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https://www.readbyqxmd.com/read/29230816/how-grinding-levels-and-brewing-methods-espresso-american-turkish-could-affect-the-antioxidant-activity-and-bioactive-compounds-in-a-coffee-cup
#1
Antonio Derossi, Ilde Ricci, Rossella Caporizzi, Anna Fiore, Carla Severini
BACKGROUND: Depending on geographical origins and cultural traditions, different brewing procedures are used all over the world to prepare a coffee cup. In this work, we explored as three grinding levels of coffee powder and three coffee preparation methods such as by filtration (American), by boiling (Turkish) and by extraction under pressure (Espresso) affect healthy compounds and physicochemical attributes in coffee cup served to consumers. RESULTS: the grinding level slightly affects the quality of coffees, while the preparation methods significantly influenced all in-cup attributes...
December 11, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29230349/reinforcing-value-of-caffeinated-and-noncaffeinated-beverages-after-acute-exposure-in-children-and-adolescents
#2
Jennifer L Temple, Amanda M Ziegler, Adam M Graczyk, Amanda K Crandall
Background: When caffeine is added to beverages, it increases beverage liking and the relative reinforcing value (RRV) of these beverages after repeated exposure. The purpose of this study was to test the hypothesis that a single acute exposure to caffeine increases liking and motivation to consume sugar-sweetened beverages (SSBs) relative to placebo. Methods: Participants were children ages 8-9 years (n = 36) and adolescents ages 15-17 years (n = 41) with an approximately equal number of boys and girls...
December 1, 2017: Journal of Caffeine Research
https://www.readbyqxmd.com/read/29230348/a-randomized-two-way-crossover-study-to-evaluate-the-pharmacokinetics-of-caffeine-delivered-using-caffeinated-chewing-gum-versus-a-marketed-caffeinated-beverage-in-healthy-adult-volunteers
#3
Paul Sadek, Xiao Pan, Phil Shepherd, Elise Malandain, John Carney, Hugh Coleman
Background: This study was conducted to compare the pharmacokinetics of caffeine delivered using caffeinated chewing gum to that delivered using a marketed caffeinated beverage (instant coffee) in 16 healthy adult volunteers. Materials and Methods: This was a controlled open-label, randomized, two-period crossover study. Caffeinated chewing gum and a serving of instant coffee, each containing ∼50 mg caffeine, were administered with blood samples collected before and up to 24 hours after administration starts...
December 1, 2017: Journal of Caffeine Research
https://www.readbyqxmd.com/read/29229227/the-importance-of-the-circadian-system-sleep-for-bone-health
#4
Christine M Swanson, Wendy M Kohrt, Orfeu M Buxton, Carol A Everson, Kenneth P Wright, Eric S Orwoll, Steven A Shea
Adequate sleep timed appropriately during the circadian night is important for numerous biological processes and systems. New evidence suggests that both sleep timing and duration may be important for optimal bone health as well. This review examines the diurnal variation of bone turnover markers (BTMs) and the importance of circadian clock genes in regulating bone mass. In addition, this review explores the evidence for a link between shift work (and its associated disturbances in sleep duration/quality and circadian alignment) and alterations in bone metabolism and bone health...
December 8, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29228755/long-term-supplementation-of-decaffeinated-green-tea-extract-does-not-modify-body-weight-or-abdominal-obesity-in-a-randomized-trial-of-men-at-high-risk-for-prostate-cancer
#5
Nagi B Kumar, Roshni Patel, Julio Pow-Sang, Philippe E Spiess, Raoul Salup, Christopher R Williams, Michael J Schell
Background: Evidence continues to demonstrate the role of obesity in prostate carcinogenesis and prognosis, underscoring the need to identify and continue to evaluate the effective interventions to reduce obesity in populations at high risk. The aim of the study was to determine the effect of daily consumption of decaffeinated green tea catechins (GTC) formulation (Polyphenon E® (PolyE)) for 1 year on biomarkers of obesity in men who are at high risk for prostate cancer. Materials and Methods: A randomized, double-blinded trial was conducted targeting 97 men diagnosed with HGPIN or ASAP...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29227957/synergistic-cytotoxicity-and-mechanism-of-caffeine-and-lysozyme-on-hepatoma-cell-line-hepg2
#6
Hongchao Yang, Jingjuan Li, Lin Cui, Yanqing Ren, Liying Niu, Xinguo Wang, Yun Huang, Lijian Cui
The influences of caffeine, lysozyme and the joint application of them on the hepatoma cell line HepG2 proliferation inhibition and cell apoptosis were observed by 3-(4, 5-dimethyl-2-thiazyl)-2, 5-diphenyl-2H-tetrazolium bromide assay and Hoechst 33342, which showed the proliferation inhibition rate of the joint application on HepG2 cells was 47.21%, significantly higher than caffeine or lysozyme, and the joint application promoted the apoptosis of HepG2 cells obviously. Van't Hoff classical thermodynamics formula, the Föster theory of non-radiation energy transfer and fluorescence phase diagram were used to manifest that the process of lysozyme binding to caffeine followed a two-state model, which was spontaneous at low temperature driven by enthalpy change, and the predominant intermolecular force was hydrogen bonding or Van der Waals force to stabilize caffeine-lysozyme complex with the distance 5...
December 6, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29225735/effects-of-energy-drinks-on-the-cardiovascular-system
#7
REVIEW
Bishoy Wassef, Michelle Kohansieh, Amgad N Makaryus
Throughout the last decade, the use of energy drinks has been increasingly looked upon with caution as potentially dangerous due to their perceived strong concentration of caffeine aside from other substances such as taurine, guarana, and L-carnitine that are largely unknown to the general public. In addition, a large number of energy drink intoxications have been reported all over the world including cases of seizures and arrhythmias. In this paper, we focus on the effect of energy drinks on the cardiovascular system and whether the current ongoing call for the products' sales and regulation of their contents should continue...
November 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/29225318/caffeine-stimulated-intestinal-epithelial-cells-suppress-lipid-accumulation-in-adipocytes
#8
Takakazu Mitani, Tomoya Nagano, Kiyonari Harada, Yoko Yamashita, Hitoshi Ashida
Caffeine is a methylxanthine derived from plant foods such as coffee beans and tea leaves, and has multiple biological activities against physiological response and several diseases. Although there are some reports about the direct effect of caffeine against anti-lipid accumulation in vitro, the effect of caffeine on lipid accumulation in adipocytes through stimulating intestinal epithelial cells is unknown. Since direct treatment with caffeine to 3T3-L1 cells did not affect lipid accumulation, we determined whether caffeine-stimulated intestinal epithelial Caco-2 cells influence the lipid accumulation in 3T3-L1 adipocytes...
2017: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/29224920/-cognitive-doping-in-students-a-chim-er-ical-way-to-get-full-head
#9
Louise Carton, Nicolas Cabé, Olivier Ménard, Sylvie Deheul, Anne-Sylvie Caous, David Devos, Olivier Cottencin, Régis Bordet
For students, the requirements for memorization, increased performance and peer competition may encourage cognitive doping behaviors. We aimed to describe recent practices and the benefit/risk ratio of such behavior to discuss the different issues. The prevalence of cognitive doping among students was 1.3% to 33% according to the studies, depending on the country concerned and the definition of cognitive doping used. The therapeutic classes most frequently cited as being diverted were psychostimulants and nootropics (methylphenidate, modafinil, piracetam), corticosteroids, sedative drugs and beta-blockers...
November 22, 2017: Thérapie
https://www.readbyqxmd.com/read/29223552/caffeine-rich-infusion-from-cola-nitida-kola-nut-inhibits-major-carbohydrate-catabolic-enzymes-abates-redox-imbalance-and-modulates-oxidative-dysregulated-metabolic-pathways-and-metabolites-in-fe2-induced-hepatic-toxicity
#10
Ochuko L Erukainure, Olajumoke A Oyebode, Mxolisi K Sokhela, Neil A Koorbanally, Md Shahidul Islam
The antioxidative and antidiabetic effects and toxicity of caffeine-rich infusion of Cola nitida were investigated using in vitro, ex vivo and in silico models. C. nitida was infused in boiling water and allowed to cool before concentrating at <50°C. HPLC analysis of the infusion revealed a caffeine content of 80.08%. The infusion showed potent in vitro antioxidant activity by significantly (p<0.05) scavenging 2,2'-diphenyl-1-picrylhydrazyl (DPPH). It significantly (p<0.05) inhibited α-glucosidase and α-amylase activities...
December 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29223460/investigation-of-anticancer-properties-of-caffeinated-complexes-via-computational-chemistry-methods
#11
Koray Sayin, Ayhan Üngördü
Computational investigations were performed for 1,3,7-trimethylpurine-2,6-dione, 3,7-dimethylpurine-2,6-dione, their Ru(II) and Os(III) complexes. B3LYP/6-311++G(d,p)(LANL2DZ) level was used in numerical calculations. Geometric parameters, IR spectrum, 1H-, 13C and 15N NMR spectrum were examined in detail. Additionally, contour diagram of frontier molecular orbitals (FMOs), molecular electrostatic potential (MEP) maps, MEP contour and some quantum chemical descriptors were used in the determination of reactivity rankings and active sites...
December 6, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29215606/cognitive-and-mood-effects-of-a-nutrient-enriched-breakfast-bar-in-healthy-adults-a-randomised-double-blind-placebo-controlled-parallel-groups-study
#12
David O Kennedy, Emma L Wightman, Joanne Forster, Julie Khan, Crystal F Haskell-Ramsay, Philippa A Jackson
OBJECTIVES: Few previous studies have assessed the effects of concomitant administration of multiple potentially psychoactive nutrients. METHODS: 95 healthy adult participants consumed either a nutrient enriched breakfast bar (containing α-Linolenic acid, l-tyrosine, l-theanine, vitamins, minerals and 21.5 mg of caffeine) or an isocaloric, macronutrient matched control bar for 56 days. Cognitive function and mood were assessed pre-dose and at 40- and 160-min post-dose on the 1st and 56th day of the intervention period...
December 7, 2017: Nutrients
https://www.readbyqxmd.com/read/29215336/caffeine-increases-apolipoprotein-a-1-and-paraoxonase-1-but-not-paraoxonase-3-protein-levels-in-human-derived-liver-hepg2-cells
#13
Gülben Sayılan Özgün, Eray Özgün, Kıymet Tabakçıoğlu, Selma Süer Gökmen, Sevgi Eskiocak, Erol Çakır
BACKGROUND: Apolipoprotein A-1, paraoxonase-1 and paraoxonase-3 are antioxidant and anti-atherosclerotic structural high-density lipoprotein proteins that are mainly synthesized by the liver. No study has ever been performed to specifically examine the effects of caffeine on paraoxonase enzymes and on liver apolipoprotein A-1 protein levels. AIMS: To investigate the dose-dependent effects of caffeine on liver apolipoprotein A-1, paraoxonase-1 and paraoxonase-3 protein levels...
December 1, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/29214920/caffeine-effects-on-vo2max-test-outcomes-investigated-by-a-placebo-perceived-as-caffeine-design
#14
Cayque Brietzke, Ricardo Yukio Asano, Felipe De Russi de Lima, Fabiano Aparecido Pinheiro, Franco-Alvarenga, Carlos Ugrinowitsch, Flávio Oliveira Pires
BACKGROUND: Ergogenic effects of caffeine (CAF) ingestion have been observed in different cycling exercise modes, and have been associated with alterations in ratings of perceived exertion (RPE). However, there has been little investigation of maximal oxygen uptake (VO2MAX) test outcomes. AIM: This study aimed to verify whether CAF may reduce RPE, thereby improving maximal incremental test (MIT) outcomes such as VO2MAX, time to exhaustion and peak power output (WPEAK)...
December 2017: Nutrition and Health
https://www.readbyqxmd.com/read/29212769/functional-and-structural-characterization-of-a-novel-malignant-hyperthermia-susceptible-variant-of-dhpr-%C3%AE-1a-subunit-cacnb1
#15
Claudio F Perez, Jose M Eltit, Jose R Lopez, Dóra Bodnár, Angela F Dulhunty, Shouvik Aditya, Marco G Casarotto
Malignant Hyperthermia (MH) susceptibility has been recently linked to a novel variant of β1a subunit of the dihydropyridine receptor (DHPR), a channel essential for Ca2+ regulation in skeletal muscle. Here we evaluate the effect of the mutant variant V156A on the structure/function of DHPR β1a subunit and assess its role on Ca2+ metabolism of cultured myotubes. Using differential scanning fluorimetry we show that mutation V156A causes a significant reduction in thermal stability of the Src homology 3 (SH3)/Guanylate Kinase (GK) core domain of β1a subunit...
December 6, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29211339/%C3%AE-3-adrenoceptor-agonists-inhibit-carbachol-evoked-ca2-oscillations-in-murine-detrusor-myocytes
#16
Caoimhin S Griffin, Eamonn Bradley, Mark A Hollywood, Noel G McHale, Keith D Thornbury, Gerard P Sergeant
OBJECTIVE: To test if carbachol-evoked Ca2+ oscillations in freshly isolated murine detrusor myocytes were affected by β3-adrenoceptor modulators. MATERIAL & METHODS: Isometric tension recordings were made from strips of murine detrusor and intracellular Ca2+ measurements were made from isolated detrusor myocytes using confocal microscopy. Transcriptional expression of β-AR sub-types in detrusor strips and isolated detrusor myocytes was assessed using RT-PCR and real-time quantitative PCR...
December 6, 2017: BJU International
https://www.readbyqxmd.com/read/29210957/the-physiological-and-performance-effects-of-caffeine-gum-consumed-during-a-simulated-half-time-by-professional-academy-rugby-union-players
#17
Russell M, Reynolds N A, Crewther B T, Cook C J, Kilduff L
Despite the prevalence of caffeine as an ergogenic aid, few studies have examined the use of caffeinated gums, especially during half-time in team sports. The physiological (blood lactate, salivary hormone concentrations) and performance (repeated sprints, cognitive function) effects of consuming caffeine gum during a simulated half-time were examined. Professional academy rugby union players (n=14) completed this double-blind, randomized, counterbalanced study. Following pre-exercise measurements , players chewed a placebo (PL) gum for five min before a standardized warm-up and completing repeated sprint testing (RSSA1)...
November 27, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29209861/development-of-new-analytical-methods-for-the-determination-of-caffeine-content-in-aqueous-solution-of-green-coffee-beans
#18
Blen Weldegebreal, Mesfin Redi-Abshiro, Bhagwan Singh Chandravanshi
BACKGROUND: This study was conducted to develop fast and cost effective methods for the determination of caffeine in green coffee beans. In the present work direct determination of caffeine in aqueous solution of green coffee bean was performed using FT-IR-ATR and fluorescence spectrophotometry. Caffeine was also directly determined in dimethylformamide solution using NIR spectroscopy with univariate calibration technique. RESULTS: The percentage of caffeine for the same sample of green coffee beans was determined using the three newly developed methods...
December 5, 2017: Chemistry Central Journal
https://www.readbyqxmd.com/read/29209802/-doping-for-the-brain
#19
REVIEW
Bernhard Iglseder
The enhancement of physical and cognitive abilities (i. e. concentration, vigilance, memory) has always been desirable for humans. The term pharmacological neuroenhancement refers to the use of legal or nonprescription psychoactive substances by healthy subjects with the intention of cognitive enhancement. To give the most prominent example, caffeine serves worldwide as a natural stimulant. Brain doping, however, specifies the use of illegal substances or prescription drugs beyond approval with the purpose of cognitive enhancement...
December 5, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29209411/dietary-behaviour-psychological-well-being-and-mental-distress-among-adolescents-in-korea
#20
Seo Ah Hong, Karl Peltzer
Background: Dietary intake is important for physical and mental health. The aim of this investigation was to assess associations between dietary behaviours and psychological well-being and distress among school-going adolescents in Korea. Methods: In a cross-sectional nationally representative survey, 65,212 students (Mean age = 15.1 years, SE = 0.02 and 52.2% male and 47.8% female) responded to a questionnaire that included measures of dietary behaviour, psychological well-being and mental distress...
2017: Child and Adolescent Psychiatry and Mental Health
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