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https://www.readbyqxmd.com/read/29031036/-the-role-of-chemotherapy-in-the-treatment-of-low-grade-gliomas
#1
R Lakomý, T Kazda, A Poprach, P Pospíšil, R Jančálek, P Šlampa
BACKGROUND: The standard postsurgical options for low-grade gliomas include watchful waiting or radiotherapy depending on the risk factors for recurrence. The use of chemotherapy for the treatment of this disease is generally controversial, although the recently published results of the first of two large randomized phase III clinical trials (RTOG 9802 a EORTC 22033-26033), focusing on the evaluation of chemotherapy for the upfront treatment of newly diagnosed low-grade gliomas, are reassuring in this respect...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29031032/the-frequency-and-clinical-implications-of-bacteriuria-in-chronically-paralyzed-dogs
#2
S R Baigi, S Vaden, N J Olby
BACKGROUND: Paralysis is a known risk factor for urinary tract infections (UTI), sepsis, and death in paralyzed people, but there are no data available on diagnostic criteria for UTI versus bacteriuria, their frequency, or clinical implications in chronically paralyzed dogs. HYPOTHESIS/OBJECTIVES: That chronically paralyzed dogs suffer frequent bacteriuria causing reduced duration of survival. We documented the frequency of bacteriuria, associated clinical signs, and survival rate in chronically paralyzed dogs...
October 14, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29029108/relative-risks-of-contributing-factors-to-morbidity-and-mortality-in-adults-with-craniopharyngioma-on-gh-replacement
#3
Kevin C J Yuen, Anders F Mattsson, Pia Burman, Eva-Marie Erfurth, Cecilia Camacho-Hubner, Janet L Fox, Johan Verhelst, Mitchell E Geffner, Roger Abs
Context: Craniopharyngioma (CP) in adults, of either childhood-onset (CO-CP) or adult-onset (AO-CP), is associated with increased morbidity and mortality, but data on the relative risks (RRs) of contributing factors are lacking. Objective: To assess the RRs of factors contributing to morbidity and mortality of adults with CO-CP and AO-CP. Methods: Data on 1,669 CP patients from KIMS (Pfizer International Metabolic Database) were analyzed using univariate and multiple Poisson and Cox regression methods...
September 29, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29028664/abacavir-use-and-risk-of-recurrent-myocardial-infarction-the-d-a-d-study
#4
Caroline A Sabin, Lene Ryom, Antonella d'Arminio Monforte, Camilla I Hatleberg, Christian Pradier, Wafaa El-Sadr, Ole Kirk, Rainer Weber, Andrew N Phillips, Amanda Mocroft, Fabrice Bonnet, Matthew Law, Stephane de Wit, Peter Reiss, Jens D Lundgren
OBJECTIVE: To investigate the association between abacavir (ABC) use and recurrent myocardial infarction (MI) among HIV-positive people with a prior MI. DESIGN: International multi-cohort collaboration with follow-up from 1999-2016. METHODS: The rate of recurrent MI was described among D:A:D participants who experienced an index MI whilst in the study, and who remained under follow-up beyond 28 days after this MI. Follow-up was considered to the date of next MI, death, 01/Feb/2016 or 6 months after last clinic visit...
October 12, 2017: AIDS
https://www.readbyqxmd.com/read/29028584/diagnosis-and-treatment-options-for-sequelae-following-radiation-treatment-of-brain-tumors
#5
REVIEW
Swapnil Mehta, Aatman Shah, Henry Jung
Radiation serves an important role in the treatment of metastatic and primary brain tumors. Radiation carries a risk of post radiation treatment effects, such as pseudoprogression and radiation necrosis. The ability to differentiate between radiation necrosis, pseudoprogression, and tumor recurrence remains a diagnostic conundrum with varying treatment options. In this review, we will discuss the pathophysiology, diagnostic imaging modalities, and treatments of these post-radiation treatment effects. We focus on the latest developments in magnetic resonance imaging (MRI) modalities including imaging biomarkers and the newest therapeutics such as VEGF inhibitors, Hyperbaric Oxygen Therapy, sensitized cytotoxic T cells, and Laser Interstitial Thermal Therapy (LITT)...
October 7, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29028452/atrial-fibrillation-in-women-risks-and-management
#6
Sindhu Prabakaran, Maria Carolina Gongora Nieto, Gina Lundberg
Atrial fibrillation (AF) is one of the most commonly occurring arrhythmias and a major modifiable risk factor for stroke, especially in women. While its prevalence is similar in both men and women, women unfortunately face a greater intrinsic AF-related risk of stroke than men do. This is likely one of the reasons that more women than men die from strokes, in addition to experiencing more new and recurrent strokes. Therefore, in women especially, it is imperative to diagnose and treat AF as early as possible...
October 13, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/29027628/the-prognostic-significance-of-measurable-minimal-residual-disease-in-acute-myeloid-leukemia
#7
REVIEW
Francesco Buccisano, Christopher S Hourigan, Roland B Walter
PURPOSE OF REVIEW: The purpose of this review was to evaluate recent literature on detection methodologies for, and prognostic significance of, measurable ("minimal") residual disease (MRD) in acute myeloid leukemia (AML). RECENT FINDINGS: There is no "one-fits-all" approach to MRD testing in AML. Most exploited to date are methods relying on immunophenotypic aberrancies (identified via multiparameter flow cytometry) or genetic abnormalities (identified via PCR-based assays)...
October 13, 2017: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/29027568/-diagnostics-and-treatment-of-acromegaly-necessity-for-targeted-monitoring-of-comorbidities
#8
S Petersenn, M Christ-Crain, M Droste, R Finke, J Flitsch, I Kreitschmann-Andermahr, A Luger, J Schopohl, G Stalla
Acromegaly is a rare and severe condition, presenting with typical signs and symptoms. The diagnosis is often initially made years after the first manifestations of the disease. In more than 99% of patients the disease is caused by a benign pituitary tumor that secretes growth hormone (GH). The diagnosis is based on the presence of increased insulin-like growth factor 1 (IGF-1) levels and a lack of GH suppression in the oral glucose tolerance test. The standard imaging procedure for tumor detection is magnetic resonance imaging in the region of the sella turcica...
October 13, 2017: Der Internist
https://www.readbyqxmd.com/read/29027536/kras-mutation-of-extraovarian-implants-of-serous-borderline-tumor-prognostic-indicator-for-adverse-clinical-outcome
#9
Tao Zuo, Serena Wong, Natalia Buza, Pei Hui
In contrast to non-invasive extraovarian implants, invasive implants of ovarian serous borderline tumor/atypical proliferative serous tumor are associated with adverse outcome and have been reclassified as low-grade serous carcinoma. Mutations of KRAS and/or BRAF have been reported in up to 50% of serous borderline tumor/atypical proliferative serous tumor. We investigated KRAS and BRAF mutation frequencies in the two types of implants of serous borderline tumor/atypical proliferative serous tumor in correlation with clinical outcome...
October 13, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29027402/impact-of-vaginal-cylinder-diameter-on-outcomes-following-brachytherapy-for-early-stage-endometrial-cancer
#10
Jack M Qian, John M Stahl, Melissa R Young, Elena Ratner, Shari Damast
OBJECTIVE: To examine the outcomes (tolerability, toxicity, and recurrence) of vaginal brachytherapy (VBT) among endometrial cancer (EC) patients treated with small cylinder size. METHODS: Patients with EC who received adjuvant VBT between September 2011 and December 2015 were reviewed. Patients were fitted with the largest vaginal cylinder they could comfortably accommodate, from 2.0-3.0 cm diameter. Small cylinders were defined as size 2.3 cm or less. Patient, tumor, or treatment characteristics were correlated with need for small cylinders...
November 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29027395/prognostic-value-of-programmed-death-ligand-1-pd-l1-expression-in-ovarian-clear-cell-carcinoma
#11
Jun Zhu, Hao Wen, Rui Bi, Yong Wu, Xiaohua Wu
OBJECTIVE: Programmed death-ligand 1 (PD-L1) was expressed in various tumors and antibodies targeting its receptor programmed cell death-1 (PD-1) are emerging cancer therapeutics. This study was designed to evaluate the expression of PD-L1 and its correlation with clinicopathologic features and clinical outcomes in ovarian clear cell carcinoma (OCCC). METHODS: The PD-L1 expression was measured by tissue-microarray-based immunohistochemistry from 122 eligible patients diagnosed with OCCC...
November 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29027394/assessing-the-effect-of-guideline-introduction-on-clinical-practice-and-outcome-in-patients-with-endometrial-cancer-in-japan-a-project-of-the-japan-society-of-gynecologic-oncology-jsgo-guideline-evaluation-committee
#12
Shogo Shigeta, Satoru Nagase, Mikio Mikami, Masae Ikeda, Masako Shida, Isao Sakaguchi, Norichika Ushioda, Fumiaki Takahashi, Wataru Yamagami, Nobuo Yaegashi, Yasuhiro Udagawa, Hidetaka Katabuchi
OBJECTIVE: The Japan Society of Gynecologic Oncology (JSGO) published the first practice guideline for endometrial cancer in 2006. The JSGO guideline evaluation committee assessed the effect of this guideline introduction on clinical practice and patient outcome using data provided by the Japan Society of Obstetrics and Gynecology (JSOG) cancer registration system. METHODS: Data of patients with endometrial cancer registered between 2000 and 2012 were analyzed, and epidemiological and clinical trends were assessed...
November 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29027327/laparoscopic-ventral-hernia-repair-using-only-5-mm-ports
#13
Nicholas Bell-Allen, Harriet O'Rourke, Lisa Hong, Nicholas O'Rourke
BACKGROUND: The technique of laparoscopic ventral hernia repair has been evolving since it was first described over 20 years ago. We report a new technique where polyester mesh was back loaded through a 5-mm port site, coming into contact with the skin. This avoids the need for any 10-12-mm ports. METHODS: A prospective database of laparoscopic ventral hernia repairs was examined. A single surgeon performed 344 laparoscopic ventral hernia repairs using this technique over 60 months...
October 12, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29027157/animal-models-for-bipolar-disorder-from-bedside-to-the-cage
#14
REVIEW
Dominik K E Beyer, Nadja Freund
Bipolar disorder is characterized by recurrent manic and depressive episodes. Patients suffering from this disorder experience dramatic mood swings with a wide variety of typical behavioral facets, affecting overall activity, energy, sexual behavior, sense of self, self-esteem, circadian rhythm, cognition, and increased risk for suicide. Effective treatment options are limited and diagnosis can be complicated. To overcome these obstacles, a better understanding of the neurobiology underlying bipolar disorder is needed...
October 13, 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29026972/retroperitoneal-lymph-node-dissection-for-testicular-seminomas-population-based-practice-and-survival-outcomes
#15
Hiten D Patel, Gregory A Joice, Zeyad R Schwen, Alice Semerjian, Ridwan Alam, Arnav Srivastava, Mohamad E Allaf, Phillip M Pierorazio
PURPOSE: While retroperitoneal lymph node dissection (RPLND) is traditionally reserved for nonseminomatous germ cell tumors, recent efforts to reduce long-term toxicities of radiation and chemotherapy have turned attention to its application for testicular seminomas. Currently, RPLND is reserved for the post-chemotherapy for stage II testicular seminomas; we aimed to describe current utilization of RPNLD for testicular seminomas by stage and implications for survival. METHODS: A national sample of men diagnosed with stage IA/IB/IS/IIA/IIB/IIC testicular seminoma (1988-2013) was evaluated from SEER Program registries...
October 12, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29026942/the-effects-of-subclinical-neck-pain-on-sensorimotor-integration-following-a-complex-motor-pursuit-task
#16
Danielle Andrew, Paul Yielder, Heidi Haavik, Bernadette Murphy
Recurrent subclinical neck pain (SCNP) may be associated with neural plastic changes in sensory processing and sensorimotor integration (SMI); however, its impact on motor learning has not been investigated. The aim of this study was to investigate whether SCNP alters neural markers of SMI during a complex motor acquisition task as compared to a healthy control group. Peripheral N9, spinal N13, brainstem N18, and cortical N20, P25, N24 and N30 early somatosensory evoked potentials (SEPs) were recorded following median nerve stimulation for 24 participants (12 control and 12 SCNP) before and after a 10-min tracing motor task intervention...
October 12, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29026764/a-case-control-study-on-environmental-and-biological-risk-factors-for-renal-calculi-persisting-in-a-coastal-union-territory-india
#17
Prakash Mathiyalagen, Anand Neelakantan, Karthik Balusamy, Kavita Vasudevan, Johnson Cherian, Bhuvaneswary Sunderamurthy
BACKGROUND AND OBJECTIVES: Renal stone disease is a common disorder of the urinary tract and also a significant problem because of incidence, recurrence, and severe consequences. The complex pathogenetic mechanisms of renal stone formation involve both biologic and environmental risk factors. The present study was performed to identify the role of these parameters among renal stone patients and normal individuals from a coastal union territory region in South India. METHODS: The authors conducted a case-control study of renal stone disease among outpatient department patients more than 30 years of age using systematic random sampling procedure with 100 study participants (50 subjects for each group)...
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29026722/mthfr-3-untranslated-region-polymorphisms-contribute-to-recurrent-pregnancy-loss-risk-and-alterations-in-peripheral-natural-killer-cell-proportions
#18
Eun Sun Kim, Jung Oh Kim, Hui Jeong An, Jung Hyun Sakong, Hyun Ah Lee, Ji Hyang Kim, Eun Hee Ahn, Young Ran Kim, Woo Sik Lee, Nam Keun Kim
OBJECTIVE: To identify the associations between polymorphisms of the 3'-untranslated region (UTR) of methylenetetrahydrofolate reductase (MTHFR) gene, which codes for an important regulatory enzyme primarily involved in folate metabolism, and idiopathic recurrent pregnancy loss (RPL) in Korean women. METHODS: The study population comprised 369 RPL patients and 228 controls. MTHFR 2572C>A, 4869C>G, 5488C>T, and 6685T>C 3'-UTR polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism analysis or by TaqMan allelic discrimination assays...
September 2017: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/29026675/advantages-of-using-a-detachable-tip-microcatheter-and-liquid-embolic-agents-in-the-preoperative-embolization-of-a-recurrent-cerebellar-hemangioblastoma-a-case-report
#19
Nicolas Yanez, Luisa K Cifuentes, Marcela Mejia, Juan N Useche
BACKGROUND: The preferred treatment for intracranial hemangioblastomas is surgical resection with or without preoperative embolization, however, embolization remains controversial due to risks such as distal tip entrapment, vascular injury during navigation, and embolic agent migration. CASE DESCRIPTION: A 54-year-old woman was admitted for surgical resection and preoperative embolization of a cerebellar hemangioblastoma. Although experience using Onyx with detachable and nondetachable tip microcatheters has been well reported in a variety of clinical circumstances, we describe the first case of a presurgical embolization of an intra-axial tumor using a second-generation detachable-tip microcatheter and a nonadhesive liquid embolic agent...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29026632/salmonella-oranienburg-haemorrhagic-cystitis-in-an-immunocompetent-young-male
#20
Jiasian Teh, Mark Quinlan, Damien Bolton
Introduction. Non-typhoidal salmonella (NTS) bacteriuria is extremely rare. Haemorrhagic cystitis is defined by urinary symptoms including haematuria, frequency, urgency and dysuria. Reports of haemorrhagic cystitis caused by NTS are exceptionally uncommon, especially in immunocompetent, young, male patients. Case presentation. A 27-year-old male with no past medical history presented to the Emergency Department with a 24 h history of visible haematuria having returned five days earlier from a five month trip across South America...
August 2017: JMM Case Reports
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