Vivianne Morrison, Matthew Houpert, Jonathan Trapani, Asa Brockman, Philip Kingsley, Ketaki Katdare, Hillary Layden, Gabriela Nguena-Jones, Alexandra Trevisan, Kathleen Maguire-Zeiss, Lawrence Marnett, Gregory Bix, Rebecca Ihrie, Bruce Carter
Microglia are the primary phagocytes in the central nervous system and clear dead cells generated during development or disease. The phagocytic process shapes the microglia phenotype, which affects the local environment. A unique population of microglia resides in the ventricular-subventricular zone (V-SVZ) of neonatal mice, but how they influence the neurogenic niche is not well understood. Here, we demonstrate that phagocytosis contributes to a pro-neurogenic microglial phenotype in the V-SVZ and that these microglia phagocytose apoptotic cells via the engulfment receptor Jedi-1...
November 10, 2023: Cell Reports