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Androgenic alopecia

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https://www.readbyqxmd.com/read/29103134/androgenic-alopecia-in-a-postmenopausal-sicilian-baroness
#1
G Borzì, F Trimarchi, M Russo
No abstract text is available yet for this article.
November 4, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29101437/comparison-of-the-efficacy-of-homologous-and-autologous-platelet-rich-plasma-prp-for-treating-androgenic-alopecia
#2
Bilsev Ince, Mehmet Emin Cem Yildirim, Mehmet Dadaci, Mustafa Cihat Avunduk, Nedim Savaci
BACKGROUND: Androgenetic alopecia (AGA), the most common cause of hair loss in both sexes, accounts for 95% of all cases of hair loss. Although the literature has suggested that both nonactivated (n-PRP) and activated autologous (a-PRP) PRP can be used to treat AGA, we did not find any study investigating the use of homologous PRP (h-PRP) for this purpose. Also, to the best of our knowledge, there are no studies comparing the efficacy of h-PRP, a-PRP, or n-PRP on AGA therapy. OBJECTIVES: The aim of this study was to compare the increase in hair density, average number of platelets, complications, preparation, and duration of application in the treatment of AGA using a-PRP, n-PRP, and h-PRP...
November 3, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29090364/hematuria-and-hematospermia-associated-with-the-use-of-finasteride-for-the-treatment-of-androgenic-alopecia-a-case-report
#3
Abdel-Motaal M Fouda, Anees M Bazeed
In this report we address an unusual adverse effect of finasteride (Propecia 1 mg tablets) that was associated with painless hematuria and hematospermia in a 38-year-old healthy male during treatment of androgenic alopecia at a dose of 1 mg/day. It was found that the bleeding was linked to finasteride use as it occurred 2-3 days after use and stopped upon discontinuation of the drug. The patient was subjected to urological examination, laboratory investigations, and radiological imaging to identify the probable cause of bleeding...
October 31, 2017: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/29055061/preservation-of-stem-cells-in-androgenetic-alopecia
#4
Hend Gamil, Magda Assaf, Manal Elsayed, Khaled Gharib, Mohamed Soliman, Naglaa A Mostafa
Androgenetic alopecia is characterized by progressive, patterned hair loss from the scalp that occurs in both men and women. Suggested that genetically predisposed hair follicles are target for androgen-stimulated follicle miniaturization, with gradual replacement of terminal hairs by vellus hairs. We aimed at evaluating the expression of stem and progenitor cell markers using IHC in scalp biopsies from affected and unaffected areas of patients with AGA. This article is protected by copyright. All rights reserved...
October 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29046359/androgens-trigger-different-growth-responses-in-genetically-identical-human-hair-follicles-in-organ-culture-that-reflect-their-epigenetic-diversity-in-life
#5
Benjamin H Miranda, Matthew R Charlesworth, Desmond J Tobin, David T Sharpe, Valerie A Randall
Male sex hormones-androgens-regulate male physique development. Without androgen signaling, genetic males appear female. During puberty, increasing androgens harness the hair follicle's unique regenerative ability to replace many tiny vellus hairs with larger, darker terminal hairs (e.g., beard). Follicle response is epigenetically varied: some remain unaffected (e.g., eyelashes) or are inhibited, causing balding. How sex steroid hormones alter such developmental processes is unclear, despite high incidences of hormone-driven cancer, hirsutism, and alopecia...
October 18, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29034138/testosterone-pellet-associated-dermatitis-report-and-review-of-testopel-related-cutaneous-adverse-effects
#6
Lucas A Heldt Manica, Philip R Cohen
Testosterone replacement therapy is a treatment utilized for male hypogonadism. A subcutaneous testosterone pellet is a long-acting, slow-release delivery system that can be utilized as androgen replacement therapy. A 77-year-old man who was treated with testosterone pellets developed dermatitis consisting of erythematous plaques and patches on both buttocks and thighs within 28 days following the subcutaneous insertion of testosterone pellets. The skin lesions rapidly resolved with high-potency topical corticosteroid application...
August 11, 2017: Curēus
https://www.readbyqxmd.com/read/28979149/conventional-and-novel-stem-cell-based-therapies-for-androgenic-alopecia
#7
REVIEW
Dodanim Talavera-Adame, Daniella Newman, Nathan Newman
The prevalence of androgenic alopecia (AGA) increases with age and it affects both men and women. Patients diagnosed with AGA may experience decreased quality of life, depression, and feel self-conscious. There are a variety of therapeutic options ranging from prescription drugs to non-prescription medications. Currently, AGA involves an annual global market revenue of US$4 billion and a growth rate of 1.8%, indicating a growing consumer market. Although natural and synthetic ingredients can promote hair growth and, therefore, be useful to treat AGA, some of them have important adverse effects and unknown mechanisms of action that limit their use and benefits...
2017: Stem Cells and Cloning: Advances and Applications
https://www.readbyqxmd.com/read/28966516/comprehensive-transcriptome-profiling-of-balding-and-non-balding-scalps-in-trichorhinophalangeal-syndrome-type-i-patient
#8
Yun-Ji Kim, Byulee Yoon, Kyudong Han, Byung Cheol Park
BACKGROUND: Trichorhinophalangeal syndrome (TRPS) patients tend to have alopecia that appears to be androgenetic, and this genetic model might give clues to the pathogenesis of hair loss or hair morphogenesis. OBJECTIVE: This study was conducted to identify additional genetic evidence of TRPS and hair morphogenesis from a TRPS patient. METHODS: From one TRPS type I patient, we extracted RNA and profiled whole transcriptome in non-balding and balding scalp areas using high-throughput RNA sequencing...
October 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28941500/prostaglandin-d2-uses-components-of-ros-signaling-to-enhance-testosterone-production-in-keratinocytes
#9
Alon Mantel, J Tyson McDonald, Kennedy Goldsborough, Valerie M Harvey, Joanne Chan
Elevated levels of prostaglandin D2 (PGD2) have been shown to be present in the bald scalp of androgenic alopecia (AGA) patients and to functionally inhibit hair growth. However, its precise mechanism in AGA has yet to be clearly defined. Although testosterone plays a critical role in the initiation and progression of AGA, the existence of a possible link between PGD2 and testosterone in skin has not been investigated. Here we show that human keratinocytes treated with PGD2 show enhanced capacity to convert the weak androgen, androstenedione, to testosterone...
October 2017: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/28940857/prevalence-of-dermatologic-manifestations-and-metabolic-biomarkers-in-women-with-polycystic-ovary-syndrome-in-north-china
#10
Jin-Ge Feng, Yan Guo, Li-Ang Ma, Jin Xing, Rui-Feng Sun, Wei Zhu
BACKGROUND: Cutaneous features of hyperandrogenism in polycystic ovary syndrome (PCOS) include acne, hirsutism, seborrhea, androgenic alopecia (AGA), and acanthosis nigricans (AN). However, the relationships have not been well known broadly in terms of clinical hyperandrogenism and biochemical markers. OBJECTIVES: The aim of this study was to investigate biochemical and metabolic parameters in relation to cutaneous characters women in with and without PCOS. METHODS: This was a cross-sectional retrospective study including 186 women with PCOS and 113 age-matched without PCOS women...
September 21, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28932059/prevalence-of-nutritional-deficiencies-in-hair-loss-among-indian-participants-results-of-a-cross-sectional-study
#11
Dinesh Gowda, V Premalatha, D B Imtiyaz
BACKGROUND: Nutritional deficiencies are known to be associated with hair loss; however, the exact prevalence is not known. AIMS: The aim of this study is to evaluate the prevalence of nutritional deficiencies in participants with hair loss. MATERIALS AND METHODS: In this cross-sectional study, 100 enrolled participants were divided into telogen effluvium (TE), male-pattern hair loss (MPHL), and female-pattern hair loss (FPHL) based on the type of hair loss...
July 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28915843/protective-effects-of-gaba-against-metabolic-and-reproductive-disturbances-in-letrozole-induced-polycystic-ovarian-syndrome-in-rats
#12
Asad Ullah, Sarwat Jahan, Suhail Razak, Madeeha Pirzada, Hizb Ullah, Ali Almajwal, Naveed Rauf, Tayyaba Afsar
BACKGROUND: PCOs is a heterogeneous disorder with anovulation/oligo ovulation usually taken as oligo menorrhoea or amenorrhoea, hyperandrogenemia, hirsutism, acne, androgen alopecia and polycystic ovaries as the key diagnostic feathers. The study was undertaken to investigate the possible protective and ameliorating effects of GABA in Letrozole induced PCOS model in rats by targeting insulin resistance. METHODS: PCOs in Adult female rat was induced by the daily gastric administration of letrozole (1 mg/kg/day) in CMC (0...
September 15, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28912032/androgens-and-androgen-receptor-action-in-skin-and-hair-follicles
#13
REVIEW
Julieta María Ceruti, Gustavo José Leirós, María Eugenia Balañá
Beyond sexual functions, androgens exert their action in skin physiology and pathophysiology. Skin cells are able to synthesize most active androgens from gonadal or adrenal precursors and the enzymes involved in skin steroidogenesis are implicated both in normal or pathological processes. Even when the role of androgens and androgen receptor (AR) in skin pathologies has been studied for decades, their molecular mechanisms in skin disorders remain largely unknown. Here, we analyze recent studies of androgens and AR roles in several skin-related disorders, focusing in the current understanding of their molecular mechanisms in androgenetic alopecia (AGA)...
September 12, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28905175/the-promotion-of-hair-regrowth-by-topical-application-of-a-perilla-frutescens-extract-through-increased-cell-viability-and-antagonism-of-testosterone-and-dihydrotestosterone
#14
Jing-Jie Li, Zheng Li, Li-Juan Gu, Kang-Ju Choi, Dong-Seon Kim, Ho-Kyoung Kim, Chang-Keun Sung
This study investigated the potential hair regrowth effects associated with a plant extract of Perilla frutescens, which was selected due to its putative hair regrowth activity. Extracts were prepared from dried P. frutescens suspended in distilled water, where the resultant aqueous suspension was fractionated sequentially using hexane, ethyl acetate, n-butanol, and distilled water. We observed that the n-butanol fraction resulted in the highest hair regrowth activity. The n-butanol soluble fraction of P. frutescens extract (BFPE) was further separated using AB-8 macroporous resin and silica gel chromatography to obtain rosmarinic acid (RA), which demonstrated effective hair growth regeneration potential...
September 13, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28885585/hair-regenerative-mechanisms-of-red-ginseng-oil-and-its-major-components-in-the-testosterone-induced-delay-of-anagen-entry-in-c57bl-6-mice
#15
Van-Long Truong, Min Ji Bak, Changook Lee, Mira Jun, Woo-Sik Jeong
Hair loss (alopecia) is a universal problem for numerous people in the world. The present study was conducted to investigate the effects of red ginseng oil (RGO) and its major components on hair re-growth using testosterone (TES)-induced delay of anagen entry in C57BL/6 mice and their mechanisms of action. Seven-week-old C57BL/6 mice were daily treated with TES for 1 h prior to topical application of 10% RGO, 1% linoleic acid (LA), 1% β-sitosterol (SITOS), or 1% bicyclo(10.1.0)tridec-1-ene (BICYCLO) once a day for 28 days...
September 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28856798/digit-ratio-2d-4d-is-a-possible-indicator-for-androgenetic-alopecia-in-males
#16
Mehmet Unal
BACKGROUND: Androgenetic alopecia (AGA) is the most common hair loss. The 2D:4D digit ratio refers to the ratio of the length of the second finger to that of the fourth finger and is thought as a marker of prenatal androgen exposure. OBJECTIVES: There are many studies which have examined the relationship between 2D:4D ratio and some other diseases. In this study, we evaluated the relationship between digit ratio 2D:4D and AGA. METHODS: The study group was composed of a male with AGA and healthy controls...
August 29, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28852294/a-spilt-head-study-of-efficacy-of-placebo-versus-platelet-rich-plasma-injections-in-the-treatment-of-androgenic-alopecia
#17
Dilip Kachhawa, Gauri Vats, Durgesh Sonare, Pankaj Rao, Sandeep Khuraiya, Rohit Kataiya
BACKGROUND: Platelet-rich plasma (PRP) is an autologous concentration of human platelets contained in a small volume of plasma with haemostatic and tissue repairing effects. Being enriched by various growth factors, PRP has become the focus of attention in numerous fields of medicine. Androgenic alopecia (AGA) is a common chronic hair loss disorder, characterised by progressive hair loss. Despite the therapeutic options available, there is low patient compliance and satisfaction rate...
April 2017: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/28816743/elastic-staining-in-differentiating-between-follicular-streamers-and-follicular-scars-in-horizontal-scalp-biopsy-sections
#18
Timothy Tan, Joan Guitart, Pedram Gerami, Pedram Yazdan
BACKGROUND: Accurate identification of follicular streamers versus follicular scars on horizontal scalp biopsy sections is important to differentiate between cicatricial and noncicatricial alopecias. However, distinguishing between them can be difficult especially in nonoptimal specimens. The utility of elastic Verhoeff-Van Gieson (EVG) stain in cicatricial alopecias has been described on vertical sections, but its evaluation on horizontal sections has not been performed. METHODS: Sixty-four cicatricial alopecias (25 lichen planopilaris, 29 central centrifugal cicatricial alopecias, and 10 discoid lupus erythematosus) and 53 noncicatricial alopecias (34 androgenic alopecia, 8 telogen effluvium, and 11 alopecia areata) were identified, and EVG staining was performed on horizontal sections...
August 9, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28815175/platelet-rich-plasma-an-elixir-for-treatment-of-alopecia-personal-experience-on-117-patients-with-review-of-literature
#19
REVIEW
Suruchi Garg, Shweta Manchanda
Platelet-rich plasma (PRP) has emerged as a new treatment modality in regenerative plastic surgery and dermatology. PRP is a simple, cost-effective and feasible treatment option with high patient satisfaction for hair loss and can be regarded as a valuable adjuvant treatment modality for androgenic alopecia and other types of non-scarring alopecias. Authors have proposed a hair model termed "Golden anchorage with 'molecular locking' of ectodermal and mesenchymal components for survival and integrity of hair follicle (HF)" in this article...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28812164/efficacy-of-fractional-lasers-in-treating-alopecia-a-literature-review
#20
Marina Perper, Adam S Aldahan, Rachel A Fayne, Christopher P Emerson, Keyvan Nouri
Hair loss stemming from different types of alopecia, such as androgenic alopecia and alopecia areata, negatively affects over half the population and, in many circumstances, causes serious psychosocial distress. Current treatment options for alopecia, such as minoxidil, anthralin, and intralesional corticosteroids, vary efficacy and side effect profiles. It is known that low-level laser/light therapies (LLLT), or photobiomodulations, such as the US FDA-cleared HairMax Lasercomb®, He-Ne laser, and excimer laser, are relatively affordable, user-friendly, safe, and effective forms of treatment for hair loss...
November 2017: Lasers in Medical Science
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