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https://www.readbyqxmd.com/read/28922543/in-vitro-and-in-vivo-degradation-of-microfiber-bioresorbable-coronary-scaffold
#1
Chi-Hung Huang, Sheng-Yang Lee, Sonida Horng, Louis-Georges Guy, Ting-Bin Yu
The degradation of Mirage Bioresorbable Microfiber Scaffold was evaluated in vitro and in vivo. The degradation in polymer molecular weight (MW), strut morphology, and integrity was accessed using gel permeation chromatography (GPC), X-ray micro-computed tomography (micro-CT) evaluation. To simulate the physiological degradation in vitro, scaffolds were deployed in silicone mock vessels connected to a peristaltic pumping system, which pumps 37°C phosphate-buffered saline (PBS, pH 7.4) at a constant rate. At various time points (30D, 60D, 90D, 180D, 270D, and 360D), the MW of microfibers decreased to 57...
September 18, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28917393/reduction-in-depressive-symptoms-in-primary-prevention-icd-scheduled-patients-one-year-prospective-study
#2
Revital Amiaz, Elad Asher, Guy Rozen, Efrat Czerniak, Linda Levi, Mark Weiser, Michael Glikson
OBJECTIVE: Implantable Cardioverter Defibrillators (ICDs), have previously been associated with the onset of depression and anxiety. The aim of this one-year prospective study was to evaluate the rate of new onset psychopathological symptoms after elective ICD implantation. METHODS: A total of 158 consecutive outpatients who were scheduled for an elective ICD implantation were diagnosed and screened based on the Mini International Neuropsychiatric Interview (MINI)...
September 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28914397/influence-of-acid-treatment-on-surface-properties-and-in-vivo-performance-of-ti6al4v-alloy-for-biomedical-applications
#3
Daniel J Fernandes, Ruy G Marques, Carlos N Elias
The purpose of this work was to investigate the influence of acid treatment on the surface properties and in vivo performance of titanium grade 5 (Ti6Al4V) alloy. Mini-implants with surface treatment were inserted into New Zealand rabbit tibia for 1, 4 and 8 weeks. SEM analysis showed intercommunicated micropores in acid treated samples. AFM showed micron and sub-micron roughness. The thickness of the titanium oxide layer increased with surface treatment, with a significant reduction of Al and V concentration...
September 15, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28869535/mitochondrial-targeted-antioxidant-maintains-blood-flow-mitochondrial-function-and-redox-balance-in-old-mice-following-prolonged-limb-ischemia
#4
Shunsuke Miura, Shu-Ichi Saitoh, Tomoki Kokubun, Takashi Owada, Hiroyuki Yamauchi, Hirofumi Machii, Yasuchika Takeishi
Aging is a major factor in the decline of limb blood flow with ischemia. However, the underlying mechanism remains unclear. We investigated the role of mitochondrial reactive oxygen species (ROS) with regard to limb perfusion recovery in aging during ischemia. We performed femoral artery ligation in young and old mice with or without treatment with a scavenger of mitochondrial superoxide, MitoTEMPO (180 μg/kg/day, from pre-operative day 7 to post-operative day (POD) 21) infusion using an implanted mini-pump...
September 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28861391/time-series-analysis-of-patients-seeking-orthodontic-treatment-at-seoul-national-university-dental-hospital-over-the-past-decade
#5
Hyun-Woo Lim, Ji-Hoon Park, Hyun-Hee Park, Shin-Jae Lee
OBJECTIVE: This paper describes changes in the characteristics of patients seeking orthodontic treatment over the past decade and the treatment they received, to identify any seasonal variations or trends. METHODS: This single-center retrospective cohort study included all patients who presented to Seoul National University Dental Hospital for orthodontic diagnosis and treatment between January 1, 2005 and December 31, 2015. The study analyzed a set of heterogeneous variables grouped into the following categories: demographic (age, gender, and address), clinical (Angle Classification, anomaly, mode of orthodontic treatment, removable appliances for Phase 1 treatment, fixed appliances for Phase 2 treatment, orthognathic surgery, extraction, mini-plate, mini-implant, and patient transfer) and time-related variables (date of first visit and orthodontic treatment time)...
September 2017: Korean Journal of Orthodontics
https://www.readbyqxmd.com/read/28860871/first-in-man-intraglandular-implantation-of-stromal-vascular-fraction-and-adipose-derived-stem-cells-plus-platelet-rich-plasma-in-irradiation-induced-gland-damage-a-case-study
#6
Kristin Comella, Walter Bell
BACKGROUND: Stromal vascular fraction (SVF) is a mixture of cells which can be isolated from a mini-lipoaspirate of fat tissue. Platelet-rich plasma (PRP) is a mixture of growth factors and other nutrients which can be obtained from peripheral blood. Adipose-derived stem/stromal cells (ADSCs) can be isolated from fat tissue and expanded in culture. The SVF includes a variety of different cells such as ADSCs, pericytes, endothelial/progenitor cells, and a mix of different growth factors...
2017: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/28846730/role-of-amygdala-kisspeptin-in-pubertal-timing-in-female-rats
#7
Daniel A Adekunbi, Xiao Feng Li, Shengyun Li, Olufeyi A Adegoke, Bolanle O Iranloye, Ayodele O Morakinyo, Stafford L Lightman, Paul D Taylor, Lucilla Poston, Kevin T O'Byrne
To investigate the mechanism by which maternal obesity disrupts reproductive function in offspring, we examined Kiss1 expression in the hypothalamic arcuate (ARC) and anteroventral periventricular (AVPV) nuclei, and posterodorsal medial amygdala (MePD) of pre-pubertal and young adult offspring. Sprague-Dawley rats were fed either a standard or energy-dense diet for six weeks prior to mating and throughout pregnancy and lactation. Male and female offspring were weaned onto normal diet on postnatal day (pnd) 21...
2017: PloS One
https://www.readbyqxmd.com/read/28843033/hemodynamic-analysis-of-a-novel-bioresorbable-scaffold-in-porcine-coronary-artery-model
#8
Erhan Tenekecioglu, Ryo Torii, Christos V Bourantas, Rafael Cavalcante, Yohei Sotomi, Yaping Zeng, Carlos Collet, Tom Crake, Alexandre Abizaid, Yoshinobu Onuma, Solomon Su, Teguh Santoso, Patrick W Serruys
BACKGROUND: The shear stress distribution assessment can provide useful insights for the hemodynamic performance of the implanted stent/scaffold. Our aim was to investigate the effect of a novel bioresorbable scaffold, Mirage on local hemodynamics in animal models. METHOD: The main epicardial coronary arteries of 7 healthy mini-pigs were implanted with 11 Mirage Microfiber sirolimus-eluting Bioresorbable Scaffolds (MMSES). Optical coherence tomography (OCT) was performed post scaffold implantation and the obtained images were fused with angiographic data to reconstruct the coronary artery anatomy...
August 26, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28841595/evaluation-of-palatal-bone-thickness-for-insertion-of-orthodontic-mini-implants-in-adults-and-adolescents
#9
Manying Wang, Yang Sun, Yuncheng Yu, Xiaojun Ding
OBJECTIVE: The aim of this study was to measure palatal bone thickness and select relatively safe regions for mini-implant insertion, and to determine the effect of age and sex on palatal bone thickness and whether there is any difference between right and left sides. MATERIALS AND METHODS: Cone beam computed tomographic (CBCT) evaluation was used on 107 healthy orthodontic patients, including 51 adolescents (12.90 ± 1.71 years) and 56 adults (26.09 ± 4...
September 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28840411/long-term-durability-of-orthodontic-mini-implants
#10
Mona Aly Abbassy, Ahmed Samir Bakry, Khalid Hashim Zawawi, Ali Habib Hassan
The current study aimed at examining surface and chemical composition changes of retrieved mini-implants after different periods of service as aids of anchorage for orthodontic patients. This study examined 72 retrieved orthodontic self-tapping and self-drilling mini-implants, 1.7 mm in diameter and 8 mm in length (OrthoEasy system, Forestadent, Pforzheim, Germany) from 36 adult orthodontic patients (18 men and 18 women, mean age = 23 years). The retrieved mini-implants were divided into 3 groups according to service period: 3-6 months (3M-6M) group, 6-12 months (6M-12M) group, and 12-24 months (12M-24M) group, with 24 mini-implants in each group...
August 24, 2017: Odontology
https://www.readbyqxmd.com/read/28830759/phencyclidine-like-in%C3%A2-vivo-effects-of-methoxetamine-in-mice-and-rats
#11
Michael D Berquist, William S Hyatt, Jonathan Bauer-Erickson, Brenda M Gannon, Andrew P Norwood, William E Fantegrossi
Methoxetamine (MXE) is a novel drug of abuse that is structurally similar to phencyclidine (PCP). In the present study, rats were trained to discriminate PCP from saline and substitution tests were performed with arylcyclohexylamines PCP, eticyclidine (PCE), tenocyclidine (TCP), and MXE. PCP and PCE engendered PCP-lever selection in all subjects, whereas MXE and TCP produced PCP-lever selection in animals that did not display behavioral disruption. Last, the substituted tryptamine dipropyltryptamine (DPT) produced moderate PCP-lever selection and elicited behavioral disruption in all subjects at the highest dose tested...
August 19, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28819826/the-outcome-of-the-partial-resurfacing-arthroplasty-of-the-hip-shows-high-numbers-of-failures-and-conversion-to-total-arthroplasty
#12
Thilo Floerkemeier, Stefan Budde, Nils Wirries, Gabriela von Lewinski, Henning Windhagen, Marco Ezechieli
PURPOSE: Local cartilage and bony defects, which are too large for joint preserving cartilage treatment are difficult to treat. The implantation of a mini-resurfacing implant (Hemicap®, 2med, Hamburg, Germany) may be a possible alternative treatment for these patients. This partial replacement fills the defect and restores a smooth and continuous articular surface. The aim of this study was to determine short- to midterm results of the treatment of local cartilage defects of the femoral head using the Hemicap®...
August 17, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28817740/influence-of-microtextured-implant-surfaces-on-peri-implantitis-and-its-treatment-a-preclinical-trial
#13
Juan C Rodriguez, Tapan Koticha, Diana L Eubanks, Ivan Rudek, Fred J Molz, Ludovica Chiavaccini, Andrew Claude, Steven Elder, Hom-Lay Wang
PURPOSE: The prevalence of peri-implantitis has increased significantly, forcing clinicians to search for ways to prevent it. Laser-microtextured surfaces promote soft tissue attachment and provide a tight seal around implants. Hence, the aim of this study was to examine the clinical, radiographic, and histologic features of ligature-induced peri-implantitis, as well as the effect of surgical treatment of these induced peri-implantitis lesions on laser-microtextured implants in a controlled animal model...
August 17, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28814861/the-influence-of-direct-laser-metal-sintering-implants-on-the-early-stages-of-osseointegration-in-diabetic-mini-pigs
#14
Naiwen Tan, Xiangwei Liu, Yanhui Cai, Sijia Zhang, Bo Jian, Yuchao Zhou, Xiaoru Xu, Shuai Ren, Hongbo Wei, Yingliang Song
BACKGROUND: High failure rates of oral implants have been reported in diabetic patients due to the disruption of osseointegration. The aim of this study was to investigate whether direct laser metal sintering (DLMS) could improve osseointegration in diabetic animal models. METHODS: Surface characterizations were carried out on two types of implants. Cell morphology and the osteogenic-related gene expression of MG63 cells were observed under conditions of DLMS and microarc oxidation (MAO)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28806342/cognitive-abilities-and-quality-of-life-after-cochlear-implantation-in-the-elderly
#15
Marie-Hortense Sonnet, Bettina Montaut-Verient, Jean-Yves Niemier, Michel Hoen, Laurence Ribeyre, Cécile Parietti-Winkler
OBJECTIVE: To evaluate quality of life (QoL) and cognitive function in elderly patients with cochlear implants relative to auditory improvement, using geriatric validated scales. STUDY DESIGN: Prospective observational study. SETTING: A tertiary referral center for cochlear implantation (CI) and a geriatric center in Nancy, France. PATIENTS: Sixteen consecutive patients were included, from 65 to 80 years old, with postlingual severe-to-profound deafness...
September 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28796827/impact-of-ghrelin-on-body-composition-and-muscle-function-in-a-long-term-rodent-model-of-critical-illness
#16
Neil E Hill, Kevin G Murphy, Saima Saeed, Rahul Phadke, Darren Chambers, Duncan R Wilson, Stephen J Brett, Mervyn Singer
BACKGROUND: Patients with multiple injuries or sepsis requiring intensive care treatment invariably develop a catabolic state with resultant loss of lean body mass, for which there are currently no effective treatments. Recovery can take months and mortality is high. We hypothesise that treatment with the orexigenic and anti-inflammatory gastric hormone, ghrelin may attenuate the loss of body mass following critical illness and improve recovery. METHODS: Male Wistar rats received an intraperitoneal injection of the fungal cell wall derivative zymosan to induce a prolonged peritonitis and consequent critical illness...
2017: PloS One
https://www.readbyqxmd.com/read/28749837/occlusion-guided-double-barreled-fibular-osteoseptocutaneous-free-flap-for-refined-mandibular-reconstruction-aided-by-virtual-surgical-planning
#17
Xingzhou Qu, Mingyi Wang, Liqun Xu, Jiannan Liu, Shizhu Bai, Chenping Zhang
BACKGROUND: There were many articles about double-barreled fibular flap for mandibular reconstruction. The upper layer bone was suit for implant placement as a new alveolar. The lower layer was necessary for contour. But the accurate relationship between the 2 layers bone was rarely reported. OBJECTIVES: The purpose of this study was twofold: to evaluate the feasibility of the novel design of the double-barreled fibular flap from virtual surgery to actual result; to evaluate the accuracy and results of occlusion-guided double-barreled fibular free flap in mandible reconstruction...
September 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28746487/fracture-strength-of-orthodontic-mini-implants
#18
Tatiana Feres Assad-Loss, Flávia Mitiko Fernandes Kitahara-Céia, Giordani Santos Silveira, Carlos Nelson Elias, José Nelson Mucha
Objective: This study aimed at evaluating the design and dimensions of five different brands of orthodontic mini-implants, as well as their influence on torsional fracture strength. Methods: Fifty mini-implants were divided into five groups corresponding to different manufactures (DEN, RMO, CON, NEO, SIN). Twenty-five mini-implants were subjected to fracture test by torsion in the neck and the tip, through arbors attached to a Universal Mechanical Testing Machine...
May 2017: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/28745215/nitroxyl-anion-mediates-relaxation-in-mesenteric-arteries-from-angiotensin-ii-hypertensive-mice
#19
Brandi M Wynne, Hicham Labazi, Rita C Tostes, R Clinton Webb
AIMS: Nitroxyl anion (HNO) has recently become an emerging candidate in vascular regulation. NO- is a potent vasodilator of both conduit and small resistance vessels and mediates relaxation in a soluble guanylate cyclase-dependent manner. Interestingly, HNO activates voltage-dependent K+ (K+V) channels, whereas nitric oxide (NO) activates calcium-activated K+ channels. To date, there are few studies investigating the role of HNO in hypertension, and the possible mechanisms, which may be altered during this condition...
July 25, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28733734/combined-in-vivo-and-ex-vivo-analysis-of-mesh-mechanics-in-a-porcine-hernia-model
#20
Lindsey G Kahan, Spencer P Lake, Jared M McAllister, Wen Hui Tan, Jennifer Yu, Dominic Thompson, L Michael Brunt, Jeffrey A Blatnik
BACKGROUND: Hernia meshes exhibit variability in mechanical properties, and their mechanical match to tissue has not been comprehensively studied. We used an innovative imaging model of in vivo strain tracking and ex vivo mechanical analysis to assess effects of mesh properties on repaired abdominal walls in a porcine model. We hypothesized that meshes with dissimilar mechanical properties compared to native tissue would alter abdominal wall mechanics more than better-matched meshes. METHODS: Seven mini-pigs underwent ventral hernia creation and subsequent open repair with one of two heavyweight polypropylene meshes...
July 21, 2017: Surgical Endoscopy
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