Savas T Tsikis, Thomas I Hirsch, Timothy Klouda, Scott C Fligor, Amy Pan, Malachi M Joiner, Sarah Z Wang, Mikayla Quigley, Angela Devietro, Paul D Mitchell, Hiroko Kishikawa, Ke Yuan, Mark Puder
Neonates with congenital diaphragmatic hernia (CDH) frequently require cardiopulmonary bypass and systemic anticoagulation. We previously demonstrated that even subtherapeutic heparin impairs lung growth and function in a murine model of compensatory lung growth. The direct thrombin inhibitors (DTIs) bivalirudin and argatroban preserved growth in this model. While DTIs are increasingly used for systemic anticoagulation clinically, CDH patients may still receive heparin. In this experiment, lung endothelial cell proliferation was assessed following treatment with heparin-alone or mixed with increasing concentrations of bivalirudin or argatroban...
December 19, 2023: American Journal of Physiology. Lung Cellular and Molecular Physiology