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https://www.readbyqxmd.com/read/29241299/nmr-elucidation-of-monomer-dimer-transition-and-conformational-heterogeneity-in-histone-like-dna-binding-protein-of-helicobacter-pylori-hup
#1
Nancy Jaiswal, Nisha Raikwal, Himanshu Pandey, Nipanshu Agarwal, Ashish Arora, Krishna Mohan Poluri, Dinesh Kumar
Helicobacter pylori (H. pylori) colonizes under harsh acidic/oxidative stress conditions of human gastrointestinal tract and can survive there for infinitely longer durations of host life. The bacterium expresses several harbinger proteins to facilitate its persistent colonization under such conditions. One such protein in H. pylori is Histone like DNA binding protein (Hup) which in its homo-dimeric form binds to DNA to perform various DNA dependent cellular activities. Further, it also plays an important role in protecting the genomic DNA from oxidative stress and acidic denaturation...
December 14, 2017: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/29241286/-humor-in-medicine-the-art-of-leaping-over-the-shadows
#2
Barbara Wild
Humor and laughter are integral parts of human life and communication - and so of course they occur in medical contacts.Humor is defined as a personality based cognitive emotional style of processing situations, characterized by the ability to find positive aspects even in negative situations, and the ability to communicate this point of view to others and to cheer them up. Humor can support healing processes and coping with illness. Humor and jokes reduce anxiety and stress (for patients and doctors). Humorous people have a more realistic, flexible and less fearful behaviour...
December 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29240831/comparative-transcriptome-profiling-of-virulent-and-non-virulent-trypanosoma-cruzi-underlines-the-role-of-surface-proteins-during-infection
#3
A Trey Belew, Caroline Junqueira, Gabriela F Rodrigues-Luiz, Bruna M Valente, Antonio Edson R Oliveira, Rafael B Polidoro, Luciana W Zuccherato, Daniella C Bartholomeu, Sergio Schenkman, Ricardo T Gazzinelli, Barbara A Burleigh, Najib M El-Sayed, Santuza M R Teixeira
Trypanosoma cruzi, the protozoan that causes Chagas disease, has a complex life cycle involving several morphologically and biochemically distinct stages that establish intricate interactions with various insect and mammalian hosts. It has also a heterogeneous population structure comprising strains with distinct properties such as virulence, sensitivity to drugs, antigenic profile and tissue tropism. We present a comparative transcriptome analysis of two cloned T. cruzi strains that display contrasting virulence phenotypes in animal models of infection: CL Brener is a virulent clone and CL-14 is a clone that is neither infective nor pathogenic in in vivo models of infection...
December 14, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29240594/preventive-effect-of-a-microclimate-regulating-system-on-pressure-ulcer-development-a-prospective-randomized-controlled-trial-in-dutch-nursing-homes
#4
Martin van Leen, Ruud Halfens, Jos Schols
OBJECTIVE: Prevention of pressure ulcers (PrUs) is based on relieving pressure, diminishing shear stress, and controlling the skin's microclimate. Based on the recommendations in the most recent guideline for prevention of PrUs, a pressure-relieving, shear stress-diminishing, and microclimate-controlling skin interface multilayer support system (Bedcare; Sense Textile, 's-Hertogenbosch, the Netherlands) has been developed for use on top of a viscoelastic foam mattress (Formafoam, Kabelfabriek Eupen, Belgium)...
January 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29240527/depressive-symptom-prevalence-and-predictors-in-the-first-half-of-pregnancy
#5
Patricia Anne Kinser, Leroy R Thacker, Dana Lapato, Sara Wagner, Roxann Roberson-Nay, Lisa Jobe-Shields, Ananda Amstadter, Timothy P York
INTRODUCTION: Major depression during the peripartum (MDP) period carries significant public health impact due to the potential adverse effects on maternal, infant, and family outcomes. METHODS: As part of a larger longitudinal study, this cross-sectional observational study sought to build upon the current literature on the prevalence and predictors of depression in the early second trimester of pregnancy, as related to generally accepted risk factors and other less explored risk factors...
December 14, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/29239294/demographics-interests-and-quality-of-life-of-canadian-neurosurgery-residents
#6
Christian Iorio-Morin, Syed Uzair Ahmed, Mark Bigder, Ayoub Dakson, Cameron Elliott, Daipayan Guha, Michelle Kameda-Smith, Pascal Lavergne, Serge Makarenko, Michael S Taccone, Michael K Tso, Bill Wang, Alexander Winkler-Schwartz, David Fortin
BACKGROUND: Neurosurgical residents face a unique combination of challenges, including long duty hours, technically challenging cases, and uncertain employment prospects. We sought to assess the demographics, interests, career goals, self-rated happiness, and overall well-being of Canadian neurosurgery residents. METHODS: A cross-sectional survey was developed and sent through the Canadian Neurosurgery Research Collaborative to every resident enrolled in a Canadian neurosurgery program as of April 1, 2016...
December 14, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29239280/perceived-injustice-and-its-correlates-after-mild-traumatic-brain-injury
#7
Grant L Iverson, Douglas P Terry, Justin E Karr, William Panenka, Noah D Silverberg
Perceived injustice is a belief that one has been treated unfairly, disrespectfully, and is suffering unnecessarily as a result of another person's actions. Perceived injustice predicts chronic disability after musculoskeletal injury, but to our knowledge, has not been empirically studied in people with mild traumatic brain injuries (MTBIs). We examined perceived injustice and its correlates in patients who were slow to recover from MTBI. Patients (N=102) were recruited from four concussion clinics. The sample was on average 41...
December 14, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29238608/study-protocol-for-enhancing-parenting-in-cancer-epic-development-and-evaluation-of-a-brief-psycho-educational-intervention-to-support-parents-with-cancer-who-have-young-children
#8
Lesley Stafford, Michelle Sinclair, Jane Turner, Louise Newman, Claire Wakefield, Mei Krishnasamy, G Bruce Mann, Leslie Gilham, Kylie Mason, Paula Rauch, Julia Cannell, Penelope Schofield
Background: Parents with cancer have high rates of psychological morbidity, and their children are at risk of poor psychosocial outcomes, particularly in the context of parental distress and poor family communication. Parents express concerns about the impact of cancer on their children and report a lack of professional guidance in meeting their children's needs. Few parenting interventions exist and current interventions have extensive infrastructure demands making them unsuitable for routine use in most health settings...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29238497/the-role-of-anxiety-and-depression-on-acceptance-and-action-considering-emotional-schemas-in-diabetics-of-birjand-iran
#9
Elham Imani, Fatemeh Shahabizadeh, Alireza Mahmoodirad
Background: Diabetes is one of the most common noncommunicable diseases around the world that accompanies assorted psychiatric disorders including anxiety and depression due to being chronic. Objective: The aim of this study was to evaluate the effect of anxiety and depression on acceptance and action, considering emotional schemas of diabetics referring to diabetes clinics of health centers in Birjand, Iran. Methods: This study was conducted in 2016 and was a correlational study with a structural equation modeling approach...
October 2017: Electronic Physician
https://www.readbyqxmd.com/read/29238490/gastroesophageal-reflux-disease-among-population-of-arar-city-northern-saudi-arabia
#10
Anwar Matar Alsulobi, Nagah Mohamed Abo El-Fetoh, Sara Ghazi Eid Alenezi, Razan Ahmed Alanazi, Rawan Hamdan Salem Alenazy, Fryail Aied Lafi Alenzy, Amthal Alturqi Alenzi, Aisha Melfy Al Hazmy, Kholoud Obeid Albathaly, Rehab Jazem Fattal Alruwaili, Ibtisam Matan Alanazi, Ebtihal Ahmad Ali Alghamdi, Maryam Saeed Alanazi, Najah Owaed Aienzi
Background: During the recent decade, several studies about prevalence of symptom-based GERD have revealed increase of its prevalence. In addition to the highly disturbing typical symptoms, it has a series of known consequences and may affect the quality of life. Objective: To determine the prevalence of gastroesophageal reflux disease (GERD) as well as their main characteristics and risk factors among the population of Arar City, Northern Saudi Arabia. Methods: A cross-sectional study was carried out on a sample of 302 individuals from population of Arar city from October 01, 2016 to May 30, 2017, using a researcher made questionnaire and checklist...
October 2017: Electronic Physician
https://www.readbyqxmd.com/read/29238419/correlation-between-stress-and-quality-of-life-experienced-by-caregivers-perception-of-a-group-of-healthcare-professionals
#11
Bhárbara Karolline Rodrigues Silva, Fernando Rodrigues Peixoto Quaresma, Erika da Silva Maciel, Francisco Winter Dos Santos Figueiredo, Jonathan Souza Sarraf, Fernando Adami
Aim: This study aims to evaluate the relationship between perceived level of stress and quality of life of professionals working in Prompt Service Units in the city of Palmas, Tocantins. Methods: A cross-sectional study was performed among 164 professionals from Prompt Service Units. Stress levels were evaluated using the Perceived Stress Scale. The WHOQOL-bref was used to evaluate the perception of quality of life. Quantitative variables distribution was evaluated using Shapiro-Wilk's test...
2017: Open Nursing Journal
https://www.readbyqxmd.com/read/29237811/long-term-uvb-exposure-promotes-predator-inspection-behaviour-in-a-fish
#12
Simon Vitt, Janina E Zierul, Theo C M Bakker, Ingolf P Rick
Ultraviolet-B radiation (UVB) reaching the earth's surface has increased due to human-caused stratospheric ozone depletion. Whereas the harmful effects of UVB on aquatic organisms are well studied at the molecular and cellular level, recent studies have also begun to address behavioural changes caused by sublethal amounts of UVB. However, the behavioural consequences of long-term exposure to ecologically relevant UVB levels over several life stages are virtually unknown, particularly with regard to predator-prey behaviour...
December 2017: Biology Letters
https://www.readbyqxmd.com/read/29237697/triple-a-syndrome-a-wide-spectrum-of-adrenal-dysfunction
#13
Florence Roucher-Boulez, Aude Brac de la Perrière, Aude Jacquez, Delphine Chau, Laurence Guignat, Christophe Vial, Yves Morel, Marc Nicolino, Gerald Raverot, Michel Pugeat
Objective: Triple-A or Allgrove syndrome is an autosomal recessive disorder due to mutations in the AAAS gene which encodes a nucleoporin named ALADIN. It is characterized by a classical clinical triad: Alacrima, Achalasia and Adrenal Insufficiency, the canonic symptoms that are associated with progressive peripheral neuropathy. Only a few cohorts have been reported. The objective of the present study was to characterize the various spectra of adrenal function in Triple-A patients. Methods: A retrospective clinical and biological monitoring of 14 patients (10 families) was done in a single multidisciplinary French center...
December 13, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29237550/the-effects-of-dna-methylation-on-human-psychology
#14
REVIEW
Farzeen Kader, Meenu Ghai, Leah Maharaj
DNA methylation is a fundamental epigenetic modification in the human genome; pivotal in development, genomic imprinting, X inactivation, chromosome stability, gene expression and methylation aberrations are involved in an array of human diseases. Methylation at promoters is associated with transcriptional repression, whereas gene body methylation is generally associated with gene expression. Extrinsic factors such as age, diets and lifestyle affect DNA methylation which consequently alters gene expression...
December 10, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29237473/sexual-dimorphism-in-the-hepatic-protein-response-to-a-moderate-trans-fat-diet-in-senescence-accelerated-mice
#15
Steven A Bloomer, Kathryn E Wellen, Gregory C Henderson
BACKGROUND: Aging is characterized by increases in inflammation and oxidative stress, conditions that are exacerbated by environmental factors such as diet. In this study, we investigated the effects of a trans-fatty acid (TFA) diet on the liver in adult (25 wk) and old (60 wk) senescence-accelerated mice (SAMP8 strain) of both sexes. Our goal was to assess the effects of the diet on protein markers of inflammation and oxidative stress in the liver. METHODS: Male and female mice were placed on life-long diets containing similar amounts of total fat (17%), with differing amounts of TFA: 2% (moderate TFA group) or 0...
December 13, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29237377/diet-and-brain-health-which-role-for-polyphenols
#16
Vanessa Castelli, Davide Grassi, Raffaella Bocale, Michele d'Angelo, Andrea Antonosante, Annamaria Cimini, Claudio Ferri, Giovambattista Desideri
BACKGROUND: The aging of western societies is leading to a dramatic increase in the prevalence of chronic conditions, threatening the health status and then the sustainability of our healthcare systems. In particular, dementia is being increasingly recognized as a public health priority, given its enormous socioeconomic burdens further amplified by the absence of treatments really effective in improving the clinical course of the disease. METHODS: The question of whether some degree of cognitive deterioration is an inevitable part of aging or should be considered as a pathological pre-stage of dementia is currently debated...
December 12, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29237195/-interdisciplinary-inpatient-treatment-for-adolescents-and-young-adults-16%C3%A2-%C3%A2-25-years-with-mental-illness-in-adolescent-psychiatry
#17
Anne Karow, Michael Lipp, Eva Schweigert, Mary Sengutta, Gaby Wiltfang, Linus Wittmann, Martin Lambert, Carola Bindt, Jürgen Gallinat, Michael Schulte-Markwort
Objective The investigation of clinical characteristics of patients in adolescence psychiatry relevant for transition medicine. Methodology Sociodemographic and clinical data (SCID I/II, SIPS/SOPS, SPI-A, GAF, CGI) were consecutively taken from the interdisciplinary inpatient treatment centre for adolescents and young adults with mental disorders (N = 229, aged 16 - 25). Results Average age was 19 years (38 % male, 23 % migration background). A high proportion of early mental illnesses and comorbidities (66 %), psychosis risk syndromes (20 %) and suicidality (54 %), treatment discontinuation (33 %) with daily-life, social and family stress factors (52 % positive family history, 34 % trauma) were observed and a persistently high level of support and treatment was needed despite a significant clinical improvement (p < 0...
December 13, 2017: Psychiatrische Praxis
https://www.readbyqxmd.com/read/29237154/effects-of-early-life-adversity-on-hippocampal-structures-and-associated-hpa-axis-functions
#18
Brigitte Dahmen, Vanessa B Puetz, Wolfgang Scharke, Georg G von Polier, Beate Herpertz-Dahlmann, Kerstin Konrad
Early-life adversity (ELA) is one of the major risk factors for serious mental and physical health risks later in life. ELA has been associated with dysfunctional neurodevelopment, especially in brain structures such as the hippocampus, and with dysfunction of the stress system, including the hypothalamic-pituitary-adrenal (HPA) axis. Children who have experienced ELA are also more likely to suffer from mental health disorders such as depression later in life. The exact interplay of aberrant neurodevelopment and HPA axis dysfunction as risks for psychopathology is not yet clear...
December 14, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/29236882/narratives-of-family-members-on-the-suicide-of-older-adults-in-an-amazonian-metropolis
#19
André Luis Sales da Costa, Maximiliano Loiola Ponte de Souza
OBJECTIVE: To analyze the narratives of family members on the suicide of older adults in Manaus, State of Amazonas, Brazil. METHODS: This is a qualitative study of the narratives of eight older adults, who committed suicide in the period of 2001-2012. In the analytic-interpretative process, we have tried to perform the hermeneutic double exercise: to interpret the interpretation of narrators. We have used as theoretical references authors who have investigated suicide from the perspective of gender and its correlations with the sociofamiliar context and with mental disorders...
December 11, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29236727/mental-health-behavioural-problems-and-treatment-seeking-among-students-commencing-university-in-northern-ireland
#20
Margaret McLafferty, Coral R Lapsley, Edel Ennis, Cherie Armour, Sam Murphy, Brendan P Bunting, Anthony J Bjourson, Elaine K Murray, Siobhan M O'Neill
Mental health and behavioural problems are common among students commencing university. University life can be stressful and problems often exacerbate during their course of study, while others develop disorders for the first time. The WHO World Mental Health Surveys International College Student Project aims to conduct longitudinal research to examine and monitor student mental health and wellbeing. The Ulster University Student Wellbeing study, which commenced in September 2015 in Northern Ireland (NI), was conducted as part of this initiative (wave 1, n = 739), using the WMH-CIDI to examine psychopathology...
2017: PloS One
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