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https://www.readbyqxmd.com/read/28208856/seroprevalence-of-common-viral-diseases-a-hospital-based-study-from-amritsar-india
#1
Kanwardeep Singh, Shailpreet K Sidhu, Pushpa Devi, Manpreet Kaur, Maninder Kaur, Nachhatarjit Singh
INTRODUCTION: There is a paucity of published data on epidemiology of the viral infections in Punjab, India. The Viral Research and Diagnostic Laboratory (VRDL) located at Government Medical College (GMC), Amritsar conducts the initial diagnosis of common viruses circulating in the region. AIM: To report the seroprevalence of various viral diseases in Amritsar and neighboring districts of Punjab along with the demographic and geographical data of the patients. MATERIALS AND METHODS: Whole blood sera samples from a total of 5781 patients suspected of various viral diseases (chikungunya, dengue, hepatitis A, hepatitis B, hepatitis C, hepatitis E, herpes simplex-1 or herpes simplex-2) were received at VRDL, GMC, Amritsar from January 2015 to April 2016 and a cross sectional study was conducted...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28206830/medical-student-beliefs-about-disclosure-of-mental-health-issues-a-qualitative-study
#2
Peter Winter, Andrew Rix, Andrew Grant
In 2012 the United Kingdom's General Medical Council (GMC) commissioned research to develop guidance for medical schools on how best to support students with mental illness. One of the key findings from medical student focus groups in the study was students' strong belief that medical schools excluded students on mental health grounds. Students believed mental illness was a fitness to practice matter that led to eventual dismissal, although neither personal experience nor empirical evidence supported this belief...
2017: Journal of Veterinary Medical Education
https://www.readbyqxmd.com/read/28148481/gmc-fires-warning-shot-to-protect-doctors-training
#3
Abi Rimmer
No abstract text is available yet for this article.
February 1, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28134742/will-infant-hepatitis-b-vaccination-protect-into-adulthood-extended-canadian-experience-after-a-2-4-6-month-immunization-schedule
#4
Michelle Pinto, Meena Dawar, Mel Krajden, Monika Naus, David W Scheifele
INTRODUCTION: Hepatitis B virus (HBV) vaccination programs generally target infants to prevent chronic HBV infection and/or pre-adolescents to reduce transmission in adulthood. To assess whether infant HBV immunization can potentially accomplish both objectives we measured residual immunity 10-16 years after vaccination in Canadian children. METHODS: A prospective, parallel group, single center study enrolled adolescents given HBV vaccine at 2, 4, and 6 months of age...
January 26, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28129459/corticosteroids-for-the-treatment-of-kawasaki-disease-in-children
#5
REVIEW
Andrew J Wardle, Georgia M Connolly, Matthew J Seager, Robert Mr Tulloh
BACKGROUND: Kawasaki disease (KD), or mucocutaneous syndrome, is the leading cause of childhood-acquired heart disease in the developed world. There is much controversy on how best to treat children with KD and in particular who may benefit from additional treatment beyond the standard intravenous immunoglobulin (IVIG) and aspirin, such as the addition of corticosteroids. OBJECTIVES: To assess the impact of corticosteroid use on the incidence of coronary artery abnormalities in KD as either first-line or second-line treatment...
January 27, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28126840/neuroblast-niche-position-is-controlled-by-pi3-kinase-dependent-de-cadherin-adhesion
#6
Susan E Doyle, Matthew C Pahl, Karsten H Siller, Lindsay Ardiff, Sarah E Siegrist
Correct positioning of stem cells within their niche is essential for tissue morphogenesis and homeostasis. Yet how stem cells acquire and maintain niche position remains largely unknown. Here, we show that a subset of brain neuroblasts (NBs) in Drosophila utilize PI3-kinase and DE-cadherin to build adhesive contact for NB niche positioning. NBs remain within their native microenvironment when levels of PI3-kinase activity and DE-cadherin are elevated in NBs. This occurs through PI3-kinase dependent regulation of DE-Cadherin mediated cell adhesion between NBs and neighboring cortex glia, and between NBs and their GMC daughters...
January 26, 2017: Development
https://www.readbyqxmd.com/read/28126835/high-workload-is-putting-doctors-professionalism-at-risk-says-gmc
#7
Tom Moberly
No abstract text is available yet for this article.
January 26, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28114315/the-lorazepam-and-diazepam-protocol-for-catatonia-due-to-general-medical-condition-and-substance-in-liaison-psychiatry
#8
Chin-Chuen Lin, Yi-Yung Hung, Meng-Chang Tsai, Tiao-Lai Huang
OBJECTIVE: The lorazepam-diazepam protocol had been proved to rapidly and effectively relieve catatonia in patients with schizophrenia or mood disorder. This study aims to investigate the efficacy of lorazepam-diazepam protocol in catatonia due to general medical conditions (GMC) and substance. METHOD: Patients with catatonia that required psychiatric intervention in various settings of a medical center were included. The lorazepam-diazepam protocol had been used to treat the catatonia due to GMC or substance according to DSM-IV criteria...
2017: PloS One
https://www.readbyqxmd.com/read/28104613/niall-dickson-from-bbc-to-gmc-to-nhs
#9
(no author information available yet)
No abstract text is available yet for this article.
January 19, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28092416/persistence-of-antibody-to-hepatitis-a-virus-20-years-after-receipt-of-hepatitis-a-vaccine-in-alaska
#10
Ian D Plumb, Lisa R Bulkow, Michael G Bruce, Thomas W Hennessy, Julie Morris, Karen Rudolph, Philip Spradling, Mary Snowball, Brian J McMahon
Hepatitis A vaccine is recommended for children ≥1 year old to prevent hepatitis A virus (HAV) infection. However the duration of vaccine-induced immunity is unknown. We evaluated a cohort of Alaska Native persons 20 years after HAV vaccination. Children aged 3-6 years had been previously randomized to receive 3 doses of HAV vaccine (360 ELISA units/dose) at: A) 0,1,2 months; B) 0,1,6 months; and C) 0,1,12 months. We measured anti-HAV antibody concentrations every 2-3 years; described geometric mean concentrations (GMC) and the proportion with protective antibody (≥20 mIU mL-1) over time; and modelled change in GMC using fractional polynomial regression...
January 16, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28087501/employers-should-not-add-management-objectives-to-revalidation-process-gmc-says
#11
Abi Rimmer
No abstract text is available yet for this article.
January 13, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28073776/managers-must-respond-to-doctors-patient-safety-concerns-gmc-says
#12
Tom Moberly
No abstract text is available yet for this article.
January 10, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28063006/therapeutic-value-of-nerve-growth-factor-in-promoting-neural-stem-cell-survival-and-differentiation-and-protecting-against-neuronal-hearing-loss
#13
Zhao Han, Cong-Pin Wang, Ning Cong, Yu-Yan Gu, Rui Ma, Fang-Lu Chi
Nerve growth factor (NGF) is a neurotrophic factor that modulates survival and differentiation of neural stem cells (NSCs). We investigated the function of NGF in promoting growth and neuronal differentiation of NSCs isolated from mouse cochlear tissue, as well as its protective properties against gentamicin (GMC) ototoxicity. NSCs were isolated from the cochlea of mice and cultured in vitro. Effect of NGF on survival, neurosphere formation, and differentiation of the NSCs, as well as neurite outgrowth and neural excitability in the subsequent in vitro neuronal network, was examined...
January 7, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28060048/a-randomized-controlled-trial-to-evaluate-a-potential-hepatitis-b-booster-vaccination-strategy-using-combined-hepatitis-a-and-b-vaccine
#14
Fangjun Li, Yuansheng Hu, Youming Zhou, Lixin Chen, Wei Xia, Yufei Song, Zhengliang Tan, Lidong Gao, Zhong Yang, Gang Zeng, Xing Han
BACKGROUND: Booster doses could play a major role in those no responders or low responders to primary hepatitis B vaccine. Planed time point for hepatitis A vaccination in China provides a good opportunity to carry out hepatitis B booster dose by using combined hepatitis A and B vaccine. METHOD: A randomized, double blinded clinical trial was conducted to compare the immunogenicity and safety of toddlers 18-24 months of age receiving three different vaccination regimens: either two doses of inactivated hepatitis A vaccine (group 1), or one dose inactivated hepatitis A vaccine plus one dose combined hepatitis A and B vaccine (group 2), or two doses of combined hepatitis A and B vaccine (group 3) respectively...
January 3, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28059055/gluteal-muscle-contracture-diagnosis-and-management-options
#15
Saroj Rai, Chunqing Meng, Xiaohong Wang, Nabin Chaudhary, Shengyang Jin, Shuhua Yang, Hong Wang
Gluteal muscle contracture (GMC), a debilitating disease, exists all over the globe but it is much more prevalent in China. Patients typically present with abduction and external rotation of the hip and are unable to bring both the knees together while squatting. Multiple etiologies have been postulated, the commonest being repeated intramuscular injection into the buttocks. The disease is diagnosed primarily by clinical features but radiological features are necessary for the exclusion of other pathological conditions...
2017: SICOT-J
https://www.readbyqxmd.com/read/28052572/an-undergraduate-otolaryngology-curriculum-comparison-in-the-united-kingdom-using-a-curriculum-evaluation-framework
#16
R A Steven, G J Mires, S K W Lloyd, S McAleer
OBJECTIVE: 1.To compare undergraduate Otolaryngology curricula in the United Kingdom. 2.To develop a tool which would allow undergraduate specialty curricula to be compared. DESIGN: Development of a Curriculum Evaluation Framework and survey. SETTING: UK medical schools. PARTICIPANTS: Otolaryngology curricula were requested from all 32 UK medical schools who award a primary medical qualification. 19 curricula were received and examined...
January 4, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28048688/su-f-t-155-validation-of-a-commercial-monte-carlo-dose-calculation-algorithm-for-proton-therapy
#17
J Saini, S St James, E Traneus, T Wong, R Stewart, C Bloch
PURPOSE: Compare proton pencil beam scanning dose measurements to GATE/GEANT4 (GMC) and RayStation™ Monte Carlo (RMC) simulations. METHODS: Proton pencil beam models of the IBA gantry at the Seattle Proton Therapy Center were developed in the GMC code system and a research build of the RMC. For RMC, a preliminary beam model that does not account for upstream halo was used. Depth dose and lateral profiles are compared for the RMC, GMC and a RayStation™ pencil beam dose (RPB) model for three spread out Bragg peaks (SOBPs) in homogenous water phantom...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045585/immunogenicity-and-safety-of-purified-vero-cell-rabies-vaccine-pvrv-produced-by-liaoning-cheng-da-co-under-zagreb-2-1-1-or-5-dose-essen-regimen-in-chinese-adults-aged-50-and-above
#18
Jing Wang, FengJi Luo, ZiJian Feng, Li Li, YunHua Bai, Xing Ai, JianXin Ma, Zheng Zhang, NianMin Shi
BACKGROUND: Two kinds of regimens (2-1-1 and 1-1-1-1-1) can be selected after Zagreb regimen(2-1-1)of PVRV was officially approved in Beijing in January 2015. Up to now, the subjects for most studies about the comparison between Zagreb and Essen regimen are under 50 y old, rarely at and above. Aging of the immune system may result in decreasing efficacy of vaccination, especially for adults aged above 65-70 y. This study compared the safety and immunogenicity of the Zagreb and Essen regimen in Chinese adults aged 50 and above with the goal to provide a supplemental data for this age group...
January 2, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28040688/prevalence-of-pertussis-antibodies-in-maternal-blood-cord-serum-and-infants-from-mothers-with-and-those-without-tdap-booster-vaccination-during-pregnancy-in-argentina
#19
Aurelia A Fallo, Silvina E Neyro, Gabriela V Manonelles, Claudia Lara, Daniela Hozbor, Jonathan Zintgraff, Silvina Mazzeo, Héctor E Davison, Susana González, Estella Zapulla, Oscar Canle, Miguel Huespe, Marcelo Galas, Eduardo L López
BACKGROUND: Morbidity and mortality rates for pertussis in infants are high because disease often occurs before the onset of routine immunization or in those who do not complete a primary immunization series. Pertussis immunization is recommended during pregnancy to achieve antibody levels sufficient to protect young infants. To our knowledge, no previous reports of maternal pertussis immunization results in Latin America exist in the literature. METHODS: This study compared pertussis antibody levels in newborns from mothers who received or did not receive a tetanus-diphtheria-acellular pertussis vaccination (TdapV) during pregnancy...
December 30, 2016: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28039298/sublytic-c5b-9-induces-glomerular-mesangial-cell-apoptosis-through-the-cascade-pathway-of-mekk2-p38-mapk-irf-1-tradd-caspase-8-in-rat-thy-1-nephritis
#20
Ganqian Zhu, Wen Qiu, Yongting Li, Chenhui Zhao, Fengxia He, Mengya Zhou, Lulu Wang, Dan Zhao, Yanlai Lu, Jing Zhang, Yu Liu, Tianyi Yu, Yingwei Wang
The apoptosis of glomerular mesangial cells (GMCs) in the early phase of rat Thy-1 nephritis (Thy-1N), a model of human mesangioproliferative glomerulonephritis (MsPGN), is primarily triggered by sublytic C5b-9. However, the mechanism of GMC apoptosis induced by sublytic C5b-9 remains unclear. In this study, we demonstrate that expressions of TNFR1-associated death domain-containing protein (TRADD) and IFN regulatory factor-1 (IRF-1) were simultaneously upregulated in the renal tissue of Thy-1N rats (in vivo) and in GMCs under sublytic C5b-9 stimulation (in vitro)...
December 30, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
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