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Tooraj Amini, Payman Hashemi
A simple, fast and green homogeneous liquid-liquid microextraction (HLLME) method based on solvents volume ratio alteration (SVRA) combined with gas chromatography-mass spectrometry (GC-MS) was developed for the preconcentration and determination of caffeine in tea and coffee samples. In the proposed HLLME-SVRA method, the primary extraction from solid samples was achieved by a 2:1 ethanol-water mixture. A micro-volume of dichloromethane (DCM) formed a homogeneous solvent with this mixture after choosing an appropriate volume ratio between the three solvents...
June 12, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Dawn E Anderson, Sarah E LeGrand, Reece D McCart
Anderson, DE, LeGrand, SE, and McCart, RD. Effect of caffeine on sprint cycling in experienced cyclists. J Strength Cond Res XX(X): 000-000, 2018-Research regarding the ergogenic effects of caffeine (CAF) in anaerobic activity remains inconclusive. However, some researchers have found significant improvements in anaerobic performance when testing specifically trained athletes. A double-blind, placebo-controlled, counterbalanced, cross-over design was implemented to assess the impact of CAF on a 30-second Wingate Anaerobic Test (WAnT) in experienced cyclists...
June 15, 2018: Journal of Strength and Conditioning Research
Daniel P Hsu, Shana L Hansen, Timothy A Roberts, Clinton K Murray, Vincent Mysliwiec
Introduction: In 2013, the U.S. Army Surgeon General implemented the Performance Triad (P3), an educational initiative to improve health-related behaviors of soldiers throughout the U.S. Army. The components of P3 are Sleep, Activity, and Nutrition with tenet behaviors for each component. This study reports the results of the 2015 U.S. Army Medical Corps survey regarding physician knowledge and adherence to the tenet behaviors of P3. Methods: In 2015, an anonymous survey was sent to all active duty U...
April 18, 2018: Military Medicine
Valentin Joubert, Virginie Silvestre, Mathilde Grand, Denis Loquet, Virginie Ladroue, Fabrice Besacier, Serge Akoka, Gerald Stanislas Remaud
For the last ten years, quantitative isotope ratio monitoring 13C NMR (irm-13C NMR) has been successfully tested and proved as an efficient tool for the determination of the position-specific determination of 13C/12C ratios. Several applications in different domains have shown its interest. In the context of origin assignment, the possibility to track the distribution network of illicit drugs or cutting agents is of prime importance. However irm-13C NMR still suffers from a relative lack of sensitivity limiting its dissemination among control laboratories...
June 18, 2018: Analytical Chemistry
Laura López-Cruz, John D Salamone, Mercè Correa
Major depressive disorder is one of the most common and debilitating psychiatric disorders. Some of the motivational symptoms of depression, such anergia (lack of self-reported energy) and fatigue are relatively resistant to traditional treatments such as serotonin uptake inhibitors. Thus, new pharmacological targets are being investigated. Epidemiological data suggest that caffeine consumption can have an impact on aspects of depressive symptomatology. Caffeine is a non-selective adenosine antagonist for A1 /A2A receptors, and has been demonstrated to modulate behavior in classical animal models of depression...
2018: Frontiers in Pharmacology
Maria Willadsen, Laura M Best, Markus Wöhr, Paul B S Clarke
RATIONALE: Adult rat 22-kHz vocalizations are often associated with alarm or distress, whereas a subset of 50-kHz calls is preferentially emitted in response to amphetamine and other rewarding stimuli. Whether any 50-kHz calls reflect anxiety is unknown. OBJECTIVE: To determine the effects of anxiogenic drugs on 50-kHz call rate and call subtype profile, in comparison with D-amphetamine. METHODS: Adult male rats received systemic amphetamine (1 mg/kg) three times several days before testing...
June 16, 2018: Psychopharmacology
Amira M Soliman, Ahmed M Fathalla, Ahmed A Moustafa
Although adenosine plays a key role in multiple motor, affective, and cognitive processes, it has received less attention in the neuroscience field compared to other neurotransmitters (e.g., dopamine). In this review, we highlight the role of adenosine in behavior as well as its interaction with other neurotransmitters, such as dopamine. We also discuss brain disorders impacted by alterations to adenosine, and how targeting adenosine can ameliorate Parkinson's disease motor symptoms. We also discuss the role of caffeine (as an adenosine antagonist) on cognition as well as a neuroprotective agent against Parkinson's disease (PD)...
February 3, 2018: Pharmacological Reports: PR
Amanda Maria Sena Reis, Karina Pessoa Oliveira, Isabela Helena Fagundes de Paula, Alisson Paulo da Silva, Júlia Fahrion Tarragô, Natália de Melo Ocarino, Rogéria Serakides
OBJECTIVE: Evaluate the effects of doses of caffeine administered to pregnant rats on the articular cartilage chondrocytes of their offspring. METHODS: Twenty-four adult Wistar rats were randomly assigned to four groups, with one control group and three groups being treated with caffeine at doses of 25, 50 and 100 mg/kg throughout pregnancy. At birth, three offspring/females were euthanized so that the chondrocytes could be extracted. At 7, 14 and 21 days of culture, the chondrocytes were subjected to the MTT cell viability assay and an evaluation of their alkaline phosphatase activity and collagen synthesis...
June 12, 2018: Acta Histochemica
Jong Hyun Jhee, Ki Heon Nam, Seong Yeong An, Min-Uk Cha, Misol Lee, Seohyun Park, Hyoungnae Kim, Hae-Ryong Yun, Youn Kyung Kee, Jung Tak Park, Tae-Ik Chang, Ea Wha Kang, Tae-Hyun Yoo, Shin-Wook Kang, Seung Hyeok Han
BACKGROUND: Drinking coffee can raise public health problems, but the association between coffee and kidney disease is unknown. We studied whether coffee intake can affect the development of chronic kidney disease in the general population. METHODS: We analyzed 8717 subjects with normal renal function recruited from the KoGES cohort. Based on food frequency questionnaire, coffee consumption was categorized into five groups: 0/week, <1 cup/week, 1-6 cups/week, 1 cup/day, and ≥2 cups/day...
June 12, 2018: American Journal of Medicine
Ruochun Zhang, Tan Meng, Ching-Hua Huang, Weiwei Ben, Hong Yao, Ruini Liu, Peizhe Sun
The combination of chlorine and UV (i.e. chlorine-UV process) has been attracting more attentions in recent years due to its ready incorporation into existing water treatment facilities to remove PPCPs. However, limited information is available on the impact of total ammonia nitrogen (TAN). This study investigated two model PPCPs, N,N-diethyl-3-toluamide (DEET) and caffeine (CAF), in the two stages of chlorine-UV process (i.e. chlorination and UV/chlor(am)ine) to elucidate the impact of TAN. During chlorination, the degradation of DEET and CAF was positively correlated with the overall consumption of total chlorine by TAN...
June 15, 2018: Environmental Science & Technology
Lydia Herzel, Korinna Straube, Karla M Neugebauer
Pre-mRNA splicing is accomplished by the spliceosome, a megadalton complex that assembles de novo on each intron. Because spliceosome assembly and catalysis occur cotranscriptionally, we hypothesized that introns are removed in the order of their transcription in genomes dominated by constitutive splicing. Remarkably little is known about splicing order and the regulatory potential of nascent transcript remodeling by splicing, due to the limitations of existing methods that focus on analysis of mature splicing products (mRNAs) rather than substrates and intermediates...
June 14, 2018: Genome Research
Bernhard Durner, Thomas Ehmann, Frank-Michael Matysik
The adaption of an parallel-path poly(tetrafluoroethylene)(PTFE) ICP-nebulizer to an evaporative light scattering detector (ELSD) was realized. This was done by substituting the originally installed concentric glass nebulizer of the ELSD. The performance of both nebulizers was compared regarding nebulizer temperature, evaporator temperature, flow rate of nebulizing gas and flow rate of mobile phase of different solvents using caffeine and poly(dimethylsiloxane) (PDMS) as analytes. Both nebulizers showed similar performances but for the parallel-path PTFE nebulizer the performance was considerably better at low LC flow rates and the nebulizer lifetime was substantially increased...
June 5, 2018: Journal of Chromatography. A
Hua Yin
OBJECTIVE: To establish a high performance liquid chromatographytandem mass spectrometry( HPLC-MS/MS) method for simultaneous determination of caffeine, benzoic acid, sorbic acid, acesulfame potassium, saccharin sodium and sodium cyclamate in drink. METHODS: The sample was extracted by ASPEC using extraction column( Pro Elut C_(18)500 mg/6 m L), dried by Turbo VapⅡ and dissolved in mobile phase. The supernatant was separated on Agilent SB-C_(18) column( 2. 1 mm × 50 mm, 1...
November 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
Sarva Mangala Praveena, Siti Norashikin Mohamad Shaifuddin, Syazwani Sukiman, Fauzan Adzima Mohd Nasir, Zanjabila Hanafi, Norizah Kamarudin, Tengku Hanidza Tengku Ismail, Ahmad Zaharin Aris
This study investigated the occurrence of nine pharmaceuticals (amoxicillin, caffeine, chloramphenicol, ciprofloxacin, dexamethasone, diclofenac, nitrofurazone, sulfamethoxazole, and triclosan) and to evaluate potential risks (human health and ecotoxicological) in Lui, Gombak and Selangor (Malaysia) rivers using commercial competitive Enzyme-Linked Immunosorbent Assay (ELISA) kit assays. Physicochemical properties of these rivers showed the surface samples belong to Class II of Malaysian National Water Quality Standards which requires conventional treatment before consumption...
June 11, 2018: Science of the Total Environment
Cong Xu, Lei Chen, Luhua You, Zheng Xu, Long-Fei Ren, Karina Yew-Hoong Gin, Yiliang He, Weizhi Kai
PPCPs and pesticides have been documented throughout the world over the years, yet relatively little is known about the factors affecting their spatial distribution and temporal change in order to know their potential risk to the ecosystem or human health in the future. In our study, 5 PPCPs and 9 pesticides were selected to study their occurrence, impact variables and potential risk in a drinking water reservoir in Yangtze Estuary and related drinking water treatment plants (DWTPs) in China. The detection results showed the presence of PPCPs and pesticides reflected in a large part of croplands and urban and built-up land in the adjacent basin...
June 14, 2018: Environmental Science. Processes & Impacts
Ram B Jain, Alan Ducatman
Cross-sectional data from National Health and Nutrition Examination Survey for the years 1999-2012 for those aged ≥20 years, fasting for at least 8 h, and classified as smokers and nonsmokers on the basis of observed serum cotinine levels were used to evaluate the impact of smoking on the adjusted and unadjusted concentrations of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, total cholesterol (TC), and triglycerides (TG). Adjustments were made for the effects of gender; race/ethnicity; survey year; dietary intake of alcohol; caffeine; cholesterol; saturated, unsaturated, and total fatty acids; fasting time; body mass index; and poverty income ratio...
January 2018: Journal of Circulating Biomarkers
Lin Ma, Yifei Liu, Jing Zhang, Qing Yang, Guanghe Li, Dayi Zhang
Groundwater pollution by emerging contaminants, such as pharmaceutical and personal care products (PPCPs), has caused increasing concerns around the world. The vadose zone is an active zone where lithosphere, hydrosphere and biosphere interact. It is an important medium for PPCPs removal and entry into groundwater from irrigation using wastewater or polluted surface water. In the present study, the occurrence and distribution of eleven PPCPs in areas with a vadose zone (up to 16 m) was investigated from wastewater irrigated farmland, groundwater irrigated farmland and a seasonal river course in Beijing (China)...
June 1, 2018: Science of the Total Environment
Hyoun S Kim, Briana D Cassetta, David C Hodgins, Daniel S McGrath, Lianne M Tomfohr-Madsen, Hermano Tavares
OBJECTIVE: While it has been shown that disordered gamblers with psychosis are at increased risk for comorbid psychopathology, it is unclear whether this dual-diagnosis population is also at greater risk of problematic engagement with comorbid addictive behaviors. METHODS: We tested for association between disordered gambling with psychosis and comorbid addictive behaviors in a sample of 349 treatment-seeking disordered gamblers. RESULTS: Twenty-five (7...
June 11, 2018: Revista Brasileira de Psiquiatria
Reem Al Marshad, Razan Al Khatib, Hanine Amer, Munirah Al Shammari, Aysha Al Otaibi, Fahad Al Otaibi, Nadiah Behbehani, Anwaar Al Sayed, Norah Al Hoty, Zuheir Hassan, Amer Kamal
Objective: To investigate the deterioration of the brain functions by diabetes mellitus (DM) and the beneficial effect of caffeine. Materials and Methods: First, the component of N-methyl-D-aspartate receptors (NMDA) of the field excitatory postsynaptic potential (fEPSP) were recorded in streptozotocin (STZ)-induced DM and compared with control animals. Later, 40 mice were divided randomly into five groups (8 mice in each): (1) Normal control (Cont), (2) diabetic group (DM), (3) animals pretreated with i...
May 2018: International Journal of Health Sciences
Heba Shaaban, Ahmed Mostafa
Background: Green analytical chemistry (GAC) aims to eliminate or minimize the amount ofhazardous solvents consumed and generated daily worldwide. Considering the environmental impact of all analytical procedures and replacing the polluting methodologies with clean ones is of a paramount interest. Objective: This work aims to develop and validate a sustainable, fast, and economic ultrahigh-performance liquid chromatography method for simultaneous determination of methylxanthines in commercial tea samples as well as to evaluate the greenness profile of the proposed method using two greenness assessment tools: National Environmental Methods Index (NEMI) and analytical Eco-scale...
June 12, 2018: Journal of AOAC International
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