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Interleukin 17 receptor lung cancer

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https://www.readbyqxmd.com/read/27375020/interleukin-17-promotes-prostate-cancer-via-mmp7-induced-epithelial-to-mesenchymal-transition
#1
Q Zhang, S Liu, K R Parajuli, W Zhang, K Zhang, Z Mo, J Liu, Z Chen, S Yang, A R Wang, L Myers, Z You
Chronic inflammation has been associated with a variety of human cancers including prostate cancer. Interleukin-17 (IL-17) is a critical pro-inflammatory cytokine, which has been demonstrated to promote development of prostate cancer, colon cancer, skin cancer, breast cancer, lung cancer and pancreas cancer. IL-17 promotes prostate adenocarcinoma with a concurrent increase of matrix metalloproteinase 7 (MMP7) expression in mouse prostate. Whether MMP7 mediates IL-17's action and the underlying mechanisms remain unknown...
July 4, 2016: Oncogene
https://www.readbyqxmd.com/read/26168835/immune-regulation-of-interleukin-27-in-malignant-pleural-effusion
#2
Shi Li, Wen-Jie You, Jian-Chu Zhang, Qiong Zhou, Huan-Zhong Shi
BACKGROUND: Interleukin (IL)-27 has been reported to have anti-proliferate and anti-angiogenic activities on cancer cells. However, the involvement of IL-27 in malignant pleural effusion (MPE) remains unknown. Thus, in this research, we compared the immune functions of IL-27, interferon (IFN)-γ, and IL-17 on lung cancer cells and revealed the regulatory mechanism of IL-27 in MPE. METHODS: The distribution of IL-27 in both MPE and blood was evaluated by enzyme-linked immunosorbent assay and flow cytometry...
July 20, 2015: Chinese Medical Journal
https://www.readbyqxmd.com/read/26138771/angiogenesis-biomarkers-may-be-useful-in-the-management-of-patients-with-indeterminate-pulmonary-nodules
#3
Christopher W Seder, John C Kubasiak, Ravi Pithadia, Sanjib Basu, Cristina Fhied, Imad Tarhoni, Edgar Davila, Hanan Alnajjar, Gary W Chmielewski, William H Warren, Michael J Liptay, Jeffrey A Borgia
BACKGROUND: Low-dose computed tomography (CT) lung cancer screening is known to have a high false positive rate. This study aims to survey biomarkers of angiogenesis for those capable of assigning clinical significance to indeterminate pulmonary nodules detected through CT imaging studies. METHODS: An institutional database and specimen repository was used to identify 193 patients with stage I non-small cell lung cancer (T1N0M0) and 110 patients with benign solitary pulmonary nodules detected by CT imaging studies...
August 2015: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/25750307/predominance-of-th17-over-regulatory-t-cells-in-pleural-effusions-of-patients-with-lung-cancer-implicates-a-proinflammatory-profile
#4
Heriberto Prado-Garcia, Susana Romero-Garcia, Uriel Rumbo-Nava, Jose Sullivan Lopez-Gonzalez
BACKGROUND: Regulatory T-(Treg) and pro-inflammatory T-helper 17 (Th17) cells have been reported to be involved in the pathogenesis of pleural effusions caused by lung cancer. However, the presence of these subsets might not be a consequence of tumor pathogenesis, but rather a result of the pleural effusion itself, irrespective of its origin. In the present study, we analyzed the balance between these CD4+ T-cell subsets and compared them with those in non-malignant pleural effusions...
March 2015: Anticancer Research
https://www.readbyqxmd.com/read/25524262/additive-antitumour-response-to-the-rabbit-vx2-hepatoma-by-combined-radio-frequency-ablation-and-toll-like-receptor-9-stimulation
#5
Barbara Behm, Pietro Di Fazio, Patrick Michl, Daniel Neureiter, Ralf Kemmerling, Eckhart Georg Hahn, Deike Strobel, Thomas Gress, Detlef Schuppan, Thaddaeus Till Wissniowski
INTRODUCTION: Radiofrequency ablation (RFA), a palliative therapeutic option for solid hepatic tumours, stimulates localised and systemic antitumour cytotoxic T cells. We studied how far addition of CpG B oligonucleotides, toll like receptor (TLR) 9 agonists, would increase the antitumoural T cell response of RFA in the highly aggressive VX2 hepatoma. METHODS: Rabbits were randomised to receive RFA, CpG B, their combination or no therapy. The antitumour efficacy of RFA alone or in combination with CpG B was further tested by rechallenging a separate group with intravenously injected VX2 tumour cells after 120 days...
January 2016: Gut
https://www.readbyqxmd.com/read/25371165/treg-th17-imbalance-in-malignant-pleural-effusion-partially-predicts-poor-prognosis
#6
Guangdie Yang, Hequan Li, Yinan Yao, Fei Xu, Zhang Bao, Jianying Zhou
Accumulating evidence shows that an imbalance in regulatory T cells (Tregs)/T helper IL-17-producing cells (Th17) exists in malignant pleural effusion (MPE). However, the cause of this phenomenon in MPE and the underlying mechanism remain uncertain. The percentages of Tregs and Th17 cells in MPE and parapneumonic effusion (PPE) were determined by flow cytometry. Their specific transcription factors, forkhead box P3 (FoxP3) and retinoic acid-related orphan receptor γt (RORγt); related cytokines, interleukin-6 (IL-6), IL-17, IL-10, and transforming growth factor-β1 (TGF‑β1); and chemokines, C-C motif ligand 17 (CCL17) and CCL20, were analyzed by real-time PCR and ELISA, respectively...
January 2015: Oncology Reports
https://www.readbyqxmd.com/read/25250715/association-between-gene-expression-profiles-and-clinical-outcome-of-pemetrexed-based-treatment-in-patients-with-advanced-non-squamous-non-small-cell-lung-cancer-exploratory-results-from-a-phase-ii-study
#7
Dean A Fennell, Scott P Myrand, Tuan S Nguyen, David Ferry, Keith M Kerr, Perry Maxwell, Stephen D Moore, Carla Visseren-Grul, Mayukh Das, Marianne C Nicolson
INTRODUCTION: We report exploratory gene-expression profiling data from a single-arm Phase-II-study in patients with non-squamous (ns)NSCLC treated with pemetrexed and cisplatin. Previously disclosed results indicated a significant association of low thymidylate-synthase (TS)-expression with longer progression-free and overall survival (PFS/OS). METHODS: Treatment-naïve nsNSCLC patients (IIIB/IV) received 4 cycles of pemetrexed/cisplatin; non-progressing patients continued on pemetrexed-maintenance...
2014: PloS One
https://www.readbyqxmd.com/read/23913124/an-interleukin-17-mediated-paracrine-network-promotes-tumor-resistance-to-anti-angiogenic-therapy
#8
Alicia S Chung, Xiumin Wu, Guanglei Zhuang, Hai Ngu, Ian Kasman, Jianhuan Zhang, Jean-Michel Vernes, Zhaoshi Jiang, Y Gloria Meng, Franklin V Peale, Wenjun Ouyang, Napoleone Ferrara
Although angiogenesis inhibitors have provided substantial clinical benefit as cancer therapeutics, their use is limited by resistance to their therapeutic effects. While ample evidence indicates that such resistance can be influenced by the tumor microenvironment, the underlying mechanisms remain incompletely understood. Here, we have uncovered a paracrine signaling network between the adaptive and innate immune systems that is associated with resistance in multiple tumor models: lymphoma, lung and colon. Tumor-infiltrating T helper type 17 (T(H)17) cells and interleukin-17 (IL-17) induced the expression of granulocyte colony-stimulating factor (G-CSF) through nuclear factor κB (NF-κB) and extracellular-related kinase (ERK) signaling, leading to immature myeloid-cell mobilization and recruitment into the tumor microenvironment...
September 2013: Nature Medicine
https://www.readbyqxmd.com/read/23481504/cd11c-alveolar-macrophages-are-a-source-of-il-23-during-lipopolysaccharide-induced-acute-lung-injury
#9
Markus Bosmann, Jamison J Grailer, Norman F Russkamp, Robert Ruemmler, Firas S Zetoune, J Vidya Sarma, Peter A Ward
Acute lung injury (ALI) is a severe pulmonary disease causing high numbers of fatalities worldwide. Innate immune responses are an integral part of the pathophysiologic events during ALI. Interleukin 23 (IL-23) is a proinflammatory mediator known to direct the inflammatory responses in various settings of infection, autoimmunity, and cancer. Interleukin 23 has been associated with proliferation and effector functions in T(H)17 cells. Surprisingly, little is known about production of IL-23 during ALI. In this study, we found expression of mRNA for IL-23p19 to be 10-fold elevated in lung homogenates of C57BL/6 mice after lipopolysaccharide (LPS)-induced ALI...
May 2013: Shock
https://www.readbyqxmd.com/read/23308054/irf-8-controls-melanoma-progression-by-regulating-the-cross-talk-between-cancer-and-immune-cells-within-the-tumor-microenvironment
#10
Fabrizio Mattei, Giovanna Schiavoni, Paola Sestili, Francesca Spadaro, Alessandra Fragale, Antonella Sistigu, Valeria Lucarini, Massimo Spada, Massimo Sanchez, Stefania Scala, Angela Battistini, Filippo Belardelli, Lucia Gabriele
The transcription factor interferon regulatory factor-8 (IRF-8) is crucial for myeloid cell development and immune response and also acts as a tumor suppressor gene. Here, we analyzed the role of IRF-8 in the cross talk between melanoma cells and tumor-infiltrating leukocytes. B16-F10 melanoma cells transplanted into IRF-8-deficient (IRF-8(-/-)) mice grow more rapidly, leading to higher numbers of lung metastasis, with respect to control animals. These events correlated with reduced dendritic cell and T cell infiltration, accumulation of myeloid-derived suppressor cells and a chemokine/chemokine receptor expression profile within the tumor microenvironment supporting tumor growth, angiogenesis, and metastasis...
December 2012: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/23201823/development-and-validation-of-a-plasma-biomarker-panel-for-discerning-clinical-significance-of-indeterminate-pulmonary-nodules
#11
Shaun Daly, Daniel Rinewalt, Cristina Fhied, Sanjib Basu, Brett Mahon, Michael J Liptay, Edward Hong, Gary Chmielewski, Mark A Yoder, Palmi N Shah, Eric S Edell, Fabien Maldonado, Aaron O Bungum, Jeffrey A Borgia
INTRODUCTION: The recent findings of the National Lung Screening Trial showed 24.2% of individuals at high risk for lung cancer having one or more indeterminate nodules detected by low-dose computed tomography-based screening, 96.4% of which were eventually confirmed as false positives. These positive scans necessitate additional diagnostic procedures to establish a definitive diagnosis that adds cost and risk to the paradigm. A plasma test able to assign benign versus malignant pathology in high-risk patients would be an invaluable tool to complement low-dose computed tomography-based screening and promote its rapid implementation...
January 2013: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/23089548/il-17-promoted-metastasis-of-non-small-cell-lung-cancer-cells
#12
Qinchuan Li, Yang Han, Guangru Fei, Zhongliang Guo, Tao Ren, Zhongmin Liu
Non-small cell lung cancer (NSCLC) is the leading cause of cancer death worldwide. Recent data suggested that IL-17 might be a pivotal cytokine involved in tumor progression of NSCLC. However, the direct effect of IL-17 on metastasis of NSCLC cells still remains intractable. In this study, we found that the metastasis of NSCLC was significantly impaired in IL-17⁻/⁻ mice. Further, we revealed that IL-17 could directly promote the invasion of NSCLC cells both in vitro and in vivo. Furthermore, we found that IL-6-Stat3 pathway was crucial for IL-17 to enhance the invasive potential of NSCLC cells...
December 17, 2012: Immunology Letters
https://www.readbyqxmd.com/read/23042301/functional-genetic-variations-in-the-il-23-receptor-gene-are-associated-with-risk-of-breast-lung-and-nasopharyngeal-cancer-in-chinese-populations
#13
Jian Zheng, Lan Jiang, Liyuan Zhang, Lei Yang, Jieqiong Deng, Yonghe You, Na Li, Hongchun Wu, Wei Li, Jiachun Lu, Yifeng Zhou
Interleukin-23 receptor (IL-23R) is a key element in the T-helper 17 cell-mediated inflammatory process, which plays an important role in the pathogenesis of cancer. In this study, we examined whether genetic polymorphisms in IL-23R are associated with cancer risk in 4936 cancer patients and 5664 control subjects from eastern and southern Chinese populations. We found that the C allele of the rs10889677A>C polymorphism in the 3'-untranslated region of IL-23R was inversely associated with risk of multiple types of cancer, including breast cancer, lung cancer and nasopharyngeal carcinoma...
December 2012: Carcinogenesis
https://www.readbyqxmd.com/read/22772464/robust-tumor-immunity-to-melanoma-mediated-by-interleukin-9-producing-t-cells
#14
Rahul Purwar, Christoph Schlapbach, Sheng Xiao, Hong Soon Kang, Wassim Elyaman, Xiaodong Jiang, Anton M Jetten, Samia J Khoury, Robert C Fuhlbrigge, Vijay K Kuchroo, Rachael A Clark, Thomas S Kupper
Interleukin-9 (IL-9) is a T cell cytokine that acts through a γC-family receptor on target cells and is associated with inflammation and allergy. We determined that T cells from mice deficient in the T helper type 17 (T(H)17) pathway genes encoding retinoid-related orphan receptor γ (ROR-γ) and IL-23 receptor (IL-23R) produced abundant IL-9, and we found substantial growth inhibition of B16F10 melanoma in these mice. IL-9-blocking antibodies reversed this tumor growth inhibition and enhanced tumor growth in wild-type (WT) mice...
August 2012: Nature Medicine
https://www.readbyqxmd.com/read/22534817/interleukin-17-and-prostaglandin-e2-are-involved-in-formation-of-an-m2-macrophage-dominant-microenvironment-in-lung-cancer
#15
COMPARATIVE STUDY
Lunxu Liu, Dongxia Ge, Lin Ma, Jiandong Mei, Sen Liu, Qiuyang Zhang, Fuqiang Ren, Hu Liao, Qiang Pu, Tao Wang, Zongbing You
INTRODUCTION: Tumor-associated macrophages (TAMs) are divided into M1 and M2 macrophages. M1 macrophages inhibit tumor growth, whereas M2 macrophages promote tumor growth and metastasis. The aim of this study was to examine the possible causes leading to the formation of an M2-macrophage-dominant tumor microenvironment in non-small-cell lung cancer. METHODS: Forty-eight archived lung tumor samples were examined for the expression of interleukin-17 (IL-17) receptors, IL-17 receptor A (IL-17RA) and IL-17 receptor C (IL-17RC), and the number of TAMs using immunohistochemical staining...
July 2012: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/22158905/immunotherapy-with-pi3k-inhibitor-and-toll-like-receptor-agonist-induces-ifn-%C3%AE-il-17-polyfunctional-t-cells-that-mediate-rejection-of-murine-tumors
#16
Neil A Marshall, Karen C Galvin, Anna-Maria B Corcoran, Louis Boon, Rowan Higgs, Kingston H G Mills
The immunosuppressive microenvironment in tumors hampers the induction of antitumor immunity by vaccines or immunotherapies. Toll-like receptor (TLR) ligands have the potential to treat tumors, but they can exert a mixture of positive and negative effects on inflammation in the tumor microenvironment. In this study, we show that specific small molecule inhibitors of phosphoinositide 3-kinase (PI3K) relieve immunosuppression to heighten the proinflammatory effects of TLR ligands that support antitumor immunity...
February 1, 2012: Cancer Research
https://www.readbyqxmd.com/read/21949768/involvement-of-ccr6-ccl20-il-17-axis-in-nsclc-disease-progression
#17
Sophie Kirshberg, Uzi Izhar, Gail Amir, Jonathan Demma, Fiona Vernea, Katia Beider, Zippora Shlomai, Hanna Wald, Gideon Zamir, Oz M Shapira, Amnon Peled, Ori Wald
OBJECTIVES: Autocrine and paracrine chemokine/chemokine receptor-based interactions promote non-small-cell-lung-cancer (NSCLC) carcinogenesis. CCL20/CCR6 interactions are involved in prostatic and colonic malignancy pathogenesis. The expression and function of CCL20/CCR6 and its related Th-17 type immune response in NSCLC is not yet defined. We sought to characterize the role of the CCL20/CCR6/IL-17 axis in NSCLC tumor growth. METHODS: A specialized histopathologist blindly assessed CCL20/CCR6 expression levels in 49 tissue samples of NSCLC patients operated in our department...
2011: PloS One
https://www.readbyqxmd.com/read/21785272/effects-of-il-17a-on-the-occurrence-of-lung-adenocarcinoma
#18
Ying Li, Zhen Yuan Cao, Bo Sun, Guang You Wang, Zheng Fu, Yu Mei Liu, Qing Fei Kong, Jing Hua Wang, Yao Zhang, Xiang Ying Xu, Hu Lun Li
The relationship between IL-17A and cancer, whether beneficial or antagonistic, continues to be a controversial issue. In this study, effects of IL-17A on lung adenocarcinoma were investigated using lung cancer cell lines, 95D and 95C. In the presence or absence of IL-17A, cell proliferation and VEGF secretion were detected. Effects of IL-17A on capillary networks and process of angiogenesis were also evaluated. In vivo, the level of IL-17A was assayed in the serum of lung adenocarcinoma patients. At the same time, slices of adenocarcinoma tissue were analyzed for expression of IL-17A, its receptor (IL-17RA), VEGF, CD4(+)-IL-17A+ cells and CD8(+)-IL-17A+ cells by immunohistochemistry and immunofluorescence assays...
October 1, 2011: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/21348427/toll-like-receptor-2-mediates-bleomycin-induced-acute-lung-injury-inflammation-and-fibrosis-in-mice
#19
Han-zhi Liu, Hong-zhen Yang, Su Mi, Bing Cui, Fang Hua, Zhuo-wei Hu
Anti-cancer drug bleomycin (BLM) can cause acute lung injury (ALI) which often results in pulmonary fibrosis due to a failure of resolving acute inflammatory response. The aim of this study is to investigate whether toll-like receptor (TLR) 2 mediates BLM-induced ALI, inflammation and fibrosis. BLM-induced dendritic cells (DCs) maturation was analyzed by flow cytometry and cytokine secretion was detected by the ELISA method. The expression and activity of p38 and ERK MAPK were determined with Western blotting...
August 2010: Yao Xue Xue Bao, Acta Pharmaceutica Sinica
https://www.readbyqxmd.com/read/20825419/role-of-interleukin-17-in-lymphangiogenesis-in-non-small-cell-lung-cancer-enhanced-production-of-vascular-endothelial-growth-factor-c-in-non-small-cell-lung-carcinoma-cells
#20
Xi Chen, Qichao Xie, Xiaoming Cheng, Xinwei Diao, Yue Cheng, Jiankun Liu, Wei Xie, Zhengtang Chen, Bo Zhu
Interleukin-17 (IL-17), a potent pro-inflammatory cytokine, plays an active role in inflammation and cancer. Recently, we found that increased IL-17-producing cells correlate with poor survival and increased lymphangiogenesis in non-small-cell lung cancer (NSCLC), but the mechanism is unknown. Here, we show that IL-17 promotes lymphangiogenesis via inducing vascular endothelial growth factor-C (VEGF-C) production by lung cancer cells. We found that IL-17 receptor (IL-17R) is expressed on the surface of Lewis lung carcinoma (LLC) cells but not on lymphatic endothelial cells (LEC)...
November 2010: Cancer Science
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