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https://www.readbyqxmd.com/read/29679151/comparisons-of-the-surgical-outcomes-and-medical-costs-between-transferred-and-directly-admitted-patients-diagnosed-with-intestinal-obstruction-in-an-american-tertiary-referral-center
#1
Xian Hua Gao, Hanumant Chouhan, Emre Gorgun, Luca Stocchi, Gokhan Ozuner
PURPOSE: Intestinal obstruction is a leading cause of patient mortality and the most common reason for emergent operation in colorectal surgery. The influence of inter-hospital transfer on patients' outcomes varies greatly in different diseases. We aimed to compare the surgical outcomes and medical costs between transferred and directly admitted patients diagnosed with intestinal obstruction in an American tertiary referral center. METHODS: All intestinal obstruction patients operated in Cleveland Clinic from Jan 2012 to Dec 2016 were collected from a prospectively maintained database...
April 20, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29677931/predicting-clinical-outcomes-in-colorectal-cancer-using-machine-learning
#2
Julian Gründner, Hans-Ulrich Prokosch, Michael Stürzl, Roland Croner, Jan Christoph, Dennis Toddenroth
Using gene markers and other patient features to predict clinical outcomes plays a vital role in enhancing clinical decision making and improving prognostic accuracy. This work uses a large set of colorectal cancer patient data to train predictive models using machine learning methods such as random forest, general linear model, and neural network for clinically relevant outcomes including disease free survival, survival, radio-chemotherapy response (RCT-R) and relapse. The most successful predictive models were created for dichotomous outcomes like relapse and RCT-R with accuracies of 0...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29675984/associations-of-pre-existing-co-morbidities-with-skeletal-muscle-mass-and-radiodensity-in-patients-with-non-metastatic-colorectal-cancer
#3
Jingjie Xiao, Bette J Caan, Erin Weltzien, Elizabeth M Cespedes Feliciano, Candyce H Kroenke, Jeffrey A Meyerhardt, Vickie E Baracos, Marilyn L Kwan, Adrienne L Castillo, Carla M Prado
BACKGROUND AND AIM: Co-morbidities and computerized tomography-measured muscle abnormalities are both common in cancer patients and independently adversely influence clinical outcomes. Muscle abnormalities are also evident in other diseases, such as diabetes and obesity. This study examined for the first time the association between co-morbidities and muscle abnormalities in patients diagnosed with colorectal cancer (CRC). METHODS: This cross-sectional study included 3051 non-metastatic patients with Stages I-III CRC...
April 19, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29675807/the-prognostic-impact-of-cdx2-correlates-with-the-underlying-mismatch-repair-status-and-braf-mutational-status-but-not-with-distant-metastasis-in-colorectal-cancer
#4
Jens Neumann, Volker Heinemann, Jutta Engel, Thomas Kirchner, Sebastian Stintzing
Loss of CDX2 expression has been proposed to be a prognostic biomarker in colorectal cancer (CRC) correlating with shorter overall (OS) and progression-free survival (PFS). Since metastatic disease, mismatch repair (MMR) deficiency, and the mutational status of BRAF are considered to be important prognostic determinants in CRC, the present study aimed to analyze CDX2 expression in correlation with these parameters. Immunohistochemistry for CDX2, hMLH1, and hMSH2 was applied to a study cohort of 503 CRC specimens (FIRE-3) and a matched case-control collection of 50 right-sided CRC specimens with synchronous distant metastases and 50 right-sided CRCs without distant metastases...
April 19, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29675590/oncological-outcomes-of-ibd-associated-versus-sporadic-colorectal-cancer-in-modern-era-a-matched-case-control-study
#5
Antoine Thicoïpé, David Laharie, Denis Smith, Edouard Chabrun, Anne Rullier, Florian Poullenot, Eric Rullier, Quentin Denost
AIM: Inflammatory bowel diseases (IBD) are associated with an increased risk for colorectal cancer (CRC). However and despite significant advances in the management of IBD and CRC, the prognosis of IBD-related CRC (IBD-CRC) remains controversial. The aim of the present case-control study was to compare the prognosis of IBD-CRC to sporadic CRC. METHODS: Consecutive patients operated for IBD-CRC from 2004 to 2014 were recruited and matched with sporadic CRC (ratio 3:1) from the same center...
April 19, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29674439/outcome-of-mismatch-repair-deficient-metastatic-colorectal-cancer-the-mayo-clinic-experience
#6
Zhaohui Jin, Cristobal T Sanhueza, Benny Johnson, David M Nagorney, David W Larson, Kristin C Mara, William C Harmsen, Thomas C Smyrk, Axel Grothey, Joleen M Hubbard
BACKGROUND: Deficiencies in the DNA mismatch repair system cause errors during DNA replication, which in turn give rise to microsatellite instability (MSI). The impact of MSI on survival in metastatic colorectal cancer (mCRC) is unclear. This cohort study aims to investigate the prognostic and predictive value of MSI in mCRC prior to the immune therapy era. MATERIALS AND METHODS: A total of 75 MSI-high (MSI-H) mCRC patients (pts) and 75 matched (age, gender, disease sidedness, metachronous/synchronous) microsatellite-stable (MSS) mCRC pts were identified from 1,268 mCRC pts who had MSI/mismatch repair test results at Mayo Clinic Rochester between January 1992 and July 2016...
April 19, 2018: Oncologist
https://www.readbyqxmd.com/read/29672572/colorectal-cancer-and-cryptosporidium-spp-infection
#7
Violetta Sulżyc-Bielicka, Lidia Kołodziejczyk, Sylwia Jaczewska, Dariusz Bielicki, Krzysztof Safranow, Paweł Bielicki, Józef Kładny, Wojciech Rogowski
Transient or constant impaired immunity is often associated with neoplastic disease or oncological treatment. Among the most common pathogens found in patients with HIV or patients undergoing chemotherapy are protozoans of the Cryptosporidium genus, which cause diarrhea in humans and animals. The present study determined the frequency of Cryptosporidium spp. infections in patients with colorectal cancer (N = 108; 42 women; 66 men; median age, 65 years), before beginning oncological treatment, compared to a control group (N = 125; 56 women, 69 men; median age, 63 years) without colorectal cancer or a history of oncological disease...
2018: PloS One
https://www.readbyqxmd.com/read/29672549/tumor-development-in-japanese-patients-with-lynch-syndrome
#8
Chiaki Saita, Tatsuro Yamaguchi, Shin-Ichiro Horiguchi, Rin Yamada, Misato Takao, Takeru Iijima, Rika Wakaume, Tomoyuki Aruga, Taku Tabata, Koichi Koizumi
BACKGROUND: Lynch syndrome (LS) patients have a high risk of developing various tumors. This study aimed to clarify the characteristics of tumors developing in LS patients. METHODS: This is a retrospective review of 55 LS patients treated at Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital. RESULTS: The median age at the diagnosis of the first malignant tumor and first LS-related tumor was 44 (range, 19-65) and 44 (range, 24-66) years, respectively...
2018: PloS One
https://www.readbyqxmd.com/read/29672532/the-effects-of-increasing-longevity-and-changing-incidence-on-lifetime-risk-differentials-a-decomposition-approach
#9
Marcus Ebeling, Karin Modig, Anders Ahlbom, Roland Rau
Increasing longevity can distort time trends in summary measures of health and mortality, such as the lifetime risk of getting diseased. If not observing a cohort, this lifetime risk is calculated with cross-sectional data on age-specific incidence and survival. In those instances, incidence and survival may work in opposite directions resulting in lifetime risk estimates where, reductions in incidence might be offset by a simultaneous longevity increase. The proposed method decomposes the difference between two lifetime risks into contributions of changing incidence and changing survival...
2018: PloS One
https://www.readbyqxmd.com/read/29671505/care-of-the-colorectal-cancer-survivor
#10
Kristina Burgers, Clint Moore, Lori Bednash
Colorectal cancer is the fourth most common cancer in the United States and has a five-year survival rate of 65%. The American Cancer Society and other experts have released guidelines on surveillance, health promotion, screening for other malignancies, and management of treatment effects. Surveillance for disease recurrence should occur every three to six months for the first two to three years, then every six months for a total of five years. Each visit should include a history and physical examination, routine care for chronic medical conditions, and screening for other primary cancers according to guidelines for the general population...
March 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29671139/treatment-of-isolated-peritoneal-recurrences-in-patients-with-colorectal-peritoneal-metastases-previously-treated-with-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#11
Wijntje J van Eden, Fortuné M K Elekonawo, Bas J Starremans, Niels F M Kok, André J A Bremers, Johannes H W de Wilt, Arend G J Aalbers
BACKGROUND: Colorectal peritoneal carcinomatosis (PC) is preferably treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Peritoneal recurrence of disease after treatment can occur without distant metastases, with a variety of treatment options. OBJECTIVE: This study aimed to evaluate the management of isolated peritoneal recurrence after primary CRS-HIPEC. METHODS: In two tertiary referral centers, all patients who underwent CRS-HIPEC for colorectal PC between 2004 and 2015 and who developed isolated peritoneal recurrences were retrospectively evaluated...
April 18, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29670399/poorer-prognosis-in-young-female-patients-with-non-metastatic-colorectal-cancer-a-hospital-based-analysis-of-5-047-patients-in-china
#12
Lijun Shen, Miao Mo, Leon Jia, Huixun Jia, Qingguo Li, Lei Liang, Debing Shi, Zhen Zhang, Sanjun Cai, Xinxiang Li, Ji Zhu
Purpose: To investigate the association of age and sex on survival in non-metastatic colorectal cancer (CRC) patients and to identify groups at high risk for poor outcomes. Materials and methods: We performed a retrospective analysis of 5,047 non-metastatic CRC patients from 2008 to 2013. Data regarding age at diagnosis; gender; tumor site; tumor stage; differentiation; lymphatic, neural or vascular invasion; and survival outcomes were collected. Patients were stratified into 10-year age groups (≤35, 36-45, 46-55, 56-65, 66-75, >75) and then further analyzed in three age groups (≤35, 36-75, >75)...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29669932/nardilysin-controls-intestinal-tumorigenesis-through-hdac1-p53-dependent-transcriptional-regulation
#13
Keitaro Kanda, Jiro Sakamoto, Yoshihide Matsumoto, Kozo Ikuta, Norihiro Goto, Yusuke Morita, Mikiko Ohno, Kiyoto Nishi, Koji Eto, Yuto Kimura, Yuki Nakanishi, Kanako Ikegami, Takaaki Yoshikawa, Akihisa Fukuda, Kenji Kawada, Yoshiharu Sakai, Akihiro Ito, Minoru Yoshida, Takeshi Kimura, Tsutomu Chiba, Eiichiro Nishi, Hiroshi Seno
Colon cancer is a complex disease affected by a combination of genetic and epigenetic factors. Here we demonstrate that nardilysin (N-arginine dibasic convertase; NRDC), a metalloendopeptidase of the M16 family, regulates intestinal tumorigenesis via its nuclear functions. NRDC is highly expressed in human colorectal cancers. Deletion of the Nrdc gene in ApcMin mice crucially suppressed intestinal tumor development. In ApcMin mice, epithelial cell-specific deletion of Nrdc recapitulated the tumor suppression observed in Nrdc-null mice...
April 19, 2018: JCI Insight
https://www.readbyqxmd.com/read/29669684/impact-on-surgical-and-oncological-results-of-the-use-of-colonic-stents-as-a-bridge-to-surgery-for-potentially-curable-occlusive-colorectal-neoplasms
#14
Antònia Crespí-Mir, Juan Manuel Romero-Marcos, Anabel de la Llave-Serralvo, Carlos Dolz-Abadía, José Andrés Cifuentes-Ródenas
INTRODUCTION: The outcomes of patients treated with colonic stents as a bridge to surgery (BTS) have recently been questioned in terms of safety and long-term oncologic outcomes. The aim of this study is to evaluate the effects on surgical and oncologic outcomes of colonic stents as a BTS for potentially resectable obstructive colorectal cancer. METHODS: We conducted a retrospective analysis of patients operated on for potentially resectable obstructive colorectal cancer with or without distant disease between September 2002 and October 2015, comparing the patients treated with a colonic stent as a BTS (Stent group) with those directly operated on (Surgery group)...
April 15, 2018: Cirugía Española
https://www.readbyqxmd.com/read/29669343/major-hepatectomy-for-colorectal-liver-metastases-in-patients-aged-over-80-a-propensity-score-matching-analysis
#15
Vito De Blasi, Riccardo Memeo, René Adam, Diane Goéré, Daniel Cherqui, Jean Marc Regimbeau, Michel Rivoire, Laura Ornella Perotto, Francis Navarro, Antonio Sa Cunha, Patrick Pessaux
BACKGROUND: The aim of this study was to evaluate the results of major hepatectomies for metastasis in elderly colorectal cancer patients, for whom limited data exist in the literature. METHODS: From January 2006 to January 2013, 3,034 patients underwent hepatectomy for colorectal liver metastasis in 32 French surgical centers. Repeat hepatectomies were excluded from the study. Based on a 1: 4 propensity score matching model, 42 patients aged ≥80 (OG) were matched with 168 patients <80 years (YG) in order to obtain 2 well-balanced and homogeneous groups with regards to therapy and prognostic factors...
April 17, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29668968/outcomes-of-endoscopic-resections-of-large-laterally-spreading-colorectal-lesions-in-inflammatory-bowel-disease-a-single-united-kingdom-center-experience
#16
Shraddha Gulati, Andrew Emmanuel, Margaret Burt, Patrick Dubois, Bu'Hussain Hayee, Amyn Haji
Background: The SCENIC consensus statement recommends endoscopic resection of all visible dysplasia in inflammatory bowel disease, but patients with large or complex lesions may still be advised to have colectomy. This article presents outcomes for large nonpolypoid resections associated with colitis at our institution. Methods: Data including demographics, clinical history, lesion characteristics, method of resection, and postresection surveillance were collected prospectively in patients with visible lesions within colitic mucosa from January 2011 to November 2016...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29668929/chromoendoscopy-for-dysplasia-surveillance-in-inflammatory-bowel-disease
#17
Ann D Flynn, John F Valentine
Long-standing ulcerative colitis (UC) and extensive Crohn's colitis confer increased risk for development of colorectal cancer. Screening and surveillance colonoscopy programs aim to identify, resect, or detect dysplasia or colorectal cancer. Dysplastic lesions can be removed by endoscopic resection and patients with unresectable lesions can be referred for colectomy at an earlier stage, with the goal of reducing overall morbidity and mortality from colorectal cancer. Surveillance colonoscopy for patients with inflammatory bowel disease (IBD) is endorsed by multiple specialty societies...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29668897/dysplasia-in-inflammatory-bowel-disease-historical-review-critical-histopathological-analysis-and-clinical-implications
#18
Anders Mark-Christensen, Søren Laurberg, Najib Haboubi
Colorectal cancer is the most serious complication of chronic inflammatory bowel disease. It is generally accepted that dysplasia in most cases precedes the development of colorectal cancer. Thus, detection of dysplasia through surveillance may allow therapeutic interventions to lower the risk of cancer. Our understanding of dysplasia has evolved over the past decades and guided rational decision-making, but many questions remain unanswered. We are currently at the brink of a new era, where new avenues in the endoscopic detection and management of dysplasia are pursued, and the paradigm of a colectomy being the preferred treatment for advanced neoplasia is changing...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29667123/peritoneal-carcinomatosis-arising-from-rectal-or-colonic-adenocarcinoma-treated-with-cytoreductive-surgery-crs-hyperthermic-intraperitoneal-chemotherapy-hipec-two-different-diseases
#19
M Tonello, G Ortega-Perez, O Alonso-Casado, P Torres-Mesa, G Guiñez, S Gonzalez-Moreno
PURPOSE: Peritoneal carcinomatosis (PC) from colorectal cancer (CRC) has poor survival. Multi-modal treatment including systemic chemotherapy, cytoreductive surgery (CRS), and hyperthermic intraperitoneal chemotherapy (HIPEC) can be used in selected patients with curative intent. The majority published works consider PC of CRC origin as a homogenous disease. Aim of this study is to stress the different biological behaviors and survival of PC according to colonic or rectal origin. METHODS: Data of CRS and HIPEC procedures for PC of CRC origin performed at MD Anderson Cancer Center-Madrid (Spain) have been collected, dividing patients into two groups according to colonic or rectal PC...
April 17, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29666906/radiofrequency-and-microwave-ablation-compared-to-systemic-chemotherapy-and-to-partial-hepatectomy-in-the-treatment-of-colorectal-liver-metastases-a-systematic-review-and-meta-analysis
#20
Martijn R Meijerink, Robbert S Puijk, Aukje A J M van Tilborg, Kirsten Holdt Henningsen, Llenalia Garcia Fernandez, Mattias Neyt, Juanita Heymans, Jacqueline S Frankema, Koert P de Jong, Dick J Richel, Warner Prevoo, Joan Vlayen
PURPOSE: To assess safety and outcome of radiofrequency ablation (RFA) and microwave ablation (MWA) as compared to systemic chemotherapy and partial hepatectomy (PH) in the treatment of colorectal liver metastases (CRLM). METHODS: MEDLINE, Embase and the Cochrane Library were searched. Randomized trials and comparative observational studies with multivariate analysis and/or matching were included. Guidelines from National Guideline Clearinghouse and Guidelines International Network were assessed using the AGREE II instrument...
April 17, 2018: Cardiovascular and Interventional Radiology
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