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Lsd1 heart

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https://www.readbyqxmd.com/read/24275769/aldosterone-s-mechanism-of-action-roles-of-lysine-specific-demethylase-1-caveolin-and-striatin
#1
REVIEW
Rene Baudrand, Luminita H Pojoga, Jose R Romero, Gordon H Williams
PURPOSE OF REVIEW: Aldosterone's functions and mechanisms of action are different depending on the tissue and the environmental condition. The mineralocorticoid receptor is present in tissues beyond epithelial cells, including the heart and vessels. Furthermore, aldosterone has direct adverse effects by both genomic and rapid/nongenomic actions not only through a nuclear receptor but also through caveolae-mediated intracellular events. Also, multiple environmental-genetic interactions play an important role in salt-sensitive hypertension (SSH) and aldosterone modulation...
January 2014: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/23721412/protein-recognition-by-short-peptide-reversible-inhibitors-of-the-chromatin-modifying-lsd1-corest-lysine-demethylase
#2
Marcello Tortorici, Maria Teresa Borrello, Maria Tardugno, Laurent R Chiarelli, Simona Pilotto, Giuseppe Ciossani, Nadeem A Vellore, Sarah G Bailey, Jonathan Cowan, Maria O'Connell, Simon J Crabb, Graham Packham, Antonello Mai, Riccardo Baron, A Ganesan, Andrea Mattevi
The combinatorial assembly of protein complexes is at the heart of chromatin biology. Lysine demethylase LSD1(KDM1A)/CoREST beautifully exemplifies this concept. The active site of the enzyme tightly associates to the N-terminal domain of transcription factors of the SNAIL1 family, which therefore can competitively inhibit the binding of the N-terminal tail of the histone substrate. Our enzymatic, crystallographic, spectroscopic, and computational studies reveal that LSD1/CoREST can bind to a hexapeptide derived from the SNAIL sequence through recognition of a positively charged α-helical turn that forms upon binding to the enzyme...
August 16, 2013: ACS Chemical Biology
https://www.readbyqxmd.com/read/23637775/a-hypomorphic-lsd1-allele-results-in-heart-development-defects-in-mice
#3
Thomas B Nicholson, Anup K Singh, Hui Su, Sarah Hevi, Jing Wang, Jeff Bajko, Mei Li, Reginald Valdez, Margaret Goetschkes, Paola Capodieci, Joseph Loureiro, Xiaodong Cheng, En Li, Bernd Kinzel, Mark Labow, Taiping Chen
Lysine-specific demethylase 1 (Lsd1/Aof2/Kdm1a), the first enzyme with specific lysine demethylase activity to be described, demethylates histone and non-histone proteins and is essential for mouse embryogenesis. Lsd1 interacts with numerous proteins through several different domains, most notably the tower domain, an extended helical structure that protrudes from the core of the protein. While there is evidence that Lsd1-interacting proteins regulate the activity and specificity of Lsd1, the significance and roles of such interactions in developmental processes remain largely unknown...
2013: PloS One
https://www.readbyqxmd.com/read/22491473/retraction-defective-heart-development-in-hypomorphic-lsd1-mice
#4
Thomas B Nicholson, Hui Su, Sarah Hevi, Jing Wang, Jeff Bajko, Mei Li, Reginald Valdez, Joseph Loureiro, Xiaodong Cheng, En Li, Bernd Kinzel, Mark Labow, Taiping Chen
No abstract text is available yet for this article.
April 10, 2012: Cell Research
https://www.readbyqxmd.com/read/22143567/defective-heart-development-in-hypomorphic-lsd1-mice
#5
Thomas B Nicholson, Hui Su, Sarah Hevi, Jing Wang, Jeff Bajko, Mei Li, Reginald Valdez, Joseph Loureiro, Xiaodong Cheng, En Li, Bernd Kinzel, Mark Labow, Taiping Chen
Lysine-specific demethylase 1 (LSD1/AOF2/KDM1A), the first enzyme with specific lysine demethylase activity to be described, demethylates histone and non-histone proteins and is essential for mouse embryogenesis. LSD1 interacts with numerous proteins through several different domains, most notably the tower domain, an extended helical structure that protrudes from the core of the protein. While there is evidence that LSD1-interacting proteins regulate the activity and specificity of LSD1, the significance and roles of such interactions in developmental processes remain largely unknown...
December 6, 2011: Cell Research
https://www.readbyqxmd.com/read/21873498/histone-demethylase-lsd1-deficiency-during-high-salt-diet-is-associated-with-enhanced-vascular-contraction-altered-no-cgmp-relaxation-pathway-and-hypertension
#6
Luminita H Pojoga, Jonathan S Williams, Tham M Yao, Abhinav Kumar, Joseph D Raffetto, Graciliano R A do Nascimento, Ossama M Reslan, Gail K Adler, Gordon H Williams, Yujiang Shi, Raouf A Khalil
Histone methylation, a determinant of chromatin structure and gene transcription, was thought to be irreversible, but recent evidence suggests that lysine-specific demethylase-1 (LSD1, Kdm1a) induces demethylation of histone H3 lysine 4 (H3K4) or H3K9 and thereby alters gene transcription. We previously demonstrated a human LSD1 phenotype associated with salt-sensitive hypertension. To test the hypothesis that LSD1 plays a role in the regulation of blood pressure (BP) via vascular mechanisms and gene transcription, we measured BP and examined vascular function and endothelial nitric oxide (NO) synthase (eNOS) expression in thoracic aorta of male wild-type (WT) and heterozygous LSD1 knockout mice (LSD1(+/-)) fed either a liberal salt (HS; 4% NaCl) or restricted salt diet (LS; 0...
November 2011: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/21799893/improvement-of-cardiac-function-in-mouse-myocardial-infarction-after-transplantation-of-epigenetically-modified-bone-marrow-progenitor-cells
#7
Johnson Rajasingh, Jayakumar Thangavel, Mohammad R Siddiqui, Ignatius Gomes, Xiao-pei Gao, Raj Kishore, Asrar B Malik
OBJECTIVE: To study usefulness of bone marrow progenitor cells (BPCs) epigenetically altered by chromatin modifying agents in mediating heart repair after myocardial infarction in mice. METHODS AND RESULTS: We tested the therapeutic efficacy of bone marrow progenitor cells treated with the clinically-used chromatin modifying agents Trichostatin A (TSA, histone deacetylase inhibitor) and 5Aza-2-deoxycytidine (Aza, DNA methylation inhibitor) in a mouse model of acute myocardial infarction (AMI)...
2011: PloS One
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