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MiR-146

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https://www.readbyqxmd.com/read/27917303/mir-146a-is-upregulated-during-retinal-pigment-epithelium-rpe-choroid-aging-in-mice-and-represses-il-6-and-vegf-a-expression-in-rpe-cells
#1
Yi Hao, Qinbo Zhou, Jing Ma, Yun Zhao, Shusheng Wang
PURPOSE: MicroRNA-146a (miR-146a) has been proposed as a marker for age-associated inflammation, or "inflammaging", acting as a negative regulator of cellular senescence and pro-inflammatory signaling pathways. However, the regulation and function of miR-146 during ocular aging remains unclear. Here we propose that miR-146 is regulated during aging of the retina and choroid, and functions in retinal pigment epithelial (RPE) cells to regulate key genes involved in inflammation and angiogenesis...
June 2016: Journal of Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27893422/pttg1-regulated-by-mir-146-3p-promotes-bladder-cancer-migration-invasion-metastasis-and-growth
#2
Wei Xiang, Xinchao Wu, Chao Huang, Miao Wang, Xian Zhao, Gang Luo, Yawei Li, Guosong Jiang, Xingyuan Xiao, Fuqing Zeng
Pituitary tumor-transforming gene 1 (PTTG1) is identified as an oncogene, and overexpresses in many tumors. However, the role of PTTG1 in bladder cancer (BC) hasn't yet been characterized well. In this study, we showed the expression of PTTG1 mRNA and protein were both significantly increased in BC tissues and cells. The PTTG1 protein levels were positive correlated with increased tumor size, tumor-node-metastasis (TNM) stage, lymphatic invasion and distant metastasis of BC. PTTG1 knockdown dramatically suppressed the migration, invasion, metastasis and growth, and induced senescence and cell-cycle arrest at G0/G1 phase of BC cells...
November 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/27586203/mirna-expression-profiling-of-noninvasive-follicular-thyroid-neoplasms-with-papillary-like-nuclear-features-compared-with-adenomas-and-infiltrative-follicular-variants-of-papillary-thyroid-carcinomas
#3
Nicla Borrelli, Maria Denaro, Clara Ugolini, Anello Marcello Poma, Mario Miccoli, Paolo Vitti, Paolo Miccoli, Fulvio Basolo
Follicular variants of papillary thyroid carcinoma include encapsulated (with or without capsular/vascular invasion) and infiltrative forms, which have different clinical behaviors. The encapsulated forms that lack capsular invasion have an indolent clinical behavior that is similar to benign lesions; therefore, they were recently reclassified as 'noninvasive follicular thyroid neoplasms with papillary-like nuclear features' (NIFTPs). Because NIFTPs have nuclear features of papillary carcinomas, distinguishing between NIFTPs and infiltrative follicular variant of papillary thyroid carcinoma is almost impossible with cytological examination...
September 2, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27585977/micrornas-in-allergic-disease
#4
Eishika Dissanayake, Yuzaburo Inoue
PURPOSE OF REVIEW: MicroRNAs (miRNAs) are short, single-stranded, non-coding RNAs that are increasingly being recognized as important epigenetic regulators. They have been implicated in the pathogenesis of many diseases including cancer, cardiovascular diseases, connective tissue diseases, and neuromuscular disorders. RECENT FINDINGS: A few miRNAs have already been recognized as a core set of miRNAs important in allergic inflammation. These include let-7, miR-21, miR-142, and miR-146...
September 2016: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/27558530/pancreas-enriched-mirnas-are-altered-in-the-circulation-of-subjects-with-diabetes-a-pilot-cross-sectional-study
#5
Attila A Seyhan, Yury O Nunez Lopez, Hui Xie, Fanchao Yi, Clayton Mathews, Magdalena Pasarica, Richard E Pratley
The clinical presentation of diabetes sometimes overlaps, contributing to ambiguity in the diagnosis. Thus, circulating pancreatic islet-enriched microRNAs (miRNAs) might be useful biomarkers of β-cell injury/dysfunction that would allow more accurate subtyping of diabetes. We measured plasma levels of selected miRNAs in subjects with prediabetes (n = 12), type 2 diabetes (T2D, n = 31), latent autoimmune diabetes of adults (LADA, n = 6) and type 1 diabetes (T1D, n = 16) and compared them to levels in healthy control subjects (n = 27)...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27516962/traumatic-brain-injury-increases-levels-of-mir-21-in-extracellular-vesicles-implications-for-neuroinflammation
#6
Emily B Harrison, Colleen G Hochfelder, Benjamin G Lamberty, Brittney M Meays, Brenda M Morsey, Matthew L Kelso, Howard S Fox, Sowmya V Yelamanchili
Traumatic brain injury (TBI) is an important health concern and effective treatment strategies remain elusive. Understanding the complex multicellular response to TBI may provide new avenues for intervention. In the context of TBI, cell-cell communication is critical. One relatively unexplored form of cell-cell communication in TBI is extracellular vesicles (EVs). These membrane-bound vesicles can carry many different types of cargo between cells. Recently, miRNA in EVs have been shown to mediate neuroinflammation and neuronal injury...
August 2016: FEBS Open Bio
https://www.readbyqxmd.com/read/27497395/association-of-microrna-146-with-middle-ear-hyperplasia-in-pediatric-otitis-media
#7
Tina L Samuels, Justin Yan, Pawjai Khampang, Alexander MacKinnon, Wenzhou Hong, Nikki Johnston, Joseph E Kerschner
OBJECTIVE: Toll-like receptor signaling activated by bacterial otitis media pathogens in the middle ear has been shown to play a key role in OM susceptibility, pathogenesis and recovery. Recent studies implicate microRNA 146 (miR-146) in regulation of inflammation via negative feedback of toll-like receptor signaling (TLR) in a wide variety of tissues, however its involvement in otitis media is unknown. METHODS: Human middle ear epithelial cells were stimulated with proinflammatory cytokines, interleukin 1 beta or tumor necrosis factor alpha, for two to twenty-four hours...
September 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27494344/role-of-mir-146a-in-the-regulation-of-inflammation-in-an-in-vitro-model-of-graves-orbitopathy
#8
Sun Young Jang, Min Kyung Chae, Joon H Lee, Eun Jig Lee, Jin Sook Yoon
PURPOSE: To investigate the role of microRNA 146a (miR-146a) in the regulation of inflammation in an in vitro model of Graves' orbitopathy (GO). METHODS: The level of miR-146a expression in orbital adipose tissue was compared between GO and non-GO by quantitative real-time PCR (qPCR). The effects of interleukin 1β (IL-1β) on miR-146a expression were analyzed in orbital fibroblasts by qPCR. To investigate the molecular mechanism underlying IL-1β-induced miR-146a expression, the effects of inhibitors of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), mitogen-activated protein kinase/extracellular signal-regulated kinases (MEK)-1/2, c-Jun N-terminal kinases (JNK)-1/2, p38 MAP kinase, and phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) were analyzed...
August 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27431205/a-single-nucleotide-polymorphism-in-hsa%C3%A2-mir%C3%A2-146a-is-responsible-for-the-development-of-bronchial-hyperresponsiveness-in-response-to-intubation-during-general-anesthesia
#9
Yong Luan, Dongjiang Li, Lulu Gao, Sha Xie, Ling Pei
Bronchial hyperresponsiveness (BHR) is the most common clinical manifestation identified in asthmatic patients, and intubation is the major factor that stimulates the airway of patients receiving general anesthetic. In the present study, nitric oxide synthase 1 (NOS1) was identified as a target gene of micro (mi)R‑146a using in silico analysis and luciferase assay. Furthermore, the regulatory role of miR‑146a was demonstrated by the observation that the NOS1 expression level in pulmonary artery smooth muscle cells (PASMCs) transfected with miR‑146a mimics was significantly downregulated and the NOS1 expression level in PASMCs transfected with miR‑146a inhibitors was significantly upregulated...
September 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27345902/direct-peritoneal-resuscitation-alters-hepatic-mirna-expression-after-hemorrhagic-shock
#10
Jessica L Weaver, Paul J Matheson, Ryan T Hurt, Cynthia D Downard, Craig J McClain, R Neal Garrison, Jason W Smith
BACKGROUND: MicroRNAs (miRNAs) are small segments of noncoding RNA that regulate gene expression and protein function, and therefore are key regulators of cellular processes including those of the inflammatory cascade after hemorrhagic shock (HS). We have previously shown that direct peritoneal resuscitation (DPR), as an adjunct to traditional IV fluid resuscitation, improves visceral blood flow and reduces pro-inflammatory cytokines released during HS. The effects of DPR on hepatic miRNA (miR) expression patterns after resuscitated HS are not known...
July 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/27225664/cucurbitacin-e-potently-modulates-the-activity-of-encephalitogenic-cells
#11
Bojan Jevtić, Neda Djedović, Suzana Stanisavljević, Jovana Despotović, Djordje Miljković, Gordana Timotijević
Cucurbitacin E (CucE) is a highly oxidized steroid consisting of a tetracyclic triterpene. It is a member of a Cucurbitacin family of biomolecules that are predominantly found in Cucurbitaceae plants. CucE has already been identified as a potent anti-inflammatory compound. Here, its effects on CD4(+) T helper (Th) cells and macrophages, as the major encephalitogenic cells in the autoimmunity of the central nervous system, were investigated. Production of major pathogenic Th cell cytokines: interferon-gamma and interleukin-17 were inhibited under the influence of CucE...
June 22, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27212168/the-functional-analysis-of-micrornas-involved-in-nf-%C3%AE%C2%BAb-signaling
#12
Y Yang, J-K Wang
Nuclear factor kB (NF-kB) is a transcriptional factor that regulates a large number of genes that controls diverse biological functions, ranging from inflammation, cell proliferation and tumor development to learning and memory. MicroRNAs (miRNAs) are small non-coding RNA molecules involved in most aspects of physiological and pathological processes, including cancer, viral infections, inflammation and autoimmune diseases. miRNAs also play an important role in the regulation of NF-kB signaling pathway, some being inhibitory and others activating...
May 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27102525/altered-microrna-expression-and-pre-mrna-splicing-events-reveal-new-mechanisms-associated-with-early-stage-mycobacterium-avium-subspecies-paratuberculosis-infection
#13
Guanxiang Liang, Nilusha Malmuthuge, Yongjuan Guan, Yuwei Ren, Philip J Griebel, Le Luo Guan
The molecular regulatory mechanisms of host responses to Mycobacterium avium subsp. paratuberculosis (MAP) infection during the early subclinical stage are still not clear. In this study, surgically isolated ileal segments in newborn calves (n = 5) were used to establish in vivo MAP infection adjacent to an uninfected control intestinal compartment. RNA-Seq was used to profile the whole transcriptome (mRNAs) and the microRNAome (miRNAs) of ileal tissues collected at one-month post-infection. The most related function of the differentially expressed mRNAs between infected and uninfected tissues was "proliferation of endothelial cells", indicating that MAP infection may lead to the over-proliferation of endothelial cells...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27011326/family-of-microrna-146-regulates-rar%C3%AE-in-papillary-thyroid-carcinoma
#14
Agnieszka Anna Czajka, Anna Wójcicka, Anna Kubiak, Marta Kotlarek, Elwira Bakuła-Zalewska, Łukasz Koperski, Wiesław Wiechno, Krystian Jażdżewski
Retinoic acid is a promising tool in adjuvant cancer therapies, including refractory thyroid cancer, and its biological role is mediated by the retinoic acid receptor beta (RARβ). However, expression of RARβ is lowered in papillary thyroid carcinoma (PTC), contributing to promotion of tumor growth and inefficiency of retinoic acid and radioactive iodine treatment. The causes of aberrant RARB expression are largely unknown. We hypothesized that the culpable mechanisms include the action of microRNAs from the miR-146 family, previously identified as significantly upregulated in PTC tumors...
2016: PloS One
https://www.readbyqxmd.com/read/26996343/mir-146-and-mir-125-in-the-regulation-of-innate-immunity-and-inflammation
#15
Hye-Mi Lee, Tae Sung Kim, Eun-Kyeong Jo
Innate immune responses are primary, relatively limited, and specific responses to numerous pathogens and toxic molecules. Protein expression involved in these innate responses must be tightly regulated at both transcriptional level and post-transcriptional level to avoid the development of excessive inflammation that can be potentially harmful to the host. MicroRNAs are small noncoding RNAs (~22 nucleotides [nts]) that participate in the regulation of numerous physiological responses by targeting specific messenger RNAs to suppress their translation...
June 2016: BMB Reports
https://www.readbyqxmd.com/read/26965144/mir-146a-exerts-differential-effects-on-melanoma-growth-and-metastatization
#16
Monica Raimo, Francesca Orso, Elena Grassi, Daniela Cimino, Elisa Penna, Cristiano De Pitta, Michael B Stadler, Luca Primo, Enzo Calautti, Pietro Quaglino, Paolo Provero, Daniela Taverna
: Malignant melanoma is the most aggressive form of skin cancer therefore it is crucial to disclose its underlying molecular mechanisms. MicroRNAs (miRs) are small endogenous non-coding RNAs able to post-transcriptionally down-regulate the expression of direct target genes. Using a melanoma progression model, miR-146a was identified as a key double-acting player in melanoma malignancy. In fact, miR-146a is able to enhance tumor growth while it suppresses dissemination. It was determined that miR-146a coordinated melanoma cell growth by its direct targets lunatic fringe (LFNG) and NUMB which operate on the NOTCH/PTEN/Akt pathway; while, inhibition of metastasis formation was linked to decreased expression of ITGAV and ROCK1...
March 10, 2016: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/26935494/differential-expression-of-micrornas-in-chronic-obstructive-pulmonary-disease
#17
Murat Kara, Gamze Kirkil, Serdar Kalemci
BACKGROUND: This study aimed to investigate the associations of miRNA with COPD patients. OBJECTIVES: Chronic obstructive pulmonary disease (COPD) is characterized by progressive and largely irreversible airflow limitation. COPD is one of the most common causes of death globally and it is still a serious public health problem worldwide. Pathogenesis of COPD is multifactorial including genetics and environmental factors. MATERIAL AND METHODS: Sixty patients who were diagnosed with COPD according to GOLD guidance and 40 controls were involved in the study...
January 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/26859141/integrated-microrna-and-mrna-signature-associated-with-the-transition-from-the-locally-confined-to-the-metastasized-clear-cell-renal-cell-carcinoma-exemplified-by-mir-146-5p
#18
Zofia Wotschofsky, Linda Gummlich, Julia Liep, Carsten Stephan, Ergin Kilic, Klaus Jung, Jean-Noel Billaud, Hellmuth-Alexander Meyer
BACKGROUND: MicroRNAs (miRNAs) regulate gene expression by interfering translation or stability of target transcripts. This interplay between miRNA and their mRNA has been proposed as an important process in cancer development and progression. We have investigated molecular networks impacted by predicted mRNA targets of differentially expressed miRNAs in patients with clear cell renal cell carcinoma (ccRCC) diagnosed with or without metastasis. MATERIAL AND METHODS: miRNA and mRNA microarray expression profiles derived from primary ccRCC from patients with (16 samples) or without diagnosed metastasis (22 samples) were used to identify anti-correlated miRNA-mRNA interaction in ccRCC...
2016: PloS One
https://www.readbyqxmd.com/read/26857476/first-feed-affects-the-expressions-of-microrna-and-their-targets-in-atlantic-cod
#19
Teshome Tilahun Bizuayehu, Tomasz Furmanek, Ørjan Karlsen, Terje van der Meeren, Rolf Brudvik Edvardsen, Ivar Rønnestad, Kristin Hamre, Steinar D Johansen, Igor Babiak
To our knowledge, there is no report on microRNA (miRNA) expression and their target analysis in relation to the type of the first feed and its effect on the further growth of fish. Atlantic cod (Gadus morhua) larvae have better growth and development performance when fed natural zooplankton as a start-feed, as compared with those fed typical aquaculture start-feeds. In our experiment, two groups of Atlantic cod larvae were fed reference feed (zooplankton, mostly copepods, filtered from a seawater pond) v. aquaculture feeds: enriched rotifers (Brachionus sp...
April 14, 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/26761003/circulating-micrornas-as-biomarkers-for-sepsis
#20
REVIEW
Fabian Benz, Sanchari Roy, Christian Trautwein, Christoph Roderburg, Tom Luedde
Sepsis represents a major cause of lethality during intensive care unit (ICU) treatment. Pharmacological treatment strategies for sepsis are still limited and mainly based on the early initiation of antibiotic and supportive treatment. In this context, numerous clinical and serum based markers have been evaluated for the diagnosis, the severity, and the etiology of sepsis. However until now, few of these factors could be translated into clinical use. MicroRNAs (miRNAs) do not encode for proteins but regulate gene expression by inhibiting the translation or transcription of their target mRNAs...
January 9, 2016: International Journal of Molecular Sciences
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