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https://www.readbyqxmd.com/read/29456985/evaluation-of-mir-21-inhibition-and-its-impact-on-cancer-susceptibility-candidate-2-long-noncoding-rna-in-colorectal-cancer-cell-line
#1
Miganoosh Simonian, Mohammadreza Sharifi, Reza Nedaeinia, Meysam Mosallaie, Sharifeh Khosravi, Amir Avan, Majid Ghayour-Mobarhan, Hadi Bagheri, Rasoul Salehi
Background: Both microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) have been shown to have a critical role in the regulation of cellular processes such as cell growth and apoptosis, as well as cancer progression and metastasis. lncRNAs are aberrantly expressed in many diseases including cancer. Although it is well known that miRNAs can target a large number of protein-coding genes, little is known whether miRNAs can also target lncRNAs. In the present study, we determine whether miR-21 can regulate lncRNA cancer susceptibility candidate 2 (CASC2) in colorectal cancer...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29456199/the-liver-first-approach-for-synchronous-colorectal-liver-metastases-more-than-a-decade-of-experience-in-a-single-centre
#2
Mechteld C de Jong, Rianne C J Beckers, Victor van Woerden, Julie M L Sijmons, Marc H A Bemelmans, Ronald M van Dam, Cornelis H C Dejong
BACKGROUND: The feasibility of the liver-first approach for synchronous colorectal liver metastases (CRLM) has been established. We sought to assess the short-term and long-term outcomes for these patients. METHODS: Outcomes of patients who underwent a liver-first approach for CRLM between 2005 and 2015 were retrospectively evaluated from a prospective database. RESULTS: Of the 92 patients planned to undergo the liver-first strategy, the paradigm could be completed in 76...
February 15, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29455841/actual-10-year-survival-after-hepatic-resection-of-colorectal-liver-metastases-what-factors-preclude-cure
#3
John M Creasy, Eran Sadot, Bas Groot Koerkamp, Joanne F Chou, Mithat Gonen, Nancy E Kemeny, Vinod P Balachandran, T Peter Kingham, Ronald P DeMatteo, Peter J Allen, Leslie H Blumgart, William R Jarnagin, Michael I D'Angelica
BACKGROUND: Hepatic resection of colorectal liver metastases is associated with long-term survival. This study analyzes actual 10-year survivors after resection of colorectal liver metastases, reports the observed rate of cure, and identifies factors that preclude cure. METHODS: A single-institution, prospectively maintained database was queried for all initial resections for colorectal liver metastases for the years 1992-2004. Observed cure was defined as actual 10-year survival with either no recurrence or resected recurrence with at least 3 years of disease-free follow-up...
February 15, 2018: Surgery
https://www.readbyqxmd.com/read/29455637/molecular-dynamics-of-interaction-of-sesamin-and-related-compounds-with-the-cancer-marker-%C3%AE-catenin-an-in-silico-study
#4
Bindu Madhuri Cavuturu, Vishwambar Vishnu Bhandare, Amutha Ramaswamy, Neelakantan Arumugam
By virtue of their regulatory role in the biological process, certain protein-protein complexes form potential targets for designing and discovery of drugs. Alteration set in the controlled formation of such complexes results in dysregulation of several metabolic processes, leading to diseased condition. β-catenin/Tcf4 complex is one such protein-protein complex found altered in colorectal epithelial cells resulting in activation of target genes leading to cancer. Recently certain lignans from seeds of the oil crop sesame were found inhibiting initiation and progression of this type of cancer...
February 18, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29452968/analysis-and-description-of-disease-specific-quality-of-life-in-patients-with-anal-fistula
#5
Manuel Ferrer-Márquez, Natalia Espínola-Cortés, Ángel Reina-Duarte, José Granero-Molina, Cayetano Fernández-Sola, José Manuel Hernández-Padilla
INTRODUCTION: In patients diagnosed with anal fistula, knowing the quality of life specifically related to the disease can help coloproctology specialists to choose the most appropriate therapeutic strategy for each case. The aim of our study is to analyzse and describe the factors related to the specific quality of life in a consecutive series of patients diagnosed with anal fistula. METHODS: Observational, cross-sectional study carried out from March 2015 to February 2017...
February 13, 2018: Cirugía Española
https://www.readbyqxmd.com/read/29451037/esophageal-hiatal-hernia-risk-diagnosis-and-management
#6
Hai-Xiang Yu, Chun-Shan Han, Jin-Ru Xue, Zhi-Feng Han, Hua Xin
Esophageal hiatal hernia involves abnormal abdominal entry into thoracic cavity. It is classified based on orientation between esophageal junction and diaphragm. Sliding hiatal hernia (Type-I) comprises the most frequent category, emanating from right crus of diaphragm. Type-II esophageal hernia engages both left and right muscular crura. Type-III and IV additionally include the left crus. Age and increased body mass index are key risk factors, and congenital skeletal aberrations trigger pathogenesis through intestinal malrotations...
February 16, 2018: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29450468/activity-and-safety-of-cetuximab-plus-modified-folfoxiri-followed-by-maintenance-with-cetuximab-or-bevacizumab-for-ras-and-braf-wild-type-metastatic-colorectal-cancer-a-randomized-phase-2-clinical-trial
#7
Chiara Cremolini, Carlotta Antoniotti, Sara Lonardi, Giuseppe Aprile, Francesca Bergamo, Gianluca Masi, Roberta Grande, Giuseppe Tonini, Claudia Mescoli, Giovanni Gerardo Cardellino, Luigi Coltelli, Lisa Salvatore, Domenico Cristiano Corsi, Cristiana Lupi, Donatello Gemma, Monica Ronzoni, Emanuela Dell'Aquila, Federica Marmorino, Francesca Di Fabio, Maria Laura Mancini, Lorenzo Marcucci, Gabriella Fontanini, Vittorina Zagonel, Luca Boni, Alfredo Falcone
Importance: The combination of a triple-drug chemotherapy regimen with an anti-epidermal growth factor receptor (EGFR) agent as a first-line treatment of metastatic colorectal cancer (mCRC) showed promising activity along with safety concerns in single-arm phase 2 trials. The role of maintenance following chemotherapy and anti-EGFR and the optimal regimen to be adopted are not established. Objectives: To evaluate the activity and safety of cetuximab plus modified FOLFOXIRI (mFOLFOXIRI) and explore the role of maintenance with cetuximab or bevacizumab in RAS and BRAF wild-type mCRC...
February 15, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29449807/atrial-natriuretic-peptide-acts-as-a-neuroprotective-agent-in-in-vitro-models-of-parkinson-s-disease-via-up-regulation-of-the-wnt-%C3%AE-catenin-pathway
#8
Arianna Colini Baldeschi, Eugenia Pittaluga, Federica Andreola, Simona Rossi, Mauro Cozzolino, Giuseppe Nicotera, Gianluca Sferrazza, Pasquale Pierimarchi, Annalucia Serafino
In the last decades increasing evidence indicated a crucial role of the Wnt/β-catenin signaling in development of midbrain dopaminergic (mDA) neurons. Recently dysregulation of this pathway has been proposed as a novel pathomechanism leading to Parkinson's disease (PD) and some of the molecules participating to the signaling have been evaluated as potential therapeutic targets for PD. Atrial natriuretic peptide (ANP) is a cardiac-derived hormone having a critical role in cardiovascular homeostasis. ANP and its receptors (NPRs) are widely expressed in mammalian central nervous system (CNS) where they could be implicated in the regulation of neural development, synaptic transmission and information processing, as well as in neuroprotection...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29449725/iatrogenic-colorectal-kaposi-s-sarcoma-complicating-a-refractory-ulcerative-colitis-in-a-human-immunodeficiency-negative-virus-patient
#9
L Chtourou, L Ayedi, H Rejab, M Boudabous, L Mnif, A Grati, T Boudaouara, R Mzali, A Amouri, N Tahri
Kaposi sarcoma is an unusual tumor associated to a human herpes virus-8 infection involving the skin or internal organs. Iatrogenic Kaposi's sarcoma often occurs in patients receiving immunosuppressive therapy. So far, a few Kaposi's sarcoma cases have been reported in the literature associated with inflammatory bowel diseases. We report a 53-year-old male diagnosed with a severe refractory ulcerative colitis who was treated with corticosteroids and azathioprine. The patient underwent a colectomy after the failure of medical treatment...
December 2017: Pathologica
https://www.readbyqxmd.com/read/29448312/prognostic-significance-of-poorly-differentiated-clusters-and-tumor-budding-in-colorectal-liver-metastases
#10
Gilton M Fonseca, Evandro S de Mello, Sheila F Faraj, Jaime A P Kruger, Fabricio F Coelho, Vagner B Jeismann, Renato M Lupinacci, Ivan Cecconello, Venancio A F Alves, Timothy M Pawlik, Paulo Herman
BACKGROUND: Histomorphological features have been described as prognostic factors after resection of colorectal liver metastases (CLM). The objectives of this study were to assess the prognostic significance of tumor budding (TB) and poorly differentiated clusters (PDC) among CLM, and their association with other prognostic factors. METHODS: We evaluated 229 patients who underwent a first resection of CLM. Slides stained by HE were assessed for TB, PDC, tumor border pattern, peritumoral pseudocapsule, peritumoral, and intratumoral inflammatory infiltrate...
February 15, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29446675/colorectal-liver-metastasis-overview-of-treatment-paradigm-highlighting-the-role-of-ablation
#11
Shree R Venkat, Prasoon P Mohan, Ripal T Gandhi
OBJECTIVE: The objective of this article is to discuss the current treatment options for colorectal cancer (CRC) liver metastases and the role of ablation. CONCLUSION: A randomized control trial of ablation combined with chemotherapy showed improved overall survival compared with chemotherapy alone. Local recurrence rates are comparable to those associated with resection when ablative margins of more than 5 mm are achieved and target lesions are smaller than 3 cm...
February 15, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29445242/colorectal-cancer-associated-genes-are-associated-with-tooth-agenesis-and-may-have-a-role-in-tooth-development
#12
Meredith A Williams, Claudia Biguetti, Miguel Romero-Bustillos, Kanwal Maheshwari, Nuriye Dinckan, Franco Cavalla, Xiaoming Liu, Renato Silva, Sercan Akyalcin, Z Oya Uyguner, Alexandre R Vieira, Brad A Amendt, Walid D Fakhouri, Ariadne Letra
Previously reported co-occurrence of colorectal cancer (CRC) and tooth agenesis (TA) and the overlap in disease-associated gene variants suggest involvement of similar molecular pathways. Here, we took an unbiased approach and tested genome-wide significant CRC-associated variants for association with isolated TA. Thirty single nucleotide variants (SNVs) in CRC-predisposing genes/loci were genotyped in a discovery dataset composed of 440 individuals with and without isolated TA. Genome-wide significant associations were found between TA and ATF1 rs11169552 (P = 4...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29445027/a-curative-intent-trimodality-approach-for-isolated-abdominal-nodal-metastases-in-metastatic-colorectal-cancer-update-of-a-single-institutional-experience
#13
Benny Johnson, Zhaohui Jin, Michael G Haddock, Christopher L Hallemeier, James A Martenson, Rory L Smoot, David W Larson, Eric J Dozois, David M Nagorney, Axel Grothey
BACKGROUND: The purpose of this study was to define survival rates in patients with isolated advanced abdominal nodal metastases secondary to colorectal cancer (CRC), treated with curative-intent trimodality therapy. MATERIALS AND METHODS: Sixty-five patients received trimodality therapy, defined as chemotherapy delivered with external beam radiotherapy (EBRT) followed by lymphadenectomy and intraoperative radiotherapy (IORT). Infusional 5-fluorouracil was the most common radiosensitizer used (63%, 41 patients)...
February 14, 2018: Oncologist
https://www.readbyqxmd.com/read/29443647/system-level-health-care-integration-and-the-costs-of-cancer-care-across-the-disease-continuum
#14
Deborah R Kaye, Hye Sung Min, Edward C Norton, Zaojun Ye, Jonathan Li, James M Dupree, Chad Ellimoottil, David C Miller, Lindsey A Herrel
PURPOSE: Policy reforms in the Affordable Care Act encourage health care integration to improve quality and lower costs. We examined the association between system-level integration and longitudinal costs of cancer care. METHODS: We used linked SEER-Medicare data to identify patients age 66 to 99 years diagnosed with prostate, bladder, esophageal, pancreatic, lung, liver, kidney, colorectal, breast, or ovarian cancer from 2007 to 2012. We attributed each patient to one or more phases of care (ie, initial, continuing, and end of life) according to time from diagnosis until death or end of study interval...
February 13, 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29442465/polymorphism-of-gly39glu-c-116g-a-hmsh6-is-associated-with-sporadic-colorectal-cancer-development-in-the-polish-population-preliminary-results
#15
Piotr Zelga, Karolina Przybyłowska-Sygut, Marta Zelga, Adam Dziki, Ireneusz Majsterek
BACKGROUND: Colorectal cancer (CRC) remains a major source of cancer-related mortality, accounting for 10% of all cancer-related deaths. DNA mismatch repair mechanism (MMR) responsible for correcting errors generated during DNA replication and its deficiency is associated with both hereditary and sporadic CRC. Single-nucleotide polymorphisms (SNPs) are the most common forms of genetic variation, and it has been shown that the SNPs in MMR genes may modify CRC risk. OBJECTIVES: The aim of the study was to determine the relationship between gene polymorphism Glu39Gly (c...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29441725/high-expression-of-dj-1-promotes-growth-and-invasion-via-the-pten-akt-pathway-and-predicts-a-poor-prognosis-in-colorectal-cancer
#16
Yong Lin, Qian Chen, Quan-Xing Liu, Dong Zhou, Xiao Lu, Xu-Feng Deng, Hua Yang, Hong Zheng, Yuan Qiu
Cancer cell invasion and unlimited proliferation are key factors in patients with colorectal cancer (CRC). Increased protein deglycase DJ-1 in cancer cells is known to promote tumor growth; however, its role in CRC progression is not well defined. In this study, we investigated 100 CRC patients with disease stages I-IV to determine whether DJ-1 could serve as a prognostic biomarker in CRC. These results showed that DJ-1 expression in CRC tissues was higher than that in normal colon tissues and was associated with the (Tumor Node Metastasis) TNM stage...
February 14, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29441695/protein-phosphatase-2a-pp2a-inhibitor-cip2a-indicates-resistance-to-radiotherapy-in-rectal-cancer
#17
Eva-Maria Birkman, Adam Elzagheid, Terhi Jokilehto, Tuulia Avoranta, Eija Korkeila, Jarmo Kulmala, Kari Syrjänen, Jukka Westermarck, Jari Sundström
Preoperative (chemo)radiotherapy, (C)RT, is an essential part of the treatment of rectal cancer patients, but tumor response to this therapy among patients is variable. Thus far, there are no clinical biomarkers that could be used to predict response to (C)RT or to stratify patients into different preoperative treatment groups according to their prognosis. Overexpression of cancerous inhibitor of protein phosphatase 2A (CIP2A) has been demonstrated in several cancers and is frequently associated with reduced survival...
February 14, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29441349/liquid-biopsy-in-clinical-management-of-breast-lung-and-colorectal-cancer
#18
REVIEW
Ivana Bratić Hench, Jürgen Hench, Markus Tolnay
Examination of tumor molecular characteristics by liquid biopsy is likely to greatly influence personalized cancer patient management. Analysis of circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and tumor-derived exosomes, all collectively referred to as "liquid biopsies," are not only a modality to monitor treatment efficacy, disease progression, and emerging therapy resistance mechanisms, but they also assess tumor heterogeneity and evolution in real time. We review the literature concerning the examination of ctDNA and CTC in a diagnostic setting, evaluating their prognostic, predictive, and monitoring capabilities...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29440946/optimizing-the-use-of-anti-vegf-targeted-therapies-in-patients-with-metastatic-colorectal-cancer-review-of-literature
#19
REVIEW
Claudiu Hopirtean, Viorica Nagy
Colorectal cancer is one of the most frequent forms of cancer both in men and women, and patients with metastatic disease are now being exposed to an increasing number of therapeutic agents to improve the survival outcomes. Vascular endothelial growth factor (VEGF) has o key role in the tumor growth and spreading. The approval of 4 agents that target angiogenic pathways in combination with standard chemotherapy improve overall and progression free survival and offer many opportunities to sequencing the treatment in patients with metastatic colorectal cancer (mCRC)...
2018: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29440929/role-of-intestinal-flora-in-colorectal-cancer-from-the-metabolite-perspective-a-systematic-review
#20
REVIEW
Shuwen Han, Jianlan Gao, Qing Zhou, Shanshan Liu, Caixia Wen, Xi Yang
Colorectal cancer is one of the most common human malignant tumors. Recent research has shown that colorectal cancer is a dysbacteriosis-induced disease; however, the role of intestinal bacteria in colorectal cancer is unclear. This review explores the role of intestinal flora in colorectal cancer. In total, 57 articles were included after identification and screening. The pertinent literature on floral metabolites in colorectal cancer from three metabolic perspectives - including carbohydrate, lipid, and amino acid metabolism - was analyzed...
2018: Cancer Management and Research
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