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https://www.readbyqxmd.com/read/28645071/television-viewing-and-risk-of-mortality-exploring-the-biological-plausibility
#1
Mark Hamer, Thomas Yates, Panayotes Demakakos
BACKGROUND AND AIMS: Television (TV) viewing is a major component of leisure sedentary time, and has been consistently associated with cardiovascular disease. We examined the extent to which metabolic biomarkers explain the association between TV viewing and mortality. METHODS: Participants (N = 8,451, aged 64.8 ± 9.9 yrs) were drawn from The English Longitudinal Study of Ageing (ELSA), a national prospective cohort study of community-dwelling men and women living in England...
June 9, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28644050/hba1c-analysis-by-capillary-electrophoresis-comparison-with-chromatography-and-an-immunological-method
#2
Olav Klingenberg, Torill Furuset, Camilla R Hestbråten, Marit H Hallberg, Astrid Steiro, Iren R Orset, Jens P Berg
BACKGROUND: Haemoglobin A1c (HbA1c) has become an even more important analyte for clinical laboratories during recent years with the introduction of its diagnostic use for diabetes mellitus. Several different analytical principles can be used, each with their advantages and disadvantages. AIM: We wanted to compare Sebia Capillarys 2 Flex Piercing (Capillarys) with our routine HbA1c methods, which were an HPLC method (Tosoh G7) and an immunoassay (Tina-Quant on Roche Modular P) by analysing a large clinical material...
June 23, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28643877/cerebral-haemodynamic-response-to-somatosensory-stimulation-in-neonatal-lambs
#3
Shinji Nakamura, David W Walker, Flora Y Wong
The neurovascular coupling response has been defined for the adult brain but in the neonate non-invasive measurement of local cerebral perfusion using NIRS or BOLD fMRI have yielded variable and inconsistent results, including negative responses suggesting decreased perfusion and localised tissue tissue hypoxia. Also, the impact of permissive hypercapnia (Pa CO2  > 50 mmHg) in the management of neonates on cerebrovascular responses to somatosensory input is unknown. Using NIRS to measure changes in cerebral oxy- and deoxy-haemoglobin (ΔoxyHb, ΔdeoxyHb) in 8 anaesthetised newborn lambs, we studied the cerebral haemodynamic functional response to left median nerve stimulation using stimulus trains of 1...
June 23, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28643629/faecal-immunochemical-tests-to-triage-patients-with-lower-abdominal-symptoms-for-suspected-colorectal-cancer-referrals-in-primary-care-a-systematic-review-and-cost-effectiveness-analysis
#4
Marie Westwood, Isaac Corro Ramos, Shona Lang, Marianne Luyendijk, Remziye Zaim, Lisa Stirk, Maiwenn Al, Nigel Armstrong, Jos Kleijnen
BACKGROUND: Colorectal cancer (CRC) is the third most common cancer in the UK. Presenting symptoms that can be associated with CRC usually have another explanation. Faecal immunochemical tests (FITs) detect blood that is not visible to the naked eye and may help to select patients who are likely to benefit from further investigation. OBJECTIVES: To assess the effectiveness of FITs [OC-Sensor (Eiken Chemical Co./MAST Diagnostics, Tokyo, Japan), HM-JACKarc (Kyowa Medex/Alpha Laboratories Ltd, Tokyo, Japan), FOB Gold (Sentinel/Sysmex, Sentinel Diagnostics, Milan, Italy), RIDASCREEN Hb or RIDASCREEN Hb/Hp complex (R-Biopharm, Darmstadt, Germany)] for primary care triage of people with low-risk symptoms...
May 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28643616/advanced-neuroimaging-of-carbon-monoxide-poisoning
#5
Marco Varrassi, Alessandra Di Sibio, Camilla Gianneramo, Marco Perri, Giorgia Saltelli, Alessandra Splendiani, Carlo Masciocchi
Carbon monoxide (CO) inhalation is nowadays the most common cause of fatal poisoning worldwide. CO binds to haemoglobin 230-270 times more avidly than oxygen, thus leading to formation of carboxyhaemoglobin with subsequent reduction of tissue oxygenation. Brain is mainly affected due to its high oxygen requirement. Up to two-thirds of patients who survive the acute phase of this pathology present a delayed leukoencephalopathy, usually in a period ranging from two to 40 days. White matter damage closely relates to long-term prognosis of these patients...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28643346/red-blood-cells-free-%C3%AE-haemoglobin-pool-a-biomarker-to-monitor-the-%C3%AE-thalassemia-intermedia-variability-the-alphapool-study
#6
Corinne Vasseur, Elisa Domingues-Hamdi, Katia Ledudal, Philippe Le Corvoisier, Caroline Barau, Bijan Ghaleh, Amandine Rialland, Serge Pissard, Frédéric Galactéros, Véronique Baudin-Creuza
The severity of β-thalassaemia (β-thal) intermedia is mainly correlated to the degree of imbalanced α/non α-globin chain synthesis. The phenotypic diversity of β-thal depends on this imbalance and reflects all possible combinations of α- and β-globin genotypes, levels of fetal haemoglobin (HbF) and co-inheritance of other modulating factors. This study aimed to demonstrate the validity of a new surrogate of α/non α-globin biosynthetic ratio by measuring the soluble α-Hb pool in lysed red blood cells...
June 23, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28639693/thromboelastography-may-predict-risk-of-grade-2-bleeding-in-thrombocytopenic-patients
#7
E N Opheim, T O Apelseth, S J Stanworth, G E Eide, T Hervig
BACKGROUND AND OBJECTIVES: Platelet count is used as a prophylactic platelet transfusion trigger, although evidence suggests that it is a poor predictor of bleeding. Thus, alternative tests are required. The primary objective of this study was to compare thromboelastography (TEG) parameters on days with and without bleeding symptoms. The secondary objectives were to investigate the relationship between TEG parameters and haematological variables, fever, C-reactive protein (CRP) and platelet transfusion...
June 22, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28639502/rituximab-as-first-line-treatment-for-acquired-thrombotic-thrombocytopenic-purpura
#8
Haifei Chen, Ailin Fu, Jing Wang, Tianqin Wu, Zhengyang Li, Jieqing Tang, Hongshi Shen, Jingjing Zhu, Jie Li, Qian Zhu, Longmei Qing
Objective To investigate the efficacy and safety of rituximab (RTX) as first-line treatment of acquired thrombotic thrombocytopenic purpura (aTTP). Methods Twenty-five patients with acute aTTP and/or severe a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) deficiency were admitted to our centre from April 2009 to March 2015. Fourteen patients received RTX plus standard therapy (plasma exchange and corticosteroids) at acute episodes. Haemoglobin, platelet count, schistocytes, lactate dehydrogenase levels, ADAMTS13 activity and its inhibitors, and the ratio of B lymphocytes in the peripheral blood, were monitored...
June 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28637595/a-one-year-mortality-clinical-prediction-rule-for-patients-with-heart-failure
#9
Antonio Escobar, Lidia García-Pérez, Gemma Navarro, Amaia Bilbao, Raul Quiros
AIMS: To create and validate a clinical prediction rule which is easy to manage, reproducible and that allows classifying patients admitted for heart failure according to their one-year mortality risk. METHODS: A prospective cohort study carried out with 2565 consecutive patients admitted with heart failure in 13 hospitals in Spain. The derivation cohort was made up of 1283 patients and 1282 formed the validation cohort. In the derivation cohort, we carried out a multivariate logistic model to predict one-year mortality...
June 18, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28636166/could-intradialytic-nutrition-improve-refractory-anaemia-in-patients-undergoing-haemodialysis
#10
Ahmad F Thabet, Sawsan M Moeen, Mohammed O Labiqe, Medhat A Saleh
BACKGROUND: This prospective randomised study was designed to evaluate the efficacy of intradialytic parenteral nutrition (IDPN) therapy in malnourished patients with refractory anaemia. METHODS: Forty patients who were malnourished with a BMI not greater than 23 (17-23) kg/m(2) , undergoing regular HD were included. Of those, 20 patients received 500-1000 ml of IDPN at a rate of 250-300 ml/h at each HD session three days per week for six consecutive months...
June 21, 2017: Journal of Renal Care
https://www.readbyqxmd.com/read/28635634/despite-inflammation-supplemented-essential-amino-acids-may-improve-circulating-levels-of-albumin-and-haemoglobin-in-patients-after-hip-fractures
#11
Roberto Aquilani, Ginetto Carlo Zuccarelli, Anna Maria Condino, Michele Catani, Carla Rutili, Consiglia Del Vecchio, Pietro Pisano, Manuela Verri, Paolo Iadarola, Simona Viglio, Federica Boschi
Essential amino acids (EAAs) are nutritional substrates that promote body protein synthesis; thus we hypothesised that their supplementation may improve circulating albumin (Alb) and haemoglobin (Hb) in rehabilitative elderly patients following hip fractures (HF). Out of the 145 HF patients originally enrolled in our study, 112 completed the protocol. These subjects were divided into two randomised groups, each containing 56 patients. For a period of two months, one group (age 81.4 ± 8.1 years; male/female 27/29) received a placebo, and the other (age 83...
June 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28633604/a-two-stage-approach-to-the-joint-analysis-of-longitudinal-and-survival-data-utilising-the-coxian-phase-type-distribution
#12
Conor Donnelly, Lisa M McFetridge, Adele H Marshall, Hannah J Mitchell
The Coxian phase-type distribution is a special type of Markov model which can be utilised both to uncover underlying stages of a survival process and to make inferences regarding the rates of flow of individuals through these latent stages before an event of interest occurs. Such models can be utilised, for example, to identify individuals who are likely to deteriorate faster through a series of disease states and thus require more aggressive medical intervention. Within this paper, a two-stage approach to the analysis of longitudinal and survival data is presented...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/28630674/cation-effects-on-haemoglobin-aggregation-balance-of-chemisorption-against-physisorption-of-ions
#13
Drew F Parsons, Timothy T Duignan, Andrea Salis
A theoretical model of haemoglobin is presented to explain an anomalous cationic Hofmeister effect observed in protein aggregation. The model quantifies competing proposed mechanisms of non-electrostatic physisorption and chemisorption. Non-electrostatic physisorption is stronger for larger, more polarizable ions with a Hofmeister series Li(+)< K(+)< Cs(+). Chemisorption at carboxylate groups is stronger for smaller kosmotropic ions, with the reverse series Li(+) > K(+) > Cs(+). We assess aggregation using second virial coefficients calculated from theoretical protein-protein interaction energies...
August 6, 2017: Interface Focus
https://www.readbyqxmd.com/read/28629680/preoperative-embolization-in-spinal-tumour-surgery-enhancing-its-effectiveness
#14
Barry Wei Loong Tan, Aye Sandar Zaw, Prapul Chander Rajendran, John Nathaniel Ruiz, Naresh Kumar, Gopinathan Anil
We conducted a retrospective review of 221 patients, who underwent spinal oncologic surgery at a tertiary university hospital between 2005 and 2014; in order to identify and validate factors that influence the impact of preoperative embolization of spinal tumours on outcome measures of blood loss and transfusion requirements in spinal oncologic surgery. We also focused on primary tumour type and type of spinal surgery performed. Patients' electronic and physical records were reviewed to provide demographic data, tumour characteristics, embolization techniques and surgical procedure details...
June 16, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28627052/influence-of-different-protein-sources-in-the-broiler-diet-on-the-presence-of-campylobacter-spp-in-excreta-and-caecal-content
#15
C F Visscher, A Abd El-Wahab, M F E Ahmed, J Hankel, V Taube, J Kamphues
The aim of the present study was to examine possible effects of a different protein supply on the presence of Campylobacter in excreta and caecal content of broiler chickens. Therefore, 220 one-day-old chickens were fed five different diets in the experimental period (day 8 onwards). In the control group (CON; n = 3 boxes), a soya bean-based industrially produced complete diet containing 5-10% whole wheat and coccidiostats was fed, whereas in the remaining groups, four own-made complete diets with four protein sources and combinations (4 × 2 boxes; soya bean meal-based diet = SBM; rapeseed meal-containing diet = RSM; haemoglobin meal-containing diet = HGP; algae-containing diet = ALG) were offered...
June 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28626873/assessing-prefrontal-cortex-oxygenation-after-sport-concussion-with-near-infrared-spectroscopy
#16
Scott A Bishop, J Patrick Neary
BACKGROUND: Clinicians typically rely on neuropsychological and balance tests to track concussion recovery. The aforementioned tests imply impairments that are based on performance, but these tests do not directly measure brain physiology throughout concussion recovery. Because of these issues, an objective biomarker that can index severity and the recovery timeline is needed. Moreover, the number of concussions occurring at a recreational level requires the biomarker to be easily administered in a cost effective manner, and the results easily interpreted...
June 18, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28625039/cooking-methods-and-depressive-symptoms-are-joint-risk-factors-for-fatigue-among-migrant-indonesian-women-working-domestically-in-taiwan
#17
Khairizka Citra Palupi, Chun-Kuang Shih, Jung-Su Chang
BACKGROUND AND OBJECTIVES: Fatigue is a critical occupational health risk among migrant workers. Globally, more than half of migrant workers are women. However, the prevalence rate and risk factors for fatigue in domestically employed migrant women are unknown. METHODS AND STUDY DESIGN: In total, 194 Indonesian women migrants aged 20-50 years who were working in Taipei were studied. Self-perceived acculturation, dietary acculturation, BMI and haemoglobin were evaluated...
June 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28622365/association-between-socioeconomic-deprivation-and-colorectal-cancer-screening-outcomes-low-uptake-rates-among-the-most-and-least-deprived-people
#18
Andrea Buron, Josep M Auge, Maria Sala, Marta Román, Antoni Castells, Francesc Macià, Mercè Comas, Carolina Guiriguet, Xavier Bessa, Xavier Castells
BACKGROUND: Screening with faecal occult blood tests reduces colorectal cancer-related mortality; however, age, sex and socioeconomic factors affect screening outcomes and could lead to unequal mortality benefits. The aim of this study was to describe the main outcomes of the population-based Barcelona colorectal cancer screening programme (BCRCSP) by deprivation. METHODS: Retrospective study of the eligible population of the first round of the BCRCSP. Participants' postal addresses were linked with the MEDEA database to obtain the deprivation quintiles (Dq)...
2017: PloS One
https://www.readbyqxmd.com/read/28621491/outcome-of-patients-older-than-80%C3%A2-years-with-diffuse-large-b-cell-lymphoma-dlbcl-treated-with-standard-immunochemotherapy-a-large-retrospective-study-from-4-institutions
#19
Stefania Gobba, Alden A Moccia, Wiebke Gulden-Sala, Annarita Conconi, Stefan Diem, Luciano Cascione, Gloria Iacoboni, Gloria Margiotta-Casaluci, Kathrin Aprile von Hohenstaufen, Anastasios Stathis, Felicitas Hitz, Graziella Pinotti, Gianluca Gaidano, Emanuele Zucca
Little information is available on the very elderly patients with diffuse large B-cell lymphoma (DLBCL). We performed a retrospective analysis of 281 patients >80 years old with newly diagnosed DLBCL treated in 4 referral institutions in Switzerland and Northern Italy. Primary end points were overall survival, progression-free survival, and cause-specific survival. Systemic chemotherapy was given to 239 patients, and 119 of them received rituximab in their initial treatment. At a median follow-up of 5.5 years, 5-year progression-free survival was 26% (95% confidence interval [CI], 20-32%), 5-year overall survival was 31% (95% CI, 25-37%), and 5-year cause-specific survival was 48% (95% CI, 41-55%) for the entire cohort...
June 16, 2017: Hematological Oncology
https://www.readbyqxmd.com/read/28621148/association-between-cognitive-vulnerability-to-depression%C3%A2-%C3%A2-dysfunctional-attitudes-and-glycaemic-control-among-in-patients-with-type-2-diabetes-in-a-hospital-in-beijing-a-multivariate-regression-analysis
#20
Yue Ma, Xun Li, Dandan Zhao, Rui Wu, Hongfeng Sun, Shibo Chen, Linyun Wang, Xue Fang, Jin Huang, Xia Li, Ying Zhang, Guangjian Jiang, Dongwei Zhang, Yanyun Pan, Tian An, Yue Shi, Jiacheng Zuo, Na Yu, Sihua Gao
This cross-sectional study aimed to investigate the relationship between glycosylated haemoglobin (HbA1c) and cognitive vulnerability to depression (dysfunctional attitudes) in patients with type 2 diabetes mellitus. A total of 245 valid records from June 2016 to December 2016 were collected from a hospital in Beijing. Participants were asked to complete four questionnaires (Dysfunctional Attitudes Scale, Automatic Thoughts Questionnaire, Zung Self-rating Depression Scale, and World Health Organization Quality of Life Instrument-Short Form) to assess mental health and quality of life...
June 16, 2017: Psychology, Health & Medicine
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