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https://www.readbyqxmd.com/read/29752870/morphological-and-cellular-characterization-of-the-fetal-canine-canis-lupus-familiaris-subventricular-zone-rostral-migratory-stream-and-olfactory-bulb
#1
Dailiany Orechio, Bruna Andrade Aguiar, Giovanne Baroni Diniz, Jackson Cioni Bittencourt, Carlos A Haemmerle, Ii-Sei Watanabe, Maria Angelica Miglino, Patricia Castelucci
The existence of neurogenesis in the adult brain is a widely recognized phenomenon, occurring in the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone of the dentate gyrus in several vertebrate species. Neural precursors originated in the SVZ migrate to the main olfactory bulb (MOB), originating the rostral migratory stream (RMS) in the process. To better understand the formation of the adult neurogenic niches in dogs, we investigated the cellular composition and morphological organization of these areas in 57 days-old dog fetuses...
May 12, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29752725/identification-of-neun-immunopositive-cells-in-the-adult-mouse-subventricular-zone
#2
Kengo Saito, Taro Koike, Fumiaki Kawashima, Hirofumi Kurata, Taku Shibuya, Takemasa Satoh, Yoshio Hata, Hisao Yamada, Tetsuji Mori
In the adult rodent subventricular zone (SVZ), there are neural stem cells (NSCs) and the specialized neurogenic niche is critical to maintain their stemness. . To date, many cellular and non-cellular factors that compose the neurogenic niche and markers to identify subpopulations of Type A cells have been confirmed. In particular, neurotransmitters regulate adult neurogenesis and mature neurons in the SVZ have been only partially analyzed. Moreover, Type A cells, descendants of NSCs, are highly heterogeneous and more molecular markers are still needed to identify them...
May 11, 2018: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29748916/zbtb20-regulates-developmental-neurogenesis-in-the-olfactory-bulb-and-gliogenesis-after-adult-brain-injury
#3
Thorsten R Doeppner, Josephine Herz, Mathias Bähr, Anton B Tonchev, Anastassia Stoykova
The transcription factor (TF) Zbtb20 is important for the hippocampal specification and the regulation of neurogenesis of neocortical projection neurons. Herein, we show a critical involvement of the TF Zbtb20 in the neurogenesis of both projection neurons and interneurons of the olfactory bulb during embryonic stages. Our data indicate that the lack of Zbtb20 significantly diminishes the generation of a set of early-born Tbr2+ neurons during embryogenesis. Furthermore, we provide evidence that Zbtb20 regulates the transition between neurogenesis to gliogenesis in cortical radial glial progenitor cells at the perinatal (E18...
May 11, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29740309/expression-of-cyclin-d1-in-astrocytes-varies-during-aging
#4
Brigitte Ciapa, Sylvie Granon
D-Cyclins control progression through the G1 phase and the G1/S transition of the cell cycle. In the adult brain, they regulate neurogenesis which is limited to the sub-granular zone of the dentate gyrus (DG) and to the sub-ventricular zone (SVZ) of the lateral ventricles. Yet, D-cyclins have also been detected in other parts of the adult brain in differentiated neurons that do not proliferate and rather die by apoptosis in response to cell cycle reactivation. Expression of D-cyclins in astrocytes has also been reported but published results, such as those concerning neurons, appear conflictual...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29740265/transcriptional-profiling-of-ligand-expression-in-cell-specific-populations-of-the-adult-mouse-forebrain-that-regulates-neurogenesis
#5
Kasum Azim, Rainer Akkermann, Martina Cantone, Julio Vera, Janusz J Jadasz, Patrick Küry
In the adult central nervous system (CNS), the subventricular zone (SVZ) of the forebrain is the largest and most active source of neural stem cells (NSCs) that generates mainly neurons and few glial cells lifelong. A large body of evidence has shed light on the distinct families of signaling ligands (i.e., morphogens, growth factors, secreted molecules that alter signaling pathways) in regulating NSC biology. However, most of the research has focused on the mRNA expression of individual or few signaling ligands and their pathway components in specific cell types of the CNS in the context of neurogenesis...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29727663/single-cell-transcriptomics-and-fate-mapping-of-ependymal-cells-reveals-an-absence-of-neural-stem-cell-function
#6
Prajay T Shah, Jo A Stratton, Morgan Gail Stykel, Sepideh Abbasi, Sandeep Sharma, Kyle A Mayr, Kathrin Koblinger, Patrick J Whelan, Jeff Biernaskie
Ependymal cells are multi-ciliated cells that form the brain's ventricular epithelium and a niche for neural stem cells (NSCs) in the ventricular-subventricular zone (V-SVZ). In addition, ependymal cells are suggested to be latent NSCs with a capacity to acquire neurogenic function. This remains highly controversial due to a lack of prospective in vivo labeling techniques that can effectively distinguish ependymal cells from neighboring V-SVZ NSCs. We describe a transgenic system that allows for targeted labeling of ependymal cells within the V-SVZ...
May 3, 2018: Cell
https://www.readbyqxmd.com/read/29725291/neural-progenitors-in-the-developing-neocortex-of-the-northern-tree-shrew-tupaia-belangeri-show-a-closer-relationship-to-gyrencephalic-primates-than-to-lissencephalic-rodents
#7
Sebastian Römer, Hannah Bender, Wolfgang Knabe, Elke Zimmermann, Rudolf Rübsamen, Johannes Seeger, Simone A Fietz
The neocortex is the most complex part of the mammalian brain and as such it has undergone tremendous expansion during evolution, especially in primates. The majority of neocortical neurons originate from distinct neural stem and progenitor cells (NPCs) located in the ventricular and subventricular zone (SVZ). Previous studies revealed that the SVZ thickness as well as the abundance and distribution of NPCs, especially that of basal radial glia (bRG), differ markedly between the lissencephalic rodent and gyrencephalic primate neocortex...
2018: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/29698519/the-loss-of-the-kinases-sada-and-sadb-results-in-early-neuronal-apoptosis-and-a-reduced-number-of-progenitors
#8
Pratibha Dhumale, Sindhu Menon, Joanna Chiang, Andreas W Püschel
The neurons that form the mammalian neocortex originate from progenitor cells in the ventricular (VZ) and subventricular zone (SVZ). Newborn neurons are multipolar but become bipolar during their migration from the germinal layers to the cortical plate (CP) by forming a leading process and an axon that extends in the intermediate zone (IZ). Once they settle in the CP, neurons assume a highly polarized morphology with a single axon and multiple dendrites. The AMPK-related kinases SadA and SadB are intrinsic factors that are essential for axon formation during neuronal development downstream of Lkb1...
2018: PloS One
https://www.readbyqxmd.com/read/29686651/sex-steroids-and-adult-neurogenesis-in-the-ventricular-subventricular-zone
#9
REVIEW
Giovanna Ponti, Alice Farinetti, Marilena Marraudino, GianCarlo Panzica, Stefano Gotti
The forebrain ventricular-subventricular zone (V-SVZ) continuously generates new neurons throughout life. Neural stem cells (type B1 cells) along the lateral ventricle become activated, self-renew, and give rise to proliferating precursors which progress along the neurogenic lineage from intermediate progenitors (type C cells) to neuroblasts (type A cells). Neuroblasts proliferate and migrate into the olfactory bulb and differentiate into different interneuronal types. Multiple factors regulate each step of this process...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29680832/differential-fatty-acid-binding-protein-expression-in-persistent-radial-glia-in-the-human-and-sheep-subventricular-zone
#10
Birger Victor Dieriks, Justin M Dean, Eleonora Aronica, Henry J Waldvogel, Richard L M Faull, Maurice A Curtis
Fatty acid-binding proteins (FABPs) are a family of transport proteins that facilitate intracellular transport of fatty acids. Despite abundant expression in the brain, the role that FABPs play in the process of cell proliferation and migration in the subventricular zone (SVZ) remains unclear. Our results provide a detailed characterisation of FABP3, 5, and 7 expression in adult and fetal human and sheep SVZ. High FABP5 expression was specifically observed in the adult human SVZ and co-labelled with polysialylated neural cell adhesion molecule (PSA-NCAM), glial fibrillary acidic protein (GFAP), GFAPδ, and proliferating cell nuclear antigen (PCNA), indicating a role for FABP5 throughout the full maturation process of astrocytes and neuroblasts...
April 20, 2018: Developmental Neuroscience
https://www.readbyqxmd.com/read/29680253/longitudinal-study-of-irradiation-induced-brain-microstructural-alterations-with-s-index-a-diffusion-mri-biomarker-and-mr-spectroscopy
#11
Elodie Anne Pérès, Olivier Etienne, Antoine Grigis, Fawzi Boumezbeur, François Dominique Boussin, Denis Le Bihan
PURPOSE: Radiation therapy is widely used for the treatment of brain tumors, but it may lead to severe cognitive impairments. Previous studies have shown that ionizing irradiation induces demyelination, blood-brain barrier alterations, and impaired neurogenesis in animal models. Hence, noninvasive and sensitive biomarkers of irradiation injury are needed to investigate these effects in patients and improve radiation therapy protocols. METHODS AND MATERIALS: The heads of 3-month-old male C57BL/6RJ mice (15 control mice and 15 irradiated mice) were exposed to radiation doses of 3 fractions of 5 Gy from a 60 Co source with a medical irradiator...
February 2, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29675572/baicalin-modulates-appl2-glucocorticoid-receptor-signaling-cascade-promotes-neurogenesis-and-attenuates-emotional-and-olfactory-dysfunctions-in-chronic-corticosterone-induced-depression
#12
Chong Gao, Qiaohui Du, Wenting Li, Ruixia Deng, Qi Wang, Aimin Xu, Jiangang Shen
Olfactory dysfunction is often accompanied with anxiety- and depressive-like behaviors in depressive patients. Impaired neurogenesis in hippocampus and subventricular zone (SVZ)-olfactory bulb (OB) contribute to anxiety- and depressive-like behaviors and olfactory dysfunctions. However, the underlying mechanisms of olfactory dysfunction remain unclear. Our previous study indicates that adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (APPL2), could affect the activity and sensitivity of glucocorticoid receptor (GR) and mediate impaired hippocampal neurogenesis, which contribute the development of depression...
April 19, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29673477/symmetric-stem-cell-division-at-the-heart-of-adult-neurogenesis
#13
Violeta Silva-Vargas, Ana C Delgado, Fiona Doetsch
Obernier et al. (2018) show that the primary mode of division of adult ventricular-subventricular zone (V-SVZ) neural stem cells is symmetric, with the majority generating two non-stem cell progeny, and a minority self-renewing. This discovery has important implications for understanding stem cell dynamics and adult neurogenesis.
April 18, 2018: Neuron
https://www.readbyqxmd.com/read/29617679/simvastatin-attenuates-neurogenetic-damage-and-improves-neurocongnitive-deficits-induced-by-isoflurane-in-neonatal-rats
#14
Ning Wang, Yang Lu, Kui Wang, Wei-Song Li, Pan Lu, Shan Lei, Rong Li, Hong Zhang, Juan Zheng, Hai-Xia Lu, Xin-Lin Chen, Yong Liu, Peng-Bo Zhang
BACKGROUND/AIMS: Isoflurane inhibited neurogenesis and induced subsequent neurocognitive deficits in developing brain. Simvastatin exerts neuroprotection in a wide range of brain injury models. In the present study, we investigated whether simvastatin could attenuate neurogenetic inhibition and cognitive deficits induced by isoflurane exposure in neonatal rats. METHODS: Sprague-Dawley rats at postnatal day (PND) 7 and neural stem cells (NSCs) were treated with either gas mixture, isoflurane, or simvastatin 60 min prior to isoflurane exposure, respectively...
March 28, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29617675/neonatal-subventricular-zone-neural-stem-cells-release-extracellular-vesicles-that-act-as-a-microglial-morphogen
#15
Mary C Morton, Victoria N Neckles, Caitlin M Seluzicki, Jennie C Holmberg, David M Feliciano
Subventricular zone (SVZ) neural stem cells (NSCs) are the cornerstone of the perinatal neurogenic niche. Microglia are immune cells of the nervous system that are enriched in the neonatal SVZ. Although microglia regulate NSCs, the extent to which this interaction is bi-directional is unclear. Extracellular vesicles (EVs) are cell-derived particles that encase miRNA and proteins. Here, we demonstrate that SVZ NSCs generate and release EVs. Neonatal electroporated fluorescent EV fusion proteins were released by NSCs and subsequently cleared from the SVZ...
April 3, 2018: Cell Reports
https://www.readbyqxmd.com/read/29605425/stepwise-impairment-of-neural-stem-cell-proliferation-and-neurogenesis-concomitant-with-disruption-of-blood-brain-barrier-in-recurrent-ischemic-stroke
#16
Ruihe Lin, Michael Lang, Nicolette Heinsinger, Geoffrey Stricsek, Justine Zhang, Renato Iozzo, Robert Rosenwasser, Lorraine Iacovitti
Stroke patients are at increased risk for recurrent stroke and development of post-stroke dementia. In this study, we investigated the effects of recurrent stroke on adult brain neurogenesis using a novel rat model of recurrent middle cerebral artery occlusion (MCAO) developed in our laboratory. Using BrdU incorporation, activation and depletion of stem cells in the subgranular zone (SGZ) and subventricular zone (SVZ) were assessed in control rats and rats after one or two strokes. In vitro neurosphere assay was used to assess the effects of plasma from normal and stroke rats...
March 29, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29593498/reactive-neuroblastosis-in-huntington-s-disease-a-putative-therapeutic-target-for-striatal-regeneration-in-the-adult-brain
#17
Mahesh Kandasamy, Ludwig Aigner
The cellular and molecular mechanisms underlying the reciprocal relationship between adult neurogenesis, cognitive and motor functions have been an important focus of investigation in the establishment of effective neural replacement therapies for neurodegenerative disorders. While neuronal loss, reactive gliosis and defects in the self-repair capacity have extensively been characterized in neurodegenerative disorders, the transient excess production of neuroblasts detected in the adult striatum of animal models of Huntington's disease (HD) and in post-mortem brain of HD patients, has only marginally been addressed...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29593485/-till-death-do-us-part-a-potential-irreversible-link-between-aberrant-cell-cycle-control-and-neurodegeneration-in-the-adult-olfactory-bulb
#18
REVIEW
Saad Omais, Carine Jaafar, Noël Ghanem
Adult neurogenesis (AN) is an ongoing developmental process that generates newborn neurons in the olfactory bulb (OB) and the hippocampus (Hi) throughout life and significantly contributes to brain plasticity. Adult neural stem and progenitor cells (aNSPCs) are relatively limited in number and fate and are spatially restricted to the subventricular zone (SVZ) and the subgranular zone (SGZ). During AN, the distinct roles played by cell cycle proteins extend beyond cell cycle control and constitute key regulatory mechanisms involved in neuronal maturation and survival...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29579278/subchronic-manganese-exposure-impairs-neurogenesis-in-the-adult-rat-hippocampus
#19
Sherleen Xue-Fu Adamson, Xubo Shen, Wendy Jiang, Vivien Lai, Xiaoting Wang, Jonathan H Shannahan, Jason R Cannon, Jinhui Chen, Wei Zheng
Adult neurogenesis takes place in the brain subventricular zone (SVZ) in the frontal cortex and subgranular zone (SGZ) in the hippocampal dentate gyrus (HDG), and functions to supply newborn neurons for normal brain functionality. Subchronic Mn exposure is known to disrupt adult neurogenesis in the SVZ. This study was designed to determine whether Mn exposure disturbed neurogenesis within the adult HDG. Adult rats (10 weeks old) received a single dose of BrdU at the end of 4-wk Mn exposure to label the proliferating cells...
March 21, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29575648/spontaneous-development-of-intratumoral-heterogeneity-in-a-transposon-induced-mouse-model-of-glioma
#20
Keisuke Sumiyoshi, Hideto Koso, Sumiko Watanabe
Glioma is the most common form of malignant brain cancer in adults. The Sleeping Beauty (SB) transposon-based glioma mouse model allows for effective in vivo analysis of candidate genes. In this study, we developed a transposon vector that encodes the triple combination of platelet-derived growth factor subunit A (PDGFA), and shRNAs against Nf1 and Trp53 (shNf1/shp53). Initiation and progression of glioma in the brain were monitored by expression of a fluorescent protein. Transduction of the vector into neural progenitor and stem cells (NPCs) in the subventricular zone (SVZ) of the neonatal brain induced proliferation of oligodendrocyte precursor cells, and promoted formation of highly penetrant malignant gliomas within 2 to 4 months...
March 25, 2018: Cancer Science
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