keyword
MENU ▼
Read by QxMD icon Read
search

Trypanosomiasis

keyword
https://www.readbyqxmd.com/read/28099874/igm-lgg-and-il-6-profiles-in-the-trypanosoma-brucei-brucei-monkey-model-of-human-african-trypanosomiasis
#1
Maxwell W Waema, Naomi W Maina, Maina Ngotho, Simon M Karanja, Beatrice M Gachie, Dawn N Maranga, John M Kagira
Human African trypanosomiasis (HAT) patients manifest immunological profiles, whose variations over time can be used to indicate disease progression. However, monitoring of these biomarkers in human patients is beset by several limitations which can be offset by using chronic animal models. A recent improved monkey model of HAT using a Trypanosoma brucei brucei isolate has been developed but the immunological profile has not been elucidated. The objectives of the current study was to determine the IgM, IgG and IL-6 profiles in blood and cerebrospinal fluid (CSF) in vervet monkeys infected with T...
January 15, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28087440/an-overlooked-horticultural-crop-smyrnium-olusatrum-as-a-potential-source-of-compounds-effective-against-african-trypanosomiasis
#2
Riccardo Petrelli, Farahnaz Ranjbarian, Stefano Dall'Acqua, Fabrizio Papa, Romilde Iannarelli, Stephane L Ngahang Kamte, Sauro Vittori, Giovanni Benelli, Filippo Maggi, Anders Hofer, Loredana Cappellacci
Among natural products, sesquiterpenes have shown promising inhibitory effects against bloodstream forms of Trypanosoma brucei, the protozoan parasite causing human African trypanosomiasis (HAT). Smyrnium olusatrum (Apiaceae), also known as Alexanders or wild celery, is a neglected horticultural crop characterized by oxygenated sesquiterpenes containing a furan ring. In the present work we explored the potential of its essential oils obtained from different organs and the main oxygenated sesquiterpenes, namely isofuranodiene, germacrone and β-acetoxyfuranoeudesm-4(15)-ene, as inhibitors of Trypanosoma brucei...
January 10, 2017: Parasitology International
https://www.readbyqxmd.com/read/28074881/erratum-discovery-of-a-carbazole-derived-lead-drug-for-human-african-trypanosomiasis
#3
Sarah M Thomas, Andrei Purmal, Michael Pollastri, Kojo Mensa-Wilmot
No abstract text is available yet for this article.
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28071587/new-imidazole-based-compounds-active-against-trypanosoma-cruzi
#4
Oluyomi Stephen Adeyemi, Maria Teresa Molina, Abiodun Omokehinde Eseola, Cristina Fonseca-Berzal, Alicia Gomez-Barrio
Current drugs available for the treatment of Chagas disease are fraught with several challenges including severe toxicity and limited efficacy. These factors coupled with the absence of effective drugs for treating the chronic stage of the disease have rendered the development of new drugs against Chagas disease a priority. This study screened several imidazole-based compounds for anti-Trypanosoma potential. Using in vitro experimental infection model, several imidazole-based compounds were screened for anti-proliferative effect on Trypanosoma cruzi epimastigotes...
January 10, 2017: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/28066534/chagas-disease-research-and-development-is-there-light-at-the-end-of-the-tunnel
#5
REVIEW
Eric Chatelain
Chagas disease, or American trypanosomiasis, is the result of infection by the parasite Trypanosoma cruzi. It is endemic in Latin America, and spreading around the globe due to human migration. Although it was first identified more than a century ago, only two old drugs are available for treatment and a lot of questions related to the disease progression, its pathologies, and not to mention the assessment of treatment efficacy, are subject to debate and remain to be answered. Indeed, the current status of evidence and data available does not allow any absolute statement related to treatment needs and outcome for Chagas patients to be made...
2017: Computational and Structural Biotechnology Journal
https://www.readbyqxmd.com/read/28056016/predicting-the-impact-of-intervention-strategies-for-sleeping-sickness-in-two-high-endemicity-health-zones-of-the-democratic-republic-of-congo
#6
Kat S Rock, Steve J Torr, Crispin Lumbala, Matt J Keeling
Two goals have been set for Gambian human African trypanosomiasis (HAT), the first is to achieve elimination as a public health problem in 90% of foci by 2020, and the second is to achieve zero transmission globally by 2030. It remains unclear if certain HAT hotspots could achieve elimination as a public health problem by 2020 and, of greater concern, it appears that current interventions to control HAT in these areas may not be sufficient to achieve zero transmission by 2030. A mathematical model of disease dynamics was used to assess the potential impact of changing the intervention strategy in two high-endemicity health zones of Kwilu province, Democratic Republic of Congo...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28043795/evaluation-of-substituted-ebselen-derivatives-as-potential-trypanocidal-agents
#7
Heeren M Gordhan, Stephen L Patrick, Maria I Swasy, Amber L Hackler, Mark Anayee, Jennifer E Golden, James C Morris, Daniel C Whitehead
Human African trypanosomiasis is a disease of sub-Saharan Africa, where millions are at risk for the illness. The disease, commonly referred to as African sleeping sickness, is caused by an infection by the eukaryotic pathogen, Trypanosoma brucei. Previously, a target-based high throughput screen revealed ebselen (EbSe), and its sulfur analog, EbS, to be potent in vitro inhibitors of the T. brucei hexokinase 1 (TbHK1). These molecules also exhibited potent trypanocidal activity in vivo. In this manuscript, we synthesized a series of sixteen EbSe and EbS derivatives bearing electron-withdrawing carboxylic acid and methyl ester functional groups, and evaluated the influence of these substituents on the biological efficacy of the parent scaffold...
February 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28042865/the-role-of-natural-products-in-drug-discovery-and-development-against-neglected-tropical-diseases
#8
REVIEW
Peter Mubanga Cheuka, Godfrey Mayoka, Peggoty Mutai, Kelly Chibale
Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect more than 1 billion people annually, including 875 million children in developing economies. These diseases are also responsible for over 500,000 deaths per year and are characterized by long-term disability and severe pain. The impact of the combined NTDs closely rivals that of malaria and tuberculosis. Current treatment options are associated with various limitations including widespread drug resistance, severe adverse effects, lengthy treatment duration, unfavorable toxicity profiles, and complicated drug administration procedures...
December 31, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28031550/bug-smash-bug-splash-a-case-report-of-an-unusual-transmission-of-american-trypanosomiasis-with-a-brief-review-of-the-literature
#9
Rafael Hernán Navarrete-Sandoval, Maximiliano Servín-Rojas
BACKGROUND Chagas disease is a chronic parasitosis transmitted by the inoculation of infected triatomine feces into wounds or conjunctival sac, transfusion, congenitally, organ transplantation, and ingestion of contaminated food. The disease is classified into an acute and chronic phase; the latter is a life-long infection that can be asymptomatic or progress to cardiac or digestive complications. CASE REPORT We report a case of acute-phase Chagas disease, transmitted by the splash of gut content from an infected triatomine into the conjunctival mucosa...
December 29, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/28027323/a-multi-host-agent-based-model-for-a-zoonotic-vector-borne-disease-a-case-study-on-trypanosomiasis-in-eastern-province-zambia
#10
Simon Alderton, Ewan T Macleod, Neil E Anderson, Kathrin Schaten, Joanna Kuleszo, Martin Simuunza, Susan C Welburn, Peter M Atkinson
BACKGROUND: This paper presents a new agent-based model (ABM) for investigating T. b. rhodesiense human African trypanosomiasis (rHAT) disease dynamics, produced to aid a greater understanding of disease transmission, and essential for development of appropriate mitigation strategies. METHODS: The ABM was developed to model rHAT incidence at a fine spatial scale along a 75 km transect in the Luangwa Valley, Zambia. The method offers a complementary approach to traditional compartmentalised modelling techniques, permitting incorporation of fine scale demographic data such as ethnicity, age and gender into the simulation...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28027299/past-and-ongoing-tsetse-and-animal-trypanosomiasis-control-operations-in-five-african-countries-a-systematic-review
#11
Anne Meyer, Hannah R Holt, Richard Selby, Javier Guitian
BACKGROUND: Control operations targeting Animal African Trypanosomiasis and its primary vector, the tsetse, were covering approximately 128,000 km2 of Africa in 2001, which is a mere 1.3% of the tsetse infested area. Although extensive trypanosomiasis and tsetse (T&T) control operations have been running since the beginning of the 20th century, Animal African Trypanosomiasis is still a major constraint of livestock production in sub-Saharan Africa. METHODOLOGY/PRINCIPAL FINDINGS: We performed a systematic review of the existing literature describing T&T control programmes conducted in a selection of five African countries, namely Burkina Faso, Cameroon, Ethiopia, Uganda and Zambia, between 1980 and 2015...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28013248/kynurenine-pathway-activation-in-human-african-trypanosomiasis
#12
Jeremy M Sternberg, Caroline M Forrest, R Neil Dalton, Charles Turner, Jean Rodgers, Trevor W Stone, Peter Ge Kennedy
BACKGROUND: The kynurenine pathway of tryptophan oxidation is associated with CNS inflammatory pathways. Inhibition of this pathway ameliorates CNS inflammation in rodent models of the late (meningoencephalitic) stage of Human African trypanosomiasis (HAT). In this study we evaluate whether the kynurenine pathway is activated in clinical HAT and if it is associated with CNS inflammatory responses. METHODS: We measured cerebrospinal fluid (CSF) tryptophan and kynurenine metabolite concentrations in Trypanosoma brucei rhodesiense patients using liquid chromatography-mass spectrometry...
December 24, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28011170/antiprotozoal-drug-nitazoxanide-enhances-parasitemia-tissue-lesions-and-mortality-caused-by-trypanosoma-cruzi-in-murine-model
#13
Juan Salvador Valle-Reyes, Valery Melnikov, Oxana Dobrovinskaya, Alejandrina Rodriguez-Hernández, Cristina Wookee-Zea, Víctor Pimientel-Rodrigez, Gabriela Rueda-Valdovinos, Iván Delgado-Enciso, Uriel A López-Lemus, Francisco Espinoza-Gómez
Chagas' disease is caused by unicellular parasite Trypanosoma cruzi (T. cruzi). It is endemic throughout Latin America, but nowadays has become a global challenge due to tourism and migration. Non-treated infection may result in health-threatening complications and lead to death. Current medications for this infection are nifurtimox (NFT) and benznidazol. Both drugs may cause side effects and are ineffective in the chronic phase. Therefore, new antichagasic compounds are urgently required. Nitazoxanide (NTZ) is a broad spectrum antiparasitic drug, proposed recently as a potential candidate to be added to the list of essential medicines for integrated neglected tropical disease control and elimination...
December 21, 2016: Experimental Parasitology
https://www.readbyqxmd.com/read/28011167/trypanosoma-brucei-brucei-traverses-different-biological-barriers-differently-and-may-modify-the-host-plasma-membrane-in-the-process
#14
Monica Namayanja, Yan Dai, Barbara Nerima, Enock Matovu, Zhao-Rong Lun, George W Lubega, Chen Zhengjun
Trypanosoma brucei are extracellular hemoflagellate protozoan parasites and one of the causative agents of a devastating zoonotic disease called African Trypanosomiasis. In humans, the disease is caused by Trypanosoma brucei rhodensiense and Trypanosoma brucei gambiense, which cross the blood brain barrier (BBB) causing neurological disorders which culminate in death if untreated. In some domestic animals and laboratory rodents, Trypanosoma brucei brucei causes a disease similar to that in humans. The mechanism by which Trypanosoma brucei brucei invade biological barriers including the BBB has not been fully elucidated...
December 20, 2016: Experimental Parasitology
https://www.readbyqxmd.com/read/28008825/simulating-the-elimination-of-sleeping-sickness-with-an-agent-based-model
#15
Pascal Grébaut, Killian Girardin, Valentine Fédérico, François Bousquet
Although Human African Trypanosomiasis is largely considered to be in the process of extinction today, the persistence of human and animal reservoirs, as well as the vector, necessitates a laborious elimination process. In this context, modeling could be an effective tool to evaluate the ability of different public health interventions to control the disease. Using the Cormas(®) system, we developed HATSim, an agent-based model capable of simulating the possible endemic evolutions of sleeping sickness and the ability of National Control Programs to eliminate the disease...
2016: Parasite: Journal de la Société Française de Parasitologie
https://www.readbyqxmd.com/read/28002454/trypanosoma-brucei-invasion-and-t-cell-infiltration-of-the-brain-parenchyma-in-experimental-sleeping-sickness-timing-and-correlation-with-functional-changes
#16
Claudia Laperchia, Maria Palomba, Paul F Seke Etet, Jean Rodgers, Barbara Bradley, Paul Montague, Gigliola Grassi-Zucconi, Peter G E Kennedy, Marina Bentivoglio
BACKGROUND: The timing of Trypanosoma brucei entry into the brain parenchyma to initiate the second, meningoencephalitic stage of human African trypanosomiasis or sleeping sickness is currently debated and even parasite invasion of the neuropil has been recently questioned. Furthermore, the relationship between neurological features and disease stage are unclear, despite the important diagnostic and therapeutic implications. METHODOLOGY: Using a rat model of chronic Trypanosoma brucei brucei infection we determined the timing of parasite and T-cell neuropil infiltration and its correlation with functional changes...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27992217/urea-derivatives-of-2-aryl-benzothiazol-5-amines-a-new-class-of-potential-drugs-for-human-african-trypanosomiasis
#17
Donald A Patrick, J Robert Gillespie, Joshua McQueen, Matthew A Hulverson, Ranae M Ranade, Sharon A Creason, Zackary M Herbst, Michael H Gelb, Frederick S Buckner, Richard R Tidwell
A previous publication from this lab (Patrick, et al. Bioorg. Med. Chem. 2016, 24 , 2451 - 2465 ) explored the antitrypanosomal activities of novel derivatives of 2-(2-benzamido)ethyl-4-phenylthiazole (1), which had been identified as a hit against Trypanosoma brucei, the causative agent of human African trypanosomiasis. While a number of these compounds, particularly the urea analogues, were quite potent, these molecules as a whole exhibited poor metabolic stability. The present work describes the synthesis of 65 new analogues arising from medicinal chemistry optimization at different sites on the molecule...
December 19, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27974038/african-trypanosomiasis
#18
Judy A Streit, Eiyu Matsumoto
A previously healthy 60-year-old woman presented with a 2-to-3-day history of fevers, chills, myalgias, headache, and two pruritic areas on her back. She had returned 3 days earlier from a 2-week trip to Botswana and Zimbabwe that had included canoeing and camping. She had received vaccines before..
December 15, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27941966/metabolomics-identifies-multiple-candidate-biomarkers-to-diagnose-and-stage-human-african-trypanosomiasis
#19
Isabel M Vincent, Rónán Daly, Bertrand Courtioux, Amy M Cattanach, Sylvain Biéler, Joseph M Ndung'u, Sylvie Bisser, Michael P Barrett
Treatment for human African trypanosomiasis is dependent on the species of trypanosome causing the disease and the stage of the disease (stage 1 defined by parasites being present in blood and lymphatics whilst for stage 2, parasites are found beyond the blood-brain barrier in the cerebrospinal fluid (CSF)). Currently, staging relies upon detecting the very low number of parasites or elevated white blood cell numbers in CSF. Improved staging is desirable, as is the elimination of the need for lumbar puncture...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27936225/evaluation-of-antigens-for-development-of-a-serological-test-for-human-african-trypanosomiasis
#20
Sylvain Biéler, Harald Waltenberger, Michael P Barrett, Richard McCulloch, Jeremy C Mottram, Mark Carrington, Wilhelm Schwaeble, James McKerrow, Margaret A Phillips, Paul A Michels, Philippe Büscher, Jean-Charles Sanchez, Richard Bishop, Derrick R Robinson, James Bangs, Michael Ferguson, Barbara Nerima, Audrey Albertini, Gerd Michel, Magdalena Radwandska, Joseph Mathu Ndung'u
BACKGROUND: Control and elimination of human African trypanosomiasis (HAT) can be accelerated through the use of diagnostic tests that are more accurate and easier to deploy. The goal of this work was to evaluate the immuno-reactivity of antigens and identify candidates to be considered for development of a simple serological test for the detection of Trypanosoma brucei gambiense or T. b. rhodesiense infections, ideally both. METHODOLOGY/PRINCIPAL FINDINGS: The reactivity of 35 antigens was independently evaluated by slot blot and ELISA against sera from both T...
2016: PloS One
keyword
keyword
20678
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"