Okko Alitalo, Gemma González-Hernández, Marko Rosenholm, Piia Kohtala, Nobuaki Matsui, Heidi Kaastrup Müller, Wiebke Theilmann, Anders Klein, Olli Kärkkäinen, Stanislav Rozov, Tomi Rantamäki, Samuel Kohtala
Many mechanisms have been proposed to explain acute antidepressant drug-induced activation of TrkB neurotrophin receptors, but several questions remain. In a series of pharmacological experiments, we observed that TrkB activation induced by antidepressants and several other drugs correlated with sedation, and most importantly, coinciding hypothermia. Untargeted metabolomics of pharmacologically dissimilar TrkB activating treatments revealed effects on shared bioenergetic targets involved in adenosine triphosphate (ATP) breakdown and synthesis, demonstrating a common perturbation in metabolic activity...
August 8, 2023: ACS Chemical Neuroscience