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Induced hypothermia

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https://www.readbyqxmd.com/read/28210523/complete-recovery-from-cardiac-arrest-caused-by-risperidone-induced-hypothermia
#1
Takahiko Nagamine
Hypothermia is a rare adverse effect of risperidone and is associated with ventricular arrhythmias, which may lead to intensive care unit admission and sometimes death. We describe a patient with schizophrenia who was taking risperidone and who, after falling into a hypothermic state, suffered cardiac arrest. Observations of the case and a brief literature review are provided.
November 2016: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/28208012/hypothermia-inhibits-endothelium-independent-vascular-contractility-via-rho-kinase-inhibition
#2
Yoon Hee Chung, Keon Woong Oh, Sung Tae Kim, Eon Sub Park, Hyun Dong Je, Hyuk-Jun Yoon, Uy Dong Sohn, Ji Hoon Jeong, Hyen-Oh La
The present study was undertaken to investigate the influence of hypothermia on endothelium-independent vascular smooth muscle contractility and to determine the mechanism underlying the relaxation. Denuded aortic rings from male rats were used and isometric contractions were recorded and combined with molecular experiments. Hypothermia significantly inhibited fluoride-, thromboxane A₂-, phenylephrine-, and phorbol ester-induced vascular contractions regardless of endothelial nitric oxide synthesis, suggesting that another pathway had a direct effect on vascular smooth muscle...
February 17, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28202293/therapeutic-hypothermia-attenuates-brain-edema-in-a-pig-model-of-cardiac-arrest-possible-role-of-the-angiopoietin-tie-2-system
#3
Jiebin Li, ChunSheng Li, Wei Yuan, JunYuan Wu, Jie Li, ZhenHua Li, YongZhen Zhao
OBJECTIVE: This study aimed to clarify whether therapeutic hypothermia protects against cerebral edema following cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) in a porcine model via regulating the angiopoietin-Tie-2 ligand-receptor system. METHODS: Male pigs were randomized into the therapeutic hypothermia group, the normothermia group or the sham control group. CA was induced in pigs by untreated ventricular fibrillation for 8min. Brain edema was determined by measuring the cerebral cortical water content at 24h after the return of spontaneous circulation (ROSC)...
February 6, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28196356/therapeutic-hypothermia-provides-variable-protection-against-behavioral-deficits-after-neonatal-hypoxia-ischemia-a-potential-role-for-brain-derived-neurotrophic-factor
#4
Johana Diaz, Suleiman Abiola, Nancy Kim, Oliver Avaritt, Debra Flock, Jenny Yu, Frances J Northington, Raul Chavez-Valdez
BACKGROUND: Despite treatment with therapeutic hypothermia (TH), infants who survive hypoxic ischemic (HI) encephalopathy (HIE) have persistent neurological abnormalities at school age. Protection by TH against HI brain injury is variable in both humans and animal models. Our current preclinical model of hypoxia-ischemia (HI) and TH displays this variability of outcomes in neuropathological and neuroimaging end points with some sexual dimorphism. The detailed behavioral phenotype of this model is unknown...
February 15, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28194850/cannabidiol-reduces-ethanol-consumption-motivation-and-relapse-in-mice
#5
Adrián Viudez-Martínez, María S García-Gutiérrez, Carmen María Navarrón, María Isabel Morales-Calero, Francisco Navarrete, Ana Isabel Torres-Suárez, Jorge Manzanares
This study evaluated the effects of cannabidiol (CBD) on ethanol reinforcement, motivation and relapse in C57BL/6 J mice. The effects of CBD (60 mg/kg, i.p.) on blood ethanol concentration, hypothermia and handling-induced convulsions associated to acute ethanol administration were evaluated. The two-bottle choice paradigm was performed to assess the effects of CBD (30, 60 and 120 mg/kg/day, i.p.) on ethanol intake and preference. In addition, an oral ethanol self-administration experiment was carried out to evaluate the effects of CBD [a single s...
February 13, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28183461/management-of-no-reflow-phenomenon-in-the-catheterization-laboratory
#6
REVIEW
Shereif H Rezkalla, Rachel V Stankowski, Jennifer Hanna, Robert A Kloner
At the conclusion of a primary percutaneous coronary intervention for ST-segment elevation myocardial infarction, and after the cardiologist makes certain that there is no residual stenosis following stenting, assessment of coronary flow becomes the top priority. The presence of no-reflow is a serious prognostic sign. No-reflow can result in poor healing of the infarct and adverse left ventricular remodeling, increasing the risk for major adverse cardiac events, including congestive heart failure and death...
February 13, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28178853/clinical-vagus-nerve-stimulation-paradigms-induce-pronounced-brain-and-body-hypothermia-in-rats
#7
Lars Emil Larsen, Wouter Van Lysebettens, Charlotte Germonpré, Sofie Carrette, Sofie Daelemans, Mathieu Sprengers, Lisa Thyrion, Wytse Jan Wadman, Evelien Carrette, Jean Delbeke, Paul Boon, Kristl Vonck, Robrecht Raedt
Vagus nerve stimulation (VNS) is a widely used neuromodulation technique that is currently used or being investigated as therapy for a wide array of human diseases such as epilepsy, depression, Alzheimer's disease, tinnitus, inflammatory diseases, pain, heart failure and many others. Here, we report a pronounced decrease in brain and core temperature during VNS in freely moving rats. Two hours of rapid cycle VNS (7s on/18s off) decreased brain temperature by around [Formula: see text]C, while standard cycle VNS (30[Formula: see text]s on/300[Formula: see text]s off) was associated with a decrease of around [Formula: see text]C...
December 22, 2016: International Journal of Neural Systems
https://www.readbyqxmd.com/read/28177663/hypothermia-induced-by-inhibition-of-fatty-acid-metabolism-in-anesthetized-rats-contributions-of-the-forebrain-and-vagal-afferents
#8
T Osaka
2-Mercaptoacetate (MA) is an antimetabolic drug that inhibits the utilization of fatty acids as an energy source. The intravenous injection of MA (1.2 mmol kg-1) elicited an increase in tail skin temperature and a decrease in body core temperature in urethane-chloralose-anesthetized, neuromuscularly blocked, artificially ventilated rats, though administration of the same amount of NaCl did not. The respiratory exchange ratio was significantly higher after administration of MA than that after the saline treatment...
January 29, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28160299/sedative-and-motor-incoordination-effects-of-ethanol-in-mice-lacking-cd14-tlr2-tlr4-or-myd88
#9
Yuri A Blednov, Mendy Black, Jillian M Benavidez, Adriana Da Costa, Jody Mayfield, R Adron Harris
BACKGROUND: In our companion article, we examined the role of MyD88-dependent signaling in ethanol (EtOH) consumption in mice lacking key components of this inflammatory pathway and observed differential effects on drinking. Here, we studied the role of these same signaling components in the acute sedative, intoxicating, and physiological effects of EtOH. Toll-like receptor 4 (TLR4) has been reported to strongly reduce the duration of EtOH-induced sedation, although most studies do not support its direct involvement in EtOH consumption...
February 3, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28157590/delivery-of-nicotine-aerosol-to-mice-via-a-modified-electronic-cigarette-device
#10
Timothy W Lefever, Youn O K Lee, Alexander L Kovach, Melanie A R Silinski, Julie A Marusich, Brian F Thomas, Jenny L Wiley
BACKGROUND: Although both men and women use e-cigarettes, most preclinical nicotine research has focused on its effects in male rodents following injection. The goals of the present study were to develop an effective e-cigarette nicotine delivery system, to compare results to those obtained after subcutaneous (s.c.) injection, and to examine sex differences in the model. METHODS: Hypothermia and locomotor suppression were assessed following aerosol exposure or s...
January 18, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28145603/effect-of-delayed-digital-hypothermia-on-lamellar-inflammatory-signaling-in-the-oligofructose-laminitis-model
#11
K Dern, M Watts, B Werle, A van Eps, C Pollitt, J Belknap
BACKGROUND: In the oligofructose (OF) model of sepsis-related laminitis (SRL), digital hypothermia ("cryotherapy") initiated before the onset of clinical signs is reported not only to limit lamellar injury, but also to cause marked inhibition of lamellar inflammatory signaling. HYPOTHESIS/OBJECTIVES: Because hypothermia also has been reported to be protective when not initiated until the onset of lameness in the OF model of SRL, we hypothesized that the lamellar protection conferred by hypothermia is caused by local lamellar inhibition of inflammatory signaling as described when hypothermia was initiated earlier in the disease process...
February 1, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28140659/protective-effect-of-mild-induced-hypothermia-against-moderate-traumatic-brain-injury-in-rats-involved-in-necroptotic-and-apoptotic-pathways
#12
Hai-Bo Zhang, Shi-Xiang Cheng, Yue Tu, Sai Zhang, Shi-Ke Hou, Zhen Yang
AIM: To investigate the protective effect of hypothermia (HT) on brain injury in moderate traumatic brain injury (TBI) rat models and the potential mechanisms, especially the involvement of RIPK1 in apoptosis and necroptosis. METHODS: Adult Sprague-Dawley rats were randomized to four groups: sham+normothermia (sham+NT), sham+hypothermia (sham+HT), moderate TBI+normothermia (TBI+NT) and moderate TBI+hypothermia (TBI+HT). The sham+HT and TBI+HT groups were submitted to 32°C for 6 hours...
January 31, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28139962/intra-amniotic-administration-of-lipopolysaccharide-induces-spontaneous-preterm-labor-and-birth
#13
Nardhy Gomez-Lopez, Roberto Romero, Marcia Arenas-Hernandez, Bogdan Panaitescu, Valeria Garcia-Flores, Tara N Mial, Aashna Sahi, Sonia S Hassan
OBJECTIVE: Intra-amniotic infection is associated with spontaneous preterm labor. In most cases, the infection is subclinical and bacteria are detected in the amniotic cavity rather than in the chorioamniotic membranes. The aims of this study were to determine whether the intra-amniotic injection of a microbial product, lipopolysaccharide (LPS), could induce preterm labor/birth, and to compare this model to two established models of LPS-induced preterm labor/birth. METHODS: Pregnant B6 mice received an intra-amniotic, intra-uterine, or intra-peritoneal injection of LPS (100 ng/amniotic sac, 15μg/25μL, and 15μg/200μL respectively) or PBS (control)...
January 31, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28137611/analgesic-effect-of-dimethyl-trisulfide-in-mice-is-mediated-by-trpa1-and-sst4-receptors
#14
Gábor Pozsgai, Maja Payrits, Éva Sághy, Réka Sebestyén-Bátai, Elise Steen, Éva Szőke, Zoltán Sándor, Margit Solymár, András Garami, Péter Orvos, László Tálosi, Zsuzsanna Helyes, Erika Pintér
TRPA1 receptors are calcium-permeable ligand-gated channels expressed in primary sensory neurons and involved in inflammation and pain. Suggested mechanism of analgesic effect mediated by TRPA1 activation is the release of somatostatin (SOM) and its action on sst4 receptors. TRPA1 can be activated by polysulfides. In the present study analgesic effect of TRPA1 activation on primary sensory neurons by dialkyl polysulfide compound dimethyl trisulfide (DMTS) presumably leading to SOM release was investigated. Opening of TRPA1 by DMTS in CHO cells was examined by patch-clamp and fluorescent Ca(2+) detection...
January 27, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28134320/rna-binding-protein-rbm3-prevents-no-induced-apoptosis-in-human-neuroblastoma-cells-by-modulating-p38-signaling-and-mir-143
#15
Hai-Jie Yang, Fei Ju, Xin-Xin Guo, Shuang-Ping Ma, Lei Wang, Bin-Feng Cheng, Rui-Juan Zhuang, Bin-Bin Zhang, Xiang Shi, Zhi-Wei Feng, Mian Wang
Nitric oxide (NO)-induced apoptosis in neurons is an important cause of neurodegenerative disease in humans. The cold-inducible protein RBM3 mediates the protective effects of cooling on apoptosis induced by various insults. However, whether RBM3 protects neural cells from NO-induced apoptosis is unclear. This study aimed to investigate the neuroprotective effect of RBM3 on NO-induced apoptosis in human SH-SY5Y neuroblastoma cells. Firstly, we demonstrated that mild hypothermia (32 °C) induces RBM3 expression and confers a potent neuroprotective effect on NO-induced apoptosis, which was substantially diminished when RBM3 was silenced by siRNA...
January 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28130679/in-vivo-investigation-of-ear-canal-pulse-oximetry-during-hypothermia
#16
K Budidha, P A Kyriacou
Pulse oximeters rely on the technique of photoplethysmography (PPG) to estimate arterial oxygen saturation (SpO[Formula: see text]). In conditions of poor peripheral perfusion such as hypotension, hypothermia, and vasoconstriction, the PPG signals detected are often weak and noisy, or in some cases unobtainable. Hence, pulse oximeters produce erroneous SpO[Formula: see text] readings in these circumstances. The problem arises as most commercial pulse oximeter probes are designed to be attached to peripheral sites such as the finger or toe, which are easily affected by vasoconstriction...
January 27, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28118390/anesthesia-induced-hypothermia-attenuates-early-phase-blood-brain-barrier-disruption-but-not-infarct-volume-following-cerebral-ischemia
#17
Yu-Cheng Liu, Yu-Da Lee, Hwai-Lee Wang, Kate Hsiurong Liao, Kuen-Bao Chen, Kin-Shing Poon, Yu-Ling Pan, Ted Weita Lai
Blood-brain barrier (BBB) disruption is thought to facilitate the development of cerebral infarction after a stroke. In a typical stroke model (such as the one used in this study), the early phase of BBB disruption reaches a peak 6 h post-ischemia and largely recovers after 8-24 h, whereas the late phase of BBB disruption begins 48-58 h post-ischemia. Because cerebral infarct develops within 24 h after the onset of ischemia, and several therapeutic agents have been shown to reduce the infarct volume when administered at 6 h post-ischemia, we hypothesized that attenuating BBB disruption at its peak (6 h post-ischemia) can also decrease the infarct volume measured at 24 h...
2017: PloS One
https://www.readbyqxmd.com/read/28093198/mild-hypothermia-pretreatment-protects-hepatocytes-against-ischemia-reperfusion-injury-via-down-regulating-mir-122-and-igf-1r-akt-pathway
#18
Qi Xiao, Qi-Fa Ye, Wei Wang, Bi-Qi Fu, Zhi-Ping Xia, Zhong-Zhong Liu, Xing-Jian Zhang, Yan-Feng Wang
BACKGROUND: Mild hypothermia has been well known as an effective way to reduce ischemia reperfusion injury (IRI), while the mechanisms are still unclear. More and more evidences have indicated that miRNAs should been involved in the regulation of IRI and expecially some miRNAs have shown temp-responsiveness for temperature variation. Therefore, the role of miR-122 in mild hypothermia pretreatment after IRI was investigated. METHODS: We established a LO2 cell anoxia-reoxygenation injury model to simulate liver IRI...
January 13, 2017: Cryobiology
https://www.readbyqxmd.com/read/28069320/mild-induced-hypothermia-for-patients-with-severe-traumatic-brain-injury-after-decompressive-craniectomy
#19
Chunhai Tang, Yun Bao, Min Qi, Lizhi Zhou, Fan Liu, Jian Mao, Qingmei Lei, Songtao Qi, Binghui Qiu
PURPOSE: To evaluate the efficacy and safety of mild induced hypothermia for intracranial hypertension in patients with traumatic brain injury after decompressive craniectomy. METHODS: A total of 60 adults with intracranial pressure (ICP) of more than 20 mm Hg after decompressive craniectomy were randomly assigned to standard care (control group) or hypothermia (32°C-35°C) plus standard care. Then, ICP, cerebral perfusion pressure, Glasgow Outcome Scale score, and complications were assessed...
December 29, 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/28054002/data-on-pharmacological-applications-and-hypothermia-protection-against-in-vitro-oxygen-glucose-deprivation-related-neurodegeneration-of-adult-rat-ca1-region
#20
Pınar Öz, Hale Saybaşılı
In this data article, the level of chemical neuroprotection against oxygen-glucose-deprivation (OGD)-related neurodegeneration in CA1 was analyzed using the measurements on CA1 stratum pyramidale (CA1sp) width. Adult rat hippocampal slices were incubated in OGD medium for 60 min to create a model for severe ischemic conditions. Alternatively, control slices were incubated in artificial cerebrospinal fluid (ACSF) for 60 min. A study of OGD induced neurodegeneration and partial prevention by pharmacological agents reported; baclofen, memantine and l-carnitine effects were included...
February 2017: Data in Brief
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