Yisheng Chen, Xiaofeng Chen, Zhiwen Luo, Xueran Kang, Yunshen Ge, Renwen Wan, Qian Wang, Zhihua Han, Fangqi Li, Zhongcheng Fan, Yuchun Xie, Beijie Qi, Xintao Zhang, Zhenwei Yang, John H Zhang, Danping Liu, Yuzhen Xu, Dongyan Wu, Shiyi Chen
INTRODUCTION: Alzheimer's Disease (AD), a progressive neurodegenerative disorder, is marked by cognitive deterioration and heightened neuroinflammation. The influence of Insulin-like Growth Factor 1 Receptor (IGF1R) and its post-translational modifications, especially sumoylation, is crucial in understanding the progression of AD and exploring novel therapeutic avenues. OBJECTIVES: This study investigates the impact of exercise on the sumoylation of IGF1R and its role in ameliorating AD symptoms in APP/PS1 mice, with a specific focus on neuroinflammation and innovative therapeutic strategies...
March 31, 2024: Journal of Advanced Research