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https://www.readbyqxmd.com/read/29908524/neoadjuvant-radiotherapy-changing-the-treatment-sequence-to-allow-immediate-free-autologous-breast-reconstruction
#1
Kimberley Hughes, Derek Neoh
BACKGROUND:  Locally advanced breast cancer (LABC) is traditionally treated with a multimodal approach of chemotherapy, surgery, and postmastectomy radiotherapy (PMRT). The advantages of immediate breast reconstruction (IBR) are well described and include improved aesthetic outcomes, fewer surgical procedures, shorter treatment period, and a higher quality of life. However, this sequence makes immediate free autologous reconstruction more challenging as PMRT can have deleterious and unpredictable effects on the flap...
June 16, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29908480/maintenance-treatment-of-recurrent-ovarian-cancer-is-it-ready-for-prime-time
#2
REVIEW
Paul DiSilvestro, Angeles Alvarez Secord
Approximately 1% of women in the United States will be diagnosed with epithelial ovarian cancer (EOC) during their lifetime. It is most likely to present at a more advanced stage, requiring aggressive therapeutic measures, and most women will succumb to this illness. Due to advancements in therapy, the oncology community has begun to shift its focus to molecular targeted agents, alternative dosing schedules, and maintenance therapy. Women who achieve a response to initial adjuvant chemotherapy may be candidates for maintenance therapy, with the goal of inducing a lasting remission or prolonging the disease-free interval before recurrence...
June 5, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29908420/ticagrelor-versus-clopidogrel-after-fibrinolytic-therapy-in-patients-with-st-elevation-myocardial-infarction-rationale-and-design-of-the-ticagrelor-in-patients-with-st-elevation-myocardial-infarction-treated-with-thrombolysis-treat-trial
#3
Otavio Berwanger, Jose C Nicolau, Antonio C Carvalho, Lixin Jiang, Shaun Goodman, Stephen J Nicholls, Alexander Parkhomenko, Oleg Averkov, Carlos Tajer, Germán Malaga, Jose F Kerr Saraiva, Francisco Fonseca, Helio P Guimaraes, Pedro G M de Barros E Silva, Lucas P Damiani, Denise M Paisani, Camila M R Lasagno, Carolina T Candido, Nanci Valeis, Diogo D F Moia, Leopoldo S Piegas, Christopher B Granger, Harvey White, Renato D Lopes
BACKGROUND: The safety and efficacy of ticagrelor in patients with ST-elevation myocardial infarction (STEMI) treated with fibrinolytic therapy remain uncertain. OBJECTIVES: The primary objective of the TicagRElor in pAtients with ST elevation myocardial infarction treated with Thrombolysis (TREAT) trial is to evaluate the short-term safety of ticagrelor when compared with clopidogrel in STEMI patients treated with fibrinolytic therapy. Key secondary objectives are to assess the safety and efficacy of ticagrelor compared with clopidogrel at 12-months...
March 3, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29908389/development-and-validation-of-a-clinical-prediction-tool-to-estimate-the-individual-risk-of-depressive-relapse-or-recurrence-in-individuals-with-recurrent-depression
#4
Nicola S Klein, Gea A Holtman, Claudi L H Bockting, Martijn W Heymans, Huibert Burger
OBJECTIVES: Many studies examined predictors of depressive relapse/recurrence but no simple tool based on well-established risk factors is available that estimates the risk within an individual. We developed and validated such a prediction tool in remitted recurrently depressed individuals. METHODS: The tool was developed using data (n = 235) from a pragmatic randomised controlled trial in remitted recurrently depressed participants and externally validated using data (n = 209) from a similar randomised controlled trial of remitted recurrently depressed participants using maintenance antidepressants...
June 8, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29908377/a-perinatal-approach-to-genetic-disorders-in-irish-travellers-a-review
#5
REVIEW
Fionnuala Mone, Fionnuala M McAuliffe, Sally Ann Lynch
Irish Travellers are an endogamous nomadic ethnic minority population mostly resident on the island of Ireland with smaller populations living in Europe & USA. As they practice consanguinity, rare and ultra-rare autosomal recessive conditions are observed which are infrequently seen in the general population. Awareness of the rare genetic disorders within an antenatal setting that recur within this population should facilitate quicker cost-effective diagnosis. These include disorders leading to recurrent miscarriage and multiple congenital anomalies...
June 9, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29908352/man1b-cdg-novel-variants-with-a-distinct-phenotype-and-review-of-literature
#6
Meena Balasubramanian, Diana S Johnson
BACKGROUND: Congenital disorders of glycosylation (CDG) are a group of rare metabolic diseases due to impaired lipid and protein glycosylation. It comprises a characteristic high frequency of intellectual disability (ID) and a wide range of clinical phenotypes. OBJECTIVE: (s): To identify the underlying diagnosis in two families each with two siblings with variable level of ID through trio whole exome sequencing. METHODS: Both the families were recruited to the Deciphering Developmental Disorders (DDD) study to identify the aetiology for their ID...
June 13, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29908339/radical-hysterectomy-efficacy-and-safety-in-the-dawn-of-minimally-invasive-techniques
#7
Antonio Gil-Moreno, Melchor Carbonell-Socias, Sabina Salicrú, Cristina Centeno-Mediavilla, Silvia Franco-Camps, Eva Colas, Ana Oaknin, Assumpció Pérez-Benavente, Berta Díaz-Feijoo
STUDY OBJECTIVE: To analyze the effect that the introduction of minimally invasive procedures has had on surgical and oncological outcomes when compared with conventional open radical hysterectomy (ORH) in a national reference cancer after 17 years of experience in radical hysterectomy (RH). DESIGN: A prospective controlled study (Canadian Task Force II-2) SETTING: A university teaching hospital PATIENTS: All patients that underwent RH as primary treatment for cervical cancer in our institution between May 1999 and June 2016, with a total of 188 patients...
June 13, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29908338/surgical-and-oncologic-outcomes-of-radical-abdominal-trachelectomy-versus-hysterectomy-for-stage-ia2-ib1-cervical-cancer
#8
Jing Guo, Ying Zhang, Xiaofei Chen, Lin Sun, Kai Chen, Xiugui Sheng
STUDY OBJECTIVE: To compare the surgical and oncologic outcomes between radical abdominal trachelectomy and radical hysterectomy (RH) for stage IA2-IB1 cervical cancer. DESIGN: Ⅱ-2: : Retrospective cohort study. SETTING: Shandong Cancer Hospital. PATIENTS: 329 patients with IA2-IB1 cervical cancer. INTERVENTIONS: All patients underwent radical abdominal trachelectomy (ART) or RH. MEASUREMENTS AND MAIN RESULTS: All patients were divided into ART (n=143) and RH (n=186) group according to surgical approach...
June 13, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29908329/the-incidence-of-vocal-fold-motion-impairment-after-primary-thyroid-and-parathyroid-surgery-for-a-single-high-volume-academic-surgeon-determined-by-pre-and-immediate-post-operative-fiberoptic-laryngoscopy
#9
Vaninder K Dhillon, Eleni Rettig, Salem I Noureldine, Dane J Genther, Ahmed Hassoon, Mai G Al Khadem, Ozan B Ozgursoy, Ralph P Tufano, Charles W Cummings
BACKGROUND: Vocal fold motion impairment (VFMI) is a well-recognized complication of thyroid and parathyroid surgery. Preoperative counseling requires a thorough understanding of the incidence, risk factors, and value of early diagnosis of postoperative VFMI. Our objective is to describe the incidence of and risk factors for VFMI for a single high-volume academic surgeon, and to assess the utility of immediate postoperative fiberoptic laryngoscopy (FOL) in early diagnosis of VFMI. METHODS: Retrospective cohort study of patients undergoing primary thyroid and parathyroid procedures by a single high-volume surgeon at an academic tertiary care center...
June 13, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29908324/pd-1-blockade-with-nivolumab-in-patients-with-recurrent-malignant-pleural-mesothelioma
#10
Josine Quispel-Janssen, Vincent van der Noort, Jeltje F de Vries, Marion Zimmerman, Ferry Lalezari, Erik Thunnissen, Kim Monkhorst, Robert Schouten, Laurel Schunselaar, Maria Disselhorst, Houke Klomp, Koen Hartemink, Sjaak Burgers, Wieneke Buikhuisen, Paul Baas
BACKGROUND: Malignant Pleural Mesothelioma (MPM) has limited treatment options and a poor outcome. PD-1/PD-L1 checkpoint inhibitors have proven efficacious in several cancer types. Nivolumab is a fully humanized monoclonal antibody against PD-1 with a favorable toxicity profile. In MPM, the immune system is considered to play an important role. We therefore tested nivolumab in recurrent MPM. METHODS: In this single center trial, patients with MPM received nivolumab 3mg/kg i...
June 13, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29908101/surgical-versus-non-surgical-treatment-of-actinic-cheilitis-a-systematic-review-and-meta-analysis
#11
REVIEW
Marianne de Vasconcelos Carvalho, Sandra Lúcia Dantas de Moraes, Cleidiel Aparecido Araujo Lemos, Joel Ferreira Santiago Júnior, Belmiro Cavalcanti do Egito Vasconcelos, Eduardo Piza Pellizzer
OBJECTIVE: The aim of this systematic review was to compare outcomes between surgical and non-surgical treatment of actinic cheilitis (AC). MATERIALS AND METHODS: A systematic review and meta-analysis based on the Preferred Reporting Items for Systematic reviews and Meta-Analyses guideline was performed. A search of PubMed/MEDLINE, Web of Science, and Cochrane Library databases was conducted. Articles were selected based on the inclusion criteria: randomized clinical trials, prospective/retrospective studies, and case series with at least 10 patients, with a minimum follow-up period of 6 months...
June 16, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29908068/macrophages-in-patients-with-recurrent-endometrial-polyps-could-exacerbate-th17-responses
#12
Yali Zhu, Zhihong Liu, Miaomiao Du, Lisha Yi, Guifang Gong, Xiang Tang
Endometrial polyps (EPs) are outgrowths in the endometrium with unknown etiology. The fact that EPs can often recur after surgical removal suggests that EPs are not induced by random events but by continuous or recurrent processes in the patients. We previously demonstrated that the risk of EP development was positively associated with overactive Th17 responses. However, the requirements of Th17 upregulation are yet unclear. Here, we recruited twenty-six females with symptomatic EP and twenty-four females without EP, and peripheral mononuclear cells were harvested for the examination of circulating immunity...
June 16, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29907964/evaluation-of-intralesional-injection-of-bleomycin-in-the-treatment-of-plantar-warts-clinical-and-dermoscopic-evaluation
#13
Manal T Barkat, Rasha T A Abdel-Aziz, Mervat S Mohamed
BACKGROUND: Treatment of plantar warts is difficult and requires multiple treatments, and they are more refractory to treatment than common warts. Intralesional bleomycin has been used in the treatment of warts with varying degrees of success. AIM: The aim of the present work is to evaluate the efficacy of intralesional injection of bleomycin in the treatment of plantar warts based on clinical and dermoscopic observations. PATIENTS AND METHODS: Bleomycin (1 mg/ml) was injected intralesionally into the pared plantar wart every 2 weeks for a maximum of four sessions...
June 15, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29907956/combined-fractional-carbon-dioxide-laser-and-long-pulsed-neodymium-yttrium-aluminium-garnet-1064-nm-laser-in-treatment-of-hidradenitis-suppurativa-a-prospective-randomized-intra-individual-controlled-study
#14
Amira A Abdel Azim, Rania T Salem, Rania Abdelghani
BACKGROUND: Multiple treatment modalities were introduced for treatment of hidradenitis suppurativa (HS) but mostly with unsatisfactory results. OBJECTIVE: In this prospective randomized right-left intra-individual controlled study, we studied the safety and efficacy of combined treatment with fractional CO2 laser and long pulsed Nd : YAG (1064 nm) laser in treatment of HS. METHODS: Twenty adult patients with HS were randomized into this study...
June 16, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29907945/neoadjuvant-proton-beam-irradiation-vs-adjuvant-ruthenium-brachytherapy-in-transscleral-resection-of-uveal-melanoma
#15
Alexander Böker, Daniel Pilger, Dino Cordini, Ira Seibel, Aline I Riechardt, Antonia M Joussen, Nikolaos E Bechrakis
BACKGROUND: Uveal melanoma is the most common primary ocular malignancy in adults in the USA and Europe. The optimal treatment of large uveal melanoma is still under debate. Radiation therapy has its limitation due its eye-threatening secondary complications and is therefore often combined with surgical excision of the tumor. METHODS: In a retrospective interventional review, we evaluated in total 242 patients with uveal melanoma that underwent transscleral tumor resection with a predefined protocol, either with adjuvant ruthenium brachytherapy (Ru-106 group, n 136,), or with neoadjuvant proton beam therapy (PBT group, n 106)...
June 16, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29907942/distribution-of-21-gene-recurrence-scores-in-male-breast-cancer-in-the-united-states
#16
Ariella M Altman, Scott Kizy, Jianling Yuan, Jason W Denbo, Eric H Jensen, Jane Y C Hui, Todd M Tuttle, Schelomo Marmor
BACKGROUND: The 21-gene recurrence score (RS) is a RT-PCR assay estimating risk of distant recurrence in estrogen receptor positive (ER+), human epidermal growth factor receptor 2 negative (HER2) breast cancer (BC). Studies validating RS are limited to women. Our objective was to assess RS distribution and factors associated with high-risk RS in male BC. METHODS: Using the Surveillance, Epidemiology, and End Results database, we identified men and women with ER+/HER2- BC from 2010 to 2013...
June 15, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29907940/infection-and-recurrence-rates-of-the-c-qur-v-patch-%C3%A2-in-ventral-hernia-repairs
#17
D Cheng, L Bonato, C Leinkram
PURPOSE: Ventral hernias are a common surgical issue and a myriad of surgical mesh designs has been developed for their treatment. Many of these new mesh designs have not been extensively tested and their complications rates are largely unknown. The C-QUR V-Patch Mesh™ combines a unique knit construction polypropylene mesh with an omega-3 fatty acid coating. There has only previously been one reported study investigating this mesh. METHODS: A multicentre cohort study, with a single surgeon, of 168 consecutive patients with ventral hernias underwent repair using a standardized open pre-peritoneal approach with the novel C-QUR V-Patch Mesh™ between January 2013 and June 2015...
June 15, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29907864/bladder-cancer-recurrence-surveillance-by-urine-metabolomics-analysis
#18
A Loras, M Trassierra, D Sanjuan-Herráez, M C Martínez-Bisbal, J V Castell, G Quintás, J L Ruiz-Cerdá
Non Muscle Invasive Bladder Cancer (NMIBC) is among the most frequent malignant cancers worldwide. NMIBC is treated by transurethral resection of the bladder tumor (TURBT) and intravesical therapies, and has the highest recurrence rate among solid tumors. It requires a lifelong patient monitoring based on repeated cystoscopy and urinary cytology, both having drawbacks that include lack of sensitivity and specificity, invasiveness and care costs. We conducted an investigative clinical study to examine changes in the urinary metabolome of NMBIC patients before and after TURBT, as well during the subsequent surveillance period...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907814/the-germline-mutational-landscape-of-brca1-and-brca2-in-brazil
#19
Edenir Inêz Palmero, Dirce Maria Carraro, Barbara Alemar, Miguel Angelo Martins Moreira, Ândrea Ribeiro-Dos-Santos, Kiyoko Abe-Sandes, Henrique Campos Reis Galvão, Rui Manuel Reis, Cristiano de Pádua Souza, Natalia Campacci, Maria Isabel Achatz, Rafael Canfield Brianese, Maria Nirvana da Cruz Formiga, Fabiana Baroni Makdissi, Fernando Regla Vargas, Anna Cláudia Evangelista Dos Santos, Hector N Seuanez, Kelly Rose Lobo de Souza, Cristina B O Netto, Patrícia Santos-Silva, Gustavo Stumpf da Silva, Rommel M R Burbano, Sidney Santos, Paulo Pimentel Assumpção, Izabel Maria Monteiro Bernardes, Taisa Manuela Bonfim Machado-Lopes, Thais Ferreira Bomfim, Maria Betânia Pereira Toralles, Ivana Nascimento, Bernardo Garicochea, Sergio D Simon, Simone Noronha, Fernanda Teresa de Lima, Anisse Marques Chami, Camila Matzenbacher Bittar, Jose Bines, Osvaldo Artigalas, Maria Del Pilar Esteves-Diz, Tirzah Braz Petta Lajus, Ana Carolina Leite Vieira Costa Gifoni, Rodrigo S C Guindalini, Terezinha Sarquis Cintra, Ida V D Schwartz, Pricila Bernardi, Diego Miguel, Sonia Tereza Dos Santos Nogueira, Josef Herzog, Jeffrey N Weitzel, Patricia Ashton-Prolla
The detection of germline mutations in BRCA1 and BRCA2 is essential to the formulation of clinical management strategies, and in Brazil, there is limited access to these services, mainly due to the costs/availability of genetic testing. Aiming at the identification of recurrent mutations that could be included in a low-cost mutation panel, used as a first screening approach, we compiled the testing reports of 649 probands with pathogenic/likely pathogenic variants referred to 28 public and private health care centers distributed across 11 Brazilian States...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907796/a-recurrent-de-novo-missense-pathogenic-variant-in-smarcb1-causes-severe-intellectual-disability-and-choroid-plexus-hyperplasia-with-resultant-hydrocephalus
#20
Illja J Diets, Trine Prescott, Neena L Champaigne, Grazia M S Mancini, Bård Krossnes, Radek Frič, Kristina Kocsis, Marjolijn C J Jongmans, Tjitske Kleefstra
PURPOSE: SMARCB1 encodes a subunit of the SWI/SNF complex involved in chromatin remodeling. Pathogenic variants (PV) in this gene can give rise to three conditions. Heterozygous loss-of-function germline PV cause rhabdoid tumor predisposition syndrome and schwannomatosis. Missense PV and small in-frame deletions in exons 8 and 9 result in Coffin-Siris syndrome, which is characterized by intellectual disability (ID), coarse facial features, and fifth digit anomalies. METHODS: By a gene matching approach, individuals with a similar SMARCB1 PV were identified...
June 15, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
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