keyword
MENU ▼
Read by QxMD icon Read
search

Overdiagnosis

keyword
https://www.readbyqxmd.com/read/28925663/top-poems-of-2016-consistent-with-the-principles-of-the-choosing-wisely-campaign
#1
Roland Grad, Mark H Ebell
A challenge in the Choosing Wisely campaign is to identify low-value clinical actions supported by high-quality evidence. We applied a method based on crowdsourcing the Daily POEM (patient-oriented evidence that matters) to identify low-value clinical actions from research studies consistent with the principles of Choosing Wisely. In 2016, we analyzed an average of 1,382 questionnaires on 265 unique POEMs delivered to physician members of the Canadian Medical Association. From these questionnaires, we identified the POEMs ranking highest on one questionnaire item directly linked to reducing overdiagnosis or overtreatment...
August 15, 2017: American Family Physician
https://www.readbyqxmd.com/read/28924688/the-barrier-to-informed-choice-in-cancer-screening-statistical-illiteracy-in-physicians-and-patients
#2
Odette Wegwarth, Gerd Gigerenzer
An efficient health care requires both informed doctors and patients. Our current healthcare system falls short on both counts. Most doctors and patients do not understand the available medical evidence. To illustrate the extent of the problem in the setting of cancer screening: In a representative sample of some 5000 women in nine European countries, 92% overestimated the reduction of breast cancer mortality by mammography by a factor of 10-200, or did not know. For a similar sample of about 5000 men with respect to PSA screening, this number was 89%...
2018: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/28914565/reducing-overdiagnosis-in-primary-care-is-needed
#3
Carl Llor
No abstract text is available yet for this article.
December 2017: European Journal of General Practice
https://www.readbyqxmd.com/read/28901600/ethical-issues-raised-by-thyroid-cancer-overdiagnosis-a-matter-for-public-health
#4
Wendy A Rogers, Wendy L Craig, Vikki A Entwistle
Current practices of identifying and treating small indolent thyroid cancers constitute an important but in some ways unusual form of overdiagnosis. Overdiagnosis refers to diagnoses that generally harm rather than benefit patients, primarily because the diagnosed condition is not a harmful form of disease. Patients who are overdiagnosed with thyroid cancer are harmed by the psycho-social impact of a cancer diagnosis, as well as treatment interventions such partial or total thyroidectomy, lifelong thyroid replacement hormone, monitoring, surgical complications and other side effects...
October 2017: Bioethics
https://www.readbyqxmd.com/read/28900493/a-multi-center-prospective-study-to-validate-an-algorithm-using-urine-and-plasma-biomarkers-for-predicting-gleason-%C3%A2-3-4-prostate-cancer-on-biopsy
#5
Maher Albitar, Wanlong Ma, Lars Lund, Babak Shahbaba, Edward Uchio, Soren Feddersen, Donald Moylan, Kirk Wojno, Neal Shore
Background: Unnecessary biopsies and overdiagnosis of prostate cancer (PCa) remain a serious healthcare problem. We have previously shown that urine- and plasma-based prostate-specific biomarkers when combined can predict high grade prostate cancer (PCa). To further validate this test, we performed a prospective multicenter study recruiting patients from community-based practices. Patients and Methods: Urine and plasma samples from 2528 men were tested prospectively. Results were correlated with biopsy findings, if a biopsy was performed as deemed necessary by the practicing urologist...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28899412/the-effect-of-information-about-the-benefits-and-harms-of-mammography-on-women-s-decision-making-study-protocol-for-a-randomized-controlled-trial
#6
Misericòrdia Carles, Montserrat Martínez-Alonso, Anna Pons, Maria José Pérez-Lacasta, Lilisbeth Perestelo-Pérez, Maria Sala, Carmen Vidal, Montse Garcia, Ana Toledo-Chávarri, Núria Codern, Maria Feijoo-Cid, Anabel Romero, Roger Pla, Jorge Soler-González, Xavier Castells, Montserrat Rué
BACKGROUND: The decision to participate or not in breast cancer screening is complex due to the trade-off between the expected benefit of breast cancer mortality reduction and the major harm of overdiagnosis. It seems ethically necessary to inform women so that they can actively participate in decision-making and make an informed choice based on their values and preferences. The objective of this study is to assess the effects of receiving information about the benefits and harms of screening on decision-making, in women approaching the age of invitation to mammography screening...
September 12, 2017: Trials
https://www.readbyqxmd.com/read/28898991/defining-papillary-carcinoma-of-the-thyroid-a-short-review-and-analysis
#7
Robin T Vollmer
Objectives: To review how changes in the pathologic definitions for papillary tumors of the thyroid during recent decades have affected outcomes for patients with these tumors. Methods: Forty-nine previous reports or studies involving collectively 53,606 patients were reviewed, and new analyses were performed on the data to include analyses of agreement, incidence, survival, and diagnostic categories. Results: The past emphasis on cytologic features to define papillary tumors has not resulted in ideal pairwise agreement between pathologists and has produced incidence and survival data suggesting overdetection and overdiagnosis...
August 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28894698/paradigm-shift-toward-reducing-overtreatment-of-ductal-carcinoma-in-situ-of-breast
#8
REVIEW
Yasuaki Sagara, Wong Julia, Mehra Golshan, Masakazu Toi
The prevalence of ductal carcinoma in situ (DCIS) of the breast has increased substantially after the introduction of breast cancer screening programs, although the clinical effects of early DCIS detection and treatment remain unclear. The standard treatment for DCIS has involved local breast-conserving surgery (BCS) followed by radiotherapy (RT) or total mastectomy with/without endocrine therapy, and the choice of local treatment is not usually based on clinicopathologic or biological factors. However, we have investigated the effectiveness of local treatment using breast surgery and RT using Surveillance, Epidemiology, and End Results data, and found that the effectiveness of breast surgery was modified by the nuclear grade...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28893765/requirement-for-cystatin-c-testing-in-chronic-kidney-disease-a-retrospective-population-based-study
#9
Daniel S Lasserson, Brian Shine, Christopher A O'Callaghan, Tim James
BACKGROUND: Creatinine-based estimated glomerular filtration rate (eGFR) determines chronic kidney disease (CKD) stage, but underestimates renal function. The 2014 updated guidance from the National Institute for Health and Care Excellence (NICE) recommends that GPs reduce overdiagnosis of CKD stage 3a (eGFR 45-60 ml/min/1.73 m(2)) by using the renal biomarker cystatin C. AIM: To determine the population requirement for cystatin C testing, compared with current national availability of the assay...
September 11, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28884617/strengths-and-gaps-in-physicians-risk-communication-a-scenario-study-of-the-influence-of-numeracy-on-cancer-screening-communication
#10
Dafina Petrova, Olga Kostopoulou, Brendan C Delaney, Edward T Cokely, Rocio Garcia-Retamero
OBJECTIVE: Many patients have low numeracy, which impedes their understanding of important information about health (e.g., benefits and harms of screening). We investigated whether physicians adapt their risk communication to accommodate the needs of patients with low numeracy, and how physicians' own numeracy influences their understanding and communication of screening statistics. METHODS: UK family physicians ( N = 151) read a description of a patient seeking advice on cancer screening...
September 1, 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/28866466/impact-of-clinical-guidelines-on-voiding-cystourethrogram-utilization-and-vesicoureteral-reflux-incidence
#11
Ted Lee, Chandy Ellimoottil, Kathryn A Marchetti, Tanima Banerjee, Vesna Ivančić, Kate H Kraft, David A Bloom, John M Park, Julian Wan
BACKGROUND: To prevent overdiagnosis and overtreatment of vesicoureteral reflux, the 2007 British National Institution of Clinical Excellence (NICE) and 2011 American Academy of Pediatrics (AAP) guidelines both recommended against routine voiding cystourethrogram in children presenting with first febrile urinary tract infections. The impact of these guidelines on clinical practice is unknown. METHODS: Using an administrative claims database (Cliniformatics(TM) Data Mart), children with voiding cystourethrogram or diagnosis of vesicoureteral reflux between 2001 and 2015 were identified...
August 30, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28863965/-utility-of-normality-low-limit-of-spirometry-in-diagnosed-copd-patients
#12
J C Naveiro-Rilo, S García García, L Flores-Zurutuza, L Carazo Fernández, C Domínguez Fernández, J L Palomo García
AIM: To evaluate the differences in COPD patients below the lower limit of normal (LLN) of the fixed ratio FEV1/FVC < 0.70 and those above this limit. PATIENTS AND METHODS: Cross-sectional study. COPD patients between 40 and 85 years old included in primary care clinical record database were randomly selected. Baseline and postbronchodilator spirometries were performed. Two groups of patients were established: FEV1/FVC<0.70 and ≤LIN (group1) and FEV/FVC<0...
August 29, 2017: Revista de Calidad Asistencial: Organo de la Sociedad Española de Calidad Asistencial
https://www.readbyqxmd.com/read/28860736/overdiagnosis-of-copd-in-hospitalized-patients
#13
Kerry Spero, Ghiath Bayasi, Linda Beaudry, Kimberly R Barber, Fahim Khorfan
BACKGROUND: The diagnosis of chronic obstructive pulmonary disease (COPD) is usually made based on history and physical exam alone. Symptoms of dyspnea, cough, and wheeze are nonspecific and attributable to a variety of diseases. Confirmatory testing to verify the airflow obstruction is available but rarely used, which may result in substantial misdiagnoses of COPD. The aim of this study is to evaluate the use of confirmatory testing and assess the accuracy of the diagnosis. METHODS: From January 2011 through December 2013, 6,018 patients with COPD as a principal or leading diagnosis were admitted at a community teaching hospital...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28857962/women-s-awareness-of-and-responses-to-messages-about-breast-cancer-overdiagnosis-and-overtreatment-results-from-a-2016-national-survey
#14
Rebekah H Nagler, Erika Franklin Fowler, Sarah E Gollust
BACKGROUND: Scientists, clinicians, and other experts aim to maximize the benefits of cancer screening while minimizing its harms. Chief among these harms are overdiagnosis and overtreatment. Although available data suggest that patient awareness of these harms is low, we know little about how patients respond to information about these phenomena. OBJECTIVES: Using the case of breast cancer screening, this study assesses women's awareness of and reactions to statements about overdiagnosis and overtreatment...
August 28, 2017: Medical Care
https://www.readbyqxmd.com/read/28843825/implementation-of-a-rapid-hit-immunoassay-at-a-university-hospital-retrospective-analysis-of-hit-laboratory-orders-in-patients-with-thrombocytopenia
#15
Anne Black, Susanne Heimerl, Linnéa Oertli, Wolf Wilczek, Andreas Greinacher, Michael Spannagl, Wolfgang Herr, Christina Hart
BACKGROUND: Heparin-induced thrombocytopenia (HIT) is a rare cause of thrombocytopenia and a potentially life-threatening adverse drug reaction. Clinical overdiagnosis of HIT results in costly laboratory tests and anticoagulation. Criteria and algorithms for diagnosis are established, but their translation into clinical practice is still challenging. STUDY DESIGN AND METHODS: In a retrospective approach we studied all HIT related laboratory test requests within four years and evaluated data before (1st period, 24month) and after (2nd period, 24month) replacing particle gel immunoassay (PaGIA) and enzyme-linked immunosorbent assay (ELISA) by a chemiluminescent immunoassay (CLIA)...
August 15, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28838313/trade-off-between-benefits-harms-and-economic-efficiency-of-low-dose-ct-lung-cancer-screening-a-microsimulation-analysis-of-nodule-management-strategies-in-a-population-based-setting
#16
Marina Treskova, Ines Aumann, Heiko Golpon, Jens Vogel-Claussen, Tobias Welte, Alexander Kuhlmann
BACKGROUND: In lung cancer screening, a nodule management protocol describes nodule assessment and thresholds for nodule size and growth rate to identify patients who require immediate diagnostic evaluation or additional imaging exams. The Netherlands-Leuvens Screening Trial and the National Lung Screening Trial used different selection criteria and nodule management protocols. Several modelling studies have reported variations in screening outcomes and cost-effectiveness across selection criteria and screening intervals; however, the effect of variations in the nodule management protocol remains uncertain...
August 25, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28828599/outcomes-for-women-with-minimal-volume-ductal-carcinoma-in-situ-completely-excised-at-core-biopsy
#17
Shirin Muhsen, Andrea V Barrio, Megan Miller, Cristina Olcese, Sujata Patil, Monica Morrow, Kimberly J Van Zee
BACKGROUND: Overdiagnosis and overtreatment of ductal carcinoma in situ (DCIS) are concerns, especially for women with low-volume, screen-detected DCIS. This study aimed to evaluate the outcomes for such patients. METHODS: Women who had minimal-volume DCIS (mDCIS, defined as DCIS diagnosed by core biopsy but with no residual disease on the surgical excision) treated with breast-conserving surgery from 1990 to 2011 were identified. Ipsilateral and contralateral breast events (IBE and CBE) were compared by competing-risk (CR) analysis...
August 21, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28827249/comparing-perceived-clarity-of-information-on-overdiagnosis-used-for-breast-and-prostate-cancer-screening-in-england-an-experimental-survey
#18
Alex Ghanouni, Cristina Renzi, Emily McBride, Jo Waller
OBJECTIVES: 'Overdiagnosis', detection of disease that would never have caused symptoms or death, is a public health concern due to possible psychological and physical harm but little is known about how best to explain it. This study evaluated public perceptions of widely used information on the concept to identify scope for improving communication methods. DESIGN: Experimental survey carried out by a market research company via face-to-face computer-assisted interviews...
August 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28822001/trends-in-stage-specific-breast-cancer-incidence-in-new-south-wales-australia-insights-into-the-effects-of-25%C3%A2-years-of-screening-mammography
#19
Gemma Jacklyn, Kevin McGeechan, Les Irwig, Nehmat Houssami, Stephen Morrell, Katy Bell, Alexandra Barratt
PURPOSE: Screening mammography aims to improve breast cancer (BC) prognosis by increasing the incidence of early-stage tumours in order to decrease the incidence of late-stage cancer, but no reports have investigated these potential effects in an Australian population. Therefore we aimed to identify temporal trends in stage-specific BC in New South Wales (NSW), Australia, between 1972 and 2012. METHODS: An observational study of women who received a diagnosis of BC from 1972-2012 as recorded in the NSW Cancer Registry, a population-based registry with almost complete coverage and high rates of histological verification...
August 19, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28818742/citrus-cervical-cancer-screening-trial-by-randomization-of-hpv-testing-intervention-for-upcoming-screening-design-methods-and-baseline-data-of-18-471-women
#20
Tohru Morisada, Katsuhiro Teramoto, Hirokuni Takano, Ikuko Sakamoto, Hiroshi Nishio, Takashi Iwata, Akihiko Hashi, Ryohei Katoh, Aikou Okamoto, Hiroshi Sasaki, Eiji Nakatani, Satoshi Teramukai, Daisuke Aoki
BACKGROUND: To assess the efficacy of screening with concurrent liquid-based cytology and human papillomavirus (HPV) testing for primary cervical cancer screening, we initiated a randomized trial entitled CervIcal cancer screening Trial by Randomization of HPV testing intervention for Upcoming Screening (CITRUS). METHODS: Between June 2013 and March 2015, women aged 30-64 years of age who participated in a regular cervical cancer screening program (every 2 years) were invited to enrollment of our study...
August 14, 2017: Cancer Epidemiology
keyword
keyword
206
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"