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Induced hypothermia

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https://www.readbyqxmd.com/read/29327153/the-effect-of-therapeutic-mild-hypothermia-on-brain-microvascular-endothelial-cells-during-ischemia-reperfusion-injury
#1
Yao Chen, Lin Wang, Yun Zhang, Yaxiong Zhou, Wei Wei, Zhi Wan
BACKGROUND: To determine the cerebral protective effects of mild hypothermia (MH) on cerebral microcirculation. METHODS: We established ischemia-reperfusion (I/R) injury and MH treatment models with rat brain microvascular endothelial cells (RBMECs) in vitro and examined the apoptotic changes. The cultured RBMECs were randomly divided into the control group, I/R group, and MH group, which was further divided into two subgroups: intra-ischemia hypothermia (IIH) and post-ischemia hypothermia (PIH)...
January 11, 2018: Neurocritical Care
https://www.readbyqxmd.com/read/29325753/induced-hypothermia-in-patients-with-septic-shock-and-respiratory-failure-cass-a-randomised-controlled-open-label-trial
#2
Theis Skovsgaard Itenov, Maria Egede Johansen, Morten Bestle, Katrin Thormar, Lars Hein, Louise Gyldensted, Anne Lindhardt, Henrik Christensen, Stine Estrup, Henrik Planck Pedersen, Matthew Harmon, Uday Kant Soni, Silvia Perez-Protto, Nicolai Wesche, Ulrik Skram, John Asger Petersen, Thomas Mohr, Tina Waldau, Lone Musaeus Poulsen, Ditte Strange, Nicole P Juffermans, Daniel I Sessler, Else Tønnesen, Kirsten Møller, Dennis Karsten Kristensen, Alessandro Cozzi-Lepri, Jens D Lundgren, Jens-Ulrik Jensen
BACKGROUND: Animal models of serious infection suggest that 24 h of induced hypothermia improves circulatory and respiratory function and reduces mortality. We tested the hypothesis that a reduction of core temperature to 32-34°C attenuates organ dysfunction and reduces mortality in ventilator-dependent patients with septic shock. METHODS: In this randomised, controlled, open-label trial, we recruited patients from ten intensive care units (ICUs) in three countries in Europe and North America...
January 8, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29311303/pyruvate-induces-torpor-in-obese-mice
#3
Marion Soto, Lucie Orliaguet, Michelle L Reyzer, M Lisa Manier, Richard M Caprioli, C Ronald Kahn
Mice subjected to cold or caloric deprivation can reduce body temperature and metabolic rate and enter a state of torpor. Here we show that administration of pyruvate, an energy-rich metabolic intermediate, can induce torpor in mice with diet-induced or genetic obesity. This is associated with marked hypothermia, decreased activity, and decreased metabolic rate. The drop in body temperature correlates with the degree of obesity and is blunted by housing mice at thermoneutrality. Induction of torpor by pyruvate in obese mice relies on adenosine signaling and is accompanied by changes in brain levels of hexose bisphosphate and GABA as detected by mass spectroscopy-based imaging...
January 8, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29301706/an-experimental-study-and-finite-element-modeling-of-head-and-neck-cooling-for-brain-hypothermia
#4
Hui Li, Roland K Chen, Yong Tang, William Meurer, Albert J Shih
Reducing brain temperature by head and neck cooling is likely to be the protective treatment for humans when subjects to sudden cardiac arrest. This study develops the experimental validation model and finite element modeling (FEM) to study the head and neck cooling separately, which can induce therapeutic hypothermia focused on the brain. Anatomically accurate geometries based on CT images of the skull and carotid artery are utilized to find the 3D geometry for FEM to analyze the temperature distributions and 3D-printing to build the physical model for experiment...
January 2018: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29301219/liver-graft-susceptibility-during-static-cold-storage-and-dynamic-machine-perfusion-dcd-versus-fatty-livers
#5
Andrea Ferrigno, Laura G Di Pasqua, Clarissa Berardo, Veronica Siciliano, Vittoria Rizzo, Barbara Mannucci, Plinio Richelmi, Anna Cleta Croce, Mariapia Vairetti
We compared static preservation (cold storage, CS, 4 °C) with dynamic preservation (machine perfusion, MP, 20 °C) followed by reperfusion using marginal livers: a model of donation after cardiac death (DCD) livers and two models of fatty livers, the methionine-choline deficient (MCD) diet model, and obese Zucker (fa/fa) rats. CS injury in DCD livers was reversed by an oxygenated washout (OW): hepatic damage, bile flow, and the ATP/ADP ratio in the OW + CS group was comparable with the ratio obtained with MP...
December 31, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29300963/no-touch-aorta-robot-assisted-atrial-septal-defect-repair-via-two-ports
#6
Norihiko Ishikawa, Go Watanabe, Tatsuya Tarui
OBJECTIVES: Atrial septal defect (ASD) repairs have been successfully performed on arrested hearts with robotic assistance. The present study assessed the feasibility, safety, and efficacy of totally endoscopic cardiac surgery using a no-touch aorta technique for ASD via only 2 ports, and we named this procedure two-port robotic cardiac surgery (TROCS). METHODS: Between May 2014 and June 2016, 8 consecutive patients underwent TROCS for ASD using the da Vinci surgical system (Intuitive Surgical Inc...
January 2, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29288014/efficacy-of-different-cooling-technologies-for-therapeutic-temperature-management-a-prospective-intervention-study
#7
Petra Sonder, Gladys N Janssens, Albertus Beishuizen, Connie L Henry, Jon C Rittenberger, Clifton W Callaway, Cameron Dezfulian, Kees H Polderman
BACKGROUND: Mild therapeutic hypothermia (32-36 °C) is associated with improved outcomes in patients with brain injury after cardiac arrest (CA). Various devices are available to induce and maintain hypothermia, but few studies have compared the performance of these devices. We performed a prospective study to compare four frequently used cooling systems in inducing and maintaining hypothermia followed by controlled rewarming. METHODS: We performed a prospective multi-centered study in ten ICU's in three hospitals within the UPMC health system...
December 26, 2017: Resuscitation
https://www.readbyqxmd.com/read/29286319/cellular-and-molecular-mechanisms-underlying-non-pharmaceutical-ischemic-stroke-therapy-in-aged-subjects
#8
REVIEW
Raluca Elena Sandu, Danut Dumbrava, Roxana Surugiu, Daniela-Gabriela Glavan, Andrei Gresita, Eugen Bogdan Petcu
The incidence of ischemic stroke in humans increases exponentially above 70 years both in men and women. Comorbidities like diabetes, arterial hypertension or co-morbidity factors such as hypercholesterolemia, obesity and body fat distribution as well as fat-rich diet and physical inactivity are common in elderly persons and are associated with higher risk of stroke, increased mortality and disability. Obesity could represent a state of chronic inflammation that can be prevented to some extent by non-pharmaceutical interventions such as calorie restriction and hypothermia...
December 29, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29283978/review-hibernation-based-approaches-in-the-treatment-of-hemorrhagic-shock
#9
Andrea Wolf, Elizabeth R Lusczek, Gregory J Beilman
Hemorrhagic shock is the leading cause of preventable death after trauma. Hibernation-based treatment approaches have been of increasing interest for various biomedical applications. Due to apparent similarities in tissue perfusion and metabolic activity between severe blood loss and the hibernating state, hibernation-based approaches have also emerged for the treatment of hemorrhagic shock. Research has shown that hibernators are protected from shock-induced injury and inflammation. Utilizing the adaptive mechanisms that prevent injury in these animals may help alleviate the detrimental effects of hemorrhagic shock in non-hibernating species...
December 27, 2017: Shock
https://www.readbyqxmd.com/read/29278964/mild-hypothermia-protects-neurons-against-oxygen-glucose-deprivation-via-poly-adp-ribose-signaling
#10
Yubo Gao, Zhihua Wang, Weikun He, Wenjing Ma, Xinli Ni
OBJECTIVE: Hypothermia is a neuroprotective mechanism that has been validated for use in alleviating neonatal hypoxic-ischemic (HI) brain injury. Nevertheless, it is unclear whether poly (ADP-ribose) (PAR) signaling is involved in hypothermia-induced neuroprotection. In this study, we investigated whether mild hypothermia rescues oxygen glucose deprivation (OGD)-induced cell death by modifying PAR-relative protein expression, such as AIF, PARP-1, and PAR polymer, in primary-cultured hippocampal neurons...
December 26, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29275405/neonatal-systemic-inflammation-induces-inflammatory-reactions-and-brain-apoptosis-in-a-pathogen-specific-manner
#11
Mari Falck, Damjan Osredkar, Thomas Ragnar Wood, Elke Maes, Torun Flatebø, Hemmen Sabir, Marianne Thoresen
BACKGROUND: After neonatal asphyxia, therapeutic hypothermia (HT) is the only proven treatment option. Although established as a neuroprotective therapy, benefit from HT has been questioned when infection is a comorbidity to hypoxic-ischaemic (HI) brain injury. Gram-negative and gram-positive species activate the immune system through different pathogen recognition receptors and subsequent immunological systems. In rodent models, gram-negative (lipopolysaccharide [LPS]) and gram-positive (PAM3CSK4 [PAM]) inflammation similarly increase neuronal vulnerability to HI...
December 23, 2017: Neonatology
https://www.readbyqxmd.com/read/29262434/future-directions-for-hypothermia-following-severe-traumatic-brian-injury
#12
Annie W Chiu, Holly E Hinson
Traumatic brain injury (TBI) is a serious health care problem on both individual and public health levels. As a major cause of death and disability in the United States, it is associated with a significant economic and public health burden. Although the evidence to support the use of induced hypothermia on neurologic outcome after cardiac arrest is well established, its use in treating TBI remains controversial. Hypothermia has the potential to mitigate some of the destructive processes that occur as part of secondary brain injury after TBI...
December 2017: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29247448/itraq-based-quantitative-proteomics-reveals-the-new-evidence-base-for-traumatic-brain-injury-treated-with-targeted-temperature-management
#13
Shi-Xiang Cheng, Zhong-Wei Xu, Tai-Long Yi, Hong-Tao Sun, Cheng Yang, Ze-Qi Yu, Xiao-Sa Yang, Xiao-Han Jin, Yue Tu, Sai Zhang
This study aimed to investigate the effects of targeted temperature management (TTM) modulation on traumatic brain injury (TBI) and the involved mechanisms using quantitative proteomics technology. SH-SY5Y and HT-22 cells were subjected to moderate stretch injury using the cell injury controller (CIC), followed by incubation at TTM (mild hypothermia, 32°C), or normothermia (37°C). The real-time morphological changes, cell cycle phase distribution, death, and cell viability were evaluated. Moderate TBI was produced by the controlled cortical impactor (CCI), and the effects of TTM on the neurological damage, neurodegeneration, cerebrovascular histopathology, and behavioral outcome were determined in vivo...
December 15, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29247282/camellia-euphlebia-exerts-its-antidepressant-like-effect-via-modulation-of-the-hypothalamic-pituitary-adrenal-axis-and-brain-monoaminergic-systems
#14
Dongye He, Xuan Sai, Ning Wang, Xiaoyu Li, Lili Wang, Yongping Xu
Camellia euphlebia (family, Theaceae) is a Chinese folk medicine, known for its multiple pharmacological properties. The present study aimed to provide further insights into the therapeutic basis of C. euphlebia using several animal behavioral tests and physiological indexes. Tail suspension test, forced swimming test, open-field test, chronic unpredictable mild stress (CUMS), reversal of reserpine-induced hypothermia and palpebral ptosis, and 5-hydroxytryptophane-induced head-twitch response were used to evaluate the antidepressant effect of aqueous extract of Camellia euphlebia (AEC) on mice...
December 16, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29246395/cardiac-arrest-related-to-anaesthesia-in-williams-beuren-syndrome
#15
J Lucena Delgado, P Sanabria Carretero, P Durán la Fuente, A Gónzalez Rocafort, L Castro Parga, F Reinoso Barbero
Williams-Beuren syndrome is the clinical manifestation of a congenital genetic disorder in the elastin gene, among others. There is a history of cardiac arrest refractory to resuscitation manoeuvres in anaesthesia. The incidence of myocardial ischaemia is high during anaesthetic induction, but there are patients who do not have this condition yet also have had very serious cardiac events, and issues that are still to be resolved. Case descriptions will enable the common pathophysiological factors to be defined, and decrease morbidity and mortality...
December 12, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/29232696/effect-of-temperature-on-fatty-acid-metabolism-in-skeletal-muscle-mitochondria-of-untrained-and-endurance-trained-rats
#16
Jerzy A Zoladz, Agnieszka Koziel, Izabela Broniarek, Andrzej M Woyda-Ploszczyca, Karolina Ogrodna, Joanna Majerczak, Jan Celichowski, Zbigniew Szkutnik, Wieslawa Jarmuszkiewicz
We studied the effects of various assay temperatures, representing hypothermia (25°C), normothermia (35°C), and hyperthermia (42°C), on the oxidation of lipid-derived fuels in rat skeletal muscle mitochondria of untrained and endurance-trained rats. Adult 4-month-old male Wistar rats were assigned to a training group (rats trained on a treadmill for 8 weeks) or a sedentary control group. In skeletal muscle mitochondria of both control and trained rats, an increase in the assay temperature from 25°C to 42°C was accompanied by a consistent increase in the oxidation of palmitoylcarnitine and glycerol-3-phosphate...
2017: PloS One
https://www.readbyqxmd.com/read/29228720/gastric-myoelectric-activity-during-cisplatin-induced-acute-and-delayed-emesis-reveals-a-temporal-impairment-of-slow-waves-in-ferrets-effects-not-reversed-by-the-glp-1-receptor-antagonist-exendin-9-39
#17
Zengbing Lu, Man P Ngan, Ge Lin, David T W Yew, Xiaodan Fan, Paul L R Andrews, John A Rudd
Preclinical studies show that the glucagon-like peptide-1 (GLP-1) receptor antagonist, exendin (9-39), can reduce acute emesis induced by cisplatin. In the present study, we investigate the effect of exendin (9-39) (100 nmol/24 h, i.c.v), on cisplatin (5 mg/kg, i.p.)-induced acute and delayed emesis and changes indicative of 'nausea' in ferrets. Cisplatin induced 37.2 ± 2.3 and 59.0 ± 7.7 retches + vomits during the 0-24 (acute) and 24-72 h (delayed) periods, respectively. Cisplatin also increased (P<0...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29226111/comparison-of-electronic-learning-versus-lecture-based-learning-in-improving-emergency-medicine-residents-knowledge-about-mild-induced-hypothermia-after-cardiac-arrest
#18
Maryam Soleimanpour, Farzad Rahmani, Mehrad Naghizadeh Golzari, Alireza Ala, Hamid Reza Morteza Bagi, Robab Mehdizadeh Esfanjani, Hassan Soleimanpour
Background: The process of medical education depends on several issues such as training materials, students, professors, educational fields, and the applied technologies. The current study aimed at comparing the impacts of e-learning and lecture-based learning of mild induced hypothermia (MIH) after cardiac arrest on the increase of knowledge among emergency medicine residents. Methods: In a pre- and post-intervention study, MIH after cardiac arrest was taught to 44 emergency medicine residents...
August 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/29223591/mild-hypothermia-protects-hippocampal-neurons-from-oxygen-glucose-deprivation-injury-through-inhibiting-caspase-3-activation
#19
Tianen Zhou, Hui Lin, Longyuan Jiang, Tao Yu, Chaotao Zeng, Juanhua Liu, Zhengfei Yang
Mild hypothermia (MH) is thought to be one of the most effective therapeutic methods to treat hypoxic-ischemic encephalopathy (HIE) after cardiac arrest (CA). However, its precise mechanisms remain unclear. In this research, hippocampal neurons were cultured and treated with mild hypothermia and Ac-DEVD-CHO after oxygen-glucose deprivation (OGD). The activity of caspase-3 was detected, in order to find the precise concentration of Ac-DEVD-CHO with the same protective role in OGD injury as MH treatment. Western blot and immunofluorescence staining were conducted to analyze the effects of MH and Ac-DEVD-CHO on the expressions of caspase-3, caspase-8, and PARP...
December 6, 2017: Cryobiology
https://www.readbyqxmd.com/read/29220423/tpeak-tend-interval-during-therapeutic-hypothermia-can-predict-upcoming-ventricular-fibrillation-in-subjects-with-aborted-arrhythmic-sudden-cardiac-death-3-years-follow-up-results
#20
Namsik Yoon, Seo Hong, Aaron Glass, Sung Soo Kim, Min Chul Kim, Jae Yeong Cho, Ki Hong Lee, Doo Sun Sim, Hyun Ju Yoon, Kye Hun Kim, Young Joon Hong, Hyung Wook Park, Ju Han Kim, Youngkeun Ahn, Myung Jeong, Jong Chun Park, Jeong Gwan Cho
Aims: Prolonged Tpeak-Tend interval has been shown to be markers of arrhythmogenesis in various cardiac disorders. However, its dynamicity is one of the obstacles to predict fatal ventricular arrhythmia. This study investigated whether Tpeak-Tend interval during therapeutic hypothermia (TH) is associated with ventricular fibrillation (VF) inducibility and clinical arrhythmia in subjects with aborted arrhythmic sudden cardiac death (SCD). Methods and results: The study group included 31 patients (24 males, age 39...
December 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
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