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https://www.readbyqxmd.com/read/29351138/the-effect-of-melatonin-upon-postacute-withdrawal-among-males-in-a-residential-treatment-program-m-paws-a-randomized-double-blind-placebo-controlled-trial
#1
Corry D Bondi, Khalid M Kamal, David A Johnson, Paula A Witt-Enderby, Vincent J Giannetti
OBJECTIVE: Assess the effect of melatonin (5 mg) compared with placebo as an adjuvant treatment along with current behavioral and pharmacotherapy for 28 days on weekly self-reported severity of anxiety, depression, stress, and sleep complaints, and also how sleep is affecting daily life in males 18 years of age and older in recovery from substance use at a residential program in south-western Pennsylvania. BACKGROUND: Individuals in recovery experience a variety of symptoms including, but are not limited to, anxiety, depression, sleep difficulties, and stress...
January 18, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29347869/social-support-networks-and-quality-of-life-of-rural-men-in-a-context-of-marriage-squeeze-in-china
#2
Sasa Wang, Xueyan Yang, Isabelle Attané
A significant number of rural Chinese men are facing difficulties in finding a spouse and may fail to ever marry due to a relative scarcity of women in the adult population. Research has indicated that marriage squeeze is a stressful event which is harmful to men's quality of life, and also weakens their social support networks. Using data collected in rural Chaohu city, Anhui, China, this study explores the effects of social support networks on quality of life of rural men who experience a marriage squeeze...
January 1, 2018: American Journal of Men's Health
https://www.readbyqxmd.com/read/29343476/role-of-macrophage-socs3-in-the-pathogenesis-of-aortic-dissection
#3
Satoko Ohno-Urabe, Hiroki Aoki, Michihide Nishihara, Aya Furusho, Saki Hirakata, Norifumi Nishida, Sohei Ito, Makiko Hayashi, Hideo Yasukawa, Tsutomu Imaizumi, Hidetoshi Akashi, Hiroyuki Tanaka, Yoshihiro Fukumoto
BACKGROUND: Aortic dissection (AD) is a life-threatening medical emergency caused by the abrupt destruction of the intimomedial layer of the aortic walls. Given that previous studies have reported the involvement of proinflammatory cytokine interleukin-6 in AD pathogenesis, we investigated the role of signal transduction and activator of transcription 3 signaling, a downstream pathway of interleukin-6 in macrophages in pathogenesis of AD. METHODS AND RESULTS: We characterized the pathological and molecular events triggered by aortic stress, which can lead to AD...
January 17, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29339473/identification-of-thioredoxin-interacting-protein-txnip-as-a-downstream-target-for-igf1-action
#4
Karthik Nagaraj, Lena Lapkina-Gendler, Rive Sarfstein, David Gurwitz, Metsada Pasmanik-Chor, Zvi Laron, Shoshana Yakar, Haim Werner
Laron syndrome (LS), or primary growth hormone (GH) insensitivity, is the best-characterized entity among the congenital insulin-like growth factor 1 (IGF1) deficiencies. Life-long exposure to minute endogenous IGF1 levels is linked to low stature as well as a number of endocrine and metabolic abnormalities. While elevated IGF1 is correlated with increased cancer incidence, epidemiological studies revealed that patients with LS do not develop tumors. The mechanisms associated with cancer protection in LS are yet to be discovered...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29338753/examining-within-and-across-day-relationships-between-transient-and-chronic-stress-and-parent-food-related-parenting-practices-in-a-racially-ethnically-diverse-and-immigrant-population-stress-types-and-food-related-parenting-practices
#5
Jerica M Berge, Allan Tate, Amanda Trofholz, Angela Fertig, Scott Crow, Dianne Neumark-Sztainer, Michael Miner
BACKGROUND: Although prior research suggests that stress may play a role in parent's use of food-related parenting practices, it is unclear whether certain types of stress (e.g., transient, chronic) result in different food-related parenting practices. Identifying whether and how transient (i.e., momentary; parent/child conflict) and chronic (i.e., long-term; unemployment >6 months) sources of stress are related to parent food-related parenting practices is important with regard to childhood obesity...
January 16, 2018: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/29338677/vitamin-b-6-and-depressive-symptomatology-over-time-in-older-latino-adults
#6
Sandra P Arévalo, Tammy M Scott, Luis M Falcón, Katherine L Tucker
BACKGROUND: Low vitamin B-6 status has been linked to depressive symptomatology. We examined the longitudinal association of vitamin B-6 status with depressive symptomatology across 3-time points over ∼5-7 years in a cohort of older Hispanic adults. METHODS: We used two-level hierarchical linear regression models for continuous outcomes. Vitamin B-6 status was associated with depressive symptomatology across these time points. RESULTS: Plasma pyridoxyl-5-phosphate (PLP) concentration, a time-varying predictor, was significantly associated with depressive symptomatology...
January 16, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29338344/reappraisal-inventiveness-impact-of-appropriate-brain-activation-during-efforts-to-generate-alternative-appraisals-on-the-perception-of-chronic-stress-in-women
#7
Corinna M Perchtold, Andreas Fink, Christian Rominger, Hannelore Weber, Vera Loureiro de Assunção, Günter Schulter, Elisabeth M Weiss, Ilona Papousek
BACKGROUND AND OBJECTIVES: Previous research indicated that more left-lateralized prefrontal activation during cognitive reappraisal efforts was linked to a greater capacity for generating reappraisals, which is a prerequisite for the effective implementation of cognitive reappraisal in everyday life. The present study examined whether the supposedly appropriate brain activation is relevant in terms of more distal outcomes, i.e., chronic stress perception. DESIGN AND METHODS: Prefrontal EEG alpha asymmetry was recorded while female participants were generating reappraisals for stressful events and was correlated with their self-reported chronic stress levels in everyday life (n = 80)...
January 16, 2018: Anxiety, Stress, and Coping
https://www.readbyqxmd.com/read/29334658/contextual-determinants-of-psychopathology-the-singularity-of-attachment-as-a-predictor-of-mental-dysfunction
#8
Yolanda Alonso, Javier Fernández, Yolanda Fontanil, Esteban Ezama, Alberto Gimeno
The general aim of this research is to evaluate the singular weight of attachment relationships in psychopathology, to determine the point to which these relationships cannot be subsumed by other variables that are famously related to attachment, such as experience of stressful life events, social support, and coping styles. 172 people treated in mental health centers provided data related to these four aspects and about manifestations of psychopathology. Multiple linear regression analyses determined that 51% of the variance in the level of symptomatology is explained with six variables: two related to adult attachment (fear of rejection and abandonment in romantic relationships, and the degree of similarity to the fearful prototype), one related to social support (family appreciation), one to life events (overall perceived stress), and two to coping style (cognitive restructuring and social withdrawal)...
January 9, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29334643/longitudinal-determinants-of-depression-among-world-trade-center-health-registry-enrollees-14-15-years-after-the-9-11-attacks
#9
Melanie H Jacobson, Christina Norman, Angela Nguyen, Robert M Brackbill
BACKGROUND: Exposure to the September 11, 2001 (9/11) terrorist attacks has been found to be associated with posttraumatic stress disorder (PTSD) and comorbid PTSD and depression up to 10-11 years post-disaster. However, little is known about the longitudinal predictors of mental health conditions over time. METHODS: We examined longitudinal determinants of depression within strata of PTSD among 21,258 enrollees of the World Trade Center Health Registry who completed four questionnaires over 14 years of follow-up (Wave 1 in 2003-04; Wave 2 in 2005-06; Wave 3 in 2011-12; and Wave 4 in 2015-16)...
January 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29331823/pre-pregnancy-maternal-depressive-symptoms-and-low-birth-weight-and-preterm-birth-outcomes-assessment-of-adolescent-background-characteristics-and-birth-outcomes-in-adulthood
#10
Stephen Nkansah-Amankra
PURPOSE: In the United States and other countries of the world , high prevalence of pre-pregnancy depressive symptoms and depression during pregnancy is an important public health concern, as they are associated with low birth weight (LBW) and preterm birth (PTB) outcomes in adulthood. However, the relationships among pre-pregnancy depressive symptoms, low birth weight, preterm birth outcomes and household characteristics have not been well established. METHODS: The study used data from 7120 adolescent female participants in the National Longitudinal Study of Adolescent to Adult Health data from Waves I (1994-1995 in-school interview), II (1996 as in-home), III (2001-2002 as in-home interview), IV (2008 as in-home interview) and Wave V is currently underway...
December 13, 2017: Midwifery
https://www.readbyqxmd.com/read/29331801/stressful-life-events-relationship-stressors-and-cortisol-reactivity-the-moderating-role-of-suppression
#11
Lydia G Roos, Sara M Levens, Jeanette M Bennett
Stressful life events (SLEs) are exceedingly common and have been associated with a range of psychological disorders, perhaps through dysregulation in the hypothalamic-pituitary-adrenal (HPA) axis. The use of certain emotion regulation strategies in response to stress, such as expressive suppression and cognitive reappraisal, has additionally been linked to heightened HPA axis reactivity to acute stress. However, it is unclear how emotion regulation may interact with SLEs to affect HPA axis reactivity, particularly concerning relationship stressors (RSs)...
January 2, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29328780/risk-factors-for-depression-an-autobiographical-review
#12
Constance Hammen
I have been given a priceless opportunity to reflect on my career in the remarkably productive field of risk factors for depression. Psychological research on depression exploded in the early years of my work. I try to give an account of the choices and challenges, and reflect on the influences, some calculated and some serendipitous, that determined the paths I have followed. I focus mostly on the robust depression risk factors that have influenced my research, including dysfunctional cognitions, stressful life events and circumstances, parental depression, interpersonal dysfunction, and being female, and I cover some of what I did but also the influential work of others...
January 12, 2018: Annual Review of Clinical Psychology
https://www.readbyqxmd.com/read/29327258/mental-health-problems-of-syrian-refugee-children-the-role-of-parental-factors
#13
Seyda Eruyar, John Maltby, Panos Vostanis
War-torn children are particularly vulnerable through direct trauma exposure as well through their parents' responses. This study thus investigated the association between trauma exposure and children's mental health, and the contribution of parent-related factors in this association. A cross-sectional study with 263 Syrian refugee children-parent dyads was conducted in Turkey. The Stressful Life Events Questionnaire (SLE), General Health Questionnaire, Parenting Stress Inventory (PSI-SF), Impact of Events Scale for Children (CRIES-8), and Strengths and Difficulties Questionnaire were used to measure trauma exposure, parental psychopathology, parenting-related stress, children's post-traumatic stress symptoms (PTSS), and mental health problems, respectively...
January 11, 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29324301/depression-and-fatigue-in-multiple-sclerosis-relation-to-exposure-to-violence-and-cerebrospinal-fluid-immunomarkers
#14
Philip Brenner, Mathias Granqvist, Johan Königsson, Faiez Al Nimer, Fredrik Piehl, Jussi Jokinen
Multiple sclerosis (MS) is a neuroinflammatory condition characterized by chronic dysregulation of immune responses leading to repeated episodes of inflammation in the central nervous system. Depression and fatigue are common among MS patients, even in early disease phases, and the disease course can be negatively affected by stressful events. IL-6 and IL-8 have been associated with depression and stressful life events in non-MS patients. The aim of this study was to examine the relationships between depression, fatigue, and exposure to violence, with IL-6 and IL-8 levels in the cerebrospinal fluid (CSF) of MS patients...
January 4, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29323526/psychological-and-neural-correlates-of-embitterment-in-old-age
#15
Simone Kühn, Sandra Düzel, Johanna Drewelies, Denis Gerstorf, Ulman Lindenberger, Jürgen Gallinat
OBJECTIVE: Posttraumatic embitterment disorder (PTED) comprises a stress-related response to a negative life event that violates the belief system of the individual. Characteristic symptoms involve repeated intrusive thoughts, emotional arousal when reminded of the event, and decreases in well-being. METHOD: Within the scope of the present study, embitterment was treated as a continuous rather than categorical concept, and we investigated its psychological and brain structural correlates in a sample of healthy older adults...
January 2018: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/29323523/trauma-across-generations-and-paths-to-adaptation-and-resilience
#16
Amy Lehrner, Rachel Yehuda
OBJECTIVE: There is a growing literature on the intergenerational transmission of trauma, representing approaches across psychodynamic, family systems, epidemiological, sociological, and biological levels of analysis. Embitterment has been proposed as a response to severe, but normative, stressful events, different from the life-threatening trauma that precedes posttraumatic stress disorder (PTSD). METHOD: This article reviews the potential applicability of the construct of embitterment to trauma and intergenerational effects through (a) a historical review of the intergenerational transmission of trauma literature, (b) a discussion of embitterment versus PTSD, (c) a brief review of theories of mechanisms of transmission, and (d) a discussion of biological findings and their interpretation...
January 2018: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/29323522/demoralization-and-embitterment
#17
Maria Giulia Nanni, Rosangela Caruso, Silvana Sabato, Luigi Grassi
OBJECTIVE: Individuals may experience a wide range of psychological reactions in response to negative life events. Even if events that threaten life have been always played a central role in research, recent studies have outlined that experiences, considered exceptional but part of the human existence (e.g., divorce, unemployment, or chronic illness) may also lead individuals to experience enduring emotional states of suffering. Demoralization has been substantially described as an important condition occurring in response to stressful events, while a recent interest is growing on embitterment as a common reaction...
January 2018: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/29322164/efficacy-of-transdermal-estradiol-and-micronized-progesterone-in-the-prevention-of-depressive-symptoms-in-the-menopause-transition-a-randomized-clinical-trial
#18
Jennifer L Gordon, David R Rubinow, Tory A Eisenlohr-Moul, Kai Xia, Peter J Schmidt, Susan S Girdler
Importance: The menopause transition and early postmenopausal period are associated with a 2- to 4-fold increased risk for clinically significant depressive symptoms. Although a few studies suggest that hormone therapy can effectively manage existing depression during this time, to our knowledge, there have been no studies testing whether hormone therapy can prevent the onset of perimenopausal and early postmenopausal depressive symptoms. Objective: To examine the efficacy of transdermal estradiol plus intermittent micronized progesterone (TE+IMP) in preventing depressive symptom onset among initially euthymic perimenopausal and early postmenopausal women...
January 10, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29317594/polymorphism-in-tmem132d-regulates-expression-and-anxiety-related-behavior-through-binding-of-rna-polymerase-ii-complex
#19
Roshan R Naik, Sergey V Sotnikov, Rebekka P Diepold, Stella Iurato, Patrick O Markt, Andrea Bultmann, Nadine Brehm, Tobias Mattheus, Beat Lutz, Angelika Erhardt, Elisabeth B Binder, Ulrike Schmidt, Florian Holsboer, Rainer Landgraf, Ludwig Czibere
TMEM132D is a candidate gene, where risk genotypes have been associated with anxiety severity along with higher mRNA expression in the frontal cortex of panic disorder patients. Concurrently, in a high (HAB) and low (LAB) trait anxiety mouse model, Tmem132d was found to show increased expression in the anterior cingulate cortex (aCC) of HAB as compared to LAB mice. To understand the molecular underpinnings underlying the differential expression, we sequenced the gene and found two single-nucleotide polymorphisms (SNPs) in the promoter differing between both lines which could explain the observed mRNA expression profiles using gene reporter assays...
January 10, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29314412/coping-thought-suppression-and-perceived-stress-in-currently-depressed-previously-depressed-and-never-depressed-individuals
#20
Jens C Thimm, Catharina E A Wang, Knut Waterloo, Martin Eisemann, Marianne Halvorsen
BACKGROUND: Previous research shows that depression is associated with an increase in stressful life events and perceived stress as well as dysfunctional ways of coping with stress. However, knowledge about coping in previously depressed individuals is scant. METHODS: This study compared perceived stress, coping, and thought suppression in a sample of 30 currently depressed, 63 previously depressed, and 42 never depressed individuals. RESULTS: Analysis of variance revealed that previously depressed individuals showed less wishful thinking and thought suppression than the currently depressed individuals, but scored significantly higher on these strategies than the never depressed individuals...
January 4, 2018: Clinical Psychology & Psychotherapy
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