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https://www.readbyqxmd.com/read/29677641/a-randomised-controlled-trial-of-1-year-adjuvant-chemotherapy-with-oral-tegafur-uracil-versus-surgery-alone-in-stage-ii-colon-cancer-sacura-trial
#1
Chu Matsuda, Megumi Ishiguro, Satoshi Teramukai, Yoshiki Kajiwara, Shoichi Fujii, Yusuke Kinugasa, Yoshihiko Nakamoto, Masanori Kotake, Yoshiyuki Sakamoto, Kiyotaka Kurachi, Atsuyuki Maeda, Koji Komori, Naohiro Tomita, Yasuhiro Shimada, Keiichi Takahashi, Kenjiro Kotake, Masahiko Watanabe, Hidetaka Mochizuki, Yoko Nakagawa, Kenichi Sugihara
BACKGROUND: Efficacy of adjuvant chemotherapy in patients with stage II colon cancer is still controversial. The SACURA trial is a randomised-controlled study evaluating the superiority of 1-year adjuvant treatment with oral tegafur-uracil (UFT) to surgery alone for stage II colon cancer. METHODS: Patients were randomly assigned to the surgery-alone group or UFT group (UFT at 500-600 mg/day for 5 days, followed by 2-day rest, for 1 year). The primary end-point was disease-free survival (DFS)...
April 17, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29677250/review-in-cryptogenic-stroke-with-pfo-adding-pfo-closure-to-medical-therapy-reduces-recurrence
#2
Nabeel M Syed, Wieslaw Oczkowski
No abstract text is available yet for this article.
April 17, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29677180/do-inhaled-corticosteroids-have-a-role-for-bronchiolitis
#3
Gonzalo Alarcón-Andrade, Lorena Cifuentes
INTRODUCTION: Bronchiolitis consists of an acute small airways inflammation secondary to a viral infection and is a frequent pathology among children under 2 years. The use of inhaled corticosteroids during bronchiolitis has been proposed to reduce recurrent wheeze or asthma, however there is controversy about it. METHODS: To answer this question we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others...
April 17, 2018: Medwave
https://www.readbyqxmd.com/read/29676944/integration-of-clinical-variables-for-the-prediction-of-late-distant-recurrence-in-patients-with-estrogen-receptor-positive-breast-cancer-treated-with-5-years-of-endocrine-therapy-cts5
#4
Mitch Dowsett, Ivana Sestak, Meredith M Regan, Andrew Dodson, Giuseppe Viale, Beat Thürlimann, Marco Colleoni, Jack Cuzick
Purpose Estimating risk of late distant recurrence (DR) is an important goal for managing women with hormone receptor-positive breast cancer after 5 years of endocrine treatment without recurrence. We developed and validated a simple clinicopathologic tool (Clinical Treatment Score post-5 years [CTS5]) to estimate residual risk of DR after 5 years of endocrine treatment. Patients and Methods The ATAC (Arimidex, Tamoxifen, Alone or in Combination) data set (N = 4,735) was used to create a prognostic score for post-5-year risk of DR...
April 20, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29676717/-supervising-quality-of-care-through-the-patients-eyes-a-different-approach-to-inspection-is-required
#5
R J R Bouwmans, P B M Robben, R D Friele
The Netherlands Health and Youth Care Inspectorate (IGJ) wants to take the patient's perspective into account more often in its supervision of quality of care. The inspectorate already has some insight into this perspective via patients' reports; patients report complaints with the aim of preventing recurrence of the problem. However, the inspectorate does not further investigate the vast majority of these complaints and, furthermore, complaints with a clinical aspect are investigated far more often than organisational or communicational problems...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29676711/-intraoperative-neuromonitoring-in-endocrine-surgery-when-is-it-appropriate
#6
A F Engelsman, E J M Nieveen van Dijkum
The use of intraoperative neuromonitoring (IONM) in thyroid surgery has steadily increased in recent years. This technique helps to identify different nerves in and around the operation site, such as the recurrent laryngeal nerve (RLN) and the external branch of the superior laryngeal nerve. Particularly in patients who undergo a second operation or a complex procedure for malignancy, the technique's value has been demonstrated. However, in non-complex thyroid operations the risk of vocal cord paresis due to iatrogenic injury of the RLN is 0...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29676696/tentorial-sling-for-microvascular-decompression-in-patients-with-trigeminal-neuralgia-a-description-of-operative-technique-and-clinical-outcomes
#7
Jeffrey A Steinberg, Jayson Sack, Bayard Wilson, David Weingarten, Bob Carter, Alexander Khalessi, Sharona Ben-Haim, John Alksne
OBJECTIVE Trigeminal neuralgia is a debilitating pain disorder most often caused by arterial compression of the trigeminal nerve, although there are other etiologies. Microvascular decompression (MVD) remains the most definitive treatment for this disorder, with cure rates reported between 60% and 80%. Traditional MVD techniques involve a retrosigmoid craniotomy with placement of an inert foreign material, such as Teflon, between the nerve and compressive vessel. Recurrence of trigeminal neuralgia after MVD has been associated with vessel migration, adhesion formation, and arterial pulsation against the Teflon abutting the nerve...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29676694/keyhole-strategy-aiming-at-minimizing-hospital-stay-for-surgical-clipping-of-unruptured-middle-cerebral-artery-aneurysms
#8
Kentaro Mori, Kojiro Wada, Naoki Otani, Arata Tomiyama, Terushige Toyooka, Satoru Takeuchi, Takuji Yamamoto, Yasuaki Nakao, Hajime Arai
OBJECTIVE Aneurysms of the middle cerebral artery (MCA) are still most often treated by clipping through standard craniotomy, but a longer hospital stay is one of the main drawbacks of this treatment. The authors developed a pterional keyhole clipping strategy for unruptured MCA aneurysms with the intention of minimizing hospital stay. In this paper, they report on their experience with this approach and analyze the long-term neurological and radiological outcomes. METHODS A total of 160 relatively small unruptured MCA aneurysms (mean 6...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29676690/does-size-matter-investigating-the-optimal-planning-target-volume-margin-for-postoperative-stereotactic-radiosurgery-to-resected-brain-metastases
#9
Jaymin Jhaveri, Mudit Chowdhary, Xinyan Zhang, Robert H Press, Jeffrey M Switchenko, Matthew J Ferris, Tiffany M Morgan, Justin Roper, Anees Dhabaan, Eric Elder, Bree R Eaton, Jeffrey J Olson, Walter J Curran, Hui-Kuo G Shu, Ian R Crocker, Kirtesh R Patel
OBJECTIVE The optimal margin size in postoperative stereotactic radiosurgery (SRS) for brain metastases is unknown. Herein, the authors investigated the effect of SRS planning target volume (PTV) margin on local recurrence and symptomatic radiation necrosis postoperatively. METHODS Records of patients who received postoperative LINAC-based SRS for brain metastases between 2006 and 2016 were reviewed and stratified based on PTV margin size (1.0 or > 1.0 mm). Patients were treated using frameless and framed SRS techniques, and both single-fraction and hypofractionated dosing were used based on lesion size...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29676670/timing-severity-of-deficits-and-clinical-improvement-after-surgery-for-spinal-dural-arteriovenous-fistulas
#10
Michael M Safaee, Aaron J Clark, Jan-Karl Burkhardt, Ethan A Winkler, Michael T Lawton
OBJECTIVE Spinal dural arteriovenous fistulas (dAVFs) are rare vascular abnormalities caused by arteriovenous shunting. They often form at the dural root sleeve between a radicular feeding artery and draining medullary vein causing venous congestion and edema, decreased perfusion, and ischemia of the spinal cord. Treatment consists of either surgical ligation of the draining vein or selective embolization via an endovascular approach. There is a paucity of data on which modality provides more durable and effective outcomes...
April 20, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29676378/extranodal-histiocytic-sarcoma-in-a-child-with-acute-lymphoblastic-leukemia-cytomorphological-features-of-a-rare-entity-with-brief-review-of-literature
#11
Krushna Chandra Pani, Mahima Yadav, Shaleen Kumar, Vinita Agrawal
Histiocytic sarcoma (HS) is a rare malignant neoplasm showing morphologic and immunophenotypic evidence of histiocytic differentiation. We describe a rare case of synchronous HS in a patient of B-cell acute lymphoblastic leukemia (ALL). A 16-year-old boy diagnosed as ALL also presented with a swelling over the right Achilles tendon. The cytological features of the swelling suggested a histiocytic lesion. Histological and immunohistochemical examination clinched the diagnosis of HS. The available 5-year follow-up showed no recurrence...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29676375/bone-marrow-oxalosis-an-unusual-cause-of-cytopenia-in-end-stage-renal-disease-report-of-two-cases
#12
Seema Sharma, Ram Nawal Rao, Krushna Chandra Pani, Paramita Paul
Systemic oxalosis can be either primary or secondary hyperoxaluria. Oxalosis is a phenomenon in which calcium oxalate crystals deposit in various visceral organs leading to bone marrow (BM) failure and recurrent renal stones. We describe two rare cases of BM oxalosis. Hyperoxaluria is strongly associated with nephrolithiasis and nephrocalcinosis. Both the patients presented with recurrent renal stones and a variable degree of BM failure. BM oxalosis should be considered as a possible diagnosis in patients in recurrent nephrolithiasis and cytopenia...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29676366/pindborg-tumor-pathology-with-special-stains
#13
Swati Shrikant Gotmare, Treville Pereira, Subraj Shetty, Kashmira S Kesarkar
Odontogenic tumors constitute a wide spectrum of lesions ranging from malignant and benign neoplasms to dental hamartomas, all derived from the epithelial and ectomesenchymal remnants of the tooth forming apparatus. Calcifying epithelial odontogenic tumor (CEOT) is an uncommon, benign epithelial odontogenic tumor first described by Pindborg in 1956. It is a universally accepted eponym for this neoplasm. Pindborg tumor or CEOT is a locally aggressive neoplasm that accounts for 1% of the total odontogenic tumors, with recurrence in 14% of cases...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29676355/the-determination-of-stage-in-nonmuscle-urothelial-carcinoma-staining-pattern-of-caspase-8
#14
Nilay Şen Türk, Saadettin Eskiçorapçi, Zafer Aybek, Levent Tuncay
Context: Urothelial carcinoma (UC) is one of the most frequent epithelial tumors worldwide. Aims: We aimed to investigate the protein expressions of caspase-8, p53, murine double minute 2 (mdm2), and p14ARF in nonmuscle UCs and to correlate the findings with clinicopathological characteristics. Settings and Design: A total of 50 patients who had pTa and pT1 tumors were analyzed. Subjects and Methods: The protein expressions of caspase-8, p53, mdm2, and p14ARF were analyzed by immunohistochemistry...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29676340/progesterone-receptor-expression-and-ki-67-labelling-index-of-meningiomas-in-the-lagos-university-teaching-hospital
#15
Nzechukwu Zimudo Ikeri, Charles Chidozie Anunobi, Olufemi B Bankole
Background: Meningioma in Nigeria has been poorly studied. Its location within the intracranial cavity is associated with significant morbidity and mortality. Even when completely excised, it has a tendency to recur and this is associated with repeat operations and shortened survival. The World Health Organization (WHO) grade, progesterone receptor (PR) expression and Ki-67 index are predictive for recurrence and are, therefore, useful for individualised management. The aim of this study was therefore to determine the PR expression and Ki-67 index of meningiomas received in our institution...
January 2018: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29676336/erratum-isolated-neurofibroma-of-the-eyelid-mimicking-recurrent-chalazion
#16
(no author information available yet)
[This corrects the article DOI: 10.4103/ijo.IJO_852_17].
May 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29676331/cervicofacial-emphysema-following-unilateral-external-dacryocystorhinostomies-a-case-report
#17
Ziya Akingol, Safak Karslioglu, Didem Serin
Cervicofacial emphysema (CFE), mostly seen after trauma or dental procedures, is an unexpected, extremely rare condition after uncomplicated dacryocystorhinostomy (DCR). It may be misdiagnosed as angioedema or necrotizing fasciitis. In this article, we present the case of a 40-year-old female with CFE twice after uncomplicated unilateral DCR for left and right sides on different operative days. CFE was confirmed by computed tomography, demonstrating extensive air within subcutaneous tissues of the face, neck, and orbital cavity...
May 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29676328/papilledema-revisiting-after-sinus-angioplasty-of-chronic-cerebral-venous-sinus-thrombosis
#18
Vaibhav Kumar Jain, Vivek Singh, Vikas Kannaujia, Priyadarshini Mishra, Rajendra Vishnu Phadke, Kumudini Sharma
This case series aimed to review the significance of revisiting papilledema after successful cerebral venous sinus thrombosis (CVST) management with sinus angioplasty. Four patients presented with blurring and transient obscuration of vision with papilledema, headache, tinnitus, and vomiting. On magnetic resonance venography and digital subtraction angiography, chronic transverse sinus thrombosis was diagnosed for which patients underwent endovascular intervention (stenting). After the resolution of CVST, patients developed the recurrence of symptoms which on digital subtraction angiography revealed dural arteriovenous malformation (DAVM)...
May 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29676325/recurrent-vitreous-hemorrhage-secondary-to-retinal-vessel-avulsion
#19
Deivy Cruzado-Sanchez, Sergio Mucching-Toscano, Walter A Tellez, Silvio Lujan, Hugo Luglio-Valdivieso
Spontaneous vitreous hemorrhage is a rare entity, present in 7 out of 100,000 inhabitants. It is associated with different pathologies; however, it is rarely reported to be caused by retinal vessel avulsion syndrome. In the present manuscript, we report a case of avulsion of retinal vessels associated with recurrent vitreous hemorrhage managed, at first, by photocoagulation, but due to the several recurrence of bleeding, the patient went into surgical management.
May 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29676322/corneal-fibroma-an-uncommon-stromal-tumor
#20
Akshay Gopinathan Nair, Hemal Kenia, Indumati Gopinathan, Siddharth V Mehta, Vinod C Mehta
A 56-year-old male patient presented with a slow-growing, elevated, smooth, white corneal mass. The mass was excised by performing an alcohol-assisted keratoepitheliectomy and sent for histopathological examination. Subepithelially, closely packed spindle cells in "feather-stitched" or storiform pattern were seen. Immunohistochemically, the cells stained negatively for CD-34 and S-100 and focal positivity was seen for vimentin. Based on the morphology and immunochemical staining, a diagnosis of corneal fibroma was made...
May 2018: Indian Journal of Ophthalmology
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