen. Methods: This was a Phase 2/3 randomized, single blind, non-inferiority study conducted in 200 participants with WHO category III suspected rabies exposures. On Day 0, participants received either SII RMAb or HRIG (1:1 ratio) into wounds and if required, intramuscularly (IM) along with five doses of rabies vaccine IM on Days 0, 3, 7, 14 and 28...
September 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29018368/biclustered-independent-component-analysis-for-complex-biomarker-and-subtype-identification-from-structural-magnetic-resonance-images-in-schizophrenia
#5
Cota Navin Gupta, Eduardo Castro, Srinivas Rachkonda, Theo G M van Erp, Steven Potkin, Judith M Ford, Daniel Mathalon, Hyo Jong Lee, Bryon A Mueller, Douglas N Greve, Ole A Andreassen, Ingrid Agartz, Andrew R Mayer, Julia Stephen, Rex E Jung, Juan Bustillo, Vince D Calhoun, Jessica A Turner
Clinical and cognitive symptoms domain-based subtyping in schizophrenia (Sz) has been critiqued due to the lack of neurobiological correlates and heterogeneity in symptom scores. We, therefore, present a novel data-driven framework using biclustered independent component analysis to detect subtypes from the reliable and stable gray matter concentration (GMC) of patients with Sz. The developed methodology consists of the following steps: source-based morphometry (SBM) decomposition, selection and sorting of two component loadings, subtype component reconstruction using group information-guided ICA (GIG-ICA)...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28988741/smad7-alleviates-glomerular-mesangial-cell-proliferation-via-the-ros-nf-%C3%AE%C2%BAb-pathway
#6
Nana Lin, Zequan Ji
OBJECTIVE: The aim of this study was to demonstrate that altered gene expression of Smad7regulated NF-κB expression and ROS production on Ang II (Angiotensin II)-induced rat glomerular mesangial cell (GMC) proliferation. METHODS: pAdTrack-CMV-Smad7 was transduced into rat GMC by adeno-transduction using an ADV (adenovirus)-mediated vector in vivo. Diphenylene iodonium chloride (DPI) pre-treated GMC, and blocked ROS generation as determined by DCFH-DA method. Altered expressions of IκBα and p65 were monitored by Western blot analysis and immunofluorescence...
October 5, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28987445/immunogenicity-and-safety-of-an-inactivated-quadrivalent-influenza-vaccine-co-administered-with-a-23-valent-pneumococcal-polysaccharide-vaccine-versus-separate-administration-in-adults-%C3%A2-50years-of-age-results-from-a-phase-iii-randomized-non-inferiority-trial
#7
Opokua Ofori-Anyinam, Geert Leroux-Roels, Mamadou Drame, Annelies Aerssens, Cathy Maes, Arshad Amanullah, Anne Schuind, Ping Li, Varsha K Jain, Bruce L Innis
INTRODUCTION: We compared co-administration versus separate administration of an inactivated quadrivalent influenza vaccine (IIV4) with a 23-valent pneumococcal polysaccharide vaccine (PPV23) in adults at high risk of complications of influenza and pneumococcal infection. METHODS: This phase III, placebo-controlled, observer-blind trial (NCT02218697) was conducted in France and Belgium during the 2014-2015 influenza season. Adults≥50years of age meeting their country's vaccination recommendations were randomized 1:1 to co-administration or separate administration...
October 5, 2017: Vaccine
https://www.readbyqxmd.com/read/28974491/judge-questions-why-gmc-took-three-years-to-investigate-sexual-assault-claim
#8
Clare Dyer
No abstract text is available yet for this article.
October 3, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28966146/understanding-gene-functions-and-disease-mechanisms-phenotyping-pipelines-in-the-german-mouse-clinic
#9
REVIEW
Helmut Fuchs, Juan Antonio Aguilar-Pimentel, Oana V Amarie, Lore Becker, Julia Calzada-Wack, Yi-Li Cho, Lillian Garrett, Sabine M Hölter, Martin Irmler, Martin Kistler, Markus Kraiger, Philipp Mayer-Kuckuk, Kristin Moreth, Birgit Rathkolb, Jan Rozman, Patricia da Silva Buttkus, Irina Treise, Annemarie Zimprich, Kristine Gampe, Christine Hutterer, Stefanie Leuchtenberger, Holger Maier, Manuel Miller, Angelika Scheideler, Moya Wu, Johannes Beckers, Raffi Bekeredjian, Markus Brielmeier, Dirk H Busch, Martin Klingenspor, Thomas Klopstock, Markus Ollert, Carsten Schmidt-Weber, Tobias Stoeger, Eckhard Wolf, Wolfgang Wurst, Ali Önder Yildirim, Andreas Zimmer, Valérie Gailus-Durner, Martin Hrabě de Angelis
Since decades, model organisms have provided an important approach for understanding the mechanistic basis of human diseases. The German Mouse Clinic (GMC) was the first phenotyping facility that established a collaboration-based platform for phenotype characterization of mouse lines. In order to address individual projects by a tailor-made phenotyping strategy, the GMC advanced in developing a series of pipelines with tests for the analysis of specific disease areas. For a general broad analysis, there is a screening pipeline that covers the key parameters for the most relevant disease areas...
September 28, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28925480/the-role-of-pten-up-regulation-in-suppressing-glomerular-mesangial-cells-proliferation-and-nephritis-pathogenesis
#10
H-Y Gao, C-X Han
OBJECTIVE: Over-proliferation of mesangial cells is the major pathological change of mesangial proliferative glomerulonephritis (MPGN). PTEN-PI3K/AKT pathway plays a role in regulating proliferation of mesangial cells. Anti-thymocyte serum nephritis (ATSN) is a widely used animal model for studying MPGN. This study established ATSN model, on which the role of PTEN-PI3K/AKT signal pathway in MPGN pathogenesis was investigated. MATERIALS AND METHODS: ASTN rat model was established in parallel with control group...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28899905/on-revalidation-the-gmc-is-listening-to-you
#11
Terence Stephenson
No abstract text is available yet for this article.
September 12, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28871126/mdm2-contributes-to-high-glucose-induced-glomerular-mesangial-cell-proliferation-and-extracellular-matrix-accumulation-via-notch1
#12
Chun-Tao Lei, Hui Tang, Chen Ye, Chao-Qun You, Jiao Zhang, Chun-Yun Zhang, Wei Xiong, Hua Su, Chun Zhang
Murine double minute 2 (MDM2) is an E3-ubiquitin ligase critical for various biological functions. Previous data have revealed an indispensable role of MDM2 in kidney homeostasis. However, its role in glomerular mesangial cell (GMC) proliferation and extracellular matrix (ECM) accumulation during hyperglycemia condition remains unclear. In our present study, we found that MDM2 protein level was significantly upregulated in high glucose-treated GMCs, while knocking down MDM2 by siRNA could attenuate high glucose-induced ECM accumulation and GMCs proliferation...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28864596/doctors-use-of-facebook-twitter-and-whatsapp-is-the-focus-of-28-gmc-investigations
#13
Abi Rimmer
No abstract text is available yet for this article.
September 1, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28851685/junior-doctors-are-threatened-with-gmc-referral-for-refusing-locum-work
#14
Abi Rimmer
No abstract text is available yet for this article.
August 29, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28842473/gmc-appeals-decision-not-to-strike-off-doctor-convicted-of-manslaughter
#15
Clare Dyer
No abstract text is available yet for this article.
August 25, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28838125/hothead-like-hth1-is-involved-in-anther-cutin-biosynthesis-and-is-required-for-pollen-fertility-in-rice
#16
Ya Xu, Shasha Liu, Yaqin Liu, Sheng Ling, Caisheng Chen, Jialing Yao
The cuticle covering the outer surface of anthers is essential for male reproductive development in plants. However, the mechanism underlying the synthesis of these lipidic polymers remains unclear. HOTHEAD (HTH) in Arabidopsis thaliana is a presumptive glucose-methanol-choline (GMC) oxidoreductase involved in the biosynthesis of long-chain α-,ω-dicarboxylic fatty acids. In this study, we characterized the function of an anther-specific gene HTH1 in rice. HTH1 contains a conserved GMC oxidoreductase-like domain, and the sequence of HTH1 was highly similar to that of HTH in A...
July 1, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28818080/standardized-systemic-phenotypic-analysis-reveals-kidney-dysfunction-as-main-alteration-of-kctd1-i27n-mutant-mice
#17
Sudhir Kumar, Birgit Rathkolb, Sibylle Sabrautzki, Stefan Krebs, Elisabeth Kemter, Lore Becker, Johannes Beckers, Raffi Bekeredjian, Robert Brommage, Julia Calzada-Wack, Lillian Garrett, Sabine M Hölter, Marion Horsch, Martin Klingenspor, Thomas Klopstock, Kristin Moreth, Frauke Neff, Jan Rozman, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabe de Angelis, Eckhard Wolf, Bernhard Aigner
BACKGROUND: Increased levels of blood plasma urea were used as phenotypic parameter for establishing novel mouse models for kidney diseases on the genetic background of C3H inbred mice in the phenotype-driven Munich ENU mouse mutagenesis project. The phenotypically dominant mutant line HST014 was established and further analyzed. METHODS: Analysis of the causative mutation as well as the standardized, systemic phenotypic analysis of the mutant line was carried out...
August 17, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28811838/ethical-religion-in-primary-care
#18
Malcolm Torry
Religion is increasingly significant in UK society, and is highly significant for many patients and primary care practitioners. An important task for the practitioner is to ensure that the place of religion in the patient/practitioner relationship is treated with the same ethical seriousness as every other aspect of that relationship. The article finds the 'four principles of biomedical ethics' to be applicable, and recent GMC guidelines to be consistent with the four principles. The article applies the four principles to the particular case of practitioners wearing religious symbolism...
July 2017: London Journal of Primary Care
https://www.readbyqxmd.com/read/28808110/moving-point-of-gmc-registration-is-out-of-remit-of-training-review-body
#19
Abi Rimmer
No abstract text is available yet for this article.
August 14, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28803502/immunogenicity-antibody-persistence-and-safety-of-the-60%C3%A2-%C3%AE-g-hepatitis-b-vaccine-in-hemodialysis-patients-a-multicenter-randomized-double-blind-parallel-controlled-trial
#20
Yongliang Feng, Xiaohong Shi, Jing Shi, Linying Gao, Guangming Liu, Yanpeng Cheng, Minghu Pan, Chunxia Li, Jun Wang, Xuxia Guo, Yawei Zhang, Xiaofeng Liang, Suping Wang
BACKGROUND: To evaluate the immunogenicity, antibody persistence, and safety of the 60 µg hepatitis B vaccine in hemodialysis patients in China. METHODS: We conducted a multicenter, randomized, double-blind, parallel-controlled trial including 352 hemodialysis patients who were centrally randomized in a ratio of 1:1 to receive a 20 µg (IM20 group) or 60 µg (IM60 group) recombinant hepatitis B vaccine at months 0, 1, and 6. RESULTS: The vaccine-elicited antibody responses peaked at month 7, and declined at month 12...
August 21, 2017: Expert Review of Vaccines
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