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https://www.readbyqxmd.com/read/28213471/attenuation-of-endoplasmic-reticulum-stress-by-caffeine-ameliorates-hyperoxia-induced-lung-injury
#1
Ru-Jeng Teng, Xigang Jing, Teresa Michalkiewicz, Adeleye J Afolayan, Tzong-Jin Wu, Girija G Konduri
Rodent pups exposed to hyperoxia develop lung changes similar to bronchopulmonary dysplasia (BPD) in extremely premature infants. Oxidative stress from hyperoxia can injure developing lungs through endoplasmic reticulum (ER) stress. Early caffeine treatment decreases the rate of BPD, but the mechanisms remain unclear. We hypothesized that caffeine attenuates hyperoxia-induced lung injury through its chemical chaperone property. Sprague-Dawley rat pups were raised either in 90% (hyperoxia) or 21% (normoxia) oxygen from postnatal day 1 (P1) to postnatal day 10 (P10) and then recovered in 21% oxygen until P21...
February 17, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28213294/a-low-cost-simplified-and-scaleable-pneumotachograph-and-face-mask-for-neonatal-mouse-respiratory-measurements
#2
Jenny J Sun, Roshan Nanu, Russell S Ray
INTRODUCTION: Neonatal respiratory disorders are a leading cause of perinatal mortality due to complications resulting from premature births and prenatal exposure to drugs of abuse, but optimal treatments for these symptoms are still unclear due to a variety of confounds and risk factors. Mouse models present an opportunity to study the underlying mechanisms and efficacy of potential treatments of these conditions with controlled variables. However, measuring respiration in newborn mice is difficult and commercial components are expensive and often require modification, creating a barrier and limiting our understanding of the short and long-term effects of birth complications on respiratory function...
February 14, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/28213242/cocaine-profiling-implementation-of-a-predictive-model-by-atr-ftir-coupled-with-chemometrics-in-forensic-chemistry
#3
Stefano Materazzi, Adolfo Gregori, Luigi Ripani, Azzurra Apriceno, Roberta Risoluti
In this study, a strategy based on Infrared Spectroscopy with Fourier Transformed and Attenuated Total Reflectance associated with chemometrics (ATR-FTIR) is proposed to identify the chemical "fingerprint" of cocaine samples. To this end, standard mixtures of cocaine and cuttings at differents ratio were investigated in order to develop a multivariate classification model to simultaneously predict the composition of the samples and to obtain a profile of adulteration of cocaine seizures. In addition, the application of a Partial Least Squares (PLS) and Principal Component Regression (PCR) calibration approaches were found to be a useful tool to predict the content of cocaine, caffeine, procaine, lidocaine and phenacetin in drug seizures...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28212875/genotyping-by-sequencing-provides-the-first-well-resolved-phylogeny-for-coffee-coffea-and-insights-into-the-evolution-of-caffeine-content-in-its-species-gbs-coffee-phylogeny-and-the-evolution-of-caffeine-content
#4
Perla Hamon, Corrinne E Grover, Aaron P Davis, Jean-Jacques Rakotomalala, Nathalie E Raharimalala, Victor A Albert, Hosahalli L Sreenath, Piet Stoffelen, Sharon E Mitchell, Emmanuel Couturon, Serge Hamon, Alexandre de Kochko, Dominique Crouzillat, Michel Rigoreau, Ucu Sumirat, Sélastique Akaffou, Romain Guyot
A comprehensive and meaningful phylogenetic hypothesis for the commercially important coffee genus (Coffea) has long been a key objective for coffee researchers. For molecular studies, progress has been limited by low levels of sequence divergence, leading to insufficient topological resolution and statistical support in phylogenetic trees, particularly for the major lineages and for the numerous species occurring in Madagascar. We report here the first almost fully resolved, broadly sampled phylogenetic hypothesis for coffee, the result of combining genotyping-by-sequencing (GBS) technology with a newly developed, lab-based workflow to integrate short read next-generation sequencing for low numbers of additional samples...
February 14, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28211649/insufficient-sleep-in-adolescents-causes-and-consequences
#5
Judith A Owens, Miriam R Weiss
Insufficient sleep poses an important and complicated set of health risks in the adolescent population. Not only is deficient sleep (defined as both sleep duration inadequate to meet sleep needs and sleep timing misaligned with the body's circadian rhythms) at epidemic levels in this population, but the contributing factors are both complex and numerous and there are a myriad of negative physical and mental health, safety and performance consequences. Causes of inadequate sleep identified in this population include internal biological processes such as the normal shift (delay) in circadian rhythm that occurs in association with puberty and a developmentally-based slowing of the "sleep drive", and external factors including extracurricular activities, excessive homework load, evening use of electronic media, caffeine intake and early school start times...
February 17, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28207926/alcohol-mixed-with-energy-drinks-daily-context-of-use
#6
Ashley N Linden-Carmichael, Cathy Lau-Barraco
The link between use of alcohol mixed with energy drinks (AmEDs) and alcohol-related harms is well established, but limited research has examined the context in which AmEDs are consumed. Identifying the social and environmental characteristics of use may illuminate whether AmEDs are used in settings that could increase the likelihood of engaging in risky behaviors or experiencing harms. The present study used a two-week daily diary assessment to compare days in which AmEDs were consumed ("AmED days") and days where other types of alcohol were used ("non-AmED days") on where, when, and with whom drinking occurred METHODS: Participants were 122 (90 women) heavy drinking college students who reported mixing caffeine with alcohol at least once in the past week...
February 16, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28206974/caffeine-delays-oocyte-aging-and-maintains-the-quality-of-aged-oocytes-safely-in-mouse
#7
Xia Zhang, Xiaoyan Liu, Li Chen, Dan-Ya Wu, Zheng-Wen Nie, Ying-Ying Gao, Yi-Liang Miao
Caffeine, as an oocyte aging inhibitor, was used in many different species to control or delay oocyte aging. However, the safety of caffeine and developmental competence of aged oocytes inhibited by caffeine has not been studied systematically. So we detected the spindle morphology, distribution of cortical granules, zona pellucida hardening and pronucleus formation to assess oocyte quality of caffeine treated oocytes. We found that aged oocytes treated by caffeine maintained weak susceptibility to activating stimuli and regained normal competent after aged further 6 hr...
February 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28203771/a-rapid-uplc-method-for-simultaneous-analysis-of-caffeine-and-13-index-polyphenols-in-black-tea
#8
Hai-Bo Pan, Dan Zhang, Bo Li, Yuan-Yuan Wu, You-Ying Tu
No abstract text is available yet for this article.
February 14, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28202385/long-term-consequences-of-disrupting-adenosine-signaling-during-embryonic-development
#9
REVIEW
Scott A Rivkees, Christopher C Wendler
There is growing evidence that disruption in the prenatal environment can have long-lasting effects on an individual's health in adulthood. Research on the fetal programming of adult diseases, including cardiovascular disease, focuses on epi-mutations, which alter the normal pattern of epigenetic factors such as DNA methylation, miRNA expression, or chromatin modification, rather than traditional genetic alteration. Thus, understanding how in utero chemical exposures alter epigenetics and lead to adult disease is of considerable public health concern...
February 12, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/28198658/effects-of-acute-and-chronic-caffeine-on-risk-taking-behavior-in-children-and-adolescents
#10
Jennifer L Temple, Amanda M Ziegler, Adam M Graczyk, Amanda Crandall
Consumption of caffeinated beverages is associated with increased risk-taking behavior. The purpose of this study was to determine if acute caffeine administration influences risk-taking behavior in a dose-dependent manner. Participants were pre- (ages 8-9) and post-pubertal (ages 15-17) children who visited the laboratory three times and consumed a beverage containing 0, 1, or 2 mg/kg of caffeine. Thirty minutes later, participants completed the balloon analogue risk task (BART), the Iowa gambling task (IGT), and a delay discounting task...
February 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28198465/fatigue-related-impairments-in-oculomotor-control-are-prevented-by-norepinephrine-dopamine-reuptake-inhibition
#11
Charlotte J W Connell, Benjamin Thompson, Jason Turuwhenua, Alexa Srzich, Nicholas Gant
Fatigue-induced reductions in saccade velocity have been reported following acute, prolonged exercise. Interestingly, the detrimental impact of fatigue on oculomotor control can be prevented by a moderate dose of caffeine. This effect may be related to central catecholamine upregulation via caffeine's action as an adenosine antagonist. To test this hypothesis, we compared the protective effect of caffeine on oculomotor control post-exercise to that of a norepinephrine-dopamine reuptake inhibitor. Within a placebo-controlled crossover design, 12 cyclists consumed placebo, caffeine or a norepinephrine-dopamine reuptake inhibitor (bupropion) during 180 minutes of stationary cycling...
February 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28196026/caffeine-inhibits-fluid-secretion-by-interlobular-ducts-from-guinea-pig-pancreas
#12
Yuka Mochimaru, Akiko Yamamoto, Miyuki Nakakuki, Makoto Yamaguchi, Ituka Taniguchi, Hiroshi Ishiguro
OBJECTIVES: Caffeine is contained in coffee, tea, and a lot of beverages and foods. We examined the direct effects of caffeine on the physiological function of pancreatic duct cells by using interlobular duct segments isolated from guinea pig pancreas. METHODS: The rate of fluid secretion was continuously measured by monitoring the luminal volume of isolated duct segments. Changes in intracellular Ca concentration ([Ca]i) were estimated by microfluorometry in ducts loaded with fura-2...
February 14, 2017: Pancreas
https://www.readbyqxmd.com/read/28194561/xanthine-alkaloids-occurrence-biosynthesis-and-function-in-plants
#13
Hiroshi Ashihara, Kouichi Mizuno, Takao Yokota, Alan Crozier
Caffeine is a xanthine alkaloid found in non-alcoholic beverages such as tea, coffee, and cocoa. It was discovered in tea and coffee in the 1820s, but it was not until 2000 that details of molecular events associated with caffeine biosynthesis began to be unraveled. Reviewed are the occurrence of xanthine alkaloids in the plant kingdom and the elucidation of the caffeine biosynthesis pathway, providing details of the N-methyltransferases, belonging to the motif B' methyltransferase family, which catalyze three steps in the four-step pathway leading from xanthosine to caffeine...
2017: Progress in the Chemistry of Organic Natural Products
https://www.readbyqxmd.com/read/28192967/direct-analysis-of-xanthine-stimulants-in-archaeological-vessels-by-laser-desorption-resonance-enhanced-multiphoton-ionization
#14
Shawn C Owens, Jacob A Berenbeim, Marshall R Ligare, Lisa E Gulian, Faady M Siouri, Samuel Boldissar, Stuart Tyson-Smith, Gregory Wilson, Anabel Ford, Mattanjah S de Vries
Resonance enhanced multiphoton ionization spectroscopy (REMPI) generates simultaneous vibronic spectroscopy and fragment free mass spectrometry to identify molecules within a complex matrix. We combined laser desorption with REMPI spectroscopy to study organic residues within pottery sherds from Maya vessels (600-900 CE) and Mississippian vessels (1100-1200 CE), successfully detecting three molecular markers, caffeine, theobromine, and theophylline, associated with the use of cacao. This analytical approach provides a high molecular specificity, based on both wavelength and mass identification...
February 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28192609/effect-of-vitamin-d3-fortification-and-saskatoon-berry-syrup-addition-on-the-flavor-profile-acceptability-and-antioxidant-properties-of-rooibos-tea-aspalathus-linearis
#15
Jennifer Grant, Donna Ryland, Cara K Isaak, Suvira Prashar, Yaw L Siow, Carla G Taylor, Michel Aliani
The unique characteristics and healthful reputation of caffeine-free rooibos tea (RT) make it an ideal carrier for vitamin D3 supplementation, and a potential base for the addition of Saskatoon berry syrup (SBS), a natural flavor additive. The objective of this study was to determine the effect of vitamin D3 fortification and SBS addition on the flavor profile, consumer acceptability, and antioxidant properties of RT. Six formulations (RT, RT with SBS, RT with SBS and vitamin D3 , RT with vitamin D3 , green tea [GT], and GT with SBS) were evaluated by 12 trained panelists and 114 consumers...
February 13, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28190575/water-quality-variables-and-pollution-sources-shaping-stream-macroinvertebrate-communities
#16
Elisabeth Berger, Peter Haase, Mathias Kuemmerlen, Moritz Leps, Ralf Bernhard Schäfer, Andrea Sundermann
In 2015, over 90 percent of German rivers failed to reach a good ecological status as demanded by the EU Water Framework Directive (WFD). Deficits in water quality, mainly from diffuse pollution such as agricultural run-off, but also from wastewater treatment plants (WWTPs), have been suggested as important drivers of this decline in ecological quality. We modelled six macroinvertebrate based metrics indicating ecological quality for 184 streams in response to a) PCA-derived water quality gradients, b) individual water quality variables and c) catchment land use and wastewater exposure indices as pollution drivers...
February 9, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28188930/microrna-135a-regulates-sodium-calcium-exchanger-gene-expression-and-cardiac-electrical-activity
#17
Eric Duong, Jiening Xiao, Xiao Yan Qi, Stanley Nattel
BACKGROUND: Complete atrioventricular block (CAVB) causes arrhythmogenic remodeling and increases the risk of Torsades de Pointes (TdP) arrhythmias. MicroRNAs (miRNAs) are key regulators of gene-expression that contribute to cardiac remodeling. OBJECTIVE: To assess miRNA changes after complete atrioventricular block (CAVB) and identify novel candidates potentially involved in arrhythmogenic cardiac remodeling. METHODS: CAVB was induced in mice via His bundle ablation...
February 7, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28187518/male-caffeine-and-alcohol-intake-in-relation-to-semen-parameters-and-in%C3%A2-vitro-fertilization-outcomes-among-fertility-patients
#18
A E Karmon, T L Toth, Y-H Chiu, A J Gaskins, C Tanrikut, D L Wright, R Hauser, J E Chavarro
Much of the literature on the impact of male caffeine and alcohol intake on reproductive outcomes has utilized semen quality as a proxy for male fertility, although semen parameters have a limited predictive value for spontaneous pregnancy. The objective of this study was to investigate whether male caffeine and alcohol intakes are associated with semen parameters and assisted reproductive technology outcome. The Environment and Reproductive Health Study, an ongoing prospective cohort study, enrolls subfertile couples presenting for treatment at an academic fertility center (2007-2012)...
February 10, 2017: Andrology
https://www.readbyqxmd.com/read/28182503/do-glucose-and-caffeine-nasal-sprays-influence-exercise-and-or-cognitive-performance
#19
Kevin De Pauw, Bart Roelands, Jeroen Van Cutsem, Lieselot Decroix, Angelica Valente, Kim Taehee, Robert B LettanII, Andres E Carrillo, Romain Meeusen
INTRODUCTION/PURPOSE: Since nasal sprays (NAS) containing caffeine (CAF) or glucose (GLUC) activate sensory(motor) cortices, the aim of this study was to investigate the influence of CAF or GLUC-NAS on exercise and cognitive performance. METHODS: Eleven male subjects (Age: 22±2 yrs) performed a maximal cycle test, two familiarization and three experimental trials. Each trial included a 30 s Wingate test and a 30 min time-trial (TT) performance test interspersed by 15 min of rest...
February 9, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28179084/corrigendum-to-influence-of-caffeine-on-the-protective-activity-of-gabapentin-and-topiramate-in-a-mouse-model-of-generalized-tonic-clonic-seizures-pharmacol-rep-68-2016-680-685
#20
Małgorzata Jargiełło-Baszak, Magdalena Chrościńska-Krawczyk, Marta Andres-Mach, Jarogniew J Łuszczki, Stanisław J Czuczwar
No abstract text is available yet for this article.
February 5, 2017: Pharmacological Reports: PR
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