Nozomi Takahashi, Ineke Vanlaere, Riet de Rycke, Anje Cauwels, Leo A B Joosten, Erik Lubberts, Wim B van den Berg, Claude Libert
Tumor necrosis factor (TNF) has very potent antitumor activity, but it also provokes a systemic inflammatory response syndrome that leads to shock, organ failure, and death. Here, we demonstrate that interleukin (IL)-17, a proinflammatory cytokine known to be produced mainly by activated T cells, has a critical role in this process. Antiserum against IL-17 or deletion of Il17r protected mice against a lethal TNF challenge. Serum levels of TNF-induced IL-6 and nitric oxide metabolites were significantly reduced in mice deficient in the IL-17R...
August 4, 2008: Journal of Experimental Medicine