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Interleukin 23 lung cancer

Yoon Kyung Jeon, Chung Kwon Kim, Kyung Rim Hwang, Hye-Young Park, Jaemoon Koh, Doo Hyun Chung, Chang-Woo Lee, Geun-Hyoung Ha
Pellino-1 is an E3 ubiquitin ligase acting as a critical mediator for a variety of immune receptor signaling pathways, including Toll-like receptors, interleukin-1 receptor and T-cell receptors. We recently showed that the Pellino-1-transgenic (Tg) mice developed multiple tumors with different subtypes in hematolymphoid and solid organs. However, the molecular mechanism underlying the oncogenic role of Pellino-1 in solid tumors remains unknown. Pellino-1-Tg mice developed adenocarcinoma in the lungs, and Pellino-1 expression was higher in human lung adenocarcinoma cell lines compared with non-neoplastic bronchial epithelial cell lines...
March 2017: Cell Death and Differentiation
Lorena Lerner, Jeno Gyuris, Richard Nicoletti, James Gifford, Brian Krieger, Aminah Jatoi
Growth differentiating factor-15 (GDF-15), also known as macrophage inhibiting factor-1, is a member of the transforming growth factor-β superfamily, which has been implicated in cancer-associated weight loss. The present study investigated the association between cancer-associated weight loss and plasma GDF-15 concentration, as well as other biomarkers, in patients with metastatic lung or exocrine pancreatic cancer. A total of 218 patients were enrolled over a 1-year period. The patient cohort included 152 patients with incurable lung cancer and 66 patients with incurable pancreatic cancer...
November 2016: Oncology Letters
Caner Cam, Bulent Karagoz, Tuba Muftuoglu, Oguz Bigi, Levent Emirzeoglu, Serkan Celik, Alpaslan Ozgun, Tolga Tuncel, Cihan Top
AIM OF THE STUDY: Interleukin (IL)-17 and IL-23 play roles in inflammation and autoimmunity. The function of the IL-17/IL-23 pathway has not been completely evaluated in cancer patients. We aimed to investigate serum IL-17 and IL-23 levels and their relationship with clinicopathological and biochemical parameters in lung cancer patients. MATERIAL AND METHODS: Forty-five lung cancer patients and 46 healthy volunteers were included in the study. IL-17 and IL-23 measurements were made with the ELISA method...
2016: Contemporary Oncology Współczesna Onkologia
Henriette Aurora Selvik, Lars Thomassen, Anna Therese Bjerkreim, Halvor Næss
BACKGROUND: Underlying malignancy can cause ischemic stroke in some patients. Mechanisms include the affection of the coagulation cascade, tumor mucin secretion, infections and nonbacterial endocarditis. The release of necrotizing factor and interleukins may cause inflammation of the endothelial lining, creating a prothrombotic surface that triggers thromboembolic events, including stroke. The aims of this study were to assess the occurrence of cancer in patients who had recently suffered an ischemic stroke and to detect possible associations between stroke and cancer subtypes...
September 2015: Cerebrovascular Diseases Extra
Yunhui Zeng, Qiongwen Zhang, Hong Wang, Minxun Lu, Hongyu Kong, Yingyi Zhang, Huashan Shi
BACKGROUND: The prognostic significance of intratumoral and peripheral interleukin-17 (IL-17) in tumors has been studied worldwide during these years, providing un-uniformed conclusions. METHODS: We conducted a meta-analysis of published literatures that evaluated the correlation between IL-17 and clinical staging, overall survival (OS) and/or disease free survival (DFS). RESULTS: A total of 28 studies enrolling 2902 patients were included...
2015: International Journal of Clinical and Experimental Medicine
Chen Liao, Zu-Bin Yu, Gang Meng, Li Wang, Qing-Yun Liu, Liu-Tong Chen, Shuang-Shuang Feng, Hong-Bo Tu, Ya-Fei Li, Li Bai
BACKGROUND: CD4 (+) T helper 17 (Th17) cells play critical roles in inflammation and tumor development. The involvement of Th17 cells in chronic obstructive pulmonary disease (COPD)-type inflammation-associated lung cancer has also been confirmed in animal models. However, to the authors' knowledge, it is unknown whether the role of Th17 cells is different in patients with lung cancer complicated with COPD compared with those without COPD. In the current study, the authors attempted to determine the association between the circulating levels of Th17-related cytokines and the clinical characteristics of non-small cell lung cancer (NSCLC) in patients with or without COPD...
September 1, 2015: Cancer
Lei Li, Li Zhang, Dan Liu, Yue Cheng, Yu-Ting Jing, He Yu, Ping Zhou, Juan Song, Wei-Min Li
BACKGROUND: Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) is an important factor regulating protein translation. It also impacts proliferation, apoptosis, invasion, and the cell cycle of cancer cells. The aim of this study was to investigate the relationship between 4E-BP1 and human immune status, recognizing immunomodulatory molecules involved in the overexpression of 4E-BP1. METHODS: A lentivirus expression system was used to overexpress 4E-BP1 in the H1299 cell line...
July 2015: Thoracic Cancer
Min-Chao Duan, Wei Han, Pei-Wen Jin, Yu-Ping Wei, Qiu Wei, Liang-Ming Zhang, Jun-Chen Li
The fine balance of T help-17 (Th17)/regulatory T(Treg) cells is crucial for maintenance of immune homeostasis. However, there is little information concerning the role played in non-small cell lung cancer (NSCLC) by Th17/Treg cells. The objective of this study was to investigate the variation of Th17 and Treg cells in the peripheral blood of patients with NSCLC. Blood samples were collected from 19 patients with NSCLC and 19 healthy donors. Samples were processed to detect CD4(+)IL-17(+) Th17 cells and CD4(+)CD25(+)Foxp3(+) Treg cells by flow cytometry, and related gene expressions were assessed by real-time quantitative polymerase chain reaction...
December 2015: Inflammation
Jette Gjerke Hemmingsen, Kim Jantzen, Peter Møller, Steffen Loft
Exposure to traffic-related particulate matter (PM) has been associated with increased risk of lung disease, cancer and cardiovascular disease especially in elderly and overweight subjects. The proposed mechanisms involve intracellular production of reactive oxygen species (ROS), inflammation and oxidation-induced DNA damage studied mainly in young normal-weight subjects. We performed a controlled cross-over, randomised, single-blinded, repeated-measure study where 60 healthy subjects (25 males and 35 females) with age 55-83 years and body mass index above 25 kg/m(2) were exposed for 5h to either particle-filtered or sham-filtered air from a busy street with number of concentrations and PM2...
September 2015: Mutagenesis
Y Liu, X L Song, G L Zhang, A M Peng, P F Fu, P Li, M Tan, X Li, M Li, C H Wang
The results of previous case-control studies examining the relationship between the interleukin (IL)-6 gene -174G>C polymorphism and lung cancer are controversial. In this study, we evaluated the relationship between the IL-6 gene -174G>C polymorphism and lung cancer. We selected 5 case-control studies related to the IL-6 gene -174G>C polymorphism and lung cancer by searching the PubMed, EMBase, Chinese Biomedical Literature Database, and Wanfang database. We utilized the Q-test and I2 test to determine heterogeneity between each study...
2015: Genetics and Molecular Research: GMR
Te-Chun Hsia, Wen-Shin Chang, Shinn-Jye Liang, Wei-Chun Chen, Chih-Yen Tu, Hung-Jen Chen, Mei-Due Yang, Chia-Wen Tsai, Chin-Mu Hsu, Chang-Hai Tsai, Da-Tian Bau
Interleukin-10 (IL-10) is an immunosuppressive cytokine involved in carcinogenesis via immune escape. The present study aimed at evaluating the contribution of IL-10 promoter A-1082G (rs1800896), T-819C (rs3021097), A-592C (rs1800872) genetic polymorphisms to the risk of lung cancer in Taiwan. Associations of three IL-10 polymorphic genotypes with lung cancer risk were investigated among 358 lung cancer patients and 716 age- and gender-matched healthy controls. In addition, the genetic-lifestyle interaction was also examined...
December 2014: Anticancer Research
Miguel F Sanmamed, Omar Carranza-Rua, Carlos Alfaro, Carmen Oñate, Salvador Martín-Algarra, Guiomar Perez, Sara F Landazuri, Alvaro Gonzalez, Stefanie Gross, Inmaculada Rodriguez, Cecilia Muñoz-Calleja, María Rodríguez-Ruiz, Bruno Sangro, José M López-Picazo, Manglio Rizzo, Guillermo Mazzolini, Juan I Pascual, Maria Pilar Andueza, Jose Luis Perez-Gracia, Ignacio Melero
PURPOSE: Interleukin-8 (IL8) is a chemokine produced by malignant cells of multiple cancer types. It exerts various functions in shaping protumoral vascularization and inflammation/immunity. We evaluated sequential levels of serum IL8 in preclinical tumor models and in patients to assess its ability to estimate tumor burden. EXPERIMENTAL DESIGN: IL8 levels were monitored by sandwich ELISAs in cultured tumor cells supernatants, tumor-xenografted mice serum, and in samples from 126 patients with cancer...
November 15, 2014: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Britton Trabert, Ligia Pinto, Patricia Hartge, Troy Kemp, Amanda Black, Mark E Sherman, Louise A Brinton, Ruth M Pfeiffer, Meredith S Shiels, Anil K Chaturvedi, Allan Hildesheim, Nicolas Wentzensen
OBJECTIVE: Pro-inflammatory mechanisms may explain the increased ovarian cancer risk linked to more lifetime ovulations, endometriosis, and exposure to talc and asbestos, as well as decreased risk with non-steroidal anti-inflammatory drugs. Limited data are available to estimate ovarian cancer risk associated with levels of circulating inflammatory markers. METHODS: We conducted a nested case-control study within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial...
November 2014: Gynecologic Oncology
Weihua Wang, Jie Chen, Feng Zhao, Burong Zhang, Hongsheng Yu
BACKGROUND: A number of studies have examined the association between interleukin-6 (IL-6) rs1800796 polymorphism and risk of lung cancer but revealed inconsistent results. The aim of this study was to clarify the association between IL-6 rs1800796 polymorphism and risk of lung cancer. METHODS: Literature databases including PubMed, Embase and CNKI were searched up to January 2014. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) under co-dominant model, dominant model and recessive model were estimated using random-effects model...
2014: Diagnostic Pathology
Sheng Liu, Xiao-Min Wang, Guo-Wang Yang
Fuzheng Fangai pill (FZFA), a traditional Chinese formula, is widely used for cancer treatment. Compared with other anticancer drugs, it is characterized by moderate and persistent efficacy with few side effects. The present paper emphasizes antitumor effect of FZFA combined with cyclophosphamide (CTX) on C57BL/6 mice subcutaneously injected with Lewis lung cancer cells, Comparing it with that of CTX. On the 21st day, a set of biochemical parameters were studied: the tumor weight and tumor volume, the inhibition rate of lung metastasis, the percentage and ratio of spleen CD4(+)IL-17(+) Th17 (T helper cell 17, Th17 for short) and CD4(+)CD25(+)Foxp3(+) Treg (T regulatory cell, Treg for short) cells, and the concentrations of IL-6, TGF- β , IL-17, IL-23, and IFN- γ in culture supernatants of CD4(+) T lymphocytes were determined...
2014: Evidence-based Complementary and Alternative Medicine: ECAM
Sha Li, Yan Li, Xun Qu, Xiaolin Liu, Jing Liang
INTRODUCTION: The aim of this study was to explore the relationships between TregFoxP3(+) cells and Th17 cells and occurrence of lung cancer. MATERIAL AND METHODS: The proportions of TregFoxP3(+) and Th17 cells, the expression of FoxP3 and RORγt mRNA, and the levels of related cell factors such as transforming growth factor-β (TGF-β), interleukin IL-17 (IL-17) and IL-23 were determined respectively by flow cytometry analysis, real-time-polymerase chain reaction (PCR), and ELISA in peripheral blood of 18 healthy people and 26 patients with non-small cell lung cancer (NSCLC)...
May 12, 2014: Archives of Medical Science: AMS
Wei Nie, Lei Xue, Guangyuan Sun, Ye Ning, Xuewei Zhao
Several studies have examined the associations of polymorphisms in interleukin-6 (IL6) with lung cancer (LC) risk. However, the results were conflicting. Thus, a meta-analysis was conducted to determine the relationship between IL6 polymorphisms and LC risk. Databases including PubMed, EMBASE, Wanfang, and China National Knowledge Infrastructure (CNKI) were searched. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. Thirteen studies were included in this meta-analysis...
May 2014: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Johannes Vom Berg, Melissa Vrohlings, Sergio Haller, Aladin Haimovici, Paulina Kulig, Anna Sledzinska, Michael Weller, Burkhard Becher
Glioblastomas (GBs) are the most aggressive form of primary brain cancer and virtually incurable. Accumulation of regulatory T (T reg) cells in GBs is thought to contribute to the dampening of antitumor immunity. Using a syngeneic mouse model for GB, we tested whether local delivery of cytokines could render the immunosuppressive GB microenvironment conducive to an antitumor immune response. IL-12 but not IL-23 reversed GB-induced immunosuppression and led to tumor clearance. In contrast to models of skin or lung cancer, IL-12-mediated glioma rejection was T cell dependent and elicited potent immunological memory...
December 16, 2013: Journal of Experimental Medicine
Xiao-min Yang, Hua Yang
OBJECTIVE: To explore the expression of high mobility group box-1 (HMGB1) in the lung tissue and serum of patients with pulmonary tuberculosis and to explore its relationship with tumor necrosis factor (TNF)-α and interleukin(IL)-1β. METHODS: Sixty samples of lung tissues were obtained from patients with pulmonary tuberculosis who had underwent pneumonectomy in Department of Chest Surgery, First Affiliated Hospital of Zunyi Medical College from June 2010 to December 2011...
July 2013: Chinese Journal of Tuberculosis and Respiratory Diseases
Anne-Marie Baird, Eilis Dockry, Anne Daly, Emma Stack, Derek G Doherty, Kenneth J O'Byrne, Steven G Gray
The Interleukin-23 (IL-23)/IL-23R signaling axis is an important inflammatory pathway, involved in the stimulation and regulation of the T helper (Th) 17 lymphocytes, resulting in the production of IL-17. Aside from auto-immunity, this cytokine has also been linked to carcinogenesis and polymorphisms in the IL-23R gene are associated with an increased risk for the development of a number of different cancers. Activation of the IL-23 pathway results in the up-regulation of STAT3 and it is thought that the pathological consequences associated with this are in part due to the production of IL-17...
2013: Frontiers in Oncology
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