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https://www.readbyqxmd.com/read/27908425/copper-accumulation-in-rodent-brain-astrocytes-a-species-difference
#1
Brendan Sullivan, Gregory Robison, Yulia Pushkar, John K Young, Kebreten F Manaye
Changes in Cu homeostasis have been implicated in multiple neurodegenerative diseases. Factors controlling and regulating the distribution of Cu in the brain remain largely unknown. We have previously reported that a sub-set of astrocytes in the subventricular zone (SVZ) contain Cu-rich aggregates. Here we expand previous studies with detailed X-ray fluorescent imaging (XRF) analysis of the additional brain areas of hippocampus (HP) and rostral migratory stream (RMS). We also use conventional DAB (3,3'-diaminobenzidine) staining which accesses both peroxidase and pseudo-peroxidase activities...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27900341/subventricular-zone-associated-glioblastoma-a-call-for-translational-research-to-guide-clinical-decision-making
#2
Andrew W Smith, Bhupesh Parashar, A Gabriella Wernicke
Glioblastoma (GBM) is both the most common and the most devastating primary cancer of the central nervous system, with an expected overall survival in most patients of about 14 months. Despite extensive research, outcomes for GBM have been largely unchanged since the introduction of temozolomide in 2005. We believe that in order to achieve a breakthrough in therapeutic management, we must begin to identify subtypes of GBM, and tailor treatment to best target a particular tumor's vulnerabilities. Our group has recently produced an examination of the clinical outcomes of radiation therapy directed at tumors that contact the subventricular zone (SVZ), the 3-5 mm lateral border of the lateral ventricles that contains the largest collection of neural stem cells in the adult brain...
2016: Neurogenesis (Austin, Tex.)
https://www.readbyqxmd.com/read/27889318/neurogenic-radial-glia-like-cells-in-meninges-migrate-and-differentiate-into-functionally-integrated-neurons-in-the-neonatal-cortex
#3
Francesco Bifari, Ilaria Decimo, Annachiara Pino, Enric Llorens-Bobadilla, Sheng Zhao, Christian Lange, Gabriella Panuccio, Bram Boeckx, Bernard Thienpont, Stefan Vinckier, Sabine Wyns, Ann Bouché, Diether Lambrechts, Michele Giugliano, Mieke Dewerchin, Ana Martin-Villalba, Peter Carmeliet
Whether new neurons are added in the postnatal cerebral cortex is still debated. Here, we report that the meninges of perinatal mice contain a population of neurogenic progenitors formed during embryonic development that migrate to the caudal cortex and differentiate into Satb2(+) neurons in cortical layers II-IV. The resulting neurons are electrically functional and integrated into local microcircuits. Single-cell RNA sequencing identified meningeal cells with distinct transcriptome signatures characteristic of (1) neurogenic radial glia-like cells (resembling neural stem cells in the SVZ), (2) neuronal cells, and (3) a cell type with an intermediate phenotype, possibly representing radial glia-like meningeal cells differentiating to neuronal cells...
November 17, 2016: Cell Stem Cell
https://www.readbyqxmd.com/read/27884724/optogenetic-stimulation-of-glutamatergic-neuronal-activity-in-the-striatum-enhances-neurogenesis-in-the-subventricular-zone-of-normal-and-stroke-mice
#4
Mingke Song, Shan Ping Yu, Osama Mohamad, Wenyuan Cao, Zheng Zachory Wei, Xiaohuan Gu, Michael Qize Jiang, Ling Wei
Neurogenesis in the subventricular zone (SVZ) of the adult brain may contribute to tissue repair after brain injuries. Whether SVZ neurogenesis can be upregulated by specific neuronal activity in vivo and promote functional recovery after stroke is largely unknown. Using the spatial and cell type specific optogenetic technique combined with multiple approaches of in vitro, ex vivo and in vivo examinations, we tested the hypothesis that glutamatergic activation in the striatum could upregulate SVZ neurogenesis in the normal and ischemic brain...
November 21, 2016: Neurobiology of Disease
https://www.readbyqxmd.com/read/27882335/id-ealizing-control-of-adult-subventricular-zone-neural-stem-precursor-cell-differentiation-for-cns-regeneration
#5
COMMENT
Christian Bohrer, Christian Schachtrup
The adult central nervous system (CNS) was considered a comparatively static tissue with little cell turnover. It is now well established that there is more plasticity than previously thought and that astrocytes act as neural stem/precursor cells (NSPCs) in the subventricular zone (SVZ). The discovery that these NSPCs can give rise to a limited number of new neurons, reactive astrocytes and oligodendrocytes contributing to brain repair in CNS disease, has raised hopes toward harnessing these cells for therapeutic interventions...
2016: Neurogenesis (Austin, Tex.)
https://www.readbyqxmd.com/read/27867091/development-and-aging-of-a-brain-neural-stem-cell-niche
#6
Joanne C Conover, Krysti L Todd
In the anterior forebrain, along the lateral wall of the lateral ventricles, a neurogenic stem cell niche is found in a region referred to as the ventricular-subventricular zone (V-SVZ). In rodents, robust V-SVZ neurogenesis provides new neurons to the olfactory bulb throughout adulthood; however, with increasing age stem cell numbers are reduced and neurogenic capacity is significantly diminished, but new olfactory bulb neurons continue to be produced even in old age. Humans, in contrast, show little to no new neurogenesis after two years of age and whether V-SVZ neural stem cells persist in the adult human brain remains unclear...
November 17, 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/27857231/quantitative-proteomic-analysis-of-age-related-subventricular-zone-proteins-associated-with-neurodegenerative-disease
#7
Xianli Wang, Chuanming Dong, Lixin Sun, Liang Zhu, Chenxi Sun, Rongjie Ma, Ke Ning, Bing Lu, Jinfu Zhang, Jun Xu
Aging is characterized by a progressive decline in the function of adult tissues which can lead to neurodegenerative disorders. However, little is known about the correlation between protein changes in the subventricular zone (SVZ) and neurodegenerative diseases with age. In the present study, neural stem cells (NSCs) were derived from the SVZ on postnatal 7 d, 1 m, and 12 m-old mice. With age, NSCs exhibited increased SA-β-gal activity and decreased proliferation and pool size in the SVZ zone, and were associated with elevated inflammatory chemokines and cytokines...
November 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27832087/subarachnoid-hemorrhage-promotes-proliferation-differentiation-and-migration-of-neural-stem-cells-via-bdnf-upregulation
#8
Wen-Di Lee, Kuo-Chuan Wang, Yi-Fen Tsai, Pin-Chun Chou, Li-Kai Tsai, Chung-Liang Chien
Patients who suffer from subarachnoid hemorrhage (SAH) usually have long-term neurological impairments. Endogenous neurogenesis might play a potential role in functional recovery after SAH; however, the underlying neurogenesis mechanism is still unclear. We assessed the extent of neurogenesis in the subventricular zone (SVZ) to better understand the neurogenesis mechanism after SAH. We performed a rat model of SAH to examine the extent of neurogenesis in the SVZ and assessed functional effects of the neurotrophic factors in the cerebrospinal fluid (CSF) on neural stem cells (NSCs) after SAH...
2016: PloS One
https://www.readbyqxmd.com/read/27782828/spatial-transcriptome-analysis-reveals-notch-pathway-associated-prognostic-markers-in-idh1-wild-type-glioblastoma-involving-the-subventricular-zone
#9
Christine Jungk, Andreas Mock, Janina Exner, Christoph Geisenberger, Rolf Warta, David Capper, Amir Abdollahi, Sara Friauf, Bernd Lahrmann, Niels Grabe, Philipp Beckhove, Andreas von Deimling, Andreas Unterberg, Christel Herold-Mende
BACKGROUND: The spatial relationship of glioblastoma (GBM) to the subventricular zone (SVZ) is associated with inferior patient survival. However, the underlying molecular phenotype is largely unknown. We interrogated an SVZ-dependent transcriptome and potential location-specific prognostic markers. METHODS: mRNA microarray data of a discovery set (n = 36 GBMs) were analyzed for SVZ-dependent gene expression and process networks using the MetaCore™ workflow...
October 26, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27771498/ephrinb3-restricts-endogenous-neural-stem-cell-migration-after-traumatic-brain-injury
#10
Kirsty J Dixon, Jose Mier, Shyam Gajavelli, Alisa Turbic, Ross Bullock, Ann M Turnley, Daniel J Liebl
Traumatic brain injury (TBI) leads to a series of pathological events that can have profound influences on motor, sensory and cognitive functions. Conversely, TBI can also stimulate neural stem/progenitor cell proliferation leading to increased numbers of neuroblasts migrating outside their restrictive neurogenic zone to areas of damage in support of tissue integrity. Unfortunately, the factors that regulate migration are poorly understood. Here, we examine whether ephrinB3 functions to restrict neuroblasts from migrating outside the subventricular zone (SVZ) and rostral migratory stream (RMS)...
September 28, 2016: Stem Cell Research
https://www.readbyqxmd.com/read/27747480/treadmill-exercise-promotes-neurogenesis-in-ischemic-rat-brains-via-caveolin-1-vegf-signaling-pathways
#11
Yun Zhao, Qiongyi Pang, Meixia Liu, Jingzi Pan, Bingwu Xiang, Tingting Huang, Fengxia Tu, Chan Liu, Xiang Chen
Using a model of middle cerebral artery occlusion (MCAO), we have previously demonstrated that treadmill exercise promotes angiogenesis in the ischemic penumbra through caveolin-1/VEGF signaling pathways. However, the function of caveolin-1/VEGF signaling in neurogenesis after MCAO has not been determined. In this study, we aimed to investigate the potential of treadmill exercise to promote neurogenesis after MCAO and whether caveolin-1/VEGF signaling pathways are involved. After MCAO, rats were subjected to a program of treadmill exercise...
October 17, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27746720/hyperexpressed-netrin-1-promoted-neural-stem-cells-migration-in-mice-after-focal-cerebral-ischemia
#12
Haiyan Lu, Xiaoyan Song, Feng Wang, Guodong Wang, Yuncheng Wu, Qiaoshu Wang, Yongting Wang, Guo-Yuan Yang, Zhijun Zhang
Endogenous Netrin-1 (NT-1) protein was significantly increased after cerebral ischemia, which may participate in the repair after transient cerebral ischemic injury. In this work, we explored whether NT-1 can be steadily overexpressed by adeno-associated virus (AAV) and the exogenous NT-1 can promote neural stem cells migration from the subventricular zone (SVZ) region after cerebral ischemia. Adult CD-1 mice were injected stereotacticly with AAV carrying NT-1 gene (AAV-NT-1). Mice underwent 60 min of middle cerebral artery (MCA) occlusion 1 week after injection...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/27744570/neuroprotection-induced-by-transplanted-cdk5-knockdown-astrocytes-in-global-cerebral-ischemic-rats
#13
Andrea Becerra-Calixto, Gloria Patricia Cardona-Gómez
Cerebral ischemia is a cerebrovascular episode that generates a high incidence of death and physical and mental disabilities worldwide. Excitotoxicity, release of free radicals, and exacerbated immune response cause serious complications in motor and cognitive areas during both short and long time frames post-ischemia. CDK5 is a kinase that is widely involved in the functions of neurons and astrocytes, and its over-activation is implicated in neurodegenerative processes. In this study, we evaluated the brain parenchymal response to the transplantation of CDK5-knockdown astrocytes into the somatosensory cortex after ischemia in rats...
October 15, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27729188/irradiating-the-subventricular-zone-in-glioblastoma-patients-is-there-a-case-for-a-clinical-trial
#14
B Nourallah, R Digpal, R Jena, C Watts
Glioblastoma is the most common and aggressive adult brain tumour. Over the last 10 years it has emerged that the subventricular zone (SVZ), the largest adult neural stem cell niche, has an important role in the disease. Converging evidence has implicated transformation of adult neural stems in gliomagenesis and the permissive stem cell niche in disease recurrence. Concurrently, clinical studies have suggested that SVZ involvement is a negative prognostic marker. It would follow that irradiating the SVZ may improve outcomes in glioblastoma by directly targeting this putative sanctuary site...
October 8, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27723799/early-postnatal-lipopolysaccharide-exposure-leads-to-enhanced-neurogenesis-and-impaired-communicative-functions-in-rats
#15
Yi Pang, Xuemei Dai, Anna Roller, Kathleen Carter, Ian Paul, Abhay J Bhatt, Rick C S Lin, Lir-Wan Fan
Perinatal infection is a well-identified risk factor for a number of neurodevelopmental disorders, including brain white matter injury (WMI) and Autism Spectrum Disorders (ASD). The underlying mechanisms by which early life inflammatory events cause aberrant neural, cytoarchitectural, and network organization, remain elusive. This study is aimed to investigate how systemic lipopolysaccharide (LPS)-induced neuroinflammation affects microglia phenotypes and early neural developmental events in rats. We show here that LPS exposure at early postnatal day 3 leads to a robust microglia activation which is characterized with mixed microglial proinflammatory (M1) and anti-inflammatory (M2) phenotypes...
2016: PloS One
https://www.readbyqxmd.com/read/27720999/neurotrophin-3-promotes-proliferation-and-cholinergic-neuronal-differentiation-of-bone-marrow-derived-neural-stem-cells-via-notch-signaling-pathway
#16
Yu-Hui Yan, Shao-Heng Li, Zhong Gao, Sa-Feng Zou, Hong-Yan Li, Zhen-Yu Tao, Jie Song, Jing-Xian Yang
AIMS: Recently, the potential for neural stem cells (NSCs) to be used in the treatment of Alzheimer's disease (AD) has been reported; however, the therapeutic effects are modest by virtue of the low neural differentiation rate. In our study, we transfected bone marrow-derived NSCs (BM-NSCs) with Neurotrophin-3 (NT-3), a superactive neurotrophic factor that promotes neuronal survival, differentiation, and migration of neuronal cells, to investigate the effects of NT-3 gene overexpression on the proliferation and differentiation into cholinergic neuron of BM-NSCs in vitro and its possible molecular mechanism...
October 6, 2016: Life Sciences
https://www.readbyqxmd.com/read/27699791/increased-amyloid-precursor-protein-and-tau-expression-manifests-as-key-secondary-cell-death-in-chronic-traumatic-brain-injury
#17
Sandra A Acosta, Naoki Tajiri, Paul R Sanberg, Yuji Kaneko, Cesar V Borlongan
In testing the hypothesis of Alzheimer's disease (AD)-like pathology in late stage traumatic brain injury (TBI), we evaluated AD pathological markers in late stage TBI model. Sprague-Dawley male rats were subjected to moderate controlled cortical impact (CCI) injury, and 6 months later euthanized and brain tissues harvested. Results from H&E staining revealed significant 33% and 10% reduction in the ipsilateral and contralateral hippocampal CA3 interneurons, increased MHCII-activated inflammatory cells in many gray matter (8-20-fold increase) and white matter (6-30-fold increased) regions of both the ipsilateral and contralateral hemispheres, decreased cell cycle regulating protein marker by 1...
October 4, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27693047/expression-of-idh1-r132h-in-the-murine-subventricular-zone-stem-cell-niche-recapitulates-features-of-early-gliomagenesis
#18
Chiara Bardella, Osama Al-Dalahmah, Daniel Krell, Pijus Brazauskas, Khalid Al-Qahtani, Marketa Tomkova, Julie Adam, Sébastien Serres, Helen Lockstone, Luke Freeman-Mills, Inga Pfeffer, Nicola Sibson, Robert Goldin, Benjamin Schuster-Böeckler, Patrick J Pollard, Tomoyoshi Soga, James S McCullagh, Christopher J Schofield, Paul Mulholland, Olaf Ansorge, Skirmantas Kriaucionis, Peter J Ratcliffe, Francis G Szele, Ian Tomlinson
Isocitrate dehydrogenase 1 mutations drive human gliomagenesis, probably through neomorphic enzyme activity that produces D-2-hydroxyglutarate. To model this disease, we conditionally expressed Idh1(R132H) in the subventricular zone (SVZ) of the adult mouse brain. The mice developed hydrocephalus and grossly dilated lateral ventricles, with accumulation of 2-hydroxyglutarate and reduced α-ketoglutarate. Stem and transit amplifying/progenitor cell populations were expanded, and proliferation increased. Cells expressing SVZ markers infiltrated surrounding brain regions...
October 10, 2016: Cancer Cell
https://www.readbyqxmd.com/read/27675500/lack-of-evidence-that-high-dose-of-radiation-in-subventricle-zone-svz-can-improve-the-outcome-in-glioblastoma-gb-report-on-a-cohort-of-patients
#19
S Comas, S Villa, J M Velarde, J Molero, A Estival, P Teixidor, B Guitierrez, Y Luis, G Perez, C Panciroli, C Balana
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675262/impact-of-subventricular-zone-svz-irradiation-on-outcome-of-patients-with-glioblastoma-multiforme
#20
B S Mathew, S B Kaliyath, J Krishnan, S Bhasi
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
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