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Adenosine sleep

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https://www.readbyqxmd.com/read/27893847/a2a-adenosine-receptor-antagonism-reverts-the-blood-brain-barrier-dysfunction-induced-by-sleep-restriction
#1
Gabriela Hurtado-Alvarado, Emilio Domínguez-Salazar, Javier Velázquez-Moctezuma, Beatriz Gómez-González
Chronic sleep restriction induces blood-brain barrier disruption and increases pro-inflammatory mediators in rodents. Those inflammatory mediators may modulate the blood-brain barrier and constitute a link between sleep loss and blood-brain barrier physiology. We propose that adenosine action on its A2A receptor may be modulating the blood-brain barrier dynamics in sleep-restricted rats. We administrated a selective A2A adenosine receptor antagonist (SCH58261) in sleep-restricted rats at the 10th day of sleep restriction and evaluated the blood-brain barrier permeability to dextrans coupled to fluorescein (FITC-dextrans) and Evans blue...
2016: PloS One
https://www.readbyqxmd.com/read/27784808/the-role-of-adenosine-in-the-maturation-of-sleep-homeostasis-in-rats
#2
Irma Gvilia, Natalia Suntsova, Andrey Kostin, Anna Kalinchuk, Dennis McGinty, Radhika Basheer, Ronald Szymusiak
Sleep homeostasis in rats undergoes significant maturational changes during post-weaning development, but underlying mechanisms of this process are unknown. In the present study we tested the hypothesis that the maturation of sleep is related to the functional emergence of adenosine (AD) signaling in the brain. We assessed post-weaning changes in (1) wake-related elevation of extracellular AD in the basal forebrain (BF) and adjacent lateral preoptic area (LPO) and (2) the responsiveness of median preoptic nucleus (MnPO) sleep-active cells to increasing homeostatic sleep drive...
October 26, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27769744/sleep-wakefulness-cycle-and-behavior-in-pannexin1-knockout-mice
#3
V M Kovalzon, L S Moiseenko, A V Ambaryan, S Kurtenbach, V I Shestopalov, Y V Panchin
Pannexins are membrane channel proteins that play a role in a number of critical biological processes (Panchin et al., 2000; Shestopalov, Panchin, 2008). Among other cellular functions, pannexin hemichannels serve as purine nucleoside conduits providing ATP efflux into the extracellular space (Dahl, 2015), where it is rapidly degraded to adenosine. Pannexin1 (Panx1) is abundantly expressed in the brain and has been shown to contribute to adenosine signaling in nervous system tissues (Prochnow et al., 2012)...
October 18, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27746343/revealing-the-role-of-the-endocannabinoid-system-modulators-sr141716a-urb597-and-vdm-11-in-sleep-homeostasis
#4
Eric Murillo-Rodríguez, Sergio Machado, Nuno Barbosa Rocha, Henning Budde, Ti-Fei Yuan, Oscar Arias-Carrión
The endocannabinoid system comprises receptors (CB1 and CB2 cannabinoid receptors), enzymes (Fatty Acid Amide Hydrolase [FAAH], which synthesizes the endocannabinoid anandamide), as well as the anandamide membrane transporter (AMT). Importantly, previous experiments have demonstrated that the endocannabinoid system modulates multiple neurobiological functions, including sleep. For instance, SR141716A (the CB1 cannabinoid receptor antagonist) as well as URB597 (the FAAH inhibitor) increase waking in rats whereas VDM-11 (the blocker of the AMT) enhances sleep in rodents...
December 17, 2016: Neuroscience
https://www.readbyqxmd.com/read/27707719/p2x7-receptors-in-body-temperature-locomotor-activity-and-brain-mrna-and-lncrna-responses-to-sleep-deprivation
#5
Christopher J Davis, Ping Taishi, Kimberly A Honn, John N Koberstein, James M Krueger
The ionotropic purine type 2X7 receptor (P2X7R) is a nonspecific cation channel implicated in sleep regulation and brain cytokine release. Many endogenous rhythms covary with sleep, including locomotor activity and core body temperature. Furthermore, brain-hypothalamic cytokines and purines play a role in the regulation of these physiological parameters as well as sleep. We hypothesized that these parameters are also affected by the absence of the P2X7 receptor. Herein, we determine spontaneous expression of body temperature and locomotor activity in wild-type (WT) and P2X7R knockout (KO) mice and how they are affected by sleep deprivation (SD)...
December 1, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27646482/evidence-that-activation-of-nuclear-peroxisome-proliferator-activated-receptor-alpha-ppar%C3%AE-modulates-sleep-homeostasis-in-rats
#6
Eric Murillo-Rodríguez, Khalil Guzmán, Gloria Arankowsky-Sandoval, Mireille Salas-Crisóstomo, Ramsés Jiménez-Moreno, Oscar Arias-Carrión
The peroxisome proliferator-activated receptor alpha (PPARα) is a member of the nuclear receptor superfamily that has been suggested as a modulator of several physiological functions. The PPARα recognizes as an endogenous ligand the anorexic lipid mediator oleoylethanolamide (OEA) which displays wake-inducing properties. Despite that recent evidence indicates that activation of PPARα by synthetic agonists such as Wy14643 enhances waking as well as the extracellular contents of wake-related neurotransmitters, the role of PPARα in sleep recovery after prolonged waking has not been fully described...
September 16, 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/27634786/sleep-and-behavior-in-cross-fostering-rats-developmental-and-sex-aspects
#7
Olena Santangeli, Henna Lehtikuja, Eeva Palomäki, Henna-Kaisa Wigren, Tiina Paunio, Tarja Porkka-Heiskanen
STUDY OBJECTIVE: Adverse early-life events induce behavioral psychopathologies and sleep changes in adulthood. In order to understand the molecular level mechanisms by which the maltreatment modifies sleep, valid animal models are needed. Changing pups between mothers at early age (cross-fostering) may satisfyingly model adverse events in human childhood. METHODS: Cross-fostering (CF) was used to model mild early-life stress in male and female Wistar rats. Behavior and BDNF gene expression in the basal forebrain (BF), cortex, and hypothalamus were assessed during adolescence and adulthood...
September 9, 2016: Sleep
https://www.readbyqxmd.com/read/27623393/adenosine-a1-receptor-antagonist-mitigates-deleterious-effects-of-sleep-deprivation-on-adult-neurogenesis-and-spatial-reference-memory-in-rats
#8
G Chauhan, K Ray, S Sahu, K Roy, V Jain, M Wadhwa, U Panjwani, K Kishore, S B Singh
Sleep deprivation (SD) upsurges intracellular levels of adenosine, impairs adult neuronal cell proliferation (NCP) and cognition while caffeine, a non-selective adenosine A1 receptor (A1R) antagonist improves cognition and adult NCP during SD. We examined the selective antagonistic effects of adenosine A1R using 8-cyclopentyl-1,3-dimethylxanthine (8-CPT) on impairment of spatial reference memory and adult NCP during 48h SD. Adult male Sprague Dawley rats were sleep deprived for 48h, using an automatic cage vibrating stimulus based on animal activity...
September 10, 2016: Neuroscience
https://www.readbyqxmd.com/read/27612937/a-review-of-caffeine-s-effects-on-cognitive-physical-and-occupational-performance
#9
REVIEW
Tom M McLellan, John A Caldwell, Harris R Lieberman
Caffeine is consumed by over 80% of U.S. adults. This review examines the effects caffeine has on cognitive and physical function, since most real-world activities require complex decision making, motor processing and movement. Caffeine exerts its effects by blocking adenosine receptors. Following low (∼40mg or ∼0.5mgkg(-1)) to moderate (∼300mg or 4mgkg(-1)) caffeine doses, alertness, vigilance, attention, reaction time and attention improve, but less consistent effects are observed on memory and higher-order executive function, such as judgment and decision making...
December 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27600688/adenosine-receptors-as-markers-of-brain-iron-deficiency-implications-for-restless-legs-syndrome
#10
César Quiroz, Seema Gulyani, Wan Ruiqian, Jordi Bonaventura, Roy Cutler, Virginia Pearson, Richard P Allen, Christopher J Earley, Mark P Mattson, Sergi Ferré
Deficits of sensorimotor integration with periodic limb movements during sleep (PLMS) and hyperarousal and sleep disturbances in Restless Legs Syndrome (RLS) constitute two pathophysiologically distinct but interrelated clinical phenomena, which seem to depend mostly on alterations in dopaminergic and glutamatergic neurotransmission, respectively. Brain iron deficiency is considered as a main pathogenetic mechanism in RLS. Rodents with brain iron deficiency represent a valuable pathophysiological model of RLS, although they do not display motor disturbances...
December 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27571159/sudden-unexpected-death-in-epilepsy-epidemiology-mechanisms-and-prevention
#11
REVIEW
Orrin Devinsky, Dale C Hesdorffer, David J Thurman, Samden Lhatoo, George Richerson
Sudden unexpected death in epilepsy (SUDEP) can affect individuals of any age, but is most common in younger adults (aged 20-45 years). Generalised tonic-clonic seizures are the greatest risk factor for SUDEP; most often, SUDEP occurs after this type of seizure in bed during sleep hours and the person is found in a prone position. SUDEP excludes other forms of seizure-related sudden death that might be mechanistically related (eg, death after single febrile, unprovoked seizures, or status epilepticus). Typically, postictal apnoea and bradycardia progress to asystole and death...
September 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27522071/adenosine-differentially-modulates-synaptic-transmission-of-excitatory-and-inhibitory-microcircuits-in-layer-4-of-rat-barrel-cortex
#12
Guanxiao Qi, Karlijn van Aerde, Ted Abel, Dirk Feldmeyer
Adenosine is considered to be a key regulator of sleep homeostasis by promoting slow-wave sleep through inhibition of the brain's arousal centers. However, little is known about the effect of adenosine on neuronal network activity at the cellular level in the neocortex. Here, we show that adenosine differentially modulates synaptic transmission between different types of neurons in cortical layer 4 (L4) through activation of pre- and/or postsynaptically located adenosine A1 receptors. In recurrent excitatory connections between L4 spiny neurons, adenosine suppresses synaptic transmission through activation of both pre- and postsynaptic A1 receptors...
August 13, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27485749/adenosine-a2a-receptors-in-the-olfactory-bulb-suppress-rapid-eye-movement-sleep-in-rodents
#13
Yi-Qun Wang, Rui Li, Dian-Ru Wang, Yoan Cherasse, Ze Zhang, Meng-Qi Zhang, Oriana Lavielle, Kristopher McEown, Serge N Schiffmann, Alban de Kerchove d'Exaerde, Wei-Min Qu, Michael Lazarus, Zhi-Li Huang
Rapid eye movement (REM) sleep behavior disorder in humans is often accompanied by a reduced ability to smell and detect odors, and olfactory bulbectomized rats exhibit increased REM sleep, suggesting that the olfactory bulb (OB) is involved in REM-sleep regulation. However, the molecular mechanism of REM-sleep regulation by the OB is unknown. Adenosine promotes sleep and its A2A receptors (A2AR) are expressed in the OB. We hypothesized that A2AR in the OB regulate REM sleep. Bilateral microinjections of the A2AR antagonist SCH58261 into the rat OB increased REM sleep, whereas microinjections of the A2AR agonist CGS21680 decreased REM sleep...
August 2, 2016: Brain Structure & Function
https://www.readbyqxmd.com/read/27338238/oral-administration-of-japanese-sake-yeast-saccharomyces-cerevisiae-sake-promotes-non-rapid-eye-movement-sleep-in-mice-via-adenosine-a2a-receptors
#14
Yoshitaka Nakamura, Tatsuyuki Midorikawa, Noriyuki Monoi, Eriko Kimura, Ayumi Murata-Matsuno, Tomomi Sano, Kengo Oka, Toshihiro Sugafuji, Akira Uchiyama, Michiaki Murakoshi, Keikichi Sugiyama, Hoyoku Nishino, Yoshihiro Urade
We have demonstrated previously that Japanese sake yeast improves sleep quality in humans. In the present study, we examined the molecular mechanisms of sake yeast to induce sleep by monitoring locomotor activity, electromyogram and electroencephalogram in mice. Oral administration of Japanese sake yeast (100, 200, and 300 mg kg(-1) ) decreased the locomotor activity by 18, 46 and 59% and increased the amount of non-rapid eye movement (NREM) sleep by 1.5-, 2.3- and 2.4-fold (to 37 ± 6, 57 ± 8, and 60 ± 4 min from 25 ± 6 min in the vehicle-administered group, respectively) in a dose-dependent manner for 4 h after oral administration...
June 23, 2016: Journal of Sleep Research
https://www.readbyqxmd.com/read/27297283/getting-personal-endogenous-adenosine-receptor-signaling-in-lymphoblastoid-cell-lines
#15
J M Hillger, C Diehl, E van Spronsen, D I Boomsma, P E Slagboom, L H Heitman, A P IJzerman
Genetic differences between individuals that affect drug action form a challenge in drug therapy. Many drugs target G protein-coupled receptors (GPCRs), and a number of receptor variants have been noted to impact drug efficacy. This, however, has never been addressed in a systematic way, and, hence, we studied real-life genetic variation of receptor function in personalized cell lines. As a showcase we studied adenosine A2A receptor (A2AR) signaling in lymphoblastoid cell lines (LCLs) derived from a family of four from the Netherlands Twin Register (NTR), using a non-invasive label-free cellular assay...
September 1, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27242540/nadph-oxidase-derived-ros-induced-by-chronic-intermittent-hypoxia-mediates-hypersensitivity-of-lung-vagal-c-fibers-in-rats
#16
Chang-Huan Yang, Wei-Ling Zhuang, Yan-Jhih Shen, Ching Jung Lai, Yu Ru Kou
Obstructive sleep apnea (OSA), manifested by exposure to chronic intermittent hypoxia (CIH) and excess production of reactive oxygen species (ROS) in the airways, is associated with hyperreactive airway diseases. ROS, particularly when created by NADPH oxidase, are known to sensitize lung vagal C fibers (LVCFs), which may contribute to airway hypersensitivity pathogenesis. We investigated whether CIH augments the reflex and afferent responses of LVCFs to chemical stimulants and the roles of ROS and NADPH oxidase in such airway hypersensitivity...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27096358/effect-of-cpap-withdrawal-on-myocardial-perfusion-in-osa-a-randomized-controlled-trial
#17
Esther I Schwarz, Christian Schlatzer, Julia Stehli, Philipp A Kaufmann, Konrad E Bloch, John R Stradling, Malcolm Kohler
BACKGROUND AND OBJECTIVE: Obstructive sleep apnoea (OSA) is highly prevalent and associated with an increased incidence of cardiovascular events. Endothelial dysfunction is the proposed causative mechanism. Continuous positive airway pressure (CPAP) is presumed to improve cardiovascular outcome in OSA. CPAP withdrawal was recently shown to lead to peripheral endothelial dysfunction. However, it is not known whether short-term CPAP withdrawal reduces myocardial perfusion in OSA. METHODS: In this double-blind randomized controlled study, 45 patients with moderate to severe OSA previously adherent to CPAP were assigned to either subtherapeutic or continuing therapeutic CPAP for 2 weeks...
August 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27085634/the-effects-of-creatine-supplementation-on-thermoregulation-and-physical-cognitive-performance-a-review-and-future-prospects
#18
REVIEW
R Twycross-Lewis, L P Kilduff, G Wang, Y P Pitsiladis
Creatine (Cr) is produced endogenously in the liver or obtained exogenously from foods, such as meat and fish. In the human body, 95 % of Cr is located in the cytoplasm of skeletal muscle either in a phosphorylated (PCr) or free form (Cr). PCr is essential for the immediate rephosphorylation of adenosine diphosphate to adenosine triphosphate. PCr is rapidly degraded at the onset of maximal exercise at a rate that results in muscle PCr reservoirs being substantially depleted. A well-established strategy followed to increase muscle total Cr content is to increase exogenous intake by supplementation with chemically pure synthetic Cr...
August 2016: Amino Acids
https://www.readbyqxmd.com/read/27036940/trypanosoma-brucei-methylthioadenosine-phosphorylase-protects-the-parasite-from-the-antitrypanosomal-effect-of-deoxyadenosine-implications-for-the-pharmacology-of-adenosine-antimetabolites
#19
Munender Vodnala, Farahnaz Ranjbarian, Anna Pavlova, Harry P de Koning, Anders Hofer
Trypanosoma brucei causes African sleeping sickness for which no vaccine exists and available treatments are of limited use due to their high toxicity or lack of efficacy. T. brucei cultivated in the presence of deoxyadenosine accumulates high levels of dATP in an adenosine kinase-dependent process and dies within a few hours. Here we show that T. brucei treated with 1 mm deoxyadenosine accumulates higher dATP levels than mammalian cells but that this effect diminishes quickly as the concentration of the deoxynucleoside decreases...
May 27, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27030757/an-adenosine-mediated-glial-neuronal-circuit-for-homeostatic-sleep
#20
Theresa E Bjorness, Nicholas Dale, Gabriel Mettlach, Alex Sonneborn, Bogachan Sahin, Allen A Fienberg, Masashi Yanagisawa, James A Bibb, Robert W Greene
UNLABELLED: Sleep homeostasis reflects a centrally mediated drive for sleep, which increases during waking and resolves during subsequent sleep. Here we demonstrate that mice deficient for glial adenosine kinase (AdK), the primary metabolizing enzyme for adenosine (Ado), exhibit enhanced expression of this homeostatic drive by three independent measures: (1) increased rebound of slow-wave activity; (2) increased consolidation of slow-wave sleep; and (3) increased time constant of slow-wave activity decay during an average slow-wave sleep episode, proposed and validated here as a new index for homeostatic sleep drive...
March 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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