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https://www.readbyqxmd.com/read/28716816/sphingosine-1-phosphate-receptor-1-promotes-environment-induced-and-acquired-chemoresistance
#1
Veronica Lifshitz, Saul J Priceman, Wenzhao Li, Gregory Cherryholmes, Heehyoung Lee, Adar Makovski-Silverstein, Lucia Borriello, Yves A DeClerck, Hua Yu
Drug resistance is a major barrier for the development of effective and durable cancer therapies. Overcoming this challenge requires further defining the cellular and molecular mechanisms underlying drug resistance, both acquired and environment-mediated drug resistance (EMDR). Here, using neuroblastoma (NB), a childhood cancer with high incidence of recurrence due to resistance to chemotherapy, as a model we show that human bone marrow-mesenchymal stromal cells induce tumor expression of sphingosine-1-phosphate receptor-1 (S1PR1) leading to their resistance to chemotherapy...
July 17, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28708415/assessing-the-effectiveness-of-yoga-as-a-complementary-and-alternative-treatment-for-post-traumatic-stress-disorder-a-review-and-synthesis
#2
Nicole A Sciarrino, Christian DeLucia, Kaitlin O'Brien, Kristen McAdams
OBJECTIVES: Posttraumatic stress disorder (PTSD) is a debilitating condition that affects many who have experienced trauma. In addition to skills-focused treatments, exposure-based treatments, cognitive therapy, combination treatments, and EMDR, a number of alternative treatments for PTSD have emerged in recent years. The search for alternative treatments is justified based on the empirical observation that a large percentage of individuals fail to benefit optimally from existing treatments (e...
July 14, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28667881/grey-matter-density-changes-of-structures-involved-in-posttraumatic-stress-disorder-ptsd-after-recovery-following-eye-movement-desensitization-and-reprocessing-emdr-therapy
#3
Sarah Boukezzi, Myriam El Khoury-Malhame, Guillaume Auzias, Emmanuelle Reynaud, Pierre-François Rousseau, Emmanuel Richard, Xavier Zendjidjian, Jacques Roques, Nathalie Castelli, Nadia Correard, Valérie Guyon, Caroline Gellato, Jean-Claude Samuelian, Aida Cancel, Magali Comte, Marianne Latinus, Eric Guedj, Stéphanie Khalfa
Recovery of stress-induced structural alterations in Posttraumatic Stress Disorder (PTSD) remains largely unexplored. This study aimed to determine whether symptoms improvement is associated with grey matter (GM) density changes of brain structures involved in PTSD. Two groups of PTSD patients were involved in this study. The first group was treated with Eye Movement Desensitization and Reprocessing (EMDR) therapy and recovered from their symptoms (recovery group) (n = 11); Patients were scanned prior to therapy (T1), one week (T2) and five months after the end of therapy (T3)...
June 19, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28660669/comparison-of-eye-movement-desensitization-and-reprocessing-therapy-cognitive-behavioral-writing-therapy-and-wait-list-in-pediatric-posttraumatic-stress-disorder-following-single-incident-trauma-a-multicenter-randomized-clinical-trial
#4
Carlijn de Roos, Saskia van der Oord, Bonne Zijlstra, Sacha Lucassen, Sean Perrin, Paul Emmelkamp, Ad de Jongh
BACKGROUND: Practice guidelines for childhood posttraumatic stress disorder (PTSD) recommend trauma-focused psychotherapies, mainly cognitive behavioral therapy (CBT). Eye movement desensitization and reprocessing (EMDR) therapy is a brief trauma-focused, evidence-based treatment for PTSD in adults, but with few well-designed trials involving children and adolescents. METHODS: We conducted a single-blind, randomized trial with three arms (n = 103): EMDR (n = 43), Cognitive Behavior Writing Therapy (CBWT; n = 42), and wait-list (WL; n = 18)...
June 28, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28659851/bilateral-alternating-auditory-stimulations-facilitate-fear-extinction-and-retrieval
#5
Sarah Boukezzi, Catarina Silva, Bruno Nazarian, Pierre-François Rousseau, Eric Guedj, Camila Valenzuela-Moguillansky, Stéphanie Khalfa
Disruption of fear conditioning, its extinction and its retrieval are at the core of posttraumatic stress disorder (PTSD). Such deficits, especially fear extinction delay, disappear after alternating bilateral stimulations (BLS) during eye movement desensitization and reprocessing (EMDR) therapy. An animal model of fear recovery, based on auditory cued fear conditioning and extinction learning, recently showed that BLS facilitate fear extinction and fear extinction retrieval. Our goal was to determine if these previous results found in animals can be reproduced in humans...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28656479/-emdr-as-a%C3%A2-psychotherapeutic-approach-in-the-treatment-of-chronic-pain-is-eye-movement-desensitization-and-reprocessing-an-effective-therapy-for-patients-with-chronic-pain-who-do-not-suffer-from-posttraumatic-stress-disorder
#6
REVIEW
M Wicking, C Maier, J Tesarz, K Bernardy
The efficacy of Eye Movement Desensitization and Reprocessing (EMDR) has been demonstrated for posttraumatic stress disorder. Despite promising research, it is still not clear if EMDR is a similarly effective treatment for chronic pain. Controlled trials are lacking and whether specific mechanisms underlie the effects remains unknown. The treatment of chronic pain aims at a reduction of subjective pain sensations. To achieve this goal without the usage of pain medications, i. e. through psychotherapy, is desirable for many reasons (e...
June 27, 2017: Der Schmerz
https://www.readbyqxmd.com/read/28649868/early-eye-movement-desensitisation-and-reprocessing-emdr-intervention-in-a-disaster-mental-health-care-context
#7
Anna Saltini, Daniela Rebecchi, Chiara Callerame, Isabel Fernandez, Elisa Bergonzini, Fabrizio Starace
'Early psychological intervention' is defined as commencing treatment within three months of the traumatic event, with the aim to prevent or treat posttraumatic stress disorder, ongoing distress or acute stress disorder. In natural disaster situations, specific issues may limit the amount of time available for treatment and the possibility of interventions. Eye Movement Desensitisation and Reprocessing (EMDR) can be used without regard to these limits. The aim of the study is to evaluate the effects of EMDR, Recent Traumatic Episode Protocol (R-TEP) provided within three months of the traumatic event to a large sample of individuals exposed to the earthquake that hit Emilia Romagna Region (Northern Italy) in 2012...
June 25, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28506142/the-frustrated-and-helpless-healer-pathways-approaches-to-posttraumatic-stress-disorders
#8
Donald Moss
Posttraumatic stress disorder is a psychophysiological disorder, characterized by the following: chronic sympathetic nervous activation; persisting perceptual/sensory vigilance for threats; recurrent distressing memories of the event, including intrusive memories, flashbacks lived as if in the present moment, and nightmares; and a persisting negative emotional state including fear and shame. The psychophysiological basis for this disorder calls for psychophysiologically based interventions. This article presents the case narrative of a 29-year-old national guardsman, exposed to combat trauma and later to civilian trauma in public safety work...
July 2017: International Journal of Clinical and Experimental Hypnosis
https://www.readbyqxmd.com/read/28485636/a-systematic-review-of-psychosocial-interventions-for-adult-refugees-and-asylum-seekers
#9
Rachel H Tribe, Kyra-Verena Sendt, Derek K Tracy
BACKGROUND: Europe is in the midst of the largest refugee migration since the Second World War; there is an urgent need to provide an updated systematic review of the current best evidence for managing mental distress in refugee populations. AIMS: The aim of this review is to provide an exhaustive summary of the current literature on psychosocial interventions, both trauma- and non-trauma-focused, for refugee populations experiencing post-traumatic stress disorder (PTSD), depressive or anxiety symptoms...
May 9, 2017: Journal of Mental Health
https://www.readbyqxmd.com/read/28472933/imagery-rescripting-and-eye-movement-desensitisation-and-reprocessing-for-treatment-of-adults-with-childhood-trauma-related-post-traumatic-stress-disorder-irem-study-design
#10
Katrina L Boterhoven de Haan, Christopher W Lee, Eva Fassbinder, Marisol J Voncken, Mariel Meewisse, Saskia M Van Es, Simone Menninga, Margriet Kousemaker, Arnoud Arntz
BACKGROUND: Post-traumatic stress disorder (PTSD) that originates from childhood trauma experiences can develop into a chronic condition that has lasting effects on an individual's functioning and quality of life. While there are evidence-based guidelines for treating adult onset PTSD, treatments for adults with childhood trauma-related PTSD (Ch-PTSD) are varied and subject to ongoing debate. This study will test the effectiveness of two trauma-focused treatments, imagery rescripting (ImRs) and eye movement desensitisation and reprocessing (EMDR) in participants with Ch-PTSD...
May 4, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28456330/the-effects-of-%C3%AE-adrenergic-blockade-on-the-degrading-effects-of-eye-movements-on-negative-autobiographical-memories
#11
Marianne Littel, J Leon Kenemans, Johanna M P Baas, H N Alexander Logemann, Nellie Rijken, Malou Remijn, Rutger J Hassink, Iris M Engelhard, Marcel A van den Hout
BACKGROUND: Eye movement desensitization and reprocessing (EMDR) is an effective treatment for posttraumatic stress disorder. During EMDR, patients make horizontal eye movements (EMs) while simultaneously recalling a traumatic memory, which renders the memory less vivid and emotional when it is later recalled again. Recalling highly emotional autobiographical memories enhances noradrenergic neurotransmission. Noradrenaline (NA) strengthens memory (re)consolidation. However, memories become less vivid after recall+EMs...
March 28, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28397633/psychosocial-interventions-for-children-and-adolescents-after-man-made-and-natural-disasters-a-meta-analysis-and-systematic-review
#12
R C Brown, A Witt, J M Fegert, F Keller, M Rassenhofer, P L Plener
Children and adolescents are a vulnerable group to develop post-traumatic stress symptoms after natural or man-made disasters. In the light of increasing numbers of refugees under the age of 18 years worldwide, there is a significant need for effective treatments. This meta-analytic review investigates specific psychosocial treatments for children and adolescents after man-made and natural disasters. In a systematic literature search using MEDLINE, EMBASE and PsycINFO, as well as hand-searching existing reviews and contacting professional associations, 36 studies were identified...
April 11, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28376919/eye-movement-desensitization-and-reprocessing-therapy-versus-supportive-therapy-in-affective-relapse-prevention-in-bipolar-patients-with-a-history-of-trauma-study-protocol-for-a-randomized-controlled-trial
#13
Ana Moreno-Alcázar, Joaquim Radua, Ramon Landín-Romero, Laura Blanco, Mercè Madre, Maria Reinares, Mercè Comes, Esther Jiménez, Jose Manuel Crespo, Eduard Vieta, Victor Pérez, Patricia Novo, Marta Doñate, Romina Cortizo, Alicia Valiente-Gómez, Walter Lupo, Peter J McKenna, Edith Pomarol-Clotet, Benedikt L Amann
BACKGROUND: Up to 60% of patients with bipolar disorder (BD) have a history of traumatic events, which is associated with greater episode severity, higher risk of comorbidity and higher relapse rates. Trauma-focused treatment strategies for BD are thus necessary but studies are currently scarce. The aim of this study is to examine whether Eye Movement Desensitization and Reprocessing (EMDR) therapy focusing on adherence, insight, de-idealisation of manic symptoms, prodromal symptoms and mood stabilization can reduce episode severity and relapse rates and increase cognitive performance and functioning in patients with BD...
April 4, 2017: Trials
https://www.readbyqxmd.com/read/28373235/emdr-therapy-for-schizophrenia-and-other-psychoses
#14
Vishal Bhavsar
No abstract text is available yet for this article.
April 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28368869/efficacy-of-eye-movement-desensitization-and-reprocessing-on-the-phantom-limb-pain-of-patients-with-amputations-within-a-24-month-follow-up
#15
Akbar Rostaminejad, Mohammad Behnammoghadam, Marzieh Rostaminejad, Zargham Behnammoghadam, Somaye Bashti
The aim of this study was to evaluate the efficacy of eye movement desensitization and reprocessing (EMDR) on the phantom limb pain (PLP) of patients with amputations within a 24-month follow-up. This study was a randomized-controlled trial. A total of 60 patients with amputations were selected by a purposive sampling and patients were divided randomly into two experimental and control groups. Samples were assigned through randomized allocation. EMDR therapy was administered individually to the experimental group participants in 12 one-hour sessions over a 1-month period, In each session, the patient completed the Subjective Units of Distress Scale and a pain-rating scale before and after the intervention...
April 7, 2017: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/28348720/the-optimum-study-emdr-therapy-in-pregnant-women-with-posttraumatic-stress-disorder-after-previous-childbirth-and-pregnant-women-with-fear-of-childbirth-design-of-a-multicentre-randomized-controlled-trial
#16
M A M Baas, C A I Stramrood, L M Dijksman, A de Jongh, M G van Pampus
Background: Approximately 3% of women develop posttraumatic stress disorder (PTSD) after giving birth, and 7.5% of pregnant women show a pathological fear of childbirth (FoC). FoC or childbirth-related PTSD during (a subsequent) pregnancy can lead to a request for an elective caesarean section as well as adverse obstetrical and neonatal outcomes. For PTSD in general, and several subtypes of specific phobia, eye movement desensitization and reprocessing (EMDR) therapy has been proven effective, but little is known about the effects of applying EMDR during pregnancy...
2017: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/28345176/eye-movement-desensitisation-and-reprocessing-therapy-for-posttraumatic-stress-disorder-in-a-child-and-an-adolescent-with-mild-to-borderline-intellectual-disability-a-multiple-baseline-across-subjects-study
#17
Liesbeth Mevissen, Robert Didden, Hubert Korzilius, Ad de Jongh
BACKGROUND: This study explored the effectiveness of eye movement desensitisation and reprocessing (EMDR) therapy for post-traumatic stress disorder (PTSD) in persons with mild to borderline intellectual disability (MBID) using a multiple baseline across subjects design. METHODS: One child and one adolescent with MBID, who met diagnostic criteria for PTSD according to a PTSD clinical interview (i.e., ADIS-C PTSD section), adapted and validated for this target group, were offered four sessions of EMDR...
March 26, 2017: Journal of Applied Research in Intellectual Disabilities: JARID
https://www.readbyqxmd.com/read/28315585/eye-movement-during-recall-reduces-objective-memory-performance-an-extended-replication
#18
Arne Leer, Iris M Engelhard, Bert Lenaert, Dieter Struyf, Bram Vervliet, Dirk Hermans
Eye Movement Desensitization and Reprocessing (EMDR) therapy for posttraumatic stress disorder involves making eye movements (EMs) during recall of a traumatic image. Experimental studies have shown that the dual task decreases self-reported memory vividness and emotionality. However valuable, these data are prone to demand effects and little can be inferred about the mechanism(s) underlying the observed effects. The current research aimed to fill this lacuna by providing two objective tests of memory performance...
March 9, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28302084/effectiveness-of-emdr-in-patients-with-substance-use-disorder-and-comorbid-ptsd-study-protocol-for-a-randomized-controlled-trial
#19
Ingo Schäfer, Laycen Chuey-Ferrer, Arne Hofmann, Peter Lieberman, Günter Mainusch, Annett Lotzin
BACKGROUND: Eye Movement Desensitization and Reprocessing (EMDR) is an evidence-based treatment for PTSD. However, it is unclear whether EMDR shows the same effectiveness in patients with substance use disorders (SUD) and comorbid PTSD. In this trial, we examine the effectiveness of EMDR in reducing PTSD symptoms in patients with SUD and PTSD. METHODS/DESIGN: We conduct a single-blinded RCT among 158 patients with SUD and comorbid PTSD admitted to a German addiction rehabilitation center specialized for the treatment of patients with SUD and comorbid PTSD...
March 16, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28287194/-modifiche-morfo-volumetriche-dopo-trattamento-emdr-in-pazienti-drug-na%C3%A3-ve-affetti-da-dpts
#20
Letizia Bossini, Emiliano Santarnecchi, Ilaria Casolaro, Despoina Koukouna, Claudia Caterini, Federica Cecchini, Valentina Fortini, Giampaolo Vatti, Daniela Marino, Isabel Fernandez, Alessandro Rossi, Andrea Fagiolini
RIASSUNTO. Introduzione. Esistono pochi studi che hanno indagato gli effetti di una psicoterapia ritenuta efficace sulle alterazioni strutturali delle regioni cerebrali associate al disturbo da stress post-traumatico (PTSD). Ci siamo, pertanto, proposti di valutare gli effetti neurobiologici della terapia EMDR su un gruppo di 19 pazienti con PTSD, senza cura farmacologica e senza alcuna comorbidità con altri disturbi psichiatrici, a confronto con un gruppo di controllo costituito da 19 soggetti sani non trattati...
January 2017: Rivista di Psichiatria
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