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Induced hypothermia

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https://www.readbyqxmd.com/read/28069320/mild-induced-hypothermia-for-patients-with-severe-traumatic-brain-injury-after-decompressive-craniectomy
#1
Chunhai Tang, Yun Bao, Min Qi, Lizhi Zhou, Fan Liu, Jian Mao, Qingmei Lei, Songtao Qi, Binghui Qiu
PURPOSE: To evaluate the efficacy and safety of mild induced hypothermia for intracranial hypertension in patients with traumatic brain injury after decompressive craniectomy. METHODS: A total of 60 adults with intracranial pressure (ICP) of more than 20 mm Hg after decompressive craniectomy were randomly assigned to standard care (control group) or hypothermia (32°C-35°C) plus standard care. Then, ICP, cerebral perfusion pressure, Glasgow Outcome Scale score, and complications were assessed...
December 29, 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/28054002/data-on-pharmacological-applications-and-hypothermia-protection-against-in-vitro-oxygen-glucose-deprivation-related-neurodegeneration-of-adult-rat-ca1-region
#2
Pınar Öz, Hale Saybaşılı
In this data article, the level of chemical neuroprotection against oxygen-glucose-deprivation (OGD)-related neurodegeneration in CA1 was analyzed using the measurements on CA1 stratum pyramidale (CA1sp) width. Adult rat hippocampal slices were incubated in OGD medium for 60 min to create a model for severe ischemic conditions. Alternatively, control slices were incubated in artificial cerebrospinal fluid (ACSF) for 60 min. A study of OGD induced neurodegeneration and partial prevention by pharmacological agents reported; baclofen, memantine and l-carnitine effects were included...
February 2017: Data in Brief
https://www.readbyqxmd.com/read/28053227/a-hypothalamic-circuit-that-controls-body-temperature
#3
Zheng-Dong Zhao, Wen Z Yang, Cuicui Gao, Xin Fu, Wen Zhang, Qian Zhou, Wanpeng Chen, Xinyan Ni, Jun-Kai Lin, Juan Yang, Xiao-Hong Xu, Wei L Shen
The homeostatic control of body temperature is essential for survival in mammals and is known to be regulated in part by temperature-sensitive neurons in the hypothalamus. However, the specific neural pathways and corresponding neural populations have not been fully elucidated. To identify these pathways, we used cFos staining to identify neurons that are activated by a thermal challenge and found induced expression in subsets of neurons within the ventral part of the lateral preoptic nucleus (vLPO) and the dorsal part of the dorsomedial hypothalamus (DMD)...
January 4, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28031340/il-15-enables-septic-shock-by-maintaining-nk-cell-integrity-and-function
#4
Yin Guo, Liming Luan, Naeem K Patil, Jingbin Wang, Julia K Bohannon, Whitney Rabacal, Benjamin A Fensterheim, Antonio Hernandez, Edward R Sherwood
Interleukin 15 is essential for the development and differentiation of NK and memory CD8(+) (mCD8(+)) T cells. Our laboratory previously showed that NK and CD8(+) T lymphocytes facilitate the pathobiology of septic shock. However, factors that regulate NK and CD8(+) T lymphocyte functions during sepsis are not well characterized. We hypothesized that IL-15 promotes the pathogenesis of sepsis by maintaining NK and mCD8(+) T cell integrity. To test our hypothesis, the pathogenesis of sepsis was assessed in IL-15-deficient (IL-15 knockout, KO) mice...
December 28, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28010996/pharmacological-characterization-of-rat-vd-hemopressin-%C3%AE-an-%C3%AE-hemoglobin-derived-peptide-exhibiting-cannabinoid-agonist-like-effects-in-mice
#5
Ting Zheng, Ting Zhang, Run Zhang, Zi-Long Wang, Zheng-Lan Han, Ning Li, Xu-Hui Li, Meng-Na Zhang, Biao Xu, Xiong-Li Yang, Quan Fang, Rui Wang
Hemopressin and related peptides have shown to function as the endogenous ligands or the regulator of cannabinoid receptors. Moreover, hemopressin and its truncated peptides were also reported to produce a slight modulatory effect on opioid system. In the present work, based on the amino acid sequence analyses of hemoglobin subunit α, rat VD-hemopressin(α) [(r)VD-Hpα] was predicted as a cannabinoid peptide derived from rat α-hemoglobin. Furthermore, (r)VD-Hpα was synthesized and characterized in a series of in vitro and in vivo assays...
December 16, 2016: Neuropeptides
https://www.readbyqxmd.com/read/28006657/the-6-chromanol-derivate-sul-109-enables-prolonged-hypothermic-storage-of-adipose-tissue-derived-stem-cells
#6
Ghazaleh Hajmousa, Pieter Vogelaar, Linda A Brouwer, Adrianus C van der Graaf, Robert H Henning, Guido Krenning
Encouraging advances in cell therapy research with adipose derived stem cells (ASC) require an effective short-term preservation method that provides time for quality control and transport of cells from their manufacturing facility to their clinical destination. Hypothermic storage of cells in their specific growth media offers an alternative and simple preservation method to liquid nitrogen cryopreservation or commercial preservation fluids for short-term storage and transport. However, accumulation of cell damage during hypothermia may result in cell injury and death upon rewarming through the production of excess reactive oxygen species (ROS)...
March 2017: Biomaterials
https://www.readbyqxmd.com/read/28002714/hypothermia-for-neuroprotection-in-convulsive-status-epilepticus
#7
RANDOMIZED CONTROLLED TRIAL
Stephane Legriel, Virginie Lemiale, Maleka Schenck, Jonathan Chelly, Virginie Laurent, Fabrice Daviaud, Mohamed Srairi, Aicha Hamdi, Guillaume Geri, Thomas Rossignol, Julia Hilly-Ginoux, Julie Boisramé-Helms, Benjamin Louart, Isabelle Malissin, Nicolas Mongardon, Benjamin Planquette, Marina Thirion, Sybille Merceron, Emmanuel Canet, Fernando Pico, Yves-Roger Tran-Dinh, Jean-Pierre Bedos, Elie Azoulay, Matthieu Resche-Rigon, Alain Cariou
Background Convulsive status epilepticus often results in permanent neurologic impairment. We evaluated the effect of induced hypothermia on neurologic outcomes in patients with convulsive status epilepticus. Methods In a multicenter trial, we randomly assigned 270 critically ill patients with convulsive status epilepticus who were receiving mechanical ventilation to hypothermia (32 to 34°C for 24 hours) in addition to standard care or to standard care alone; 268 patients were included in the analysis. The primary outcome was a good functional outcome at 90 days, defined as a Glasgow Outcome Scale (GOS) score of 5 (range, 1 to 5, with 1 representing death and 5 representing no or minimal neurologic deficit)...
22, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27999623/personalized-approach-in-brain-protection-by-hypothermia-individual-changes-in-non-pathological-and-ischemia-related-glutamate-transport-in-brain-nerve-terminals
#8
Artem Pastukhov, Natalia Krisanova, Vitalii Maksymenko, Tatiana Borisova
BACKGROUND: Both deep and profound hypothermia are effectively applied in cardiac surgery of the aortic arch, when the reduction of cerebral circulation facilitates operations, and for the prevention of ischemic stroke consequences. Neurochemical discrimination of the effects of deep and profound hypothermia (27 and 17 °C, respectively) on non-pathological and pathological ischemia-related mechanisms of presynaptic glutamate transport with its potential contribution to predictive, preventive and personalized medicine (PPPM) was performed...
2016: EPMA Journal
https://www.readbyqxmd.com/read/27998781/tfp5-is-comparable-to-mild-hypothermia-in-improving-neurological-outcomes-in-early-stage-ischemic-stroke-of-adult-rats
#9
Ya-Bin Ji, Pei-Pei Zhuang, Zhong Ji, Kai-Bin Huang, Yong Gu, Yong-Ming Wu, Su-Yue Pan, Ya-Fang Hu
AIM: We compared the efficacy of a modified truncated 24-aa peptide (TFP5), derived from the cyclin-dependent kinase 5 (CDK5)-activating cofactor p35, with mild hypothermia (MH), and determined whether the efficacy of TFP5 is affected by MH. METHODS: Ischemic stroke was induced in adult male Sprague-Dawley rats for 2h. Immediately after initiating reperfusion, TFP5, MH, or the combination of the two were administrated. 48h after reperfusion, neurological outcomes were evaluated...
December 18, 2016: Neuroscience
https://www.readbyqxmd.com/read/27998282/does-therapeutic-hypothermia-during-extracorporeal-cardiopulmonary-resuscitation-preserve-cardiac-function
#10
Harald A Bergan, Per S Halvorsen, Helge Skulstad, Erik Fosse, Jan F Bugge
BACKGROUND: Extracorporeal cardiopulmonary resuscitation (E-CPR) is increasingly used as a rescue method in the management of cardiac arrest and provides the opportunity to rapidly induce therapeutic hypothermia. The survival after a cardiac arrest is related to post-arrest cardiac function, and the application of therapeutic hypothermia post-arrest is hypothesized to improve cardiac outcome. The present animal study compares normothermic and hypothermic E-CPR considering resuscitation success, post-arrest left ventricular function and magnitude of myocardial injury...
December 20, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27990123/brief-rewarming-blunts-hypothermia-induced-alterations-in-sensation-motor-drive-and-cognition
#11
Marius Brazaitis, Henrikas Paulauskas, Albertas Skurvydas, Henning Budde, Laura Daniuseviciute, Nerijus Eimantas
Background: It is well known that cold exposure experienced during occupational or recreational activities may adversely affect motor, cognitive performance, and health. Most research has used prolonged passive external rewarming modalities and focused on the direct effects on the kinetics of physiological and psychological responses in hypothermic subjects. However, the brief whole body rewarming effects on physiological and psychological responses in parallel with functional consequences on cognitive and neurophysiological functions have not been investigated...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27988510/in-the-era-of-therapeutic-hypothermia-how-well-do-studies-of-perinatal-neuroprotection-control-temperature
#12
Robert Galinsky, Justin M Dean, Christopher A Lear, Joanne O Davidson, Simerdeep Dhillon, Guido Wassink, Laura Bennet, Alistair J Gunn
In the era of therapeutic hypothermia, reliable preclinical studies are integral to successfully identify neuroprotective strategies to further improve outcomes of encephalopathy at term. We reviewed preclinical neuroprotection studies reported between January 2014 and June 2016 to assess the use of effective temperature monitoring and control. As a secondary measure, we examined whether studies addressed other methodological issues such as stage of brain development, sex differences, the timing of the treatment relative to the insult, and the histological and functional endpoints used after hypoxia-ischemia...
December 17, 2016: Developmental Neuroscience
https://www.readbyqxmd.com/read/27975140/profound-hypothermia-after-adenosine-kinase-inhibition-in-a1ar-deficient-mice-suggests-a-receptor-independent-effect-of-intracellular-adenosine
#13
Christoph Eisner, SooMi Kim, Alexandra Grill, Yan Qin, Marion Hoerl, Josephine Briggs, Hayo Castrop, Manfred Thiel, Jurgen Schnermann
Administration of the nucleoside adenosine has been shown to induce hypothermia in a number of species, an effect mediated predominantly by the adenosine 1 receptor (A1AR) subtype. The present experiments were performed to explore the possibility that the rise of intracellular adenosine levels expected to accompany adenosine administration may contribute to the hypothermic effect of adenosine independent of A1AR activation. Since phosphorylation of adenosine by adenosine kinase (ADK) is causal in the maintenance of low intracellular adenosine, we have examined the effect of ADK inhibition on core body temperature (CBT)...
December 14, 2016: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/27973471/peroxisome-proliferator-activated-receptor-%C3%AE-agonist-pioglitazone-reduces-the-development-of-necrotizing-enterocolitis-in-a-neonatal-preterm-rat-model
#14
Iuri Corsini, Simone Polvani, Mirko Tarocchi, Sara Tempesti, Giada Marroncini, Marta Generoso, Cecilia Bresci, Elena Gozzini, Tommaso Bianconi, Andrea Galli, Carlo Dani
BACKGROUND: Factors affecting innate immunity and acting as inflammatory regulators, such as the nuclear peroxisome proliferator-activated receptors (PPAR) could be crucial in the pathogenesis of necrotizing enterocolitis (NEC). We hypothesized that the PPARγ agonist pioglitazone (PIO) might be effective in preventing the development of NEC and/or reducing its severity. METHODS: We studied preterm rats in which NEC was induced using the hypoxia-hypothermia model...
December 14, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27966584/ebselen-preserves-tissue-engineered-cell-sheets-and-their-stem-cells-in-hypothermic-conditions
#15
Ryosuke Katori, Ryuhei Hayashi, Yuki Kobayashi, Eiji Kobayashi, Kohji Nishida
Clinical trials have been performed using autologous tissue-engineered epithelial cell sheets for corneal regenerative medicine. To improve stem cell-based therapy for convenient clinical practice, new techniques are required for preserving reconstructed tissues and their stem/progenitor cells until they are ready for use. In the present study, we screened potential preservative agents and developed a novel medium for preserving the cell sheets and their stem/progenitor cells; the effects were evaluated with a luciferase-based viability assay...
December 14, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27966094/therapeutic-hypothermia-for-birth-asphyxia-in-neonates
#16
REVIEW
Vikram Datta
India contributes to the highest neonatal mortality globally. Birth asphyxia is one of the leading causes of neonatal mortality in India. A large number of neonates who suffer from birth asphyxia progress to Hypoxic Ischemic Encephalopathy (HIE). The risk of a neonate progressing to severe form of HIE is many times higher in the low and middle income countries (LMICs) with ill developed health infrastructure. Till date LMICs have had a low institutional delivery rate, poor regionalization of care, lack of adequate transport facilities and ill equipped neonatal intensive care facilities...
December 14, 2016: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/27964981/aortic-root-surgery-with-circulatory-arrest-predictors-of-prolonged-postoperative-hospital-stay
#17
Ourania Preventza, Joseph S Coselli, Andrea Garcia, Shahab Akvan, Sarang Kashyap, Katherine H Simpson, Matt D Price, Kim I de la Cruz, Konstantinos Spiliotopoulos, Lorraine D Cornwell, Faisal G Bakaeen, Shuab Omer, Denton A Cooley
OBJECTIVE: Little is known about the outcomes of aortic root operations that involve inducing hypothermic circulatory arrest for relatively extensive proximal aortic surgery. We attempted to identify predictors of postoperative hospital length of stay (LOS) and factors that affect postoperative recovery. METHODS: During 2006-2014, 247 of 265 patients (93.2%) with disease extending into the aortic arch survived aortic root operations (206 elective, 41 urgent/emergent) in which hypothermic circulatory arrest with moderate hypothermia was used...
November 16, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27941300/reperfusion-damage%C3%A3-a-story-of-success-failure-and-hope
#18
Roberto Ferrari, Cristina Balla, Michele Malagù, Gabriele Guardigli, Giampaolo Morciano, Matteo Bertini, Simone Biscaglia, Gianluca Campo
Tissue salvage of severely ischemic myocardium requires timely reperfusion by thrombolysis, angioplasty, or bypass. However, recovery of left ventricular function is rare. It may be absent or, even worse, reperfusion can induce further damage. Laboratory studies have shown convincingly that reperfusion can increase injury over and above that attributable to the pre-existing ischemia, precipitating arrhythmias, suppressing the recovery of contractile function ("stunning") and possibly even causing cell death in potentially salvable ischemic tissue...
December 9, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27933367/antipsychotic-inductors-of-brain-hypothermia-and-torpor-like-states-perspectives-of-application
#19
REVIEW
Yury S Tarahovsky, Irina S Fadeeva, Natalia P Komelina, Maxim O Khrenov, Nadezhda M Zakharova
Hypothermia and hypometabolism (hypometabothermia) normally observed during natural hibernation and torpor, allow animals to protect their body and brain against the damaging effects of adverse environment. A similar state of hypothermia can be achieved under artificial conditions through physical cooling or pharmacological effects directed at suppression of metabolism and the processes of thermoregulation. In these conditions called torpor-like states, the mammalian ability to recover from stroke, heart attack, and traumatic injuries greatly increases...
January 2017: Psychopharmacology
https://www.readbyqxmd.com/read/27923323/mild-hypothermia-promotes-pericontusion-neuronal-sprouting-via-suppressing-suppressor-of-cytokine-signaling-3-expression-after-moderate-traumatic-brain-injury
#20
Cheng-Cheng Zhao, Chuan-Fang Wang, Wei-Ping Li, Yong Lin, Qi-Lin Tang, Jun-Feng Feng, Qing Mao, Guo-Yi Gao, Ji-Yao Jiang
Mild therapeutic hypothermia is a candidate for the treatment of traumatic brain injury (TBI). However, the role of mild hypothermia in neuronal sprouting after TBI remains obscure. We used a fluid percussion injury (FPI) model to assess the effect of mild hypothermia on pericontusion neuronal sprouting after TBI in rats. Male Sprague-Dawley rats underwent FPI or sham surgery, followed by mild hypothermia treatment (33°C) or normothermia treatment (37°C) for 3 h. All the rats were euthanized at 7 days after FPI...
January 13, 2017: Journal of Neurotrauma
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