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https://www.readbyqxmd.com/read/29452444/risk-of-venous-thrombosis-in-antithrombin-deficiency-a-systematic-review-and-bayesian-meta-analysis
#1
F Nanne Croles, Jaime Borjas-Howard, Kazem Nasserinejad, Frank W G Leebeek, Karina Meijer
Antithrombin deficiency is a strong risk factor for venous thromboembolism (VTE), but the absolute risk of the first and recurrent VTE is unclear. The objective of this paper is to establish the absolute risks of the first and recurrent VTE and mortality in individuals with antithrombin deficiency. The databases Embase, Medline Ovid, Web of Science, the Cochrane Library, and Google Scholar were systematically searched for case-control and cohort studies. Bayesian random-effects meta-analysis was used to calculate odds ratios (ORs), absolute risks, and probabilities of ORs being above thresholds...
February 16, 2018: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/29452422/asynchronous-and-pathological-windows-of-implantation-two-causes-of-recurrent-implantation-failure
#2
P Sebastian-Leon, N Garrido, J Remohí, A Pellicer, P Diaz-Gimeno
STUDY QUESTION: Is endometrial recurrent implantation failure (RIF) only a matter of an asynchronous (displaced) window of implantation (WOI), or could it also be a pathological (disrupted) WOI? SUMMARY ANSWER: Our predictive results demonstrate that both displaced and disrupted WOIs exist and can present independently or together in the same RIF patient. WHAT IS KNOWN ALREADY: Since 2002, many gene expression signatures associated with endometrial receptivity and RIF have been described...
February 14, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29452419/temozolomide-associated-hypermutation-in-gliomas
#3
Serah Choi, Yao Yu, Matthew R Grimmer, Michael Wahl, Susan M Chang, Joseph F Costello
Low-grade gliomas cause considerable morbidity and most will recur after initial therapy. At recurrence, low-grade gliomas can undergo transformation to high-grade gliomas (grade III or grade IV), which are associated with worse prognosis. Temozolomide (TMZ) provides survival benefit in patients with glioblastomas (GBMs) but its value in patients with low-grade gliomas is less clear. A subset of TMZ-treated, IDH-mutant, low-grade astrocytomas recur as more malignant tumors with thousands of de novo, coding mutations bearing a signature of TMZ-induced hypermutation...
February 14, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29452402/mitotane-monotherapy-in-patients-with-advanced-adrenocortical-carcinoma
#4
Felix Megerle, Wiebke Herrmann, Wiebke Schloetelburg, Cristina L Ronchi, Alina Pulzer, Marcus Quinkler, Felix Beuschlein, Stefanie Hahner, Matthias Kroiss, Martin Fassnacht
Context: While mitotane is the only approved drug for the treatment of adrenocortical carcinoma (ACC), data on monotherapy in advanced disease is still scarce. Objective: To assess the efficacy of mitotane in advanced ACC in a contemporary setting and to identify predictive factors. Design/Setting: Multicenter cohort study of three German referral centers. Patients: 127 patients with advanced ACC treated with mitotane monotherapy...
February 14, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29452326/awake-microvascular-decompression-for-trigeminal-neuralgia-concept-and-initial-results
#5
Saleem I Abdulrauf, Jorge F Urquiaga, Ritesh Patel, J Andrew Albers, Varun B Sampat, Meghan Baumer, Eric Marvin, Matthew Pierson, Raquel Kragel, Jodi Walsh
OBJECTIVE: The option of performing MVD under awake anesthesia protocol ("awake" MVD) was examined in this initial series to assess whether intraoperative pain evaluation can identify and mitigate insufficient decompression of the trigeminal nerve, improving surgical outcomes. Additionally, "awake" MVD could expand procedure indications for those with comorbidities that would prohibit general endotracheal anesthesia (GEA). METHODS: An IRB-approved prospective study of 10 consecutive adults who underwent MVD for TN was conducted...
February 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29452300/therapeutic-strategy-for-rheumatoid-arthritis-patients-who-have-achieved-remission
#6
Bruno Fautrel
Once remission or low disease activity (LDA) is attained in established rheumatoid arthritis (RA) patients, attempting disease-modifying anti-rheumatic drug (DMARD) tapering appears to be a viable option to avoid patient overtreatment. Potential benefits include reduction in the treatment burden and the risk of adverse events, although the latter has not been demonstrated convincingly.The feasibility of DMARD discontinuation has been tested in numerous studies or trials. All have revealed a high risk of relapse, ranging from 56% to 87% at one year...
February 13, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29452247/persistent-candidemia-despite-appropriate-fungal-therapy-first-case-of-candida-auris-from-the-united-arab-emirates
#7
Adnan Alatoom, Mohammad Sartawi, Karen Lawlor, Laila AbdelWareth, Jens Thomsen, Ahmad Nusair, Imran Mirza
In this case, we report an elderly patient with multiple chronic conditions and prolonged intensive care units (ICU) stay who had recurrent Candida auris (C. auris) in blood despite antifungal therapy. C. auris was misidentified using conventional automated identification system as Candida haemulonii resulting in delayed diagnosis. The isolate showed increasing minimum inhibitory concentrations (MICs) to different antifungal drugs and persisted in the patient's blood before the patient deceased. This is the first case of C...
February 13, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29452228/a-bach2-gene-variant-is-associated-with-postoperative-recurrence-of-crohn-s-disease
#8
Michael R Laffin, Richard N Fedorak, Eytan Wine, Bryan Dicken, Karen L Madsen
BACKGROUND: Crohn's disease often requires intestinal resection, which is not considered curative. Repeat surgical intervention is necessary in over half of the patients following their initial operation. Although many genetic loci are implicated in Crohn's disease, few have been associated with post-resection recurrence. STUDY DESIGN: A cohort of Crohn's disease subjects who underwent intestinal resection was analyzed to determine genetic and clinical factors associated with post-resection recurrence...
February 13, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29452208/outcome-of-abo-incompatible-adult-living-donor-liver-transplantation-for-patients-with-hepatocellular-carcinoma
#9
Young-In Yoon, Gi-Won Song, Sung-Gyu Lee, Shin Hwang, Ki-Hun Kim, Seok-Hwan Kim, Woo-Hyoung Kang, Hwui-Dong Cho, Eun-Kyoung Jwa, Jae-Hyun Kwon, Eun-Young Tak, Varvara A Kirchner
BACKGROUND & AIMS: Living-donor liver transplantation (LDLT) can simultaneously cure hepatocellular carcinoma (HCC) and underlying liver cirrhosis, improving long-term results in patients with HCC. ABO-incompatible LDLT could expand the living-donor pool, reduce waiting times for deceased-donor liver transplantation, and improve long-term survival for some patients with HCC. METHODS: We retrospectively reviewed the medical records of patients undergoing LDLT for HCC from November 2008 to December 2015 at a single institution in Korea...
February 13, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29452116/bioprosthetic-versus-mechanical-valve-replacement-for-endocarditis-focus-on-recurrence-rates-commentary
#10
Thoralf M Sundt
No abstract text is available yet for this article.
February 13, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29452115/bioprosthetic-versus-mechanical-valve-replacement-for-infective-endocarditis-focus-on-recurrence-rates
#11
Nana Toyoda, Shinobu Itagaki, Henry Tannous, Natalia N Egorova, Joanna Chikwe
BACKGROUND: Consensus guidelines for prosthesis selection in infective endocarditis recommend bioprosthetic or mechanical valve replacement based on life expectancy and comorbidity. However, contemporary outcome data are limited to institution series. METHODS: The outcomes of 3,447 patients identified from mandatory discharge databases in California and New York states who had either primary isolated mitral (n=1603) or aortic (n=1,844) valve replacement for active endocarditis between 1998 and 2010, were compared according to whether they received bioprosthetic (n=1,673, 48...
February 13, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29452099/a-systematic-review-and-meta-analysis-comparing-pigtail-catheter-and-chest-tube-as-the-initial-treatment-for-pneumothorax
#12
Su-Huan Chang, Yi-No Kang, Hsin-Yi Chiu, Yu-Han Chiu
BACKGROUND: The optimal initial treatment approach for pneumothorax remains controversial. This systemic review and meta-analysis investigated the effectiveness of small-bore pigtail catheter (PC) drainage in comparison with that of large-bore chest tube (LBCT) drainage as the initial treatment approach for all subtypes of pneumothorax. METHODS: We systematically searched PubMed and Embase for observational studies and randomized controlled trials published up to October 9, 2017, that compared PC and LBCT as the initial treatment for pneumothorax...
February 13, 2018: Chest
https://www.readbyqxmd.com/read/29451964/a-long-term-comparative-prospective-study-between-reinnervation-and-injection-laryngoplasty
#13
SeungWon Lee, KiNam Park
OBJECTIVES: This study compared and assessed long-term voice outcomes when thyroidectomy-related unilateral vocal fold paralysis (VFP) was managed using injection laryngoplasty (IL) and recurrent laryngeal nerve reinnervation (RLNR). STUDY DESIGN: Prospective clinical study. METHODS: A prospective clinical trial was performed from March 2005 to January 2016 at Soonchunhyang University Bucheon Hospital (Bucheon, South Korea). Nineteen patients who underwent ansa cervicalis to RLNR or direct reinnervation, and 43 patients who underwent IL to treat thyroidectomy-related unilateral VFP, were enrolled...
February 16, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29451912/expression-of-cell-cycle-regulators-and-frequency-of-tp53-mutations-in-high-risk-gastrointestinal-stromal-tumors-prior-to-adjuvant-imatinib-treatment
#14
Michaela Angelika Ihle, Sebastian Huss, Wiebke Jeske, Wolfgang Hartmann, Sabine Merkelbach-Bruse, Hans-Ulrich Schildhaus, Reinhard Büttner, Harri Sihto, Kirsten Sundby Hall, Mikael Eriksson, Peter Reichardt, Heikki Joensuu, Eva Wardelmann
Despite of multitude investigations no reliable prognostic immunohistochemical biomarkers in GIST have been established so far with added value to predict the recurrence risk of high risk GIST besides mitotic count, primary location and size. In this study, we analyzed the prognostic relevance of eight cell cycle and apoptosis modulators and of TP53 mutations for prognosis in GIST with high risk of recurrence prior to adjuvant treatment with imatinib. In total, 400 patients with high risk for GIST recurrence were randomly assigned for adjuvant imatinib either for one or for three years following laparotomy...
2018: PloS One
https://www.readbyqxmd.com/read/29451891/association-of-an-intact-e2-gene-with-higher-hpv-viral-load-higher-viral-oncogene-expression-and-improved-clinical-outcome-in-hpv16-positive-head-and-neck-squamous-cell-carcinoma
#15
Nicole V Anayannis, Nicolas F Schlecht, Miriam Ben-Dayan, Richard V Smith, Thomas J Belbin, Thomas J Ow, Duk M Blakaj, Robert D Burk, Sarah M Leonard, Ciaran B Woodman, Joanna L Parish, Michael B Prystowsky
To assess the relationship of E2 gene disruption with viral gene expression and clinical outcome in human papillomavirus (HPV) positive head and neck squamous cell carcinoma, we evaluated 31 oropharyngeal and 17 non-oropharyngeal HPV16 positive carcinomas using two PCR-based methods to test for disruption of E2, followed by Sanger sequencing. Expression of HPV16 E6, E7 and E2 transcripts, along with cellular ARF and INK4A, were also assessed by RT-qPCR. Associations between E2 disruption, E2/E6/E7 expression, and clinical outcome were evaluated by Kaplan-Meier analysis for loco-regional recurrence and disease-specific survival...
2018: PloS One
https://www.readbyqxmd.com/read/29451522/-management-of-benign-esophageal-strictures-a-literature-review
#16
Leonardo Frazzoni, Marina La Marca, Amedeo Montale, Lorenzo Fuccio
The management of benign esophageal strictures is challenging. The first strategy includes endoscopic dilation using bougies or balloons. Although the immediate success rate of these is up to 90%, about 30-40% of patients experience recurrent dysphagia within the first year of follow-up. The management of refractory stenosis involves repeated sessions of endoscopic dilation. In order to obtain long-lasting functional results, alternative treatments have been developed, such as the use of self-expanding stents, particularly indicated in subgroups of patients with post-surgical stenosis or post-radiation therapy...
January 2018: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29451422/intraperitoneal-onlay-mesh-technique-for-spigelian-hernia-in-an-outpatient-and-short-stay-surgery-unit-whats-new-in-intraperitoneal-meshes
#17
María Carmen Fernández-Moreno, Elena Martí-Cuñat, Guillermo Pou, Joaquín Ortega
BACKGROUND: Spigelian hernia (SH) is a rare entity, but its surgical treatment is essential because of its high complication risk. Laparoscopic approaches have become the option in elective surgery because it has less morbidity and requires a shorter stay. Several laparoscopic techniques have been employed, but there is no gold standard technique for this kind of hernia. We report, in this study, our experience with intraperitoneal onlay mesh (IPOM) repair. MATERIALS AND METHODS: Fifteen patients underwent elective surgery for SH between 2008 and 2015 in a Short-Stay Surgical Unit...
February 16, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29451360/defining-optimal-surgical-treatment-for-recurrent-hepatocellular-carcinoma-a-propensity-score-matched-analysis
#18
Ka Wing Ma, Kenneth S H Chok, Brian Wong Hoi She, Albert Chi Yan Chan, Tan To Cheung, Jeff Wing Chiu Dai, James Yan Yue Fung, Chung Mau Lo
No abstract text is available yet for this article.
February 16, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29451304/distinct-methylation-profile-of-mucinous-ovarian-carcinoma-reveals-susceptibility-to-proteasome-inhibitors
#19
Phui-Ly Liew, Rui-Lan Huang, Yu-Chun Weng, Chia-Lang Fang, Tim Hui-Ming Huang, Hung-Cheng Lai
Mucinous type of epithelial ovarian cancer (MuOC) is a unique subtype with a poor survival outcome in recurrent and advanced stages. The role of type-specific epigenomics and its clinical significance remain uncertain. We analyzed the methylomic profiles of six benign mucinous adenomas, 24 MuOCs, 103 serous type of epithelial ovarian cancers (SeOCs), and 337 nonepithelial ovarian cancers. MuOC and SeOC exhibited distinct DNA methylation profiles comprising 101 genes, 81 of which exhibited low methylation in MuOC and were associated with the response to glucocorticoid, ATP hydrolysis-coupled proton transport, proteolysis involved in the cellular protein catabolic process, and ion transmembrane transport...
February 16, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29451197/erratum-extranodal-natural-killer-t-cell-lymphoma-nasal-type-presenting-as-recurrent-facial-cellulitis
#20
(no author information available yet)
[This corrects the article DOI: 10.4103/ijdvl.IJDVL_687_16.].
2018: Indian Journal of Dermatology, Venereology and Leprology
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