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https://www.readbyqxmd.com/read/28933328/-local-application-of-tranexamic-acid-in-total-hip-arthroplasty-decreases-blood-loss-and-consumption-of-blood-transfusion
#1
J Lošťák, J Gallo, M Večeřa, J Špička, K Langová
PURPOSE OF THE STUDY The primary aim of our study was to identify the effects of local application of tranexamic acid (TXA, Exacyl) on the amount of postoperative blood loss and blood transfusion requirement in primary total hip arthroplasty. We also recorded the levels of postoperative haemoglobin and its drop in early period after surgery. In each patient, we monitored in detail the incidence of early complications (haematoma, wound exudate). Lastly, the economic aspect of TXA administration was also taken into account...
2017: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28932684/value-of-combining-dynamic-contrast-enhanced-ultrasound-and-optoacoustic-tomography-for-hypoxia-imaging
#2
Anant Shah, Nigel Bush, Gary Box, Suzanne Eccles, Jeffrey Bamber
Optoacoustic imaging (OAI) can detect haemoglobin and assess its oxygenation. However, the lack of a haemoglobin signal need not indicate a lack of perfusion. This study uses a novel method to assist the co-registration of optoacoustic images with dynamic contrast enhanced ultrasound (DCE-US) images to demonstrate, in preclinical tumour models, the value of combining haemoglobin imaging with a perfusion imaging method, showing that a lack of a haemoglobin signal does not necessarily indicate an absence of perfusion...
December 2017: Photoacoustics
https://www.readbyqxmd.com/read/28932397/undiagnosed-and-diagnosed-diabetes-mellitus-among-hospitalised-acute-heart-failure-patients-in-botswana
#3
Julius Chacha Mwita, Mgaywa Gilbert Mjungu Damas Magafu, Bernard Omech, Billy Tsima, Matthew J Dewhurst, Monkgogi Goepamang, Yohana Mashalla
OBJECTIVE: The objective of this study was to determine the burden of diagnosed and undiagnosed type 2 diabetes mellitus among patients hospitalised with acute heart failure in Botswana. METHODS: The study enrolled 193 consecutive patients admitted with acute heart failure to the medical wards at Princess Marina Hospital in Gaborone. Patients were classified as previously known diabetics, undiagnosed diabetics (glycated haemoglobin ≥ 6.5%) or as non-diabetics (glycated haemoglobin < 6...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28931618/predicting-major-bleeding-in-ischemic-stroke-patients-with-atrial-fibrillation
#4
Nina A Hilkens, Ale Algra, Jacoba P Greving
BACKGROUND AND PURPOSE: Performance of risk scores for major bleeding in patients with atrial fibrillation and a previous transient ischemic attack or ischemic stroke is not well established. We aimed to validate risk scores for major bleeding in patients with atrial fibrillation treated with oral anticoagulants after cerebral ischemia and explore the net benefit of oral anticoagulants among bleeding risk categories. METHODS: We analyzed 3623 patients with a history of transient ischemic attack or stroke included in the RE-LY trial (Randomized Evaluation of Long-Term Anticoagulation Therapy)...
September 20, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28930726/uk-renal-registry-19th-annual-report-chapter-7-haemoglobin-ferritin-and-erythropoietin-amongst-uk-adult-dialysis-patients-in-2015-national-and-centre-specific-analyses
#5
https://www.readbyqxmd.com/read/28929623/influence-of-combined-iron-supplementation-and-simulated-hypoxia-on-the-haematological-module-of-the-athlete-biological-passport
#6
Laura A Garvican-Lewis, Victor L Vuong, Andrew D Govus, Yorck Olaf Schumacher, David Hughes, Greg Lovell, Daniel Eichner, Christopher J Gore
The integrity of Athlete Biological Passport (ABP) is underpinned by understanding normal fluctuations of its biomarkers to environmental or medical conditions, e.g. altitude training or iron deficiency. The combined impact of altitude and iron supplementation on the ABP was evaluated in endurance-trained athletes (n=34) undertaking 3-weeks of simulated live-high: train-low (14 h.d(-1) , 3000m). Athletes received either oral, intravenous (IV) or placebo iron supplementation, commencing two weeks prior and continuing throughout hypoxic exposure...
September 19, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28929118/natriuretic-peptide-system-activation-in-acute-heart-failure-patients-with-diabetes
#7
Filipe M Cunha, Joana Pereira, Pedro Marques, Helena Moreira, Pedro Rodrigues, Maria João Pinto, Patrícia Lourenço, Paulo Bettencourt
BACKGROUND: Elevated B-type natriuretic peptide (BNP) is a hallmark in heart failure (HF). Diabetic patients with chronic HF seem to have higher BNP than nondiabetics. We studied, in acute HF, if BNP levels are different between diabetics and nondiabetics. METHODS: From a prospectively recruited population of acute HF patients, we selected a convenience sample. In pair-matched analysis, each diabetic patient was matched with a nondiabetic of the same age (±1 year), gender, and according to left ventricular systolic dysfunction...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28928836/preoperative-serum-macrophage-activated-biomarkers-soluble-mannose-receptor-smr-and-soluble-haemoglobin-scavenger-receptor-scd163-as-novel-markers-for-the-diagnosis-and-prognosis-of-gastric-cancer
#8
Dongbing Ding, Yang Song, Yao Yao, Songbai Zhang
Soluble mannose receptor (sMR) and soluble haemoglobin scavenger receptor (sCD163) are macrophage activation markers which have previously been demonstrated to be increased in patients with inflammation, auto-immunity and malignancies. To investigate the clinical diagnostic and prognostic significance of preoperative serum sMR and sCD163, the present study investigated 143 gastric cancer (GC) patients, 66 subjects with benign gastric disease and 59 healthy controls, using an ELISA assay. Preoperative serum levels of sMR and sCD163 ranged from 0...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28928531/recovery-from-dietary-iron-deficiency-anaemia-in-rats-by-the-intake-of-microencapsulated-ferric-saccharate
#9
Elisabet Lázaro, Jonathan Santas, Magda Rafecas
This study examined the bioavailability of iron contained in microencapsulated ferric saccharate in a rat model of iron deficiency anaemia. Three groups of male Sprague-Dawley rats with induced iron deficiency anaemia were subsequently treated with a control Fe-deficient diet (2-6 mg Fe/Kg of diet) with or without the addition of 10 mg Fe/Kg of diet (in form of ferrous sulphate or microencapsulated ferric saccharate) for 2 weeks. The bioavailability of microencapsulated ferric saccharate was examined by measuring body weight gain, feed efficiency and reticulocyte parameters, and compared with the bioavailability of ferrous sulphate...
August 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28928176/controlling-nutritional-status-conut-score-as-a-predictor-of-all-cause-mortality-in-elderly-hypertensive-patients-a-prospective-follow-up-study
#10
Xiaonan Sun, Leiming Luo, Xiaoqian Zhao, Ping Ye
OBJECTIVES: The aim of this study was to elucidate the impact of nutritional status on survival per Controlling Nutritional Status (CONUT) score and Geriatric Nutritional Risk Index (GNRI) in patients with hypertension over 80 years of age. DESIGN: Prospective follow-up study. PARTICIPANTS: A total of 336 hypertensive patients over 80 years old were included in this study. OUTCOME MEASURES: All-cause deaths were recorded as Kaplan-Meier curves to evaluate the association between CONUT and all-cause mortality at follow-up...
September 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28927959/layer-specific-deformation-of-the-left-ventricle-in-uncomplicated-patients-with-type-2-diabetes-and-arterial-hypertension
#11
Marijana Tadic, Cesare Cuspidi, Vladan Vukomanovic, Sanja Ilic, Philippe Obert, Vesna Kocijancic, Vera Celic
BACKGROUND: Detailed analysis of layer-specific mechanical changes in patients with type 2 diabetes mellitus (DM) might improve insight into left ventricular (LV) remodelling and diabetic cardiomyopathy. AIM: We sought to investigate layer-specific LV deformation in patients with DM, with and without hypertension. METHODS: This cross-sectional study included 146 subjects (44 controls; 48 patients with DM; 54 patients with DM and hypertension) who underwent complete examination by two-dimensional echocardiography (2DE), including multilayer strain analysis...
September 15, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28927811/postinduction-apnoea-in-dogs-premedicated-with-acepromazine-or-dexmedetomidine-and-anaesthetized-with-alfaxalone-or-propofol
#12
Sarah E Bigby, Thierry Beths, Sébastien Bauquier, Jennifer E Carter
OBJECTIVE: To compare incidence and duration of postinduction apnoea in dogs after premedication with methadone and acepromazine (MA) or methadone and dexmedetomidine (MD) followed by induction with propofol (P) or alfaxalone (A). STUDY DESIGN: Prospective, randomized clinical trial. ANIMALS: A total of 32 American Society of Anesthesiologists class I dogs (15 females, 17 males), aged between 4 months and 4 years, weighing between 3 and 46 kg...
March 2, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28926088/treatments-for-priapism-in-boys-and-men-with-sickle-cell-disease
#13
REVIEW
Francis I Chinegwundoh, Sherie Smith, Kofi A Anie
BACKGROUND: Sickle cell disease comprises a group of genetic haemoglobin disorders. The predominant symptom associated with sickle cell disease is pain resulting from the occlusion of small blood vessels by abnormally 'sickle-shaped' red blood cells. There are other complications, including chronic organ damage and prolonged painful erection of the penis, known as priapism. Severity of sickle cell disease is variable, and treatment is usually symptomatic. Priapism affects up to half of all men with sickle cell disease, however, there is no consistency in treatment...
September 19, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28925898/gh-supplementation-effects-on-cardiovascular-risk-in-gh-deficient-adult-patients-a-systematic-review-and-meta-analysis
#14
Vito Angelo Giagulli, Marco Castellana, Raffaella Perrone, Edoardo Guastamacchia, Massimo Iacoviello, Vincenzo Triggiani
BACKGROUND AND OBJECTIVE: The current meta-analysis aims at evaluating whether the existing clinical evidence may ascertain the effects of growth hormone (GH) replacement therapy on cardiovascular risk, both in isolated GH deficiency (GHD) and in compensated panhypopituitarism including GH deficit. METHOD: Original articles published from 1991 to 2015 were searched on Medline (Pubmed). Among an overall number of 181 potentially suitable studies, 24 fulfilled the selection criteria and were included in the analysis...
September 19, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28924273/evaluation-of-random-plasma-glucose-for-assessment-of-glycaemic-control-in-type-2-diabetes-mellitus
#15
Qurratul Ain, Atif Latif, Syed Raza Jaffar, Aamir Ijaz
OBJECTIVE: To evaluate the accuracy of random plasma glucose in outpatients with type 2 diabetes mellitus for assessing glycaemic control. METHODS: This comparative, cross-sectional study was conducted at the chemical pathology department of PNS Shifa Hospital, Karachi, from August 2015 to March 2016, and comprised data of subjects with type 2 diabetes mellitus who reported for evaluation of glycaemic control in non-fasting state. All blood samples were analysed for random plasma glucose and glycated haemoglobin...
September 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28924269/effect-of-dietary-counselling-on-the-nutritional-status-of-end-stage-renal-disease-patients
#16
Bibi Hajira, Maryam Manzoor, Muhammad Samiullah, Rattan Kaur Chawla
OBJECTIVE: To investigate the effect of dietary counselling on the nutritional status of end-stage renal disease patients undergoing maintenance haemodialysis. METHODS: This study was conducted at the Institute of Kidney Diseases, Peshawar, Pakistan, from November to December 2015, and comprised patients of either gender with protein energy wasting. The nutritional status assessment was based on four categories, including biochemical indicators (haemoglobin, serum albumin and cholesterol), measure of body mass index, reduced body fatness, decreased muscle mass and low protein or energy intake...
September 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28923672/relationship-between-glycaemic-levels-and-arterial-stiffness-in-non-diabetic-adults
#17
Iván Cavero-Redondo, Vicente Martínez-Vizcaíno, Celia Álvarez-Bueno, José Ignacio Recio-Rodríguez, Manuel Ángel Gómez-Marcos, Luis García-Ortiz
OBJECTIVE: To examine, in a non-diabetic population, whether the association between arterial stiffness and glycaemic levels depends on the test used as a glycaemic indicator, fasting plasma glucose (FPG) or glycated haemoglobin A1c (HbA1c). PATIENT POPULATION AND METHODS: A cross-sectional analysis of a 220 non-diabetic subsample from the EVIDENT II study in which FPG, HbA1c and arterial stiffness-related parameters (pulse wave velocity, radial and central augmentation index, and central pulse pressure) were determined...
September 15, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28923465/continuous-glucose-monitoring-in-pregnant-women-with-type-1-diabetes-conceptt-a-multicentre-international-randomised-controlled-trial
#18
Denice S Feig, Lois E Donovan, Rosa Corcoy, Kellie E Murphy, Stephanie A Amiel, Katharine F Hunt, Elisabeth Asztalos, Jon F R Barrett, J Johanna Sanchez, Alberto de Leiva, Moshe Hod, Lois Jovanovic, Erin Keely, Ruth McManus, Eileen K Hutton, Claire L Meek, Zoe A Stewart, Tim Wysocki, Robert O'Brien, Katrina Ruedy, Craig Kollman, George Tomlinson, Helen R Murphy
BACKGROUND: Pregnant women with type 1 diabetes are a high-risk population who are recommended to strive for optimal glucose control, but neonatal outcomes attributed to maternal hyperglycaemia remain suboptimal. Our aim was to examine the effectiveness of continuous glucose monitoring (CGM) on maternal glucose control and obstetric and neonatal health outcomes. METHODS: In this multicentre, open-label, randomised controlled trial, we recruited women aged 18-40 years with type 1 diabetes for a minimum of 12 months who were receiving intensive insulin therapy...
September 14, 2017: Lancet
https://www.readbyqxmd.com/read/28922709/non-drainage-versus-drainage-in-tourniquet-free-knee-arthroplasty-a-prospective-trial
#19
Kai Zhou, Haoyang Wang, Jinglong Li, Duan Wang, Zongke Zhou, Fuxing Pei
BACKGROUND: It is still unknown whether drainage is necessary and non-drainage is safe and acceptable after tourniquet-free total knee arthroplasty (TKA). We aim to investigate whether non-drainage use is accepted in TKA that is performed without a tourniquet. METHODS: Clinical data of 80 adult patients who did or did not receive drainage in our centres from August 2015 to December 2015 were prospective investigated. RESULTS: The drainage group exhibited reduced hidden blood loss (47...
September 18, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28922684/-rbc-transfusion-triggers-in-orthopaedic-lower-limb-arthroplasty
#20
Dirk Holten, Peter Zaar, Stefan Kessler
Introduction We implemented a hospital-wide mandatory RBC transfusion trigger checklist based on the haemoglobin level transfusion thresholds recommended by the German federal physicians board. Transfusion triggers, transfusion rates and hospital LOS in orthopaedic lower limb arthroplasty were compared before and after implementation of the transfusion trigger checklist. The goal was to evaluate the effect of this single and easy-to-implement intervention on transfusion rates in orthopaedic lower limb arthroplasty...
September 18, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
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