keyword
MENU ▼
Read by QxMD icon Read
search

Trypanosomiasis

keyword
https://www.readbyqxmd.com/read/29780009/parasitic-diseases-that-can-infect-travelers-to-africa
#1
Muhammet Karakavuk, Mehmet Aykur, Ayşegül Ünver, Mert Döşkaya
Travel is important in the spread of diseases, and the number of travelers is increasing daily. Therefore, the importance of the diseases that occur during or after travel is increasing. In underdeveloped countries in particular, parasitic diseases are epidemic or endemic, and these diseases lead to high numbers of deaths. People traveling from developed to underdeveloped countries have a higher risk of transmission of parasitic diseases during travel. Fifteen percent of the world's population lives in Africa...
May 21, 2018: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/29779491/trypanosoma-brucei-rhodesiense-infection-in-a-chinese-traveler-returning-from-the-serengeti-national-park-in-tanzania
#2
Qin Liu, Xiao-Ling Chen, Mu-Xin Chen, Han-Guo Xie, Qing Liu, Zhu-Yun Chen, Yao-Ying Lin, Hua Zheng, Jia-Xu Chen, Yi Zhang, Xiao-Nong Zhou
BACKGROUND: Human African trypanosomiasis (HAT) is one of the most complex parasitic diseases known to humankind. It usually occurs in endemic areas in Africa, but is occasionally detected in returning travelers and migrants in non-endemic countries. CASE PRESENTATION: In August 2017, a case of HAT was diagnosed in China in a traveler returning from the Masai Mara area in Kenya and the Serengeti area in Tanzania. The traveler visited Africa from 23 July to 5 August, 2017...
May 21, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29778893/synthesis-of-proline-derived-benzenesulfonamides-a-potent-anti-trypanosoma-brucei-gambiense-agent
#3
David I Ugwu, Uchechukwu C Okoro, Narendra K Mishra
Thousands of death in Africa and other developing nations are still attributed to trypanosomiasis. Excessive sleep has been associated with increased inflammation. We report herein, the synthesis, antitrypanosomal and anti-inflammatory activities of eight new carboxamide derivatives bearing substituted benzenesulfonamides. The base promoted reactions of l-proline and L-4-hydroxyproline with substituted benzenesulfonyl chlorides gave the benzenesulfonamides (11a-h) in excellent yields. Boric acid mediated amidation of the benzenesulfonamides (11a-h) and p-aminobenzoic acid (12) gave the new carboxamides (13a-h) in excellent yields...
May 14, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29770648/-challenge-and-strategy-of-prevention-and-control-of-important-parasitic-diseases-under-the-belt-and-road-initiative
#4
Cao Chun-Li, Guo Jia-Gang
China was once a country with the heaviest burden of parasitic diseases. Under the leadership of the Communist Party and national authority, after more than 60 years' efforts of prevention and control, the remarkable results have been achieved in China. However, affected by the social and economic development and environmental changes, the prevention and control of parasitic diseases, especially imported parasitic diseases, are facing new challenges, and the parasitic diseases, such as malaria, schistosomiasis, leishmaniasis, filariasis and trypanosomiasis, appear increasingly...
April 17, 2018: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29758050/an-assessment-of-false-positive-rates-for-malaria-rapid-diagnostic-tests-caused-by-non-plasmodium-infectious-agents-and-immunological-factors
#5
Michelle L Gatton, Sadmir Ciketic, John W Barnwell, Qin Cheng, Peter L Chiodini, Sandra Incardona, David Bell, Jane Cunningham, Iveth J González
BACKGROUND: Malaria rapid diagnostic tests (RDTs) can produce false positive (FP) results in patients with human African trypanosomiasis and rheumatoid factor (RF), but specificity against other infectious agents and immunological factors is largely unknown. Low diagnostic specificity caused by cross-reactivity may lead to over-estimates of the number of malaria cases and over-use of antimalarial drugs, at the cost of not diagnosing and treating the true underlying condition. METHODS: Data from the WHO Malaria RDT Product Testing Programme was analysed to assess FP rates of 221 RDTs against four infectious agents (Chagas, dengue, Leishmaniasis and Schistosomiasis) and four immunological factors (anti-nuclear antibody, human anti-mouse antibody (HAMA), RF and rapid plasma regain)...
2018: PloS One
https://www.readbyqxmd.com/read/29758036/benzoxaborole-treatment-perturbs-s-adenosyl-l-methionine-metabolism-in-trypanosoma-brucei
#6
Pieter C Steketee, Isabel M Vincent, Fiona Achcar, Federica Giordani, Dong-Hyun Kim, Darren J Creek, Yvonne Freund, Robert Jacobs, Kevin Rattigan, David Horn, Mark C Field, Annette MacLeod, Michael P Barrett
The parasitic protozoan Trypanosoma brucei causes Human African Trypanosomiasis and Nagana in other mammals. These diseases present a major socio-economic burden to large areas of sub-Saharan Africa. Current therapies involve complex and toxic regimens, which can lead to fatal side-effects. In addition, there is emerging evidence for drug resistance. AN5568 (SCYX-7158) is a novel benzoxaborole class compound that has been selected as a lead compound for the treatment of HAT, and has demonstrated effective clearance of both early and late stage trypanosomiasis in vivo...
May 14, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29753341/human-parasitology-and-parasitic-diseases-heading-towards-2050
#7
Peter J Hotez
By 2050 our civilized planet may be comprised predominantly of networked megacities embedded in warm subtropical and tropical climates, and under stress from climate change and catastrophic weather events. Urban slum areas in these cities, including those found in wealthier middle- and high-income nations (blue marble health), will be especially vulnerable to disease. Moreover, regional conflicts fought over shifting and limited resources, including water, will collapse health systems infrastructures to further promote disease emergence and reemergence...
2018: Advances in Parasitology
https://www.readbyqxmd.com/read/29744736/compounds-from-african-medicinal-plants-with-activities-against-selected-parasitic-diseases-schistosomiasis-trypanosomiasis-and-leishmaniasis
#8
REVIEW
Conrad V Simoben, Fidele Ntie-Kang, Sergi H Akone, Wolfgang Sippl
Parasitic diseases continue to represent a threat on a global scale, particularly among the poorest countries in the world. This is particularly because of the absence of vaccines, and in some cases, resistance against available drugs, currently being used for their treatment. In this review emphasis is laid on natural products and scaffolds from African medicinal plants (AMPs) for lead drug discovery and possible further development of drugs for the treatment of parasitic diseases. In the discussion, emphasis has been laid on alkaloids, terpenoids, quinones, flavonoids and narrower compound classes of compounds with micromolar range activities against Schistosoma, Trypanosoma and Leishmania species...
May 9, 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29742443/fluorine-walk-the-impact-of-fluorine-in-quinolone-amides-on-their-activity-against-african-sleeping-sickness
#9
Michael Berninger, Christine Erk, Antje Fuß, Joseph Skaf, Ehab Al-Momani, Ina Israel, Martina Raschig, Paul Güntzel, Samuel Samnick, Ulrike Holzgrabe
Human African Trypanosomiasis, also known as African sleeping sickness, is caused by the parasitic protozoa of the genus Trypanosoma. If there is no pharmacological intervention, the parasites can cross the blood-brain barrier (BBB), inevitably leading to death of the patients. Previous investigation identified the quinolone amide GHQ168 as a promising lead compound having a nanomolar activity against T. b. brucei. Here, the role of a fluorine substitution at different positions was investigated in regard to toxicity, pharmacokinetics, and antitrypanosomal activity...
April 30, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29738470/a-3d-qsar-study-on-the-antitrypanosomal-and-cytotoxic-activities-of-steroid-alkaloids-by-comparative-molecular-field-analysis
#10
Charles Okeke Nnadi, Julia Barbara Althaus, Ngozi Justina Nwodo, Thomas Jürgen Schmidt
As part of our research for new leads against human African trypanosomiasis (HAT), we report on a 3D-QSAR study for antitrypanosomal activity and cytotoxicity of aminosteroid-type alkaloids recently isolated from the African medicinal plant Holarrhena africana A. DC. (Apocynaceae), some of which are strong trypanocides against Trypanosoma brucei rhodesiense ( Tbr ), with low toxicity against mammalian cells. Fully optimized 3D molecular models of seventeen congeneric Holarrhena alkaloids were subjected to a comparative molecular field analysis (CoMFA)...
May 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29733118/in-vitro-antiprotozoan-activity-and-mechanisms-of-action-of-selected-ghanaian-medicinal-plants-against-trypanosoma-leishmania-and-plasmodium-parasites
#11
Mitsuko Ohashi, Michael Amoa-Bosompem, Kofi Dadzie Kwofie, Jefferey Agyapong, Richard Adegle, Maxwell Mamfe Sakyiamah, Frederick Ayertey, Kofi Baffuor-Awuah Owusu, Isaac Tuffour, Philip Atchoglo, Nguyen Huu Tung, Takuhiro Uto, Frederick Aboagye, Alfred Ampomah Appiah, Regina Appiah-Opong, Alexander K Nyarko, William Kofi Anyan, Irene Ayi, Daniel Adjei Boakye, Kwadwo Ansah Koram, Dominic Edoh, Shoji Yamaoka, Yukihiro Shoyama, Nobuo Ohta
Trypanosomiasis, leishmaniasis, and malaria are protozoan infections of public health importance with thousands of new cases recorded annually. Control of these infection(s) with existing chemotherapy is limited by drug toxicity, lengthy parenteral treatment, affordability, and/or the emergence of resistant strains. Medicinal plants on the other hand are used in the treatment of various infectious diseases although their chemical properties are not fully evaluated. In this study, we screened 112 crude extracts from 72 selected Ghanaian medicinal plants for anti-Trypanosoma, anti-Leishmania, and anti-Plasmodium activities in vitro and investigated their mechanisms of action...
May 7, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29720251/a-meta-analysis-of-the-prevalence-of-african-animal-trypanosomiasis-in-nigeria-from-1960-to-2017
#12
REVIEW
Paul Olalekan Odeniran, Isaiah Oluwafemi Ademola
BACKGROUND: African animal trypanosomiasis is an economically significant disease that affects the livestock industry in Nigeria. It is caused by several parasites of the genus Trypanosoma. National estimates of the disease prevalence in livestock and tsetse flies are lacking, therefore a systematic review and meta-analysis were performed to understand the trend of the disease prevalence over the years. METHODS: Publications were screened in Web of Science, Ovid MEDLINE, Global Health, EMBASE and PubMed databases...
May 2, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29715287/multisectoral-prioritization-of-zoonotic-diseases-in-uganda-2017-a-one-health-perspective
#13
Musa Sekamatte, Vikram Krishnasamy, Lilian Bulage, Christine Kihembo, Noelina Nantima, Fred Monje, Deo Ndumu, Juliet Sentumbwe, Betty Mbolanyi, Robert Aruho, Winyi Kaboyo, David Mutonga, Colin Basler, Sarah Paige, Casey Barton Behravesh
BACKGROUND: Zoonotic diseases continue to be a public health burden globally. Uganda is especially vulnerable due to its location, biodiversity, and population. Given these concerns, the Ugandan government in collaboration with the Global Health Security Agenda conducted a One Health Zoonotic Disease Prioritization Workshop to identify zoonotic diseases of greatest national concern to the Ugandan government. MATERIALS AND METHODS: The One Health Zoonotic Disease Prioritization tool, a semi-quantitative tool developed by the U...
2018: PloS One
https://www.readbyqxmd.com/read/29705579/melarsoprol-resistance-in-african-trypanosomiasis
#14
REVIEW
Alan H Fairlamb, David Horn
Arsenicals were introduced as monotherapies for the treatment of human African trypanosomiasis, or sleeping sickness, over 100 years ago. Toxicity has always been an issue but these drugs have proven to be both effective and quite durable. Unfortunately, melarsoprol-resistant parasites emerged as early as the 1970s and were widespread by the late 1990s. Resistance was due to mutations affecting an aquaglyceroporin (AQP2), a parasite solute and drug transporter. This is the only example of widespread drug resistance in trypanosomiasis patients for which the genetic basis is known...
April 25, 2018: Trends in Parasitology
https://www.readbyqxmd.com/read/29703229/impact-of-an-integrated-control-campaign-on-tsetse-populations-in-burkina-faso
#15
Lassané Percoma, Adama Sow, Soumaïla Pagabeleguem, Ahmadou H Dicko, Oumarou Serdebéogo, Mariam Ouédraogo, Jean-Baptiste Rayaissé, Jérémy Bouyer, Adrien M G Belem, Issa Sidibé
BACKGROUND: Tsetse flies are the sole vectors of human and animal trypanosomosis. In Burkina Faso, a project aiming to create zones free of tsetse flies and trypanosomosis was executed from June 2006 to December 2013. After the determination of tsetse distribution in the intervention area from December 2007 to November 2008, the control campaign was launched in November 2009 and ended in December 2013. The goal was to eliminate tsetse flies from 40,000 km2 of area, through an integrated control campaign including insecticide targets, traps and cattle, sequential aerial treatment (SAT) and the mass treatment of livestock using trypanocides...
April 27, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29703146/identification-of-a-novel-fused-gene-family-implicates-convergent-evolution-in-eukaryotic-calcium-signaling
#16
Fei Chen, Liangsheng Zhang, Zhenguo Lin, Zong-Ming Max Cheng
BACKGROUND: Both calcium signals and protein phosphorylation responses are universal signals in eukaryotic cell signaling. Currently three pathways have been characterized in different eukaryotes converting the Ca2+ signals to the protein phosphorylation responses. All these pathways have based mostly on studies in plants and animals. RESULTS: Based on the exploration of genomes and transcriptomes from all the six eukaryotic supergroups, we report here in Metakinetoplastina protists a novel gene family...
April 27, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29701144/current-and-future-prospects-of-nitro-compounds-as-drugs-for-trypanosomiasis-and-leishmaniasis
#17
Alan H Fairlamb, Stephen Patterson
Interest in nitroheterocyclic drugs for the treatment of infectious diseases has undergone a resurgence in recent years. Here we review the current status of monocyclic and bicyclic nitroheterocyclic compounds as existing or potential new treatments for visceral leishmaniasis, Chagas' disease and human African trypanosomiasis. Both monocyclic (nifurtimox, benznidazole and fexinidazole) and bicyclic (pretomanid (PA-824) and delamanid (OPC-67683)) nitro-compounds are prodrugs, requiring enzymatic activation to exert their parasite toxicity...
April 26, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29701141/structure-based-virtual-screening-and-biochemical-evaluation-for-the-identification-of-novel-trypanosoma-brucei-aldolase-inhibitors
#18
Leonardo L G Ferreira, Rafaela S Ferreira, David L Palomino, Adriano D Andricopulo
The glycolytic enzyme fructose-1,6-bisphosphate aldolase is a validated molecular target in human African trypanosomiasis (HAT) drug discovery, a neglected tropical disease (NTD) caused by the protozoan Trypanosoma brucei. Herein, a structure-based virtual screening (SBVS) approach to the identification of novel T. brucei aldolase inhibitors is described. Distinct molecular docking algorithms were used to screen more than 500,000 compounds against the X-ray structure of the enzyme. This SBVS strategy led to the selection of a series of molecules which were evaluated for their activity on recombinant T...
April 27, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29695139/comparative-analysis-of-repetitive-dna-between-the-main-vectors-of-chagas-disease-triatoma-infestans-and-rhodnius-prolixus
#19
Sebastián Pita, Pablo Mora, Jesús Vela, Teresa Palomeque, Antonio Sánchez, Francisco Panzera, Pedro Lorite
Chagas disease or American trypanosomiasis affects six to seven million people worldwide, mostly in Latin America. This disease is transmitted by hematophagous insects known as "kissing bugs" (Hemiptera, Triatominae), with Triatoma infestans and Rhodnius prolixus being the two most important vector species. Despite the fact that both species present the same diploid chromosome number (2 n = 22), they have remarkable differences in their total DNA content, chromosome structure and genome organization...
April 24, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29690511/anti-parasitic-activities-of-allium-sativum-and-allium-cepa-against-trypanosoma-b-brucei-and-leishmania-tarentolae
#20
Sonja Krstin, Mansour Sobeh, Markus Santhosh Braun, Michael Wink
Background: Garlics and onions have been used for the treatment of diseases caused by parasites and microbes since ancient times. Trypanosomiasis and leishmaniasis are a concern in many areas of the world, especially in poor countries. Methods: Trypanosoma brucei brucei and Leishmania tarentolae were used to investigate the anti-parasitic effects of dichloromethane extracts of Allium sativum (garlic) and Allium cepa (onion) bulbs. As a confirmation of known antimicrobial activities, they were studied against a selection of G-negative, G-positive bacteria and two fungi...
April 21, 2018: Medicines (Basel, Switzerland)
keyword
keyword
20678
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"