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https://www.readbyqxmd.com/read/29242182/gmc-cuts-junior-doctors-registration-fees
#1
Abi Rimmer
No abstract text is available yet for this article.
December 14, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29233807/gmc-says-that-it-should-regulate-physician-associates
#2
Abi Rimmer
No abstract text is available yet for this article.
December 12, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29222497/computational-insights-for-the-hydride-transfer-and-distinctive-roles-of-key-residues-in-cholesterol-oxidase
#3
Li-Juan Yu, Emily Golden, Nanhao Chen, Yuan Zhao, Alice Vrielink, Amir Karton
Cholesterol oxidase (ChOx), a member of the glucose-methanol-choline (GMC) family, catalyzes the oxidation of the substrate via a hydride transfer mechanism and concomitant reduction of the FAD cofactor. Unlike other GMC enzymes, the conserved His447 is not the catalytic base that deprotonates the substrate in ChOx. Our QM/MM MD simulations indicate that the Glu361 residue acts as a catalytic base facilitating the hydride transfer from the substrate to the cofactor. We find that two rationally chosen point mutations (His447Gln and His447Asn) cause notable decreases in the catalytic activity...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29222125/gmc-begins-high-court-appeal-over-suspension-of-paediatrician-convicted-of-manslaughter
#4
Clare Dyer
No abstract text is available yet for this article.
December 8, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29180512/junior-doctors-are-being-left-to-run-hospital-departments-unsupervised-gmc-warns
#5
Gareth Iacobucci
No abstract text is available yet for this article.
November 27, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29174323/pneumococcal-conjugate-vaccine-13-delivered-as-one-primary-and-one-booster-dose-1%C3%A2-%C3%A2-1-compared-with-two-primary-doses-and-a-booster-2%C3%A2-%C3%A2-1-in-uk-infants-a-multicentre-parallel-group-randomised-controlled-trial
#6
David Goldblatt, Jo Southern, Nick J Andrews, Polly Burbidge, Jo Partington, Lucy Roalfe, Marta Valente Pinto, Vasilli Thalasselis, Emma Plested, Hayley Richardson, Matthew D Snape, Elizabeth Miller
BACKGROUND: Infants in the UK were first offered a pneumococcal conjugate vaccine (PCV7) in 2006, given at 2 and 4 months of age and a booster dose at 13 months (2 + 1 schedule). A 13-valent vaccine (PCV13) replaced PCV7 in 2010. We aimed to compare the post-booster antibody response in UK infants given a reduced priming schedule of PCV13 (ie, a 1 + 1 schedule) versus the current 2 + 1 schedule and to assess the potential effect on population protection. METHODS: In this multicentre, parallel group, randomised controlled trial, we recuited infants due to receive their primary immunisations aged up to 13 weeks on first vaccinations by information booklets mailed out via the NHS Child Health Information Service and the UK National Health Application and Infrastructure Services...
November 22, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29162606/support-mounts-for-paediatrician-whom-gmc-wants-struck-off
#7
Deborah Cohen
No abstract text is available yet for this article.
November 21, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29157254/the-implementation-of-medical-revalidation-an-assessment-using-normalisation-process-theory
#8
Abigail Tazzyman, Jane Ferguson, Charlotte Hillier, Alan Boyd, John Tredinnick-Rowe, Julian Archer, Sam Regan de Bere, Kieran Walshe
BACKGROUND: Medical revalidation is the process by which all licensed doctors are legally required to demonstrate that they are up to date and fit to practise in order to maintain their licence. Revalidation was introduced in the United Kingdom (UK) in 2012, constituting significant change in the regulation of doctors. The governing body, the General Medical Council (GMC), envisages that revalidation will improve patient care and safety. This potential however is, in part, dependent upon how successfully revalidation is embedded into routine practice...
November 21, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29153585/identify-the-susceptibility-profile-to-measles-in-the-general-population-serological-survey-of-measles-antibodies-in-shaanxi-province-china-in-2016
#9
Lin Pei, Yuxuan Yang, Xiaodan Zhao, Shaobai Zhang, Lingyun Yuan, Yamei Liu, Yan Yu
The reported coverage with two doses of the measles vaccine (MCV) in Shaanxi Province, China, is greater than 95%, but the measles incidence over the whole province remains high. Cross-sectional serological surveys of measles antibodies in Shaanxi Province were conducted in 2016 to assess the population's immunity. The measles IgG levels were measured in serum samples using ELISA. The geometric means concentration (GMC) levels and seroprevalence rates with 95% CIs were calculated by region, gender, and age...
November 15, 2017: Vaccine
https://www.readbyqxmd.com/read/29122746/gmc-to-push-for-erasure-of-paediatrician-convicted-of-manslaughter
#10
Clare Dyer
No abstract text is available yet for this article.
November 9, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29092822/doctor-wins-right-to-take-gmc-to-employment-tribunal
#11
Clare Dyer
No abstract text is available yet for this article.
November 1, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29079649/gmc-is-criticised-for-failing-to-properly-investigate-case-against-cosmetic-surgeon
#12
Clare Dyer
No abstract text is available yet for this article.
October 27, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29074700/northern-ireland-trainees-are-well-supported-and-supervised-gmc-finds
#13
Abi Rimmer
No abstract text is available yet for this article.
October 26, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29054729/hib-antibody-responses-in-infants-following-diphtheria-tetanus-acellular-pertussis-and-conjugated-haemophilus-influenzae-type-b-hib-combination-vaccines-with-decreasing-amounts-of-tetanus-toxoid
#14
Henry H Bernstein, Elisabeth R Seyferth
BACKGROUND: While combination vaccines have contributed to improved vaccine uptake rates in children, studies have documented varied immunogenicity to specific vaccine components. We studied whether varying the amount of tetanus toxoid (TT) in a DTaP and Hib combination vaccine would result in immunogenicity comparable with separate, concurrent administration. METHODS: We evaluated the immunogenicity of Massachusetts Biologic Laboratories (MBL) diphtheria, tetanus, and acellular pertussis (mDTaP) vaccine combined with tetanus-conjugated MBL Haemophilus influenzae type b vaccine (mHib) in a single injection (DTaPH)...
October 17, 2017: Vaccine
https://www.readbyqxmd.com/read/29048697/comparison-of-arthroscopic-versus-open-surgery-on-external-snapping-hip-caused-by-gluteal-muscle-contracture
#15
Zhu Dai, Zhiwei Chen, Ying Liao, Zhengwu Tang, Juncheng Cui
PURPOSE: To compare the outcomes of contracture release by arthroscopic versus open surgical approach in patients with external snapping hip (ESH) caused by gluteal muscle contracture (GMC). METHODS: Medical records of patients with ESH due to GMC who underwent open surgery (n = 44) or arthroscopic surgery (n = 48) between October 2008 and October 2014 were reviewed. Patients were followed up at 1, 3, 12, and 24 months postoperatively. Operation time, incision length, postoperative pain, postoperative complication rate, and recurrence rate were compared between the 2 groups...
October 16, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29029122/immunogenicity-and-safety-of-the-hz-su-adjuvanted-herpes-zoster-subunit-vaccine-in-adults-previously-vaccinated-with-a-live-attenuated-herpes-zoster-vaccine
#16
Katrijn Grupping, Laura Campora, Martine Douha, Thomas C Heineman, Nicola P Klein, Himal Lal, James Peterson, Ilse Vastiau, Lidia Oostvogels
Background: Protection against herpes zoster (HZ) induced by the live-attenuated zoster vaccine Zostavax (ZVL) wanes within 3-7 years. Re-vaccination may renew protection. We assessed whether (re)-vaccination with the adjuvanted HZ subunit vaccine candidate (HZ/su) induced comparable immune responses in previous ZVL-recipients and ZVL-naïve individuals (HZ-NonVac). Methods: In an open-label, multicenter study (NCT02581410), adults ≥65 years of age, vaccinated with ZVL ≥5 years previously (HZ-PreVac), were matched to HZ-NonVac adults...
September 26, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29020321/comparison-of-a-novel-human-rabies-monoclonal-antibody-to-human-rabies-immunoglobulin-for-post-exposure-prophylaxis-a-phase-2-3-randomized-single-blind-non-inferiority-controlled-study
#17
Nithya J Gogtay, Renuka Munshi, D H Ashwathnarayan, B J Mahendra, Vikas Kshirsagar, Bhagwat Gunale, Susan Moore, Peter Cheslock, Saket Thaker, Siddharth Deshpande, Sunil Karande, Dipti Kumbhar, Ravish H S, B R Harish, Sambhaji S Pisal, Rajeev Dhere, Varsha Parulekar, William C Blackwelder, Deborah C Molrine, Prasad S Kulkarni
Background: Lack of access to rabies immunoglobulin (RIG) contributes to the high rabies mortality. A recombinant human monoclonal antibody (SII RMAb) was tested in a post-exposure prophylaxis (PEP) regimen in comparison to a human RIG (HRIG)-containing PEP regimen. Methods: This was a Phase 2/3 randomized, single blind, non-inferiority study conducted in 200 participants with WHO category III suspected rabies exposures. On Day 0, participants received either SII RMAb or HRIG (1:1 ratio) into wounds and if required, intramuscularly (IM) along with five doses of rabies vaccine IM on Days 0, 3, 7, 14 and 28...
September 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29018368/biclustered-independent-component-analysis-for-complex-biomarker-and-subtype-identification-from-structural-magnetic-resonance-images-in-schizophrenia
#18
Cota Navin Gupta, Eduardo Castro, Srinivas Rachkonda, Theo G M van Erp, Steven Potkin, Judith M Ford, Daniel Mathalon, Hyo Jong Lee, Bryon A Mueller, Douglas N Greve, Ole A Andreassen, Ingrid Agartz, Andrew R Mayer, Julia Stephen, Rex E Jung, Juan Bustillo, Vince D Calhoun, Jessica A Turner
Clinical and cognitive symptoms domain-based subtyping in schizophrenia (Sz) has been critiqued due to the lack of neurobiological correlates and heterogeneity in symptom scores. We, therefore, present a novel data-driven framework using biclustered independent component analysis to detect subtypes from the reliable and stable gray matter concentration (GMC) of patients with Sz. The developed methodology consists of the following steps: source-based morphometry (SBM) decomposition, selection and sorting of two component loadings, subtype component reconstruction using group information-guided ICA (GIG-ICA)...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28988741/smad7-alleviates-glomerular-mesangial-cell-proliferation-via-the-ros-nf-%C3%AE%C2%BAb-pathway
#19
Nana Lin, Zequan Ji, Cuiwen Huang
OBJECTIVE: The aim of this study was to demonstrate that altered gene expression of Smad7regulated NF-κB expression and ROS production on Ang II (Angiotensin II)-induced rat glomerular mesangial cell (GMC) proliferation. METHODS: pAdTrack-CMV-Smad7 was transduced into rat GMC by adeno-transduction using an ADV (adenovirus)-mediated vector in vivo. Diphenylene iodonium chloride (DPI) pre-treated GMC, and blocked ROS generation as determined by DCFH-DA method. Altered expressions of IκBα and p65 were monitored by Western blot analysis and immunofluorescence...
October 6, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28987445/immunogenicity-and-safety-of-an-inactivated-quadrivalent-influenza-vaccine-co-administered-with-a-23-valent-pneumococcal-polysaccharide-vaccine-versus-separate-administration-in-adults-%C3%A2-50years-of-age-results-from-a-phase-iii-randomized-non-inferiority-trial
#20
Opokua Ofori-Anyinam, Geert Leroux-Roels, Mamadou Drame, Annelies Aerssens, Cathy Maes, Arshad Amanullah, Anne Schuind, Ping Li, Varsha K Jain, Bruce L Innis
INTRODUCTION: We compared co-administration versus separate administration of an inactivated quadrivalent influenza vaccine (IIV4) with a 23-valent pneumococcal polysaccharide vaccine (PPV23) in adults at high risk of complications of influenza and pneumococcal infection. METHODS: This phase III, placebo-controlled, observer-blind trial (NCT02218697) was conducted in France and Belgium during the 2014-2015 influenza season. Adults≥50years of age meeting their country's vaccination recommendations were randomized 1:1 to co-administration or separate administration...
November 1, 2017: Vaccine
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