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https://www.readbyqxmd.com/read/29679844/measuring-impairment-when-diagnosing-adolescent-adhd-differentiating-problems-due-to-adhd-versus-other-sources
#1
Alejandro L Vazquez, Margaret H Sibley, Mileini Campez
The DSM-5 requires clinicians to link ADHD symptoms to clinically meaningful impairments in daily life functioning. Measuring impairment during ADHD assessments may be particularly challenging in adolescence, when ADHD is often not the sole source of a youth's difficulties. Existing impairment rating scales are criticized for not specifying ADHD as the source of impairment in their instructions, leading to potential problems with rating scale specificity. The current study utilized a within subjects design (N = 107) to compare parent report of impairment on two versions of a global impairment measure: one that specified ADHD as the source of impairment (Impairment Rating Scale-ADHD) and a standard version that did not (Impairment Rating Scale)...
April 13, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29679627/diabetes-and-cancer-pathophysiological-fundamentals-of-a-dangerous-affair
#2
REVIEW
Angelo Cignarelli, Valentina Annamaria Genchi, Irene Caruso, Annalisa Natalicchio, Sebastio Perrini, Luigi Laviola, Francesco Giorgino
Diabetes and cancer are worldwide chronic diseases with a major impact on the quality and expectancy of life. Metabolic abnormalities observed during the onset and progression of diabetes may have a critical role on the initiation and progression of carcinogenesis. To date, there are no conclusive data on the mechanisms underlying the relationship between diabetes and any type of human cancer. However, recent evidence suggests that both hyperglycemia and hyperinsulinemia in diabetes could elicit cell damage responses, such as glucotoxicity, lipotoxicity and oxidative stress, which participate in the cell transformation process raising the risk of cancer development...
April 18, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29679428/estimating-sensitivity-of-seabed-habitats-to-disturbance-by-bottom-trawling-based-on-the-longevity-of-benthic-fauna
#3
Adriaan D Rijnsdorp, Stefan G Bolam, Clement Garcia, Jan Geert Hiddink, Niels T Hintzen, P Daniel van Denderen, Tobias van Kooten
Bottom fishing such as trawling and dredging may pose serious risks to the seabed and benthic habitats, calling for a quantitative assessment method to evaluate the impact and guide management to develop mitigation measures. We provide a method to estimate the sensitivity of benthic habitats based on the longevity composition of the invertebrate community. We hypothesize that long-lived species are more sensitive to trawling mortality due to their lower pace of life (i.e. slower growth, late maturation). We analyse data from box-core and grab samples taken from 401 stations in the English Channel and southern North Sea to estimate the habitat-specific longevity composition of the benthic invertebrate community and of specific functional groups (i...
April 20, 2018: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/29678889/stress-control-for-a-well-structured-life
#4
David C Goldstone, Edward N Baker
Aerobic life brings with it a need to respond to external redox stress in ways that preserve key processes. <u>S</u>uppressor of <u>c</u>opper <u>s</u>ensitivity (Scs) proteins contribute to this response in some bacteria, but have poorly defined molecular functions. Furlong et al. now demonstrate that two Scs proteins from Proteus mirabilis provide a redox relay functionally equivalent to, but structurally distinct from, the Dsb proteins that orchestrate disulfide bonding in Escherichia coli , emphasizing the wide prevalence of this mechanism in bacteria...
April 20, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29678754/sex-and-age-dependent-effects-of-orexin-1-receptor-blockade-on-open-field-behavior-and-neuronal-activity
#5
Shannon R Blume, Hannah Nam, Sandra Luz, Debra A Bangasser, Seema Bhatnagar
Adolescence is a sensitive and critical period in brain development where psychiatric disorders such as anxiety, depression and post-traumatic stress disorder are more likely to emerge following a stressful life event. Females are two times more likely to suffer from psychiatric disorders than males. Patients with these disorders show alterations in orexins (also called hypocretins), important neuropeptides that regulate arousal, wakefulness and the hypothalamic-pituitary-adrenal axis activity. Little is known on the role of orexins in mediating arousal behaviors in male and female rats during adolescence or adulthood...
April 17, 2018: Neuroscience
https://www.readbyqxmd.com/read/29678726/corticosterone-profiles-in-northern-cardinals-cardinalis-cardinalis-do-levels-vary-through-life-history-stages
#6
Benjamin M Duckworth, Jodie M Jawor
As animals move through life history stages, energy requirements for each stage will vary. Both daily and annual variation in the glucocoriticoid hormones (specifically corticosterone, or CORT, in birds) helps provide the variable energy needed through life history stages. In many bird species, CORT is higher in the breeding season when energy demands can be quite high and is often lower in the non-breeding season. Additionally, CORT has a role to play in the response to stressful stimuli and the level to which CORT is elevated following stressful events can vary through the annual cycle as well...
April 17, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29677680/transcriptomic-identification-of-salt-related-genes-and-de-novo-assembly-in-common-buckwheat-f-esculentum
#7
Qi-Huan Lu, Ya-Qi Wang, Jin-Nan Song, Hong-Bing Yang
Common buckwheat (F. esculentum), annually herbaceous crop, is prevalent in people's daily life with the increasing development of economics. Compared with wheat, it is highly praised with high content of rutin and flavonoid. Common buckwheat is recognized as healthy food with good taste, and the product price of which such as noodles, flour, bread and so on are higher than wheat, and the seeds of which are bigger than that of tartary buckwheat, so if common buckwheat are planted more widely, people will spend less money on this healthy and delicious food...
April 4, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29677638/gestational-glucocorticoid-exposure-disrupts-glucose-homeostasis-that-is-accompanied-by-increased-endoglin-and-dpp-4-activity-instead-of-gsk-3-in-rats
#8
Olufunto O Badmus, Olugbenga S Michael, Saheed Rabiu, Lawrence A Olatunji
Gestational glucocorticoid (GC) treatment has been associated with cardiometabolic disorder (CMD) in offspring's in later life. Elevated dipeptidyl peptidase-4 (DPP-4) activity, endoglin and glycogen synthase kinase-3 (GSK-3) has also been implicated in the development of insulin resistance (IR) and/or vascular inflammation. We aimed to investigate the impact of GC exposure on glucose metabolism and the circulating levels of inflammatory biomarkers, DPP-4 activity and GSK-3 in pregnant rats. Pregnant Wistar rats received either vehicle or dexamethasone (DEX; 0...
April 13, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29677398/does-stress-increase-risk-of-breast-cancer-a-15-year-prospective-study
#9
Phyllis Butow, Melanie Price, Joseph Coll, Katherine Tucker, Bettina Meiser, Roger Milne, Judith Wilson, Louise Heiniger, Brandi Baylock, Tracey Bullen, Prue Weideman, Kelly-Anne Phillips
OBJECTIVE: The possible impact of stress on cancer incidence remains controversial. We prospectively evaluated associations between life event stressors, social support, personality characteristics (optimism, anger control, anti-emotionality) and risk of developing primary breast cancer (BCa), in women at increased familial risk of BCa. METHODS: A prospective cohort, repeated measures design was employed. Recruitment was through the Kathleen Cuningham Foundation Consortium for Research into Familial breast cancer (kConFab), which collects genetic, epidemiological and clinical data from Australasian families with multiple BCa cases...
April 20, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29677034/functional-somatic-symptoms-across-cultures-perceptual-and-health-care-issues
#10
Bernd Löwe, Christian Gerloff
Functional neurological disorders are conceptualized as patterns of neurological symptoms that cannot be attributed to a clear organic etiology. The study by Wilkins et al. published in this issue of Psychosomatic Medicine, revealed that 8.2% of patients who were initially presented with suspected stroke were later diagnosed with functional disorders, i.e., "functional stroke mimics." However, the percentage of functional stroke mimics varied substantially with patients' nationality, age, and sex...
April 19, 2018: Psychosomatic Medicine
https://www.readbyqxmd.com/read/29677027/surgery-complications-and-quality-of-life-a-longitudinal-cohort-study-exploring-the-role-of-psychosocial-factors
#11
Stephanie Archer, Anna Pinto, Sabine Vuik, Colin Bicknell, Omar Faiz, Ben Byrne, Maximilian Johnston, Petros Skapinakis, Thanos Athanasiou, Charles Vincent, Ara Darzi
OBJECTIVE: To determine whether psychosocial factors moderate the relationship between surgical complications and quality of life (QoL). BACKGROUND: Patients who experience surgical complications have significantly worse postoperative QoL than patients with an uncomplicated recovery. Psychosocial factors, such as coping style and level of social support influence how people deal with stressful events, but it is unclear whether they affect QoL following a surgical complication...
April 19, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29676640/a-pilot-study-assessing-the-ability-of-5-aminosalicylic-acid-to-modulate-the-immune-response-in-chronic-beryllium-disease
#12
Brian J Day, Jie Huang, Briana Q Barkes, May Gillespie, Li Li, Lisa A Maier
Chronic beryllium disease is a granulomatous lung disease, characterized by the accumulation of macrophages and beryllium-specific CD4+ T-cells that proliferate and produce T-helper cell type 1 cytokines. Previous studies indicate that beryllium-mediated oxidative stress enhances cytokine response in chronic beryllium disease CD4+ T-cells. 5-Aminosalicylic acid (5-ASA) is currently used to treat inflammatory bowel disease and has both antioxidant and antiinflammatory actions. We hypothesized that 5-ASA therapy may be a beneficial therapy in chronic beryllium disease...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29676530/short-and-long-term-changes-in-health-related-quality-of-life-with-weight-loss-results-from-a-randomized-controlled-trial
#13
Rebecca L Pearl, Thomas A Wadden, Jena Shaw Tronieri, Robert I Berkowitz, Ariana M Chao, Naji Alamuddin, Sharon M Leonard, Raymond Carvajal, Zayna M Bakizada, Emilie Pinkasavage, Kathryn A Gruber, Olivia A Walsh, Nasreen Alfaris
OBJECTIVE: The objective of this study was to determine the effects of weight loss and weight loss maintenance (WLM) on weight-specific health-related quality of life in a 66-week trial. METHODS: Adults with obesity (N = 137, 86.1% female, 68.6% black, mean age = 46.1 years) who had lost ≥ 5% of initial weight in a 14-week intensive lifestyle intervention/low-calorie diet (LCD) program were randomly assigned to lorcaserin or placebo for an additional 52-week WLM program...
April 20, 2018: Obesity
https://www.readbyqxmd.com/read/29676393/corrigendum-to-association-of-stressful-life-events-with-psychological-problems-a-large-scale-community-based-study-using-grouped-outcomes-latent-factor-regression-with-latent-predictors
#14
Akbar Hassanzadeh, Zahra Heidari, Awat Feizi, Ammar Hassanzadeh Keshteli, Hamidreza Roohafza, Hamid Afshar, Payman Adibi
[This corrects the article DOI: 10.1155/2017/3457103.].
2018: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/29675841/early-life-conditions-that-impact-song-learning-in-male-zebra-finches-also-impact-neural-and-behavioral-responses-to-song-in-females
#15
Kendra B Sewall, Rindy C Anderson, Jill A Soha, Susan Peters, Stephen Nowicki
Early life stressors can impair song in songbirds by negatively impacting brain development and subsequent learning. Even in species in which only males sing, early life stressors might also impact female behavior and its underlying neural mechanisms, but fewer studies have examined this possibility. We manipulated brood size in zebra finches to simultaneously examine the effects of developmental stress on male song learning and female behavioral and neural response to song. Although adult male HVC volume was unaffected, we found that males from larger broods imitated tutor song less accurately...
April 20, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29675586/rapamycin-alleviates-hormone-imbalance-induced-chronic-nonbacterial-inflammation-in-rat-prostate-through-activating-autophagy-via-the-mtor-ulk1-atg13-signaling-pathway
#16
Yang Su, Jingxiao Lu, Xianguo Chen, Chaozhao Liang, Pengcheng Luo, Cong Qin, Jie Zhang
Chronic prostatitis (CP) is a clinically common disease with high morbidity. It affects the patients' quality of life (QoL) as well as physical and mental health seriously due to the recurring symptoms of lower urinary tract and genitalia. As the opinions about the etiology of CP are still not uniform, it is very difficult to be treated or even cured. Autophagy is a highly conserved physiological function which is widely found in eukaryotic cells. In general, cells maintain a certain level of autophagy under physiological conditions, and the basal level of autophagy can be regulated by a variety of autophagy-related genes under stress such as hunger, infection, trauma, and other circumstances...
April 19, 2018: Inflammation
https://www.readbyqxmd.com/read/29675264/blocking-negative-effects-of-senescence-in-human-skin-fibroblasts-with-a-plant-extract
#17
Ingo Lämmermann, Lucia Terlecki-Zaniewicz, Regina Weinmüllner, Markus Schosserer, Hanna Dellago, André Dargen de Matos Branco, Dominik Autheried, Benjamin Sevcnikar, Lisa Kleissl, Irina Berlin, Frédérique Morizot, Francois Lejeune, Nicola Fuzzati, Sandra Forestier, Alix Toribio, Anaïs Tromeur, Lionel Weinberg, Juan Carlos Higareda Almaraz, Marcel Scheideler, Marion Rietveld, Abdoel El Ghalbzouri, Erwin Tschachler, Florian Gruber, Johannes Grillari
There is increasing evidence that senescent cells are a driving force behind many age-related pathologies and that their selective elimination increases the life- and healthspan of mice. Senescent cells negatively affect their surrounding tissue by losing their cell specific functionality and by secreting a pro-tumorigenic and pro-inflammatory mixture of growth hormones, chemokines, cytokines and proteases, termed the senescence-associated secretory phenotype (SASP). Here we identified an extract from the plant Solidago virgaurea subsp...
2018: NPJ Aging and Mechanisms of Disease
https://www.readbyqxmd.com/read/29674991/when-teams-fail-to-self-regulate-predictors-and-outcomes-of-team-procrastination-among-debating-teams
#18
Edwin A J Van Hooft, Heleen Van Mierlo
Models of team development have indicated that teams typically engage in task delay during the first stages of the team's life cycle. An important question is to what extent this equally applies to all teams, or whether there is variation across teams in the amount of task delay. The present study introduces the concept of team procrastination as a lens through which we can examine whether teams collectively engage in unplanned, voluntary, and irrational delay of team tasks. Based on theory and research on self-regulation, team processes, and team motivation we developed a conceptual multilevel model of predictors and outcomes of team procrastination...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29674980/decision-making-in-suicidal-behavior-the-protective-role-of-loss-aversion
#19
Gergö Hadlaczky, Sebastian Hökby, Anahit Mkrtchian, Danuta Wasserman, Judit Balazs, Núria Machín, Marco Sarchiapone, Merike Sisask, Vladimir Carli
Background: Loss aversion is a central and well operationalized trait behavior that describes the tendency for humans to strongly prefer avoiding losses to making equivalent gains. Human decision-making is thus biased toward safer choices. Aim: The aim of this study was to explore the relationship between loss aversion and suicidal behavior in a large cohort of adolescents recruited in 30 schools of seven European countries for a longitudinal study (Current Controlled Trials ISRCTN65120704)...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29674944/dunye-guanxinning-improves-acute-myocardial-ischemia-reperfusion-injury-by-inhibiting-neutrophil-infiltration-and-caspase-1-activity
#20
Q G Zhang, S R Wang, X M Chen, H N Guo, S Ling, J W Xu
Acute myocardial infarction is the most serious manifestation of cardiovascular disease, and it is a life-threatening condition. Dunye Guanxinning (DG) is a protective traditional Chinese patent herbal medicine with high clinical efficacy and suitable for the treatment of myocardial infarction. However, the mechanism through which it is beneficial is unclear. In this study, we hypothesized that DG improves acute myocardial ischemia-reperfusion injury by inhibiting neutrophil infiltration and caspase-1 activity...
2018: Mediators of Inflammation
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