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https://www.readbyqxmd.com/read/28314066/comparison-of-propeller-perforator-flap-and-venous-supercharged-propeller-perforator-flap-in-reconstruction-of-lower-limb-soft-tissue-defect-a-prospective-study
#1
Benoit Chaput, Nicolas Bertheuil, Jean-Louis Grolleau, Farid Bekara, Raphael Carloni, Jerome Laloze, Christian Herlin
INTRODUCTION: In lower limbs, reliability of propeller perforator flaps (PPF) remains uncertain. The main complication is venous congestion, which can lead to distal necrosis. We aim to highlight if venous supercharging of PPF could substantially limit complications in lower limb coverage. METHODS: Between 2011 and 2016, we developed a standardized procedure of venous supercharging in the lower limb reconstruction with PPF using saphenous veins anastomosis. Then, we prospectively compared a consecutive series of 30 PPF to cover lower limbs defect, with a consecutive series of 30 venous-supercharged PPF (vsPPF)...
March 17, 2017: Microsurgery
https://www.readbyqxmd.com/read/28296177/fibromyalgia-remains-a-significant-burden-in-rheumatoid-arthritis-patients-in-australia
#2
Anthea C Gist, Emma K Guymer, Laura E Eades, Michelle Leech, Geoffrey O Littlejohn
AIM: High rates of fibromyalgia (FM) are reported in rheumatoid arthritis (RA) patients. Advances in RA management have occurred, but information regarding current significance of FM in RA is limited. This investigation estimated the prevalence and health effects of concomitant FM in Australian RA patients. METHODS: Participants were recruited from Australian rheumatology clinics. Subjects were assessed using the 1990 and 2011 American College of Rheumatology (ACR) FM criteria and the polysymptomatic distress score (PDS) was calculated...
March 13, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28293509/free-flap-salvage-after-recurrent-venous-thrombosis-by-means-of-large-scale-treatment-with-medical-leeches
#3
Kensuke Tashiro, Masahide Fujiki, Masaki Arikawa, Yu Kagaya, Shimpei Miyamoto
An anterolateral thigh flap was salvaged using 110 medical leeches in the absence of an available vein for reanastomosis. After surgical construction of the flap for full-thickness thoracic wall reconstruction, the patient developed complete venous occlusion. Specifically, the anastomotic vein developed complete occlusion, and the internal jugular vein had a thrombus. In addition, because the lung was posterior to the flap, the angiogenic area of the flap was very small. When the medical leeches were first applied, the flap showed prominent venous congestion...
December 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28290215/genetic-assessment-of-leech-species-from-yak-bos-grunniens-in-the-tract-of-northeast-india
#4
Nilkantha Chatterjee, Bishal Dhar, Debasis Bhattarcharya, Sourabh Deori, Juwar Doley, Joken Bam, Pranab J Das, Asit K Bera, Sitangshu M Deb, Ningthoujam Neelima Devi, Rajesh Paul, Sorokhaibam Malvika, Sankar Kumar Ghosh
Yak is an iconic symbol of Tibet and high altitudes of Northeast India. It is highly cherished for milk, meat, and skin. However, yaks suffer drastic change in milk production, weight loss, etc, when infested by parasites. Among them, infestation by leeches is a serious problem in the Himalayan belt of Northeast India. The parasite feeds on blood externally or from body orifices, like nasopharynx, oral, rectum, etc. But there has been limited data about the leech species infesting the yak in that region because of the difficulties in morphological identification due to plasticity of the body, changes in shape, and surface structure and thus, warrants for the molecular characterization of leech...
March 14, 2017: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/28288700/externally-induced-frontoparietal-synchronization-modulates-network-dynamics-and-enhances-working-memory-performance
#5
Ines R Violante, Lucia M Li, David W Carmichael, Romy Lorenz, Robert Leech, Adam Hampshire, John C Rothwell, David J Sharp
Cognitive functions such as working memory (WM) are emergent properties of large-scale network interactions. Synchronisation of oscillatory activity might contribute to WM by enabling the coordination of long-range processes. However, causal evidence for the way oscillatory activity shapes network dynamics and behavior in humans is limited. Here we applied transcranial alternating current stimulation (tACS) to exogenously modulate oscillatory activity in a right frontoparietal network that supports WM. Externally induced synchronization improved performance when cognitive demands were high...
March 14, 2017: ELife
https://www.readbyqxmd.com/read/28269138/statistical-identification-of-stimulus-activated-network-nodes-in-multi-neuron-voltage-sensitive-dye-optical-recordings
#6
Elham Fathiazar, Jorn Anemuller, Jutta Kretzberg
Voltage-Sensitive Dye (VSD) imaging is an optical imaging method that allows measuring the graded voltage changes of multiple neurons simultaneously. In neuroscience, this method is used to reveal networks of neurons involved in certain tasks. However, the recorded relative dye fluorescence changes are usually low and signals are superimposed by noise and artifacts. Therefore, establishing a reliable method to identify which cells are activated by specific stimulus conditions is the first step to identify functional networks...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28263617/training-preschoolers-prospective-abilities-through-conversation-about-the-extended-self
#7
Nadia Chernyak, Kathryn A Leech, Meredith L Rowe
The ability to act on behalf of one's future self is related to uniquely human abilities such as planning, delay of gratification, and goal attainment. Although prospection develops rapidly during early childhood, little is known about the mechanisms that support its development. Here we explored whether encouraging children to talk about their extended selves (self outside the present context) boosts their prospective abilities. Preschoolers (N = 81) participated in a 5-min interaction with an adult in which they were asked to talk about events in the near future, distant future, near past, or present...
April 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28258081/increased-brain-predicted-aging-in-treated-hiv-disease
#8
James H Cole, Jonathan Underwood, Matthan W A Caan, Davide De Francesco, Rosan A van Zoest, Robert Leech, Ferdinand W N M Wit, Peter Portegies, Gert J Geurtsen, Ben A Schmand, Maarten F Schim van der Loeff, Claudio Franceschi, Caroline A Sabin, Charles B L M Majoie, Alan Winston, Peter Reiss, David J Sharp
OBJECTIVE: To establish whether HIV disease is associated with abnormal levels of age-related brain atrophy, by estimating apparent brain age using neuroimaging and exploring whether these estimates related to HIV status, age, cognitive performance, and HIV-related clinical parameters. METHODS: A large sample of virologically suppressed HIV-positive adults (n = 162, age 45-82 years) and highly comparable HIV-negative controls (n = 105) were recruited as part of the Comorbidity in Relation to AIDS (COBRA) collaboration...
March 3, 2017: Neurology
https://www.readbyqxmd.com/read/28255315/in-silico-designing-of-a-new-cysteine-analogue-of-hirudin-variant-3-for-site-specific-pegylation
#9
Seyed Mehdi Sajjadi, Hamzeh Rahimi, Saeed Mohammadi, Mohammad Faranoush, Hasan Mirzahoseini, Gholamreza Toogeh
Hirudin is an anticoagulant agent of the salivary glands of the medicinal leech. Recombinant hirudin (r-Hir) displays certain drawbacks including bleeding and immunogenicity. To solve these problems, cysteine-specific PEGylation has been proposed as a successful technique. However, proper selection of the appropriate cysteine residue for substitution is a critical step. This study has, for the first time, used a computational approach aimed at identifying a single potential PEGylation site for replacement by cysteine residue in the hirudin variant 3 (HV3)...
February 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28254980/transcriptome-sequence-of-the-bloodstream-form-of-trypanoplasma-borreli-a-hematozoic-parasite-of-fish-transmitted-by-leeches
#10
Mark Carrington, Eva Dóró, Maria Forlenza, Geert F Wiegertjes, Steven Kelly
Here, we report a transcriptome sequence of Trypanoplasma borreli isolated from its natural host, the common carp, Cyprinus carpio The transcriptome allows an analysis of abundant cell surface proteins and acts as a comparator for understanding the evolution and pathogenicity of other Kinetoplastida, including several that infect humans.
March 2, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28236531/neuroadaptive-bayesian-optimization-and-hypothesis-testing
#11
REVIEW
Romy Lorenz, Adam Hampshire, Robert Leech
Cognitive neuroscientists are often interested in broad research questions, yet use overly narrow experimental designs by considering only a small subset of possible experimental conditions. This limits the generalizability and reproducibility of many research findings. Here, we propose an alternative approach that resolves these problems by taking advantage of recent developments in real-time data analysis and machine learning. Neuroadaptive Bayesian optimization is a powerful strategy to efficiently explore more experimental conditions than is currently possible with standard methodology...
February 13, 2017: Trends in Cognitive Sciences
https://www.readbyqxmd.com/read/28227367/statistical-identification-of-stimulus-activated-network-nodes-in-multi-neuron-voltage-sensitive-dye-optical-recordings
#12
Elham Fathiazar, Jorn Anemuller, Jutta Kretzberg, Elham Fathiazar, Jorn Anemuller, Jutta Kretzberg, Elham Fathiazar, Jutta Kretzberg, Jorn Anemuller
Voltage-Sensitive Dye (VSD) imaging is an optical imaging method that allows measuring the graded voltage changes of multiple neurons simultaneously. In neuroscience, this method is used to reveal networks of neurons involved in certain tasks. However, the recorded relative dye fluorescence changes are usually low and signals are superimposed by noise and artifacts. Therefore, establishing a reliable method to identify which cells are activated by specific stimulus conditions is the first step to identify functional networks...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28213068/an-unusual-cause-of-severe-dyspnea-a-laryngeal-live-leech-case-report
#13
Said Anajar, Rachid Ansari, Jawad Hassnaoui, Reda Abada, Mohammed Roubal, Mohammed Mahtar
INTRODUCTION: Foreign bodies in the upper airways are one of the most challenging otolaryngology emergencies, leeches present a very rare cause of airway foreign bodies around the world. CASE REPORT: A 6-year-old girl was referred to our otolaryngology department at a tertiary university hospital with a severe dyspnea and hemoptysis. Nasofibroscopy revealed a dark living leech in the supraglottic area which extends to the glottis. The patient was urgently admitted to the operating room, the leech was grasped and removed with a foreign body forceps with a full length of more than 6cm...
January 25, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28196661/pediatric-medical-device-development-by-surgeons-via-capstone-engineering-design-programs
#14
Bryan S Sack, Rodolfo A Elizondo, Gene O Huang, Nicolette Janzen, Jimmy Espinoza, Magdalena Sanz-Cortes, Jennifer E Dietrich, Julie Hakim, Eric Richardson, Maria Oden, John Hanks, Balakrishna Haridas, James F Hury, Chester J Koh
BACKGROUND: There is a need for pediatric medical devices that accommodate the unique physiology and anatomy of pediatric patients that is increasingly receiving more attention. However, there is limited literature on the programs within children's hospitals and academia that can support pediatric device development. We describe our experience with pediatric device design utilizing collaborations between a children's hospital and two engineering schools. METHODS: Utilizing the academic year as a timeline, unmet pediatric device needs were identified by surgical faculty and matched with an engineering mentor and a team of students within the Capstone Engineering Design programs at two universities...
February 6, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28193332/analysis-of-agaricus-meleagris-pyranose-dehydrogenase-n-glycosylation-sites-and-performance-of-partially-non-glycosylated-enzymes
#15
Christoph Gonaus, Daniel Maresch, Katharina Schropp, Peter Ó Conghaile, Dónal Leech, Lo Gorton, Clemens K Peterbauer
Pyranose Dehydrogenase 1 from the basidiomycete Agaricus meleagris (AmPDH1) is an oxidoreductase capable of oxidizing a broad variety of sugars. Due to this and its ability of dioxidation of substrates and no side production of hydrogen peroxide, it is studied for use in enzymatic bio-fuel cells. In-vitro deglycosylated AmPDH1 as well as knock-out mutants of the N-glycosylation sites N(75) and N(175), near the active site entrance, were previously shown to improve achievable current densities of graphite electrodes modified with AmPDH1 and an osmium redox polymer acting as a redox mediator, up to 10-fold...
April 2017: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/28179347/dose-sparing-potential-of-deep-inspiration-breath-hold-technique-for-left-breast-cancer-radiotherapy-organs-at-risk
#16
Gavin Lawler, Michelle Leech
BACKGROUND/AIM: To assess if deep inspiration breath-hold (DIBH) technique achieved dose sparing for organs-at-risk in left breast radiotherapy patients in order to reduce long-term complications. PATIENTS AND METHODS: DIBH and Free-breathing (FB) as a control, CT planning scans obtained for 28 left breast/chest wall (+/- supraclavicular field) patients treated January 2008-December 2013 were retrospectively re-contoured and re-planned. Organs-at-risk examined: lungs, left lung, heart and left anterior descending coronary artery (LADCA)...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28169287/il-10-producing-st2-expressing-foxp3-t-cells-in-multiple-sclerosis-brain-lesions
#17
Stephanie Elizabeth Johanna Zandee, Richard Anthony O'Connor, Iris Mair, Melanie Dawn Leech, Anna Williams, Stephen Mark Anderton
CD4(+)Foxp3(+) T regulatory (Treg) cells provide a key defence against inflammatory disease, but also have an ability to produce pro-inflammatory cytokines. The evidence for these two possibilities in multiple sclerosis (MS) is controversial. However, this has largely been based on studies of circulating Treg cells derived from peripheral blood, rather than the central nervous system. We show that Foxp3(+) cells in the brains of MS patients predominantly produce interleukin-10 (IL-10) and show high expression of the IL-33 receptor ST2 (associated with potent Treg function), indicating that Treg in the inflamed brain maintain their suppressive function...
February 7, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28167629/il-10-plays-opposing-roles-during-staphylococcus-aureus-systemic-and-localized-infections
#18
John M Leech, Keenan A Lacey, Michelle E Mulcahy, Eva Medina, Rachel M McLoughlin
IL-10 is a potent anti-inflammatory mediator that plays a crucial role in limiting host immunopathology during bacterial infections by controlling effector T cell activation. Staphylococcus aureus has previously been shown to manipulate the IL-10 response as a mechanism of immune evasion during chronic systemic and biofilm models of infection. In the present study, we demonstrate divergent roles for IL-10 depending on the site of infection. During acute systemic S. aureus infection, IL-10 plays an important protective role and is required to prevent bacterial dissemination and host morbidity by controlling effector T cells and the associated downstream hyperactivation of inflammatory phagocytes, which are capable of host tissue damage...
March 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28166454/potential-reservoirs-and-risk-factors-for-vhsv-ivb-in-an-enzootic-system-budd-lake-michigan
#19
Elizabeth Throckmorton, Travis Brenden, Amber K Peters, Tammy J Newcomb, Gary E Whelan, Mohamed Faisal
Viral hemorrhagic septicemia virus genotype IVb (VHSV IVb) has caused major, sporadic fish die-offs in the Laurentian Great Lakes region of North America since 2005. Presently, factors affecting VHSV IVb persistence in enzootic systems are not well understood. Even with annual surveillance, the virus can go undetected for several years after an outbreak before again re-emerging, which suggests that the virus is maintained in the system either below detectable levels or in untested reservoirs. The aim of this study was to identify potential reservoirs of VHSV IVb in Budd Lake, Michigan; VHSV IVb was first detected in Budd Lake in 2007 but remained undetected until 2011...
March 2017: Journal of Aquatic Animal Health
https://www.readbyqxmd.com/read/28156040/bioelectrochemical-haber-bosch-process-an-ammonia-producing-h2-n2-fuel-cell
#20
Ross D Milton, Rong Cai, Sofiene Abdellaoui, Dónal Leech, Antonio L De Lacey, Marcos Pita, Shelley D Minteer
Nitrogenases are the only enzymes known to reduce molecular nitrogen (N2 ) to ammonia (NH3 ). By using methyl viologen (N,N'-dimethyl-4,4'-bipyridinium) to shuttle electrons to nitrogenase, N2 reduction to NH3 can be mediated at an electrode surface. The coupling of this nitrogenase cathode with a bioanode that utilizes the enzyme hydrogenase to oxidize molecular hydrogen (H2 ) results in an enzymatic fuel cell (EFC) that is able to produce NH3 from H2 and N2 while simultaneously producing an electrical current...
March 1, 2017: Angewandte Chemie
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