Matt Ulgherait, Anna Chen, Sophie F McAllister, Han X Kim, Rebecca Delventhal, Charlotte R Wayne, Christian J Garcia, Yocelyn Recinos, Miles Oliva, Julie C Canman, Martin Picard, Edward Owusu-Ansah, Mimi Shirasu-Hiza
Because old age is associated with defects in circadian rhythm, loss of circadian regulation is thought to be pathogenic and contribute to mortality. We show instead that loss of specific circadian clock components Period (Per) and Timeless (Tim) in male Drosophila significantly extends lifespan. This lifespan extension is not mediated by canonical diet-restriction longevity pathways but is due to altered cellular respiration via increased mitochondrial uncoupling. Lifespan extension of per mutants depends on mitochondrial uncoupling in the intestine...
April 21, 2020: Nature Communications