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Interleukin 17 receptor IL17r

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https://www.readbyqxmd.com/read/25484349/association-between-interleukin-17-interleukin-17-receptor-gene-polymorphisms-and-papillary-thyroid-cancer-in-korean-population
#1
Young Chan Lee, Joo-Ho Chung, Su Kang Kim, Sang Youl Rhee, Suk Chon, Seung Joon Oh, Il Ki Hong, Young Gyu Eun
BACKGROUND: Although numerous recent studies have implicated a role for interleukin 17(IL17) in tumor development, the mechanisms of IL17 involvement are still uncharacterized. The aims of this study were to determine whether single nucleotide polymorphisms (SNPs) in IL17 and IL17R contribute to the development of papillary thyroid cancer (PTC) and to assess the relationship between IL17 and IL17R SNPs and the clinicopathologic characteristics of PTC. MATERIALS AND METHODS: Eight SNPs located within the IL17A, IL17RA, and IL17RB genes were genotyped using direct sequencing in 94 patients with PTC and 260 patients without PTC (controls)...
February 2015: Cytokine
https://www.readbyqxmd.com/read/24677511/the-selective-anti-il17a-monoclonal-antibody-secukinumab-ain457-attenuates-il17a-induced-levels-of-il6-in-human-astrocytes
#2
Gaelle Elain, Karine Jeanneau, Aleksandra Rutkowska, Anis K Mir, Kumlesh K Dev
The family of interleukin 17 receptors (IL17Rs), subtypes IL17RA-IL17RE, is targeted by the group of pro-inflammatory IL17 cytokines (IL17A-F) and moreover the newly developed anti-IL17A antibody secukinumab (AIN457) has shown promise in Phase II trials in multiple sclerosis. Here, we show that human astrocytes, isolated from a fetal cerebral cortex, express IL17RA and IL17RC and in vitro treatment with IL17A increases protein levels of IL6 in human astrocytes, which is enhanced in the presence of TNFα, as determined by homogeneous time resolved fluorescence...
May 2014: Glia
https://www.readbyqxmd.com/read/24602926/characterization-and-mucosal-responses-of-interleukin-17-family-ligand-and-receptor-genes-in-channel-catfish-ictalurus-punctatus
#3
Xingqiang Wang, Chao Li, Wilawan Thongda, Yupeng Luo, Benjamin Beck, Eric Peatman
Interleukin (IL) 17 family cytokines are important mediators of mucosal immune responses, tightly regulated by signals from the complex milieu of pathogenic and commensal microbes, epithelial cells and innate and adaptive leukocytes found at tissue barriers. In mammals, IL17 ligand expression has been linked not only to protective immunity but also excessive tissue inflammation and damage in the gut and lungs. To better understand the scope and action of the IL17 family in channel catfish Ictalurus punctatus, we identified and characterized seven IL17 ligands and four IL17 receptor (IL17R) homologues from transcriptomic and genomic databases...
May 2014: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/23977238/in-vivo-delivery-of-adenoviral-vector-containing-interleukin-17-receptor-a-reduces-cardiac-remodeling-and-improves-myocardial-function-in-viral-myocarditis-leading-to-dilated-cardiomyopathy
#4
Yuquan Xie, Minghui Li, Xinggang Wang, Xian Zhang, Tianqing Peng, Yingzhen Yang, Yunzeng Zou, Junbo Ge, Haozhu Chen, Ruizhen Chen
Th17 cells have been implicated in the pathogenesis of myocarditis. Interleukin (IL)-17A produced by Th17 cells is dispensable for viral myocarditis but essential for the progression to dilated cardiomyopathy (DCM). This study investigated whether the adenoviral transfer of the IL-17 receptor A reduces myocardial remodeling and dysfunction in viral myocarditis leading to DCM. In a mouse model of Coxsackievirus B3 (CVB3)-induced chronic myocarditis, the delivery of the adenovirus-containing IL-17 receptor A (Ad-IL17RA:Fc) reduced IL-17A production and decreased the number of Th17 cells in the spleen and heart, leading to the down-regulation of systemic TNF-α and IL-6 production...
2013: PloS One
https://www.readbyqxmd.com/read/22037611/evolution-of-prokaryotic-homologues-of-the-eukaryotic-sefir-protein-domain
#5
Baojun Wu, Jing Gong, Lanlan Liu, Tianren Li, Tiandi Wei, Zengliang Bai
SEF/IL17 receptor (SEFIR) domains are mainly found in IL17 receptors (IL17Rs) and their adaptor proteins CIKS (connection to IKK and SAPK/JNK), which exert a host defense role in numbers of infectious diseases and promote inflammatory pathology in autoimmunity. Exploring the evolutionary pathway of SEFIR domains will provide further insight into their functions. Here, we have identified 84 SEFIR domain-containing proteins from more than 1400 prokaryotic genomes. As most SEFIR domain-containing bacterial genomes possess a single SEFIR encoding gene and the SEFIR protein domain forms homodimeric complexes like the Toll/IL1 receptor (TIR) domain, the single bacterial SEFIR proteins may receive binding partners from other organisms...
January 15, 2012: Gene
https://www.readbyqxmd.com/read/21732179/evolution-of-the-il17-receptor-family-in-chordates-a-new-subfamily-il17rel
#6
Baojun Wu, Meng Jin, Yi Zhang, Tiandi Wei, Zengliang Bai
The human interleukin 17 receptor (IL17R) family plays a critical role in inflammatory responses and contributes to the pathology of many autoimmune diseases. So far, five members, IL17RA to IL17RE, have been identified. Recently, some IL17R genes have been identified in non-mammalian species, such as zebrafish IL17RD; however, there are no reports on the evolutionary history of this complex gene family through comparative phylogenetic approaches. Here, we concentrated on the IL17R evolution in chordates. There are two IL17Rs in the genome of the basal chordate amphioxus: IL17RA and IL17RD...
December 2011: Immunogenetics
https://www.readbyqxmd.com/read/21367666/long-term-non-progressors-display-a-greater-number-of-th17-cells-than-hiv-infected-typical-progressors
#7
María Salgado, Norma I Rallón, Berta Rodés, Mariola López, Vincent Soriano, José Miguel Benito
Interleukin 17 (IL17) secreting T (Th17) cells play a protective role against bacterial infections at mucosal surfaces. Recent reports show Th17 cells are depleted in the gut associated lymphoid tissue of HIV+ patients, but their role in HIV disease progression is not well understood. Expression of the IL17 receptor (IL17R) and the production of IL17 were compared between two groups of HIV patients with different disease progression (long-term-nonprogressors, LTNP and typical-progressors, TP). IL17R expression was similar in LTNP and TP, whereas Th17 cell number was greater in LTNP than TP (p=0...
May 2011: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/20856230/il17-potential-therapeutic-target-in-sj%C3%A3-gren-s-syndrome-using-adenovirus-mediated-gene-transfer
#8
Cuong Q Nguyen, Hongen Yin, Byung Ha Lee, John A Chiorini, Ammon B Peck
Sjögren's syndrome (SS) involves a chronic, progressive inflammation primarily of the salivary and lacrimal glands leading to decreased levels of saliva and tears that eventually result in dry mouth and dry eye diseases. T(H)17 cell populations secreting IL17A have been shown to have an important function in an increasing number of autoimmune diseases, including SS. In this study, we investigated the function of IL17A on SS development and onset. Adenovirus-5 vectors expressing either IL17R:fragment of crystallization (Fc) fusion protein or LacZ were injected through retrograde cannulation into the salivary glands of SS-susceptible (SS(S)) C57BL/6...
January 2011: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/20038794/il-17-produced-by-neutrophils-regulates-ifn-gamma-mediated-neutrophil-migration-in-mouse-kidney-ischemia-reperfusion-injury
#9
Li Li, Liping Huang, Amy L Vergis, Hong Ye, Amandeep Bajwa, Vivek Narayan, Robert M Strieter, Diane L Rosin, Mark D Okusa
The IL-23/IL-17 and IL-12/IFN-gamma cytokine pathways have a role in chronic autoimmunity, which is considered mainly a dysfunction of adaptive immunity. The extent to which they contribute to innate immunity is, however, unknown. We used a mouse model of acute kidney ischemia-reperfusion injury (IRI) to test the hypothesis that early production of IL-23 and IL-12 following IRI activates downstream IL-17 and IFN-gamma signaling pathways and promotes kidney inflammation. Deficiency in IL-23, IL-17A, or IL-17 receptor (IL-17R) and mAb neutralization of CXCR2, the p19 subunit of IL-23, or IL-17A attenuated neutrophil infiltration in acute kidney IRI in mice...
January 2010: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/18663129/il-17-produced-by-paneth-cells-drives-tnf-induced-shock
#10
Nozomi Takahashi, Ineke Vanlaere, Riet de Rycke, Anje Cauwels, Leo A B Joosten, Erik Lubberts, Wim B van den Berg, Claude Libert
Tumor necrosis factor (TNF) has very potent antitumor activity, but it also provokes a systemic inflammatory response syndrome that leads to shock, organ failure, and death. Here, we demonstrate that interleukin (IL)-17, a proinflammatory cytokine known to be produced mainly by activated T cells, has a critical role in this process. Antiserum against IL-17 or deletion of Il17r protected mice against a lethal TNF challenge. Serum levels of TNF-induced IL-6 and nitric oxide metabolites were significantly reduced in mice deficient in the IL-17R...
August 4, 2008: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/18495731/combined-blockade-of-granulocyte-macrophage-colony-stimulating-factor-and-interleukin-17-pathways-potently-suppresses-chronic-destructive-arthritis-in-a-tumour-necrosis-factor-alpha-independent-mouse-model
#11
C Plater-Zyberk, L A B Joosten, M M A Helsen, M I Koenders, P A Baeuerle, W B van den Berg
OBJECTIVE: A pathogenic role for granulocyte-macrophage colony stimulating factor (GM-CSF) and interleukin (IL)17 in rheumatoid arthritis (RA) has been suggested. In previously published work, the therapeutic potentials of GM-CSF and IL17 blockade in arthritis have been described. In the present study, the simultaneous blockade of both pathways in a mouse model for chronic arthritis was investigated to identify whether this double blockade provides a superior therapeutic efficacy. METHODS: A chronic relapsing arthritis was induced in C57Bl/6 wild type (WT) and C57Bl/6 genetically deficient for IL17 receptor (IL17R knockout (KO)) mice by intra-articular injection of Streptococcal cell wall (SCW) fragments into knees on days 0, 7, 14 and 21...
May 2009: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/12765832/the-stir-domain-superfamily-in-signal-transduction-development-and-immunity
#12
REVIEW
Maria Novatchkova, Andreas Leibbrandt, Johannes Werzowa, Annette Neubüser, Frank Eisenhaber
We have identified a conserved sequence segment in transmembrane receptors (including SEFs, IL17Rs) and soluble factors (including CIKS/ACT1) in eukaryotes and bacteria - the SEFIR domain. This sequence domain is part of the new STIR domain superfamily comprising also the TIR domain known to mediate TIR-TIR homotypic interactions. In TOLL/IL1R-like pathways, the cytoplasmically localized TIR domain of a receptor and the TIR domain of a soluble adaptor interact physically and activate signalling. The similarity between the SEFIR and TIR domains involves the conserved boxes 1 and 2 of the TIR domain that are implicated in homotypic dimerization, but there is no sequence similarity between SEFIR domains and the TIR sequence box 3...
May 2003: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/10815801/evi27-encodes-a-novel-membrane-protein-with-homology-to-the-il17-receptor
#13
E Tian, J R Sawyer, D A Largaespada, N A Jenkins, N G Copeland, J D Shaughnessy
Evi27 is a common site of retroviral integration in BXH2 murine myeloid leukemias. Here we show that integration at Evi27 occurs in a CpG island approximately 6 kb upstream from a novel gene (designated Evii27) with homology to the IL17 receptor (Il17r) and that proviral integrations result in increased expression of the Evi27 protein on the cell surface. The human EVI27 homolog was also cloned and mapped to chromosome 3p21. Multiple Evi27 isoforms were detected at the RNA and protein level in both human and mouse, indicating that Evi27 expression is complex...
April 20, 2000: Oncogene
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