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https://www.readbyqxmd.com/read/29053597/time-variant-reliability-analysis-for-rubber-o-ring-seal-considering-both-material-degradation-and-random-load
#1
Baopeng Liao, Bo Sun, Meichen Yan, Yi Ren, Weifang Zhang, Kun Zhou
Due to the increase in working hours, the reliability of rubber O-ring seals used in hydraulic systems of transfer machines will change. While traditional methods can only analyze one of the material properties or seal properties, the failure of the O-ring is caused by these two factors together. In this paper, two factors are mainly analyzed: the degradation of material properties and load randomization by processing technology. Firstly, the two factors are defined in terms of material failure and seal failure, before the experimental methods of rubber materials are studied...
October 20, 2017: Materials
https://www.readbyqxmd.com/read/29053140/measurement-of-bh3-only-protein-tolerance
#2
Haiming Dai, Husheng Ding, Kevin L Peterson, X Wei Meng, Paula A Schneider, Katherine L B Knorr, Scott H Kaufmann
The BCL2 family of proteins regulates cellular life and death decisions. Among BCL2 family members, BH3-only proteins have critical roles by neutralizing antiapoptotic family members, as well as directly activating BAX and BAK. Despite widespread occurrence of BH3-only protein upregulation in response to various stresses, this process is rarely quantified. Moreover, it is unclear whether all BH3-only proteins are equipotent at inducing cell death. Here we show that BH3-only proteins increase as much as 15- to 20-fold after various treatments and define a parameter, termed BH3-only tolerance, which measures how many copies of a particular BH3-only protein can be expressed before the majority of cells in a population undergo apoptosis...
October 20, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29052972/impaired-intestinal-barrier-function-and-relapsing-digestive-disease-lessons-from-a-porcine-model-of-early-life-stress
#3
REVIEW
A L Ziegler, A T Blikslager
Within this issue of Neurogastroenterology and Motility, an article by Pohl et al highlights new insights from a powerful porcine model of the link between early life adversity and relapsing functional gastrointestinal disorders. Early weaning stress closely mimics the early life psychosocial stressors that have been linked to adult onset gastrointestinal dysfunction. This early weaning model provides reproducible and highly translatable outcomes in young stress-challenged pigs. Due to the convincingly comparable neurological and gastroenterological anatomy and physiology between pigs and human beings, gastrointestinal stress and injury studies utilizing swine models will provide invaluable insights to improve our understanding and treatment of gastrointestinal disease in human beings...
November 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29052307/instrumental-learning-and-cognitive-flexibility-processes-are-impaired-in-children-exposed-to-early-life-stress
#4
Madeline B Harms, Katherine E Shannon Bowen, Jamie L Hanson, Seth D Pollak
Children who experience severe early life stress show persistent deficits in many aspects of cognitive and social adaptation. Early stress might be associated with these broad changes in functioning because it impairs general learning mechanisms. To explore this possibility, we examined whether individuals who experienced abusive caregiving in childhood had difficulties with instrumental learning and/or cognitive flexibility as adolescents. Fifty-three 14-17-year-old adolescents (31 exposed to high levels of childhood stress, 22 control) completed an fMRI task that required them to first learn associations in the environment and then update those pairings...
October 19, 2017: Developmental Science
https://www.readbyqxmd.com/read/29052096/life-paths-of-patients-with-transthyretin-related-familial-amyloid-polyneuropathy-val30met-a-descriptive-study
#5
Alice Lopes, Alexandra Sousa, Isabel Fonseca, Margarida Branco, Carla Rodrigues, Teresa Coelho, Jorge Sequeiros, Paula Freitas
Transthyretin-related familial amyloid polyneuropathy Val30Met is a fatal progressive disease. It is a rare hereditary amyloidosis, manifesting as a sensorimotor neuropathy and autonomic dysfunction. It begins during adulthood and is a disabling disease, posing a great psychological burden to patients and their families. Our aim was to describe and characterize life events related to the disease and discuss its psychosocial implications. Social and demographic data and a questionnaire on history of family and personal disease, and biographic events, were applied to 209 subjects attending an outpatient specialized clinic...
October 19, 2017: Journal of Community Genetics
https://www.readbyqxmd.com/read/29052046/headache-and-pregnancy-a-systematic-review
#6
A Negro, Z Delaruelle, T A Ivanova, S Khan, R Ornello, B Raffaelli, A Terrin, U Reuter, D D Mitsikostas
This systematic review summarizes the existing data on headache and pregnancy with a scope on clinical headache phenotypes, treatment of headaches in pregnancy and effects of headache medications on the child during pregnancy and breastfeeding, headache related complications, and diagnostics of headache in pregnancy. Headache during pregnancy can be both primary and secondary, and in the last case can be a symptom of a life-threatening condition. The most common secondary headaches are stroke, cerebral venous thrombosis, subarachnoid hemorrhage, pituitary tumor, choriocarcinoma, eclampsia, preeclampsia, idiopathic intracranial hypertension, and reversible cerebral vasoconstriction syndrome...
October 19, 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29051086/depression-subtyping-based-on-evolutionary-psychiatry-proximate-mechanisms-and-ultimate-functions
#7
REVIEW
Markus J Rantala, Severi Luoto, Indrikis Krams, Hasse Karlsson
Major depressive disorder constitutes one of the leading causes of disability worldwide. However, it is not a unitary disease-it is a heterogeneous syndrome, with patients differing remarkably in symptom profile, pathophysiology and treatment responsiveness. Previous attempts to subtype major depressive disorder have showed limited clinical applicability. We present a classification of major depressive disorder episodes based on the proximate mechanisms that led to the original mood change that caused the depressive episode...
October 16, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29051045/angiotensin-ii-regulates-%C3%AE-enac-in-human-umbilical-vein-endothelial-cells
#8
Charles A Downs, Nicholle M Johnson, Camila Coca, My N Helms
The amiloride-sensitive epithelial sodium channel (ENaC) has been characterized in a variety of non-epithelial tissues. In the current study we sought to understand the effect of angiotensin II on δ ENaC function using human umbilical vein endothelial cells (HUVECs). The δ ENaC subunit is found in humans, but notably absent in rat and most mouse epithelial tissues. In this study we report the presence of δ ENaC in HUVECS with a half-life of ~80min and a change in δ ENaC abundance when HUVECs were treated with angiotensin II...
October 16, 2017: Microvascular Research
https://www.readbyqxmd.com/read/29050993/psychological-causes-of-autobiographical-amnesia-a-study-of-28-cases
#9
Angelica Staniloiu, Hans J Markowitsch, Andreas Kordon
Autobiographical amnesia is found in patients with focal or diffuse brain damage ("organic amnesia"), but also without overt brain damage (at least when measured with conventional brain imaging methods). This last condition is usually named dissociative amnesia at present, and was originally described as hysteria. Classically and traditionally, dissociative amnesia is seen as a disorder that causes retrograde amnesia in the autobiographical domain in the aftermath of incidents of major psychological stress or trauma...
October 16, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29049509/prenatal-air-pollution-and-newborns-predisposition-to-accelerated-biological-aging
#10
Dries S Martens, Bianca Cox, Bram G Janssen, Diana B P Clemente, Antonio Gasparrini, Charlotte Vanpoucke, Wouter Lefebvre, Harry A Roels, Michelle Plusquin, Tim S Nawrot
Importance: Telomere length is a marker of biological aging that may provide a cellular memory of exposures to oxidative stress and inflammation. Telomere length at birth has been related to life expectancy. An association between prenatal air pollution exposure and telomere length at birth could provide new insights in the environmental influence on molecular longevity. Objective: To assess the association of prenatal exposure to particulate matter (PM) with newborn telomere length as reflected by cord blood and placental telomere length...
October 16, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/29049332/blue-lighting-accelerates-post-stress-relaxation-results-of-a-preliminary-study
#11
Jesus Minguillon, Miguel Angel Lopez-Gordo, Diego A Renedo-Criado, Maria Jose Sanchez-Carrion, Francisco Pelayo
Several authors have studied the influence of light on both human physiology and emotions. Blue light has been proved to reduce sleepiness by suppression of melatonin secretion and it is also present in many emotion-related studies. Most of these have a common lack of objective methodology since results and conclusions are based on subjective perception of emotions. The aim of this work was the objective assessment of the effect of blue lighting in post-stress relaxation, in comparison with white lighting, by means of bio-signals and standardized procedures...
2017: PloS One
https://www.readbyqxmd.com/read/29049052/a-cost-utility-analysis-of-nonsurgical-treatments-for-stress-urinary-incontinence-in-women
#12
Andrea N Simpson, Alaina Garbens, Fahima Dossa, Peter C Coyte, Nancy N Baxter, Colleen D McDermott
OBJECTIVE: The objective of this study was to perform a cost-utility analysis of nonsurgical treatments for stress urinary incontinence (SUI) in healthy adult women with a health system perspective over a 1-year time horizon. METHODS: A decision tree model was constructed to evaluate the following nonsurgical treatment options for SUI in a simulated healthy adult female cohort who had failed Kegel exercises: pelvic floor muscle therapy (PFMT), a disposable tampon device (Impressa), a self-fitting intravaginal incontinence device (Uresta), and a traditional incontinence pessary...
October 18, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29048590/family-functioning-medical-self-management-and-health-outcomes-among-school-aged-children-with-sickle-cell-disease-a-mediation-model
#13
Alexandra M Psihogios, Lauren C Daniel, Reem Tarazi, Kim Smith-Whitley, Chavis A Patterson, Lamia P Barakat
Background: Informed by the Pediatric Self-Management Model, the present study tested relationships between parent and family functioning, sickle cell disease (SCD) self-management, and health outcomes for children with SCD. Method: 83 children with SCD and a parent completed baseline data as part of a larger investigation of a family-based, problem-solving intervention for children with SCD (M age = 8.47). Youth and parents completed a measure of child health-related quality of life (HRQOL), and parents completed measures of family efficacy, parenting stress, and SCD self-management...
September 26, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29048519/finding-silver-linings-a-preliminary-examination-of-benefit-finding-in-youth-with-chronic-pain
#14
Sabine Soltani, Alex Neville, Karen Hurtubise, Aimee Hildenbrand, Melanie Noel
Background: Chronic pain is a pervasive condition in adolescence and is associated with significant psychological distress, functional disability, social isolation, and decreased quality of life for a subset of affected youth. There is a paucity of research examining potential resilience factors and adaptive processes in pediatric chronic pain. Benefit finding refers to the process of perceiving positive consequences in the face of adversity. Previous research on benefit finding in pediatric samples (e...
October 12, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29048212/living-too-long-exploring-attitudes-toward-reaching-100-years-old
#15
Oscar Ribeiro, Sofia Canedo, Margarida Cerqueira, Ana Nascimento, Laetitia Teixeira
Objective This study analyses the relationship between pro- and anti-longevity attitudes, attitudes toward centenarians, and the wish to reach 100 years of age in a sample of community dwelling older adults. Methods Participants ( N = 137) completed a questionnaire on attitudes toward life-extension and an aging semantic differential using centenarians as an attitudinal target. Sociodemographic information, perceived health status, and information on knowing a centenarian were also obtained. A cluster analysis was used to identify subgroups (leaning anti-longevity group vs...
January 1, 2017: International Journal of Aging & Human Development
https://www.readbyqxmd.com/read/29047102/reactive-oxygen-species-in-copd-related-vascular-remodeling
#16
Li Zuo, Chia-Chen Chuang, Alexander D Clark, Davis E Garrison, Jamie L Kuhlman, David C Sypert
The pathogenesis of chronic obstructive pulmonary disease (COPD) is a multifaceted process involving the alteration of pulmonary vasculature. Such vascular remodeling can be associated with inflammation, shear stress, and hypoxia-conditions commonly seen in patients with lung diseases. Particularly, the overproduction of reactive oxygen species (ROS) in the diseased lungs contributes greatly to pulmonary vascular remodeling. ROS play an important role in vascular homeostasis, yet excessive ROS can alter pulmonary vasculature and impair lung function, as implicated in COPD at all stages...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29046646/role-of-sex-hormones-in-the-control-of-vegetative-and-metabolic-functions-of-middle-aged-women
#17
Vincenzo Monda, Monica Salerno, Moscatelli Fiorenzo, Ines Villano, Andrea Viggiano, Francesco Sessa, Antonio I Triggiani, Giuseppe Cibelli, Anna Valenzano, Gabriella Marsala, Christian Zammit, Maria Ruberto, Giovanni Messina, Marcellino Monda, Vincenzo De Luca, Antonietta Messina
Aims: In women's life, menopause is characterized by significant physiological changes often associated with an increase in body mass and obesity-associated sicknesses. Numerous researches described interdependencies of estrogen deficiency, aging, and resting energy expenditure (REE) downfall in the obesity correlated with the menopause. The aim of this study was to determining whether healthy, obese menopausal women underwent HRT treatment, showed changes in their REE, autonomic asset, and assessment of oxidative stress in comparison with obese pre- and post-menopausal women...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29046400/ribosome-biogenesis-modulates-ty1-copy-number-control-in-saccharomyces-cerevisiae
#18
Hyo Won Ahn, Jessica M Tucker, Joshua A Arribere, David J Garfinkel
Transposons can impact the host genome by altering gene expression and participating in chromosome rearrangements. Therefore, organisms evolved different ways to minimize the level of transposition. In Saccharomyces cerevisiae and its close relative S. paradoxus, Ty1 copy number control (CNC) is mediated by the self-encoded restriction factor p22, which is derived from the GAG capsid gene and inhibits virus-like particle (VLP) assembly and function. Based on secondary screens of Ty1 cofactors, we identified LOC1, a RNA localization/ribosome biogenesis gene that affects Ty1 mobility predominantly in strains harboring Ty1 elements...
October 18, 2017: Genetics
https://www.readbyqxmd.com/read/29045750/aging-and-hiv-related-caregiving-in-sub-saharan-africa-a-social-ecological-approach
#19
Jeon Small, Carolyn Aldwin, Paul Kowal, Somnath Chatterji, Rachel Pruchno
Background and Objectives: We reviewed the literature on older adults (OAs) who are caring for persons living with HIV/AIDS in sub-Saharan Africa (SSA), with the goal of adapting models of caregiver stress and coping to include culturally relevant and contextually appropriate factors specific to SSA, drawing on both life course and cultural capital theories. Research Design and Methods: A systematic literature search found 81 articles published between 1975 and 2016 which were reviewed using a narrative approach...
October 17, 2017: Gerontologist
https://www.readbyqxmd.com/read/29045669/genetic-decoupling-of-thermal-hardiness-across-metamorphosis-in-drosophila-melanogaster
#20
Philip J Freda, Jackson T Alex, Theodore J Morgan, Gregory J Ragland
As organisms age the environment fluctuates, exerting differential selection across ontogeny. In particular, highly seasonal environments expose life stages to often drastically different thermal environments. This developmental variation is particularly striking in organisms with complex life cycles, wherein life history stages also exhibit distinct morphologies, physiologies, and behaviors. Genes acting pleiotropically on thermal responses may produce genetic correlations across ontogeny, constraining the independent evolution of each life stage to their respective thermal environments...
October 16, 2017: Integrative and Comparative Biology
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