keyword
MENU ▼
Read by QxMD icon Read
search

Prazosin PTSD

keyword
https://www.readbyqxmd.com/read/27828694/efficacy-of-prazosin-in-posttraumatic-stress-disorder-a-systematic-review-and-meta-analysis
#1
Balwinder Singh, Andrew J Hughes, Gaurav Mehta, Patricia J Erwin, Ajay K Parsaik
OBJECTIVE: To consolidate the evidence from the literature to evaluate the role of prazosin in the treatment of posttraumatic stress disorder (PTSD). DATA SOURCES: Major databases, including PubMed, Ovid EMBASE, Ovid Cochrane Central Register of Controlled Trials, Ovid Cochrane Database of Systematic Reviews, Ovid PsycINFO, and Scopus, were searched through August 2015 for studies reporting the role of prazosin in the treatment of PTSD with no language constraints...
July 28, 2016: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/27822278/prazosin-for-trauma-nightmares-and-sleep-disturbances-in-combat-veterans-with-post-traumatic-stress-disorder
#2
Habibolah Khazaie, Marzie Nasouri, Mohammad Rasoul Ghadami
BACKGROUND: Prazosin is significantly effective to reduce sleep disturbance and trauma nightmare in patients with post-traumatic stress disorder (PTSD); however, results of different studies were evaluated. OBJECTIVES: The current randomized clinical trial aimed to assess the effects of prazosin on sleep parameters and nightmares among veterans with chronic PTSD. MATERIALS AND METHODS: Thirty-two veterans with chronic war-induced PTSD and distressing nightmares were randomized into prazosin and placebo groups for eight weeks...
September 2016: Iranian Journal of Psychiatry and Behavioral Sciences
https://www.readbyqxmd.com/read/27703791/initiation-of-pharmacotherapy-for-post-traumatic-stress-disorder-among-veterans-from-iraq-and-afghanistan-a-dimensional-symptom-cluster-approach
#3
Ilan Harpaz-Rotem, Robert Rosenheck, Somaia Mohamed, Robert Pietrzak, Rani Hoff
BACKGROUND: The pharmacological treatment of post-traumatic stress disorder (PTSD) is extremely challenging, as no specific agent has been developed exclusively to treat this disorder. Thus, there are growing concerns among the public, providers and consumers associated with its use as the efficacy of some agents is still in question. AIMS: We applied a dimensional and symptom cluster-based approach to better understand how the heterogeneous phenotypic presentation of PTSD may relate to the initiation of pharmacotherapy for PTSD initial episode...
September 2016: BJPsych Open
https://www.readbyqxmd.com/read/27667865/evidence-for-using-doxazosin-in-the-treatment-of-posttraumatic-stress-disorder
#4
Cherish Smith, Maju Mathew Koola
There is evidence that doxazosin is effective in the treatment of posttraumatic stress disorder (PTSD). Doxazosin is a "me-too" drug of prazosin. Doxazosin has an improved absorption profile and this likely minimizes the risk for unintended adverse hypotensive effects. The availability of doxazosin in the gastrointestinal therapeutic system (GITS) form permits a higher initial daily dose (4 mg/day) while avoiding significant first-dose side effects. The treatment of PTSD with prazosin has several disadvantages due to its short duration of action (6-8 hours), which results in multiple doses being required...
2016: Psychiatric Annals
https://www.readbyqxmd.com/read/27432823/traitement-des-%C3%A3-tats-de-stress-post-traumatiques-par-un-antagoniste-alpha-1-adr%C3%A3-nergique-la-prazosine-une-revue-des-%C3%A3-tudes-d-%C3%A3-valuation
#5
Philippe Yves Rémy Simon, Pierre-François Rousseau
OBJECTIVE: The present review aims to assess the clinical efficacy and safety of the α-1-adrenergic antagonist prazosin as primary pharmacologic treatment for post-traumatic stress disorder (PTSD). METHOD: A systematic review was performed using keywords (i.e., prazosin, α-1-adrenergic antagonist, α-1-blocker, post-traumatic stress disorder) in the databases PubMed/Medline (1966-May 2016), Embase (1966-May 2016), ScienceDirect (1823-May 2016), OvidSP (1946-May 2016) and Nature (1845-May 2016)...
July 18, 2016: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/27320368/higher-pretreatment-blood-pressure-is-associated-with-greater-posttraumatic-stress-disorder-symptom-reduction-in-soldiers-treated-with-prazosin
#6
Murray A Raskind, Steven P Millard, Eric C Petrie, Kris Peterson, Tammy Williams, David J Hoff, Kimberly Hart, Hollie Holmes, Jeffrey Hill, Colin Daniels, Rebecca Hendrickson, Elaine R Peskind
BACKGROUND: In a previously reported positive randomized controlled trial of the α1-adrenoreceptor (α1AR) antagonist prazosin for combat posttraumatic stress disorder (PTSD) in 67 active duty soldiers, baseline symptoms did not predict therapeutic response. If increased brain α1AR activation in PTSD is the target of prazosin treatment action, higher brain α1AR activation should predict greater prazosin efficacy. Although brain α1AR activation is not measurable, coregulated peripheral α1AR activation could provide an estimate of brain α1AR activation...
November 15, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27276365/doxazosin-an-%C3%AE-1-adrenergic-receptor-antagonist-for-nightmares-in-patients-with-posttraumatic-stress-disorder-and-or-borderline-personality-disorder-a-chart-review
#7
S Roepke, H Danker-Hopfe, D Repantis, B Behnia, F Bernard, M-L Hansen, C Otte
Objective: Centrally active α-1-adrenergic-receptor antagonists such as prazosin are effective in the treatment of nightmares in patients with posttraumatic stress disorder (PTSD). A pharmacological alternative is doxazosin, which has a longer half-life and fewer side effects. However, doxazosin is currently being used without solid empirical evidence. Furthermore, no study so far has assessed the effects of α-1-antagonists on nightmares in patients with borderline personality disorder (BPD). We retrospectively assessed the effectiveness of doxazosin on nightmares in PTSD and BPD...
June 8, 2016: Pharmacopsychiatry
https://www.readbyqxmd.com/read/27249080/doxazosin-xl-reduces-symptoms-of-posttraumatic-stress-disorder-in-veterans-with-ptsd-a-pilot-clinical-trial
#8
Christopher Rodgman, Christopher D Verrico, Manuela Holst, Daisy Thompson-Lake, Colin N Haile, Richard De La Garza, Murray A Raskind, Thomas F Newton
BACKGROUND: Serotonin and norepinephrine reuptake inhibitors are effective first-line agents for the treatment of posttraumatic stress disorder (PTSD), but treatment is associated with a range of side effects that limit treatment adherence. Prazosin, an α1-noradrenergic antagonist with a half-life of roughly 2-3 hours, has shown promise in the treatment of sleep disturbance and nightmares. Doxazosin extended release (XL) is also an α1-noradrenergic antagonist but with a half-life of approximately 15-19 hours...
May 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27222130/noradrenergic-dysregulation-in-the-pathophysiology-of-ptsd
#9
Rebecca C Hendrickson, Murray A Raskind
A central role for noradrenergic dysregulation in the pathophysiology of post-traumatic stress disorder (PTSD) is increasingly suggested by both clinical and basic neuroscience research. Here, we integrate recent findings from clinical and animal research with the earlier literature. We first review the evidence for net upregulation of the noradrenergic system and its responsivity to stress in individuals with PTSD. Next, we trace the evidence that the α1 noradrenergic receptor antagonist prazosin decreases many of the symptoms of PTSD from initial clinical observations, to case series, to randomized controlled trials...
May 21, 2016: Experimental Neurology
https://www.readbyqxmd.com/read/27138076/medical-approach-to-the-management-of-traumatized-refugees
#10
J David Kinzie
Refugees are a highly traumatized and culturally diverse group of patients who present many clinical challenges. Refugees have a high prevalence of traumas from torture, ethnic cleansing, and the effects of long civil wars. The most common diagnoses associated with the effects of such traumas are posttraumatic stress disorder (PTSD) or PTSD with comorbid depression; however, psychosis and neurocognitive disorders are also common. For those with PTSD, a suggested treatment approach is long-term supportive psychotherapy with drug treatment directed at reducing the most disruptive symptoms, such as insomnia, nightmares, and irritability or psychosis...
March 2016: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/26900667/two-case-reports-on-use-of-prazosin-for-drug-dreams
#11
Ganesh Gopalakrishna, Oluwole Popoola, Austin Campbell, Marina A Nemetalla
Substance abuse and dependence is estimated to cost roughly $700 billion annually including direct and indirect care in the United States. Drug dreams (DD), or using dreams, are a reportedly common phenomenon among patients with substance abuse, and have been postulated as triggers for relapse. Prazosin is an alpha-1 receptor antagonist originally approved by the United States Food and Drug Administration for the treatment of hypertension. Prazosin passes the blood brain barrier easily, contributing to central and cognitive effects...
March 2016: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/26856810/pharmacology-for-sleep-disturbance-in-ptsd
#12
Gosia Lipinska, David S Baldwin, Kevin G F Thomas
Symptoms of sleep disturbance, particularly nightmares and insomnia, are a central feature of post-traumatic stress disorder (PTSD). Emerging evidence suggests that specific treatment of PTSD-related sleep disturbance improves other symptoms of the disorder, which in turn suggests that such disturbance may be fundamental to development and maintenance of the disorder. This mini-review focuses on pharmacological treatment of sleep disturbance in adult PTSD (specifically, studies testing the efficacy of antidepressants, adrenergic inhibiting agents, antipsychotics and benzodiazepine and non-benzodiazepine hypnotics)...
March 2016: Human Psychopharmacology
https://www.readbyqxmd.com/read/26844999/help-desk-answers-is-prazosin-effective-for-ptsd-associated-nightmares
#13
Nina Abul-Husn, Adam Kipp, Emily Looney, Todd Palmer
No abstract text is available yet for this article.
December 2015: Journal of Family Practice
https://www.readbyqxmd.com/read/26835889/meta-analysis-of-the-efficacy-and-safety-of-prazosin-versus-placebo-for-the-treatment-of-nightmares-and-sleep-disturbances-in-adults-with-posttraumatic-stress-disorder
#14
Kirsten C George, Lisa Kebejian, Leigh J Ruth, Christopher W T Miller, Seth Himelhoch
UNLABELLED: Although sleep disturbances occur commonly in patients with posttraumatic stress disorder (PTSD) and are associated with adverse outcomes and increased suicidality, they are often inadequately addressed by antidepressant medications. OBJECTIVE: This review aims to assess whether prazosin reduces nightmares, sleep disturbances, and illness severity in adults with PTSD. METHOD: Electronic databases (PubMed, PsycINFO) were searched in September 2014 for randomized controlled trials in adults...
July 2016: Journal of Trauma & Dissociation
https://www.readbyqxmd.com/read/26683790/prazosin-for-veterans-with-posttraumatic-stress-disorder-and-comorbid-alcohol-dependence-a-clinical-trial
#15
RANDOMIZED CONTROLLED TRIAL
Ismene L Petrakis, Nitigna Desai, Ralitza Gueorguieva, Albert Arias, Erin O'Brien, J Serrita Jane, Kevin Sevarino, Steven Southwick, Elizabeth Ralevski
BACKGROUND: Posttraumatic stress disorder (PTSD) is an important and timely clinical issue particularly for combat veterans. Few pharmacologic options are available to treat PTSD, particularly among military personnel, and they are not based on rational neurobiology. The evidence for noradrenergic dysregulation in PTSD is strong, and the alpha-adrenergic agonist prazosin is one of the most promising medications to treat sleep disturbances associated with PTSD as well as PTSD symptoms among both veterans and civilians...
January 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/26644317/prazosin-for-treating-sleep-disturbances-in-adults-with-posttraumatic-stress-disorder-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#16
Davit Khachatryan, Dianne Groll, Linda Booij, Amir A Sepehry, Christian G Schütz
OBJECTIVE: Posttraumatic stress disorder (PTSD) is a disorder with significant sleep morbidity and limited treatment options. Prazosin may constitute a novel management approach and has been tested recently in a number of trials. We conducted a meta-analysis to examine the effectiveness of prazosin for nightmares and other sleep disturbances in adults with PTSD. METHOD: A systematic review of databases for randomized, double-blind, placebo-controlled trials of adults diagnosed with PTSD and reporting sleep disturbances that were treated with prazosin was conducted in January 2015...
March 2016: General Hospital Psychiatry
https://www.readbyqxmd.com/read/26437180/geographical-diffusion-of-prazosin-across-veterans-health-administration-examination-of-regional-variation-in-daily-dosing-and-quality-indicators-among-veterans-with-posttraumatic-stress-disorder
#17
Thad E Abrams, Brian C Lund, Bruce Alexander, Nancy C Bernardy, Matthew J Friedman
Posttraumatic stress disorder (PTSD) is a high-priority treatment area for the Veterans Health Administration (VHA), and dissemination patterns of innovative, efficacious therapies can inform areas for potential improvement of diffusion efforts and quality prescribing. In this study, we replicated a prior examination of the period prevalence of prazosin use as a function of distance from Puget Sound, Washington, where prazosin was first tested as an effective treatment for PTSD and where prazosin use was previously shown to be much greater than in other parts of the United States...
2015: Journal of Rehabilitation Research and Development
https://www.readbyqxmd.com/read/26132915/putative-dopamine-agonist-kb220z-attenuates-lucid-nightmares-in-ptsd-patients-role-of-enhanced-brain-reward-functional-connectivity-and-homeostasis-redeeming-joy
#18
Thomas McLaughlin, Kenneth Blum, Marlene Oscar-Berman, Marcelo Febo, Gozde Agan, James L Fratantonio, Thomas Simpatico, Mark S Gold
BACKGROUND: Lucid dreams are frequently pleasant and training techniques have been developed to teach dreamers to induce them. In addition, the induction of lucid dreams has also been used as a way to ameliorate nightmares. On the other hand, lucid dreams may be associated with psychiatric conditions, including Post-Traumatic Stress Disorder (PTSD) and Reward Deficiency Syndrome-associated diagnoses. In the latter conditions, lucid dreams can assume an unpleasant and frequently terrifying character...
June 2015: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/26035198/early-discontinuation-and-suboptimal-dosing-of-prazosin-a-potential-missed-opportunity-for-veterans-with-posttraumatic-stress-disorder
#19
Bruce Alexander, Brian C Lund, Nancy C Bernardy, Melissa L D Christopher, Matthew J Friedman
OBJECTIVE: Clinical Practice Guidelines issued by the US Department of Veterans Affairs (VA) and the Department of Defense recommend prazosin for sleep/nightmares for veterans with posttraumatic stress disorder (PTSD). As existing literature suggests this novel treatment option to be underutilized, we examined a cohort of veterans with PTSD initiating prazosin to characterize their typical duration of use and dosing patterns. METHOD: Administrative data from fiscal year 2010 were used to identify veterans with PTSD according to ICD-9 codes extracted from inpatient and outpatient encounters...
May 2015: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/25970279/terazosin-for-the-treatment-of-trauma-related-nightmares-a-report-of-4-cases
#20
Anjali Nirmalani-Gandhy, Deborah Sanchez, Glenn Catalano
The selective α1-adrenergic antagonist prazosin has been shown in multiple studies to be effective in targeting trauma-related nightmares in posttraumatic stress disorder. There are limited data regarding the effectiveness of another selective α1-adrenergic antagonist terazosin for the treatment of trauma-related nightmares. We present 4 cases in which terazosin was effectively used to treat nightmares as a second-line agent after prazosin failure. Further studies are needed to validate terazosin as an alternative to prazosin for the treatment of posttraumatic stress disorder-related nightmares...
May 2015: Clinical Neuropharmacology
keyword
keyword
20634
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"