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JOURNAL ARTICLE
Yangyang Zhang, Liang Zhang, Pengcheng Ge, Ruyi Xu, Zhen Ye
BACKGROUND: Roxadustat is a novel oral medication used to treat anemia in CKD patients. Several studies have shown that Roxadustat can alleviate anemia in CKD patients by increasing hemoglobin levels and regulating iron metabolism. We aimed to evaluate the effect of Roxadustat on ventricular repolarization in PD patients. This study may provide a new integrated approach to the assessment and treatment of CKD. METHODS: The present prospective cohort study enrolled 65 CKD patients who were treated with Roxadustat and 31 CKD patients who received conventional therapy between January 2021 and June 2022...
October 11, 2023: European Journal of Medical Research
#22
JOURNAL ARTICLE
Chunyan Yi, Jing Guo, Yuanying Liu, Yao Chang, Jianxiong Lin, Fei Deng, Xiaoli Yu, Xiaodan Zhang, Qunying Guo, Haiping Mao, Wei Chen, Xiao Yang
OBJECTIVES: The aims of this study were to investigate the current status and the influence factors of exercise, and to explore the impact of exercise on the quality of life (QoL) in peritoneal dialysis (PD) patients in the post-COVID-19 period. MATERIALS AND METHODS: Those PD patients who were followed up between September 2020 and August 2021 were enrolled. The collected data included demographic information, clinical data, exercise data, and QoL. RESULTS: In total, 339 PD patients were included in this cross-sectional study...
October 5, 2023: Clinical Nephrology
#23
JOURNAL ARTICLE
Michał Nowicki, Maciej Drożdż, Jarosław Wajda, Wiesław Klatko, Agnieszka Segiet-Święcicka
BACKGROUND: Renal anemia is one of the most common complications of chronic kidney disease. This real-life study assessed the effectiveness of methoxy polyethylene glycol-epoetin beta, a continuous erythropoietin receptor activator (C.E.R.A.), for the treatment of chronic kidney disease (CKD)-associated anemia in patients receiving dialysis in daily clinical practice. METHODS: 247 patients receiving chronic intermitted dialysis in 26 centers in Poland with CKD-associated symptomatic anemia, ESA-naïve, and with balanced iron stores in the investigators' opinion were enrolled this real-life study...
September 14, 2023: Nephron
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EDITORIAL
Ana Carina Ferreira
High-quality and goal-directed peritoneal dialysis (PD) prescription should be provided to all PD patients. Prioritizing patients' goals is necessary for their quality of life, as it is assessment of volume and nutritional status, anemia and mineral and bone management, or small-solute removal. To optimize the removal of small solutes, and depending on membrane characteristics, the increase in concentration gradient difference or the increase in volume (recruitment of all peritoneal capacities) can be performed...
September 2023: Clinical Kidney Journal
#25
JOURNAL ARTICLE
Emre Leventoğlu, Bahar Büyükkaragöz, Furkan Çağrı Kavas, Mert Can Holoğlu, Akif Kavgacı, Kibriya Fidan, Aydın Dalgıç, Sevcan A Bakkaloğlu, Fatma Sedef Tunaoğlu, Oğuz Söylemezoğlu
Cardiovascular diseases are the main causes of morbidity in children with chronic kidney disease (CKD). Electrocardiography (ECG) can provide important information about cardiac functions and parameters associated with sudden cardiac death. This study aims to evaluate the potentially dangerous changes in CKD and kidney replacement therapies by ECG and to determine the value of ECG in predicting cardiovascular outcome compared with echocardiography. 101 patients with CKD were divided into subgroups according to treatment modalities as pre-dialysis CKD, hemodialysis (HD), peritoneal dialysis (PD) and kidney transplantation (KTx)...
November 2023: European Journal of Pediatrics
#26
JOURNAL ARTICLE
Jia-Lin Li, Zhen Cai, Jing Zhao, Xiang-Gang Zhu, Qian Li, Yan-Shuang Li, Meng-Chao Liu, Fang-Qiang Cui, Wen-Jing Zhao, Wen-Quan Niu
Objectives: The study aimed to examine the association of three anemia-related biomarkers with the adequacy of peritoneal dialysis (PD) in patients with chronic kidney disease (CKD). Methods: This study included 127 PD patients. The total Kt/V urea (Kt/V) was calculated according to the Kidney Disease Outcomes Quality Initiative (K/DOQI) guidelines. All patients were classified into two groups based on Kt/V, viz., adequate (Kt/V ≥1.7) and inadequate (Kt/V <1.7) groups. Effect sizes are expressed as odds ratios (ORs) and 95% confidence interval (CI)...
2023: Frontiers in Physiology
#27
JOURNAL ARTICLE
Andrzej Breborowicz
BACKGROUND: Treatment of anemia in peritoneal dialysis patients often requires intravenous iron supplementation. Iron diffuses into the peritoneal cavity and is injurious to the peritoneum. We studied how intermittent exposure to iron changes the properties of the senescent peritoneal mesothelial cells (MC). METHODS: Replicative senescence was induced in MC in control medium (Con) or in control medium with intermittent exposure to iron isomaltoside 15 µg/dL (Con-IIS)...
August 11, 2023: International Journal of Artificial Organs
#28
JOURNAL ARTICLE
Tomasz Głogowski, Ewa Wojtaszek, Jolanta Malyszko
BACKGROUND: Characteristics of peritoneal membrane is unique and individually different in peritoneal dialysis patients. Relationship between specific nature of peritoneal transport, anemia and inflammation has not yet been extensively studied. We attempted to outline the complex interplay of several biomarkers of iron status and their association with peritoneal transport, degree of inflammation and residual renal function. METHODS: A total of 58 patients treated with peritoneal dialysis either CAPD or APD for at least 3 months were enrolled in this study...
2023: Frontiers in Medicine
#29
Maria Gabriela Motta Guimarães, Fernanda Pinheiro Martin Tapioca, Felipe Costa Neves, José A Moura-Neto, Luiz Carlos Santana Passos
BACKGROUND: Anemia is a common finding among patients with advanced chronic kidney disease, especially those on dialysis. The recent introduction of hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) has raised some concerns about the cardiovascular and thrombotic complications of this class of drugs. OBJECTIVES: This meta-analysis aimed to assess the safety of HIF-PHIs in patients with end-stage kidney disease (ESKD) versus standard therapy with erythropoiesis-stimulating agents (ESAs)...
July 17, 2023: Blood Purification
#30
JOURNAL ARTICLE
Cut-off values of hemoglobin and clinical outcomes in incident peritoneal dialysis: the PDTAP study.
Xiao Xu, Zhikai Yang, Shaomei Li, Huayi Pei, Jinghong Zhao, Ying Zhang, Zibo Xiong, Yumei Liao, Ying Li, Qiongzhen Lin, Wenbo Hu, Yulin Li, Zhaoxia Zheng, Liping Duan, Gang Fu, Shanshan Guo, Beiru Zhang, Rui Yu, Fuyun Sun, Xiaoying Ma, Li Hao, Guiling Liu, Zhanzheng Zhao, Jing Xiao, Yulan Shen, Yong Zhang, Xuanyi Du, Tianrong Ji, Caili Wang, Lirong Deng, Yingli Yue, Shanshan Chen, Zhigang Ma, Yingping Li, Li Zuo, Huiping Zhao, Xianchao Zhang, Xuejian Wang, Yirong Liu, Xinying Gao, Xiaoli Chen, Hongyi Li, Shutong Du, Cui Zhao, Zhonggao Xu, Li Zhang, Hongyu Chen, Li Li, Lihua Wang, Yan Yan, Yingchun Ma, Yuanyuan Wei, Jingwei Zhou, Yan Li, Yingdong Zheng, Jinwei Wang, Ming-Hui Zhao, Jie Dong
AIMS: To explore the cut-off values of hemoglobin on adverse clinical outcomes in the incident PD patients based on a national-level database. METHODS: The observational cohort study was from the Peritoneal Dialysis Telemedicine-assisted Platform (PDTAP) dataset. The primary outcomes were all-cause mortality, major adverse cardiovascular events (MACE) and modified MACE + . The secondary outcomes were the occurrences of hospitalization, first-episode peritonitis, permanent transfer to hemodialysis...
July 17, 2023: Nephrology, Dialysis, Transplantation
#31
JOURNAL ARTICLE
Shuiqin Cheng, Tingting Zhou, Le Yu, Zhihong Zhang, Yunmin Chen, Man Zhang, Jingjing Cui, Wenxin Yu, Jian Zhou, Yusheng Yu
INTRODUCTION: Roxadustat treatment in PD patients is equivalent to ESAs in increasing hemoglobin (Hb). But blood pressure, cardiovascular parameters, cardio-cerebrovascular complications and prognosis in the two groups before and after treatment has not been sufficiently discussed. METHODS: Sixty PD patients who were treated with roxadustat for renal anemia in our PD center recruited from June 2019 to April 2020 as roxadustat group. PD patients treated with rHuEPO were enrolled at a 1:1 ratio as rHuEPO group using the method of propensity score matching...
2023: Frontiers in Medicine
#32
REVIEW
Beatrice Drambarean, Justyna Mastalerz, Lisa Wendt, Stephanie Toth-Manikowski
PURPOSE: Successful pregnancy rates on dialysis are increasing with the advent of intensive hemodialysis and advances in medical management. SUMMARY: Data support the use of intensive hemodialysis in pregnant women with end-stage kidney disease (ESKD). This paper provides an overview of common pharmacotherapeutic changes in management when caring for a pregnant woman receiving intensive hemodialysis. Pregnant patients on peritoneal dialysis were excluded from this analysis due to insufficient data...
July 2023: Hemodialysis International
#33
JOURNAL ARTICLE
Ganesh Sritheran Paneerselvam, Khang Wen Goh, Yaman Walid Kassab, Muhammad Junaid Farrukh, Bey Hing Goh, Pei Lin Lua, Andi Hermansyah, Long Chiau Ming
BACKGROUND: End-stage renal disease is the last stage of chronic kidney disease and can affect the quality of life (QOL) of dialysis patients. The aim of this study was to assess the quality of life and examine its determinants. METHODS: A cross-sectional survey involving patients on dialysis in a tertiary hospital was conducted from July 2020 to September 2020. Demographic data were collected using a predesigned questionnaire. QOL was measured using the 36-item KDQOL questionnaire, and statistical analysis was carried out using SPSS version 25...
2023: Frontiers in Medicine
#34
Jian-Min Ren, Xiao-Yao Zhang, Si-Yu Liu
BACKGROUND: Neisseria mucosa is a gram negative diplococcus belonging to the genus Neisseria found commonly in the upper respiratory tract. It is typically a commensal organism when it is parasitic on oral and nasal mucosa. To our knowledge, it does not cause disease in healthy individuals with normal immunity, but can be pathogenic in those with impaired immune function or change in bacterial colonization site. Neisseria mucosa has been reported to cause bacterial meningitis, conjunctivitis, pneumonia, endocarditis, peritonitis and urethritis...
May 16, 2023: World Journal of Clinical Cases
#35
JOURNAL ARTICLE
Zhaoli Gao, Yingying Hu, Yanxia Gao, Xiaotian Ma, Zhao Hu
Hepcidin is an essential regulator of iron homeostasis in chronic kidney disease (CKD) anemia, reticulocyte hemoglobin equivalent (RET-He) can be used to evaluate the availability of iron for erythropoiesis. Previous research has found that hepcidin indirectly regulates RET-He. This study aimed to investigate the association of hepcidin, RET-He and anemia-related indicators on anemia in chronic kidney disease. A total of 230 individuals were recruited, including 40 CKD3-4 patients, 70 CKD5 patients without renal replacement therapy, 50 peritoneal dialysis patients, and 70 hemodialysis patients...
April 25, 2023: Medicine (Baltimore)
#36
JOURNAL ARTICLE
Mark J Sarnak, Rajiv Agarwal, Neil Boudville, Pradip C P Chowdhury, Kai-Uwe Eckardt, Carlos R Gonzalez, Laura A Kooienga, Mark J Koury, Kwabena A Ntoso, Wenli Luo, Patrick S Parfrey, Dennis L Vargo, Wolfgang C Winkelmayer, Zhiqun Zhang, Glenn M Chertow
BACKGROUND: Hypoxia-inducible factor prolyl hydroxylase inhibitors such as vadadustat may provide an oral alternative to injectable erythropoiesis-stimulating agents for treating anemia in patients receiving peritoneal dialysis. In two randomized (1:1), global, phase 3, open-label, sponsor-blind, parallel-group, active-controlled noninferiority trials in patients with dialysis-dependent chronic kidney disease (INNO2VATE), vadadustat was noninferior to darbepoetin alfa with respect to cardiovascular safety and hematological efficacy...
April 24, 2023: Nephrology, Dialysis, Transplantation
#37
JOURNAL ARTICLE
Emma England, Maneka Sheffield, Penelope Poyah, David Clark, Jo-Anne Wilson
BACKGROUND: Iron deficiency anemia is common in patients with advanced chronic kidney disease (CKD). Ferric derisomaltose (FDI) enables iron repletion in a single dose, unlike other forms of iron for IV administration, which require multiple doses. Protocols are commonly used with other IV irons, but there are limited Canadian data for FDI, and no protocol exists. OBJECTIVES: To evaluate the efficacy and safety of FDI for patients with CKD and to ascertain information related to its use in Canadian provinces...
2023: Canadian Journal of Hospital Pharmacy
#38
JOURNAL ARTICLE
Yukio Maruyama, Keitaro Yokoyama, Chieko Higuchi, Tsutomu Sanaka, Yoshihide Tanaka, Ken Sakai, Yoshihiko Kanno, Munekazu Ryuzaki, Tsutomu Sakurada, Tatsuo Hosoya, Masaaki Nakayama
INTRODUCTION: Inadequate dialysis and fluid overload are corrected after starting combined therapy with peritoneal dialysis (PD) and hemodialysis (HD). However, the effects on anemia management has not been elucidated. METHODS: We conducted a prospective, multicenter, observational cohort study of 40 PD patients (age, 60 ± 10 years; male, 88%; median PD duration, 28 months) starting combined therapy and investigated changes in several clinical parameters, including erythropoiesis-stimulating agent (ESA) resistance index (ERI)...
March 10, 2023: Therapeutic Apheresis and Dialysis
#39
REVIEW
Karolina Kędzierska-Kapuza, Urszula Szczuko, Hanna Stolińska, Dimitra Rafailia Bakaloudi, Waldemar Wierzba, Małgorzata Szczuko
BACKGROUND: Increasingly, chronic kidney disease (CKD) is becoming an inevitable consequence of obesity, metabolic syndrome, and diabetes. As the disease progresses, and through dialysis, the need for and loss of water-soluble vitamins both increase. This review article looks at the benefits and possible risks of supplementing these vitamins with the treatment of CKD. METHODS: Data in the PubMed and Embase databases were analyzed. The keywords "chronic kidney disease", in various combinations, are associated with thiamin, riboflavin, pyridoxine, pantothenic acid, folates, niacin, cobalamin, and vitamin C...
February 8, 2023: Nutrients
#40
JOURNAL ARTICLE
Hongjian Ye, Jianxiong Lin, Xiaodan Zhang, Wei Chen, Haiping Mao, Jianying Li, Xueqing Yu, Xiao Yang
OBJECTIVE: The relationship between higher peritoneal protein clearance (PPCl) and hemoglobin (Hb) levels in peritoneal dialysis (PD) patients is unknown. We explored this relationship and interaction on all-cause mortality in this prospective cohort study with large number of PD patients. METHODS: We enrolled prevalent PD patients in a single PD center. Demographic characteristics and clinical and biochemical data were collected. The total amount of protein loss in the dialysate and PPCl corrected for serum albumin were calculated...
January 31, 2023: Journal of Renal Nutrition
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