keyword
MENU ▼
Read by QxMD icon Read
search

Adenosine sleep

keyword
https://www.readbyqxmd.com/read/29692371/obstructive-sleep-apnea-affecting-platelet-reactivity-in-patients-undergoing-percutaneous-coronary-intervention
#1
Xiao-Min Jiang, Xue-Song Qian, Xiao-Fei Gao, Zhen Ge, Nai-Liang Tian, Jing Kan, Jun-Jie Zhang
Background: The relationship between obstructive sleep apnea (OSA) and platelet reactivity in patients undergoing percutaneous coronary intervention (PCI) has not been defined. The present prospective, single-center study explored the relationship between platelet reactivity and OSA in patients with PCI. Methods: A total of 242 patients were finally included in the study. OSA was screened overnight by polysomnography. Platelet reactivity was assessed with a sequential platelet counting method, and the platelet maximum aggregation ratio (MAR) and average aggregation ratio were calculated...
May 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29680437/treatment-of-restless-legs-syndrome-willis-ekbom-disease-with-the-non-selective-ent1-ent2-inhibitor-dipyridamole-testing-the-adenosine-hypothesis
#2
Diego Garcia-Borreguero, Xavier Guitart, Celia Garcia Malo, Irene Cano-Pumarega, Juan José Granizo, Sergi Ferré
OBJECTIVES: Recent animal models of restless legs syndrome (RLS) suggest that brain iron deficiency is associated with a hypoadenosinergic state, with downregulation of adenosine A1 receptors (A1R) in the striatum and cortex. We hypothesized that an increase in extracellular adenosine induced by inhibitors of adenosine transporters, such as the non-selective ENT1/ENT2 inhibitor dipyridamole, would result in an improvement in RLS symptoms. METHODS: In a prospective two-month open-label, non-placebo controlled clinical trial, 15 untreated idiopathic RLS patients began treatment with 100 mg dipyridamole (with uptitration to 400 mg if necessary)...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29649498/the-wakefulness-promoting-drug-modafinil-causes-adenosine-receptor-mediated-upregulation-of-receptor-activator-of-nuclear-factor-%C3%AE%C2%BAb-ligand-in-osteoblasts-negative-impact-of-the-drug-on-peak-bone-accrual-in-rats
#3
Shyamsundar Pal China, Subhashis Pal, Sourav Chattopadhyay, Konica Porwal, Monika Mittal, Sabyasachi Sanyal, Naibedya Chattopadhyay
Modafinil is primarily prescribed for treatment of narcolepsy and other sleep-associated disorders. However, its off-prescription use as a cognition enhancer increased considerably, specially among youths. Given its increasing use in young adults the effect of modafinil on peak bone accrual is an important issue but has never been investigated. Modafinil treatment to young male rats caused trabecular and cortical bone loss in tibia and femur, and reduction in biomechanical strength. Co-treatment of modafinil with alendronate (a drug that suppresses bone resorption) reversed the trabecular bone loss but failed to prevent cortical loss...
April 9, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29616880/is-adenosine-action-common-ground-for-nrem-sleep-torpor-and-other-hypometabolic-states
#4
Alessandro Silvani, Matteo Cerri, Giovanna Zoccoli, Steven J Swoap
This review compares two states that lower energy expenditure: non-rapid eye movement (NREM) sleep and torpor. Knowledge on mechanisms common to these states, and particularly on the role of adenosine in NREM sleep, may ultimately open the possibility of inducing a synthetic torpor-like state in humans for medical applications and long-term space travel. To achieve this goal, it will be important, in perspective, to extend the study to other hypometabolic states, which, unlike torpor, can also be experienced by humans...
May 1, 2018: Physiology
https://www.readbyqxmd.com/read/29615922/sensory-processing-and-integration-at-the-carotid-body-tripartite-synapse-neurotransmitter-functions-and-effects-of-chronic-hypoxia
#5
REVIEW
Erin M Leonard, Shaima Salman, Colin A Nurse
Maintenance of homeostasis in the respiratory and cardiovascular systems depends on reflexes that are initiated at specialized peripheral chemoreceptors that sense changes in the chemical composition of arterial blood. In mammals, the bilaterally-paired carotid bodies (CBs) are the main peripheral chemoreceptor organs that are richly vascularized and are strategically located at the carotid bifurcation. The CBs contribute to the maintenance of O2 , CO2 /H+ , and glucose homeostasis and have attracted much clinical interest because hyperactivity in these organs is associated with several pathophysiological conditions including sleep apnea, obstructive lung disease, heart failure, hypertension, and diabetes...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29614375/a-1-adenosine-receptors-in-the-striatum-play-a-role-in-the-impairment-caused-by-sleep-deprivation-through-downregulation-of-the-pka-pathway
#6
S L B Oliveira, M G M Oliveira, D C Hipolide
Sleep deprivation is known to affect memory formation, but how it interacts with different memory systems is not completely understood. Adenosine, a homeostatic regulator of sleep that has an increased extracellular concentration during sleep deprivation, is one of the neuromodulators that may be involved in this interaction. The A1 adenosine receptor is involved in both sleep regulation and memory formation. Among other pathways, the A1 receptor decreases cAMP levels in the cytosol and thus also regulates protein kinase A (PKA) and exchange protein activated by cAMP (EPAC) activity...
March 31, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29568240/differential-impact-of-diabetes-mellitus-on-antiplatelet-effects-of-prasugrel-and-clopidogrel
#7
Satoshi Niijima, Tsukasa Ohmori, Kazuomi Kario
Background: Although prasugrel exerts stronger antiplatelet effects compared with clopidogrel, the factors affecting platelet reactivity under prasugrel have not been fully determined. This study aimed to find the novel mechanistic differences between two thienopyridines and identify the factor that influence platelet reactivity to each drug. Methods: Forty patients with stable angina who underwent elective percutaneous coronary intervention were randomly assigned to receive either prasugrel (20 mg) or clopidogrel (300 mg) as a loading dose...
2018: Thrombosis Journal
https://www.readbyqxmd.com/read/29514871/interindividual-differences-in-caffeine-metabolism-and-factors-driving-caffeine-consumption
#8
REVIEW
Astrid Nehlig
Most individuals adjust their caffeine intake according to the objective and subjective effects induced by the methylxanthine. However, to reach the desired effects, the quantity of caffeine consumed varies largely among individuals. It has been known for decades that the metabolism, clearance, and pharmacokinetics of caffeine is affected by many factors such as age, sex and hormones, liver disease, obesity, smoking, and diet. Caffeine also interacts with many medications. All these factors will be reviewed in the present document and discussed in light of the most recent data concerning the genetic variability affecting caffeine levels and effects at the pharmacokinetic and pharmacodynamic levels that both critically drive the level of caffeine consumption...
April 2018: Pharmacological Reviews
https://www.readbyqxmd.com/read/29476336/neuroanatomical-and-neurochemical-bases-of-vigilance-states
#9
Pierre-Hervé Luppi, Patrice Fort
In the present chapter, hypotheses on the mechanisms responsible for the genesis of the three vigilance states, namely, waking, non-rapid eye movement (non-REM) also called slow-wave sleep (SWS), and REM sleep also called paradoxical sleep (PS), are presented. A huge number of studies first indicate that waking is induced by the activation of multiple waking systems, including the serotonergic, noradrenergic, cholinergic, and hypocretin systems. At the onset of sleep, the SWS-active neurons would be activated by the circadian clock localized in the suprachiasmatic nucleus and a hypnogenic factor, adenosine, which progressively accumulates in the brain during waking...
February 24, 2018: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/29467662/purinergic-signaling-in-neuron-astrocyte-interactions-circadian-rhythms-and-alcohol-use-disorder
#10
REVIEW
Daniel Lindberg, Lindsey Andres-Beck, Yun-Fang Jia, Seungwoo Kang, Doo-Sup Choi
Alcohol use disorder (AUD) is a debilitating condition marked by cyclic patterns of craving, use, and withdrawal. These pathological behaviors are mediated by multiple neurotransmitter systems utilizing glutamate, GABA, dopamine, ATP, and adenosine. In particular, purines such as ATP and adenosine have been demonstrated to alter the phase and function of the circadian clock and are reciprocally regulated by the clock itself. Importantly, chronic ethanol intake has been demonstrated to disrupt the molecular circadian clock and is associated with altered circadian patterns of activity and sleep...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29428169/effectiveness-of-a-combination-denture-cleaning-method-versus-a-mechanical-method-comparison-of-denture-cleanliness-patient-satisfaction-and-oral-health-related-quality-of-life
#11
Yuya Baba, Yusuke Sato, Gaku Owada, Shunsuke Minakuchi
PURPOSE: Effective denture plaque control is necessary in elderly individuals to prevent oral and systemic diseases. However, comparative studies of denture cleaning methods are limited, especially those investigating patient satisfaction. The present study aimed to evaluate effectiveness of a mechanical denture cleaning method versus a combination of mechanical and chemical methods in terms of denture cleanliness, patient satisfaction, and oral health-related quality of life (OHRQoL)...
February 7, 2018: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/29409952/adenosine-has-two-faces-regionally-dichotomous-adenosine-tone-in-a-model-of-epilepsy-with-comorbid-sleep-disorders
#12
Ted J Warren, Timothy A Simeone, D David Smith, Ryan Grove, Jiri Adamec, Kaeli K Samson, Harrison M Roundtree, Deepak Madhavan, Kristina A Simeone
OBJECTIVE: Adenosine participates in maintaining the excitatory/inhibitory balance in neuronal circuits. Studies indicate that adenosine levels in the cortex and hippocampus increase and exert sleep pressure in sleep-deprived and control animals, whereas in epilepsy reduced adenosine tone promotes hyperexcitability. To date, the role of adenosine in pathological conditions that result in both seizures and sleep disorders is unknown. Here, we determined adenosine tone in sleep and seizure regulating brain regions of Kv 1...
June 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29406892/could-istradefylline-be-a-treatment-option-for-postural-abnormalities-in-mid-stage-parkinson-s-disease
#13
Keisuke Suzuki, Tomoyuki Miyamoto, Masayuki Miyamoto, Tomoyuki Uchiyama, Koichi Hirata
BASEGROUND: Postural abnormalities are refractory complications observed in mid- to late-stage Parkinson's disease (PD). METHODS: We analyzed the effects of istradefylline, a selective adenosine A2A receptor antagonist, on posture in 21 levodopa-treated PD patients from the subanalysis of a three-month open-label study. RESULTS: The subitem score of posture (3.13) on the Movement Disorder Society revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) part III significantly improved following istradefylline treatment (baseline, 1...
February 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29380238/activating-adenosine-a1-receptor-accelerates-pc12-cell-injury-via-adora1-pkc-katp-pathway-after-intermittent-hypoxia-exposure
#14
Hong-Fang Mei, Neha Poonit, Yi-Chun Zhang, Chu-Yuan Ye, Hui-Lin Cai, Chen-Yi Yu, Yong-Hai Zhou, Bei-Bei Wu, Jun Cai, Xiao-Hong Cai
Obstructive sleep apnea hypopnea syndrome (OSAHS) is associated with the neurocognitive deficits as a result of the neuronal cell injury. Previous studies have shown that adenosine A1 receptor (ADORA1) played an important role against hypoxia exposure, such as controlling the metabolic recovery in rat hippocampal slices and increasing the resistance in the combined effects of hypoxia and hypercapnia. However, little is known about whether ADORA1 takes part in the course of neuronal cell injury after intermittent hypoxia exposure which was the main pathological characteristic of OSAHS...
January 29, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29369596/melatonin-with-adenosine-solubilized-in-water-and-stabilized-with-glycine-for-oncological-treatment-technical-preparation-effectivity-and-clinical-findings
#15
Giuseppe Di Bella, Luciano Gualano, Luigi Di Bella
Melatonin has shown the potential to inhibit growth of different tumors, both in vitro and in vivo. There is clear evidence that the administration of melatonin alone or in combination with chemo and radiotherapy in cancer patients with advanced solid tumors has been associated with improved outcomes of tumor regression and survival. Moreover, chemotherapy has been shown to be better tolerated in patients treated with melatonin. However, there are different ways of preparation and administration of melatonin to the patient...
December 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29261550/misaligned-feeding-may-aggravate-pain-by-disruption-of-sleep-awake-rhythm
#16
Fangxia Xu, Xin Zhao, Huan Liu, Xueming Shao, Shuaishuai Chu, Xiangdan Gong, Zhengliang Ma, Xiaoping Gu
BACKGROUND: Increasing evidence suggests that patients with eating disorders are more likely to develop chronic pain. A misaligned diet has been reported to disrupt the sleep-awake rhythms. Combined with our previous investigation on circadian pain, we aimed to investigate the role of misaligned diet in the pain sensitivity and the underlying mechanisms. METHODS: Two-month-old C57BL/6J male mice were administered chronic constriction injury (CCI) surgery to establish neuropathic pain models...
December 19, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29189169/computer-aided-drug-design-applied-to-parkinson-targets
#17
Hamilton M Ishiki, Jose Maria Barbosa Filho, Marcelo S da Silva, Marcus T Scotti, Luciana Scotti
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by debilitating motor deficits, as well as autonomic problems, cognitive declines, changes in affect and sleep disturbances. Although the scientific community has performed great efforts in the study of PD, and from the most diverse points of view, the disease remains incurable. The exact mechanism underlying its progression is unclear, but oxidative stress, mitochondrial dysfunction and inflammation are thought to play major roles in the etiology...
November 28, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/29154957/the-yin-yang-of-inflammatory-status-blood-brain-barrier-regulation-during-sleep
#18
G Hurtado-Alvarado, E Becerril-Villanueva, A Contis-Montes de Oca, E Domínguez-Salazar, N Salinas-Jazmín, S M Pérez-Tapia, L Pavon, J Velázquez-Moctezuma, B Gómez-González
Sleep loss induces a low-grade inflammatory status characterized by a subtle but sustained increase of pro-inflammatory mediators, which are key regulators of blood-brain barrier function. To investigate the influence of inflammatory status on blood-brain barrier dysfunction induced by sleep restriction we performed an experiment using two strains of mice with different immunological backgrounds, C57BL/6 mice that have a predominant pro-inflammatory response and BALB/c mice that have a predominant anti-inflammatory response...
March 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29149028/changes-of-cerebral-and-or-peripheral-adenosine-a%C3%A2-receptor-and-igf-i-concentrations-under-extended-sleep-duration-in-rats
#19
Mounir Chennaoui, Pierrick J Arnal, Rodolphe Dorey, Fabien Sauvet, Sylvain Ciret, Thierry Gallopin, Damien Leger, Catherine Drogou, Danielle Gomez-Merino
Extended sleep improves sustained attention and reduces sleep pressure in humans. Downregulation of adenosine A₁ receptor (A₁R) and modulation of the neurotrophic factor insulin growth factor-1 (IGF-I) in brain structures controlling attentional capacities could be involved. In the frontal cortex and hippocampus of rats, we measured adenosine A₁R and IGF-I protein concentrations after photoperiod-induced sleep extension. Two groups of twelve rats were adapted over 14 days to a habitual (CON) 12:12 light-dark (LD) schedule and an extended (EXT) 16:8 LD schedule...
November 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29120660/-adenosine-a-mediator-with-multisystemic-effects-or-a-hormone
#20
Zora Lazúrová, Peter Mitro
Adenosine is a nucleoside regulating many physiological and pathological processes in human organism. It is produced by almost all cells and is metabolised by adenosinedeaminase enzyme. Effect of adenosine is mediated by three types of adenosine receptors. Adenosinergic system significantly influences function of cardiovascular system, furthemore it plays a key role in sleep homeostasis, in regulation of bone metabolism and activation of immune system. Adenosine mediates effect of various hormones, but also adenosine itself has its own autocrine, paracrine and systemic effects...
December 0: Vnitr̆ní Lékar̆ství
keyword
keyword
20657
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"