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https://www.readbyqxmd.com/read/28945028/-effects-of-methyl-jasmonate-on-accumulation-of-furanocoumarins-in-changium-smyrnioides-and-its-suspension-cells
#1
Jing Cai, Yun Ma, Jian-Wei Chen, Xiang Li, Ping Zhou
Changium smyrnioides is an endangered and endemic medicinal herb in China which contains rich furanocoumarins. Bergaptol, bergapten and xanthotoxin are natural furanocoumarins in Ch. smyrnioides, among which bergaptol is mainly contained in in vitro cultures while the latter ones distribute in all organs and cultures of the plant. In this study, methyl jasmonate was used to elicit furanocoumarins in both cultivated plant and suspension cells. The accumulations of biomass and 3 furanocoumarins as well as the activity of cell, phenylalanine ammonia-lyase and antioxidase were detected...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28945021/-progress-of-new-antidepressant-drugs-development
#2
REVIEW
Xiao Zhang, Jun-Sheng Tian, Huan Liu, Xue-Mei Qin
Depression becomes more and more serious and has been greatly do harm to human's physical and mental health. WHO predicts that depression will become the second leading cause of abnormal death and disability by 2020. There is still the drug treatment as the first-line antidepressive therapy, but the effect of listed antidepressant drugs is not ideal. Therefore, discovery of new antidepressant drug of sunique, higher curative effect, less adverse reaction is the pursuit of pharmaceutical. The traditional Chinese medicine (TCM) of anti-depression and natural antidepressant in currently listed, drug development and drug discovery phase are summarized in this paper, aiming to provide reference for new antidepressant drug research...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28944956/ethical-challenges-in-biomarker-driven-drug-development
#3
Spencer Phillips Hey
The increasing importance of biomarkers-as drivers of research and drug development activity, surrogate outcomes in clinical trials, and the centerpiece of precision medicine-raises many new ethical challenges. In what follows, I briefly review some of the major ethical challenges and debates already identified in the literature, and then describe a new ethical challenge that arises from the abstract nature of biomarker hypotheses.
September 25, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28944749/keeping-communications-flowing-during-large-scale-disasters-leveraging-amateur-radio-innovations-for-disaster-medicine
#4
Victor H Cid, Andrew R Mitz, Stacey J Arnesen
Medical facilities may struggle to maintain effective communications during a major disaster. Natural and man-made disasters threaten connectivity by degrading or crippling Internet, cellular/mobile, and landline telephone services across wide areas. Communications among staff, between facilities, and to resources outside the disaster area may be lost for an extended time. A prototype communications system created by the National Library of Medicine (NLM) provides basic communication services that ensure essential connectivity in the face of widespread infrastructure loss...
September 25, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28944552/an-av-rgd-integrin-inhibitor-toolbox-drug-discovery-insight-challenges-and-opportunities
#5
Richard Hatley, Simon Macdonald, Robert Slack, Joelle Le, Steve Ludbrook, Pauline Lukey
There is a requirement for efficacious and safe medicines to treat diseases with high unmet need. The resurgence in av RGD integrin inhibitor drug discovery is poised to contribute to this requirement. However, drug discovery in the av integrin space is notoriously difficult due to the receptors being structurally very similar as well as the polar zwitterionic nature of the pharmacophore. This review aims to guide drug discovery research in this field through an av inhibitor toolbox, consisting of small molecules and antibodies...
September 25, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28943439/a-homogalacturonan-from-hippophae-rhamnoides-l-berries-enhance-immunomodulatory-activity-through-tlr4-myd88-pathway-mediated-activation-of-macrophages
#6
Hailiang Wang, Hongtao Bi, Tingting Gao, Bin Zhao, Weihua Ni, Jun Liu
Our previous study isolated a natural high-methoxyl homogalacturonan (HRWP-A) from Hippophae rhamnoides and showed antitumor activity in vivo. In this study, the immunomodulatory activity and mechanisms of action of HRWP-A were further investigated. RESULTS: showed that HRWP-A could recover the body condition and activated macrophage in Cyclophosphamide (CTX)-induced immunosuppressed mice. Further, we investigated the possible mechanism underlying the effects of HRWP-A on mouse peritoneal macrophages...
September 21, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28942821/medicinal-plant-products-targeting-quorum-sensing-for-combating-bacterial-infections
#7
REVIEW
Abdelhakim Bouyahya, Nadia Dakka, Abdeslam Et-Touys, Jamal Abrini, Youssef Bakri
Traditional treatment of infectious diseases is based on compounds that aim to kill or inhibit bacterial growth. The bacterial resistance against antibiotics is a serious issue for public health. Today, new therapeutic targets other than the bacterial wall were deciphered. Quorum sensing or bacterial pheromones are molecules called auto-inducer secreted by bacteria to regulate some functions such as antibiotic resistance and biofilms formation. This therapeutic target is well-studied worldwide, nevertheless the scientific data are not updated and only recent researches started to look into its potential as a target to fight against infectious diseases...
August 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28942135/a-medicinal-plant-compound-capnoidine-prevents-the-onset-of-inflammation-in-a-mouse-model-of-colitis
#8
Catherine Shepherd, Paul Giacomin, Severine Navarro, Catherine Miller, Alex Loukas, Phurpa Wangchuk
ETHNOPHARMACOLOGICAL RELEVANCE: The traditional uses of Corydalis dubia, Ajania nubigena and Pleurospermum amabile in the Bhutanese traditional medicine for treating disorders related to inflammatory conditions and the in vitro anti-inflammatory activity of their crude extracts inspired the isolation and the investigation of anticolitic properties of four pure compounds. MATERIALS AND METHODS: Three medicinal plants were collected from Himalayan Mountains of Bhutan...
September 20, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28942036/polysaccharides-isolated-from-hedyotis-diffusa-inhibits-the-aggressive-phenotypes-of-laryngeal-squamous-carcinoma-cells-via-inhibition-of-bcl-2-mmp-2-and-%C3%AE-pa
#9
Caiqin Wu, Huanan Luo, Weijun Ma, Xiaoyong Ren, Chuangxin Lu, Ni Li, Zhenghui Wang
Hedyotis diffusa, a traditional Chinese herbal medicine, possesses anti-cancer, anti-oxidative, and anti-inflammatory effects. The aim of this study is to explore the anti-tumor potential of Hedyotis diffusa polysaccharides (HDP) in human larynx squamous carcinoma. High performance size-exclusion chromatography analysis indicated the homogeneous nature of HDP. Total carbohydrate content in HDP was 97.3%, without contamination of protein and nucleic acid. HDP suppressed the proliferation of Hep2 human larynx squamous carcinoma cells in a time- and dose-dependent manner...
September 20, 2017: Gene
https://www.readbyqxmd.com/read/28941580/immunoglobulins-benefits-and-risks-from-the-patient-s-point-of-view
#10
Bruno Revol, Laura Bickert, Françoise Sarrot-Reynauld, Benoit Allenet
Patients have to be informed about the risks and benefits of medicinal products derived from human plasma. No study has examined the patient's perspective yet. Our objective was to assess perceived benefits and risks of immunoglobulins administration from the patient's point of view. Thirty-four patients receiving subcutaneous or intravenous immunoglobulins for chronic disorders at a single university hospital were asked to complete a survey. Although the level of comfort was high, the results revealed variable and incomplete knowledge, in particular about the nature of the treatment...
July 31, 2017: Thérapie
https://www.readbyqxmd.com/read/28940105/experimental-and-theoretical-studies-of-emodin-interacting-with-a-lipid-bilayer-of-dmpc
#11
REVIEW
Antonio R da Cunha, Evandro L Duarte, Hubert Stassen, M Teresa Lamy, Kaline Coutinho
Emodin is one of the most abundant anthraquinone derivatives found in nature. It is the active principle of some traditional herbal medicines with known biological activities. In this work, we combined experimental and theoretical studies to reveal information about location, orientation, interaction and perturbing effects of Emodin on lipid bilayers, where we have taken into account the neutral form of the Emodin (EMH) and its anionic/deprotonated form (EM(-)). Using both UV/Visible spectrophotometric techniques and molecular dynamics (MD) simulations, we showed that both EMH and EM(-) are located in a lipid membrane...
September 22, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28939278/engineering-the-biocatalytic-selectivity-of-iridoid-production-in-saccharomyces-cerevisiae
#12
John M Billingsley, Anthony B DeNicola, Joyann S Barber, Man-Cheng Tang, Joe Horecka, Angela Chu, Neil K Garg, Yi Tang
Monoterpene indole alkaloids (MIAs) represent a structurally diverse, medicinally essential class of plant derived natural products. The universal MIA building block strictosidine was recently produced in the yeast Saccharomyces cerevisiae, setting the stage for optimization of microbial production. However, the irreversible reduction of pathway intermediates by yeast enzymes results in a non-recoverable loss of carbon, which has a strong negative impact on metabolic flux. In this study, we identified and engineered the determinants of biocatalytic selectivity which control flux towards the iridoid scaffold from which all MIAs are derived...
September 19, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/28939231/counter-current-chromatography-with-off-line-detection-by-ultra-high-performance-liquid-chromatography-high-resolution-mass-spectrometry-in-the-study-of-the-phenolic-profile-of-lippia-origanoides
#13
Suzana Guimaraes Leitão, Gilda Guimarães Leitão, Douglas K T Vicco, João Paulo Barreto Pereira, Gustavo de Morais Simão, Danilo R Oliveira, Rita Celano, Luca Campone, Anna Lisa Piccinelli, Luca Rastrelli
Lippia origanoides (Verbenaceae) is an important Brazilian medicinal plant, also used for culinary purposes. Most chemical studies with this plant have been focused on its volatile composition. In this work, we combined High-Speed Counter-current Chromatography (HSCCC) and High Performance Liquid Chromatography coupled to Ultra Violet detection and High Resolution Mass Spectrometry (HPLC-UV-HRMS(n)) methodologies to access the non-volatile chemical composition of L. origanoides. The crude ethanol extract of L...
September 6, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28939181/new-light-for-phytochemicals
#14
Jarmo K Holopainen, Minna Kivimäenpää, Riitta Julkunen-Tiitto
Light-emitting diode (LED) lighting technology with narrow-bandwidth illumination helps to reduce energy consumption on covered crops. Here, we discuss how this new technology, which provides flexible modification of light spectra, will open new avenues for natural modulation of medicinal and crop plant metabolomes for better colour, flavour, fragrance, and antioxidant properties.
September 19, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28938946/identification-of-a-protective-proteomic-signature-and-a-potential-therapeutic-target-in-diabetic-nephropathy
#15
Nicholas Chun, Christina M Wyatt, John C He
In a recent paper in Nature Medicine, Qi et al. set out to identify protective pathways in patients with longstanding diabetes who do not develop diabetic nephropathy. Unbiased proteomic analysis of kidney tissue identified a unique protein signature in unaffected individuals. Studies in vitro and in murine models identified the highly upregulated glycolytic enzyme pyruvate kinase M2 as a potential therapeutic target to prevent or treat diabetic nephropathy.
October 2017: Kidney International
https://www.readbyqxmd.com/read/28938642/facile-total-synthesis-of-lysicamine-and-the-anticancer-activities-of-the-ru-ii-rh-iii-mn-ii-and-zn-ii-complexes-of-lysicamine
#16
Jiao-Lan Qin, Ting Meng, Zhen-Feng Chen, Xiao-Li Xie, Qi-Pin Qin, Xiao-Ju He, Ke-Bin Huang, Hong Liang
Lysicamine is a natural oxoaporphine alkaloid, which isolated from traditional Chinese medicine (TCM) herbs and has been shown to possess cytotoxicity to hepatocarcinoma cell lines. Reports on its antitumor activity are scarce because lysicamine occurs in plants at a low content. In this work, we demonstrate a facile concise total synthesis of lysicamine from simple raw materials under mild reaction conditions, and the preparation of the Ru(II), Rh(III), Mn(II) and Zn(II) complexes 1-4 of lysicamine (LY). All the compounds were fully characterized by elemental analysis, IR, ESI-MS, (1)H and (13)C NMR, as well as single-crystal X-ray diffraction analysis...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938517/green-tea-camellia-sinensis-and-l-theanine-medicinal-values-and-beneficial-applications-in-humans-a-comprehensive-review
#17
REVIEW
Muhammad Saeed, Muhammad Naveed, Muhammad Arif, Mohib Ullah Kakar, Robina Manzoor, Mohamed Ezzat Abd El-Hack, Mahmoud Alagawany, Ruchi Tiwari, Rekha Khandia, Ashok Munjal, Kumaragurubaran Karthik, Kuldeep Dhama, Hafiz M N Iqbal, Maryam Dadar, Chao Sun
Green tea (Camellia sinensis) is a famous herb, and its extract has been extensively used in traditional Chinese medicinal system. In this context, several studies have revealed its health benefits and medicinal potentialities for several ailments. With ever increasing scientific knowledge, search for safer, potential and novel type of health-related supplements quest, scientists are re-directing their research interests to explore natural resources i.e. medicinal herbs/plant derived compounds. Green tea consumption has gained a special attention and popularity in the modern era of changing lifestyle...
September 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28936618/defining-and-measuring-diagnostic-uncertainty-in-medicine-a-systematic-review
#18
Viraj Bhise, Suja S Rajan, Dean F Sittig, Robert O Morgan, Pooja Chaudhary, Hardeep Singh
BACKGROUND: Physicians routinely encounter diagnostic uncertainty in practice. Despite its impact on health care utilization, costs and error, measurement of diagnostic uncertainty is poorly understood. We conducted a systematic review to describe how diagnostic uncertainty is defined and measured in medical practice. METHODS: We searched OVID Medline and PsycINFO databases from inception until May 2017 using a combination of keywords and Medical Subject Headings (MeSH)...
September 21, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28935631/cultural-crossings-of-care-an-appeal-to-the-medical-humanities
#19
Julia Kristeva, Marie Rose Moro, John Ødemark, Eivind Engebretsen
Modern medicine is confronted with cultural crossings in various forms. In facing these challenges, it is not enough to simply increase our insight into the cultural dimensions of health and well-being. We must, more radically, question the conventional distinction between the 'objectivity of science' and the 'subjectivity of culture'. This obligation creates an urgent call for the medical humanities but also for a fundamental rethinking of their grounding assumptions.Julia Kristeva (JK) has problematised the biomedical concept of health through her reading of the anthropogony of Cura (Care), who according to the Roman myth created man out of a piece of clay...
September 21, 2017: Medical Humanities
https://www.readbyqxmd.com/read/28935552/natural-products-applied-against-hydatid-cyst-protoscolices-a-review-of-past-to-present
#20
REVIEW
Mohammad Hasan Kohansal Koshki, Abbasali Nourian, Mohammad Taghi Rahimi, Ahmad Daryani, Adel Spotin, Ehsan Ahmadpour
Echinococcus granulosus is the causative agent of cystic echinococcosis (CE), which is distributed all around the world. CE is one of the most important global parasitic infectious diseases, both in humans and animals. This parasite causes hydatid cysts that can be lodge at different organs of host such as liver, lung even in heart and brain which may lead to death. Presently, numerous scolicidal chemical agents have been administrated for inactivation of the hydatid cyst contents. Because of increasing resistance and adverse effects of medications include abnormalities of liver function, abdominal pain, diarrhea, nausea, vomiting, dizziness, and headache; there is a need to find alternative therapies either with the least or without side effects...
September 18, 2017: Acta Tropica
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