keyword
MENU ▼
Read by QxMD icon Read
search

recurrent

keyword
https://www.readbyqxmd.com/read/29929183/pre-clinical-evaluation-of-novel-mucoadhesive-bilayer-patches-for-local-delivery-of-clobetasol-17-propionate-to-the-oral-mucosa
#1
H E Colley, Z Said, M E Santocildes-Romero, S R Baker, K D'Apice, J Hansen, L Siim Madsen, M H Thornhill, P V Hatton, C Murdoch
Oral lichen planus (OLP) and recurrent aphthous stomatitis (RAS) are chronic inflammatory conditions often characterised by erosive and/or painful oral lesions that have a considerable impact on quality of life. Current treatment often necessitates the use of steroids in the form of mouthwashes, creams or ointments, but these are often ineffective due to inadequate drug contact times with the lesion. Here we evaluate the performance of novel mucoadhesive patches for targeted drug delivery. Electrospun polymeric mucoadhesive patches were produced and characterised for their physical properties and cytotoxicity before evaluation of residence time and acceptability in a human feasibility study...
June 14, 2018: Biomaterials
https://www.readbyqxmd.com/read/29929138/prothrombotic-mechanisms-in-patients-with-congenital-p-cys89tyr-mutation-in-cd59
#2
Adi Tabib, Issam Hindi, Netanel Karbian, Orly Zelig, Batla Falach, Dror Mevorach
BACKGROUND: Thrombosis is the prognostic factor with the greatest effect on survival in patients with paroxysmal nocturnal hemoglobinuria (PNH), who lack dozens of membrane surface proteins. We recently described a primary homozygous Cys89Tyr congenital nonfunctioning CD59 in humans with clinical manifestation in infancy, associated with chronic hemolysis, recurrent strokes, and relapsing peripheral demyelinating neuropathy. Here we investigated hypercoagulability mechanisms characterizing the syndrome...
June 11, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29929092/adjuvant-chemotherapy-and-postoperative-radiotherapy-in-high-risk-soft-tissue-sarcoma-patients-defined-by-biological-risk-factors-a-scandinavian-sarcoma-group-study-ssg-xx
#3
Kirsten Sundby Hall, Øyvind S Bruland, Bodil Bjerkehagen, Olga Zaikova, Jacob Engellau, Oskar Hagberg, Lina Hansson, Hans Hagberg, Marie Ahlström, Heidi Knobel, Karin Papworth, Maja Zemmler, Dorota Goplen, Henrik C F Bauer, Mikael Eriksson
PURPOSE: To investigate the outcome following adjuvant doxorubicin and ifosfamide in a prospective non-randomised study based on a soft tissue sarcoma (STS) patient subgroup defined by specific morphological characteristics previously shown to be at a high-risk of metastatic relapse. The expected 5-year cumulative incidence of metastases in patients with this risk profile has previously been reported to be about 50% without adjuvant chemotherapy. METHODS: High-risk STS was defined as high-grade morphology (according to the Fédération Nationale des Centres de Lutte Contre le Cancer [FNCLCC] grade II-III) and either vascular invasion or at least two of the following criteria: tumour size ≥8...
June 18, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29929034/craniotomy-for-a-large-and-aggressive-de-novo-cavernous-malformation-resection-in-the-basal-ganglia-region
#4
Zhiyong Yan, Shusheng Che, Yingbin Jiao, JianPeng Wang, Xingze Li, Chao Wang
Cerebral cavernous malformations (CCMs) are present in up to 0.5% of the general population. While CCMs have been considered congenital lesions, numerous reports have observed de novo formations in patients with the familial form of CCM and in patients after cranial radiotherapy. Outside of these circumstances, there is scant evidence as to the potential etiologies of CCM. We present a 48-year-old woman with a medical history of endometrial hyperplasia concomitant endometrial polyps demonstrating a large de novo CCM, which grew to a large size in a period of 20 months...
June 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29929026/surgical-treatment-of-middle-cerebral-artery-aneurysms-the-aneurysm-location-and-size-ratio-as-risk-factors-for-the-neurological-worsening-and-ischemic-complications
#5
Hidetoshi Matsukawa, Hiroyasu Kamiyama, Takanori Miyazaki, Yu Kinoshita, Nakao Ota, Kosumo Noda, Takaharu Shonai, Osamu Takahashi, Sadahisa Tokuda, Rokuya Tanikawa
OBJECT: Regardless of acceptable surgical results of middle cerebral artery aneurysms (MCAs), MCA territory infarction (MCATI) is still one of major problems needing to be solved to archive the better outcome. Authors aimed to investigate the MCATI in patients with surgically treated MCA aneurysms. METHODS: The data of 286 consecutive patients with 322 MCA aneurysms was retrospectively evaluated. The aneurysm location was classified into the early frontal cortical branch (EFCB), early temporal cortical branch (ETCB), bi- or trifurcation (M1-2), and distal aneurysms on the insular, opercular, or cortical segments of MCA (distal MCA)...
June 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29929016/intralesional-steroid-injections-for-recurrent-vaginal-strictures
#6
Jessica Shim, Maggie Dwiggins, Veronica Gomez-Lobo
BACKGROUND: Postoperative complications after transverse vaginal septum excision include stricture formation. The purpose of this report is to describe use of intralesional corticosteroid injections for vaginal strictures. CASE: A 32-year-old gravida-0 with history of transverse vaginal septum and recurrent strictures presented for follow-up of chronic pelvic pain. After her fourth septum revision, the patient underwent a total of seven triamcinolone injections at the septum tissue...
June 18, 2018: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29929015/free-antero-lateral-thigh-flap-for-total-knee-prosthesis-coverage-after-infection-complicating-malignant-tumour-resection
#7
Cécile Philandrianos, Jean-Camille Mattei, Alexandre Rochwerger, Baptiste Bertrand, Charlotte Jaloux, Dominique Casanova
BACKGROUND: Infection is a common complication of major lower limb-sparing surgery with massive total knee prosthesis (MTKP) reconstruction after extensive tumour resection. When free tissue transfer is required to cover the prosthesis, musculo-cutaneous flaps are usually preferred based on proven efficacy when used in both one-stage and two-stage procedures. The use of a free fascio-cutaneous antero-lateral thigh (FC-ALT) flap in 3 patients with infected knee reconstructions is reported here...
June 18, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29928946/long-term-impact-of-regional-nodal-irradiation-in-patients-with-node-positive-breast-cancer-treated-with-neoadjuvant-systemic-therapy
#8
Shane R Stecklein, Minjeong Park, Diane D Liu, Janeiro J Valle Goffin, Abigail S Caudle, Elizabeth A Mittendorf, Carlos H Barcenas, Sarah Mougalian, Wendy A Woodward, Vicente Valero, Aysegul A Sahin, Wei T Yang, Simona F Shaitelman
BACKGROUND: The impact of regional nodal irradiation (RNI) on locoregional recurrence (LRR) and any disease recurrence (DR) in women with node-positive breast cancer who receive neoadjuvant systemic therapy (NAT) is unknown. METHODS: The impact of RNI on LRR and DR was estimated with the cumulative incidence method in 1289 women with stage II-III breast cancer with cytologically confirmed axillary metastases who received NAT, 1989-2007. Multicovariate Cox regression analysis was performed to examine the effect of RNI after accounting for other predictive and prognostic variables...
June 18, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29928848/retrospective-evaluation-of-fidaxomicin-versus-oral-vancomycin-for-treatment-of-clostridium-difficile-infections-in-allogeneic-stem-cell-transplant
#9
Laura Prohaska, Zahra Mahmoudjafari, Leyla Shune, Anurag Singh, Tara Lin, Sunil Abhyankar, Siddhartha Ganguly, Dennis Grauer, Joseph McGuirk, Lisa Clough
OBJECTIVE/BACKGROUND: Clostridium difficile infection (CDI) is a potential complication during hematopoietic stem cell transplantation (HSCT), and no specific recommendations exist regarding treatment of CDI in allogeneic SCT patients. Use of metronidazole and oral vancomycin has been associated with clinical failure. Fidaxomicin has previously been found noninferior to the use of oral vancomycin for the treatment of CDI, and no studies have compared the use of oral vancomycin with fidaxomicin for the treatment of CDI in allogeneic SCT...
June 18, 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29928823/weaning-and-mixed-mania-a-case-report
#10
Verinder Sharma
INTRODUCTION: The development of mania during weaning is an underreported phenomenon that has received little attention in the recent past. Lack of timely diagnosis and effective management can negatively affect not only the mother but also her family. Main issue: I describe the case of a woman who experienced onset of mixed mania during weaning. At that time, she was diagnosed with bipolar I disorder, current episode manic, and a mixed-features specifier. The woman had a history of bipolar II disorder and a family history of postpartum depression and bipolar disorder...
June 1, 2018: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/29928701/adjuvant-chemoradiation-for-gastric-carcinoma-state-of-the-art-and-perspectives
#11
REVIEW
A Schernberg, E Rivin Del Campo, B Rousseau, O Matzinger, M Loi, P Maingon, F Huguet
An estimated 990,000 new cases of gastric cancer are diagnosed worldwide each year. Surgical excision, the only chance for prolonged survival, is feasible in about 20% of cases. Even after surgery, the median survival is limited to 12 to 20 months due to the frequency of locoregional and/or metastatic recurrences. This led to clinical trials associating surgery with neoadjuvant or adjuvant treatments to improve tumor control and patient survival. The most studied modalities are perioperative chemotherapy and adjuvant chemoradiotherapy...
March 2018: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29928624/can-a-diagnosis-of-bladder-cancer-motivate-positive-lifestyle-changes-and-prevent-recurrent-disease
#12
EDITORIAL
Caitlin Lim, John R Cohn, Joshua A Cohn
No abstract text is available yet for this article.
May 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29928615/the-impact-of-intra-operative-cell-salvage-during-open-radical-prostatectomy
#13
Ned Kinnear, Bridget Heijkoop, Lina Hua, Derek B Hennessey, Daniel Spernat
Background: To examine the effect of intra-operative cell salvage (ICS) in open radical prostatectomy. Methods: In this retrospective cohort study, all patients undergoing open radical prostatectomy for malignancy at our institution between 10/04/2013 and 10/04/2017 were enrolled. Patients were grouped and compared based on whether they received ICS. Primary outcomes were allogeneic transfusion rates, and disease recurrence. Secondary outcomes were complications and transfusion-related cost...
May 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29928612/huge-and-recurrent-undifferentiated-carcinoma-with-osteoclast-like-giant-cells-of-the-pancreas
#14
Lan Zhang, Jeong Min Lee, Jeong Hee Yoon, Ijin Joo, Hyo Jin Kang, Joon Koo Han, Sun Kyung Jeon
No abstract text is available yet for this article.
May 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29928502/high-molecular-weight-hyaluronic-acid-a-two-pronged-protectant-against-infection-of-the-urogenital-tract
#15
Catherine A Mowbray, Syema Shams, Git Chung, Anna Stanton, Phillip Aldridge, Andrejus Suchenko, Robert S Pickard, Ased Sm Ali, Judith Hall
Objectives: Recurrent urinary tract infections are associated with uropathogenic Escherichia coli (UPEC) ascending and infecting the urinary tract. Antibiotics provide only symptomatic relief, not prevent recurrence. Clinical evidence suggests that intravesical glycosaminoglycan therapy, such as hyaluronic acid (HA), helps reduce UTI recurrence. This has been investigated here using in vitro systems modelling the urogenital tract tissues. Methods: RT4 bladder cells were preconditioned with high molecular weight HA (> 1500 kDa) at 2 mg mL-1 and challenged with UPEC to analyse barrier protection and bacterial adherence...
2018: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/29928485/the-dynamics-of-her2-status-in-esophageal-adenocarcinoma
#16
Aafke Creemers, Eva A Ebbing, Gerrit K J Hooijer, Lisanne Stap, Rajni A Jibodh-Mulder, Susanne S Gisbertz, Mark I van Berge Henegouwen, Maurits L van Montfoort, Maarten C C M Hulshof, Kausilia K Krishnadath, Martijn G H van Oijen, Maarten F Bijlsma, Sybren L Meijer, Hanneke W M van Laarhoven
Trastuzumab, a monoclonal antibody against HER2, has become standard of care for metastatic HER2-overexpressing esophagogastric adenocarcinoma and is currently investigated as (neo)adjuvant treatment option in HER2-positive esophagogastric adenocarcinoma. The HER2 status is commonly determined on archived material of the primary tumor. However, this status may change over the course of treatment or disease progression. The aim of this study was to assess the dynamics of HER2 status in esophageal adenocarcinoma (EAC) in patients with resectable and recurrent disease, and to determine the associations of these changes with clinical outcome...
June 1, 2018: Oncotarget
https://www.readbyqxmd.com/read/29928441/the-upregulated-expression-of-vascular-endothelial-growth-factor-in-surgically-treated-patients-with-recurrent-radioresistant-cervical-cancer-of-the-uterus
#17
Kosuke Yoshida, Shiro Suzuki, Jun Sakata, Fumi Utsumi, Kaoru Niimi, Nobuhisa Yoshikawa, Kimihiro Nishino, Kiyosumi Shibata, Fumitaka Kikkawa, Hiroaki Kajiyama
Vascular endothelial growth factor (VEGF) inhibitors have been utilized for the treatment against advanced or recurrent cervical carcinoma as a novel therapeutic modality. However, the expression level of VEGF in post-radiotherapy relapsed/persistent cervical cancer remains to be elucidated. The aim of the present study was to investigate the expression of VEGF and associated molecules using tumor samples from patients with post-radiotherapy relapsed/persistent cervical cancer. From a database of 826 patients who were treated at our institution between 2003 and 2015, eight patients with post-radiotherapy relapsed/persistent cervical cancer were identified, and 20 patients who underwent initial surgery alone were used as a control...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928439/ovarian-cancer-initially-presenting-with-supra-clavicular-lymph-node-metastasis-a-case-report
#18
Lu Hong, Hui Qiu, Zijie Mei, Hui Zhang, Shaopin Liu, Hong Cao
Supra-clavicular lymph node metastasis from ovarian cancer is rare. The present study reports the unique case of a 43-years-old patient who initially presented with left supra-clavicular lymph node metastasis, and was nulliparous. According to fine-needle aspiration cytology of the metastatic left supra-clavicular lymph nodes and 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (PET/CT) scan, the patient was diagnosed with poorly differentiated serous carcinoma of ovarian cancer, stage IV...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928435/matrix-metalloproteinase-12-expression-is-associated-with-tumor-foxp3-regulatory-t-cell-infiltration-and-poor-prognosis-in-hepatocellular-carcinoma
#19
Min-Ke He, Yong Le, Yong-Fa Zhang, Han-Yue Ouyang, Pei-En Jian, Zi-Shan Yu, Li-Juan Wang, Ming Shi
Hepatocellular carcinoma (HCC) is among the most fatal types of cancer worldwide due to its high rates of recurrence and metastasis. The molecular processes involved in HCC progression require further investigation to identify biomarkers for use in diagnosis and treatment. In the present study, the significance and prognostic value of matrix metallopeptidase 12 (MMP12) expression in human HCC was investigated. MMP12 mRNA expression was investigated using reverse transcription-quantitative polymerase chain reaction analysis of 42 pairs of tumor and non-tumor liver tissues obtained from patients with HCC following surgical treatment...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928422/analyzing-egfr-mutations-and-their-association-with-clinicopathological-characteristics-and-prognosis-of-patients-with-lung-adenocarcinoma
#20
Xiuzhi Zhou, Li Cai, Junjie Liu, Xiaomin Hua, Ying Zhang, Huilin Zhao, Bin Wang, Boqing Li, Pengzhou Gai
Epidermal growth factor receptor (EGFR) is an important gene in the development of lung adenocarcinoma. However, there is controversy regarding the association between EGFR mutations and survival time of patients with lung adenocarcinoma. In the present study, tissue specimens and clinical data were collected from 219 patients with lung adenocarcinoma who had not undergone prior radiotherapy or chemotherapy. EGFR mutations were detected using a fluorescence polymerase chain reaction method, and the association between EGFR mutations and clinicopathological characteristics was analyzed...
July 2018: Oncology Letters
keyword
keyword
20601
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"