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https://www.readbyqxmd.com/read/29774939/-feasibility-and-preliminary-technical-experience-of-single-incision-plus-one-port-laparoscopic-total-gastrectomy-combined-with-%C3%AF-shaped-esophagojejunal-anastomosis-in-surgical-treatment-of-gastric-cancer
#1
Guangsheng Du, Enlai Jiang, Yuan Qiu, Wensheng Wang, Shuai Wang, Yunbo Li, Ke Peng, Xiang Li, Hua Yang, Weidong Xiao
OBJECTIVE: To explore the feasibility, safety, and preliminary technical experience of single incision plus one port laparoscopic total gastrectomy combined with π-shaped esophagojejunal anastomosis (SILT-π) in the surgical treatment of gastric cancer. METHODS: Clinical data of 5 gastric cancer patients undergoing SILT-π operation at the Department of General Surgery, The Second Affiliated Hospital of the Army Medical University from August to October 2017 were retrospectively analyzed...
May 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29771081/-analysis-of-related-factors-of-coins-foreign-bodies-crossing-the-esophagus-in-204-cases-of-children
#2
H L Lv, B Yan, Q H Zhang
Objective: To explore the anti-tumor effect of Stat3 antisense oligodeoxynucleotide on human Hep-2 cell tumor-bearing BALB/c nude mouse, to study the therapeutic value of Stat3 antisense oligodeoxynucleotide on laryngeal cancer. Method: Hep-2 cells from human laryngeal carcinoma in logarithmic phase were inoculated subcutaneously into BALB/c mice to establish a model of human Hep-2 cell tumor-bearing BALB/c mice. They were divided into blank group, control group and different concentrations of AS3 groups(1 group, 2 group, 3 group, 4 group), and then intraperitoneally administered once a day for 4 weeks, measuring body weight twice a week, and the long and short diameters of the tumors were recorded...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29768280/phase-i-ii-trial-of-chemotherapy-with-docetaxel-cisplatin-and-s-1-for-unresectable-advanced-squamous-cell-carcinoma-of-the-esophagus
#3
Toshiyasu Ojima, Masaki Nakamura, Mikihito Nakamori, Masahiro Katsuda, Keiji Hayata, Shimpei Maruoka, Toshio Shimokawa, Hiroki Yamaue
Our previous trial with a docetaxel, cisplatin, and 5-fluorouracil (DCF) regimen showed high response rates in metastatic squamous cell carcinoma of the esophagus (SCCE). The observed increased toxicity of the DCF regimen, however, was clinically harmful. S-1, an oral anticancer drug, has been approved as a combination therapy for SCCE, and alternate-day regimen with S-1 has shown lower levels of toxicity. This prospective single-center phase I/II trial examines the efficacy and toxicity of a combination of docetaxel, cisplatin, and an alternate-day regimen of S-1 (modified DCS) for patients with metastatic SCCE...
May 16, 2018: Oncology
https://www.readbyqxmd.com/read/29766306/intraoperative-conversion-does-not-affect-the-oncological-outcomes-of-minimally-invasive-esophagectomy-for-treatment-of-esophageal-cancer
#4
Xue-Hai Liu, Yi Hu, Kun-Kun Li, Ying-Jian Wang, Yao-Guang Jiang, Wei Guo
BACKGROUND: The aim of this study is to summarize the causes and implications of intraoperative conversion from minimally invasive esophagectomy (MIE) to open thoracotomy, and to evaluate the effect on long-term survival. METHODS: There were 293 thoracoscopic esophagectomies for esophageal squamous cell carcinoma (ESCC) of the thoracic esophagus performed by the authors from September 2009 to August 2015. Totally, 257 patients were enrolled in this study. These patients were divided into two groups (those underwent complete MIE and those converted to open thoracotomy) and then compared...
May 15, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29765265/is-volumetric-modulated-arc-therapy-with-constant-dose-rate-a-valid-option-in-radiation-therapy-for-head-and-neck-cancer-patients
#5
Annamaria Didona, Valentina Lancellotta, Claudio Zucchetti, Bianca Moira Panizza, Alessandro Frattegiani, Martina Iacco, Anna Concetta Di Pilato, Simonetta Saldi, Cynthia Aristei
Background: Intensity-modulated radiotherapy (IMRT) improves dose distribution in head and neck (HN) radiation therapy. Volumetric-modulated arc therapy (VMAT), a new form of IMRT, delivers radiation in single or multiple arcs, varying dose rates (VDR-VMAT) and gantry speeds, has gained considerable attention. Constant dose rate VMAT (CDR-VMAT) associated with a fixed gantry speed does not require a dedicated linear accelerator like VDR-VMAT. The present study explored the feasibility, efficiency and delivery accuracy of CDR-VMAT, by comparing it with IMRT and VDR-VMAT in treatment planning for HN cancer...
May 2018: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/29764015/-treatment-and-prognosis-of-264-patients-with-hypopharyngeal-carcinoma
#6
W Xu, Z H Lyu, N Sa, J K Ma, J J Tian, S H Feng, P Cui, H Y Cao
Objective: To investigate the key factors influencing the prognosis of hypopharyngeal carcinoma and the therapeutic methods improving the efficacy of treatments for hypopharyngeal carcinoma. Methods: Two hundred and sixty-four cases of hypopharyngeal squamous cell carcinoma treated from May 2010 to May 2015 were analyzed retrospectively. There were 211 cases of pyriform sinus carcinoma, 37 cases of posterior pharyngeal wall carcinoma, and 16 cases of postcricoid carcinoma. According to UICC 2002 criteria, 2 cases were for stage Ⅰ, 14 for stage Ⅱ, 32 for stage Ⅲ and 216 for stage Ⅳ...
May 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29759332/sunset-stereotactic-radiation-for-ultracentral-non-small-cell-lung-cancer-a-safety-and-efficacy-trial
#7
Meredith Giuliani, Ashwathy S Mathew, Houda Bahig, Scott V Bratman, Edith Filion, Daniel Glick, Alexander V Louie, Srinivas Raman, Anand Swaminath, Andrew Warner, Vivian Yau, David Palma
BACKGROUND: Lung stereotactic body radiotherapy (SBRT) is considered a standard curative treatment for medically inoperable early stage non-small-cell lung cancer (NSCLC). Patients with ultracentral tumors (signifying tumors whose planning target volume touches or overlaps the central bronchial tree, esophagus, or pulmonary artery) may be at higher risk of serious toxicities such as bronchial stricture and collapse, esophageal strictures, tracheal-esophageal fistula, and hemorrhage. The primary objective of the study is to determine the maximum tolerated dose of radiotherapy for ultracentral NSCLC...
April 18, 2018: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29757780/effects-of-intraoperative-opioid-use-on-recurrence-free-and-overall-survival-in-patients-with-esophageal-adenocarcinoma-and-squamous-cell-carcinoma
#8
Kim N Du, Lei Feng, Abigail Newhouse, Jeel Mehta, Javier Lasala, Gabriel E Mena, Wayne L Hofstetter, Juan P Cata
BACKGROUND: Perioperative opioid use is associated with poor survival in patients with esophageal squamous cell carcinoma. The most common histological type of esophageal cancer in western countries is adenocarcinoma. The objective of this study was to evaluate the association between intraoperative opioid consumption and survival in patients with adenocarcinoma and squamous cell carcinoma of the esophagus. METHODS: Records of patients who had undergone esophageal cancer surgery between January 2000 and January 2017 were reviewed...
May 10, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29753503/novel-esophageal-reconstruction-technique-via-transmediastinal-route-from-posterior-to-anterior-mediastinum-after-esophagectomy
#9
Takushi Yasuda, Osamu Shiraishi, Mitsuru Iwama, Tomoki Makino, Hiroaki Kato, Yutaka Kimura
BACKGROUND: The incidence of metachronous esophageal squamous cell cancer (ESCC) after head and neck cancer (HNC) and in elderly patients has increased. Both elderly ESCC patients and ESCC patients after HNC surgery are at potential risk for dysphagia, and for the latter, surgery in the neck is difficult. An intrathoracic anastomosis that bypasses the cervical procedure is preferable to preserve swallowing function and reduce surgical risk. In gastrectomized patients, because the stomach cannot be used as a substitute, securing graft blood supply is critical, but microvascular anastomosis cannot be easily added in procedures for intrathoracic posterior mediastinal reconstruction...
April 13, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29752721/can-endoscopic-resection-for-barrett-s-dysplasia-and-early-cancer-be-curative
#10
REVIEW
Shai Friedland, George Triadafilopoulos
Effective endoscopic treatments for dysplasia and early (intramucosal) cancer, together with expanded and rigorous screening programs to detect Barrett's esophagus, could help reverse the increase in the incidence of esophageal cancer and reduce esophageal cancer-related mortality. In this review, we discuss the long-term outcomes for mucosal resection for dysplasia and early cancer and compares them to esophagectomy as the standard of care choice. Eendoscopic resection for Barrett's dysplasia and early cancer can be curative but only when the lesion can be classified as: Paris type I (polypoid); Paris IIa (slightly elevated); Paris IIb (flat); Paris IIc (slightly depressed); histological grades G1 and G2; high-grade dysplasia...
May 11, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29752155/a-retrospective-study-of-treatment-for-curative-synchronous-double-primary-cancers-of-the-head-and-neck-and-the-esophagus
#11
Tabito Okamoto, Chikatoshi Katada, Shouko Komori, Keishi Yamashita, Shunsuke Miyamoto, Koichi Kano, Yutomo Seino, Hiroshi Hosono, Hiroki Matsuba, Hiromitsu Moriya, Mitsuhiro Sugawara, Mizutomo Azuma, Hiromichi Ishiyama, Satoshi Tanabe, Kazushige Hayakawa, Wasaburo Koizumi, Makito Okamoto, Taku Yamashita
OBJECTIVE: Curative synchronous double primary cancers of the head and neck and the esophagus (CSC-HE) are frequently detected, but a standard treatment remains to be established. We studied the clinical course to explore appropriate treatment strategies. METHODS: We retrospectively studied consecutive 33 patients who had CSC-HE. The disease stage was classified into 4 groups: group A, early head and neck cancer (HNC) and early esophageal cancer (EC); group B, early HNC and advanced EC; group C, advanced HNC and early EC; and group D, advanced HNC and advanced EC...
May 8, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29751076/tobacco-specific-nitrosamines-a-literature-review
#12
Evangelia Konstantinou, Foteini Fotopoulou, Athanasios Drosos, Nektaria Dimakopoulou, Zoi Zagoriti, Athanasios Niarchos, Dimitra Makrynioti, Dimitrios Kouretas, George Lagoumintzis, Konstantinos Poulas
Cigarette smoke is a complex mixture of chemicals, including several tobacco-specific nitrosamines (TSNA). Most TSNA are formed in tobacco during the post-harvest period, while a number are produced when a cigarette is burned. Considerable evidence supports the role of TSNA important causative factors for cancers of the lung, pancreas, esophagus, and oral cavity in people who use tobacco products. Of the known TSNA, nicotine-derived nitrosamine ketone (NNK) and N-nitrosonornicotine (NNN) are the most carcinogenic...
May 8, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29749499/stable-silencing-of-dll4-gene-suppresses-the-growth-and-metastasis-of-esophagus-cancer-cells-by-attenuating-akt-phosphorylation
#13
Xianzhi Guo, Yingchun Duan, Xiaolei Ye, Lina Hu, Tong Xu, Li Tong, Minghua Yu
δ‑Like ligand 4 (DLL4) has recently been reported to be involved in the process of cancer angiogenesis and considered to play a vital role in vascular endothelial growth factor (VEGF) signaling, while the role of DLL4 in cancer metastasis and growth has not been systematically studied. In the present study, the esophagus cancer cell line Eca109 was infected in vitro with a lentiviral vector loaded with dll4‑shRNA to obtain a stable cell line of DLL4 expression which was downregulated through puromycin screening...
May 8, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29749320/combined-treatment-for-gastric-cancer-immunological-approach
#14
Olzhas Zhandossov, Galina Kaussova, Avraam Koten
BACKGROUND/AIMS: Gastric cancer is one of the most common oncological diseases. It can develop in any part of the stomach and spread to other organs, especially the esophagus, lungs, and liver. The aim of our study was to investigate the effectiveness of our proposed therapy. MATERIALS AND METHODS: Our research promises more effective neoadjuvant therapy, including immunotherapy and multi-agent chemotherapy. Of the 62 patients involved in our study, 32 underwent neoadjuvant chemotherapy in combination with surgery, whereas the rest underwent neoadjuvant chemoimmunotherapy with surgery...
March 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29739803/centrosome-amplification-arises-before-neoplasia-and-increases-upon-p53-loss-in-tumorigenesis
#15
Carla A M Lopes, Marta Mesquita, Ana Isabel Cunha, Joana Cardoso, Sara Carapeta, Cátia Laranjeira, António E Pinto, José B Pereira-Leal, António Dias-Pereira, Mónica Bettencourt-Dias, Paula Chaves
Centrosome abnormalities are a typical hallmark of human cancers. However, the origin and dynamics of such abnormalities in human cancer are not known. In this study, we examined centrosomes in Barrett's esophagus tumorigenesis, a well-characterized multistep pathway of progression, from the premalignant condition to the metastatic disease. This human cancer model allows the study of sequential steps of progression within the same patient and has representative cell lines from all stages of disease. Remarkably, centrosome amplification was detected as early as the premalignant condition and was significantly expanded in dysplasia...
May 8, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29733012/robotic-approach-in-benign-and-malignant-esophageal-tumors-a-preliminary-seven-case-series
#16
Victor Tomulescu, Codrut Stanescu, Cristian Blajut, Loredana Barbulescu, Gabriela Droc, Vlad Herlea, Irinel Popescu
Esophageal surgery has been recognized as very challenging for surgeons and risky for patients. Thoracoscopic approach have proved its benefit in esophageal surgery but has some drawbacks as tremor and limited degrees of freedom, contra-intuitive movements and fulcrum effect of the surgical tools. Robotic technology has been developed with the intent to overcome these limitations of the standard laparoscopy or thoracoscopy. These benefits of robotic procedure are most advantageous when operating in remote areas difficult to reach as in esophageal surgery...
March 2018: Chirurgia
https://www.readbyqxmd.com/read/29732341/comparison-and-evaluation-of-different-treatment-plans-with-ifrt-field-and-6-and-18-mv-energies-in-hodgkin-s-lymphoma-involvement-neck-and-mediastinum
#17
M B Tavakoli, M Maleki, A Akhavan, T Hadisinia, I Abedi, A Amouheidari
Background: Radiotherapy with large mantle field is an effective technique in increasing the risk of secondary cancers among HL (Hodgkin Lymphoma) patients; therefore, it is essential to choose an effective treatment field including the least medical conditions in radiotherapy. Objective: The present study aimed to plan separate fields for neck and mediastinum using various energies, to compare dose distribution with MLC and to block field formation. Materials and Methods: In this study, 3D conformal treatments, Siemens Oncor accelerator equipped with multi-leaf collimator (MLC) were performed to create anterior-posterior fields...
March 2018: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/29730913/-clinic-features-and-prognostic-analysis-for-t1-esophagus-cancer
#18
Z Yu, X M Li, M Huai, G J Lu, C Wang, Q Y Wang, Q Y Liu
Objective: To investigate relationship between the clinicopathological features and prognosis of T1 esophageal carcinoma. Methods: Data from 212 T1 primary esophageal cancer patients, who underwent radical surgery in The Fourth Hospital of Hebei Medical University from Jan 2001 to Dec 2009 were enrolled. There were 148 males and 64 females. There were 91 patients with stage pT1a and 121 patients with stage pT1b. Results: The survival of the 212 patients was 27~108 months, and the median survival was 80.8 months...
April 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29730811/phlegmonous-gastritis-associated-with-advanced-esophageal-cancer
#19
Nobutoshi Hagiwara, Takeshi Matsutani, Hiroki Umezawa, Munenaga Nakamizo, Kazuhiko Yokoshima, Eriko Shinozuka, Tsutomu Nomura, Eiji Uchida
Phlegmonous gastritis is a rapidly progressive bacterial infection of the stomach wall. It has a high mortality rate and aggressive treatment, either with antibiotics or surgical resection, is required. Here, we report an extremely rare case of phlegmonous gastritis associated with advanced esophageal cancer. A 65-year-old Japanese man was urgently admitted to the hospital due to pyrexia and gastrointestinal symptoms. Abdominal computed tomography revealed widespread diffuse thickening of the gastric wall. On endoscopic examination, an ulcerative mass was detected at the lower thoracic esophagus, and a markedly elevated submucosal lesion was present in the middle of the stomach body...
May 5, 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29729227/metformin-and-risk-of-developing-nasopharyngeal-cancer-in-patients-with-type-2-diabetes-mellitus
#20
Chin-Hsiao Tseng
BACKGROUND: Metformin has anticancer effects, but whether it can reduce the risk of nasopharyngeal cancer (NPC) is not known. METHODS: A total of 15,486 ever-users and 15,486 never-users of metformin matched by propensity score were enrolled from among patients with new-onset type 2 diabetes mellitus diagnosed during the period 1999-2005 and who were found in the reimbursement database of Taiwan's National Health Insurance. The patients were followed until December 31, 2011...
May 2, 2018: Metabolism: Clinical and Experimental
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