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https://www.readbyqxmd.com/read/29055260/swimming-exercise-reverses-cums-induced-changes-in-depression-like-behaviors-and-hippocampal-plasticity-related-proteins
#1
Weina Liu, Xiangli Xue, Jie Xia, Jiatong Liu, Zhengtang Qi
BACKGROUND: Stress-induced failed resilience of brain plasticity can contribute to the onset and recurrence of depression. Chronic stress has been reported to open windows of epigenetic plasticity in hippocampus. However, how hippocampal plasticity underlies depression-like behaviors and how it adapts in response to stress has not been addressed. The present study aimed to investigate the signaling mechanisms of CUMS affecting hippocampal plasticity-related proteins expression and the regulation of swimming exercise in mice...
October 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29055168/long-term-safety-of-growth-hormone-a-combined-registry-analysis
#2
Kirstine Stochholm, Wieland Kiess
OBJECTIVES: Preliminary data from the French cohort of the Safety and Appropriateness of Growth hormone treatments in Europe (SAGhE) study raised concerns regarding the safety of recombinant human GH, suggesting that GH may increase mortality and incidence of stroke in patients treated during childhood for GH deficiency or short stature. We evaluated published safety data, focusing on mortality, neoplasms, cerebrovascular events and diabetes across a number of large-scale pharmaceutical company GH registries...
October 21, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29055142/the-fate-of-the-bone-graft-in-cerebrospinal-fluid-rhinorrhea-endoscopic-repair-for-idiopathic-intracranial-hypertension-a-retrospective-case-series-analysis
#3
A D Workman, R M Carey, A K Parasher, E C Kuan, J Godovchik, J T Glicksman, D W Kennedy, J N Palmer, N D Adappa
INTRODUCTION: Idiopathic intracranial hypertension (IIH) is a common cause of spontaneous cerebrospinal fluid (CSF) leaks necessitating surgical intervention, and grafting of septal, mastoid, or turbinate bone over the defect is increasingly performed to strengthen the repair of the primary defect. However, the postoperative fate of these grafted bone fragments is largely unknown. METHODOLOGY: We performed a retrospective study of patients at the University of Pennsylvania undergoing repair of spontaneous CSF leaks secondary to IIH...
October 21, 2017: Rhinology
https://www.readbyqxmd.com/read/29055132/gram-negative-bacterial-toe-web-infection-a-systematic-review
#4
REVIEW
Till Weidner, Jörg Tittelbach, Tanja Illing, Peter Elsner
Gram-negative bacterial toe web infection (GNBTWI) is a frequent therapeutic challenge in clinical practice with high recurrence rates and frequent need of systemic drugs. The aim of this systematic review was to provide an updated overview and evidence-based data on pathogens, risk-factors and treatment of GNBTWI along with promoting a consistent international terminology. This systematic review is based on a search in PubMed database for English and German articles published between 1980 and 2016. A total of 7 articles were considered appropriate for inclusion in this review regarding to treatment and outcome...
October 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29055052/pregnancy-prior-to-recurrent-pregnancy-loss-more-often-complicated-by-post-term-birth-and-perinatal-death
#5
Marise M Wagner, Jantien Visser, Harjo Verburg, Chantal W P M Hukkelhoven, Jan M M van Lith, Kitty W M Bloemenkamp
INTRODUCTION: The cause of recurrent pregnancy loss remains often unknown. Possibly, pathophysiological pathways are shared with other pregnancy complications. MATERIAL AND METHODS: All women with secondary recurrent pregnancy loss (SRPL) visiting Leiden University Medical Centre (January 2000-2015) were included in this retrospective cohort to assess whether women with SRPL have a more complicated first pregnancy compared to control women. SRPL was defined as ≥ 3 consecutive pregnancy losses before 22 weeks' gestation, with a previous birth...
October 21, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29054962/expanded-alleles-of-the-fmr1-gene-are-related-to-unexplained-recurrent-miscarriages
#6
Xin-Hua Wang, Xiao-Hua Song, Tong Li, Xing-Hua Diao, Qing-Chun Li, Xiang-Hui Zhang, Yan-Lin Wang, Xiao-Hui Deng
Up to 50% of recurrent miscarriage cases in women occur without an underlying etiology. In the current prospective case-control study, we determined the impact of CGG trinucleotide expansions of the FMR1 gene in 49 women with unexplained recurrent miscarriages. Case group consisted of women with 2 or more unexplained consecutive miscarriages. Blood samples were obtained and checked for the presence of expanded alleles of the FMR1 gene using polymerase chain reaction. Patients harboring the expanded allele, with a threshold set to 40 repeats, were further evaluated by sequencing...
October 20, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29054913/treatment-of-recurrent-aneurysms-using-the-woven-endobridge-web-anatomical-and-clinical-results
#7
Matthias Gawlitza, Sebastien Soize, Anne-Christine Januel, Cristian Mihalea, Georgios-Emmanouil Metaxas, Christophe Cognard, Laurent Pierot
BACKGROUND: The safety and efficacy of the Woven EndoBridge (WEB) for the treatment of naïve intracranial aneurysms has been confirmed. PURPOSE: To analyze the safety and efficacy of the WEB in the treatment of recurrent aneurysms. METHODS: Anatomical and clinical results in consecutive patients with a recurrent aneurysm, who were treated using the WEB device in two French neurointerventional centers, were evaluated. RESULTS: Seventeen patients with 17 aneurysms were included...
October 20, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29054896/metastatic-melanoma-of-unknown-primary-in-the-temporalis-muscle
#8
Marco Dalle Carbonare, Mei Xien Goh, Zainab AlshiekhAli, David Howlett
Melanomas are aggressive cancers that present as cutaneous, mucosal and ocular lesions with the ability to metastasise widely. There are, however, occasions where lesions are found in distant sites such as lymph nodes, viscera and subcutaneous tissues without clinically apparent skin involvement. This is known as metastatic melanoma of unknown primary (MUP). Its presentation in skeletal muscle is rare, and the available literature is sparse. This article presents an 85-year-old woman with a MUP presenting in the right temporalis muscle, which was diagnosed with the aid of the ultrasound-guided core biopsy...
October 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054890/natural-killer-t-cell-immunotherapy-in-combination-with-chemotherapy-induced-immunogenic-cell-death-targets-metastatic-breast-cancer
#9
Simon Gebremeskel, Lynnea Lobert, Kaitlyn Tanner, Brynn Walker, Tora Oliphant, Livia E Clarke, Graham Dellaire, Brent Johnston
Natural killer T (NKT) cells are glycolipid-reactive lymphocytes that promote cancer control. In previous studies, NKT-cell activation improved survival and antitumor immunity in a post-surgical mouse model of metastatic breast cancer. Herein, we investigated whether NKT-cell activation could be combined with chemotherapeutic agents to augment therapeutic outcomes. Gemcitabine and cyclophosphamide analogs enhanced the potential immunogenicity of 4T1 mammary carcinoma cells by increasing the expression of antigen-presenting molecules (MHC-I, MHC-II, and CD1d) and promoting exposure or release of immunogenic cell death markers (calreticulin, HMGB1 and ATP)...
October 20, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/29054888/lung-cancer-genetic-predisposition-and-smoking-the-nordic-twin-study-of-cancer
#10
Jacob Hjelmborg, Tellervo Korhonen, Klaus Holst, Axel Skytthe, Eero Pukkala, Julia Kutschke, Jennifer R Harris, Lorelei A Mucci, Kaare Christensen, Kamila Czene, Hans-Olov Adami, Thomas Scheike, Jaakko Kaprio
BACKGROUND: We aimed to disentangle genetic and environmental causes in lung cancer while considering smoking status. METHODS: Four Nordic twin cohorts (43 512 monozygotic (MZ) and 71 895 same sex dizygotic (DZ) twin individuals) had smoking data before cancer diagnosis. We used time-to-event analyses accounting for censoring and competing risk of death to estimate incidence, concordance risk and heritability of liability to develop lung cancer by smoking status...
November 2017: Thorax
https://www.readbyqxmd.com/read/29054864/heterogeneous-patterns-of-genetic-diversity-and-differentiation-in-european-and-siberian-chiffchaff-phylloscopus-collybita-abietinus-p-tristis
#11
Venkat Talla, Faheema Kalsoom, Daria Shipilina, Irina Marova, Niclas Backström
Identification of candidate genes for trait variation in diverging lineages and characterization of mechanistic underpinnings of genome differentiation are key steps towards understanding the processes underlying the formation of new species. Hybrid zones provide a valuable resource for such investigations since they allow for studying how genomes evolve as species exchange genetic material and for associating particular genetic regions with phenotypic traits of interest. Here we use whole-genome resequencing of both allopatric and hybridising populations of the European (Phylloscopus collybita abietinus) and the Siberian chiffchaff (P...
October 20, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29054858/mirna-directed-cancer-therapies-implications-in-melanoma-intervention
#12
Anita Thyagarajan, Ahmed Shaban, Ravi P Sahu
Acquired tumor resistance to cancer therapies pose major challenges in the treatment of cancers including melanoma. Among several signaling pathways or factors that affect neocarcinogenesis, cancer progression and therapies, altered microRNAs (miRNAs) expression has been identified as crucial players in modulating the key pathways governing these events. While studies on miRNA field has grown exponentially in the last decade, much remains to be discovered, particularly with respect to their roles in cancer therapies...
October 20, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29054745/lower-limb-injuries-in-men-s-elite-gaelic-football-a-prospective-investigation-among-division-one-teams-from-2008-to-2015
#13
Mark Roe, John C Murphy, Conor Gissane, Catherine Blake
OBJECTIVES: To prospectively investigate incidence and associated time-loss of lower limb injuries in elite Gaelic football. Additionally, to identify sub-groups of elite players at increased risk of sustaining a lower limb injury. DESIGN: Prospective, epidemiological study. METHODS: Team physiotherapists provided exposure and injury on a weekly basis to the National Gaelic Athletic Association (GAA) Injury Surveillance Database. Injury was defined using a time-loss criterion...
September 6, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29054719/two-cases-of-distal-ulna-giant-cell-tumors-treated-by-extensive-resection-prosthetic-reconstruction-and-stabilization-using-the-brachioradialis-tendon
#14
A Thiounn, E Guerre, C Szymanski, C Maynou, C Fontaine
Aggressive giant cell tumors are rare at the distal ulna. We report the results of two patients who were treated surgically using a distal ulna prosthesis stabilized by ligament reconstruction with the brachioradialis tendon. At the maximum follow-up of 18months, the two patients were satisfied. Joint range of motion and functional scores were improved. X-rays showed no recurrence or subluxation; however gradual impingement of the ulnar notch of radius by the prosthesis was visible. Our technique seems to be a viable alternative when compared with the treatments described in other published case reports...
October 17, 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/29054716/-the-surgery-of-diaphragmatic-hydatidosis-and-their-complications
#15
I Issoufou, H Harmouchi, S Rabiou, L Belliraj, F Z Ammor, A S Diarra, M Lakranbi, R Sani, Y Ouadnouni, M Smahi
Primary or secondary diaphragmatic echinococcosis is rare, accounting for 1% of the thoracic locations. They may be operative discovery or by their complication, hence a variable symptomatology making this localization a particular entity. The thoracic and abdominal CT allows a complete assessment. Surgery remains the only therapeutic approach. In complicated forms an additional surgery is required for complete care. The prognosis is generally good apart from the risk of recurrence. Through a series of 4 operated patients, we focus on the clinical and therapeutic features of this pathology and its complications...
October 17, 2017: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/29054662/assessing-the-ecological-effects-of-water-stress-and-pollution-in-a-temporary-river-implications-for-water-management
#16
Ioannis Karaouzas, Evangelia Smeti, Aikaterini Vourka, Leonidas Vardakas, Aggeliki Mentzafou, Elisabet Tornés, Sergi Sabater, Isabel Muñoz, Nikolaos Th Skoulikidis, Eleni Kalogianni
Temporary rivers are dynamic and complex ecosystems that are widespread in arid and semi-arid regions, such as the Mediterranean. Biotic communities adapted in their intermittent nature could withstand recurrent drought events. However, anthropogenic disturbances in the form of water stress and chemical pollution challenge biota with unpredictable outcomes, especially in view of climate change. In this study we assess the response of the biotic community of a temporary river to environmental stressors, focusing on water stress and pollution...
October 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29054572/chaotic-genetic-algorithm-and-adaboost-ensemble-metamodeling-approach-for-optimum-resource-planning-in-emergency-departments
#17
Milad Yousefi, Moslem Yousefi, Ricardo Poley Martins Ferreira, Joong Hoon Kim, Flavio S Fogliatto
Long length of stay and overcrowding in emergency departments (EDs) are two common problems in the healthcare industry. To decrease the average length of stay (ALOS) and tackle overcrowding, numerous resources, including the number of doctors, nurses and receptionists need to be adjusted, while a number of constraints are to be considered at the same time. In this study, an efficient method based on agent-based simulation, machine learning and the genetic algorithm (GA) is presented to determine optimum resource allocation in emergency departments...
October 17, 2017: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/29054553/long-term-results-of-a-prospective-study-of-anterior-decompression-with-fusion-and-posterior-decompression-with-laminoplasty-for-treatment-of-cervical-spondylotic-myelopathy
#18
Takashi Hirai, Toshitaka Yoshii, Kenichiro Sakai, Hiroyuki Inose, Tsuyoshi Yamada, Tsuyoshi Kato, Shigenori Kawabata, Yoshiyasu Arai, Kenichi Shinomiya, Atsushi Okawa
BACKGROUND: There have been no prospective studies comparing anterior surgery and posterior method in terms of long-term outcomes. The purposes of this study is to clarify whether there is any difference in long-term clinical and radiologic outcomes of anterior decompression with fusion (ADF) and laminoplasty (LAMP) for the treatment of cervical spondylotic myelopathy (CSM). METHODS: Ninety-five patients were prospectively treated with ADF or LAMP for CSM in our hospital from 1996 through 2003...
October 17, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29054544/-abnormalities-of-dna-repair-and-gynecological-cancers
#19
REVIEW
Aurélie Auguste, Alexandra Leary
The demonstration of frequent defects in the DNA damage response in high grade ovarian cancer has paved the way for a new therapeutic approach aimed at exploiting this unique vulnerability. The efficacy of poly (ADP) ribose polymerase inhibitors (PARPi) in patients with homologous recombination (HR) DNA repair deficient ovarian cancer (OC) resulting from a BRCA1/2 mutation has provided the proof of concept for synthetic lethality. Thus, olaparib is now approved by the EMA as maintenance therapy after response to a platinum regimen for patients with recurrent, platinum-sensitive, high-grade serous, BRCA1/2-mutated ovarian cancer...
October 17, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/29054532/a-randomized-clinical-trial-indicates-that-levamisole-increases-the-time-to-relapse-in-children-with-steroid-sensitive-idiopathic-nephrotic-syndrome
#20
Mariken P Gruppen, Antonia H Bouts, Marijke C Jansen-van der Weide, Maruschka P Merkus, Aleksandra Zurowska, Michal Maternik, Laura Massella, Francesco Emma, Patrick Niaudet, Elisabeth A M Cornelissen, Thierry Schurmans, Ann Raes, Johan van de Walle, Mieke van Dyck, Ashima Gulati, Arvind Bagga, Jean-Claude Davin
Levamisole has been considered the least toxic and least expensive steroid-sparing drug for preventing relapses of steroid-sensitive idiopathic nephrotic syndrome (SSINS). However, evidence for this is limited as previous randomized clinical trials were found to have methodological limitations. Therefore, we conducted an international multicenter, placebo-controlled, double-blind, randomized clinical trial to reassess its usefulness in prevention of relapses in children with SSINS. The efficacy and safety of one year of levamisole treatment in children with SSINS and frequent relapses were evaluated...
October 17, 2017: Kidney International
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