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https://www.readbyqxmd.com/read/27903507/hydroxychloroquine-inhibits-proinflammatory-signalling-pathways-by-targeting-endosomal-nadph-oxidase
#1
Nadine Müller-Calleja, Davit Manukyan, Antje Canisius, Dennis Strand, Karl J Lackner
OBJECTIVES: Hydroxychloroquine (HCQ) has been used for decades to treat patients with rheumatic diseases, for example, systemic lupus erythematosus (SLE), rheumatoid arthritis or the antiphospholipid syndrome (APS). We hypothesise that HCQ might target endosomal NADPH oxidase (NOX), which is involved in the signal transduction of cytokines as well as antiphospholipid antibodies (aPL). METHODS: For in vitro experiments, monocytic cells were stimulated with tumour necrosis factor α (TNFα), interleukin-1β (IL-1β) or a human monoclonal aPL and the activity of NOX was determined by flow cytometry...
November 30, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27902889/the-complexities-of-doctor-patient-family-communication-in-an-asian-oncology-setting-concordance-and-discordance-among-patient-preferences-family-preferences-and-perceived-and-actual-communication
#2
Geok Ling Lee, Irene Teo, Ravindran Kanesvaran
This article reports on a pilot study that examined the complexities of doctor-patient-family communication in an oncology setting in Singapore. Twenty consultation visits were audio-recorded and a postconsultation questionnaire was administered to patients and their accompanying person (AP) to examine their communication preferences. Patients and APs rated physician expertise and message content as highly important; supportive elements of the communication were rated as less important. Patients preferred information concerning their condition, while APs preferred information regarding treatment options...
November 30, 2016: Health Communication
https://www.readbyqxmd.com/read/27902477/astragalus-polysaccharide-restores-autophagic-flux-and-improves-cardiomyocyte-function-in-doxorubicin-induced-cardiotoxicity
#3
Yuan Cao, Tao Shen, Xiuqing Huang, Yajun Lin, Beidong Chen, Jing Pang, Guoping Li, Que Wang, Sylvia Zohrabian, Chao Duan, Yang Ruan, Yong Man, Shu Wang, Jian Li
Doxorubicin (adriamycin), an anthracycline antibiotic, is commonly used to treat many types of solid and hematological malignancies. Unfortunately, clinical usage of doxorubicin is limited due to the associated acute and chronic cardiotoxicity. Previous studies demonstrated that Astragalus polysaccharide (APS), the extracts of Astragalus membranaceus, had strong anti-tumor activities and anti-inflammatory effects. However, whether APS could mitigate chemotherapy-induced cardiotoxicity is unclear thus far. We used a doxorubicin-induced neonatal rat cardiomyocyte injury model and a mouse heart failure model to explore the function of APS...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27897983/effects-of-polysaccharide-elicitors-from-endophytic-fusarium-oxysporum-fat9-on-the-growth-flavonoid-accumulation-and-antioxidant-property-of-fagopyrum-tataricum-sprout-cultures
#4
Lingyun Zhong, Bei Niu, Lin Tang, Fang Chen, Gang Zhao, Jianglin Zhao
The purpose of this study was to evaluate the effects of four different fungal polysaccharides, named water-extracted mycelia polysaccharide (WPS), sodium hydroxide-extracted mycelia polysaccharide (SPS), hydrochloric-extracted mycelia polysaccharide (APS), and exo-polysaccharide (EPS) obtained from the endophytic Fusarium oxysporum Fat9 on the sprout growth, flavonoid accumulation, and antioxidant capacity of tartary buckwheat. Without visible changes in the appearance of the sprouts, the exogenous polysaccharide elicitors strongly stimulated sprout growth and flavonoid production, and the stimulation effect was closely related with the polysaccharide (PS) species and its treatment dosage...
November 25, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27895596/reciprocal-modulation-of-ik1-ina-extends-excitability-in-cardiac-ventricular-cells
#5
Anthony Varghese
The inwardly rectifying potassium current (IK1) and the fast inward sodium current (INa) are reciprocally modulated in mammalian ventricular myocytes. An increase in the expression of channels responsible for one of these two currents results in a corresponding increase in expression of the other. These currents are critical in the propagation of action potentials (AP) during the normal functioning of the heart. This study identifies a physiological role for IK1-INa reciprocal modulation in ventricular fiber activation thresholds and conduction...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27893598/acceptability-and-effectiveness-of-assisted-human-immunodeficiency-virus-partner-services-in-mozambique-results-from-a-pilot-program-in-a-public-urban-clinic
#6
R Serene Myers, Caryl Feldacker, Freide Cesár, Zulmira Paredes, Gerito Augusto, Chadreque Muluana, Sinesia Citao, Catarina Mboa-Ferrao, Esmeralda Karajeanes, Matthew R Golden
BACKGROUND: Assisted partner services (APS) involves offering persons with human immunodeficiency virus (HIV) assistance notifying and testing their sex partners. Assisted partner services is rarely available in sub-Saharan Africa. We instituted a pilot APS program in Maputo, Mozambique. METHODS: Between June and September 2014, community health workers (CHWs) offered APS to persons with newly diagnosed HIV (index patients [IPs]). Community health workers interviewed IPs at baseline, 4 and 8 weeks...
November 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27891248/synchrotron-4-dimensional-imaging-of-two-phase-flow-through-porous-media
#7
F H Kim, D Penumadu, P Patel, X Xiao, E J Garboczi, S P Moylan, M A Donmez
Near real-time visualization of complex two-phase flow in a porous medium was demonstrated with dynamic 4-dimensional (4D) (3D + time) imaging at the 2-BM beam line of the Advanced Photon Source (APS) at Argonne National Laboratory. Advancing fluid fronts through tortuous flow paths and their interactions with sand grains were clearly captured, and formations of air bubbles and capillary bridges were visualized. The intense X-ray photon flux of the synchrotron facility made 4D imaging possible, capturing the dynamic evolution of both solid and fluid phases...
2016: MRS Adv
https://www.readbyqxmd.com/read/27889546/comparison-of-a-split-dose-bowel-preparation-with-2l-polyethylene-glycol-plus-ascorbic-acid-and-1l-polyethylene-glycol-plus-ascorbic-acid-and-bisacodyl-before-colonoscopy
#8
Seung Hun Kang, Yoon Tae Jeen, Jae Hyung Lee, In Kyung Yoo, Jae Min Lee, Seung Han Kim, Hyuk Soon Choi, Eun Sun Kim, Bora Keum, Hong Sik Lee, Hoon Jai Chun, Chang Duck Kim
BACKGROUND AND AIMS: Recently a low-volume polyethylene glycol containing ascorbic acid (PEG-Asc) formulation has proven as safe and effective as traditional 4L PEG solutions for colonoscopy preparation. However, currently available aqueous purgative formulations are poorly tolerated. The aim of this study was to compare a split-dose 2L PEG-Asc and a 1L PEG-Asc with bisacodyl (10 mg) formulation to determine the quality of bowel cleansing and patient tolerability. METHODS: A single-center, randomized, observer-blinded study was performed between May 2015 and September 2015...
November 23, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27888509/functional-properties-of-granule-cells-with-hilar-basal-dendrites-in-the-epileptic-dentate-gyrus
#9
Tony Kelly, Heinz Beck
OBJECTIVE: The maturation of adult-born granule cells and their functional integration into the network is thought to play a key role in the proper functioning of the dentate gyrus. In temporal lobe epilepsy, adult-born granule cells in the dentate gyrus develop abnormally and possess a hilar basal dendrite (HBD). Although morphological studies have shown that these HBDs have synapses, little is known about the functional properties of these HBDs or the intrinsic and network properties of the granule cells that possess these aberrant dendrites...
November 26, 2016: Epilepsia
https://www.readbyqxmd.com/read/27884691/aapt-diagnostic-criteria-for-chronic-cancer-pain-conditions
#10
REVIEW
Judith A Paice, Matt Mulvey, Michael Bennett, Patrick M Dougherty, John T Farrar, Patrick W Mantyh, Christine Miaskowski, Brian Schmidt, Thomas J Smith
: Chronic cancer pain is a serious complication of malignancy or its treatment. Currently, no comprehensive, universally accepted cancer pain classification system exists. Clarity in classification of common cancer pain syndromes would improve clinical assessment and management. Moreover, an evidence-based taxonomy would enhance cancer pain research efforts by providing consistent diagnostic criteria, ensuring comparability across clinical trials. As part of a collaborative effort between the Analgesic, Anesthetic, and Addiction Clinical Trial Translations Innovations Opportunities and Networks (ACTTION) and the American Pain Society (APS), the ACTTION-APS Pain Taxonomy (AAPT) initiative worked to develop the characteristics of an optimal diagnostic system...
November 21, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27882110/intermittent-fasting-is-neuroprotective-in-focal-cerebral-ischemia-by-minimizing-autophagic-flux-disturbance-and-inhibiting-apoptosis
#11
Ji Heun Jeong, Kwang Sik Yu, Dong Ho Bak, Je Hun Lee, Nam Seob Lee, Young Gil Jeong, Dong Kwan Kim, Jwa-Jin Kim, Seung-Yun Han
Previous studies have demonstrated that autophagy induced by caloric restriction (CR) is neuroprotective against cerebral ischemia. However, it has not been determined whether intermittent fasting (IF), a variation of CR, can exert autophagy-related neuroprotection against cerebral ischemia. Therefore, the neuroprotective effect of IF was evaluated over the course of two weeks in a rat model of focal cerebral ischemia, which was induced by middle cerebral artery occlusion and reperfusion (MCAO/R). Specifically, the role of autophagy modulation as a potential underlying mechanism for this phenomenon was investigated...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27882075/in-silico-evaluation-of-the-potential-antiarrhythmic-effect-of-epigallocatechin-3-gallate-on-cardiac-channelopathies
#12
Maroua Boukhabza, Jaouad El Hilaly, Nourdine Attiya, Ahmed El-Haidani, Younes Filali-Zegzouti, Driss Mazouzi, Mohamed-Yassine Amarouch
Ion channels are transmembrane proteins that allow the passage of ions according to the direction of their electrochemical gradients. Mutations in more than 30 genes encoding ion channels have been associated with an increasingly wide range of inherited cardiac arrhythmias. In this line, ion channels become one of the most important molecular targets for several classes of drugs, including antiarrhythmics. Nevertheless, antiarrhythmic drugs are usually accompanied by some serious side effects. Thus, developing new approaches could offer added values to prevent and treat the episodes of arrhythmia...
2016: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/27881784/low-somatic-sodium-conductance-enhances-action-potential-precision-in-time-coding-auditory-neurons
#13
Yang Yang, Bina Ramamurthy, Andreas Neef, Matthew A Xu-Friedman
: Auditory nerve fibers encode sounds in the precise timing of action potentials (APs), which is used for such computations as sound localization. Timing information is relayed through several cell types in the auditory brainstem that share an unusual property: their APs are not overshooting, suggesting that the cells have very low somatic sodium conductance (gNa). However, it is not clear how gNa influences temporal precision. We addressed this by comparing bushy cells (BCs) in the mouse cochlear nucleus with T-stellate cells (SCs), which do have normal overshooting APs...
November 23, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27881714/a-gpi-processing-phospholipase-a2-pgap6-modulates-nodal-signaling-in-embryos-by-shedding-cripto
#14
Gun-Hee Lee, Morihisa Fujita, Katsuyoshi Takaoka, Yoshiko Murakami, Yoshitaka Fujihara, Noriyuki Kanzawa, Kei-Ichi Murakami, Eriko Kajikawa, Yoko Takada, Kazunobu Saito, Masahito Ikawa, Hiroshi Hamada, Yusuke Maeda, Taroh Kinoshita
Glycosylphosphatidylinositol-anchored proteins (GPI-APs) can be shed from the cell membrane by GPI cleavage. In this study, we report a novel GPI-processing enzyme, termed post-glycosylphosphatidylinositol attachment to proteins 6 (PGAP6), which is a GPI-specific phospholipase A2 mainly localized at the cell surface. CRIPTO, a GPI-AP, which plays critical roles in early embryonic development by acting as a Nodal coreceptor, is a highly sensitive substrate of PGAP6, whereas CRYPTIC, a close homologue of CRIPTO, is not sensitive...
November 23, 2016: Journal of Cell Biology
https://www.readbyqxmd.com/read/27877047/antiallergic-effect-of-the-atomized-extract-of-rhizome-of-curcuma-longa-flowers-of-cordia-lutea-and-leaves-of-annona-muricata
#15
Jorge Arroyo-Acevedo, Cesar Franco-Quino, Eliberto Ruiz-Ramirez, Roberto Chávez-Asmat, Andrea Anampa-Guzmán, Ernesto Raéz-González, José Cabanillas-Coral
INTRODUCTION: Allergies are a problem that greatly affects the population, and hence the use of antiallergic medications is fairly widespread. However, these drugs have many adverse effects. The use of medicinal plants could be an option, but they need to be evaluated. OBJECTIVE: This study was designed to evaluate the antiallergic effect of the atomized extract of rhizome of Curcuma longa, flowers of Cordia lutea, and leaves of Annona muricata. MATERIALS AND METHODS: Twenty-four New Zealand white albino rabbits were randomized into 2 groups...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27874901/the-assembly-of-thiophene-based-bis-pyridyl-bis-amide-co-ii-coordination-polymers-and-their-polypyrrole-functionalized-hybrid-materials-for-boosting-their-photocatalytic-performances
#16
Xiu-Li Wang, Xiao-Mei Wu, Guo-Cheng Liu, Hong-Yan Lin, Xiang Wang
Herein, a series of multifunctional Co(II) coordination polymer (CP) materials, which were based on a new semi-rigid thiophene-containing bis-pyridyl-bis-amide N,N'-bis(pyridine-3-yl)thiophene-2,5-dicarboxamide (3-bptpa) ligand and different polycarboxylates, namely, [Co(3-bptpa)(1,3-BDC)]·2H2O (CP1), [Co(3-bptpa)(5-MIP)]·2H2O (CP2), [Co(3-bptpa)(1,3,5-HBTC)] (CP3), [Co(3-bptpa)(5-NIP)]·2H2O (CP4) and [Co(3-bptpa)(1,3-BDC)]·2H2O (CP5) (1,3-H2BDC = 1,3-benzenedicarboxylic acid, 5-H2MIP = 5-methylisophthalic acid, 1,3,5-H3BTC = 1,3,5-benzenetricarboxylic acid, 5-H2NIP = 5-nitroisophthalic acid) and their polypyrrole (PPy)-functionalized hybrid materials PPy/CPn (n = 1, 2, 3, 4, 5), have been prepared...
November 22, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27868072/the-role-of-tlr4-on-b-cell-activation-and-anti-%C3%AE-2gpi-antibody-production-in-the-antiphospholipid-syndrome
#17
REVIEW
Si Cheng, Haibo Wang, Hong Zhou
High titer of anti-β2-glycoprotein I antibodies (anti-β2GPI Ab) plays a pathogenic role in antiphospholipid syndrome (APS). Numerous studies have focused on the pathological mechanism in APS; however, little attention is paid to the immune mechanism of production of anti-β2GPI antibodies in APS. Our previous study demonstrated that Toll-like receptor 4 (TLR4) plays a vital role in the maturation of bone marrow-derived dendritic cells (BMDCs) from the mice immunized with human β2-glycoprotein I (β2GPI)...
2016: Journal of Immunology Research
https://www.readbyqxmd.com/read/27865435/-the-pulse-mass-index-as-a-predictor-of-cardiovascular-events-in-women-with-systemic-lupus-erythematosus
#18
Elsy Aidé García-Villegas, Horacio Márquez-González, Luis Felipe Flores-Suárez, Antonio Rafael Villa-Romero
BACKGROUND: Patients with systemic lupus erythematosus (SLE) have 3times the risk of death compared to the rest of the population, with cardiovascular events (CVD) being one of the main causes. Índices such as waist-height (W-Ht I), waist-hip (W-Hp I) and pulse-mass (PMI) predict CVD, though the behaviour is unknown in patients with SLE. The aim of this study was to determine the prognostic value of PMI in the development of CVD in premenopausal women with SLE. METHODOLOGY: Cohort study...
November 16, 2016: Medicina Clínica
https://www.readbyqxmd.com/read/27865053/neural-progenitor-cells-and-their-role-in-the-development-and-evolutionary-expansion-of-the-neocortex
#19
REVIEW
Takashi Namba, Wieland B Huttner
The evolutionary expansion of the mammalian brain, notably the neocortex, provides a platform for the higher cognitive abilities that characterize humans. Cortical expansion is accompanied by increased folding of the pial surface, which gives rise to a gyrencephalic (folded) rather than lissencephalic (unfolded) neocortex. This expansion reflects the prolonged and increased proliferation of neural stem and progenitor cells (NPCs). Distinct classes of NPCs can be distinguished based on either cell biological criteria (apical progenitors [APs], basal progenitors [BPs]) or lineage (primary progenitors and secondary progenitors)...
November 16, 2016: Wiley Interdisciplinary Reviews. Developmental Biology
https://www.readbyqxmd.com/read/27864337/connexin-mediated-signalling-in-non-sensory-cells-is-crucial-for-the-development-of-sensory-inner-hair-cells-in-the-mouse-cochlea
#20
Stuart L Johnson, Federico Ceriani, Oliver Houston, Roman Polishchuk, Elena Polishchuk, Giulia Crispino, Veronica Zorzi, Fabio Mammano, Walter Marcotti
: Mutations in the genes encoding for gap junction proteins connexin 26 (Cx26) and connexin 30 (Cx30) have been linked to syndromic and non-syndromic hearing loss in mice and humans. The release of ATP from connexin hemichannels in cochlear non-sensory cells has been proposed to be the main trigger for action potential (AP) activity in immature sensory inner hair cells (IHCs), which is crucial for the refinement of the developing auditory circuitry. Using connexin knockout mice, we show that IHCs fire spontaneous APs even in the absence of ATP-dependent intercellular Ca(2+) signalling in the non-sensory cells...
November 18, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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