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https://www.readbyqxmd.com/read/29232679/clinicopathological-and-prognostic-features-of-surgical-management-in-duodenal-gastrointestinal-stromal-tumors
#1
Hong Peng Shi, Min Lu Huang, Zhen Qiang Wang, Ya Nan Zheng, Zheng Lun Zhu, Birendra Kumar Sah, Wen Tao Liu, Min Yan, Zheng Gang Zhu, Chen Li
BACKGROUND AND OBJECTIVES: The rarity of duodenal gastrointestinal stromal tumors (DGIST) led to only limited data being available on their management and prognosis. We retrospectively analyzed the clinicopathological features, surgical treatments, adjuvant therapy, and prognosis of DGIST. METHODS: Sixty-one patients were identified at diagnosis of primary DGIST from February 2005 to December 2015. One hundred twenty six patients with small intestinal gastrointestinal stromal tutors (GIST) were selected as control groups...
December 12, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/29232600/a-retrospective-review-of-phyllodes-tumours-of-the-breast-a-single-institution-experience
#2
Vithusha Ganesh, Leah Drost, Justin Lee, Bo Angela Wan, Liying Zhang, Eileen Rakovitch, Danny Vesprini, Elzbieta Slodkowska, K Liang Zeng, Philomena Sousa, Caitlin Yee, Henry Lam, Edward Chow
BACKGROUND: Phyllodes tumours are rare and histologically diverse, posing challenges in prognosis and treatment. Due to their rarity, they have seldom been studied. PURPOSE: The purpose was to investigate clinical practices in the management of phyllodes tumours, as well as patient outcomes to contribute to the limited body of knowledge surrounding these tumours. METHODS: A retrospective review was conducted on all patients with phyllodes tumours at a single institution...
December 9, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29232349/management-of-intussusception-in-the-pediatric-emergency-department-risk-factors-for-recurrence
#3
Andrea Vo, Terry L Levin, Benjamin Taragin, Hnin Khine
BACKGROUND: The standard treatment for intussusception is air reduction enema (ARE) with inpatient observation for 24 to 48 hours to monitor for recurrence. More recent but limited observations suggest that patients who have undergone successful ARE can safely be discharged after 4 to 6 hours of observation. Our primary objective was to identify risk factors associated with early recurrence. Our secondary objectives included validating risk criteria from prior studies and identifying risk factors for ARE failures...
December 11, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29232107/2d-material-based-nanofibrous-membrane-for-photothermal-cancer-therapy
#4
Jundong Shao, Hanhan Xie, Huaiyu Wang, Wenhua Zhou, Qian Luo, Xue-Feng Yu, Paul K Chu
One of the clinical challenges facing photothermal cancer therapy is health risks imposed by the photothermal nanoagents in vivo. Herein, a photothermal therapy (PTT) platform composed of 2D material-based nanofibrous membrane as the agent to deliver thermal energy to tumors under near-infrared (NIR) light irradiation is described. The photothermal membrane, which is fabricated by electrospinning poly (L-lactic acid) (PLLA) nanofibrous membrane loaded with bismuth selenide (Bi2Se3) nanoplates, exhibits very high photothermal conversion efficiency and long-term stability...
December 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29231991/combination-of-tnm-staging-and-pathway-based-risk-score-models-in-patients-with-gastric-cancer
#5
Yang-Yang Zhou, Yan-Ting Kang, Chao Chen, Fan-Fan Xu, Hao-Nan Wang, Rong Jin
Due to the complexity and heterogeneity of gastric cancer (GC) in individual patient, current staging system is inadequate for predicting outcome of GC. Comprehensive computational and bioinformatics approach may triumph for the prediction. In this study, GC patients were devided according stage and treatment: curative surgery plus chemoradiotherapy in stage II, curative surgery plus chemoradiotherapy in stage III and IV, unresectable metastatic gastric cancer. The training sets were downloaded from GEO datasets (GSE26253 and GSE14208)...
December 12, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29231918/-systemic-treatment-of-early-breast-cancer-current-state-of-knowledge-after-the-conference-st-gallen-2017
#6
REVIEW
Tomasz Sarosiek
Breast cancer is the most commonly diagnosed malignancy in women around the globe. It is also the world's first cause of female deaths from cancer. With the introduction of screening programs in most developed countries, more and more cases of this cancer are diagnosed at local or localized stages, enabling radical treatment to be successful. At the same time, systemic treatment of early breast cancer is one of the most complex issues in clinical oncology. Because of the many prognostic factors that need to be taken into account when considering eligibility for treatment such as age, reproductive status (before or after menopause), type of cancer and severity of the disease, it is impossible to establish clear standards of conduct for many clinical situations...
November 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29231356/-acupuncture-for-diarrhea-predominant-irritable-bowel-syndrome-a-meta-analysis
#7
REVIEW
Duoxi Deng, Kuikui Guo, Jie Tan, Guilan Huang, Shuai Li, Quanrui Jiang, Jiao Xie, Hui Xie, Zhiqi Zhang, Ying Chen, Liang Peng
OBJECTIVE: To systematically evaluate the efficacy and safety of acupuncture on diarrhea-predominant irritable bowel syndrome (IBS) in the past five years. METHODS: Online databases, including CNKI, VIP, WANFANG, PubMed, CBM, ScienceDirect OnSite, Cochrane Library, etc. were searched for randomized controlled trials (RCTs) of acupuncture for diarrhea-predominant IBS. Retrieval time was from January of 2011 to January of 2016. According to modified Jadad standard, the bias risk and quality assessment of each RCT included were evaluated by two researchers...
August 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231146/comparison-of-two-naloxone-regimens-in-addicted-methadone-overdosed-patients-a-clinical-trial-study
#8
Navid Khosravi, Nasim Zamani, Hossein Hassanian-Moghaddam, Ali Ostadi, Mitra Rahimi, Ali Kabir
BACKGROUND: Methadone toxicity is one of the major causes of death in opioid dependent individuals. OBJECTIVE: We aimed to compare two different protocols for naloxone in terms of reversal of overdose and frequency of complications in opioid-dependent methadone-intoxicated patients. METHODS: One-hundred opioid-dependent patients with signs/symptoms of methadone overdose were included. The patients were consecutively assigned into Tintinalli (group 1) or Goldfrank regimen protocol (group 2) of naloxone administration...
December 11, 2017: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/29231094/edoxaban-for-the-treatment-of-cancer-associated-venous-thromboembolism
#9
Gary E Raskob, Nick van Es, Peter Verhamme, Marc Carrier, Marcello Di Nisio, David Garcia, Michael A Grosso, Ajay K Kakkar, Michael J Kovacs, Michele F Mercuri, Guy Meyer, Annelise Segers, Minggao Shi, Tzu-Fei Wang, Erik Yeo, George Zhang, Jeffrey I Zwicker, Jeffrey I Weitz, Harry R Büller
Background Low-molecular-weight heparin is the standard treatment for cancer-associated venous thromboembolism. The role of treatment with direct oral anticoagulant agents is unclear. Methods In this open-label, noninferiority trial, we randomly assigned patients with cancer who had acute symptomatic or incidental venous thromboembolism to receive either low-molecular-weight heparin for at least 5 days followed by oral edoxaban at a dose of 60 mg once daily (edoxaban group) or subcutaneous dalteparin at a dose of 200 IU per kilogram of body weight once daily for 1 month followed by dalteparin at a dose of 150 IU per kilogram once daily (dalteparin group)...
December 12, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29230662/relationship-of-histologic-grade-and-histologic-subtype-with-oncotype-dx-recurrence-score-retrospective-review-of-863-breast-cancer-oncotype-dx-results
#10
Kamaljeet Singh, Xin He, Elizabeth T Kalife, Shahrzad Ehdaivand, Yihong Wang, C James Sung
PURPOSE: Oncotype Dx (ODx) is a multigene assay that is prognostic and predictive in estrogen receptor (ER) positive early breast cancer. ODx recurrence score (RS) is reported to be histologic grade dependent. Relationship of RS with breast cancer histologic subtypes is unknown. This study was designed to assess the relationship of histologic subtype with RS. Histologic grade dependence of RS was also investigated. METHODS: Results of consecutive ODx tests (1/2007-7/2016) from two institutions were reviewed...
December 11, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29230296/intestinal-autotransplantation
#11
REVIEW
Guosheng Wu
Most abdominal neoplasms involving the root of the superior mesenteric artery and/or celiac artery are difficult to manage with conventional operative techniques because of limited intestinal ischemia times and poor accessibility to the tumor region. Ex vivo surgery followed by intestinal autotransplantation (IATx) is a relatively novel surgical strategy to offer chances for complete resection in such hopeless circumstances. This review aims to assess potential surgical indications, operative techniques and clinical outcomes after IATx...
November 2017: Gastroenterology Report
https://www.readbyqxmd.com/read/29230144/risk-stratification-for-prevention-of-recurrence-of-postoperative-crohn-s-disease
#12
Shirley Cohen-Mekelburg, Yecheskel Schneider, Stephanie Gold, Ellen Scherl, Adam Steinlauf
Although there have been significant advances in medical therapies to treat Crohn's disease, an estimated 50% of patients will require surgery within the first decade of disease duration. Of these patients, a substantial number will develop recurrent symptoms within the first postoperative year. To prevent disease recurrence, many physicians use postoperative prophylactic therapy. Randomized, controlled trials, although limited in number, have demonstrated that a prophylactic postoperative strategy is effective at reducing recurrence (both clinical and endoscopic) in high-risk patients...
November 2017: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29230008/positive-margin-length-and-highest-gleason-grade-of-tumor-at-the-margin-predict-for-biochemical-recurrence-after-radical-prostatectomy-in-patients-with-organ-confined-prostate-cancer
#13
Brian F Chapin, Jenny N Nguyen, Mary F Achim, Neema Navai, Stephen B Williams, Ina N Prokhorova, Xuemei Wang, Elsa M Li Ning Tapia, John W Davis, Patricia Troncoso
BACKGROUND: To evaluate the pathologic features after radical prostatectomy to determine if the length of positive surgical margin (PSM) and the highest Gleason grade within the tumor at the PSM could risk stratify patients for biochemical recurrence (BCR). METHODS: We performed a retrospective, matched, cohort study to identify patients with pathologically organ-confined (pT2) tumors and negative nodes (pN0/Nx), receiving no adjuvant therapy. Specimens underwent single pathologist review...
December 11, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29229726/prognostic-significance-of-blood-pressure-variability-on-beat-to-beat-monitoring-after-transient-ischemic-attack-and-stroke
#14
Alastair J S Webb, Sara Mazzucco, Linxin Li, Peter M Rothwell
BACKGROUND AND PURPOSE: Visit-to-visit and day-to-day blood pressure (BP) variability (BPV) predict an increased risk of cardiovascular events but only reflect 1 form of BPV. Beat-to-beat BPV can be rapidly assessed and might also be predictive. METHODS: In consecutive patients within 6 weeks of transient ischemic attack or nondisabling stroke (Oxford Vascular Study), BPV (coefficient of variation) was measured beat-to-beat for 5 minutes (Finometer), day-to-day for 1 week on home monitoring (3 readings, 3× daily), and on awake ambulatory BP monitoring...
December 11, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29229649/isolated-tricuspid-regurgitation-outcomes-and-therapeutic-interventions
#15
REVIEW
Erin A Fender, Chad J Zack, Rick A Nishimura
Isolated tricuspid regurgitation (TR) can be caused by primary valvular abnormalities such as flail leaflet or secondary annular dilation as is seen in atrial fibrillation, pulmonary hypertension and left heart disease. There is an increasing recognition of a subgroup of patients with isolated TR in the absence of other associated cardiac abnormalities. Left untreated isolated TR significantly worsens survival. Stand-alone surgery for isolated TR is rarely performed due to an average operative mortality of 8%-10% and a paucity of data demonstrating improved survival...
December 11, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29229573/merkel-cell-carcinoma-an-update-and-review-part-ii-current-and-future-therapy
#16
REVIEW
Tiffany L Tello, Kathleen Coggshall, Sue S Yom, Siegrid S Yu
Merkel cell carcinoma (MCC) is a rare neuroendocrine tumor of the skin associated with a high risk of local recurrence and distant metastases. It most commonly occurs on sun-exposed areas of Caucasian patients over the age of 65.1,2 The Merkel cell polyomavirus (MCV) is thought to be responsible for malignant transformation in approximately 80% of cases in the northern hemisphere,3 while ultraviolet radiation induced DNA damage is implicated in MCV-negative tumors.4 The overall incidence of MCC is low, with approximately 1600 cases diagnosed annually in the United States...
December 8, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29229545/fabrication-of-hybrid-crosslinked-network-with-buffering-capabilities-and-autonomous-strengthening-characteristics-for-dental-adhesive
#17
Linyong Song, Qiang Ye, Xueping Ge, Anil Misra, Candan Tamerler, Paulette Spencer
Ingress of bacteria and fluids at the interfacial gaps between the restorative composite biomaterial and the tooth structure contribute to recurrent decay and failure of the composite restoration. The inability of the material to increase the pH at the composite/tooth interface facilitates the outgrowth of bacteria. Neutralizing the microenvironment at the tooth/composite interface offers promise for reducing the damage provoked by cariogenic and aciduric bacteria. We address this problem by designing a dental adhesive composed of hybrid network to provide buffering and autonomous strengthening simultaneously...
December 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29229471/patent-foramen-ovale-closure-for-secondary-prevention-of-cryptogenic-stroke-updated-meta-analysis-of-randomized-clinical-trials
#18
Muthiah Vaduganathan, Arman Qamar, Ankur Gupta, Navkaranbir Bajaj, Harsh B Golwala, Ambarish Pandey, Deepak L Bhatt
BACKGROUND: Patent foramen ovale closure represents a potential secondary prevention strategy for cryptogenic stroke, but available trials have varied by size, device studied, and follow-up. METHODS: We conducted a systematic search of published randomized clinical trials (RCTs) evaluating patent foramen ovale closure vs. medical therapy in patients with recent stroke or transient ischemic attack using PubMED, EMBASE, and Cochrane through September 2017. Weighting was by random effects models...
December 8, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29229310/tumor-volume-predicts-local-recurrence-in-early-rectal-cancer-treated-with-radical-resection-a-retrospective-observational-study-of-270-patients
#19
Yanhui Jiang, Kaiyun You, Xingsheng Qiu, Zhuofei Bi, Huaqian Mo, Liting Li, Yimin Liu
OBJECTIVE: Radical resection is regarded as the primary treatment for early rectal cancer, and tumor volume is an independent predictor of many other types of cancer. The purpose of the present study is to assess the effect of tumor volume on the survival of patients with early rectal cancer treated with radical surgery. METHODS: A total of 270 patients with histologically confirmed stage T1/2 N0 rectal cancer who underwent radical resection between September 2006 and September 2014 were enrolled in this study...
December 8, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29229309/interaction-of-margin-status-and-tumour-burden-determines-survival-after-resection-of-colorectal-liver-metastases-a-retrospective-cohort-study
#20
Rui Mao, Jian-Jun Zhao, Xin-Yu Bi, Ye-Fan Zhang, Zhi-Yu Li, Jian-Guo Zhou, Hong Zhao, Jian-Qiang Cai
PURPOSE: We sought to determine the impact of surgical margin status on overall survival (OS) and recurrence pattern stratified by tumor burden. MATERIALS AND METHODS: Data were collected from patients undergoing resection for colorectal liver metastases (CRLM). Tumor burden was calculated according to a newly proposed Tumor Burden Score (TBS) system, defined as the distance from the origin on a Cartesian plane that incorporated maximum tumor size and number of liver lesions...
December 8, 2017: International Journal of Surgery
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