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https://www.readbyqxmd.com/read/28648642/hpi-amf-inhibition-halts-the-development-of-the-aggressive-phenotype-of-breast-cancer-stem-cells
#1
Juan Carlos Gallardo-Pérez, Alhelí Adán-Ladrón de Guevara, Alvaro Marín-Hernández, Rafael Moreno-Sánchez, Sara Rodríguez-Enríquez
Cancer stem cells are responsible for tumor recurrence and metastasis. A new highly reproducible procedure for human breast cancer MCF-7 stem cells (BCSC) isolation and selection was developed by using a combination of hypoxia/hypoglycemia plus taxol and adriamycin for 24h. The BCSC enriched fraction (i) expressed (2-15 times) the typical stemness protein markers CD44+, ALDH1A3 and Oct 3/4; (ii) increased its clonogenicity index (20-times), invasiveness profile (>70%), migration capacity (100%) and ability to form mammospheres, compared to its non-metastatic MCF-7 counterpart...
June 22, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28647744/effectiveness-of-supported-self-help-in-recurrent-depression-a-randomized-controlled-trial-in-primary-care
#2
Karolien E M Biesheuvel-Leliefeld, Sandra M A Dijkstra-Kersten, Digna J F van Schaik, Harm W J van Marwijk, Filip Smit, Henriette E van der Horst, Claudi L H Bockting
BACKGROUND: The burden and economic consequences of depression are high, mostly due to its recurrent nature. Due to current budget and time restraints, a preventive, low- cost, accessible minimal intervention is much needed. In this study, we evaluated the effectiveness of a supported self-help preventive cognitive therapy (S-PCT) added to treatment as usual (TAU) in primary care, compared to TAU alone. METHODS: We conducted a randomized controlled trial among 248 patients with a history of depression, currently in full or partial remission or recovery...
June 24, 2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28647678/methyl-jasmonate-attenuated-lipopolysaccharide-induced-depressive-like-behaviour-in-mice
#3
Adaeze Adebesin, Olusegun A Adeoluwa, Anthony T Eduviere, Solomon Umukoro
Depression is a recurrent neuropsychiatric disorder that affects millions of individuals worldwide and impact negatively on the patients' social functions and quality of life. Studies have shown that i.p injection of lipopolysaccharide (LPS) induces depressive-like behavior in rodents via induction of oxidative stress and neuroinflammation. Methyl jasmonate (MJ), an isolated compound from jasmine plant has gained reputation in aromatherapy for treatment of depression, nervousness and memory deficits. This study was designed to evaluate the effects of MJ on LPS-induced depressive-like behavior in mice...
June 19, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28645967/the-bipolar-illness-onset-study-research-protocol-for-the-bio-cohort-study
#4
Lars Vedel Kessing, Klaus Munkholm, Maria Faurholt-Jepsen, Kamilla Woznica Miskowiak, Lars Bo Nielsen, Ruth Frikke-Schmidt, Claus Ekstrøm, Ole Winther, Bente Klarlund Pedersen, Henrik Enghusen Poulsen, Roger S McIntyre, Flavio Kapczinski, Wagner F Gattaz, Jakob Bardram, Mads Frost, Oscar Mayora, Gitte Moos Knudsen, Mary Phillips, Maj Vinberg
INTRODUCTION: Bipolar disorder is an often disabling mental illness with a lifetime prevalence of 1%-2%, a high risk of recurrence of manic and depressive episodes, a lifelong elevated risk of suicide and a substantial heritability. The course of illness is frequently characterised by progressive shortening of interepisode intervals with each recurrence and increasing cognitive dysfunction in a subset of individuals with this condition. Clinically, diagnostic boundaries between bipolar disorder and other psychiatric disorders such as unipolar depression are unclear although pharmacological and psychological treatment strategies differ substantially...
June 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28645799/genotype-phenotype-evaluation-of-med13l-defects-in-the-light-of-a-novel-truncating-and-a-recurrent-missense-mutation
#5
Reza Asadollahi, Markus Zweier, Laura Gogoll, Raphael Schiffmann, Heinrich Sticht, Katharina Steindl, Anita Rauch
A decade after the designation of MED13L as a gene and its link to intellectual disability (ID) and dextro-looped transposition of great arteries in 2003, we previously described a recognizable syndrome due to MED13L haploinsufficiency. Subsequent reports of 22 further patients diagnosed by genome-wide testing further delineated the syndrome with expansion of the phenotypic spectrum and showed reduced penetrance for congenital heart defects. We now report two novel patients identified by whole exome sequencing, one with a de novo MED13L truncating mutation and the other with a de novo missense mutation...
June 20, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28644824/mechanism-underlying-acupuncture-ameliorated-depressive-behaviors-by-enhancing-glial-glutamate-transporter-in-chronic-unpredictable-mild-stress-cums-rats
#6
Ding Luo, Rui Ma, Yanan Wu, Xuechun Zhang, Yue Liu, Lin Wang, Wenbin Fu
BACKGROUND Major depressive disorder (MDD) is a recurrent mental illness worldwide. The glutamatergic neurotransmission system is now a target for antidepressant therapy because it takes part in synaptic plasticity and cognition in physical condition and has a potential excitatory neurotoxicity in pathological conditions. Glial glutamate transporter EAAT2 performs 90% of Glu neurotransmission. Therefore, the aim of the study was to evaluate the effect of acupuncture on depressive behaviors and EAAT2 in CUMS...
June 23, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28643193/assessing-cancer-specific-anxiety-in-chinese-men-with-prostate-cancer-psychometric-evaluation-of-the-chinese-version-of-the-memorial-anxiety-scale-for-prostate-cancer-max-pc
#7
Qingmei Huang, Ping Jiang, Zijun Zhang, Jie Luo, Yun Dai, Li Zheng, Wei Wang
PURPOSE: The Memorial Anxiety Scale for Prostate Cancer (MAX-PC) was developed to identify and assess cancer-specific anxiety among men with prostate cancer (PCa); however, there is no Chinese version. The aim of our study was to translate the English version of MAX-PC into Chinese and evaluate the psychometric properties of it. METHODS: The study cohort comprised 254 participants. Internal consistency including the Cronbach's alpha coefficient and item-total correlations were used to measure the reliability of the scale...
June 22, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28639819/effects-of-caregiving-status-and-changes-in-depressive-symptoms-on-development-of-physical-morbidity-among-long-term-cancer-caregivers
#8
Kelly M Shaffer, Youngmee Kim, Charles S Carver, Rachel S Cannady
OBJECTIVE: Cancer caregiving burden is known to vary across the survivorship trajectory and has been linked with caregivers' subsequent health impairment. Little is known, however, regarding how risk factors during long-term survivorship relate to vulnerability to caregivers' health during that period. This study examined effects of caregiving status and depressive symptoms on development of physical morbidity by 5 years postdiagnosis. METHOD: Family caregivers (N = 491; Mage = 55...
June 22, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/28639042/comparative-study-between-endoscopic-submucosal-dissection-and-surgery-in-patients-with-early-gastric-cancer
#9
Kyu Yeon Hahn, Chan Hyuk Park, Yong Kang Lee, Hyunsoo Chung, Jun Chul Park, Sung Kwan Shin, Yong Chan Lee, Hyoung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Sung Hoon Noh, Sang Kil Lee
BACKGROUND: Endoscopic submucosal dissection (ESD) is accepted as a standard treatment in patients with early gastric cancer (EGC) who have a negligible risk of lymph node metastasis. The aim of this study was to compare the short-term and long-term outcomes between ESD and surgery in patients with EGC that fulfilled the expanded indication of ESD on their final pathologic report. METHODS: We reviewed the clinical data of patients who underwent gastric ESD and surgery between January 2007 and December 2012...
June 21, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28637048/use-of-light-therapy-by-office-based-physicians
#10
Edda Winkler-Pjrek, Marie Spies, Pia Baldinger-Melich, Lisa Perkmann, Siegfried Kasper, Dietmar Winkler
BACKGROUND: Light therapy (LT) is a non-pharmacological biological treatment that has been used in psychiatry since the 1980s. Previous research has investigated the usage of LT in hospitals. The aim of this study was to examine the pattern of use of LT by office-based physicians. METHODS: A questionnaire was sent by mail to 400 randomly selected doctors in Austria. We made sure that the sample was equally representative of general practitioners (GPs) and psychiatrists, public health service doctors and private doctors, physicians in cities and in the country as well as male and female doctors...
June 22, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/28636578/human-neuropsin-gene-in-depression
#11
Kinga Bobińska, Joanna Mossakowska-Wójcik, Janusz Szemraj, Piotr Gałecki, Marlena Zajączkowska, Monika Talarowska
BACKGROUND: Neuropsin (NP, kallikrein 8, KLK8) - a kallikrein gene-related (KLK) endoprotease - plays a key role in neuroplasticity processes, since intracellular signal cascades and regulation of gene expression are engaged in long-term synaptic plasticity. The main aim of this paper is to compare expression of the human neuropsin gene on the mRNA level in a group of patients diagnosed with depression and in a group of healthy subjects who have never been treated psychiatrically. SUBJECTS AND METHODS: 291 people, aged 18-67, were qualified to participate in the experiment: major recurrent depression group (MRD) and the control group (CG)...
June 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28631695/-chronic-stress-and-mental-disorders-in-patients-with-systemic-scleroderma-results-of-an-interdisciplinary-study
#12
O F Seravina, T A Lisitsyna, M N Starovoytova, O V Desinova, O B Kovalevskaya, D Yu Veltishchev
AIM: To analyze of the prevalence of stressful factors and mental disorders (MDs), as well as their clinical psychopathological and clinical psychological characteristics to improve the comprehensive diagnosis and treatment of systemic scleroderma (SSD). SUBJECTS AND METHODS: Examinations were performed in 110 patients (predominantly women (n=97 (88.2%); mean age, 49.9±2.47 years) with a documented diagnosis of SSD (its mean duration, 7.25±0.42 years). 62 (56...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28630456/rare-disruptive-variants-in-the-disc1-interactome-and-regulome-association-with-cognitive-ability-and-schizophrenia
#13
S Teng, P A Thomson, S McCarthy, M Kramer, S Muller, J Lihm, S Morris, D C Soares, W Hennah, S Harris, L M Camargo, V Malkov, A M McIntosh, J K Millar, D H Blackwood, K L Evans, I J Deary, D J Porteous, W R McCombie
Schizophrenia (SCZ), bipolar disorder (BD) and recurrent major depressive disorder (rMDD) are common psychiatric illnesses. All have been associated with lower cognitive ability, and show evidence of genetic overlap and substantial evidence of pleiotropy with cognitive function and neuroticism. Disrupted in schizophrenia 1 (DISC1) protein directly interacts with a large set of proteins (DISC1 Interactome) that are involved in brain development and signaling. Modulation of DISC1 expression alters the expression of a circumscribed set of genes (DISC1 Regulome) that are also implicated in brain biology and disorder...
June 20, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28629232/latent-profile-analysis-of-the-five-facet-mindfulness-questionnaire-in-a-sample-with-a-history-of-recurrent-depression
#14
Jenny Gu, Anke Karl, Ruth Baer, Clara Strauss, Thorsten Barnhofer, Catherine Crane
BACKGROUND: Extending previous research, we applied latent profile analysis in a sample of adults with a history of recurrent depression to identify subgroups with distinct response profiles on the Five Facet Mindfulness Questionnaire and understand how these relate to psychological functioning. METHOD: The sample was randomly divided into two subsamples to first examine the optimal number of latent profiles (test sample; n = 343) and then validate the identified solution (validation sample; n = 340)...
June 1, 2017: Assessment
https://www.readbyqxmd.com/read/28628762/white-matter-microstructure-in-boys-with-persistent-depressive-disorder
#15
Veronika Vilgis, Alasdair Vance, Ross Cunnington, Timothy J Silk
BACKGROUND: Persistent depressive symptoms in children and adolescents are considered a risk factor for the development of major depressive disorder (MDD) later in life. Previous research has shown alterations in white matter microstructure in pediatric MDD but discrepancies exist as to the specific tracts affected. The current study aimed to improve upon previous methodology and address the question whether previous findings of lower fractional anisotropy (FA) replicate in a sample of children with persistent depressive disorder characterized by mild but more chronic symptoms of depression...
June 13, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28623894/-doing-the-right-thing-factors-influencing-gp-prescribing-of-antidepressants-and-prescribed-doses
#16
Chris F Johnson, Brian Williams, Stephen A MacGillivray, Nadine J Dougall, Margaret Maxwell
BACKGROUND: Antidepressant prescribing continues to increase, with 5-16% of adults receiving antidepressants annually. Total prescribing growth is due in part to increased long-term use, greater selective serotonin re-uptake inhibitor (SSRI) use and the use of higher SSRI doses. Evidence does not support routine use of higher SSRI doses for depression treatment, and factors influencing the use of such doses are not well known. The aim of this study was to explore factors influencing GPs' use of antidepressants and their doses to treat depression...
June 17, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28618857/state-independent-and-dependent-neural-responses-to-psychosocial-stress-in-current-and-remitted-depression
#17
Qingsen Ming, Xue Zhong, Xiaocui Zhang, Weidan Pu, Daifeng Dong, Yali Jiang, Yidian Gao, Xiang Wang, John A Detre, Shuqiao Yao, Hengyi Rao
OBJECTIVE: Stress is a strong risk factor for major depressive disorder, while sensitization to stress in remitted individuals plays a key role in depression recurrence. The present study explored the state-independent (trait) and dependent (state) neural responses to psychosocial stress in major depressive disorder. METHOD: Thirty-six patients with medication-naive first-episode current depression, 33 patients with remitted depression, and 36 demographically matched healthy control participants were administered the Montreal Imaging Stress Task during functional MRI...
June 16, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28615770/the-mood-spectrum-and-temperamental-instability-in-unipolar-and-bipolar-disorder
#18
Manish Kumar, Pradeep Kumar Saha, Anwesha Mondal
BACKGROUND: The current categorical split of mood disorders in bipolar (BP) disorders and depressive disorders has recently been questioned. The presence of a significant number of manic/hypomanic symptoms in patients with recurrent unipolar depression seems to challenge the traditional dichotomy of unipolar-BP disorder. Two highly unstable personality features, i.e., the cyclothymic temperament (CT) and borderline personality disorder, have been found to be more common in BP disorder than in major depressive disorder...
May 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28615767/do-life-events-and-social-support-vary-across-depressive-disorders
#19
Savitha Soman, Shripathy M Bhat, K S Latha, Samir Kumar Praharaj
BACKGROUND: Social support and life events moderate the expression of depression though studies have shown contradictory results. The objective was to study the stressful life events and perceived social support in patients with adjustment disorder, first-episode depression, and recurrent depressive disorder (RDD). SUBJECTS AND METHODS: One hundred and forty-six patients aged 18-60 years with adjustment disorder, first-episode depression, or RDD according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision were evaluated using the presumptive stressful life events scale and Multidimensional Scale of Perceived Social Support...
May 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28613090/personality-disorders-in-primary-care-impact-on-depression-outcomes-within-collaborative-care
#20
Kurt B Angstman, Ashok Seshadri, Alberto Marcelin, Cesar A Gonzalez, Gregory M Garrison, Jay-Sheree Allen
BACKGROUND: Individuals with personality disorders (PDs) are high utilizers of primary care and mental health services; however, they struggle to utilize the care effectively and studies have shown a strong association between having a PD and higher impairment in social role functioning. This is especially important because PDs are highly comorbid with a wide range of other mental health disorders. The collaborative care model (CCM) for depression was developed with an emphasis on patient engagement and aimed to reduce health care utilization, while improving treatment outcomes in primary care...
June 1, 2017: Journal of Primary Care & Community Health
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