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Elastic fibers and TIMP

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https://www.readbyqxmd.com/read/27528793/the-plant-derived-bauhinia-bauhinioides-kallikrein-proteinase-inhibitor-rbbki-attenuates-elastase-induced-emphysema-in-mice
#1
Bruno Tadeu Martins-Olivera, Rafael Almeida-Reis, Osmar Aparecido Theodoro-Júnior, Leandro Vilela Oliva, Natalia Neto Dos Santos Nunes, Clarice Rosa Olivo, Marlon Vilela de Brito, Carla Máximo Prado, Edna Aparecida Leick, Mílton de Arruda Martins, Maria Luiza Vilela Oliva, Renato Fraga Righetti, Iolanda de Fátima Lopes Calvo Tibério
Background. Elastase mediates important oxidative actions during the development of chronic obstructive pulmonary disease (COPD). However, few resources for the inhibition of elastase have been investigated. Our study evaluated the ability of the recombinant plant derived Bauhinia bauhinioides Kallikrein proteinase Inhibitor (rBbKI) to modulate elastase-induced pulmonary inflammation. Methods. C57Bl/6 mice were given intratracheal elastase (ELA group) or saline (SAL group) and were treated intraperitoneally with rBbKI (ELA-rBbKI and SAL-rBbKI groups)...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27296003/-expression-of-matrix-metalloproteinases-and-their-inhibitors-in-the-internal-carotid-artery-wall-in-pathological-tortuosity
#2
E M Pal'tseva, V O Polyakova, S A Oskolkova, A V Abramyan, A G Ivanova, Yu S Krylova, A V Gavrilenko
UNLABELLED: The principal morphological sign of fibromuscular dysplasia in pathological tortuosity (PT) of the internal carotid artery (ICA) is the fragmentation of elastic fibers that are degraded by matrix metalloproteinases 2 and 9 (MMP-2, MMP-9). Nevertheless, the role of MMPs and their inhibitors in the pathogenesis of ICA PT remains completely unexplored. AIM: to investigate the expression of elastin-degrading MMPs and their inhibitors in the wall of the ICA in PT by immunohistochemistry and confocal laser scanning microscopy...
May 2016: Arkhiv Patologii
https://www.readbyqxmd.com/read/26870168/mmp-1-2-and-timp-1-2-expression-levels-and-the-levels-of-collagenous-and-elastic-fibers-correlate-with-disease-progression-in-a-hamster-model-of-tongue-cancer
#3
Haixia Fan, Wenhao Jiang, Haixia Li, Ming Fang, Yudong Xu, Jinhua Zheng
In the present study, the presence of extracellular matrix components, including collagenous and elastic fibers, and the expression of their key regulating enzymes, were investigated in different stages of hamster tongue carcinoma development. Immunohistochemical and computer-assisted morphological analyses were performed to quantify the staining intensity and area (integral optical density) of matrix metalloproteinase (MMP)-1 and -2, tissue inhibitors of metalloproteinase (TIMP)-1 and -2, and the extent of elastic and collagenous fibers in histological sections...
January 2016: Oncology Letters
https://www.readbyqxmd.com/read/26537624/phloroglucinol-reduces-photodamage-in-hairless-mice-via-matrix-metalloproteinase-activity-through-mapk-pathway
#4
A-Rang Im, Kung-Woo Nam, Jin Won Hyun, Sungwook Chae
We investigated the photoprotective activity of phloroglucinol on ultraviolet B (UVB)-induced deleterious effects in hairless mice in vivo. To assess the photoprotective effect of phloroglucinol, phloroglucinol-treated HR-1 hairless male mice were exposed to UVB irradiation. The inhibitory activity of phloroglucinol on wrinkle formation was determined by analysis of skin replicas, epidermal thickness based on histological examination and collagen damage. Matrix metalloproteinase-1 (MMP-1), matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase (TIMP) mRNA levels were measured by real-time PCR...
January 2016: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/26122092/a-flavanone-from-baccharis-retusa-asteraceae-prevents-elastase-induced-emphysema-in-mice-by-regulating-nf-%C3%AE%C2%BAb-oxidative-stress-and-metalloproteinases
#5
Laura Taguchi, Nathalia M Pinheiro, Clarice R Olivo, Alessandra Choqueta-Toledo, Simone S Grecco, Fernanda D T Q S Lopes, Luciana C Caperuto, Mílton A Martins, Iolanda F L C Tiberio, Niels O Câmara, João Henrique G Lago, Carla M Prado
BACKGROUND: Pulmonary emphysema is characterized by irreversible airflow obstruction, inflammation, oxidative stress imbalance and lung remodeling, resulting in reduced lung function and a lower quality of life. Flavonoids are plant compounds with potential anti-inflammatory and antioxidant effects that have been used in folk medicine. Our aim was to determine whether treatment with sakuranetin, a flavonoid extracted from the aerial parts of Baccharis retusa, interferes with the development of lung emphysema...
June 30, 2015: Respiratory Research
https://www.readbyqxmd.com/read/25816137/pulmonary-inflammation-is-regulated-by-the-levels-of-the-vesicular-acetylcholine-transporter
#6
Nathalia M Pinheiro, Claudia J C P Miranda, Adenir Perini, Niels O S Câmara, Soraia K P Costa, Maria Isabel C Alonso-Vale, Luciana C Caperuto, Iolanda F L C Tibério, Marco Antônio M Prado, Mílton A Martins, Vânia F Prado, Carla M Prado
Acetylcholine (ACh) plays a crucial role in physiological responses of both the central and the peripheral nervous system. Moreover, ACh was described as an anti-inflammatory mediator involved in the suppression of exacerbated innate response and cytokine release in various organs. However, the specific contributions of endogenous release ACh for inflammatory responses in the lung are not well understood. To address this question we have used mice with reduced levels of the vesicular acetylcholine transporter (VAChT), a protein required for ACh storage in secretory vesicles...
2015: PloS One
https://www.readbyqxmd.com/read/25110559/protective-effect-of-the-standardized-green-tea-seed-extract-on-uvb-induced-skin-photoaging-in-hairless-mice
#7
Jae-Youn Lim, Ok-Kyung Kim, Jeongmin Lee, Min-Jae Lee, Namgil Kang, Jae-Kwan Hwang
BACKGROUND/OBJECTIVES: Ultraviolet B (UVB) irradiation on skin can induce production of reactive oxygen species (ROS), which cause expression of matrix metalloproteinases (MMPs) and collagen degradation. Thus, chronic exposure of skin to UVB irradiation leads to histological changes consistent with aging, such as wrinkling, abnormal pigmentation, and loss of elasticity. We investigated the protective effect of the standardized green tea seed extract (GSE) on UVB-induced skin photoaging in hairless mice...
August 2014: Nutrition Research and Practice
https://www.readbyqxmd.com/read/24035466/altered-vascular-activation-due-to-deficiency-of-the-nadph-oxidase-component-p22phox
#8
He Wang, Hassan Albadawi, Zakir Siddiquee, Jillian M Stone, Mikhail P Panchenko, Michael T Watkins, James R Stone
BACKGROUND: Reactive oxygen species generated by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase play important roles in vascular activation. The p22(phox) subunit is necessary for the activity of NADPH oxidase complexes utilizing Nox1, Nox2, Nox3, and Nox4 catalytic subunits. METHODS: We assessed p22(phox)-deficient mice and human tissue for altered vascular activation. RESULTS: Mice deficient in p22(phox) were smaller than their wild-type littermates but showed no alteration in basal blood pressure...
January 2014: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/23250987/akt2-confers-protection-against-aortic-aneurysms-and-dissections
#9
Ying H Shen, Lin Zhang, Pingping Ren, Mary T Nguyen, Sili Zou, Darrell Wu, Xing Li Wang, Joseph S Coselli, Scott A LeMaire
RATIONALE: Aortic aneurysm and dissection (AAD) are major diseases of the adult aorta caused by progressive medial degeneration of the aortic wall. Although the overproduction of destructive factors promotes tissue damage and disease progression, the role of protective pathways is unknown. OBJECTIVE: In this study, we examined the role of AKT2 in protecting the aorta from developing AAD. METHODS AND RESULTS: AKT2 and phospho-AKT levels were significantly downregulated in human thoracic AAD tissues, especially within the degenerative medial layer...
February 15, 2013: Circulation Research
https://www.readbyqxmd.com/read/23009745/effects-of-corticosteroid-montelukast-and-inos-inhibition-on-distal-lung-with-chronic-inflammation
#10
Flávia Castro Ribas Souza, Nathália Brandão Gobbato, Rafaela Guerra Maciel, Carla Máximo Prado, Mílton Arruda Martins, Edna A Leick, Iolanda F L Calvo Tibério
UNLABELLED: We evaluated the effects of anti-iNOS (1400W - W) associated with leukotriene antagonist (montelukast - M) or corticosteroid (dexamethasone - D) on distal lung of guinea pigs (GP) with chronic pulmonary inflammation. METHODS: GP were inhaled with ovalbumin (OVA-2×/week/4 weeks), treated with M (OVAM), D (OVAD) and/or W (OVAW, OVADW, OVAMW) and distal lungs were evaluated by morphometry. RESULTS: Isolated treatments were not sufficient to reduce all parameters...
January 15, 2013: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/22965799/overgrowth-with-increased-proliferation-of-fibroblast-and-matrix-metalloproteinase-activity-related-to-reduced-timp1-a-newly-recognized-syndrome
#11
Brian Chung, Aleksander Hinek, Sarah Keating, Rosanna Weksberg, Vibhuti Shah, Susan Blaser, Cynthia Hawkins, David Chitayat
We report on a child with prenatal onset of overgrowth associated with thick, excessive wrinkled skin and other abnormalities including cleft palate, Chiari malformation and polymicrogyria. His clinical features do not resemble any of the known reported overgrowth syndromes. Genetic evaluations, including karyotype, oligoarray, methylation-sensitive multiplex ligation-dependent probe amplification (MLPA) for 11p11.2 region, CDKN1C sequencing, GPC3 sequencing and dosage analysis, and HRAS sequencing, have been un-revealing...
October 2012: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/21719403/cutis-laxa-analysis-of-metalloproteinases-and-extracellular-matrix-expression-by-immunohistochemistry-and-histochemistry
#12
Weijie Gu, Wei Liu, Xueqin Yang, Xiaoying Yuan, Yan Tian, Rusong Meng, Qingli Zhao
Upregulation of matrix metalloproteinases (MMPs) and downregulation of tissue inhibitors of metalloproteinases (TIMP) have been reported in cultured fibroblasts from patients with congenital cutis laxa (CL) or anetoderma. We determined the protein expressions of MMP-1, MMP-2, MMP-3, MMP-9, MMP-12, TIMP-1 and collagen I, collagen III in vivo, to confirm their roles in the pathogenesis of cutis laxa. The protein expression of the MMPs and collagens from skin lesions of CL were detected by immunohistochemistry and analyzed by image analysis software...
September 2011: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/21585312/effects-of-inducible-nitric-oxide-synthase-inhibition-in-bronchial-vascular-remodeling-induced-by-chronic-allergic-pulmonary-inflammation
#13
Carla Máximo Prado, Larissa Yano, Guilherme Rocha, Claudia Miranda Starling, Vera Luíza Capelozzi, Edna Aparecida Leick-Maldonado, Mílton de Arruda Martins, Iolanda F Lopes Calvo Tibério
Vascular remodeling is an important feature in asthma pathophysiology. Although investigations suggested that nitric oxide (NO) is involved in lung remodeling, little evidence established the role of inducible NO synthase (iNOS) isoform in bronchial vascular remodeling. The authors investigated if iNOS contribute to bronchial vascular remodeling induced by chronic allergic pulmonary inflammation. Guinea pigs were submitted to ovalbumin exposures with increasing doses (1∼5 mg/mL) for 4 weeks. Animals received 1400W (iNOS-specific inhibitor) treatment for 4 days beginning at 7th inhalation...
June 2011: Experimental Lung Research
https://www.readbyqxmd.com/read/21126196/mechanisms-of-cardiovascular-remodeling-in-hyperhomocysteinemia
#14
REVIEW
Mesia M Steed, Suresh C Tyagi
In hypertension, an increase in arterial wall thickness and loss of elasticity over time result in an increase in pulse wave velocity, a direct measure of arterial stiffness. This change is reflected in gradual fragmentation and loss of elastin fibers and accumulation of stiffer collagen fibers in the media that occurs independently of atherosclerosis. Similar results are seen with an elevated level of homocysteine (Hcy), known as hyperhomocysteinemia (HHcy), which increases vascular thickness, elastin fragmentation, and arterial blood pressure...
October 1, 2011: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/21054198/effects-of-intense-pulsed-light-and-ultraviolet-a-on-metalloproteinases-and-extracellular-matrix-expression-in-human-skin
#15
Weijie Gu, Wei Liu, Xueqin Yang, Xiaozhong Zhao, Xiaoying Yuan, Huimin Ma, Yan Tian, Rusong Meng
OBJECTIVE: The aim of this study was to evaluate the effects of intense pulsed light (IPL) and ultraviolet A (UVA) irradiation on the expression of matrix metalloproteases (MMPs), tissue inhibitor of metalloproteinase 1 (TIMP-1), and extracellular matrix (ECM) in human skin, and to confirm the relative mechanism. BACKGROUND DATA: IPL has been widely used to treat photoaged skin but the underlying mechanism remains unknown. METHODS: Human buttock skin was irradiated by repetitive suberythemal doses of UVA and therapeutic doses of IPL...
February 2011: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/20889203/a-doxycycline-loaded-controlled-release-biodegradable-fiber-for-the-treatment-of-aortic-aneurysms
#16
A Yamawaki-Ogata, R Hashizume, M Satake, H Kaneko, S Mizutani, T Moritan, Y Ueda, Y Narita
The pathogenesis of aortic aneurysm (AA) is characterized by degradation of extracellular matrix with increased matrix metalloproteinases (MMPs) and inflammatory reaction. Doxycycline (DOXY) has been reported to control the extension of AA by regulation of MMP. However, systemic administration may cause adverse side effects. In this study, we demonstrated the possibility of local administration of DOXY controlled-release biodegradable fiber (DCRBF) for AA in mice. DCRBF was fabricated by biodegradable polymer (polylactic acid; PLA) mixed with DOXY using an electrospinning technique...
December 2010: Biomaterials
https://www.readbyqxmd.com/read/20621845/elevation-of-adam10-adam17-mmp-2-and-mmp-9-expression-with-media-degeneration-features-cacl2-induced-thoracic-aortic-aneurysm-in-a-rat-model
#17
Liang Geng, Wei Wang, Ying Chen, Jiumei Cao, Lin Lu, Qiujing Chen, Rumin He, Weifeng Shen
PURPOSE: This study was designed to establish a rat model of thoracic aortic aneurysm (TAA) by calcium chloride (CaCl(2))-induced arterial injury and to explore the potential role of a disintegrin and metalloproteinase (ADAM), matrix metalloproteinases (MMPs) and their endogenous inhibitors (TIMPs) in TAA formation. METHODS: Thoracic aorta of male Sprague-Dawley rats was exposed to 0.5M CaCl(2) or normal saline (NaCl). After 12weeks, animals were euthanized, and CaCl(2)-treated, CaCl(2)-untreated (n=12) and NaCl-treated aortic segments (n=12) were collected for histological and molecular assessments...
August 2010: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/20103929/overexpression-of-timp-2-mediated-by-recombinant-adenovirus-in-rat-abdominal-aorta-inhibits-extracellular-matrix-degradation
#18
Xin Zhao, Hailin Li, Jiahong Dong, Norihiro Kokudo, Wei Tang
To investigate the effects of a tissue inhibitor of the matrix metalloproteinase-2 (TIMP-2) gene on the extracellular matrix of the abdominal aorta, models of rat abdominal aortic aneurysm were utilized and a solution of AdTIMP-2 was perfused into the abdominal aorta. The models of rat abdominal aortic aneurysm were constructed with intraluminal perfusion of the abdominal aorta with porcine pancreatic elastase, and an adenovirus solution carrying the TIMP-2 gene was transferred into the aorta by local perfusion...
October 2008: Bioscience Trends
https://www.readbyqxmd.com/read/19115640/-progress-in-studies-on-effects-of-extracellular-matrix-in-occurrence-of-proliferative-vitreoretinopathy
#19
REVIEW
Liang-hai Wang, Gen-lin Li
It has been found that various extracellular matrix (ECM) probably play an important role in the occurrence of proliferative vitreoretinopathy (PVR), including structural proteins, adhesive proteins, anti-adhesive proteins, matrix metalloproteinase (MMP), and tissue inhibitor of MMP (TIMP) Structural proteins, including collagen and elastic fiber family, are the major non-cellular components of PVR membrane, and could promote contraction of membrane. Adhesive proteins, including fibronectin, vitronectin, laminin, could promote adhesion between cells and ECM in PVR, they promote the attachment, migration and differentiation of retinal pigment epithelium (RPE)...
August 2008: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/19009211/immunohistochemical-study-of-lung-remodeling-in-mice-exposed-to-cigarette-smoke
#20
Samuel Santos Valença, Luís Cristóvão Porto
OBJECTIVE: Various studies of emphysema involve long-term exposure of animals to cigarette smoke, focusing on the cell type involved in the protease/antiprotease imbalance and on extracellular matrix degradation. In emphysema, increased expression of metalloproteinases is associated with cytokines, and evidence suggests that the matrix metalloproteinase-12 (MMP-12) plays an important role. Our objective was to investigate tissue inhibitor of metalloproteinase-2 (TIMP-2), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) detection by immunohistochemical methods in mouse lung...
October 2008: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
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