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https://www.readbyqxmd.com/read/28935237/prickle1-as-positive-regulator-of-oligodendrocyte-differentiation
#1
Rina Zilkha-Falb, Michael Gurevich, Erez Hanael, Anat Achiron
Spontaneous neural repair from endogenous neural stem cells (NSCs) niches occurs in response to central nervous system (CNS) injuries to only a limited extent. Uncovering the mechanisms that control neural repair and can be further manipulated to promote NSCs towards oligodendrocyte progenitors cells (OPCs) and myelinating oligodendrocytes is a major objective. In the current study, we describe high throughput transcriptional changes in adult mouse subventricular zone (SVZ)-NSCs during differentiation in vitro...
September 18, 2017: Neuroscience
https://www.readbyqxmd.com/read/28918258/olfactory-function-in-an-excitotoxic-model-for-secondary-neuronal-degeneration-role-of-dopaminergic-interneurons
#2
Concepció Marin, Sara Laxe, Cristobal Langdon, Joan Berenguer, Eduardo Lehrer, Franklin Mariño-Sánchez, Isam Alobid, Montserrat Bernabeu, Joaquim Mullol
Secondary neuronal degeneration (SND) occurring in Traumatic brain injury (TBI) consists in downstream destructive events affecting cells that were not or only marginally affected by the initial wound, further increasing the effects of the primary injury. Glutamate excitotoxicity is hypothesized to play an important role in SND. TBI is a common cause of olfactory dysfunction that may be spontaneous and partially recovered. The role of the glutamate excitotoxicity in the TBI-induced olfactory dysfunction is still unknown...
September 13, 2017: Neuroscience
https://www.readbyqxmd.com/read/28887094/salvianolic-acids-for-injection-safi-promotes-functional-recovery-and-neurogenesis-via-sonic-hedgehog-pathway-after-stroke-in-mice
#3
Ye Zhang, Xiangjian Zhang, Lili Cui, Rong Chen, Cong Zhang, Yaoru Li, Tingting He, Xingyuan Zhu, Zuyuan Shen, Lipeng Dong, Jingru Zhao, Ya Wen, Xiufen Zheng, Pan Li
There is a pressing need of developing approaches for delayed post-stroke therapy for patients who fail to receive thrombolysis within the narrow time window. Neuroprotection of Salvianolic Acids for Injection (SAFI) for cerebral ischemia-reperfusion injury in acute phase has been well documented. The current study was to determine the influence of SAFI at the subacute phase after stroke in mice, and to elucidate the underlying mechanisms. Adult male C57BL/6 mice were subjected to permanent occlusion of the distal middle cerebral artery (dMCAO), followed by daily intraperitoneal injection of SAFI 24 h after stroke for 14 days...
September 5, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28884398/developmental-exposure-of-decabromodiphenyl-ether-impairs-subventricular-zone-neurogenesis-and-morphology-of-granule-cells-in-mouse-olfactory-bulb
#4
Mingrui Xu, Yingxue Huang, Kaikai Li, Xinran Cheng, Guohong Li, Mengmeng Liu, Yufei Nie, Shu Geng, Shanting Zhao
Polybrominated diphenyl ethers (PBDEs) are additive flame retardants widely used in various products (e.g., textiles, consumer electronics, and plastics). Strong evidence indicates that PBDEs are developmental neurotoxicants that can cause neurodevelopmental disabilities and cognitive defects. Currently, decabromodiphenyl ether (BDE 209) is the only PBDE permitted for production in most countries. This study investigated the impact of BDE 209 on postnatal neurogenesis in the subventricular zone (SVZ) of ICR mice...
September 7, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28883785/early-postnatal-but-not-late-adult-neurogenesis-is-impaired-in-the-pitx3-mutant-animal-model-of-parkinson-s-disease
#5
Moritz D Brandt, Diana Krüger-Gerlach, Andreas Hermann, Anne K Meyer, Kwang-Soo Kim, Alexander Storch
The generation of new neurons in the adult dentate gyrus has functional implications for hippocampal formation. Reduced hippocampal neurogenesis has been described in various animal models of hippocampal dysfunction such as dementia and depression, which are both common non-motor-symptoms of Parkinson's disease (PD). As dopamine plays an important role in regulating precursor cell proliferation, the loss of dopaminergic neurons in the substantia nigra (SN) in PD may be related to the reduced neurogenesis observed in the neurogenic regions of the adult brain: subventricular zone (SVZ) and dentate gyrus (DG)...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28879461/perinatal-exposure-to-the-cyanotoxin-%C3%AE-n-m%C3%A3-thylamino-l-alanine-bmaa-results-in-long-lasting-behavioral-changes-in-offspring-potential-involvement-of-dna-damage-and-oxidative-stress
#6
Anthony Laugeray, Asma Oummadi, Clément Jourdain, Justyne Feat, Géraldine Meyer-Dilhet, Arnaud Menuet, Karen Plé, Marion Gay, Sylvain Routier, Stéphane Mortaud, Gilles J Guillemin
We recently demonstrated that perinatal exposure to the glutamate-related herbicide, glufosinate ammonium, has deleterious effects on neural stem cell (NSC) homeostasis within the sub-ventricular zone (SVZ), probably leading to ASD-like symptoms in offspring later in life. In the present study, we aimed to investigate whether perinatal exposure to another glutamate-related toxicant, the cyanobacterial amino acid β-N-methylamino-L-alanine (BMAA), might also trigger neurodevelopmental disturbances. With this aim, female mice were intranasally exposed to low doses of BMAA, 50 mg kg(-1) three times a week from embryonic days 7-10 to postnatal day 21...
September 6, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28875931/transient-hypothyroidism-favors-oligodendrocyte-generation-providing-functional-remyelination-in-the-adult-mouse-brain
#7
Sylvie Remaud, Fernando C Ortiz, Marine Perret-Jeanneret, Marie-Stéphane Aigrot, Jean-David Gothié, Csaba Fekete, Zsuzsanna Kvárta-Papp, Balázs Gereben, Dominique Langui, Catherine Lubetzki, Maria Cecilia Angulo, Bernard Zalc, Barbara Demeneix
In the adult brain, both neurons and oligodendrocytes can be generated from neural stem cells located within the Sub-Ventricular Zone (SVZ). Physiological signals regulating neuronal versus glial fate are largely unknown. Here we report that a thyroid hormone (T3)-free window, with or without a demyelinating insult, provides a favorable environment for SVZ-derived oligodendrocyte progenitor generation. After demyelination, oligodendrocytes derived from these newly-formed progenitors provide functional remyelination, restoring normal conduction...
September 6, 2017: ELife
https://www.readbyqxmd.com/read/28874134/amyotrophic-lateral-sclerosis-modifies-progenitor-neural-proliferation-in-adult-classic-neurogenic-brain-niches
#8
Lucía Galán, Ulises Gómez-Pinedo, Antonio Guerrero, Jose Manuel García-Verdugo, Jorge Matías-Guiu
BACKGROUND: Adult neurogenesis persists through life at least in classic neurogenic niches. Neurogenesis has been previously described as reduced in neurodegenerative diseases. There is not much knowledge about is adult neurogenesis is or not modified in amyotrophy lateral sclerosis (ALS). All previous publications has studied the ALS SOD1 (superoxide dismutase) transgenic mouse model. The purpose of this study is to examine the process of adult neurogenesis in classic niches (subventricular zone [SVZ] and subgranular zone [SGZ] of the dentate gyrus) in patients with amyotrophic lateral sclerosis (ALS), both with (ALS-FTD) and without associated frontotemporal dementia (FTD)...
September 6, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28871488/radio-protective-effects-of-melatonin-on-subventricular-zone-in-irradiated-rat-decrease-in-apoptosis-and-upregulation-of-nestin
#9
Shafigheh Naseri, Seyed Mohammad Hossein Noori Moghahi, Tahmineh Mokhtari, Mehrdad Roghani, Ali Reza Shirazi, Fatemeh Malek, Tayebeh Rastegar
Neural stem cells are self-renewing, multipotent cells that can be found in subventricular (SVZ) and subgranular (SGZ) zones of the brain. These zones are susceptible to irradiation-induced apoptosis and oxidative stress. Melatonin (MLT) is a natural protector of neural cells against toxicity. The aim of this study was to evaluate the effects of MLT as a radio-protective material effective in reducing tissue lesions in the SVZ of the brain and changing local apoptotic potential in rats. Twenty-five Gray irradiation was applied on adult rat brain for this study...
September 4, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28864354/methods-of-reactivation-and-reprogramming-of-neural-stem-cells-for-neural-repair
#10
REVIEW
Zuojun Tian, Qiuge Zhao, Sangita Biswas, Wenbin Deng
Research on the biology of adult neural stem cells (NSCs) and induced NSCs (iNSCs), as well as NSC-based therapies for diseases in central nervous system (CNS) has started to generate the expectation that these cells may be used for treatments in CNS injuries or disorders. Recent technological progresses in both NSCs themselves and their derivatives have brought us closer to therapeutic applications. Adult neurogenesis presents in particular regions in mammal brain, known as neurogenic niches such as the dental gyrus (DG) in hippocampus and the subventricular zone (SVZ), within which adult NSCs usually stay for long periods out of the cell cycle, in G0...
August 31, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28855864/persistent-decreases-in-adult-subventricular-and-hippocampal-neurogenesis-following-adolescent-intermittent-ethanol-exposure
#11
Wen Liu, Fulton T Crews
Neurogenesis in hippocampal dentate gyrus (DG) and subventricular zone (SVZ) matures during adolescence to adult levels. Binge drinking is prevalent in adolescent humans, and could alter brain neurogenesis and maturation in a manner that persists into adulthood. To determine the impact of adolescent binge drinking on adult neurogenesis, Wistar rats received adolescent intermittent ethanol (AIE) exposure (5.0 g/kg/day, i.g., 2 days on/2 days off from postnatal day, P25-P54) and sacrificed on P57 or P95. Neural progenitor cell proliferation, differentiation, survival and maturation using immunohistochemistry was determined in the DG and SVZ...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28854520/neuroplasticity-and-behavioral-effects-of%C3%A2-fluoxetine-after-experimental-stroke
#12
Yefei Sun, Xiaoyu Sun, Huiling Qu, Shanshan Zhao, Ting Xiao, Chuansheng Zhao
The brain can undergo self-repair and has the ability to compensate for functions lost after a stroke. The plasticity of the ischemic brain is influenced by several factors including aging and pharmacotherapy. Fluoxetine is an antidepressant which enhances serotonergic neurotransmission through selective inhibition of neuronal reuptake of serotonin. In clinical practice, fluoxetine alleviates the symptoms of post-stroke depression (PSD), helps motor recovery in stroke patients. In animal experiments, chronic administration of fluoxetine induces increased excitability of mature granule cells (GCs), enhancing axonal and dendritic reorganization, as well as promoting neurogenesis or angiogenesis in the dentate gurus (DG), but the effect of fluoxetine in the subventricular zone (SVZ) remains controversial...
August 24, 2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28836850/hiv-non-nucleoside-reverse-transcriptase-inhibitor-efavirenz-reduces-neural-stem-cell-proliferation-in-vitro-and-in-vivo
#13
Jingji Jin, Bethany Grimmig, James Izzo, Lecia A M Brown, Charles Hudson, Adam J Smith, Jun Tan, Paula C Bickford, Brian Giunta
The prevalence of HIV-associated neurocognitive disorders (HAND) remains high despite combination antiretroviral therapy (cART). There is evidence that neural stem cells (NSCs) can migrate to sites of brain injury such as those caused by inflammation and oxidative stress, which are pathological features of HAND. Thus, reductions in NSCs may contribute to HAND pathogenesis. Since the HIV non-nucleoside reverse transcriptase inhibitor efavirenz (EFV) has previously been associated with cognitive deficits and promotion of oxidative stress pathways, we examined its effect on NSCs in vitro as well as in C57BL/6J mice...
November 2016: Cell Transplantation
https://www.readbyqxmd.com/read/28833933/nscs-promote-hippocampal-neurogenesis-metabolic-changes-and-synaptogenesis-in-app-ps1-transgenic-mice
#14
Wei Zhang, Guo-Jun Gu, Qi Zhang, Jian-Hui Liu, Bo Zhang, Yi Guo, Mei-Yun Wang, Qi-Yong Gong, Xu Jian-Rong
Adult neurogenesis and synaptic remodeling persist as a unique form of structural and functional plasticity in the hippocampal dentate gyrus (DG) and subventricular zone (SVZ) of the lateral ventricles due to the existence of neural stem cells (NSCs). Transplantation of NSCs may represent a promising approach for the recovery of neural circuits. Here, we aimed to examine effects of highly neuronal differentiation of NSCs transplantation on hippocampal neurogenesis, metabolic changes and synaptic formation in APP/PS1 mice...
August 18, 2017: Hippocampus
https://www.readbyqxmd.com/read/28833685/drebrin-e-regulates-neuroblast-proliferation-and-chain-migration-in-the-adult-brain
#15
Yuki Kajita, Nobuhiko Kojima, Noriko Koganezawa, Hiroyuki Yamazaki, Kenji Sakimura, Tomoaki Shirao
F-actin-binding protein drebrin has two major isoforms: drebrin A and drebrin E. Drebrin A is the major isoform in the adult brain and is highly concentrated in dendritic spines, regulating spine morphology and synaptic plasticity. Conversely, drebrin E is the major isoform in the embryonic brain and regulates neuronal morphological differentiation, but it is also expressed in neurogenic regions of the adult brain. The subventricular zone (SVZ) is one of the brain regions where adult neurogenesis occurs. Neuroblasts migrate to the olfactory bulb (OB) and integrate into existing neuronal networks, after which drebrin expression changes from E to A, suggesting that drebrin E plays a specific role in neuroblasts in the adult brain...
August 22, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28814342/septal-contributions-to-olfactory-bulb-interneuron-diversity-in-the-embryonic-mouse-telencephalon-role-of-the-homeobox-gene-gsx2
#16
Shenyue Qin, Stephanie M Ware, Ronald R Waclaw, Kenneth Campbell
BACKGROUND: Olfactory bulb (OB) interneurons are known to represent diverse neuronal subtypes, which are thought to originate from a number of telencephalic regions including the embryonic dorsal lateral ganglionic eminence (dLGE) and septum. These cells migrate rostrally toward the OB, where they then radially migrate to populate different OB layers including the granule cell layer (GCL) and the outer glomerular layer (GL). Although previous studies have attempted to investigate regional contributions to OB interneuron diversity, few genetic tools have been used to address this question at embryonic time points when the earliest populations are specified...
August 16, 2017: Neural Development
https://www.readbyqxmd.com/read/28808445/targeting-adult-neurogenesis-for-poststroke-therapy
#17
REVIEW
Jianfei Lu, Anatol Manaenko, Qin Hu
Adult neurogenesis mainly occurs at the subventricular zone (SVZ) on the walls of the lateral ventricle and the subgranular zone (SGZ) of the dentate gyrus (DG). However, the majority of newborn neurons undergo programmed cell death (PCD) during the period of proliferation, migration, and integration. Stroke activates neural stem cells (NSCs) in both SVZ and SGZ. This process is regulated by a wide variety of signaling pathways. However, the newborn neurons derived from adult neurogenesis are insufficient for tissue repair and function recovery...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28804038/subependymomas-are-low-grade-heterogeneous-glial-neoplasms-defined-by-subventricular-zone-lineage-markers
#18
Randy S D'Amico, Moshe Praver, George J Zanazzi, Zachary Englander, Jennifer S Sims, Jorge L Samanamud, Alfred T Ogden, Paul C McCormick, Neil A Feldstein, Guy M McKhann, Michael B Sisti, Peter Canoll, Jeffrey N Bruce
OBJECTIVE: Subependymomas are infrequent, low-grade gliomas associated with the ventricular system and the spinal cord. Little is known about the origin and natural history of these slow-growing lesions. METHODS: We identified all patients with pathologically proven subependymomas presenting to our institution between 1998 and 2016. We retrospectively reviewed clinical, radiographic, histological, and surgical outcomes data in all patients who underwent surgical resection...
August 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28801522/vascular-niche-contribution-to-age-associated-neural-stem-cell-dysfunction
#19
Deana Marie Apple, Erzsebet Kokovay
Neural stem cells (NSCs) persist throughout life in the dentate gyrus and the ventricular-subventricular zone (V-SVZ), where they continuously provide new neurons and some glia. These cells are found in specialized niches that regulate quiescence, activation, differentiation, and cell fate choice. A key aspect of the regulatory niche is the vascular plexus, which modulates NSC behavior during tissue homeostasis and regeneration. During aging, NSCs become depleted and dysfunctional, resulting in reduced neurogenesis and poor brain repair...
August 11, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28801114/effects-of-curcumin-on-short-term-spatial-and-recognition-memory-adult-neurogenesis-and-neuroinflammation-in-a-streptozotocin-induced-rat-model-of-dementia-of-alzheimer-s-type
#20
Taysa B Bassani, Joelle M Turnes, Eric L R Moura, Jéssica M Bonato, Valentín Cóppola-Segovia, Silvio M Zanata, Rúbia M M W Oliveira, Maria A B F Vital
Curcumin is a natural polyphenol with evidence of antioxidant, anti-inflammatory and neuroprotective properties. Recent evidence also suggests that curcumin increases cognitive performance in animal models of dementia, and this effect would be related to its capacity to enhance adult neurogenesis. The aim of this study was to test the hypothesis that curcumin treatment would be able to preserve cognition by increasing neurogenesis and decreasing neuroinflammation in the model of dementia of Alzheimer's type induced by an intracerebroventricular injection of streptozotocin (ICV-STZ) in Wistar rats...
August 8, 2017: Behavioural Brain Research
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