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Overdiagnosis

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https://www.readbyqxmd.com/read/27913545/what-have-we-learned-from-large-population-studies-of-von-willebrand-disease
#1
Robert R Montgomery, Veronica H Flood
Von Willebrand factor (VWF) is a critical regulator of hemostatic processes, including collagen binding, platelet adhesion, and platelet aggregation. It also serves as a carrier protein to normalize plasma factor VIII synthesis, release, and survival. While VWF protein measurements by immunoassay are reasonably comparable between institutions, the measurement of VWF ristocetin cofactor activity (VWF:RCo) has significant variability. Other tests of VWF function, including collagen binding or platelet glycoprotein IIb-IIIa binding, are not universally available, yet these functional defects may cause major bleeding even with normal VWF antigen (VWF:Ag) and VWF:RCo assays...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27903502/overdiagnosis-of-thyroid-cancer
#2
EDITORIAL
Louise Davies
No abstract text is available yet for this article.
November 30, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27897042/state-of-the-art-pulmonary-ct-angiography-for-acute-pulmonary-embolism
#3
Moritz H Albrecht, Matthew W Bickford, John W Nance, Longjiang Zhang, Carlo N De Cecco, Julian L Wichmann, Thomas J Vogl, U Joseph Schoepf
OBJECTIVE: Pulmonary CT angiography (CTA) is the imaging modality of choice in suspected acute pulmonary embolism (PE). Current pulmonary CTA techniques involve ever lower doses of contrast medium and radiation along with advanced postprocessing applications to enhance image quality, diagnostic accuracy, and provide added value in patient management. The objective of this article is to summarize these current developments and discuss the appropriate use of state-of-the-art pulmonary CTA...
November 29, 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27894707/missteps-in-current-estimates-of-cancer-overdiagnosis
#4
Christoph I Lee, Ruth Etzioni
The balance between the benefits and harms of imaging-based cancer screening continues to be an area of controversy and widespread media attention. Of the potential harms, overdiagnosis from screening is likely the most elusive in estimating and quantifying. This article describes the major methodological issues with recently reported estimates of overdiagnosis that are based on excess cancer incidence, and suggests that modeling focused on tumor lead-time can serve as a complementary method for excess incidence-based overdiagnosis estimates...
November 25, 2016: Academic Radiology
https://www.readbyqxmd.com/read/27888850/mr-imaging-of-the-pediatric-foot-and-ankle-what-does-normal-look-like
#5
REVIEW
Grace Mang Yuet Ma, Kirsten Ecklund
MR imaging is ideally suited for characterization of the soft tissue, cartilaginous, and osseous structures of the pediatric ankle. An understanding of the normal MR imaging appearance associated with the dynamic skeletal maturation process will prevent overdiagnosis and unnecessary treatment. In this article, we review the normal MR imaging appearance of the growing ankle as well as several disease processes unique to the pediatric population.
February 2017: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/27876036/diabetes-screening-intervals-based-on-risk-stratification
#6
Sachiko Ohde, Emily McFadden, Gautam A Deshpande, Hiroshi Yokomichi, Osamu Takahashi, Tsuguya Fukui, Rafael Perera, Zentaro Yamagata
BACKGROUND: Guidelines for frequency of Type 2 diabetes mellitus (DM) screening remain unclear, with proposed screening intervals typically based on expert opinion. This study aims to demonstrate that HbA1c screening intervals may differ substantially when considering individual risk for diabetes. METHODS: This was a multi-institutional retrospective open cohort study. Data were collected between April 1999 to March 2014 from one urban and one rural cohort in Japan...
November 22, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27871502/screening-for-abdominal-aortic-aneurysm-in-asymptomatic-adults
#7
REVIEW
Muhammad Usman Ali, Donna Fitzpatrick-Lewis, John Miller, Rachel Warren, Meghan Kenny, Diana Sherifali, Parminder Raina
BACKGROUND: This report was produced for the Canadian Task Force on Preventive Health Care to provide guidelines on screening for abdominal aortic aneurysm (AAA) with ultrasound scan. PURPOSE: The aim of this systematic review is to examine the evidence on benefits and harms of AAA screening. SEARCH STRATEGY: This systematic review considered studies from the most recent United States Preventive Services Task Force review on AAA screening and passed through the screening process with citations identified in our search up to April 2015 (PROSPERO Registration #CRD42015019047)...
December 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27866427/image-guided-thermal-ablation-might-be-a-way-to-compensate-for-image-deriving-cancer-overdiagnosis-author-reply
#8
Ji-Hoon Kim, Jung Hwan Baek, Jin Yong Sung, Dong Gyu Na
No abstract text is available yet for this article.
December 1, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27866424/image-guided-thermal-ablation-might-be-a-way-to-compensate-for-image-deriving-cancer-overdiagnosis
#9
Giovanni Mauri, Luca Maria Sconfienza
No abstract text is available yet for this article.
November 30, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27854006/mammography-an-update-of-the-eusobi-recommendations-on-information-for-women
#10
Francesco Sardanelli, Eva M Fallenberg, Paola Clauser, Rubina M Trimboli, Julia Camps-Herrero, Thomas H Helbich, Gabor Forrai
: This article summarises the information to be offered to women about mammography. After a delineation of the aim of early diagnosis of breast cancer, the difference between screening mammography and diagnostic mammography is explained. The need to bring images and reports from the previous mammogram (and from other recent breast imaging examinations) is highlighted. Mammography technique and procedure are described with particular attention to discomfort and pain experienced by a small number of women who undergo the test...
November 16, 2016: Insights Into Imaging
https://www.readbyqxmd.com/read/27853066/concentrations-of-immunoglobulin-g-antibodies-against-pertussis-toxin-does-not-decrease-over-a-long-period-of-time-in-japan
#11
Yumi Sakakibara, Yoshio Ohtani, Torahiko Jinta, Toshihide Fujie, Yasunari Miyazaki, Naohiko Inase, Ryoichi Saito, Miho Akaza, Tetsuo Sasano, Yuki Sumi
Objective Adult patients with pertussis rarely show typical symptoms, such as paroxysmal coughing, inspiratory "whoop", or post-tussive vomiting. While a culture is regarded as the gold standard for diagnosis, the sensitivity is very low. Therefore, the diagnosis of pertussis in adults in clinical practice is mostly based on single-sample serology using an enzyme-linked immunosorbent assay (ELISA) with the pertussis toxin antigen. Various cut-off values for the anti-pertussis toxin IgG (PT-IgG) have been proposed...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27848107/defining-disease-in-the-context-of-overdiagnosis
#12
Mary Jean Walker, Wendy Rogers
Recently, concerns have been raised about the phenomenon of 'overdiagnosis', the diagnosis of a condition that is not causing harm, and will not come to cause harm. Along with practical, ethical, and scientific questions, overdiagnosis raises questions about our concept of disease. In this paper, we analyse overdiagnosis as an epistemic problem and show how it challenges many existing accounts of disease. In particular, it raises questions about conceptual links drawn between disease and dysfunction, harm, and risk...
November 15, 2016: Medicine, Health Care, and Philosophy
https://www.readbyqxmd.com/read/27844260/breast-density-notification-legislation-and-breast-cancer-stage-at-diagnosis-early-evidence-from-the-seer-registry
#13
Ilana Richman, Steven M Asch, Eran Bendavid, Jay Bhattacharya, Douglas K Owens
BACKGROUND: Twenty-eight states have passed breast density notification laws, which require physicians to inform women of a finding of dense breasts on mammography. OBJECTIVE: To evaluate changes in breast cancer stage at diagnosis after enactment of breast density notification legislation. DESIGN: Using a difference-in-differences analysis, we examined changes in stage at diagnosis among women with breast cancer in Connecticut, the first state to enact legislation, compared to changes among women in control states...
November 14, 2016: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/27842555/low-prevalence-of-laboratory-confirmed-malaria-in-clinically-diagnosed-adult-women-from-the-wakiso-district-of-uganda
#14
Sergey Yegorov, Ronald M Galiwango, Aloysious Ssemaganda, Moses Muwanga, Irene Wesonga, George Miiro, David A Drajole, Kevin C Kain, Noah Kiwanuka, Bernard S Bagaya, Rupert Kaul
BACKGROUND: The malaria burden in sub-Saharan Africa (SSA) has fallen substantially. Nevertheless, malaria remains a serious health concern, and Uganda ranks third in SSA in total malaria burden. Epidemiological studies of adult malaria in Uganda are scarce and little is known about rates of malaria in non-pregnant adult women. This pilot study assessed malaria prevalence among adult women from Wakiso district, historically a highly malaria endemic region. METHODS: Adult women using public health services were screened for malaria, HIV and pregnancy...
November 14, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27833967/diagnosing-hiv-associated-cerebral-diseases-the-importance-of-neuropathology-in-understanding-hiv
#15
Ioan Alexandru Diaconu, LaurenŢiu MihăiŢă Stratan, Luciana Nichita, Victoria Aramă, Valentina Ruxandra Moroti Constantinescu, Alexandra Ioana Diaconu, Daniela Adriana Ion
The study aims to compare two aspects concerning the diagnosis of acquired immune deficiency syndrome (AIDS)-associated central nervous system (CNS) pathology (neuroAIDS): clinical diagnoses issued ante mortem with pathology results issued post mortem. The group of 39 human immunodeficiency virus (HIV)-positive patients was created over 23 years and is limited by marked heterogeneity. The enrolled cases were treated at the "Prof. Dr. Matei Bals" National Institute for Infectious Diseases, Bucharest, Romania, deceased due to AIDS-related complications and underwent brain necropsies performed in the Pathology Laboratory at the "Colentina" Clinical Hospital, Bucharest...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27830773/grey-zones-in-cardiomyopathies-defining-boundaries-between-genetic-and-iatrogenic-disease
#16
REVIEW
Giovanni Quarta, Michael Papadakis, Paolo Di Donna, Niccolò Maurizi, Attilio Iacovoni, Antonello Gavazzi, Michele Senni, Iacopo Olivotto
Genetic cardiomyopathies are complex diseases with heterogeneous clinical presentation and phenotypes. Early descriptions of cardiomyopathies originated from case studies involving individuals with severe, paradigmatic presentation, which provided insight into the worst-case scenarios of these conditions. With time, improved diagnostic sensitivity and awareness of cardiomyopathies has uncovered a more heterogeneous disease spectrum, including mild phenotypes overlapping with physiological variation. This diagnostic 'grey area' poses important dilemmas, particularly in athletes...
November 10, 2016: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/27827846/age-related-renal-microvascular-changes-evaluation-by-three-dimensional-digital-imaging-of-the-human-renal-microcirculation-using-virtual-microscopy
#17
Noriko Uesugi, Yoshihito Shimazu, Kazunori Kikuchi, Michio Nagata
The renal microvasculature is targeted during aging, sometimes producing chronic kidney disease (CKD). Overdiagnosis of CKD in older persons is concerning. To prevent it, a new concept of "healthy aging" is arising from a healthy renal donor study. We investigated the renal microcirculatory changes of three older persons and compared them with that of one patient with nephrosclerosis using a three-dimensional (3D) reconstruction technique that we previously developed. This method uses a virtual slide system and paraffin-embedded serial sections of surgical material that was double-immunostained by anti-CD34 and anti-α smooth muscle actin (SMA) antibodies for detecting endothelial cells and medial smooth muscle cells, respectively...
November 2, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27814837/to-screen-or-not-to-screen-reconciling-individual-and-population-perspectives-on-screening
#18
REVIEW
L Rachid Salmi, Gaëlle Coureau, Marion Bailhache, Simone Mathoulin-Pélissier
Screening is the early detection of a latent disorder by a test to allow early intervention with the aim of improving prognosis. Individual and population perspectives on screening are perceived as opposing interests of patients and the population. In this article, we try to reconcile these perspectives. The individual perspective is based on the clinical experience of a better prognosis at early stages and patients with missed opportunities. In the population perspective, screening is based on a population-oriented, evidence-based model and addresses the acceptability and possible negative effects, including for people without the disorder...
November 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27814814/point-the-new-england-journal-of-medicine-article-suggesting-overdiagnosis-from-mammography-screening-is-scientifically-incorrect-and-should-be-withdrawn
#19
Daniel B Kopans
No abstract text is available yet for this article.
November 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27808149/editorial-reflux-and-laryngeal-symptoms-a-sea-of-confusion
#20
Michael F Vaezi
Chronic laryngeal symptoms are often attributed to gastroesophageal reflux disease based on nonspecific testing by laryngoscopy resulting in overdiagnosis of this condition. Identifying optimal means by which we can diagnose reflux in patients with chronic laryngeal symptoms is an unmet clinical area. One such technique might be measurement of oropharyngeal acid exposure employing a novel pH monitoring device. We outline the strengths and limitations of this new technology relative to the observational cohort study by Yadlapti et al...
November 2016: American Journal of Gastroenterology
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