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https://www.readbyqxmd.com/read/29457498/factors-associated-with-maternal-depression-in-the-maldives-a-prospective-cohort-study
#1
R Abdul Raheem, Hui J Chih, Colin W Binns
The aim of the study was to document perinatal depression in mothers in the Maldives and associated factors. A cohort of 458 mothers was recruited at the 2 major hospitals in Malé, the Maldives, and followed from 36 weeks of pregnancy to 3 months after birth. The Edinburgh Postnatal Depression Scale (EPDS) was used to measure maternal depression. Maternal sociodemographic factors and infant's health were also recorded. The prevalence of depressive symptoms (EPDS score ≥13) at 36 weeks of pregnancy and at 1 and 3 months postpartum were 24%, 27%, and 12%, respectively...
February 1, 2018: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/29457248/duty-hours-restriction-for-our-surgical-trainees-an-ethical-obligation-or-a-bad-idea
#2
REVIEW
Christopher A Adin, Callie A Fogle, Steven L Marks
To ensure patient safety and protect the well-being of interns and residents, the Accreditation Council for Graduate Medical Education (ACGME) issued guidelines in 2003 limiting the working hours of physician trainees. Although many supported the goals of the ACGME, institutions struggled to restructure their programs and hire staff required by this unfunded mandate. Numerous studies have analyzed the effects of duty hours restrictions on patient outcomes and physician training over the past 15 years. Most agree that duty hours restrictions improved well-being of house officers, but these improvements came at the expense of continuity, and patient hand-offs led to medical errors...
February 19, 2018: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/29456585/neuroinflammation-and-neurohormesis-in-the-pathogenesis-of-alzheimer-s-disease-and-alzheimer-linked-pathologies-modulation-by-nutritional-mushrooms
#3
REVIEW
Angela Trovato Salinaro, Manuela Pennisi, Rosanna Di Paola, Maria Scuto, Rosalia Crupi, Maria Teresa Cambria, Maria Laura Ontario, Mario Tomasello, Maurizio Uva, Luigi Maiolino, Edward J Calabrese, Salvatore Cuzzocrea, Vittorio Calabrese
Human life develops and expands not only in time and space, but also in the retrograde permanent recollection and interweaving of memories. Therefore, individual human identity depends fully on a proper access to the autobiographical memory. Such access is hindered or lost under pathological conditions such as Alzheimer's disease, including recently associated oxidant pathologies, such as ocular neural degeneration occurring in glaucoma or neurosensorial degeneration occurring in Menière's disease. Oxidative stress and altered antioxidant systems have been suggested to play a role in the aetiology of major neurodegenerative disorders, and altered expression of genes sensing oxidative stress, as well as decreased cellular stress response mechanisms could synergistically contribute to the course of these oxidant disorders...
2018: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29455900/heart-rate-variability-is-associated-with-psychosocial-stress-in-distinct-social-domains
#4
Alexander Lischke, Robert Jacksteit, Anett Mau-Moeller, Rike Pahnke, Alfons O Hamm, Matthias Weippert
OBJECTIVE: Psychosocial stress is associated with substantial morbidity and mortality. Accordingly, there is a growing interest in biomarkers that indicate whether individuals show adaptive (i.e., stress-buffering and health-promoting) or maladaptive (i.e., stress-escalating and health-impairing) stress reactions in social contexts. As heart rate variability (HRV) has been suggested to be a biomarker of adaptive behavior during social encounters, it may be possible that inter-individual differences in HRV are associated with inter-individual differences regarding stress in distinct social domains...
March 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29455895/childhood-trauma-and-resilience-in-psoriatic-patients-a-preliminary-report
#5
Maria Luigia Crosta, Clara De Simone, Salvatore Di Pietro, Mariateresa Acanfora, Giacomo Caldarola, Lorenzo Moccia, Antonino Callea, Isabella Panaccione, Ketty Peris, Lucio Rinaldi, Luigi Janiri, Marco Di Nicola
AIMS: Psoriasis is a chronic inflammatory skin disease with a complex etiology, involving the immune system, genetic factors, and external/internal triggers, with psychosomatic aspects. The aim of the study was to investigate childhood trauma and resilience in a psoriatic sample compared with healthy controls. Correlations between childhood trauma, resilience, quality of life, clinical data and psoriatic features were also evaluated. METHODS: Seventy-seven psoriatic patients and seventy-six homogeneous healthy controls were enrolled...
March 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29455516/core-shell-microneedle-gel-for-self-regulated-insulin-delivery
#6
Jinqiang Wang, Yanqi Ye, Jicheng Yu, Anna R Kahkoska, Xudong Zhang, Chao Wang, Wujin Sun, Ria D Corder, Zhaowei Chen, Saad A Khan, John B Buse, Zhen Gu
A bioinspired glucose-responsive insulin delivery system for self-regulation of blood glucose levels is desirable for improving health and quality of life outcomes for patients with type 1 and advanced type 2 diabetes. Here we describe a painless core-shell microneedle array patch consisting of degradable cross-linked gel for smart insulin delivery with rapid responsiveness and excellent biocompatibility. This gel-based device can partially dissociate and subsequently release insulin when triggered by hydrogen peroxide (H2 O2 ) generated during the oxidation of glucose by a glucose-specific enzyme covalently attached inside the gel...
February 19, 2018: ACS Nano
https://www.readbyqxmd.com/read/29455045/impact-of-transvaginal-modified-sacrospinous-ligament-fixation-with-mesh-for-the-treatment-of-pelvic-organ-prolapse-before-and-after-studies
#7
Qinyi Zhu, Huimin Shu, Guiqiang Du, Zhiyuan Dai
BACKGROUND: Pelvic organ prolapse (POP) is a common disease in women. The aim of this research was to evaluate the safety, efficacy and complication of transvaginal modified sacrospinous ligament fixation with mesh using for the treatment of vaginal vault prolapse. MATERIALS AND METHODS: This was a prospective study including information from 60 symptomatic women with anterior-apical pelvic floor prolapse. The patients underwent transvaginal modified sacrospinous ligament fixation combined with anterior vaginal wall mesh between May 2014 and Sep 2015...
February 15, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29454344/validation-of-a-core-patient-reported-outcome-measure-set-for-operationalizing-success-in-multimodal-pain-therapy-useful-for-depicting-long-term-success
#8
Carolin Donath, Christa Geiß, Christoph Schön
BACKGROUND: The study aims to validate a previously developed and published combined success criterion for patients after multimodal pain therapy (Donath et al., BMC Health Serv Res 15:272, 2015). The criterion classifies treated patients as successful in the long term on the basis of pain severity, disability through pain, depressiveness, and health-related quality of life. METHODS: Routine longitudinal data of 135 pain patients treated with multimodal pain therapy in 2014-2015 at the Interdisciplinary Pain Center of the University Clinic Erlangen were available at baseline, therapy start, therapy end, and 12 months after treatment...
February 17, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29454315/prevalence-and-correlates-of-positive-mental-health-in-chinese-adolescents
#9
Cheng Guo, Göran Tomson, Christina Keller, Fredrik Söderqvist
BACKGROUND: Studies investigating the prevalence of positive mental health and its correlates are still scarce compared to the studies on mental disorders, although there is growing interest of assessing positive mental health in adolescents. So far, no other study examining the prevalence and determinants of positive mental health in Chinese adolescents has been found. The purpose of this study was to assess the prevalence and correlates of positive mental health in Chinese adolescents...
February 17, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29454114/mitochondria-targeting-mitochondrial-reactive-oxygen-species-with-mitochondriotropic-polyphenolic-based-antioxidants
#10
José Teixeira, Cláudia M Deus, Fernanda Borges, Paulo J Oliveira
Mitochondrial function and regulation of redox balance is fundamental in controlling cellular life and death pathways. Antioxidants have been used to counteract disruption of redox networks, normally associated with progressive loss of cell homeostasis and disease pathophysiology, although therapeutic success is limited mainly due to pharmacokinetic drawbacks. Attempts to improve mitochondrial function in a range of diseases spurred active drug discovery efforts. Currently, the most effective strategy to deliver drugs to mitochondria is the covalent link of lipophilic cations to the bioactive compound...
February 14, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29453937/trajectory-classes-of-cannabis-use-and-heavy-drinking-among-rural-african-american-adolescents-multilevel-predictors-of-class-membership
#11
Allen W Barton, Gene H Brody, Tamika C B Zapolski, Trenette C Goings, Steven M Kogan, Michael Windle, Tianyi Yu
AIMS: To inform research on the etiology and prevention of substance use among rural African American youth by (a) identifying developmental trajectory classes of cannabis use and heavy drinking across adolescence and young adulthood, and (b) examining associations between trajectory class membership and multi-level assessments of risk factors. DESIGN: A prospective study spanning nine years with assessments of cannabis use and heavy drinking, the catecholamines epinephrine and norepinephrine, perceived stress, and psychosocial risk factors...
February 17, 2018: Addiction
https://www.readbyqxmd.com/read/29453534/nanoparticles-caused-oxidative-imbalance
#12
Mariusz Zuberek, Agnieszka Grzelak
Application of nanomaterials in nearly every single branch of industry results in their accumulation in both abiotic environment and tissues of living organisms. Despite the common use of nanomaterials, we are not able to precisely define their toxicity towards humans and surrounding biota. Although we were able to determine final effects of chronic exposure to nanoparticles which consist of many pathologies such as respiratory diseases, allergies, diseases of cardiovascular system, disorders in embryonic life differentiation and growth disorders, toxic effects on the immune system and cancers...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29453255/endophyte-mediated-modulation-of-defense-responsive-genes-and-systemic-resistance-in-withania-somnifera-l-dunal-under-alternaria-alternata-stress
#13
Aradhana Mishra, Satyendra Pratap Singh, Sahil Mahfooz, Surendra Pratap Singh, Arpita Bhattacharya, Nishtha Mishra, C S Nautiyal
Endophytes have been explored to perform an important role in plant health. However, their effects on the host physiological function and disease management remains elusive. The present study was aimed to assess the potential of endophytes singly as well as in combination on various physiological parameters and systemic defense mechanism against Alternaria alternata in Withania somnifera (L.) Dunal. Seed priming with endophytic Bacillus amyloliquefaciens and Pseudomonas fluorescens individually and in combination demonstrated enhanced vigor index and germination rate...
February 16, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29452985/effectiveness-of-two-home-ergonomic-programs-in-reducing-pain-and-enhancing-quality-of-life-in-informal-caregivers-of-post-stroke-patients-a-pilot-randomized-controlled-clinical-trial
#14
Karen Lucia de Araújo Freitas Moreira, Gracia María Ábalos-Medina, Carmen Villaverde-Gutiérrez, Neide María Gomes de Lucena, Anderson Belmont Correia de Oliveira, José Manuel Pérez-Mármol
BACKGROUND: Informal caregivers of post-stroke patients usually undergo high levels of pain and stress and have a reduced quality of life. OBJECTIVE: To evaluate the effectiveness of two home ergonomic interventions aimed at reducing pain intensity and perceived stress and enhancing the quality of life in informal caregivers of chronic post-stroke patients. METHODS: A randomized single-blind controlled clinical trial was conducted, with a sample of 33 informal caregivers of patients with stroke...
February 13, 2018: Disability and Health Journal
https://www.readbyqxmd.com/read/29452966/gender-differences-in-the-relationship-of-childhood-trauma-and-the-course-of-illness-in-schizophrenia
#15
Krisztina Kocsis-Bogár, Veronika Mészáros, Dóra Perczel-Forintos
INTRODUCTION: Different types of childhood trauma have been repeatedly shown to contribute to psychotic symptoms. Gender differences in schizophrenia are well known. Some studies argue that trauma history means a significantly higher risk of psychosis for women than men. However, there is evidence of early adverse life events to be associated with higher stress-sensitivity in men. Little is known about the connection of specific type of trauma and specific psychotic symptoms as well as the course of illness with explicit regard to gender differences...
February 13, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29451967/cognitive-behavioral-therapy-for-anxiety-and-related-disorders-a-meta-analysis-of-randomized-placebo-controlled-trials
#16
REVIEW
Joseph K Carpenter, Leigh A Andrews, Sara M Witcraft, Mark B Powers, Jasper A J Smits, Stefan G Hofmann
The purpose of this study was to examine the efficacy of cognitive behavioral therapy (CBT) for anxiety-related disorders based on randomized placebo-controlled trials. We included 41 studies that randomly assigned patients (N = 2,843) with acute stress disorder, generalized anxiety disorder (GAD), obsessive compulsive disorder (OCD), panic disorder (PD), posttraumatic stress disorder (PTSD), or social anxiety disorder (SAD) to CBT or a psychological or pill placebo condition. Findings demonstrated moderate placebo-controlled effects of CBT on target disorder symptoms (Hedges' g = 0...
February 16, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29451956/posttraumatic-stress-disorder-ptsd-and-complex-ptsd-cptsd-as-per-icd-11-proposals-a-population-study-in-israel
#17
Menachem Ben-Ezra, Thanos Karatzias, Philip Hyland, Chris R Brewin, Marylene Cloitre, Jonathan I Bisson, Neil P Roberts, Brigitte Lueger-Schuster, Mark Shevlin
BACKGROUND: The current study sought to advance the existing literature by providing the first assessment of the factorial and discriminant validity of the ICD-11 proposals for posttraumatic stress disorder (PTSD) and complex PTSD (CPTSD) in a nationwide level. METHODS: A nationally representative sample from Israel (n = 1,003) using a disorder-specific measure (ITQ; International Trauma Questionnaire) in order to assess PTSD and CPTSD along with the Life Events Checklist and the World Health Organization Well-Being Index...
February 16, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29451830/quality-of-life-and-african-american-women-who-are-family-caregivers-a-literature-review-with-implications-for-psychiatric-mental-health-advanced-practice-registered-nurses
#18
Shaquita A Starks, Freida Outlaw, J Carolyn Graff, Wendy Likes, Shelley White-Means, Laura Melaro, Mona N Wicks
PURPOSE: To identify factors affecting the quality of life (QOL) of African American women (AAW) family caregivers of individuals with kidney failure. METHODS: Ferrans' Conceptual Model of QOL provided the framework for this literature review. Included studies were (a) peer- reviewed, (b) published within the last ten years, (c) written in English, and (d) examined QOL of AAW family caregivers. Using CINAHL© and PubMed©, we found 14 studies that described factors associated with these caregivers' QOL...
February 16, 2018: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/29451817/the-impact-of-pulse-pressure-on-cerebrovascular-events-leading-to-age-related-cognitive-decline
#19
Nathalie Thorin-Trescases, Olivia de Montgolfier, Anthony Pinçon, Adeline Raignault, Laurie Caland, Pauline Labbé, Eric Thorin
Aging is a modern concept: human life expectancy has more than doubled in less than 150 years in Western countries. Longer lifespan, however, reveals age-related diseases, including cerebrovascular diseases. The vascular system is a prime target of aging: the "wear and tear" of large elastic arteries exposed to a life-long pulsatile pressure causes arterial stiffening by fragmentation of elastin fibers and replacement by stiffer collagen. This arterial stiffening increases in return the amplitude of the pulse pressure (PP), its wave penetrating deeper into the microcirculation of low resistance, high flow organs such as the brain...
February 16, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29451694/children-with-facial-morphea-managing-everyday-life-a-qualitative-study
#20
E Stasiulis, B Gladstone, K Boydell, C O'Brien, E Pope, R Laxer
BACKGROUND: This study explores the everyday experiences of children with facial morphea by examining the psychosocial impact of living with facial morphea and how children and their families manage its impact. METHODS: We used a qualitative, social constructionist approach involving focus groups, in-depth interviews and drawing activities with 10 children with facial morphea 8-17 years of age and 13 parents. Interpretive thematic analysis was utilized to examine the data...
February 16, 2018: British Journal of Dermatology
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