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https://www.readbyqxmd.com/read/29051185/cgmp-elevating-compounds-and-ischemic-conditioning-provide-cardioprotection-against-ischemia-and-reperfusion-injury-via-cardiomyocyte-specific-bk-channels
#1
Sandra Frankenreiter, Piotr Bednarczyk, Angelina Kniess, Nadja Bork, Julia Straubinger, Piotr Koprowski, Antoni Wrzosek, Eva Mohr, Angela Logan, Michael P Murphy, Meinrad Gawaz, Thomas Krieg, Adam Szewczyk, Viacheslav O Nikolaev, Peter Ruth, Robert Lukowski
Background -The nitric oxide-sensitive guanylyl cyclase (NO-GC)/cyclic guanosine-3',5'-monophosphate (cGMP)/cGMP-dependent protein kinase type I (cGKI)-signaling pathway can afford protection against the ischemia and reperfusion (I/R) injury that occurs during myocardial infarction (MI). Reportedly, voltage and Ca(2+)-activated K(+) channels of the BK-type are stimulated by cGMP/cGKI and recent ex-vivo studies implicated that increased BK activity favors the survival of the myocardium at I/R. It remains unclear, however, whether the molecular events downstream of cGMP involve BK channels present in cardiomyocytes (CMs) or in other cardiac cell types...
October 19, 2017: Circulation
https://www.readbyqxmd.com/read/29023958/stroke-induced-chronic-systolic-dysfunction-driven-by-sympathetic-overactivity
#2
Michael Bieber, Rudolf A Werner, Edit Tanai, Ulrich Hofmann, Takahiro Higuchi, Kai Schuh, Peter U Heuschmann, Stefan Frantz, Oliver Ritter, Peter Kraft, Christoph Kleinschnitz
OBJECTIVE: Cardiac diseases are established risk factors for ischemic stroke incidence and severity. Conversely, there is increasing evidence that brain ischemia can cause cardiac dysfunction. The mechanisms underlying this neurogenic heart disease are incompletely understood. While it is established that ischemic stroke is associated with cardiac arrhythmias, myocardial damage, elevated cardiac enzymes and plasma catecholamines in the acute phase, nothing is known about the delayed consequences of ischemic stroke on cardiovascular function...
October 10, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29019935/cardiotoxic-effects-of-short-term-doxorubicin-administration-involvement-of-connexin-43-in-calcium-impairment
#3
Michela Pecoraro, Antonio Rodríguez-Sinovas, Stefania Marzocco, Michele Ciccarelli, Guido Iaccarino, Aldo Pinto, Ada Popolo
The use of Doxorubicin (DOXO), a potent antineoplastic agent, is limited by the development of cardiotoxicity. DOXO-induced cardiotoxicity is multifactorial, although alterations in calcium homeostasis, seem to be involved. Since even the Connexin43 (Cx43) plays a pivotal role in these two phenomena, in this study we have analyzed the effects of DOXO on Cx43 expression and localization. Damage caused by anthracyclines on cardiomyocytes is immediate after each injection, in the present study we used a short-term model of DOXO-induced cardiomyopathy...
October 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28989026/activation-of-nuclear-%C3%AE-catenin-c-myc-axis-promotes-oxidative-stress-injury-in-streptozotocin-induced-diabetic-cardiomyopathy
#4
Peng Liu, Jianfang Su, Xixi Song, Shixiao Wang
Myocardial oxidative stress injury plays a crucial role in the pathogenesis of diabetic cardiomyopathy (DCM). Wnt/β-catenin signaling has been reported to involve in various heart diseases. However, the underlying mechanism associated with β-catenin in DCM remains elusive. This study intended to explore the effect of β-catenin on oxidative damage of DCM by establishing streptozotocin (STZ)-induced diabetic mouse model and hydrogen peroxide (H2O2)-treated myocardial cell model. Cardiac oxidative stress in DCM was detected by measurements of lipid peroxidation and anti-oxidative enzyme activities as well as DHE staining...
October 6, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28982073/cardiac-specific-inactivation-of-lpp3-in-mice-leads-to-myocardial-dysfunction-and-heart-failure
#5
Mini Chandra, Diana Escalante-Alcalde, Md Shenuarin Bhuiyan, Anthony Wayne Orr, Christopher Kevil, Andrew J Morris, Hyung Nam, Paari Dominic, Kevin J McCarthy, Sumitra Miriyala, Manikandan Panchatcharam
Lipid Phosphate phosphatase 3 (LPP3), encoded by the Plpp3 gene, is an enzyme that dephosphorylates the bioactive lipid mediator lysophosphatidic acid (LPA). To study the role of LPP3 in the myocardium, we generated a cardiac specific Plpp3 deficient mouse strain. Although these mice were viable at birth in contrast to global Plpp3 knockout mice, they showed increased mortality ~ 8 months. LPP3 deficient mice had enlarged hearts with reduced left ventricular performance as seen by echocardiography. Cardiac specific Plpp3 deficient mice had longer ventricular effective refractory periods compared to their Plpp3 littermates...
September 28, 2017: Redox Biology
https://www.readbyqxmd.com/read/28977602/dipeptidyl-peptidase-4-inhibition-with-saxagliptin-ameliorates-angiotensin-ii-induced-cardiac-diastolic-dysfunction-in-male-mice
#6
Scott M Brown, Cassandra E Smith, Alex I Meuth, Maloree Khan, Annayya R Aroor, Hannah M Cleeton, Gerald A Meininger, James R Sowers, Vincent G DeMarco, Bysani Chandrasekar, Ravi Nistala, Shawn B Bender
Activation of the renin-angiotensin-aldosterone system is common in hypertension and obesity and contributes to cardiac diastolic dysfunction, a condition for which no treatment currently exists. In light of recent reports that antihyperglycemia incretin enhancing dipeptidyl peptidase (DPP)-4 inhibitors exert cardioprotective effects, we examined the hypothesis that DPP-4 inhibition with saxagliptin (Saxa) attenuates angiotensin II (Ang II)-induced cardiac diastolic dysfunction. Male C57BL/6J mice were infused with either Ang II (500 ng/kg/min) or vehicle for 3 weeks receiving either Saxa (10 mg/kg/d) or placebo during the final 2 weeks...
October 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28973678/l-carnitine-attenuates-cardiac-dysfunction-by-ischemic-insults-through-akt-signaling-pathway
#7
Mei Xue, Xu Chen, Zhija Guo, Xiaoqian Liu, Yanping Bi, Jie Yin, Haiyan Hu, Ping Zhu, Jian Zhuang, Courtney Cates, Thomas Rousselle, Ji Li
We aim to investigate the cardioprotective effects of L-carnitine on cardiac function during ischemia and reperfusion (I/R) and contractile function of single cardiomyocyte. C57BL/6J mice were randomly assigned to 5 groups: sham group; vehicle group, L-carnitine preconditioning group (LC), LC preconditioning + LY294002 (a PI3K/Akt signaling pathway inhibitor) group (LC + LY), and LY294002 group (LY). The sham group was exposed to the open heart operation but not ischemia/reperfusion, the other groups received 45 min ischemia/48 hrs reperfusion...
September 9, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28962186/ulinastatin-attenuates-diabetes-induced-cardiac-dysfunction-by-the-inhibition-of-inflammation-and-apoptosis
#8
Wen-Ke Wang, Qing-Hua Lu, Xin Wang, Ben Wang, Juan Wang, Hui-Ping Gong, Lin Wang, Hao Li, Yi-Meng Du
Ulinastatin exhibits anti-inflammatory activity and protects the heart from ischemia/reperfusion injury. However, whether ulinastatin has a protective effect in diabetic cardiomyopathy is yet to be elucidated. The aim of the present study was to investigate the protective effects of ulinastatin against diabetic cardiomyopathy and its underlying mechanisms. A C57/BL6J mice model of diabetic cardiomyopathy was used and mice were randomly assigned to three groups: Control group, diabetes mellitus (DM) group and DM + ulinastatin treatment group...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28962151/hesperetin-protects-against-inflammatory-response-and-cardiac-fibrosis-in-postmyocardial-infarction-mice-by-inhibiting-nuclear-factor-%C3%AE%C2%BAb-signaling-pathway
#9
Bing Wang, Lianghai Li, Ping Jin, Mengqiu Li, Jianguo Li
Cardiac inflammation and cardiac fibrosis are important parts of cardiac remodeling following myocardial infarction (MI), which may be the basic mechanisms of the development of chronic heart failure. The nuclear factor (NF)-κB signaling pathway promotes cardiac inflammation and fibrosis. It has reported that hesperetin inhibits cardiac remodeling induced by pressure overload in mice. However, it has remained elusive whether and how hesperetin has a role in cardiac fibrosis post-MI. Therefore, a mouse model of MI was established by left anterior descending coronary artery ligation...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28957802/overexpression-of-m3-muscarinic-receptor-suppressed-adverse-electrical-remodeling-in-hypertrophic-myocardium-via-increasing-repolarizing-k-currents
#10
Xue Chen, Yan Bai, Hanqi Sun, Zhenli Su, Jing Guo, Chuan Sun, Zhimin Du
BACKGROUND/AIMS: Cardiac hypertrophy (CH) is an adaptive response to diverse cardiovascular conditions, which is accompanied by adverse electrical remodeling manifested as abnormal K+ channel activities. M3 subtype of muscarinic acetylcholine receptor (M3-mAChR) is a novel regulator of cardiac electrical activity. In this study we aim to explore if the overexpression of M3-mAChR could attenuate the adverse electrical remodeling in CH and then uncover its underlying electrophysiological mechanisms...
September 29, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28951773/new-insights-and-new-hope-for-pulmonary-arterial-hypertension-natriuretic-peptides-clearance-receptor-as-a-novel-therapeutic-target-for-a-complex-disease
#11
Emmanuel Eroume-A Egom, Tiam Feridooni, Rebabonye B Pharithi, Barkat Khan, Haaris A Shiwani BSc, Vincent Maher, Yassine El Hiani, Robert A Rose, Kishore Bs Pasumarthi, Hilaire A Ribama
BACKGROUND: Pulmonary Arterial Hypertension (PAH) is a deadly and disabling disease for which there is no marketed drug that addresses the underlying disease mechanism and targets to cure patients. The lack of understanding of the disease mechanism represents the main challenges in developing curative therapies. We here report, for the first time, that mice lacking natriuretic peptides clearance receptor develop PAH. METHODS AND RESULTS: Initial studies assessed cardiac structure and function in NPR-C(+/+) (wild type) and age matched, littermate NPR-C(-/-) mice by echocardiography...
2017: International Journal of Physiology, Pathophysiology and Pharmacology
https://www.readbyqxmd.com/read/28948298/microrna-210-mediated-proliferation-survival-and-angiogenesis-promote-cardiac-repair-post-myocardial-infarction-in-rodents
#12
Mohammed Arif, Raghav Pandey, Perwez Alam, Shujia Jiang, Sakthivel Sadayappan, Arghya Paul, Rafeeq P H Ahmed
An innovative approach for cardiac regeneration following injury is to induce endogenous cardiomyocyte (CM) cell cycle re-entry. In the present study, CMs from adult rat hearts were isolated and transfected with cel-miR-67 (control) and rno-miR-210. A significant increase in CM proliferation and mono-nucleation were observed in miR-210 group, in addition to a reduction in CM size, multi-nucleation, and cell death. When compared to control, β-catenin and Bcl-2 were upregulated while APC (adenomatous polyposis coli), p16, and caspase-3 were downregulated in miR-210 group...
September 25, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28947563/cardiovascular-benefits-of-moderate-exercise-training-in-marfan-syndrome-insights-from-an-animal-model
#13
Aleksandra Mas-Stachurska, Anna-Maria Siegert, Monsterrat Batlle, Darya Gorbenko Del Blanco, Thayna Meirelles, Cira Rubies, Fabio Bonorino, Carla Serra-Peinado, Bart Bijnens, Julio Baudin, Marta Sitges, Lluís Mont, Eduard Guasch, Gustavo Egea
BACKGROUND: Marfan syndrome (MF) leads to aortic root dilatation and a predisposition to aortic dissection, mitral valve prolapse, and primary and secondary cardiomyopathy. Overall, regular physical exercise is recommended for a healthy lifestyle, but dynamic sports are strongly discouraged in MF patients. Nonetheless, evidence supporting this recommendation is lacking. Therefore, we studied the role of long-term dynamic exercise of moderate intensity on the MF cardiovascular phenotype...
September 25, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28942269/echocardiographic-strain-analysis-for-the-early-detection-of-myocardial-structural-abnormality-and-initiation-of-drug-therapy-in-a-mouse-model-of-dilated-cardiomyopathy
#14
Minjuan Zheng, Feng Pan, Ying Liu, Zhenzhou Li, Xiaodong Zhou, Xin Meng, Liwen Liu, Shuping Ge
This study aimed to evaluate the role of echocardiography-based strain analysis in the early diagnosis and guidance for management of dilated cardiomyopathy (DCM). Muscular dystrophy mice (which spontaneously develop DCM) and control (C57 BL/6 J) mice were sequentially evaluated by ultrasound biomicroscopy, conventional left ventricle (LV) measurement, two-dimensional (2-D) strain analysis and myocardial histologic analysis for 12 consecutive months. Significant alternation of LV remodeling and dysfunction could be detected by conventional echocardiography after 9 mo, by strain analysis after 5 mo and by histologic analysis after 4 mo...
September 20, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28941626/deletion-of-protein-tyrosine-phosphatase-1b-obliterates-endoplasmic-reticulum-stress-induced-myocardial-dysfunction-through-regulation-of-autophagy
#15
Shuyi Wang, Xiyao Chen, Sreejayan Nair, Dongdong Sun, Xiaoming Wang, Jun Ren
Endoplasmic reticulum (ER) stress has been demonstrated to prompt various cardiovascular risks although the underlying mechanism remains elusive. Protein tyrosine phosphatase-1B (PTP1B) serves as an essential negative regulator for insulin signaling. This study examined the role of PTP1B in ER stress-induced myocardial anomalies and underlying mechanism involved with a focus on autophagy. WT and PTP1B knockout mice were subjected to the ER stress inducer tunicamycin (1mg/kg). Cardiac function was evaluated with echocardiography and an Ion-Optix MyoCam system...
September 21, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28941596/robust-suppression-of-cardiac-energy-catabolism-with-marked-accumulation-of-energy-substrates-during-lipopolysaccharide-induced-cardiac-dysfunction-in-mice
#16
Yogi Umbarawan, Mas Rizky A A Syamsunarno, Hideru Obinata, Aiko Yamaguchi, Hiroaki Sunaga, Hiroki Matsui, Takako Hishiki, Tomomi Matsuura, Norimichi Koitabashi, Masaru Obokata, Hirofumi Hanaoka, Anwarul Haque, Fumio Kunimoto, Yoshito Tsushima, Makoto Suematsu, Masahiko Kurabayashi, Tatsuya Iso
BACKGROUND: Myocardial contractile dysfunction in sepsis has been attributed mainly to increased inflammatory cytokines, insulin resistance, and impaired oxidative phosphorylation of fatty acids (FAs). However, precise molecular mechanisms underlying the cardiac dysfunction in sepsis remain to be determined. We previously reported major shift in myocardial energy substrates from FAs to glucose, and increased hepatic ketogenesis in mice lacking fatty acid-binding protein 4 (FABP4) and FABP5 (DKO)...
September 20, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28935038/bone-marrow-derived-tenascin-c-attenuates-cardiac-hypertrophy-by-controlling-inflammation
#17
Lei Song, Lai Wang, Fuqiang Li, Ada Yukht, Minghui Qin, Haley Ruther, Mingjie Yang, Aurelio Chaux, Prediman K Shah, Behrooz G Sharifi
BACKGROUND: Tenascin-C (TNC) is a highly conserved matricellular protein with a distinct expression pattern during development and disease. Remodeling of the left ventricle (LV) in response to pressure overload leads to the re-expression of the fetal gene program. OBJECTIVES: The aim of this study was to investigate the function of TNC in cardiac hypertrophy in response to pressure overload. METHODS: Pressure overload was induced in TNC knockout and wild-type mice by constricting their abdominal aorta or by infusion of angiotensin II...
September 26, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28932356/interleukin-19-is-cardioprotective-in-dominant-negative-cyclic-adenosine-monophosphate-response-element-binding-protein-mediated-heart-failure-in-a-sex-specific-manner
#18
Danielle R Bruns, Alexander R Ghincea, Christian V Ghincea, Yasu-Taka Azuma, Peter A Watson, Michael V Autieri, Lori A Walker
AIM: To investigate the role of interleukin-19 (IL-19) in a murine model of female-dominant heart failure (HF). METHODS: Expression of one copy of a phosphorylation-deficient cyclic adenosine monophosphate response-element binding protein (dnCREB) causes HF, with accelerated morbidity and mortality in female mice compared to males. We assessed expression of IL-19, its receptor isoforms IL-20R α/β, and downstream IL-19 signaling in this model of female-dominant HF...
August 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28925017/early-treatment-with-resolvin-e1-facilitates-myocardial-recovery-from-ischemia-in-mice
#19
Guizhu Liu, Qian Liu, Yujun Shen, Deping Kong, Yanjun Gong, Bo Tao, Guilin Chen, Shumin Guo, Juanjuan Li, Shengkai Zuo, Yu Yu, Huiyong Yin, Li Zhang, Bin Zhou, Colin D Funk, Jian Zhang, Ying Yu
BACKGROUND AND PURPOSE: An appropriate inflammatory response is necessary for cardiac healing after acute myocardial infarction (MI). Resolvin E1 (RvE1) is an anti-inflammatory and pro-resolution lipid mediator derived from eicosapentaenoic acid. The purpose of this study was to investigate the potential effects of RvE1 on cardiac function recovery after MI in mice. EXPERIMENTAL APPROACH: Acute MI was induced by surgical ligation of the left anterior descending artery (LAD) in mice...
September 19, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28919891/moderate-intensity-exercise-affects-gut-microbiome-composition-and-influences-cardiac-function-in-myocardial-infarction-mice
#20
Zuheng Liu, Hai-Yue Liu, Haobin Zhou, Qiong Zhan, Wenyan Lai, Qingchun Zeng, Hao Ren, Dingli Xu
Physical exercise is commonly regarded as protective against cardiovascular disease (CVD). Recent studies have reported that exercise alters the gut microbiota and that modification of the gut microbiota can influence cardiac function. Here, we focused on the relationships among exercise, the gut microbiota and cardiac function after myocardial infarction (MI). Four-week-old C57BL/6J mice were exercised on a treadmill for 4 weeks before undergoing left coronary artery ligation. Cardiac function was assessed using echocardiography...
2017: Frontiers in Microbiology
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