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https://www.readbyqxmd.com/read/27906050/the-sh3-and-cysteine-rich-domain-3-stac3-gene-is-important-to-growth-fiber-composition-and-calcium-release-from-the-sarcoplasmic-reticulum-in-postnatal-skeletal-muscle
#1
Xiaofei Cong, Jonathan Doering, Davi A G Mazala, Eva R Chin, Robert W Grange, Honglin Jiang
BACKGROUND: The SH3 and cysteine-rich domain 3 (Stac3) gene is specifically expressed in the skeletal muscle. Stac3 knockout mice die perinatally. In this study, we determined the potential role of Stac3 in postnatal skeletal muscle growth, fiber composition, and contraction by generating conditional Stac3 knockout mice. METHODS: We disrupted the Stac3 gene in 4-week-old male mice using the Flp-FRT and tamoxifen-inducible Cre-loxP systems. RESULTS: RT-qPCR and western blotting analyses of the limb muscles of target mice indicated that nearly all Stac3 mRNA and more than 70 % of STAC3 protein were deleted 4 weeks after tamoxifen injection...
April 11, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27902644/coffee-consumption-and-risk-of-nonmelanoma-skin-cancer-a-dose-response-meta-analysis
#2
Golnaz Vaseghi, Shaghayegh Haghjoo-Javanmard, Jamal Naderi, Azadeh Eshraghi, Manijeh Mahdavi, Marjan Mansourian
Several epidemiological studies have evaluated the associations between coffee consumption and the risk of skin cancer; however, the results were not conclusive. This systematic review and meta-analysis of the cohort and case-control studies was carried out to determine the association between coffee intake and the risk of nonmelanoma skin cancer. Studies were identified by searching the PubMed and MEDLINE databases (to November 2015). Study-specific risk estimates were pooled under the random-effects model...
November 29, 2016: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/27899304/caffeine-for-apnea-of-prematurity-effects-on-the-developing-brain
#3
REVIEW
Anzari Atik, Richard Harding, Robert De Matteo, Delphi Kondos-Devcic, Jeanie Cheong, Lex W Doyle, Mary Tolcos
Caffeine is a methylxanthine that is widely used to treat apnea of prematurity (AOP). In preterm infants, caffeine reduces the duration of respiratory support, improves survival rates and lowers the incidence of cerebral palsy and cognitive delay. There is, however, little evidence relating to the immediate and long-term effects of caffeine on brain development, especially at the cellular and molecular levels. Experimental data are conflicting, with studies showing that caffeine can have either adverse or benefical effects in the developing brain...
November 26, 2016: Neurotoxicology
https://www.readbyqxmd.com/read/27898032/the-antiproliferative-effect-of-chakasaponins-i-and-ii-floratheasaponin-a-and-epigallocatechin-3-o-gallate-isolated-from-camellia-sinensis-on-human-digestive-tract-carcinoma-cell-lines
#4
Niichiro Kitagawa, Toshio Morikawa, Chiaki Motai, Kiyofumi Ninomiya, Shuhei Okugawa, Ayaka Nishida, Masayuki Yoshikawa, Osamu Muraoka
Acylated oleanane-type triterpene saponins, namely chakasaponins I (1) and II (2), floratheasaponin A (3), and their analogs, together with catechins-including (-)-epigallocatechin 3-O-gallate (4), flavonoids, and caffeine-have been isolated as characteristic functional constituents from the extracts of "tea flower", the flower buds of Camellia sinensis (Theaceae), which have common components with that of the leaf part. These isolates exhibited antiproliferative activities against human digestive tract carcinoma HSC-2, HSC-4, MKN-45, and Caco-2 cells...
November 26, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27895607/caffeine-enhances-memory-performance-in-young-adults-during-their-non-optimal-time-of-day
#5
Stephanie M Sherman, Timothy P Buckley, Elsa Baena, Lee Ryan
Many college students struggle to perform well on exams in the early morning. Although students drink caffeinated beverages to feel more awake, it is unclear whether these actually improve performance. After consuming coffee (caffeinated or decaffeinated), college-age adults completed implicit and explicit memory tasks in the early morning and late afternoon (Experiment 1). During the morning, participants ingesting caffeine demonstrated a striking improvement in explicit memory, but not implicit memory. Caffeine did not alter memory performance in the afternoon...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27894020/the-anatomical-mummies-of-mombello-detection-of-cocaine-nicotine-and-caffeine-in-the-hair-of-psychiatric-patients-of-the-early-20th-century
#6
Frank Musshoff, Helena Fels, Alberto Carli, Dario Piombino-Mascali
The Mombello Psychiatric Hospital in Limbiate, near Milan, replaced the old Senavra Hospital as the Psychiatric Hospital for the Province of Milan in the 19th century. During the early 20th century, bodies of several Mombello patients were dissected and preserved by Giuseppe Paravicini, an anatomist who operated within the asylum. The aim of the present study was to examine and memorialize this important assemblage. To this end, we were allowed to sample the head hair of six such preparations for toxicological analysis...
November 14, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27891166/relation-of-24-hour-urinary-caffeine-and-caffeine-metabolite-excretions-with-self-reported-consumption-of-coffee-and-other-caffeinated-beverages-in-the-general-population
#7
Dusan Petrovic, Sandrine Estoppey Younes, Menno Pruijm, Belén Ponte, Daniel Ackermann, Georg Ehret, Nicolas Ansermot, Markus Mohaupt, Fred Paccaud, Bruno Vogt, Antoinette Pechère-Bertschi, Pierre-Yves Martin, Michel Burnier, Chin B Eap, Murielle Bochud, Idris Guessous
BACKGROUND: Caffeine intake is generally estimated by self-reported consumption, but it remains unclear how well self-report associates with metabolite urinary excretion. We investigated the associations of self-reported consumption of caffeinated drinks with urinary excretion of caffeine and its major metabolites in an adult population. METHODS: We used data from the population-based Swiss Kidney Project on Genes in Hypertension (SKIPOGH) study. Consumption of caffeinated coffee, decaffeinated coffee and other caffeinated beverages was assessed by self-administered questionnaire...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27890589/aged-mice-receiving-caffeine-since-adulthood-show-distinct-patterns-of-anxiety-related-behavior
#8
Paulo Henrique S Botton, Daniela Pochmann, Andreia S Rocha, Fernanda Nunes, Amanda S Almeida, Daniela M Marques, Lisiane O Porciúncula
Caffeine is the psychostimulant most consumed worldwide. Anxiogenic effects of caffeine have been described in adult animalswith controversial findings about its anxiogenic potential. Besides, the effects of caffeine on anxiety with aging are still poorly known. In this study, adult mice (6months old) started to receive caffeine (0.3 and 1.0mg/mL, drinking water) during 12-14months only in the light cycle and at weekdays. The open field (OF) and elevated plus maze (EPM) testing were used to determine the effects of caffeine on anxiety-related behavior in adult and aged mice (18-20months old)...
November 24, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27889114/the-hidden-web-and-the-fentanyl-problem-detection-of-ocfentanil-as-an-adulterant-in-heroin
#9
Pol Quintana, Mireia Ventura, Marc Grifell, Alvaro Palma, Liliana Galindo, Iván Fornís, Cristina Gil, Xoán Carbón, Fernando Caudevilla, Magí Farré, Marta Torrens
BACKGROUND: The popularization of anonymous markets such as Silk Road is challenging current drug policy and may provide a new context for old issues, such as adulteration of heroin with fentanyl derivatives. The aims of this paper are to report the presence of ocfentanil, a novel, potent, non-controlled fentanyl analog, in samples sold as heroin in the hidden web, and to summarize the effects reported by users. METHODS: In 2015, four samples allegedly bought as heroin in cryptomarkets of the hidden web were sent to Energy Control for analysis...
November 23, 2016: International Journal on Drug Policy
https://www.readbyqxmd.com/read/27882605/placebo-in-sports-nutrition-a-proof-of-principle-study-involving-caffeine-supplementation
#10
B Saunders, L F de Oliveira, R P da Silva, V de Salles Painelli, L S Gonçalves, G Yamaguchi, T Mutti, E Maciel, H Roschel, G G Artioli, B Gualano
We investigated the effects of supplement identification on exercise performance with caffeine supplementation. Forty-two trained cyclists (age 37 ± 8 years, body mass [BM] 74.3 ± 8.4 kg, height 1.76 ± 0.06 m, maximum oxygen uptake 50.0 ± 6.8 mL/kg/min) performed a ~30 min cycling time-trial 1 h following either 6 mg/kgBM caffeine (CAF) or placebo (PLA) supplementation and one control (CON) session without supplementation. Participants identified which supplement they believed they had ingested ("caffeine", "placebo", "don't know") pre- and post-exercise...
November 23, 2016: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/27881620/catching-fakes-new-markers-of-urine-sample-validity-and-invalidity
#11
Melissa M Goggin, Cheng-Min Tann, Anna Miller, An Nguyen, Gregory C Janis
Urine drug testing is common for workplace drug testing, prescription management, emergency medicine and the criminal justice system. Unsurprisingly, with the significant consequences based upon the results of urine drug testing, a donor in need of concealing the contents of their sample is highly motivated to cheat the process. Procedures and safeguards ensuring sample validity are well known, and include measuring sample temperature at the time of collection, and laboratory measurements of creatinine, specific gravity and pH...
November 22, 2016: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/27881593/dairy-food-intake-is-associated-with-reproductive-hormones-and-sporadic-anovulation-among-healthy-premenopausal-women
#12
Keewan Kim, Jean Wactawski-Wende, Kara A Michels, Torie C Plowden, Ellen N Chaljub, Lindsey A Sjaarda, Sunni L Mumford
BACKGROUND: Dairy food intake has been associated with infertility; however, little is known with regard to associations with reproductive hormones or anovulation. OBJECTIVE: We investigated whether intakes of dairy foods and specific nutrients were associated with reproductive hormone concentrations across the cycle and the risk of sporadic anovulation among healthy women. METHODS: We prospectively measured serum reproductive hormones ≤8 times/menstrual cycle for 2 cycles from 259 regularly menstruating women (mean age: 27...
November 23, 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27880832/chronic-low-calorie-sweetener-use-and-risk-of-abdominal-obesity-among-older-adults-a-cohort-study
#13
Chee W Chia, Michelle Shardell, Toshiko Tanaka, David D Liu, Kristofer S Gravenstein, Eleanor M Simonsick, Josephine M Egan, Luigi Ferrucci
INTRODUCTION: Low-calorie sweetener use for weight control has come under increasing scrutiny as obesity, especially abdominal obesity, remain entrenched despite substantial low-calorie sweetener use. We evaluated whether chronic low-calorie sweetener use is a risk factor for abdominal obesity. PARTICIPANTS AND METHODS: We used 8268 anthropometric measurements and 3096 food diary records with detailed information on low-calorie sweetener consumption in all food products, from 1454 participants (741 men, 713 women) in the Baltimore Longitudinal Study of Aging collected from 1984 to 2012 with median follow-up of 10 years (range: 0-28 years)...
2016: PloS One
https://www.readbyqxmd.com/read/27875567/transforming-water-social-influence-moderates-psychological-physiological-and-functional-response-to-a-placebo-product
#14
Alia J Crum, Damon J Phillips, J Parker Goyer, Modupe Akinola, E Tory Higgins
This paper investigates how social influence can alter physiological, psychological, and functional responses to a placebo product and how such responses influence the ultimate endorsement of the product. Participants consumed a product, "AquaCharge Energy Water," falsely-labeled as containing 200 mg of caffeine but which was actually plain spring water, in one of three conditions: a no social influence condition, a disconfirming social influence condition, and a confirming social influence condition. Results demonstrated that the effect of the product labeling on physiological alertness (systolic blood pressure), psychological alertness (self-reported alertness), functional alertness (cognitive interference), and product endorsement was moderated by social influence: participants experienced more subjective, physiological and functional alertness and stronger product endorsement when they consumed the product in the confirming social influence condition than when they consumed the product in the disconfirming social influence condition...
2016: PloS One
https://www.readbyqxmd.com/read/27867643/high-salt-diet-and-caffeine-food-for-thought
#15
COMMENT
Alexander Staruschenko, Daria V Ilatovskaya, Tengis S Pavlov
No abstract text is available yet for this article.
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27867329/caffeine-as-a-probable-factor-for-increased-risk-of-oab-development-in-elderly-people
#16
Kirill V Kosilov, Sergay A Loparev, Marina A Ivanovskaya, Liliya V Kosilova
OBJECTIVE: This study was conducted to compare overactive bladder (OAB) prevalence among people greater than 60 years of age who intake various doses of caffeine, as well as those who abstain from caffeine. PATIENTS AND METHODS: A randomized observational study was carried out in Vladivostok Gerontological Hospital. A total of 1,098 retired people greater than 60 years of age (659 women and 439 men, average age 67.1 years) took part in the study. They were admitted to the in-patient department with the purpose of annual physical examination performed in accordance with the order of the Ministry of Public Health of the Russian Federation...
October 2016: Current Urology
https://www.readbyqxmd.com/read/27867214/immersive-virtual-reality-in-computational-chemistry-applications-to-the-analysis-of-qm-and-mm-data
#17
Andrea Salvadori, Gianluca Del Frate, Marco Pagliai, Giordano Mancini, Vincenzo Barone
The role of Virtual Reality (VR) tools in molecular sciences is analyzed in this contribution through the presentation of the Caffeine software to the quantum chemistry community. Caffeine, developed at Scuola Normale Superiore, is specifically tailored for molecular representation and data visualization with VR systems, such as VR theaters and helmets. Usefulness and advantages that can be gained by exploiting VR are here reported, considering few examples specifically selected to illustrate different level of theory and molecular representation...
November 15, 2016: International Journal of Quantum Chemistry
https://www.readbyqxmd.com/read/27866274/ryanodine-receptor-type-3-does-not-contribute-to-contractions-in-the-mouse-myometrium-regardless-of-pregnancy
#18
Katsuhito Matsuki, Masashi Takemoto, Yoshiaki Suzuki, Hisao Yamamura, Susumu Ohya, Hiroshi Takeshima, Yuji Imaizumi
Ryanodine receptor type 3 (RyR3) is expressed in myometrial smooth muscle cells (MSMCs). The short isoform of RyR3 is a dominant negative variant (DN-RyR3) and negatively regulates the functions of RyR2 and full-length (FL)-RyR3. DN-RyR3 has been suggested to function as a major RyR3 isoform in non-pregnant (NP) mouse MSMCs, and FL-RyR3 may also be upregulated during pregnancy (P). This increase in the FL-RyR3/DN-RyR3 ratio may contribute to the strong contractions by MSMCs for parturition. In the present study, spontaneous contractions by the myometrium in NP and P mice were highly susceptible to nifedipine but were not affected by ryanodine...
November 20, 2016: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/27865772/kissing-bugs-can-generalize-and-discriminate-between-different-bitter-compounds
#19
Yamila Asparch, Gina Pontes, Santiago Masagué, Sebastian Minoli, Romina B Barrozo
Animals make use of contact chemoreception structures to examine the quality of potential food sources. During this evaluation they can detect nutritious compounds that promote feeding and recognize toxins that trigger evasive behaviors. Although animals can easily distinguish between stimuli of different gustatory qualities (bitter, salty, sweet, etc.), their ability to discriminate between compounds of the same quality may be limited. Numerous plants produce alkaloids, compounds that elicit aversive behaviors in phytophagous insects and almost uniformly evoke a bitter taste for man...
November 16, 2016: Journal of Physiology, Paris
https://www.readbyqxmd.com/read/27864843/measurement-of-caffeine-and-its-three-primary-metabolites-in-human-plasma-by-hplc-esi-ms-ms-and-clinical-application
#20
Feng Chen, Zhe-Yi Hu, Robert B Parker, S Casey Laizure
Caffeine is a mild stimulant with significant potential for abuse being consumed in larger doses with the widespread availability of energy drinks and by novel routes of administration such as inspired powder, oral sprays, and electronic cigarettes. How these recent changes in caffeine consumption affecting caffeine disposition and abuse potential is of growing concern. In the study of caffeine disposition in humans, it is common to only measure the caffeine concentration; however, caffeine's three major metabolites (paraxanthine, theobromine, and theophylline) retain central nervous system stimulant activity that may contribute to the overall pharmacological activity and toxicity...
November 18, 2016: Biomedical Chromatography: BMC
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