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https://www.readbyqxmd.com/read/29027157/animal-models-for-bipolar-disorder-from-bedside-to-the-cage
#1
REVIEW
Dominik K E Beyer, Nadja Freund
Bipolar disorder is characterized by recurrent manic and depressive episodes. Patients suffering from this disorder experience dramatic mood swings with a wide variety of typical behavioral facets, affecting overall activity, energy, sexual behavior, sense of self, self-esteem, circadian rhythm, cognition, and increased risk for suicide. Effective treatment options are limited and diagnosis can be complicated. To overcome these obstacles, a better understanding of the neurobiology underlying bipolar disorder is needed...
October 13, 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29024821/improving-the-efficiency-of-psychological-treatment-using-outcome-feedback-technology
#2
Jaime Delgadillo, Karen Overend, Mike Lucock, Martin Groom, Naomi Kirby, Dean McMillan, Simon Gilbody, Wolfgang Lutz, Julian A Rubel, Kim de Jong
AIMS: This study evaluated the impact of applying computerized outcome feedback (OF) technology in a stepped care psychological service offering low and high intensity therapies for depression and anxiety. METHODS: A group of therapists were trained to use OF based on routine outcome monitoring using depression (PHQ-9) and anxiety (GAD-7) measures. Therapists regularly reviewed expected treatment response graphs with patients and discussed cases that were "not on track" in clinical supervision...
September 28, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29023805/intracranial-source-activity-eloreta-related-to-scalp-level-asymmetry-scores-and-depression-status
#3
Ezra E Smith, James F Cavanagh, John J B Allen
Frontal EEG alpha asymmetry provides a promising index of depression risk, yet very little is known about the neural sources of alpha asymmetry. To identify these sources, this study examined alpha asymmetry using a distributed inverse solution: exact low resolution brain electromagnetic tomography (eLORETA). Findings implicated a generator in lateral midfrontal regions that contributed to both surface asymmetry and depression risk. Participants with any lifetime history of depressive episodes were characterized by less left than right activity in the precentral gyrus and midfrontal gyrus...
October 11, 2017: Psychophysiology
https://www.readbyqxmd.com/read/29022840/irritable-temperament-and-lifetime-psychotic-symptoms-as-predictors-of-anxiety-symptoms-in-bipolar-disorder
#4
Gianluca Serafini, Pierre A Geoffroy, Andrea Aguglia, Giulia Adavastro, Giovanna Canepa, Maurizio Pompili, Mario Amore
PURPOSE: Affective temperaments, hopelessness, alexithymia, and anxiety/agitation symptoms may play a significant role in the psychopathological characteristics of bipolar disorder (BD). Here, we aimed to investigate the eventual association between the mentioned explanatory variables and anxiety/agitation symptoms in BD. MATERIALS AND METHODS: We recruited at the Section of Psychiatry, Department of Neuroscience, University of Genoa (Italy), 92 BD inpatients having a mean age of 52 (±13...
October 12, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29017795/long-term-effects-of-sleep-deprivation-on-neuronal-activity-in-four-hypothalamic-areas
#5
Karim Fifel, Johanna H Meijer, Tom Deboer
Lack of adequate sleep has become increasingly common in our 24/7 society. Unfortunately diminished sleep has significant health consequences including metabolic and cardiovascular disease and mental disorders including depression. The pathways by which reduced sleep adversely affects physiology and behavior are unknown. We found that 6h of sleep deprivation in adult male rats induces changes in neuronal activity in the lateral hypothalamus, the paraventricular nucleus, the arcuate nucleus and the mammillary bodies...
October 7, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/29017067/clinically-relevant-response-and-remission-outcomes-in-cariprazine-treated-patients-with-bipolar-i-disorder
#6
Willie Earley, Suresh Durgam, Kaifeng Lu, Adam Ruth, György Németh, István Laszlovszky, Lakshmi N Yatham
BACKGROUND: Rates of response and remission are measures that endorse the clinical significance of treatment. Cariprazine is FDA approved for the acute treatment of schizophrenia and manic or mixed episodes associated with bipolar I disorder in adults. Post hoc analyses of pooled data from 3 pivotal trials of cariprazine in manic/mixed episodes associated with bipolar I disorder were conducted to investigate the effect of cariprazine on various criteria of response and remission. METHODS: The constituent studies were 3-week randomized, double-blind, placebo-controlled, multicenter, parallel-group phase II/III studies in adult patients (age 18-65 years) with bipolar I disorder (NCT00488618, NCT01058096, NCT01058668)...
September 25, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29016937/screening-for-insomnia-an-observational-study-examining-sleep-disturbances-headache-characteristics-and-psychiatric-symptoms-in-patients-visiting-a-headache-center
#7
Olivia Begasse de Dhaem, Elizabeth Seng, Mia T Minen
Objective: Effective treatments for insomnia exist, but few physicians treating headaches have routine methods for screening for insomnia. We sought to 1) describe the migraine characteristics and comorbid conditions that can affect sleep and 2) assess their relationships with positive screens on the Insomnia Severity Index (ISI). Methods: This is a retrospective cross-sectional study of the migraine and sleep characteristics of new patients in our headache center (August 15, 2015-October 28, 2015) who were suspected of having migraines based on the new patient intake questionnaire...
July 21, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28993004/cerebral-amyloid-angiopathy-related-cognitive-impairment-the-search-for-a-specific-neuropsychological-pattern
#8
REVIEW
M Planton, N Raposo, J-F Albucher, J Pariente
Cerebral amyloid angiopathy is diagnosed in stroke units after lobar intracerebral hemorrhage. CAA can also be diagnosed in memory clinics when patients are referred for cognitive impairment assessment, and may be a reason for admission to emergency or neurology departments because of rapidly progressive cognitive or neurological decline, or a transient focal neurological episode. CAA may even be observed in older community-dwelling individuals. Neuropsychological impairment in CAA has been described over the past 20 years...
October 6, 2017: Revue Neurologique
https://www.readbyqxmd.com/read/28988166/loneliness-and-depression-among-rural-empty-nest-elderly-adults-in-liuyang-china-a-cross-sectional-study
#9
Guojun Wang, Mi Hu, Shui-Yuan Xiao, Liang Zhou
OBJECTIVE: To compare loneliness, depressive symptoms and major depressive episodes between empty-nest and not-empty-nest older adults in rural areas of Liuyang city, Hunan, China. METHODS: A cross-sectional multi-stage random cluster survey was conducted from November 2011 to April 2012 in Liuyang, China. A total of 839 rural older residents aged 60 or above completed the survey (response rate 97.6%). In line with the definition of empty nest, 25 participants who had no children were excluded from the study, while the remaining 814 elderly adults with at least one child were included for analysis...
October 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28988102/number-of-illness-episodes-as-predictor-of-residual-symptoms-in-major-depressive-disorder
#10
Gianluca Serafini, Jacopo Nebbia, Nicolò Cipriani, Claudia Conigliaro, Denise Erbuto, Maurizio Pompili, Mario Amore
Notwithstanding major depressive disorder (MDD) is a recurring and chronic condition, relatively few variables have consistently been shown to predict its course. Residual depressive symptoms may be associated with disability and functional impairment but few studies evaluated clinical correlates associated with these symptoms and their impact on functioning after adjustment for potential confounders. Therefore, our study aimed to investigate factors associated with residual depressive symptoms and their impact on the course of MDD...
September 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28986416/subjective-cognitive-decline-and-%C3%AE-amyloid-burden-predict-cognitive-change-in-healthy-elderly
#11
Jacob W Vogel, Monika Varga Doležalová, Renaud La Joie, Shawn M Marks, Henry D Schwimmer, Susan M Landau, William J Jagust
OBJECTIVE: To assess in a longitudinal study whether subjective cognitive decline (SCD) and brain β-amyloid (Aβ) contribute unique information to cognitive decline. METHODS: One hundred thirty-six healthy elderly from the Berkeley Aging Cohort Study were followed up for a mean of 4 years. SCD and affective measures were generated from the Geriatric Depression Scale (GDS) with factor analysis on data from a larger set of 347 healthy, nondepressed (GDS <11) elderly individuals...
October 6, 2017: Neurology
https://www.readbyqxmd.com/read/28982553/depression-during-first-episode-psychosis-and-subsequent-suicide-risk-a-systematic-review-and-meta-analysis-of-longitudinal-studies
#12
REVIEW
Jessica McGinty, M Sayeed Haque, Rachel Upthegrove
BACKGROUND: Evidence suggests first episode psychosis (FEP) is associated with suicide, and the influence of depression on suicidal behaviour in cross sectional studies is clear. However the influence of depression during FEP on longer-term mortality is not certain. Existing evidence was synthesised to understand the influence of depressive symptoms during FEP on subsequent suicidal behaviour. METHODS: Medline, Embase, PsycINFO, Cochrane Library, Web of Science, OpenGrey, and NICE Evidence were searched from inception to Jan 25, 2017...
October 2, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28981917/aberrant-default-mode-network-hippocampus-connectivity-after-sad-memory-recall-in-remitted-depression
#13
Caroline A Figueroa, Roel J T Mocking, Guido van Wingen, Suzanne Martens, Henricus G Ruhé, Aart H Schene
Rumination and cognitive reactivity (dysfunctional cognitions after sad mood-induction) remain high in remitted Major Depressive Disorder (MDD) and can contribute to new episodes. These factors have been linked to increased fMRI resting-state functional-connectivity within the Default-Mode Network (DMN). It remains unclear whether (I) increased DMN-connectivity persists during MDD-remission, and (II) whether sad mood-induction differentially affects DMN-connectivity in remitted-MDD versus controls. Moreover, DMN-connectivity studies in remitted-MDD were previously confounded by antidepressant-use...
September 13, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28981913/olfactory-functioning-in-first-episode-psychosis
#14
Vidyulata Kamath, Patricia Lasutschinkow, Koko Ishizuka, Akira Sawa
BACKGROUND: Though olfactory deficits are well-documented in schizophrenia, fewer studies have examined olfactory performance profiles across the psychosis spectrum. The current study examined odor identification, discrimination, and detection threshold performance in first-episode psychosis (FEP) patients diagnosed with schizophrenia, schizoaffective disorder, bipolar disorder with psychotic features, major depression with psychotic features, and other psychotic conditions. METHOD: FEP patients (n = 97) and healthy adults (n = 98) completed birhinal assessments of odor identification, discrimination, and detection threshold sensitivity for lyral and citralva...
August 31, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28981811/prospective-relationships-between-motivation-and-functioning-in-recovery-after-a-first-episode-of-schizophrenia
#15
Daniel Fulford, Danijela Piskulic, Jean Addington, John M Kane, Nina R Schooler, Kim T Mueser
Diminished motivation is associated with robust impairment in psychosocial functioning in schizophrenia (SZ). Little is known about the reciprocal relationships between motivation and functioning, particularly following a first episode of psychosis. We tested bidirectional associations between motivation and social and occupational functioning in the year following a first episode of SZ spectrum disorder among patients in the Recovery After an Initial Schizophrenia Episode-Early Treatment Program (RAISE-ETP) study...
August 18, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28979994/factors-associated-with-30-day-readmission-after-primary-total-hip-arthroplasty-analysis-of-514%C3%A2-455-procedures-in-the-uk-national-health-service
#16
Adam M Ali, Mark D Loeffler, Paul Aylin, Alex Bottle
Importance: Thirty-day readmission to hospital after total hip arthroplasty (THA) has significant direct costs and is used as a marker of hospital performance. All-cause readmission is the only metric in current use, and risk factors for surgical readmission and those resulting in return to theater (RTT) are poorly understood. Objective: To determine whether patient-related predictors of all-cause, surgical, and RTT readmission after THA differ and which predictors are most significant...
October 4, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28979648/screening-of-the-unrecognised-bipolar-disorders-among-outpatients-with-recurrent-depressive-disorder-a-cross-sectional-study-in-psychiatric-hospital-in-morocco
#17
Oneib Bouchra, Sabir Maria, Ouanass Abderazak
The bipolar disorder is often misdiagnosed in particular among outpatients with recurrent depression. Indeed, this work confirmed that the unrecognised bipolar disorder is common among depressed outpatients, which were younger, unemployed, single or divorced with a low socio-economic level. These socio-demographics data gives us an idea about the disability experienced by the unknown bipolar patients. Also, we demonstrate that the under-diagnosis bipolar disorder was associated with the earliest onset age of a depressive episode and it was more prevalent in depressed patients with suicidal ideation and suicide attempts...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28978214/strategies-to-manage-costs-in-idiopathic-pulmonary-fibrosis
#18
Gary M Owens
Idiopathic pulmonary fibrosis (IPF) is a diagnostically challenging disease. Clinicians are faced with the need to exclude alternative diagnoses, limited treatment and management guidelines, and few treatment options. Patients with IPF have significantly increased healthcare usage compared with similar patients without the disease. Medicare estimates for this disease are as high as $3 billion, not including cost of treatment. The disease, characterized by worsening dyspnea, declining lung function, nonspecific respiratory symptoms, and a varied clinical course randomly punctuated by episodes of acute exacerbations, is also accompanied by a host of comorbid conditions that contribute significantly to increased healthcare usage and cost...
July 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28976944/the-new-news-about-lithium-an-underutilized-treatment-in-the-united-states
#19
Robert M Post
Lithium use for the treatment of mood disorders remains quite low, particularly in the United States compared to some European countries. Mogens Schou pioneered the study of lithium for prophylaxis of the recurrent mood disorder and encouraged its greater use. In an effort to further address the appropriate role of this drug, the multiple assets of lithium beyond its well-know anti-manic effect are reviewed, and a brief summary of its side effects is outlined. It appears that lithium has positive effects in depression and suicide prevention, cognition, and reducing the incidence of dementia...
October 4, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28976215/mania-following-antidepressant-discontinuation-in-depression-two-case-reports
#20
Cecilia Sze Nga Kwok, Leslie Eng Choon Lim
OBJECTIVE: Antidepressant-induced mania and an antidepressant discontinuation syndrome are well documented, whereas mania occurring after antidepressant cessation has been infrequently reported. METHOD: We describe antidepressant discontinuation-related mania in two Chinese patients, as well as a review of the literature on this phenomenon in unipolar depression. RESULTS: A 72-year-old man and a 65-year-old woman had late-onset depression with vascular risk factors, but no personal or family history of mood disorders...
September 1, 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
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